Publications:  Dr Gianvito Martino

Uccelli A, Laroni A, Brundin L, Clanet M, Fernandez O, Nabavi SM, Muraro PA, Oliveri RS et al.(2019). MEsenchymal StEm cells for Multiple Sclerosis (MESEMS): A randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis. Trials vol. 20, (1)

Spinelli A, Girelli M, Arosio D, Polito L, Podini P, Martino G, Seneci P, Muzio L et al.(2019). Intracisternal delivery of PEG-coated gold nanoparticles results in high brain penetrance and long-lasting stability. J Nanobiotechnology vol. 17, (1)

Corada M, Orsenigo F, Bhat GP, Conze LL, Breviario F, Cunha SI, Claesson-Welsh L, Beznoussenko GV et al.(2019). Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier. Circ Res vol. 124, (4) 511-525.

Nutma E, Willison H, Martino G, Amor S(2019). Neuroimmunology - the past, present and future. Clin Exp Immunol

Becher J, Simula L, Volpe E, Procaccini C, La Rocca C, D'Acunzo P, Cianfanelli V, Strappazzon F et al.(2018). AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis. Dev Cell vol. 47, (5) 592-607.e6.

Pellegrini S, Manenti F, Chimienti R, Nano R, Ottoboni L, Ruffini F, Martino G, Ravassard P et al.(2018). Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line. Cell Transplant vol. 27, (10) 1548-1560.

Casella G, Colombo F, Finardi A, Descamps H, Ill-Raga G, Spinelli A, Podini P, Bastoni M et al.(2018). Extracellular Vesicles Containing IL-4 Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis. Mol Ther vol. 26, (9) 2107-2118.

Cusimano M, Brambilla E, Capotondo A, De Feo D, Tomasso A, Comi G, D'Adamo P, Muzio L et al.(2018). Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury. J Neuroinflammation vol. 15, (1)

Rossi C, Cusimano M, Zambito M, Finardi A, Capotondo A, Garcia-Manteiga JM, Comi G, Furlan R et al.(2018). Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis article. Cell Death and Disease vol. 9, (2)

Casella G, Finardi A, Descamps H, Colombo F, Maiorino C, Ruffini F, Patrone M, Degano M et al.(2017). IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression. Scientific Reports vol. 7, (1)

Srinivasan S, Severa M, Rizzo F, Menon R, Brini E, Mechelli R, Martinelli V, Hertzog P et al.(2017). Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis. Scientific Reports vol. 7, (1)

De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, Srinivasan S, Farina C et al.(2017). Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity. J Clin Invest vol. 127, (11) 3937-3953.

Guarnieri FC, Bellani S, Yekhlef L, Bergamaschi A, Finardi A, Fesce R, Pozzi D, Monzani E et al.(2017). Synapsin I deletion reduces neuronal damage and ameliorates clinical progression of experimental autoimmune encephalomyelitis. Brain, Behavior, and Immunity

Rossi S, Studer V, Motta C, Polidoro S, Perugini J, Macchiarulo G, Giovannetti AM, Pareja-Gutierrez L et al.(2017). Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. Neurology vol. 89, (13) 1338-1347.

Ottoboni L, Merlini A, Martino G(2017). Neural stem cell plasticity: Advantages in therapy for the injured central nervous system. Frontiers in Cell and Developmental Biology vol. 5, (MAY)

Sebastiani G, Valentini M, Grieco GE, Ventriglia G, Nigi L, Mancarella F, Pellegrini S, Martino G et al.(2017). MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells. Acta Diabetol vol. 54, (3) 265-281.

Srinivasan S, Dario MD, Russo A, Menon R, Brini E, Romeo M, Sangalli F, Costa GD et al.(2017). Dysregulation of MS risk genes and pathways at distinct stages of disease. Neurology: Neuroimmunology and NeuroInflammation vol. 4, (3)

La Spada A, Baronchelli S, Ottoboni L, Ruffini F, Martino G, Convertino N, Ntai A, Steiner T et al.(2016). Cell Line Macroarray: An Alternative High-Throughput Platform to Analyze hiPSC Lines. J Histochem Cytochem vol. 64, (12) 739-751.

