Publications: Prof John Marshall
Ahmed EN, Cutmore LC, Marshall JF
(
2024
)
.
Syngeneic Mouse Models for Pre-Clinical Evaluation of CAR T Cells
.
Cancers
vol.
16
,
(
18
)
Brown NF, Murray ER, Cutmore LC, Howard P, Masterson L, Zammarchi F, Hartley JA, van Berkel PH et al.
(
2024
)
.
Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer
.
Pancreatology
vol.
24
,
(
3
)
445
-
455
.
Zheng T, O'Neill C, Marshall JF, Iskratsch T, Palma M
(
2024
)
.
Selective Placement of Functionalised DNA Origami via Thermal Scanning Probe Lithography Patterning
.
Materials Advances
Brown NF, Cutmore L, Murray E, Marshall JF
(
2023
)
.
53P Integrin-αvβ6 targeted CAR T cells in an immunocompetent orthotopic model of pancreatic cancer
.
Immuno-Oncology Technology
vol.
20
,
Marshall JF, Protopapa P, Allen N
(
2023
)
.
αv Integrin-Dependent TGFβ Activation in Cancer: A Brief Update
.
Integrins in Health and Disease
,
vol.
13
,
Springer Nature
Gibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A et al.
(
2023
)
.
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
.
npj Breast Cancer
vol.
9
,
(
1
)
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF, Jones JL
(
2022
)
.
Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
.
npj Breast Cancer
vol.
8
,
(
1
)
Meecham A, Cutmore LC, Protopapa P, Rigby LG, Marshall JF
(
2022
)
.
Ligand-bound integrin αvβ6 internalisation and trafficking
.
Frontiers in Cell and Developmental Biology
vol.
10
,
Hung K-Y, Kowalczyk R, Desai A, Brimble MA, Marshall JF, Harris PWR
(
2022
)
.
Synthesis and Systematic Study on the Effect of Different PEG Units on Stability of PEGylated, Integrin-αvβ6-Specific A20FMDV2 Analogues in Rat Serum and Human Plasma
.
Molecules
vol.
27
,
(
14
)
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
(
2022
)
.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
.
Cell Reports
vol.
38
,
(
4
)
Kashani R, Khan N, Foster J, Young J, Marshall J, Sosabowski JK
(
2022
)
.
Optimisation of αvβ6-specific peptides for use in targeted radionuclide therapy
.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
.
vol.
49
,
S142
-
S142
.
Murray ER, Brown NF, Howard P, Masterson L, Zammarchi F, van Berkel PH, Marshall JF
(
2021
)
.
Abstract 958: Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin αvβ6-targeting peptide-drug conjugate
.
Cancer Research
vol.
81
,
(
13_Supplement
)
958
-
958
.
Cutmore LC, Marshall JF
(
2021
)
.
Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer
.
Cancers
vol.
13
,
(
8
)
Raj D, Nikolaidi M, Garces I, Lorizio D, Castro NM, Caiafa SG, Moore K, Brown NF et al.
(
2021
)
.
CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma
.
Clinical Cancer Research
vol.
27
,
(
5
)
1538
-
1552
.
Meecham A, Marshall J
(
2021
)
.
Harnessing the power of foot-and-mouth-disease virus for targeting integrin alpha-v beta-6 for the therapy of cancer
.
Expert Opinion on Drug Discovery
vol.
16
,
(
7
)
737
-
744
.
Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A et al.
(
2021
)
.
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
.
Nature Genetics
vol.
53
,
(
1
)
16
-
26
.
Murray ER, Brown NF, Howard P, Masterson L, Zammarchi F, van Berkel PH, Marshall JF
(
2021
)
.
Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin avβ6-targeting peptide-drug conjugate
.
CANCER RESEARCH
.
vol.
81
,
Ohaida K, Allen M, Goom J, Marshall J, Jones L
(
2021
)
.
Relationship between altered myoepithelial phenotype and the inflammatory cell infiltrate in progression of DCIS
.
BREAST
.
vol.
56
,
S34
-
S34
.
Cutmore L, Brown N, Marshall JF
(
2020
)
.
Human and Murine CAR T cells for targeting integrin Alpha V Beta 6 in Pancreatic Ductal Adenocarcinoma
.
Pancreatology
vol.
20
,
(
8
)
Raj D, Marshall J, Young TS, Aicher A, Heeschen C
(
2020
)
.
Switchable CAR-T cells mediate long-term remission of PDAC
.
Pancreatology
vol.
20
,
(
8
)
Meecham A, Marshall JF
(
2020
)
.
The ITGB6 gene: its role in experimental and clinical biology
.
Gene
vol.
763S
,
Cutmore L, Cornish D, Brown N, Nikolaidi M, Raj D, Heeschen C, Marshall J
(
2020
)
.
VAR2CSA-based CAR-T cells for the treatment of pancreatic ductal adenocarcinoma
.
Pancreatology
vol.
20
,
(
8
)
e6
-
e7
.
Brown N, Nikolaidi M, Cutmore L, Cornish D, Raj D, Heeschen C, Marshall J
(
2020
)
.
αvβ6 targeted CAR-T cells in immunocompetent orthotopic murine PDAC
.
Pancreatology
vol.
20
,
(
8
)
Bardhan A, Bruckner-Tuderman L, Chapple ILC, Fine J-D, Harper N, Has C, Magin TM, Marinkovich MP et al.
(
2020
)
.
Epidermolysis bullosa
.
Nature Reviews Disease Primers
vol.
6
,
(
1
)
Dexter K, BROWN N, Foster J, Kashani R, CHUPIN J, Cleaver J, Cutmore L, Marshall J et al.
(
2020
)
.
Simultaneous dual isotope PET-SPECT/CT imaging of pancreatic cancer
.
Presented at:
EMIM 2020
,
Abstract:
java.sql.Clob
org.hibernate.engine.jdbc.WrappedClob
java.io.Serializable
,
Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V-M, Alexander S, Jones E et al.
(
2020
)
.
Loss of Laminin α3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma
.
British Journal of Dermatology
Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR et al.
(
2020
)
.
Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma
.
Pancreatology
Moore KM, Desai A, de Luxán Delgado B, Trabulo SMD, Reader C, Brown NF, Murray ER, Brentnall A et al.
(
2020
)
.
Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus
.
Theranostics
vol.
10
,
(
7
)
2930
-
2942
.
Brown NF, Marshall JF
(
2019
)
.
Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
.
Cancers
vol.
11
,
(
9
)
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al.
(
2019
)
.
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy
.
The Journal of Pathology
vol.
249
,
(
3
)
332
-
342
.
Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T et al.
(
2019
)
.
Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control
.
Faraday Discussions
Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D et al.
(
2019
)
.
A framework for the development of effective anti-metastatic agents
.
Nat Rev Clin Oncol
vol.
16
,
(
3
)
185
-
204
.
HUANG D, PATEL K, Perez-Garrido S, MARSHALL J, PALMA M
(
2019
)
.
DNA Origami Nanoarrays for Multivalent
Investigations of Cancer Cell Spreading with
Nanoscale Spatial Resolution and Single-
Molecule Control
.
