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Publications:  Prof Carol Shoulders

Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN et al.(2019). Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances
10.1126/sciadv.aax9183
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61549
France M, Rees A, Datta D, Thompson G, Capps N, Ferns G, Ramaswami U, Seed M et al.(2016). HEART UK statement on the management of homozygous familial hypercholesterolaemia in the United Kingdom. Atherosclerosis
10.1016/j.atherosclerosis.2016.10.017
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17693
Aikio M, Elamaa H, Vicente D, Izzi V, Kaur I, Seppinen L, Speedy HE, Kaminska D et al.(2014). Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition. Proc Natl Acad Sci U S A vol. 111, (30) E3043-E3052.
10.1073/pnas.1405879111
Fryer LGD, Jones B, Duncan EJ, Hutchison CE, Ozkan T, Williams PA, Alder O, Nieuwdorp M et al.(2014). The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis. J Biol Chem vol. 289, (7) 4244-4261.
10.1074/jbc.M113.479980
Horswell SD, Fryer LGD, Hutchison CE, Zindrou D, Speedy HE, Town M-M, Duncan EJ, Sivapackianathan R et al.(2013). CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients. J Lipid Res vol. 54, (12) 3491-3505.
10.1194/jlr.M041814
Motazacker MM, Peter J, Treskes M, Shoulders CC, Kuivenhoven JA, Hovingh GK(2013). Evidence of a polygenic origin of extreme high-density lipoprotein cholesterol levels. Arterioscler Thromb Vasc Biol vol. 33, (7) 1521-1528.
10.1161/ATVBAHA.113.301505
Salm MPA, Horswell SD, Hutchison CE, Speedy HE, Yang X, Liang L, Schadt EE, Cookson WO et al.(2012). The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism. Genome Res vol. 22, (6) 1144-1153.
10.1101/gr.126037.111
Calandra S, Tarugi P, Speedy HE, Dean AF, Bertolini S, Shoulders CC(2011). Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J LIPID RES vol. 52, (11) 1885-1926.
10.1194/jlr.R017855
Shoulders CC(2010). A new Thematic Series: Genetics of human lipid diseases. J LIPID RES vol. 51, (7) 1621-1623.
10.1194/jlr.E006833
Horswell SD, Ringham HE, Shoulders CC(2009). New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia. J Lipid Res vol. 50 Suppl, S370-S375.
10.1194/jlr.R800081-JLR200
Shoulders CC(2008). The FTO (fat mass and obesity-associated) gene: big in adipocyte lipolysis?. J Lipid Res vol. 49, (3) 495-496.
10.1194/jlr.E700013-JLR200
Lelliott CJ, Ljungberg A, Ahnmark A, William-Olsson L, Ekroos K, Elmgren A, Arnerup G, Shoulders CC et al.(2007). Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation. Arterioscler Thromb Vasc Biol vol. 27, (12) 2707-2713.
10.1161/ATVBAHA.107.155739
Shoulders CC, Shelness GS(2005). Current biology of MTP: implications for selective inhibition. Curr Top Med Chem vol. 5, (3) 283-300.
10.2174/1568026053544560
Shoulders CC, Naoumova RP(2004). USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome. Trends Mol Med vol. 10, (8) 362-365.
10.1016/j.molmed.2004.06.011
Griffin JL, Bonney SA, Mann C, Hebbachi AM, Gibbons GF, Nicholson JK, Shoulders CC, Scott J(2004). An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver. Physiol Genomics vol. 17, (2) 140-149.
10.1152/physiolgenomics.00158.2003
Shoulders CC, Jones EL, Naoumova RP(2004). Genetics of familial combined hyperlipidemia and risk of coronary heart disease. Hum Mol Genet vol. 13 Spec No 1, R149-R160.
10.1093/hmg/ddh069
Shoulders CC, Stephens DJ, Jones B(2004). The intracellular transport of chylomicrons requires the small GTPase, Sar1b. Curr Opin Lipidol vol. 15, (2) 191-197.
10.1097/00041433-200404000-00012
Mensenkamp AR, Van Luyn MJA, Havinga R, Teusink B, Waterman IJ, Mann CJ, Elzinga BM, Verkade HJ et al.(2004). The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice. Journal of Hepatology vol. 40, (4) 599-606.
10.1016/j.jhep.2003.12.011
Shoulders CC(2004). USF1 on trial. Nature Genetics vol. 36, (4) 322-323.