Bacigaluppi M, Russo GL, Peruzzotti-Jametti L, Rossi S, Sandrone S, Butti E, De Ceglia R, Bergamaschi A et al.(2016). Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes. J Neurosci vol. 36, (41) 10529-10544.

Mori F, Nisticò R, Nicoletti CG, Zagaglia S, Mandolesi G, Piccinin S, Martino G, Finardi A et al.(2016). RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis. Multiple Sclerosis vol. 22, (11) 1405-1412.

Muzio L, Brambilla V, Calcaterra L, D'Adamo P, Martino G, Benedetti F(2016). Increased neuroplasticity and hippocampal microglia activation in a mice model of rapid antidepressant treatment. Behav Brain Res vol. 311, 392-402.

Merlini A, De Feo D, Radaelli M, Laterza C, Ciceri F, Martino G(2016). Stem Cell-Based Therapies, Remyelination, and Repair Promotion in the Treatment of Multiple Sclerosis. Translational Neuroimmunology in Multiple Sclerosis: From Disease Mechanisms to Clinical Applications,

Casella G, Garzetti L, Gatta AT, Finardi A, Maiorino C, Ruffini F, Martino G, Muzio L et al.(2016). IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo. J Neuroinflammation vol. 13, (1)

Martino G(2016). Bench-to-bedside translation of stem cell therapies: where are we now and where are we going?. Regen Med vol. 11, (4) 347-349.

Solari A, Giordano A, Grasso MG, Confalonieri P, Patti F, Lugaresi A, Palmisano L, Amadeo R et al.(2016). Erratum to: 'Home-based palliative approach for people with severe multiple sclerosis and their carers: Study protocol for a randomized controlled trial' [Trials 16, (2015) 184]. Trials vol. 17, (1)

Ottoboni L, De Feo D, Merlini A, Martino G(2015). Commonalities in immune modulation between mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs). Immunol Lett vol. 168, (2) 228-239.

Rocca MA, Longoni G, Pagani E, Boffa G, Colombo B, Rodegher M, Martino G, Falini A et al.(2015). In vivo evidence of hippocampal dentate gyrus expansion in multiple sclerosis. Hum Brain Mapp vol. 36, (11) 4702-4713.

Rossi S, Motta C, Studer V, Macchiarulo G, Germani G, Finardi A, Furlan R, Martino G et al.(2015). Subclinical central inflammation is risk for RIS and CIS conversion to MS. Mult Scler vol. 21, (11) 1443-1452.

Morini R, Ghirardini E, Butti E, Verderio C, Martino G, Matteoli M(2015). Subventricular zone neural progenitors reverse TNF-alpha effects in cortical neurons. Stem Cell Res Ther vol. 6,

Mozafari S, Laterza C, Roussel D, Bachelin C, Marteyn A, Deboux C, Martino G, Baron-Van Evercooren A(2015). Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice. J Clin Invest vol. 125, (9) 3642-3656.

Mozafari S, Laterza C, Roussel D, Bachelin C, Marteyn A, Deboux C, Martino G, Evercooren AB-V (2015). IPS-derived neural precursors outcompete endogenous cells for cns remyelination. JOURNAL OF NEUROCHEMISTRY. vol. 134, 287-287.

Martino G(2015). THE THERAPEUTIC ROLE OF NEURAL STEM CELLS IN INFLAMMATORY DEMYELINATING BRAIN DISORDERS. Georgian Med News (243) 87-88.

de Ceglia R, Chaabane L, Biffi E, Bergamaschi A, Ferrigno G, Amadio S, Del Carro U, Mazzocchi N et al.(2015). Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate. Brain Behav Immun vol. 45, 263-276.