ACS Nano
Thomas JR, Moore KM, Sproat C, Mo S, Wolanska KI, Maldonado H, Haider S, Newman D et al.
(
2019
)
.
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
100
,
A39
-
A39
.
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
(
2018
)
.
P1.03-19 Antibody Blockade of Integrin Alpha-V-Beta-6 (avb6) as a Novel Treatment for NSCLC
.
Journal of Thoracic Oncology
.
vol.
13
,
s518
-
s519
.
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al.
(
2018
)
.
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
.
Cell Reports
vol.
22
,
(
9
)
2469
-
2481
.
Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL, Halldén G
(
2018
)
.
The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells
.
Molecular Cancer Therapeutics
vol.
17
,
(
2
)
575
-
587
.
Marshall JF
(
2018
)
.
Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?
.
Clinical Cancer Research
vol.
24
,
(
2
)
253
-
255
.
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
(
2018
)
.
12 Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC
.
Lung Cancer
vol.
115
,
s5
-
s6
.
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
(
2018
)
.
Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC
.
LUNG CANCER
.
vol.
115
,
S5
-
S6
.
Pinnington SJL, Marshall JF, Wheeler AP
(
2018
)
.
Correlative 3D Structured Illumination Microscopy and Single-Molecule Localization Microscopy for Imaging Cancer Invasion
.
Methods Mol Biol
vol.
1764
,
253
-
265
.
Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole E
(
2018
)
.
Loss of Lamα3 drives M2 macrophage differentiation in squamous cell carcinoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
178
,
E399
-
E400
.
Man YKS, Davies JA, Coughlan L, Pantelidou C, Marshall JF, Parker AL, Hallden G
(
2017
)
.
The novel oncolytic adenoviral mutant Ad5-3 Delta-A20T retargeted to alpha v beta 6-integrins efficiently eliminates pancreatic cancer cells
.
HUMAN GENE THERAPY
.
Conference:
IAM Mexico
vol.
28
,
A27
-
A27
.
Caley M, Martins V, Moore K, Lashari M, Marshall J, O’Toole EA
(
2017
)
.
336 Tumour associated macrophage recruitment in SCC
.
Journal of Investigative Dermatology
.
vol.
137
,
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al.
(
2017
)
.
Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells
.
Molecular Therapy
vol.
25
,
(
10
)
2427
-
2427
.
Hayward M, Allen MD, Gomm JJ, Haywood L, Marshall JF, Jones LJ
(
2017
)
.
Myoepithelial Cell Phenotype in DCIS Progression: Functional Significance of Integrin alpha v beta 6 and Fibronectin
.
JOURNAL OF PATHOLOGY
.
Conference:
Belfast Pathology 2017
from:
20/06/2017
to:
23/06/2017
,
vol.
243
,
S16
-
S16
.
Raab-Westphal S, Marshall JF, Goodman SL
(
2017
)
.
Integrins as Therapeutic Targets: Successes and Cancers
.
Cancers (Basel)
vol.
9
,
(
9
)
Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez M-A, Kiely P, Moutasim KA et al.
(
2017
)
.
Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch
.
J Pathol
vol.
243
,
(
1
)
37
-
50
.
Hung K-Y, Harris PWR, Desai A, Marshall JF, Brimble MA
(
2017
)
.
Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality
.
Eur J Med Chem
vol.
136
,
154
-
164
.
Hodgins NO, Al-Jamal WT, Wang JT-W, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J et al.
(
2017
)
.
Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy
.
Journal of Controlled Release
vol.
256
,
141
-
152
.
Sarper M, Allen MD, Gomm J, Haywood L, Decock J, Thirkettle S, Ustaoglu A, Sarker S-J et al.
(
2017
)
.
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
.
Breast Cancer Research
vol.
19
,
(
1
)
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J
(
2017
)
.
Development of non-invasive imaging of integrin alpha-v-beta-6 (alpha v beta 6)-positive lung cancers in advance of testing alpha v beta 6-targeted therapies
.
Lung Cancer
.
Conference:
British Thoracic Oncology Group Conference 2017
(
Dublin, Ireland
)
from:
25/01/2017
to:
27/01/2017
,
vol.
103
,
S4
-
S4
.
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al.
(
2017
)
.
Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells
.
Molecular Therapy
vol.
25
,
(
1
)
259
-
273
.
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J
(
2017
)
.
6: Development of non-invasive imaging of integrin alpha-v-beta-6 (αvβ6)-positive lung cancers in advance of testing αvβ6-targeted therapies
.
Lung Cancer
vol.
103
,
Reader CS, Morton JP, Sansom OJ, Marshall JF
(
2016
)
.
Abstract A18: The integrin αvβ6 regulates PDAC cell growth and stromal cell behavior
.
Cancer Research
vol.
76
,
(
24_Supplement
)
a18
-
a18
.
Vallath S, Reader C, Morton J, Sansom O, Evans J, Biankin A, Barry ST, Kocher H et al.
(
2016
)
.
Abstract B53: The integrin αvβ6 is a promising therapeutic target for treating PDAC
.
Cancer Research
.
vol.
76
,
b53
-
b53
.
Hayward M, Allen MD, Dreger S, Marshall JF, Jones JL
(
2016
)
.
Investigating the Functional Significance of Aberrant alpha v beta 6 and Fibronectin Expression in Myoepithelial Cells: Role in the Progression of DCIS?
.
JOURNAL OF PATHOLOGY
.
Conference:
Nottingham Pathology 2016
from:
28/06/2016
to:
01/07/2016
,
vol.
240
,
28
-
28
.
Slack R, John A, Forty E, Mercer P, Graves R, Pun T, Vitulli G, Gower E et al.
(
2016
)
.
P112 Discovery of a Novel, High Affinity, Small Molecule αvβ6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis
.
QJM
vol.
109
,
(
suppl_1
)
s60
-
s60
.
Caley M, Martins V, Moore K, Lashari M, Kähäri V, Nissinen L, Donaldson M, Marshall J et al.
(
2016
)
.
472 Loss of Laminin α3 drives SCC invasion via ROCK signalling
.
Journal of Investigative Dermatology
.
vol.
136
,
Khan Z, Marshall JF
(
2016
)
.
The role of integrins in TGFβ activation in the tumour stroma
.
Cell and Tissue Research
vol.
365
,
(
3
)
657
-
673
.
Man YKS, Pantelidou C, Blázquez-Moreno A, Coughlan L, Marshall J, Kocher H, Halldén G
(
2016
)
.
Modifying oncolytic viral therapy for pancreatic cancer
.
Pancreatology
vol.
16
,
(
3
)
Marshall J, Vallath S, Reader C, Morton J, Sansom O, Evans TRJ, Biankin A, Kocher HM
(
2016
)
.
The integrin αvβ6 is a promising therapeutic target for treating PDAC
.
Pancreatology
vol.
16
,
(
3
)
Allen N, Allen M, Gomm J, Hayward L, Ahmed K, Marshall J, Jones L
(
2016
)
.
