Publications:  Dr John Riches

Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, Martin Moro F, Razanamahery J et al.(2020). Outcomes of patients with hematologic malignancies and COVID-19: A systematic review and meta-analysis of 3377 patients. Blood

Aries JA, Davies JK, Auer RL, Hallam SL, Montoto S, Smith M, Sevillano B, Foggo V et al.(2020). Clinical Outcome of Coronavirus Disease 2019 in Haemato-oncology Patients. British Journal of Haematology

Clear AJ, D'Avola A, Agrawal SG, Rassenti LZ, Kipps TJ, Gribben JG, Riches J (2018). B-Cell Receptor Signaling Drives Glycolysis in Chronic Lymphocytic Leukemia Cells. Blood. vol. 132, 3121-3121.

Riches JC, Gribben JG(2016). Mechanistic and clinical aspects of lenalidomide treatment for chronic lymphocytic leukemia. Current Cancer Drug Targets vol. 16,

McClanahan F, Riches JC, Miller S, Day WP, Kotsiou E, Neuberg D, Croce CM, Capasso M et al.(2015). Mechanisms of PD-L1/PD-1 mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eμ-TCL1 CLL mouse model. Blood vol. 126, (2) 212-221.

McClanahan F, Riches JC, Miller S, Ghazaly E, Day W, Capasso M, Gribben J(2014). PD-1/PD-L1 mediated T-cell dysfunction in CLL is not absolute and can be at least partially reversed in vivo by the immune-modulatory drug lenalidomide. ONCOLOGY RESEARCH AND TREATMENT vol. 37, 236-236.

Riches JC, Gribben JG(2014). Immunomodulation and immune reconstitution in chronic lymphocytic leukemia. Semin Hematol vol. 51, (3) 228-234.

Riches JC, O'Donovan CJ, Kingdon SJ, McClanahan F, Clear AJ, Neuberg DS, Werner L, Croce CM et al.(2014). Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations. BLOOD vol. 123, (26) 4101-4110.

Riches JC, O'Donovan CJ, Kingdon SJ, McClanahan F, Clear AJ, Neuberg DS, Werner L, Croce CM et al. (2014). Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations. Blood. vol. 123, 4101-4110.

Riches JC, Gribben JG(2014). Hanging tough: CMV-specific CD8+ T cells in CLL. Blood vol. 123, (5) 608-609.

Riches JC, Gribben JG(2013). Advances in chimeric antigen receptor immunotherapy for chronic lymphocytic leukemia. Discov Med vol. 16, (90) 295-302.

Chen S-S, Herndon TM, Emson C, Riches JC, McClanahan F, Tong T, Yan X-J, Patten PEM et al. (2013). Intraclonal Complexity Of CLL Fractions In Cell Proliferation Rates, Gene Expression Signatures, and Responses To Autologous T-Cell Help In Peripheral blood and Secondary Lymphoid Tissues. Blood. vol. 122, 115-115.

Riches JC, Sangaralingam A, Chaplin T, McClanahan F, Iqbal S, Agrawal SG, Ramsay AG, Gribben J(2013). NK Cells From CLL Patients Exhibit Down-Regulation Of Interferon Response Genes That Can Be Reversed With Lenalidomide. Blood vol. 122, (21) 4131-4131.

McClanahan F, Miller S, Riches JC, Ghazaly E, Day WP, Capasso M, Gribben J(2013). T-Cell Dysfunction In CLL Is Mediated Not Only By PD-1/PD-L1 But Also By PD-1/PD-L2 Interactions - Partial Functionality Is Maintained In PD-1 Defined CD8 Subsets and This Can Be Further Promoted By Ibrutinib Treatment. Blood vol. 122, (21) 4120-4120.

O'Donovan CJ, Ramsay AG, McClanahan F, Rassenti L, Kipps TJ, Gribben J, Riches JC(2013). Trisomy 12 CLL Cells Have High Surface Expression Of Integrins Involved In Lymphocyte Trafficking But This Does Not Translate Into Improved LFA-1-Mediated Motility. Blood vol. 122, (21) 4159-4159.

Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al.(2013). Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology vol. 145, (5) 1121-1132.

Riches JC, Gribben JG(2013). Understanding the immunodeficiency in chronic lymphocytic leukemia: potential clinical implications. Hematol Oncol Clin North Am vol. 27, (2) 207-235.

Riches JC, Davies JK, McClanahan F, Fatah R, Iqbal S, Agrawal S, Ramsay AG, Gribben JG(2013). T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. Blood vol. 121, (9) 1612-1621.

Gribben JG, Riches JC(2013). Immunotherapeutic strategies including transplantation: eradication of disease. Hematology Am Soc Hematol Educ Program vol. 2013, 151-157.

Riches JC, Davies JK, McClanahan F, Fatah R, Iqbal S, Agrawal S, Ramsay AG, Gribben JG(2012). Characterizing Immunophenotypic and Functional Pseudo-Exhaustion in T Cells From CLL Patients: The Impact of Lenalidomide. Blood vol. 120, (21) 564-564.

McClanahan F, Ghirelli C, Greaves P, Riches JC, Coutinho R, Ramsay AG, Gribben JG (2012). Inhibitory Ligands CD200, CD270, CD274 and CD276 Are Expressed On E mu-TCL1 Transgenic Mouse Splenocytes and Are of Potential Relevance to Impaired T-Cell Function in Vivo. BLOOD. vol. 120,

Riches JC, Gribben JG(2012). Less expensive CARs?. Cytotherapy vol. 14, (7) 773-774.

Riches JC, Ramsay AG, Gribben JG(2012). Immune reconstitution in chronic lymphocytic leukemia. Curr Hematol Malig Rep vol. 7, (1) 13-20.

Riches JC, Ramsay AG, Gribben JG(2012). Immune dysfunction in chronic lymphocytic leukemia: the role for immunotherapy. Curr Pharm Des vol. 18, (23) 3389-3398.

Riches JC, Sangaralingam A, Kiaii S, Chaplin T, Cekdemir D, Iqbal S, Ramsay AG, Gribben JG(2011). Impact of Lenalidomide on Gene Expression Profiles of Malignant and Immune Cells in Patients with Chronic Lymphocytic Leukemia. Blood vol. 118, (21) 976-976.

Riches JC, Davies J, Iqbal S, Fatah R, Agrawal S, Ramsay AG, Gribben JG(2011). T-Cells From Patients with CLL Exhibit Phenotypic and Transcription Factor Profiles of Exhaustion Independent of CMV Serostatus. Blood vol. 118, (21) 1780-1780.

Riches JC, Ramsay AG, Gribben JG(2011). Chronic lymphocytic leukemia: an update on biology and treatment. Curr Oncol Rep vol. 13, (5) 379-385.

Riches JC, Davies J, Iqbal S, Fatah R, Agrawal S, Ramsay AG, Gribben JG (2011). T-cells from Patients With CLL Exhibit Phenotypic and Transcription Factor Profiles Of Exhaustion Independent of CMV Serostatus. Blood. vol. 118, 1780-1783.

Riches JC, Ramsay AG, Gribben JG(2010). T-cell function in chronic lymphocytic leukaemia. Semin Cancer Biol vol. 20, (6) 431-438.

Riches JC, Gribben JG(2009). Interesting times in the diagnosis and treatment of CLL. Oncology (Williston Park) vol. 23, (12) 1043-1046.