Canese R, Zoratto F, Altabella L, Porcari P, Mercurio L, de Pasquale F, Butti E, Martino G et al.(2015). Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist. Psychopharmacology (Berl) vol. 232, (1) 75-89.

Rossi S, Motta C, Studer V, Macchiarulo G, Volpe E, Barbieri F, Ruocco G, Buttari F et al.(2014). Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener vol. 9,

Rossi S, Motta C, Studer V, Rocchi C, Macchiarulo G, Barbieri F, Marfia G, Furlan R et al.(2014). Interleukin-8 is associated with acute and persistent dysfunction after optic neuritis. Mult Scler vol. 20, (14) 1841-1850.

Onorati M, Castiglioni V, Biasci D, Cesana E, Menon R, Vuono R, Talpo F, Laguna Goya R et al.(2014). Molecular and functional definition of the developing human striatum. Nat Neurosci vol. 17, (12) 1804-1815.

Agosta F, Dalla Libera D, Spinelli EG, Finardi A, Canu E, Bergami A, Bocchio Chiavetto L, Baronio M et al.(2014). Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease. Ann Neurol vol. 76, (6) 813-825.

Arnò B, Grassivaro F, Rossi C, Bergamaschi A, Castiglioni V, Furlan R, Greter M, Favaro R et al.(2014). Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex. Nat Commun vol. 5,

Radaelli M, Merlini A, Greco R, Sangalli F, Comi G, Ciceri F, Martino G(2014). Autologous bone marrow transplantation for the treatment of multiple sclerosis. Curr Neurol Neurosci Rep vol. 14, (9)

Colombo E, Di Dario M, Capitolo E, Chaabane L, Newcombe J, Martino G, Farina C(2014). Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide. Ann Neurol vol. 76, (3) 325-337.

Mozafari S, Laterza C, Marteyn A, Deboux C, Martino G, Baron-Van Evercooren A (2014). Neural precursors derived from mouse iPS cells extensively remyelinate the demyelinated central nervous system. MULTIPLE SCLEROSIS JOURNAL. vol. 20, 21-22.

Brambilla P, Bellani M, Isola M, Bergami A, Marinelli V, Dusi N, Rambaldelli G, Tansella M et al.(2014). Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia. Transl Psychiatry vol. 4,

Bacigaluppi M, Butti E, Laterza C, De Feo D, Peruzzotti L, Merlini A, Cusimano M, Martino G(2014). Brain Repair: The Role of Endogenous and Transplanted Neural Stem Cells. Neuroinflammation and CNS Disorders,

Mori F, Nicoletti CG, Rossi S, Motta C, Kusayanagi H, Bergami A, Studer V, Buttari F et al.(2014). Growth factors and synaptic plasticity in relapsing-remitting multiple sclerosis. Neuromolecular Med vol. 16, (2) 490-498.

Garzetti L, Menon R, Finardi A, Bergami A, Sica A, Martino G, Comi G, Verderio C et al.(2014). Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs. J Leukoc Biol vol. 95, (5) 817-825.

Cerri F, Salvatore L, Memon D, Boneschi FM, Madaghiele M, Brambilla P, Del Carro U, Taveggia C et al.(2014). Peripheral nerve morphogenesis induced by scaffold micropatterning. Biomaterials vol. 35, (13) 4035-4045.

Greco R, Bondanza A, Vago L, Moiola L, Rossi P, Furlan R, Martino G, Radaelli M et al.(2014). Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica. Ann Neurol vol. 75, (3) 447-453.

Mori F, Nisticò R, Mandolesi G, Piccinin S, Mango D, Kusayanagi H, Berretta N, Bergami A et al.(2014). Interleukin-1β promotes long-term potentiation in patients with multiple sclerosis. Neuromolecular Med vol. 16, (1) 38-51.

Martino G, Butti E, Bacigaluppi M(2014). Neurogenesis or non-neurogenesis: that is the question. J Clin Invest vol. 124, (3) 970-973.

Rossi S, Motta C, Studer V, Barbieri F, Buttari F, Bergami A, Sancesario G, Bernardini S et al.(2014). Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration. Mult Scler vol. 20, (3) 304-312.