The role of Galectin-7 in normal and DCIS-associated myoepithelial cells: predicting progression of DCIS
.
European Journal of Surgical Oncology
vol.
42
,
(
5
)
Heuser S, Hufbauer M, Steiger J, Marshall J, Sterner-Kock A, Mauch C, Zigrino P, Akgül B
(
2016
)
.
The fibronectin/α3β1 integrin axis serves as molecular basis for keratinocyte invasion induced by βHPV
.
Oncogene
vol.
35
,
(
34
)
4529
-
4539
.
Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC
(
2016
)
.
Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2
.
Pharmacology
vol.
97
,
(
3-4
)
114
-
125
.
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic R, Violette S, Ghaem-Maghami S, Vallath S et al.
(
2016
)
.
Abstract B129: Chimeric antigen receptor T-cells targeting the αvβ6 integrin demonstrate potent antitumor activity in multiple solid tumors
.
Cancer Immunology Research
.
vol.
4
,
b129
-
b129
.
Pantelidou C, Man YKS, Coughlan L, Marshall J, Kocher H, Hallden G
(
2016
)
.
Oncolytic adenoviral mutants deleted in the anti-apoptotic E1B19K gene sensitize pancreatic cancer cells to drug-induced DNA damage
.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
vol.
38
,
S58
-
S58
.
Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA
(
2016
)
.
ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
174
,
E51
-
E51
.
Huang D, Keseroglu K, Garrido S, Sapelkin A, Marshall J, Palma M
(
2016
)
.
Single-molecule investigations via DNA nanostructures: A cell adhesion study
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
vol.
252
,
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al.
(
2015
)
.
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC
.
J Natl Cancer Inst
vol.
108
,
(
1
)
Reader CS, Vallath S, Morton J, Steele C, Kocher HM, Keyse SM, Sansom O, Marshall JF
(
2015
)
.
Abstract B87: Cell lines generated from PDAC transgenic mice reveal integrin αvβ6 modifies the invasive phenotype of pancreatic cancer
.
Cancer Research
.
vol.
75
,
b87
-
b87
.
Moutasim KA, Mellows T, Marshall JF, Jenei V, Thomas GJ
(
2015
)
.
Hedgehog Inhibition Results in the Upregulation of Pro-Tumourigenic αvβ6 Integrin Expression and Function in Cancer
.
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology
vol.
119
,
(
3
)
Rudran B, Marshall JF
(
2015
)
.
7: The integrin αvβ6: a new target for therapy in non-small cell lung cancer
.
Lung Cancer
.
vol.
87
,
Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al.
(
2015
)
.
Skin type VII collagen acts as a tumour suppressor by regulating TGFβ and angiogenesis
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
135
,
S28
-
S28
.
Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E
(
2015
)
.
Squamous Cell Carcinoma progression and Laminin 332
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
135
,
S23
-
S23
.
Paillas S, Desai A, Quetier I, Marshall J, Pouget J, Sosabowski J
(
2015
)
.
Targeted Radionuclide Therapy using high-LET particle emitter-labeled vectors against alpha-v-beta6-expressing cancers
.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
.
vol.
42
,
S201
-
S201
.
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al.
(
2014
)
.
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma
.
Genome Medicine
vol.
6
,
(
12
)
Allen MD, Marshall JF, Jones JL
(
2014
)
.
αvβ6 Expression in myoepithelial cells: a novel marker for predicting DCIS progression with therapeutic potential
.
Cancer Res
vol.
74
,
(
21
)
5942
-
5947
.
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.
(
2014
)
.
Therapeutic targeting of integrin αvβ6 in breast cancer
.
J Natl Cancer Inst
vol.
106
,
(
8
)
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.
(
2014
)
.
Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer
.
Molecular Cancer Research
vol.
11
,
(
10_Supplement
)
b046
-
b046
.
Elosegui-Artola A, Bazellières E, Allen MD, Andreu I, Oria R, Sunyer R, Gomm JJ, Marshall JF et al.
(
2014
)
.
Rigidity sensing and adaptation through regulation of integrin types
.
Nat Mater
vol.
13
,
(
6
)
631
-
637
.
Vallath S, Gadaletta E, Chelala C, Scarpa A, Hart IR, Kocher HM, Marshall JF
(
2012
)
.
Abstract B42: Toward targeting integrin αvβ6 for the therapy of pancreatic cancer
.
Conference:
Therapyb42
-
b42
.
Vallath S, Scarpa A, Weinreb P, Violette S, Steele C, Morton J, Sansom O, Davies J et al.
(
2014
)
.
The integrin αvβ6 is a promising target for the therapy of PDAC: toward phase I trials
.
Pancreatology
vol.
14
,
(
2
)
Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA et al.
(
2014
)
.
Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence
.
Clin Cancer Res
vol.
20
,
(
2
)
344
-
357
.
Muhammad H, Taher T, Mullen L, Pastan I, Marshall J, Chernajovsky Y, Gould D, Mageed R
(
2014
)
.
Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer
.
HUMAN GENE THERAPY
.
vol.
25
,
A5
-
A5
.
Caley M, Martins V, Moore K, Marshall J, O'toole E
(
2014
)
.
Diverse roles for laminin 332 subunits in squamous cell carcinoma
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
134
,
S19
-
S19
.
Caley M, Martins V, Moore K, Marshall J, O'Toole E
(
2014
)
.
Diverse roles for laminin-332 subunits in squamous cell carcinoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
170
,
E26
-
E26
.
Moutasim KA, Mellows T, Mellone M, Lopez M-A, Tod J, Kiely PC, Sapienza K, Greco A et al.
(
2014
)
.
Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function
.
JOURNAL OF PATHOLOGY
vol.
233
,
(
2
)
196
-
208
.
Moore K, Thomas G, Duffy S, Warwick J, Gabe R, Chou P, Ellis I, Green A et al.
(
2013
)
.
Abstract P4-15-01: Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy
.
Cancer Research
vol.
73
,
(
24_Supplement
)
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al.
(
2013
)
.
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
.
Gastroenterology
vol.
145
,
(
5
)
1121
-
1132
.
Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K et al.
(
2013
)
.
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
.
Breast Cancer Research
vol.
15
,
(
5
)
Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, Marshall J, O'Meara S et al.
(
2013
)
.
Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma
.
Nature Genetics
vol.
45
,
(
8
)
923
-
926
.
Eberlein C, Kendrew J, McDaid K, Alfred A, Kang JS, Jacobs VN, Ross SJ, Rooney C et al.
(
2013
)
.
A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers <i>in vivo</i>
.
ONCOGENE
vol.
32
,
(
37
)
4406
-
4416
.
Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA
(
2013
)
.
Diverse roles for laminin 332 subunits in squamous cell carcinoma
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
133
,
S64
-
S64
.
Ali I, Gautrot J, Caley M, Marshall JF, Wheeler A
(
2013
)
.
Formation and inhibition of invadopodia in oral squamous cell carcinoma
.
MOLECULAR BIOLOGY OF THE CELL
.
vol.
