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Publications:  Miss Lucy Norling

Norling LV, Perretti M(2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of the National Academy of Sciences of the United States of America vol. 117, (17) 9148-9150.
10.1073/pnas.2004241117
Norling L, Cooper D, Law H, Wright R, Iqbal A(2020). A pro-resolving role for Galectin-1 in acute inflammation. Frontiers in Pharmacology vol. 11, (274)
10.3389/fphar.2020.00274
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64197
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C et al.(2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers in Immunology vol. 11,
10.3389/fimmu.2020.00010
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63161
Padovan MG, Norling LV(2020). Pro-resolving lipid mediators in sepsis and critical illness. Current Opinion in Clinical Nutrition and Metabolic Care1-1.
10.1097/mco.0000000000000633
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62319
Oggero S, Austin-Williams S, Norling LV(2019). The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. Frontiers in Pharmacology vol. 10,
10.3389/fphar.2019.01479
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62780
Oggero S, Van Gorp R, Norling LV, Schurgers L, Reutelingsperger C, Perretti M (2019). Stimulation of monocyte-platelet aggregation drives formation of microvesicle subsets to promote vascular inflammation. BRITISH JOURNAL OF PHARMACOLOGY. vol. 176, 3032-3033.
Oggero S, Van Gorp R, Cooper D, Norling L, Schurgers L, Reutelinsperger C, Perretti M (2019). Monocyte and not Neutrophil derived microvesicles are able to activate endothelial cells and smooth muscle cells and to enhance recruitment of PMN in a Flow Chamber based assay. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. vol. 49, 198-199.
Topping LM, Vinci C, Rhys H, Norling L, Nissim A (2018). TARGETING NEUTROPHIL MICROVESICLES TO DAMAGED CARTILAGE USING ANTIBODIES TO POST-TRANSLATIONALLY MODIFIED COLLAGEN II. ANNALS OF THE RHEUMATIC DISEASES. vol. 77, 179-179.
10.1136/annrheumdis-2018-eular.6744
Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M (2018). NEUTROPHIL EXTRACELLULAR VESICLES HAVE A CARTILAGE PROTECTIVE EFFECT DURING INFLAMMATORY ARTHRITIS. OSTEOARTHRITIS AND CARTILAGE. vol. 26, S125-S126.
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M(2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine vol. 29, 60-69.
10.1016/j.ebiom.2018.02.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36528
Perretti M, Norling LV(2017). Actions of SPM in regulating host responses in arthritis. Molecular Aspects of Medicine vol. 58, 57-64.
10.1016/j.mam.2017.04.005
Topping LM, Rhys H, Norling L, Nissim A (2017). TARGETING NEUTROPHIL MICROVESICLES TO DAMAGED CARTILAGE USING ANTIBODIES TO POST TRANSLATIONALLY MODIFIED COLLAGEN II. ANNALS OF THE RHEUMATIC DISEASES. vol. 76, 483-484.
10.1136/annrheumdis-2017-eular.4842
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ et al.(2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Journal of Ethnopharmacology vol. 204, 179-188.
10.1016/j.jep.2017.03.059
Norling LV, Ly L, Dalli J(2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care vol. 20, (2) 145-152.
10.1097/MCO.0000000000000353
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18759
Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ et al.(2017). Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. Annals of the Rheumatic Diseases vol. 76, (3) 612-619.
10.1136/annrheumdis-2016-209424
Perretti M, Cooper D, Dalli J, Norling LV(2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol vol. 13, (2) 87-99.
10.1038/nrrheum.2016.193
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18889
Souza PR, Jones HR, Norling LV(2017). Novel immunoregulatory mediators produced from omega-3 fatty acids. Nutrition, Immunity, and Infection,
Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV, Cooper D(2016). Galectin-3-null mice display defective neutrophil clearance during acute inflammation. J Leukoc Biol
10.1189/jlb.3A0116-026RR
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18859
Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CN(2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. Journal of Immunology vol. 197, (6) 2362-2368.
10.4049/jimmunol.1502268
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23490
Souza PR, Norling LV(2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology vol. 785, Article C, 165-173.
10.1016/j.ejphar.2015.05.072
Norling L, Headland S, Dalli J, Arnardottir H, Jones H, Haworth O, Serhan C, Perretti M (2016). PRO-RESOLVING AND CARTILAGE-PROTECTIVE ACTIONS OF RESOLVIN D1 IN INFLAMMATORY ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. Conference: EULAR vol. 75, 673-673.
10.1136/annrheumdis-2016-eular.6116
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24545
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN et al.(2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight vol. 1, (5)
10.1172/jci.insight.85922
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12017
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al.(2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Science Translational Medicine vol. 7, (315)
10.1126/scitranslmed.aac5608
Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB et al.(2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Journal of Controlled Release vol. 217, 284-292.
10.1016/j.jconrel.2015.09.021
Headland SE, Norling LV(2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology vol. 27, (3) 149-160.
10.1016/j.smim.2015.03.014
Headland S, Norling L, Kim A, Jones H, Jan L, Perretti M(2015). Neutrophil-Derived Microvesicles Migrate into Cell-Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. FASEB JOURNAL vol. 29,
Headland SE, Norling LV(2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology
10.1016/j.smim.2015.03.014
Ross EA, Smallie T, Naylor AJ, Desanti GE, Crowe J, O'Neil JD, Turner JD, Yemm A et al. (2015). TRISTETRAPROLIN IS A NOVEL THERAPEUTIC TARGET FOR RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, A81-A81.