Rossi S, Studer V, Motta C, Germani G, Macchiarulo G, Buttari F, Mancino R, Castelli M et al.(2014). Cerebrospinal fluid detection of interleukin-1β in phase of remission predicts disease progression in multiple sclerosis. J Neuroinflammation vol. 11,

Privitera D, Corti V, Alessio M, Volonté MA, Lampasona V, Comi G, Martino G, Franciotta D et al.(2014). Erratum: Proteomic identification of aldolase A as an autoantibody target in patients with atypical movement disorders (Neurol Sci DOI 10.1007/s10072-012-0996-y). Neurological Sciences vol. 35, (2)

Sandrone S, Bacigaluppi M, Galloni MR, Cappa SF, Moro A, Catani M, Filippi M, Monti MM et al.(2014). Weighing brain activity with the balance: Angelo Mosso's original manuscripts come to light. Brain vol. 137, (Pt 2) 621-633.

Butti E, Cusimano M, Bacigaluppi M, Martino G(2014). Neurogenic and non-neurogenic functions of endogenous neural stem cells. Front Neurosci vol. 8,

Mori F, Rossi S, Piccinin S, Motta C, Mango D, Kusayanagi H, Bergami A, Studer V et al.(2013). Synaptic plasticity and PDGF signaling defects underlie clinical progression in multiple sclerosis. J Neurosci vol. 33, (49) 19112-19119.

Peruzzotti-Jametti L, Cambiaghi M, Bacigaluppi M, Gallizioli M, Gaude E, Mari S, Sandrone S, Cursi M et al.(2013). Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke. Stroke vol. 44, (11) 3166-3174.

Mozafari S, Marteyn A, Laterza C, Deboux C, Martino G, Baron-Van Evercooren A (2013). CHARACTERIZATION OF NEURAL PRECURSORS DERIVED FROM MOUSE IPS CELLS: IN VITRO AND IN VIVO AFTER TRANSPLANTATION INTO THE CENTRAL NERVOUS SYSTEM. GLIA. vol. 61, S152-S152.

Maiorino C, Khorooshi R, Ruffini F, Løbner M, Bergami A, Garzetti L, Martino G, Owens T et al.(2013). Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia. Gene Ther vol. 20, (5) 487-496.

Privitera D, Corti V, Alessio M, Volontè MA, Lampasona V, Comi G, Martino G, Franciotta D et al.(2013). Proteomic identification of aldolase A as an autoantibody target in patients with atypical movement disorders. Neurol Sci vol. 34, (3) 313-320.

Delli Carri A, Onorati M, Lelos MJ, Castiglioni V, Faedo A, Menon R, Camnasio S, Vuono R et al.(2013). Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons. Development vol. 140, (2) 301-312.

Grasselli G, Rossi S, Musella A, Gentile A, Loizzo S, Muzio L, Di Sanza C, Errico F et al.(2013). Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis. Br J Pharmacol vol. 168, (2) 502-517.

Ruffini F, Rossi S, Bergamaschi A, Brambilla E, Finardi A, Motta C, Studer V, Barbieri F et al.(2013). Laquinimod prevents inflammation-induced synaptic alterations occurring in experimental autoimmune encephalomyelitis. Multiple Sclerosis Journal vol. 19, (8) 1084-1094.

Laterza C, Merlini A, De Feo D, Ruffini F, Menon R, Onorati M, Fredrickx E, Muzio L et al.(2013). iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF. Nat Commun vol. 4,

Sandrone S, Bacigaluppi M, Galloni MR, Martino G(2012). Angelo Mosso (1846-1910). J Neurol vol. 259, (11) 2513-2514.

Butti E, Bacigaluppi M, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, Musella A et al.(2012). Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain vol. 135, (Pt 11) 3320-3335.

Verderio C, Muzio L, Turola E, Bergami A, Novellino L, Ruffini F, Riganti L, Corradini I et al.(2012). Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol vol. 72, (4) 610-624.