24
,
Kogelberg H, Miranda E, Burnet J, Ellison D, Tolner B, Foster J, Picón C, Thomas GJ et al.
(
2013
)
.
Generation and characterization of a diabody targeting the αvβ6 integrin
.
PLoS One
vol.
8
,
(
9
)
Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al.
(
2013
)
.
Loss of type VII collagen in cutaneous SCC increases angiogenesis
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
133
,
S158
-
S158
.
Sarper M, Allen MD, Decock J, Thirkettle S, Edwards DR, Marshall JF, Jones LJ
(
2013
)
.
MMP-8 Loss Contributes to Altered Myoepithelial Cell Function in DCIS
.
JOURNAL OF PATHOLOGY
.
vol.
229
,
S11
-
S11
.
John AE, Luckett JC, Tatler AL, Awais RO, Habgood A, Ludbrook S, Blanchard A, Perkins AC et al.
(
2013
)
.
Pre-Clinical Imaging Of The αvβ6 Integrin For Molecular Stratification Of Idiopathic Pulmonary Fibrosis
.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
.
vol.
187
,
John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, Ludbrook S, Blanchard AD et al.
(
2013
)
.
Preclinical SPECT/CT Imaging of αvβ6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis
.
JOURNAL OF NUCLEAR MEDICINE
vol.
54
,
(
12
)
2146
-
2152
.
Elosegui-Artola A, Bazellieres E, Allen MD, Andreu I, Marshall JF, Jones JL, Trepat X, Roca-Cusachs P
(
2013
)
.
Rigidity sensing and adaptation through regulation of integrin populations
.
MOLECULAR BIOLOGY OF THE CELL
vol.
24
,
Voet T, Kumar P, Van Loo P, Cooke SL, Marshall J, Lin ML, Esteki MZ, Van Der Aa N et al.
(
2013
)
.
Single-cell paired-end genome sequencing reveals structural variation per cell cycle
.
Nucleic Acids Research
vol.
41
,
Article
12
,
6119
-
6138
.
Man YKS, DiCara D, Chan N, Vessillier S, Mather SJ, Rowe ML, Howard MJ, Marshall JF et al.
(
2013
)
.
Structural guided scaffold phage display libraries as a source of bio-therapeutics
.
PLoS One
vol.
8
,
(
8
)
Ahmed KO, Allen M, Gomm J, Marshall J, Jones JL
(
2012
)
.
16P Myoepithelial Control of the Inflammatory Microenvironment Promotes Transition of Dcis to Invasive Disease
.
Annals of Oncology
vol.
23
,
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF, Crnogorac-Jurcevic T
(
2012
)
.
S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells
.
Am J Pathol
vol.
180
,
(
4
)
1485
-
1494
.
Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ, Fu B, Hims M, Ding Z et al.
(
2012
)
.
Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer
.
Cell
vol.
148
,
(
4
)
780
-
791
.
Sarper M, Allen M, Decock J, Marshall JF, Edwards DR, Jones JL
(
2012
)
.
Loss of MMP-8 Expression Contributes to Altered Myoepithelial Cell Function in DCIS
.
JOURNAL OF PATHOLOGY
.
vol.
226
,
S13
-
S13
.
Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA
(
2012
)
.
Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
132
,
S45
-
S45
.
Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E
(
2012
)
.
Loss of type VII collagen in squamous cell carcinoma increases angiogenesis <i>in vitro</i> and <i>in vivo</i>
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
166
,
e25
-
e26
.
Ahmed KO, Allen M, Gomm J, Marshall J, Jones JL
(
2012
)
.
MYOEPITHELIAL CONTROL OF THE INFLAMMATORY MICROENVIRONMENT PROMOTES TRANSITION OF DCIS TO INVASIVE DISEASE
.
ANNALS OF ONCOLOGY
.
vol.
23
,
19
-
19
.
Wagstaff JL, Rowe ML, Hsieh S-J, DiCara D, Marshall JF, Williamson RA, Howard MJ
(
2012
)
.
NMR relaxation and structural elucidation of peptides in the presence and absence of trifluoroethanol illuminates the critical molecular nature of integrin αvβ6 ligand specificity
.
RSC ADVANCES
vol.
2
,
(
29
)
11019
-
11028
.
Awais RO, Mather SJ, John AE, Luckett JCA, Habgood A, Jenkins GR, Marshall JF, Perkins AC
(
2012
)
.
NanoSPECT/CT imaging of pulmonary αvβ6 with [In-111]A20FMDV2 as a surrogate marker for monitoring lung fibrosis
.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
.
vol.
39
,
S215
-
S215
.
John AE, Luckett J, Awas R, Habgood A, Ludbrook S, Blanchard A, Perkins A, Jenkins RG et al.
(
2012
)
.
TARGETED IN VIVO IMAGING OF THE αVβ6 INTEGRIN IN MICE WITH BLEOMYCIN-INDUCED LUNG FIBROSIS
.
THORAX
.
vol.
67
,
A33
-
A33
.
Dreger SA, Payne SJ, Dawoud M, Robinson SD, Marshall JF, Hodivala-Dilke KM, Allen MD, Jones JL
(
2012
)
.
Up-regulation of αvβ6 integrin and fibronectin EDA in myoepithelial cells contribute to the angiogenic switch in pre-invasive breast cancer
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
93
,
A24
-
A24
.
Moore K, Hart I, Jones L, Marshall J
(
2011
)
.
P2-01-05: Integrin avb6 Mediates HER2−Driven Invasion in Breast Cancer
.
Cancer Research
vol.
71
,
(
24_Supplement
)
Roy S, Bingle L, Marshall JF, Bass R, Ellis V, Speight PM, Whawell SA
(
2011
)
.
The role of α9β1 integrin in modulating epithelial cell behaviour
.
Journal of Oral Pathology and Medicine
vol.
40
,
(
10
)
755
-
761
.
Martins VL, Moore K, Chen M, Marshall J, O'Toole EA
(
2011
)
.
Loss of type VII collagen in SCC leads to increased invasion and TGF-beta signalling in vivo
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
164
,
910
-
910
.
Martins V, Moore K, Chen M, Marshall J, O'Toole EA
(
2011
)
.
Loss of type VII collagen in squamous cell carcinoma leads to increased invasion and TGF-beta signalling in vivo
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
131
,
S33
-
S33
.
Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF
(
2011
)
.
Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion
.
Oncogene
vol.
30
,
(
12
)
1422
-
1435
.
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al.
(
2011
)
.
Stromal features are predictive of disease mortality in oral cancer patients
.
J Pathol
vol.
223
,
(
4
)
470
-
481
.
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al.
(
2011
)
.
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis
.
J Pathol
vol.
223
,
(
3
)
366
-
377
.
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D et al.
(
2011
)
.
Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma
.
nature
vol.
186
,
Article
3
,
1150
-
1150
.
Marshall J
(
2011
)
.
Transwell(®) invasion assays
.
Methods Mol Biol
vol.
769
,
97
-
110
.
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al.
(
2010
)
.
Stromal features are predictive of disease mortality in oral cancer patients
.
