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Publications:  Dr Eleni Maniati

Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al.(2020). Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Cell Reports vol. 30, (2) 525-540.e7.
10.1016/j.celrep.2019.12.034
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62723
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.(2019). Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. Journal of Pathology vol. 249, (4) 523-535.
10.1002/path.5340
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59784
Spear S, Candido JB, McDermott JR, Ghirelli C, Maniati E, Beers SA, Balkwill FR, Kocher HM et al.(2019). Discrepancies in the tumor microenvironment of spontaneous and orthotopic murine models of pancreatic cancer uncover a new immunostimulatory phenotype for B cells. Frontiers in Immunology vol. 10, (MAR)
10.3389/fimmu.2019.00542
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61445
Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al. (2018). Investigating drivers of the tumour matrisome, and their role in disease progression. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 99, A49-A49.
Lecker LSM, Trevisan C, Delaine-Smith R, Maniati E, Pearce O, Meinert C, Iwanicki M, Drapkin R et al. (2018). Mutant p53 increases integrin-ECM interactions in early HGSOC. CLINICAL CANCER RESEARCH. vol. 24, 54-54.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.(2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov
10.1158/2159-8290.CD-17-0284
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30984
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M (2017). Deconstruction of a human tumor microenvironment. CANCER RESEARCH. vol. 77,
10.1158/1538-7445.AM2017-5558
BALKWILL F, Berlato C, Khan MN, Schioppa T, Thompson R, Maniati E, Montfort A, Jangani M et al.(2017). A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer. Journal of Clinical Investigation
10.1172/JCI82976
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18188
Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH et al.(2016). A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases. Clinical Cancer Research
10.1158/1078-0432.CCR-16-0081
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13383
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al.(2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. Cancer Research
10.1158/0008-5472.CAN-16-0481
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12978
Serrels A, Lund T, Serrels B, Byron A, McPherson RC, Von Kriegsheim A, Gómez-Cuadrado L, Canel M et al.(2015). Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity. Cell vol. 163, (1) 160-173.
10.1016/j.cell.2015.09.001
Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al.(2015). A vaccinia virus armed with interleukin-10 Is a promising therapeutic agent for treatment of murine pancreatic cancer. Clinical Cancer Research vol. 21, (2) 405-416.
10.1158/1078-0432.CCR-14-0464
Berlato C, Kahn MN, Schioppa T, Thompson R, Maniati E, Canosa M, Kulbe H, Sheldon C et al. (2014). Antagonists of the chemokine receptor CCR4 reverse the tumor-promoting microenvironment of renal cancer. CANCER RESEARCH. vol. 74,
10.1158/1538-7445.AM2014-1076
Batista S, Maniati E, Reynolds LE, Tavora B, Lees DM, Fernandez I, Elia G, Casanovas O et al.(2014). Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis. Nat Commun vol. 5,
10.1038/ncomms6054
Popov N, Maniati E, Marzec J, Okosun J, Scott R, Kranz A, Stewart F, Chelala C et al. (2013). Investigating The Role Of MLL2 (Mll4) In B Cell Development. BLOOD. vol. 122,
10.1182/blood.V122.21.343.343
Maniati E, Hagemann T(2013). IL-17 mediates resistance to anti-VEGF therapy. Nat Med vol. 19, (9) 1092-1094.
10.1038/nm.3333
Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. (2013). A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer. MOLECULAR THERAPY. vol. 21, S196-S196.
Neyen C, Plüddemann A, Mukhopadhyay S, Maniati E, Bossard M, Gordon S, Hagemann T(2013). Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer. J Immunol vol. 190, (7) 3798-3805.
10.4049/jimmunol.1203194
Cappuccini F, Wirsdoerfer F, Maniati E, Hagemann T, Stuschke M, Jendrossek V (2012). Potential Role of Lymphocytes During DNA Damage-induced Pneumopathy. EUROPEAN JOURNAL OF CANCER. vol. 48, S269-S269.
10.1016/S0959-8049(12)71719-7
Cappuccini F, Wirsdoerfer F, Maniati E, Hagemann T, Westendorf A, Stuschke M, Jendrossek V (2012). Lymphocytes play a role in radiation-induced pneumopathy. STRAHLENTHERAPIE UND ONKOLOGIE. vol. 188, 126-127.
Emami-Shahri N, Maniati E, Bossard M, Hagemann T(2012). Metformin suppresses the growth and modulates the metabolic profiles of pancreatic cancer cells under hypoxia in an IKK alpha-dependent manner. CANCER RESEARCH vol. 72,
10.1158/1538-7445.AM2012-3209
Maniati E, Bossard M, Cook N, Candido J, Emami-Shahri N, Nedospasov S, Balkwill F, Tuveson D et al. (2011). Cross-talk between IKK2 and Notch promotes pancreatic cancer progression in mice through Hes1 mediated PPAR gamma inhibitio. IMMUNOLOGY. vol. 135, 169-169.
Maniati E, Bossard M, Cook N, Candido JB, Emami-Shahri N, Nedospasov SA, Balkwill FR, Tuveson DA et al.(2011). Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest vol. 121, (12) 4685-4699.
10.1172/JCI45797
Hallam SL, Candido J, Coutinho R, Maniati E, Thompson RG, van Rooijen N, Hagemann T, Gribben JG (2011). Manipulating Tumor Associated Macrophages (TAM) in a Mouse Model of B-Cell Non-Hodgkin Lymphoma (NHL). BLOOD. vol. 118, 720-720.
Maniati E, Soper R, Hagemann T(2010). Up for Mischief? IL-17/Th17 in the tumour microenvironment. Oncogene vol. 29, (42) 5653-5662.
10.1038/onc.2010.367
Rogers NJ, Lees MJ, Gabriel L, Maniati E, Rose SJ, Potter PK, Morley BJ(2009). A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells. J Immunol vol. 182, (4) 1982-1990.
10.4049/jimmunol.0801320
Maniati E, Aw D, Palmer DB, Morley BJ, Rogers NJ (2008). Alterations of the thymic environment in murine models of SLE. IMMUNOLOGY. vol. 125, 113-113.
Gabriel L, Maniati E, Morley BJ, Rogers NJ (2008). The role of NKT cells in the immunopathology of systemic lupus erythematosus. IMMUNOLOGY. vol. 125, 111-111.
Maniati E, Gomes MJ, Gabriel L, Morley BJ, Rogers NJ (2008). The role of toll-like receptors in the BXSB model of SLE. IMMUNOLOGY. vol. 125, 112-113.
Maniati E, Potter P, Rogers NJ, Morley BJ(2008). Control of apoptosis in autoimmunity. J Pathol vol. 214, (2) 190-198.
10.1002/path.2270
Maniati E, Rogers NJ, Morley BJ (2007). Lymphoid tissue distribution of DC subtypes in a murine model of SLE. IMMUNOLOGY. vol. 120, 73-73.
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