Marinaro C, Pannese M, Weinandy F, Sessa A, Bergamaschi A, Taketo MM, Broccoli V, Comi G et al.(2012). Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1. Cereb Cortex vol. 22, (10) 2415-2427.

Sandrone S, Bacigaluppi M, Galloni MR, Martino G(2012). Angelo Mosso (1846-1910). Journal of Neurology1-2.

Nigro A, Menon R, Bergamaschi A, Clovis YM, Baldi A, Ehrmann M, Comi G, De Pietri Tonelli D et al.(2012). MiR-30e and miR-181d control radial glia cell proliferation via HtrA1 modulation. Cell Death Dis vol. 3,

Kipp M, Victor M, Martino G, Franklin RJM(2012). Endogeneous remyelination: findings in human studies. CNS Neurol Disord Drug Targets vol. 11, (5) 598-609.

Kokaia Z, Martino G, Schwartz M, Lindvall O(2012). Cross-talk between neural stem cells and immune cells: the key to better brain repair?. Nat Neurosci vol. 15, (8) 1078-1087.

De Feo D, Merlini A, Laterza C, Martino G(2012). Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection. Curr Opin Neurol vol. 25, (3) 322-333.

Ruggeri M, Bonetto C, Lasalvia A, De Girolamo G, Fioritti A, Rucci P, Santonastaso P, Neri G et al.(2012). A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial. Trials vol. 13,

Luchetti A, Milani D, Ruffini F, Galli R, Falini A, Quattrini A, Scotti G, Comi G et al.(2012). Monoclonal antibodies conjugated with superparamagnetic iron oxide particles allow magnetic resonance imaging detection of lymphocytes in the mouse brain. Mol Imaging vol. 11, (2) 114-125.

Caragnano M, Tortorella P, Bergami A, Ruggieri M, Livrea P, Specchio LM, Martino G, Trojano M et al.(2012). Monocytes P2X7 purinergic receptor is modulated by glatiramer acetate in multiple sclerosis. J Neuroimmunol vol. 245, (1-2) 93-97.

Rossi S, Lo Giudice T, De Chiara V, Musella A, Studer V, Motta C, Bernardi G, Martino G et al.(2012). Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis. Br J Pharmacol vol. 165, (4) 861-869.

Sandrone S, Bacigaluppi M, Galloni MR, Martino G(2012). Angelo Mosso (1846-1910). Journal of neurology vol. 259, (11) 2513-2514.

Gironi M, Pasquariello N, Franchi S, Pucci M, Martinelli-Boneschi F, Solaro C, Centonze D, Martino G et al.(2012). Comment on "Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis". Brain Pathol vol. 22, (1)

Rossi S, Furlan R, De Chiara V, Motta C, Studer V, Mori F, Musella A, Bergami A et al.(2012). Interleukin-1β causes synaptic hyperexcitability in multiple sclerosis. Ann Neurol vol. 71, (1) 76-83.

Cusimano M, Biziato D, Brambilla E, Doneg M, Alfaro-Cervello C, Snider S, Salani G, Pucci F et al.(2012). Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord. Brain vol. 135, (2) 447-460.

Rossi S, Mancino R, Bergami A, Mori F, Castelli M, De Chiara V, Studer V, Mataluni G et al.(2011). Potential role of IL-13 in neuroprotection and cortical excitability regulation in multiple sclerosis. Mult Scler vol. 17, (11) 1301-1312.

Martino G, Pluchino S, Bonfanti L, Schwartz M(2011). Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol Rev vol. 91, (4) 1281-1304.

Rossi S, Furlan R, De Chiara V, Muzio L, Musella A, Motta C, Studer V, Cavasinni F et al.(2011). Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. Brain Behav Immun vol. 25, (6) 1242-1248.

Rossi S, Muzio L, De Chiara V, Grasselli G, Musella A, Musumeci G, Mandolesi G, De Ceglia R et al.(2011). Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis. Brain Behav Immun vol. 25, (5) 947-956.