J Pathol
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al.
(
2010
)
.
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis
.
J Pathol
Sapienza K, Sale S, Hague A, Hart IR, Marshall JF, Thomas GJ
(
2010
)
.
EP4-mediated prostanoid signalling promotes oral cancer progression
.
BMC Proceedings
vol.
4
,
(
Suppl 2
)
Moutasim KA, Jenei V, Sapienza K, Marsh D, Marshall J, Fortune F, Tilakaratne WM, Hart IR et al.
(
2010
)
.
Alkaloid-dependent upregulation of AlphavBeta6 integrin promotes oral submucous fibrosis
.
ORAL DIS
vol.
16
,
(
6
)
528
-
528
.
Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF
(
2010
)
.
High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6
.
J Pathol
vol.
222
,
(
1
)
52
-
63
.
Froeling FEM, Marshall JF, Kocher HM
(
2010
)
.
Pancreatic cancer organotypic cultures
.
J Biotechnol
vol.
148
,
(
1
)
16
-
23
.
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M
(
2010
)
.
Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis
.
J Leukoc Biol
vol.
87
,
(
5
)
877
-
884
.
Alexopoulou AN, Leao M, Caballero OL, Da Silva L, Reid L, Lakhani SR, Simpson AJ, Marshall JF et al.
(
2010
)
.
Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
.
Breast Cancer Res
vol.
12
,
(
4
)
Wagstaff JL, Vallath S, Marshall JF, Williamson RA, Howard MJ
(
2010
)
.
Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin alpha v beta 6 protein-peptide interactions
.
CHEM COMMUN
vol.
46
,
(
40
)
7533
-
7535
.
Jones J, Allen M, Thomas G, Dawoud M, Vallath S, Payne S, Edwards D, Pennington C et al.
(
2009
)
.
DCIS-Associated Myoepithelial Cells Expressing the αvβ6 Integrin Modify Tumour Cell Behaviour: A Predictor of Invasive Progression?
.
Cancer Research
vol.
69
,
(
24_Supplement
)
4159
-
4159
.
Payne SJL, Allen M, Dreger S, Marshall J, Hodiavala-Dilke K, Hart I, Jones L
(
2009
)
.
Myoepithelial Cells in DCIS Exhibit an Altered Phenotype and Promote Angiogenesis
.
CANCER RESEARCH
.
vol.
69
,
642S
-
643S
.
Payne S, Allen M, Dreger S, Marshall J, Hodiavala-Dilke K, Hart I, Jones L
(
2009
)
.
Myoepithelial Cells in DCIS Exhibit an Altered Phenotype and Promote Angiogenesis
.
Cancer Research
vol.
69
,
(
24_Supplement
)
2155
-
2155
.
Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF et al.
(
2009
)
.
Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
.
J Biol Chem
vol.
284
,
(
49
)
33966
-
33981
.
Gagnon MKJ, Hausner SH, Marik J, Abbey CK, Marshall JF, Sutcliffe JL
(
2009
)
.
High-throughput in vivo screening of targeted molecular imaging agents
.
P NATL ACAD SCI USA
vol.
106
,
(
42
)
17904
-
17909
.
Hausner SH, Abbey CK, Bold RJ, Gagnon MK, Marik J, Marshall JF, Stanecki CE, Sutcliffe JL
(
2009
)
.
Targeted In vivo Imaging of Integrin alpha(v)beta(6) with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model
.
CANCER RES
vol.
69
,
(
14
)
5843
-
5850
.
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR et al.
(
2009
)
.
In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery
.
J Virol
vol.
83
,
(
13
)
6416
-
6428
.
Coughlan L, Vallath S, Saha A, McNeish IA, Vassaux G, Marshall JF, Hart IR, Thomas GJ
(
2009
)
.
An Ad5 Vector Retargeted to alpha v beta 6 Displays Improved Tumour Transduction Combined with Reduced Liver Uptake Following Systemic Delivery
.
MOLECULAR THERAPY
.
vol.
17
,
S323
-
S323
.
Sampaio ALF, Leoni G, Marshall JF, Perretti M
(
2009
)
.
A role for alpha 5 beta 1 integrin in leukocyte accumulation in acute peritonitis
.
EUR J CLIN INVEST
.
vol.
39
,
22
-
23
.
Hausner SH, Kukis DL, Gagnon MKJ, Stanecki CE, Ferdani R, Marshall JF, Anderson CJ, Sutcliffe JL
(
2009
)
.
Evaluation of [Cu-64]Cu-DOTA and [Cu-64]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an alpha(v)beta(6)-Specific Peptide
.
MOL IMAGING
vol.
8
,
(
2
)
111
-
121
.
Kogelberg H, Tolner B, Thomas GJ, Di Cara D, Minogue S, Ramesh B, Sodha S, Marsh D et al.
(
2008
)
.
Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus
.
J Mol Biol
vol.
382
,
(
2
)
385
-
401
.
Coughlan L, McNeish I, Vassaux G, Marshall J, Hart IR, Thomas G
(
2008
)
.
Transductional retargeting of adenovirus-5 to alphavbeta6 integrin
.
HUMAN GENE THERAPY
.
vol.
19
,
1102
-
1102
.
Lees DM, Hart IR, Marshall JF
(
2008
)
.
Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues
.
J Mol Biol
vol.
379
,
(
4
)
645
-
655
.
Roy S, Marshall JF, Speight PM, Whawell SA
(
2008
)
.
Role of alpha 9 beta 1 integrin in the regulation of epithelial cell behaviour
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
89
,
A8
-
A9
.
Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ
(
2008
)
.
alpha v beta 6 integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation
.
CANCER RES
vol.
68
,
(
9
)
3295
-
3303
.
Dicara D, Burman A, Clark S, Berryman S, Howard MJ, Hart IR, Marshall JF, Jackson T
(
2008
)
.
Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness
.
J Virol
vol.
82
,
(
3
)
1537
-
1546
.
Hausner SH, Marik J, DiCara D, Abbey CK, Gagnon MKJ, Bold R, Marshall JF, Sutcliffe JL
(
2008
)
.
CMR 2007: 4.04: Improved molecular imaging probe for in vivo detection of the integrin αvβ6
.
Contrast Media & Molecular Imaging
vol.
2
,
(
6
)
284
-
284
.
MARSHALL JF, CHAN W, HART IR
(
2008
)
.
EFFECT OF PHOTODYNAMIC THERAPY ON ANTITUMOR IMMUNE DEFENSES: COMPARISON OF THE PHOTOSENSITIZERS HEMATOPORPHYRIN DERIVATIVE AND CHLORO‐ALUMINUM SULFONATED PHTHALOCYANINE
.
Photochemistry and Photobiology
vol.
49
,
(
5
)
627
-
632
.
Chan W, Marshall JF, Hart IR
(
2008
)
.
PHOTODYNAMIC THERAPY OF A MURINE TUMOR FOLLOWING SENSITISATION WITH CHLORO ALUMINUM SULFONATED PHTHALOCYANINE
.