10.1038/ng0404-322
Shoulders CC, Naoumova RP(2004). The genes and proteins of atherogenic lipoprotein production. Biochemical Society Transactions vol. 32, (1) 70-74.
10.1042/BST0320070
Shoulders CC, Naoumova RP(2004). The genes and proteins of atherogenic lipoprotein production. Biochem Soc Trans vol. 32, (Pt 1) 70-74.
10.1042/bst0320070
Eichenbaum-Voline S, Olivier M, Jones EL, Naoumova RP, Jones B, Gau B, Patel HN, Seed M et al.(2004). Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia. ARTERIOSCL THROM VAS vol. 24, (1) 167-174.
10.1161/01.ATV.0000099881.83261.D4
Naoumova RP, Bonney SA, Eichenbaum-Voline S, Patel HN, Jones B, Jones EL, Amey J, Colilla S et al.(2003). Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia. ARTERIOSCL THROM VAS vol. 23, (11) 2070-2077.
10.1161/01.ATV.0000095975.35247.9F
Jones B, Jones EL, Bonney SA, Patel HN, Mensenkamp AR, Eichenbaum-Voline S, Rudling M, Myrdal U et al.(2003). Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet vol. 34, (1) 29-31.
10.1038/ng1145
Levy E, Stan S, Delvin E, Ménard D, Shoulders C, Garofalo C, Slight I, Seidman E et al.(2002). Localization of microsomal triglyceride transfer protein in the Golgi. Possible role in the assembly of chylomicrons. Journal of Biological Chemistry vol. 277, (19) 16470-16477.
10.1074/jbc.M102385200
Griffin JL, Mann CJ, Scott J, Shoulders CC, Nicholson JK(2001). Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes. FEBS Lett vol. 509, (2) 263-266.
10.1016/s0014-5793(01)03175-1
Roosbeek S, Vanloo B, Duverger N, Caster H, Breyne J, De Beun I, Patel H, Vandekerckhove J et al.(2001). Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferase. J Lipid Res vol. 42, (1) 31-40.
Read J, Anderson TA, Ritchie PJ, Vanloo B, Amey J, Levitt D, Rosseneu M, Scott J et al.(2000). A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein. J Biol Chem vol. 275, (39) 30372-30377.
10.1074/jbc.C000364200
Scott J, Shoulders C, Navaratnam N, Aitman T(2000). The genetics of the metabolic overlap syndrome. Proc Nutr Soc vol. 59, (3)
10.1017/s0029665100000598
Ritchie PJ, Decout A, Amey J, Mann CJ, Read J, Rosseneu M, Scott J, Shoulders CC(1999). Baculovirus expression and biochemical characterization of the human microsomal triglyceride transfer protein. Biochem J vol. 338 ( Pt 2), 305-310.
10.1042/0264-6021:3380305
Bradbury P, Mann CJ, Köchl S, Anderson TA, Chester SA, Hancock JM, Ritchie PJ, Amey J et al.(1999). A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase. J Biol Chem vol. 274, (5) 3159-3164.
10.1074/jbc.274.5.3159
Nicodeme E, Benoist F, McLeod R, Yao Z, Scott J, Shoulders CC, Grand-Perret T(1999). Identification of domains in apolipoprotein B100 that confer a high requirement for the microsomal triglyceride transfer protein. Journal of Biological Chemistry vol. 274, (4) 1986-1993.
10.1074/jbc.274.4.1986
Mann CJ, Anderson TA, Read J, Chester SA, Harrison GB, Köchl S, Ritchie PJ, Bradbury P et al.(1999). The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins. J Mol Biol vol. 285, (1) 391-408.
10.1006/jmbi.1998.2298
Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM et al.(1999). Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet vol. 21, (1) 76-83.
10.1038/5013
Heath KE, Luong LEA, Leonard JV, Chester A, Shoulders CC, Scott J, Middleton-Price HR, Humphries SE et al.(1997). The use of a highly informative CA repeat polymorphism within the abetalipoproteinaemia locus (4q22-24). Prenatal Diagnosis vol. 17, (12) 1181-1186.
10.1002/(SICI)1097-0223(199712)17:12<1181::AID-PD205>3.0.CO;2-A
Shoulders CC, Grantham TT, North JD, Gaspardone A, Tomai F, de Fazio A, Versaci F, Gioffre PA et al.(1996). Hypertriglyceridemia and the apolipoprotein CIII gene locus: lack of association with the variant insulin response element in Italian school children. Hum Genet vol. 98, (5) 557-566.