L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Cossetti C, D'Adamo P, Zardini E et al.(2011). Corrigendum to "Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease" [Neurobiol. Dis. 41/2 (2011) 508-527]. Neurobiology of Disease vol. 42, (3)

Martino G, Bacigaluppi M, Peruzzotti-Jametti L(2011). Therapeutic stem cell plasticity orchestrates tissue plasticity. Brain vol. 134, (Pt 6) 1585-1587.

Marinaro C, Butti E, Bergamaschi A, Papale A, Furlan R, Comi G, Martino G, Muzio L(2011). In vivo fate analysis reveals the multipotent and self-renewal features of embryonic AspM expressing cells. PLoS One vol. 6, (4)

Martino G(2011). [We are what we used to be]. Kos vol. 28, (282) 18-32.

L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Cossetti C, D'Adamo P, Zardini E et al.(2011). Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neurobiol Dis vol. 41, (2) 508-527.

Pohl HBF, Porcheri C, Mueggler T, Bachmann LC, Martino G, Riethmacher D, Franklin RJM, Rudin M et al.(2011). Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J Neurosci vol. 31, (3) 1069-1080.

Ferrandi C, Richard F, Tavano P, Hauben E, Barbié V, Gotteland JP, Greco B, Fortunato M et al.(2011). Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Multiple Sclerosis Journal vol. 17, (1) 43-56.

Martino G, Bacigaluppi M(2011). Mechanism of action of somatic stem cell treatments: towards the concept of therapeutic plasticity. Cytotherapy vol. 13, (1) 6-7.

Dalla Libera D, Di Mitri D, Bergami A, Centonze D, Gasperini C, Grasso MG, Galgani S, Martinelli V et al.(2011). T regulatory cells are markers of disease activity in multiple sclerosis patients. PLoS One vol. 6, (6)

Esposito M, Ruffini F, Bergami A, Garzetti L, Borsellino G, Battistini L, Martino G, Furlan R(2010). IL-17- and IFN-γ-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity. J Immunol vol. 185, (12) 7467-7473.

Furlan R, Maiorino C, Gatta A, Ruffini F, Martino G(2010). Gene therapy of multiple sclerosis.

Pluchino S, Bacigaluppi M, Brini E, Butti E, Cossetti C, Cusimano M, Zanotti L, Martino G(2010). The neural stem cells. Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems,

Rossi S, De Chiara V, Furlan R, Musella A, Cavasinni F, Muzio L, Bernardi G, Martino G et al.(2010). Abnormal activity of the Na/Ca exchanger enhances glutamate transmission in experimental autoimmune encephalomyelitis. Brain Behav Immun vol. 24, (8) 1379-1385.

Bacigaluppi M, Pluchino S, Jametti LP, Kilic E, Kilic U, Salani G, Brambilla E, West MJ et al.(2010). Erratum: Delayed postischaemicneuroprotection following systemic neural stem cell transplantation involves multiple mechanisms (Brain (2009) 132:PART 8 (2239-2251) DOI: 10.1093/brain/awp174). Brain vol. 133, (11)

Centonze D, Muzio L, Rossi S, Furlan R, Bernardi G, Martino G(2010). The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis. Cell Death Differ vol. 17, (7) 1083-1091.

Pluchino S, Cusimano M, Bacigaluppi M, Martino G(2010). Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches. Arch Ital Biol vol. 148, (2) 173-183.

Martino G, Franklin RJM, Baron Van Evercooren A, Kerr DA, Stem Cells in Multiple Sclerosis (STEMS) Consensus Group(2010). Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat Rev Neurol vol. 6, (5) 247-255.

Melzi R, Antonioli B, Mercalli A, Battaglia M, Valle A, Pluchino S, Galli R, Sordi V et al.(2010). Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice. PLoS One vol. 5, (4)

Esposito M, Ruffini F, Bellone M, Gagliani N, Battaglia M, Martino G, Furlan R(2010). Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation. J Neuroimmunol vol. 220, (1-2) 52-63.