Photochemistry and Photobiology
vol.
46
,
(
5
)
867
-
871
.
Chan W, Marshall JF, Svensen R, Phillips D, Hart IR
(
2008
)
.
PHOTOSENSITISING ACTIVITY OF PHTHALOCYANINE DYES SCREENED AGAINST TISSUE CULTURE CELLS
.
Photochemistry and Photobiology
vol.
45
,
(
6
)
757
-
761
.
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL
(
2008
)
.
De novo expression of alpha(v)beta(6) integrin by myoepithelial cells in ductal carcinoma in situ may be an important marker of disease progression
.
BREAST CANCER RESEARCH
.
vol.
10
,
S16
-
S16
.
Jones JL, Thomas GJ, Duffy SW, Gabe R, Ellis I, Green A, Saha A, Mulligan KT et al.
(
2007
)
.
Expression of alphavbeta6 supersedes Her2 and triple-negative/basal classification of breast cancer and defines novel subgroups with poor survival: implications for breast cancer classification and treatment
.
BREAST CANCER RESEARCH AND TREATMENT
.
vol.
106
,
S11
-
S11
.
Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E
(
2007
)
.
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
.
Nat Cell Biol
vol.
9
,
(
12
)
1392
-
1400
.
Ramsay AG, Marshall JF, Hart IR
(
2007
)
.
Integrin trafficking and its role in cancer metastasis
.
Cancer Metastasis Rev
vol.
26
,
(
3-4
)
567
-
578
.
Clark SE, Marshall JE, Hart IR, Carpenter R, Jones JL
(
2007
)
.
Molecular profiling of DCIS: identification of distinct subgroups of potential prognostic importance
.
BREAST CANCER RESEARCH AND TREATMENT
.
vol.
106
,
S221
-
S221
.
Hausner SH, DiCara D, Marik J, Marshall JF, Sutcliffe JL
(
2007
)
.
Use of a peptide derived from foot-and-mouth disease virus for the Noninvasive Imaging of human cancer: Generation and evaluation of 4-[F-18]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alpha(v)beta(6) expression with positron emission tomography
.
CANCER RES
vol.
67
,
(
16
)
7833
-
7840
.
Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, Weinreb P, Hart IR et al.
(
2007
)
.
HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6
.
Cancer Res
vol.
67
,
(
11
)
5275
-
5284
.
DiCara D, Rapisarda C, Sutcliffe JL, Violette SM, Weinreb PH, Hart IR, Howard MJ, Marshall JF
(
2007
)
.
Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands
.
J Biol Chem
vol.
282
,
(
13
)
9657
-
9665
.
Nystrom ML, McCulloch D, Weinreb PH, Violette SM, Speight PM, Marshall JF, Hart IR, Thomas GJ
(
2006
)
.
Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion
.
Cancer Res
vol.
66
,
(
22
)
10833
-
10842
.
Hart I, Dicara D, Marshall JF
(
2006
)
.
Targeting the invasion-association integrin alphavbeta6 as an anti-carcinoma strategy
.
EJC SUPPL
vol.
4
,
(
12
)
82
-
82
.
Marshall JF, Nesbitt SA, Helfrich MH, Horton MA, Polakova K, Hart IR
(
2006
)
.
Integrin expression in human melanoma cell lines: Heterogeneity of vitronectin receptor composition and function
.
International Journal of Cancer
vol.
49
,
(
6
)
924
-
931
.
Thomas GJ, Nyström ML, Marshall JF
(
2006
)
.
Alphavbeta6 integrin in wound healing and cancer of the oral cavity
.
J Oral Pathol Med
vol.
35
,
(
1
)
1
-
10
.
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL
(
2006
)
.
Functional analysis of normal and DCIS modified breast myoepithelial cells
.
BREAST CANCER RESEARCH
.
vol.
8
,
S9
-
S9
.
Salama I, Mihaimeed F, Marshall J, Jazayeri M, Thomas G, Duffy S, Jones LJ
(
2006
)
.
S100A7 and the basal phenotype in breast cancer
.
BREAST CANCER RESEARCH AND TREATMENT
.
vol.
100
,
S159
-
S159
.
Hooper S, Marshall JF, Sahai E
(
2006
)
.
Tumor cell migration in three dimensions
.
Methods Enzymol
vol.
406
,
625
-
643
.
Ylipalosaari M, Thomas GJ, Nystrom M, Salhimi S, Marshall JF, Huotari V, Tervahartiala T, Sorsa T et al.
(
2005
)
.
alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells
.
EXP CELL RES
vol.
309
,
(
2
)
273
-
283
.
Vyas J, Ahmed W, Jayazeri M, Marshall JF, Proby CM, Storey A, O'Toole EA
(
2005
)
.
Mechanisms of migration and invasion of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
152
,
843
-
843
.
Vyas JJ, Ahmed W, Jayazeri M, Baksh N, Marshall JF, Proby CM, Storey A, O'Toole EA
(
2005
)
.
Migration and invasion mechanisms in an in vitro model of squamous cell carcinogenesis
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
124
,
A22
-
A22
.
Nyström ML, Thomas GJ, Stone M, Mackenzie IC, Hart IR, Marshall JF
(
2005
)
.
Development of a quantitative method to analyse tumour cell invasion in organotypic culture
.
J Pathol
vol.
205
,
(
4
)
468
-
475
.
Scott KA, Arnott CH, Robinson SC, Moore RJ, Thompson RG, Marshall JF, Balkwill FR
(
2004
)
.
TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration?
.
Oncogene
vol.
23
,
(
41
)
6954
-
6966
.
Nystrom M, Stone M, Thomas GJ, Mackenzie I, Hart IR, Marshall JF
(
2004
)
.
A quantitative method for measuring three-dimensional invasion in vitro using organotypic cultures
.
BRITISH JOURNAL OF CANCER
.
vol.
91
,
S58
-
S58
.
Lygoe KA, Norman JT, Marshall JF, Lewis MP
(
2004
)
.
alpha v integrins play an important role in myofibroblast differentiation
.
WOUND REPAIR REGEN
vol.
12
,
(
4
)
461
-
470
.
Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF
(
2004
)
.
The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9
.
J Biol Chem
vol.
279
,
(
25
)
26533
-
26539
.
Huntley SP, Davies M, Matthews JB, Thomas G, Marshall J, Robinson CM, Eveson JW, Paterson IC et al.
(
2004
)
.
Attenuated type II TGF-B receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination
.
INT J CANCER
vol.
110
,
(
2
)
170
-
176
.
HART IR, Joshi D, Marshall JF, Russel A, Thomas GJ, Morgan MR
(
2004
)
.
The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote MMP-2 or MMP-9-mediated tumour cell invasion
.
J. Biol. Chem
vol.
279
,
26533
-
26539
.
Dalvi N, Thomas GJ, Marshall JF, Morgan M, Bass R, Ellis V, Speight PM, Whawell SA
(
2004
)
.
Modulation of the urokinase-type plasminogen activator receptor by the beta 6 integrin subunit
.