10.1007/s004390050259
Webb JC, Patel DD, Shoulders CC, Knight BL, Soutar AK(1996). Genetic variation at a splicing branch point in intron 9 of the low density lipoprotein (LDL)-receptor gene: a rare mutation that disrupts mRNA splicing in a patient with familial hypercholesterolaemia and a common polymorphism. Hum Mol Genet vol. 5, (9) 1325-1331.
10.1093/hmg/5.9.1325
Lamberg A, Jauhiainen M, Metso J, Ehnholm C, Shoulders C, Scott J, Pihlajaniemi T, Kivirikko KI(1996). The role of protein disulphide isomerase in the microsomal triacylglycerol transfer protein does not reside in its isomerase activity. Biochemical Journal vol. 315, (2) 533-536.
10.1042/bj3150533
Narcisi TM, Shoulders CC, Chester SA, Read J, Brett DJ, Harrison GB, Grantham TT, Fox MF et al.(1995). Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia. Am J Hum Genet vol. 57, (6) 1298-1310.
Leiper JM, Bayliss JD, Pease RJ, Brett DJ, Scott J, Shoulders CC(1994). Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells. J Biol Chem vol. 269, (35) 21951-21954.
Crea F, Gaspardone A, Tomai F, Shoulders C, De Fazio A, Versaci F, Iamele M, Roncaglioni C et al.(1994). Risk factors in schoolchildren associated with a family history of unheralded myocardial infarction or uncomplicated stable angina in male relatives. J Am Coll Cardiol vol. 23, (6) 1472-1478.
10.1016/0735-1097(94)90394-8
SHOULDERS CC, NARCISI TME, READ J, CHESTER SA, BRETT DJ, SCOTT J, ANDERSON TA, LEVITT DG et al.(1994). THE ABETALIPOPROTEINEMIA GENE IS A MEMBER OF THE VITELLOGENIN FAMILY AND ENCODES AN ALPHA-HELICAL DOMAIN. NATURE STRUCTURAL BIOLOGY vol. 1, (5) 285-286.
10.1038/nsb0594-285
Shoulders CC(1994). Genetics and molecular biology. Current Opinion in Lipidology vol. 5, (1)
Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S et al.(1993). Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein. Hum Mol Genet vol. 2, (12) 2109-2116.
10.1093/hmg/2.12.2109
Castro Cabezas M, de Bruin TW, de Valk HW, Shoulders CC, Jansen H, Willem Erkelens D(1993). Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance. J Clin Invest vol. 92, (1) 160-168.
10.1172/JCI116544
Shoulders CC(1993). Genetics and molecular biology. Current Opinion in Lipidology vol. 4, (1)
Shoulders CC(1991). Genetics and molecular biology. Current Opinion in Lipidology vol. 2, (4)
10.1097/00041433-199108000-00011
Shoulders CC(1990). Genetics and molecular biology. Current Opinion in Lipidology vol. 1, (6) 544-547.
10.1097/00041433-199012000-00011
Shoulders CC(1990). Genetics and molecular biology: Editorial comment. Current Opinion in Lipidology vol. 1, (4) 371-373.
10.1097/00041433-199008000-00010
Shoulders CC, Ball MJ, Baralle FE(1989). Variation in the apo AI/CIII/AIV gene complex: its association with hyperlipidemia. Atherosclerosis vol. 80, (2) 111-118.
10.1016/0021-9150(89)90018-x
Jenner K, Sidoli A, Ball M, Rodriguez JR, Pagani F, Giudici G, Vergani C, Mann J et al.(1988). Characterization of genetic markers in the 3' end of the apo B gene and their use in family and population studies. Atherosclerosis vol. 69, (1) 39-49.
10.1016/0021-9150(88)90287-0
Shoulders CC, Ball MJ, Mann JI, Baralle FE, Ferns GAA, Stocks J, Galton DJ(1986). GENETIC MARKER IN APOLIPOPROTEIN AI/CIII GENE COMPLEX ASSOCIATED WITH HYPERCHOLESTEROLAEMIA. The Lancet vol. 328, (8518) 1286-1287.
10.1016/S0140-6736(86)92719-4
SHOULDERS CC, BARALLE FE(1986). GENETIC-POLYMORPHISM IN THE APOA-I/C-III COMPLEX. METHODS IN ENZYMOLOGY vol. 128, 727-745.
10.1016/0076-6879(86)28102-1
BARALLE FE, SHOULDERS CC(1985). APOLIPOPROTEIN GENES, DNA POLYMORPHISMS AND HYPERLIPIDEMIA. BULLETIN OF MOLECULAR BIOLOGY AND MEDICINE vol. 10, (4) 343-358.