Piccolo G, Tavazzi E, Cavallaro T, Romani A, Scelsi R, Martino G(2010). Clinico-pathological findings in a patient with progressive cerebellar ataxia, autoimmune polyendocrine syndrome, hepatocellular carcinoma and anti-GAD autoantibodies. J Neurol Sci vol. 290, (1-2) 148-149.

Muzio L, Cavasinni F, Marinaro C, Bergamaschi A, Bergami A, Porcheri C, Cerri F, Dina G et al.(2010). Cxcl10 enhances blood cells migration in the sub-ventricular zone of mice affected by experimental autoimmune encephalomyelitis. Mol Cell Neurosci vol. 43, (3) 268-280.

Fazio R, Malosio ML, Lampasona V, De Feo D, Privitera D, Marnetto F, Centonze D, Ghezzi A et al.(2009). Antiacquaporin 4 antibodies detection by different techniques in neuromyelitis optica patients. Mult Scler vol. 15, (10) 1153-1163.

Rossi S, Furlan R, De Chiara V, Musella A, Lo Giudice T, Mataluni G, Cavasinni F, Cantarella C et al.(2009). Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis. Neurobiol Dis vol. 36, (1) 51-59.

Jametti PL, Bacigaluppi M, Pluchino S, Kilic E, Kilic U, Salani G, Brambilla E, Comi G et al. (2009). POST-ISCHEMIC DELAYED NEURAL STEM/PRECURSOR CELLS (NPCS) TRANSPLANTATION IMPROVES FUNCTIONAL OUTCOME THROUGHOUT MULTIPLE NEURO-GLIA INTERACTIONS. GLIA. vol. 57, S55-S55.

Pluchino S, Gritti A, Blezer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U et al.(2009). Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol vol. 66, (3) 343-354.

Martino G(2009). [Joy between conscience and (neuro)science]. Kos vol. 26, (273) 16-32.

Bacigaluppi M, Pluchino S, Peruzzotti-Jametti L, Kilic E, Kilic U, Salani G, Brambilla E, West MJ et al.(2009). Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain vol. 132, (Pt 8) 2239-2251.

Shechter R, London A, Varol C, Raposo C, Cusimano M, Yovel G, Rolls A, Mack M et al.(2009). Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med vol. 6, (7)

Pluchino S, Zanotti L, Brambilla E, Rovere-Querini P, Capobianco A, Alfaro-Cervello C, Salani G, Cossetti C et al.(2009). Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function. PLoS One vol. 4, (6)

Pluchino S, Zanotti L, Brini E, Ferrari S, Martino G(2009). Regeneration and repair in multiple sclerosis: the role of cell transplantation. Neurosci Lett vol. 456, (3) 101-106.

Brini E, Ruffini F, Bergami A, Brambilla E, Dati G, Greco B, Cirillo R, Proudfoot AEI et al.(2009). Administration of a monomeric CCL2 variant to EAE mice inhibits inflammatory cell recruitment and protects from demyelination and axonal loss. J Neuroimmunol vol. 209, (1-2) 33-39.

Centonze D, Muzio L, Rossi S, Cavasinni F, De Chiara V, Bergami A, Musella A, D'Amelio M et al.(2009). Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J Neurosci vol. 29, (11) 3442-3452.

Furlan R, Cuomo C, Martino G(2009). Animal models of multiple sclerosis. Methods Mol Biol vol. 549, 157-173.

Meloni F, Accapezzato D, Agresti C, Aloisi F, Ristori G, Salvetti M, Furlan R, Martino G et al.(2008). Dendritic cells loaded with apoptotic oligodendrocytes as a source of myelin T-cell epitopes in multiple sclerosis. Clin Immunol vol. 129, (2) 286-294.