BIOCHEM BIOPH RES CO
vol.
317
,
(
1
)
92
-
99
.
Zhu G, Gilchrist R, Borley N, Chng HW, Morgan M, Marshall JF, Camplejohn RS, Muir GH et al.
(
2004
)
.
Reduction of TSG101 protein has a negative impact on tumor cell growth
.
INT J CANCER
vol.
109
,
(
4
)
541
-
547
.
Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ
(
2004
)
.
Tumour-derived TGF-beta 1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
.
BRIT J CANCER
vol.
90
,
(
4
)
822
-
832
.
Bukhary SM, Assmann V, Marshall JF, Speight PM, Thomas GJ
(
2003
)
.
Restoration of e-cadherin function alters morphology of oral squamous carcinoma cells
.
JOURNAL OF DENTAL RESEARCH
.
vol.
82
,
485
-
485
.
Thomas GJ, Hart IR, Marshall JF, Speight PM
(
2003
)
.
av beta 6 integrin interaction with the tgf-beta 1 latency-associated peptide (lap)
.
JOURNAL OF DENTAL RESEARCH
.
vol.
82
,
485
-
485
.
Morgan MR, Thomas GJ, Marshall JF
(
2003
)
.
b6-integrin cytoplasmic tail: novel intracellular target for inhibiting oral scc invasion
.
JOURNAL OF DENTAL RESEARCH
.
vol.
82
,
472
-
472
.
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RAJ
(
2003
)
.
Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes
.
J CELL SCI
vol.
116
,
(
20
)
4239
-
4248
.
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert-Heavens D, Marshall J, Fried M, Peters G
(
2003
)
.
Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes
.
Cancer Cell
vol.
4
,
(
4
)
301
-
310
.
South AP, Wan H, Stone MG, Dopping-Hepenstal PJC, Purkis PE, Marshall JF, Leigh IM, Eady RAJ et al.
(
2003
)
.
Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability
.
J CELL SCI
vol.
116
,
(
16
)
3303
-
3314
.
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al.
(
2003
)
.
Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer
.
Oncogene
vol.
22
,
(
24
)
3742
-
3748
.
VAN TRAPPEN P
(
2003
)
.
Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer
.
Oncogene
vol.
22
,
3742
-
3748
.
Morgan MR, Thomas GJ, Marshall JF
(
2003
)
.
beta 6-integrin cytoplasmic tail: Novel intracellular target for inhibiting oral SCC invasion
.
J DENT RES
vol.
82
,
B327
-
B327
.
Nystrom M, Thomas G, MacKenzie I, Hart I, Marshall J
(
2003
)
.
An in vitro 3D-Model of Invasive Squamous Cell Carcinoma (SCC) Recapitulates in vivo Pathology
.
Clinical Science
vol.
104
,
(
s49
)
28p
-
29p
.
Hampton R, Walker M, Marshall J, Juhl H
(
2002
)
.
Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells
.
ONCOGENE
vol.
21
,
(
51
)
7817
-
7823
.
Thomas GJ, Hart IR, Speight PM, Marshall JF
(
2002
)
.
Binding of TGF-beta 1 latency-associated peptide (LAP) to alpha v beta 6 integrin modulates behaviour of squamous carcinoma cells
.
BRIT J CANCER
vol.
87
,
(
8
)
859
-
867
.
Sutcliffe-Goulden JL, O'Doherty MJ, Marsden PK, Hart IR, Marshall JF, Bansal SS
(
2002
)
.
Rapid solid phase synthesis and biodistribution of F-18-labelled linear peptides
.
EUR J NUCL MED MOL I
vol.
29
,
(
6
)
754
-
759
.
Morgan MR, Thomas GJ, Russell A, Speight PM, Hart IR, Marshall JF
(
2002
)
.
The ss 6 integrin subunit C-terminal 11 amino acids are sufficient to promote invasion by squamous cell carcinoma (SCC) cells
.
BRIT J CANCER
vol.
86
,
S120
-
S120
.
Sutcliffe-Goulden JL, Marshall JF, O'Doherty MJ, Bansal S
(
2002
)
.
Solid phase synthesis of F-18-labelled cyclic peptides
.
J NUCL MED
vol.
43
,
(
5
)
365P
-
365P
.
Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, Bugat R, Burger U et al.
(
2002
)
.
First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
.
ANN ONCOL
vol.
13
,
(
4
)
566
-
575
.
Thomas GJ, Lewis MP, Marshall JF, Speight PM
(
2001
)
.
O-029. αvβ6 integrin promotes invasion of squamous carcinoma cells through upregulation of MMP-9
.
Oral Oncology
vol.
37
,
(
SUPPL. 1
)
Davison E, Kirby I, Whitehouse J, Hart I, Marshall JF, Santis G
(
2001
)
.
Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad(5) fibre binding is mediated by alpha(v)beta(1) integrin and can be modulated by changes in beta(1) integrin function
.
J GENE MED
vol.
3
,
(
6
)
550
-
559
.
Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF
(
2001
)
.
Expression of the alpha v beta 6 integrin promotes migration and invasion in squamous carcinoma cells
.
J INVEST DERMATOL
vol.
117
,
(
1
)
67
-
73
.
Gilchrist R, Stafford H, Duddy PM, Marshall JF, Camplejohn RS, Hart IR
(
2001
)
.
Mechanisms of adhesion-dependence in mouse melanocyte-derived cell lines
.
BRIT J CANCER
vol.
85
,
82
-
82
.
Morgan MR, Thomas GJ, Speight PM, Hart IR, Marshall JF
(
2001
)
.
The terminal 11a.a. cytoplasmic tail of the beta 6 integrin subunit is essential for the promotion of alpha V beta 6-dependent invasion
.
BRIT J CANCER
vol.
85
,
22
-
22
.
Thomas GJ, Lewis MP, Hart IR, Marshall JF, Speight PM
(
2001
)
.
alpha V beta 6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9
.
INT J CANCER
vol.
92
,
(
5
)
641
-
650
.
Thomas GJ, Poomsawat S, Lewis MP, Hart IR, Speight PM, Marshall JF
(
2001
)
.
alpha v beta 6 integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes
.
J INVEST DERMATOL
vol.
116
,
(
6
)
898
-
904
.
Thomas GJ, Poomsawat S, Lewis MP, Marshall JF, Speight PM
(
2001
)
.
alpha v beta 6-dependent upregulation of MMP-9 promotes keratinocyte migration
.
J DENT RES
vol.
80
,
(
4
)
1155
-
1155
.
Hapke S, Gawaz M, Dehne K, Kohler J, Marshall JF, Graeff H, Schmitt M, Reuning U et al.
(
2001
)
.
beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter
.
MOL CELL BIOL
vol.
21
,
(
6
)
2118
-
2132
.
Brunton VG, Fincham VJ, McLean GW, Winder SJ, Paraskeva C, Marshall JF, Frame MC
(
2001
)
.
The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERKMediated Actin Spike Formation: Deregulation in Cancer Cells
.
Neoplasia
vol.
3
,
(
3
)
215
-
226
.