Shelley CS, Sharpe CR, Baralle FE, Shoulders CC(1985). Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction. Journal of Molecular Biology vol. 186, (1) 43-51.
10.1016/0022-2836(85)90255-4
REES A, STOCKS J, SHARPE CR, VELLA MA, SHOULDERS CC, KATZ J, JOWETT NI, BARALLE FE et al.(1985). DEOXYRIBONUCLEIC-ACID POLYMORPHISM IN THE APOLIPOPROTEIN-A-1-C-III GENE-CLUSTER - ASSOCIATION WITH HYPERTRIGLYCERIDEMIA. J CLIN INVEST vol. 76, (3) 1090-1095.
10.1172/JCI112062
Shoulders CC, Myant NB, Sidoli A, Rodriguez JC, Cortese C, Baralle FE, Cortese R(1985). Molecular cloning of human LDL apolipoprotein B cDNA. Evidence for more than one gene per haploid genome. Atherosclerosis vol. 58, (1-3) 277-289.
10.1016/0021-9150(85)90073-5
Sharpe CR, Sidoli A, Shelley CS, Lucero MA, Shoulders CC, Baralle FE(1984). Human apohpoprotetas AI, AII, CII and CIII. cDNA sequences and mRNA abundance. Nucleic Acids Research vol. 12, (9) 3917-3932.
10.1093/nar/12.9.3917
SHARPE CR, SIDOLI A, SHELLEY CS, LUCERO MA, SHOULDERS CC, BARALLE FE(1984). HUMAN APOLIPOPROTEIN-A-I, APOLIPOPROTEIN-AII, APOLIPOPROTEIN-CII AND APOLIPOPROTEIN-CIII - CDNA SEQUENCES AND MESSENGER-RNA ABUNDANCE. NUCLEIC ACIDS RESEARCH vol. 12, (9) 3917-3932.
10.1093/nar/12.9.3917
Baralle FE, Shoulders CC(1984). Lipoprotein genes and hyperlipidemia. Schweizerische Medizinische Wochenschrift vol. 114, (40) 1351-1358.
REES A, STOCKS J, SCHOULDERS C, CARLSON LA, BARALLE FE, GALTON DJ(1984). RESTRICTION ENZYME ANALYSIS OF THE APOLIPOPROTEIN A-I-GENE IN FISH EYE DISEASE AND TANGIER DISEASE. ACTA MEDICA SCANDINAVICA vol. 215, (3) 235-237.
10.1111/j.0954-6820.1984.tb05000.x
Shoulders CC, Kornblihtt AR, Munro BS, Baralle FE(1983). Gene structure of human apolipoprotein Al. Nucleic Acids Research vol. 11, (9) 2827-2837.
10.1093/nar/11.9.2827
REES A, SHOULDERS CC, STOCKS J, GALTON DJ(1983). DNA POLYMORPHISM ADJACENT TO HUMAN APOPROTEIN-A-1 GENE - RELATION TO HYPERTRIGLYCERIDEMIA. LANCET vol. 1, (8322) 444-446.
10.1016/s0140-6736(83)91440-x
Shoulders CC, Baralle FE(1982). Isolation of the human HDL apoprotein A1 gene. Nucleic Acids Research vol. 10, (16) 4873-4882.
10.1093/nar/10.16.4873
Di Segni G, Carrara G, Tocchini-Valentini GR, Shoulders CC, Baralle FE(1981). Selective in vitro transcription of one of the two alu family repeats present in the 5′ flanking region of the human ε-globin gene. Nucleic Acids Research vol. 9, (24) 6709-6722.
10.1093/nar/9.24.6709
Baralle FE, Shoulders CC, Goodbourn S, Jeffreys A, Proudfoot NJ(1980). The 5′ flanking region of human ε-globin gene. Nucleic Acids Research vol. 8, (19) 4393-4404.
10.1093/nar/8.19.4393
EFSTRATIADIS A, POSAKONY JW, MANIATIS T, LAWN RM, OCONNELL C, SPRITZ RA, DERIEL JK, FORGET BG et al.(1980). THE STRUCTURE AND EVOLUTION OF THE HUMAN BETA-GLOBIN GENE FAMILY. CELL vol. 21, (3) 653-668.
10.1016/0092-8674(80)90429-8
Baralle FE, Shoulders CC, Proudfoot NJ(1980). The primary structure of the human ϵ-globin gene. Cell vol. 21, (3) 621-626.
10.1016/0092-8674(80)90425-0
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