10.1136/annrheumdis-2015-207259.186
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA, Perretti M(2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341.
10.1016/j.ajpath.2014.04.009
https://qmro.qmul.ac.uk/xmlui/handle/123456789/43046
Cash JL, Norling LV, Perretti M(2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today vol. 19, (8) 1186-1192.
10.1016/j.drudis.2014.06.023
Headland SE, Jones HR, D'Sa ASV, Perretti M, Norling LV(2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4,
10.1038/srep05237
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10076
Headland S, Norling L, Patel H, Dalli J, Kelly S, Pitzalis C, Dell'Accio F, Perretti M (2014). A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage. FASEB JOURNAL. vol. 28,
10.1096/fasebj.28.1_supplement.146.8
Norling L, Headland S, Dalli J, Serhan C, Perretti M (2014). Resolvin D1 protects from neutrophil mediated joint destruction in inflammatory arthritis. FASEB JOURNAL. vol. 28,
10.1096/fasebj.28.1_supplement.146.5
Burgmaier M, Schutters K, Willems B, van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL et al.(2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE<sup>-/-</sup> mice. Journal of Cellular and Molecular Medicine vol. 18, (10) 2117-2124.
10.1111/jcmm.12374
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ et al.(2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med vol. 6, (1) 27-42.
10.1002/emmm.201303503
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10756
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M(2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219.
10.1074/mcp.M113.028589
Norling LV, Dalli J(2013). Microparticles are novel effectors of immunity. Curr Opin Pharmacol vol. 13, (4) 570-575.
10.1016/j.coph.2013.05.008
Norling LV, Perretti M(2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol vol. 13, (3) 476-481.
10.1016/j.coph.2013.02.003
Perretti M, Dalli J, Norling LV, Montero-Melendez T, Hinds C (2013). Neutrophil Microparticles are heterogenous in content and function. FASEB JOURNAL. vol. 27,
10.1096/fasebj.27.1_supplement.138.5
Norling LV, Perretti M (2013). Omega-3 derived Resolvin D1 reduces the severity of inflammatory arthritis. FASEB JOURNAL. vol. 27,
Norling LV, Perretti M(2013). Control of myeloid cell trafficking in resolution. J Innate Immun vol. 5, (4) 367-376.
10.1159/000350612
Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M, Cadavid A(2012). Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids vol. 87, (4-5) 127-134.
10.1016/j.plefa.2012.08.003
Yazid S, Norling LV, Flower RJ(2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system. Prostaglandins Other Lipid Mediat vol. 98, (3-4) 94-100.
10.1016/j.prostaglandins.2011.11.005
Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M(2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978.
10.1161/ATVBAHA.112.249508
Norling L, Dalli J, Flower R, Serhan C, Perretti M (2012). RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS. RHEUMATOLOGY. vol. 51, 47-48.
Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M (2012). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. FASEB JOURNAL. vol. 26,
10.1096/fasebj.26.1_supplement.835.17
Norling LV, Dalli J, Serhan CN, Perretti M (2011). RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS. INFLAMMATION RESEARCH. vol. 60, 60-60.
Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN(2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J IMMUNOL vol. 186, (10) 5543-5547.
10.4049/jimmunol.1003865
Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN(2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol vol. 186, (10) 5543-5547.
10.4049/jimmunol.1003865
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D, Perretti M(2010). Human RCAN3 gene expression and cell growth in endothelial cells. INT J MOL MED vol. 26, (6) 913-918.
10.3892/ijmm_00000542
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D, Perretti M(2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918.
10.3892/ijmm_00000542
Norling LV, Serhan CN(2010). Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med vol. 268, (1) 15-24.
10.1111/j.1365-2796.2010.02235.x
Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M(2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. FASEB JOURNAL vol. 24,
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M et al.(2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature vol. 461, (7268) 1287-1291.
10.1038/nature08541
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19168
Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y, Bishop-Bailey D(2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J LEUKOCYTE BIOL vol. 86, (1) 115-122.
10.1189/JLB.0508284
Norling LV, Perretti M, Cooper D(2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol vol. 201, (2) 169-184.
10.1677/JOE-08-0512
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY, Perretti M(2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. BLOOD vol. 112, (6) 2512-2519.
10.1182/blood-2008-02-140533
Cooper D, Norling LV, Perretti M(2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol vol. 83, (6) 1459-1466.
10.1189/jlb.1207831
Dasgupta B, Dalli J, Norling L, Pederzoli-Ribeil M, Hollywood J, D'Acquisto F, Perretti M (2008). Altered expression of annexin 1 and its receptor in neutrophils of patients with giant cell arteritis (GCA) and ANCA associated vasculitis (AAV). RHEUMATOLOGY. vol. 47, II99-II99.
Norling LV, Sampaio ALF, Cooper D, Perretti M(2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J vol. 22, (3) 682-690.
10.1096/fj.07-9268com
Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ et al.(2007). Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. MOL PHARMACOL vol. 72, (5) 1132-1136.
10.1124/mol.107.037325
Norling LV, Cooper D, Perretti M (2006). Endogenous Galectn-1 inhibits lymphocyte-endothelial cell interactions as determined by small interference RNA. FASEB JOURNAL. vol. 20, A647-A647.
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