Thorne RF, Marshall JF, Shafren DR, Gibson PG, Hart IR, Burns GF
(
2000
)
.
The Integrins α3β1 and α6β1 Physically and Functionally Associate with CD36 in Human Melanoma Cells REQUIREMENT FOR THE EXTRACELLULAR DOMAIN OF CD36*
.
Journal of Biological Chemistry
vol.
275
,
(
45
)
35264
-
35275
.
Sullivan RM, Stone M, Marshall JF, Uberall F, Rotenberg SA
(
2000
)
.
Photo-Induced Inactivation of Protein Kinase Cα by Dequalinium Inhibits Motility of Murine Melanoma Cells
.
Molecular Pharmacology
vol.
58
,
(
4
)
729
-
737
.
Schlippe MV, Marshall JF, Perry P, Stone M, Zhu AJ, Hart IR
(
2000
)
.
Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells
.
Journal of Cell Science
vol.
113
,
(
3
)
425
-
437
.
Mitjans F, Meyer T, Fittschen C, Goodman S, Jonczyk A, Marshall JF, Reyes G, Piulats J
(
2000
)
.
In vivo therapy of malignant melanoma by means of antagonists of αv integrins
.
International Journal of Cancer
vol.
87
,
(
5
)
716
-
723
.
Assmann V, Jenkinson D, Marshall JF, Hart IR
(
1999
)
.
The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments
.
Journal of Cell Science
vol.
112
,
(
22
)
3943
-
3954
.
Prest SJ, Rees RC, Murdoch C, Marshall JF, Cooper PA, Bibby M, Li G, Ali SA
(
1999
)
.
Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: Subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials
.
Clinical & Experimental Metastasis
vol.
17
,
(
5
)
389
-
396
.
Marshall JF, Hart IR
(
1999
)
.
The Role of Adhesion in Metastasis: Potential Mechanisms and Modulation of Integrin Activity
.
Advances in Molecular and Cell Biology
vol.
28
,
345
-
365
.
Saini A, Seller Z, Davies D, Marshall JF, Hart IR
(
1998
)
.
Activation status and function of the VLA‐4 (α4β1) integrin expressed on human melanoma cell lines
.
International Journal of Cancer
vol.
73
,
(
2
)
264
-
270
.
Vile RG, Castleden S, Marshall J, Camplejohn R, Upton C, Chong H
(
1998
)
.
Generation of an anti‐tumour immune response in a non‐immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1‐like profile of intratumoural cytokine expression
.
International Journal of Cancer
vol.
71
,
(
2
)
267
-
274
.
Ahmad A, Marshall JF, Basset P, Anglard P, Hart IR
(
1998
)
.
Modulation of human stromelysin 3 promoter activity and gene expression by human breast cancer cells
.
International Journal of Cancer
vol.
73
,
(
2
)
290
-
296
.
Geng L, Ali SA, Marshall JF, Mackay CL, Hart IR, Delcommence M, Streuli CH, Rees RC
(
1998
)
.
Fibronectin is chemotactic for CT 26 colon carcinoma cells: sub-lines selected for increased chemotaxis to fibronectin display decreased tumorigenicity and lung colonization
.
Clinical & Experimental Metastasis
vol.
16
,
(
8
)
683
-
691
.
Assmann V, Marshall JF, Fieber C, Hofmann M, Hart IR
(
1998
)
.
The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells
.
Journal of Cell Science
vol.
111
,
(
12
)
1685
-
1694
.
Hasan N, Adams G, Joiner M, Marshall J, Hart I
(
1998
)
.
Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability
.
British Journal of Cancer
vol.
77
,
(
11
)
1799
-
1805
.
Marshall J, Rutherford D, Happerfield L, Hanby A, McCartney A, Newton-Bishop J, Hart I
(
1998
)
.
Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas
.
British Journal of Cancer
vol.
77
,
(
4
)
522
-
529
.
Meyer T, Marshall J, Hart I
(
1998
)
.
Expression of αv integrins and vitronectin receptor identity in breast cancer cells
.
British Journal of Cancer
vol.
77
,
(
4
)
530
-
536
.
Davison E, Diaz RM, Hart IR, Santis G, Marshall JF
(
1997
)
.
Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16
.
Journal of Virology
vol.
71
,
(
8
)
6204
-
6207
.
Francia G, Mitchell SD, Moss SE, Hanby AM, Marshall JF, Hart IR
(
1996
)
.
Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression
.
Cancer Research
vol.
56
,
(
17
)
3855
-
3858
.
Marshall JF, Hart IR
(
1996
)
.
The role of αv-integrins in tumour progression and metastasis
.
Seminars in Cancer Biology
vol.
7
,
(
3
)
129
-
138
.
Marshall JF, Rutherford DC, McCartney ACE, Mitjans F, Goodman SL, Hart IR
(
1995
)
.
αvβ1 is a receptor for vitronectin and fibrinogen, and acts with α5β1 to mediate spreading on fibronectin
.
Journal of Cell Science
vol.
108
,
(
3
)
1227
-
1238
.
van Bruggen N, Chan W-S, Syha J, Marshall JF, Proctor E, Williams SR, Gadian DG, Hart IR
(
1992
)
.
Cell and tissue responses of a murine tumour to phthalocyanine-mediated photodynamic therapy
.
European Journal of Cancer
vol.
28
,
(
1
)
42
-
46
.
Burrows FJ, Haskard DO, Hart IR, Marshall JF, Selkirk S, Poole S, Thorpe PE
(
1991
)
.
Influence of tumor-derived interleukin 1 on melanoma-endothelial cell interactions in vitro
.
Cancer Research
vol.
51
,
(
18
)
4768
-
4775
.
Hart IR, Birch M, Marshall JF
(
1991
)
.
Cell adhesion receptor expression during melanoma progression and metastasis
.
Cancer and Metastasis Reviews
vol.
10
,
(
2
)
115
-
128
.
Chan WS, Marshall JF, Svensen R, Bedwell J, Hart IR
(
1990
)
.
Effect of sulfonation on the cell and tissue distribution of the photosensitizer aluminum phthalocyanine
.
Cancer Research
vol.
50
,
(
15
)
4533
-
4538
.
Chan W-S, Marshall JF, Hart IR
(
1989
)
.
Effect of tumour location on selective uptake and retention of phthalocyanines
.
Cancer Letters
vol.
44
,
(
1
)
73
-
77
.
Chan WS, Marshall JF, Lam GY, Hart IR
(
1988
)
.
Tissue uptake, distribution, and potency of the photoactivatable dye chloroaluminum sulfonated phthalocyanine in mice bearing transplantable tumors
.
Cancer Research
vol.
48
,
(
11
)
3040
-
3044
.
Hodges GM, Carr KE, Hume SP, Marigold JC, Southgate J, Marshall JF
(
1985
)
.
Changes in surface structure and concanavalin A-binding capacity of urothelium in the mouse bladder after whole-body neutron irradiation
.
Scanning Microscopy
(
Pt 4
)
1603
-
1614
.