Bacigaluppi M, Pluchino S, Jametti LP, Kilic E, Comi G, Hermann D, Martino G (2008). Neural stem/precursor cell (NPC) transplantation in mice with experimental cerebral ischemic stroke: A study on neurorestoration and neuroprotection. JOURNAL OF NEUROIMMUNOLOGY. vol. 203, 249-250.

Pluchino S, Muzio L, Imitola J, Deleidi M, Alfaro-Cervello C, Salani G, Porcheri C, Brambilla E et al.(2008). Persistent inflammation alters the function of the endogenous brain stem cell compartment. Brain vol. 131, (Pt 10) 2564-2578.

Gironi M, Martinelli-Boneschi F, Sacerdote P, Solaro C, Zaffaroni M, Cavarretta R, Moiola L, Bucello S et al.(2008). A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis. Mult Scler vol. 14, (8) 1076-1083.

Villoslada P, Moreno B, Melero I, Pablos JL, Martino G, Uccelli A, Montalban X, Avila J et al.(2008). Immunotherapy for neurological diseases. Clin Immunol vol. 128, (3) 294-305.

Teggi R, Piccioni LO, Martino G, Bellini C, Bussi M(2008). Stiff-person syndrome with acute recurrent peripheral vertigo: possible evidence of gamma aminobutyric acid as a neurotransmitter in the vestibular periphery. J Laryngol Otol vol. 122, (6) 636-638.

Butti E, Bergami A, Recchia A, Brambilla E, Del Carro U, Amadio S, Cattalini A, Esposito M et al.(2008). IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Gene Ther vol. 15, (7) 504-515.

Pluchino S, Martino G(2008). Neural stem cell-mediated immunomodulation: repairing the haemorrhagic brain. Brain vol. 131, (Pt 3) 604-605.

Martino G(2008). [To heal regenerating]. Kos vol. 25, (264) 41-51.

Bacigaluppi M, Pluchino S, Martino G, Kilic E, Hermann DM(2008). Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci vol. 265, (1-2) 73-77.

Pluchino S, Martino G(2008). The therapeutic plasticity of neural stem/precursor cells in multiple sclerosis. J Neurol Sci vol. 265, (1-2) 105-110.

Butti E, Bergami A, Recchia A, Brambilla E, Franciotta D, Cattalini A, Stornaiuolo A, Lachapelle F et al.(2008). Absence of an intrathecal immune reaction to a helper-dependent adenoviral vector delivered into the cerebrospinal fluid of non-human primates. Gene Ther vol. 15, (3) 233-238.

Muzio L, Martino G, Furlan R(2007). Multifaceted aspects of inflammation in multiple sclerosis: the role of microglia. J Neuroimmunol vol. 191, (1-2) 39-44.

Politi LS, Bacigaluppi M, Brambilla E, Cadioli M, Falini A, Comi G, Scotti G, Martino G et al.(2007). Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis. Stem Cells vol. 25, (10) 2583-2592.

Centonze D, Bari M, Rossi S, Prosperetti C, Furlan R, Fezza F, De Chiara V, Battistini L et al.(2007). The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. Brain vol. 130, (Pt 10) 2543-2553.

Martino G, Pluchino S(2007). Neural stem cells: guardians of the brain. Nat Cell Biol vol. 9, (9) 1031-1034.

Bacigaluppi M, Kilic E, Pluchino S, Spudich A, Deleidi M, Zanotti L, Bassetti CL, Comi GC et al. (2007). Postacute intravenous delivery of adult neural precursor (stem) cells promotes functional recovery after focal cerebral ischaemia in mice. JOURNAL OF NEUROLOGY. vol. 254, 143-143.

Pluchino S, Zanotti L, Martino G(2007). Rationale for the use of neural stem/precursor cells in immunemediated demyelinating disorders. Journal of Neurology vol. 254, (1 SUPPL.)

Furlan R, Bergami A, Brambilla E, Butti E, De Simoni MG, Campagnoli M, Marconi P, Comi G et al.(2007). HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG(35-55)-induced experimental autoimmune encephalomyelitis in C57BL/6 mice. Gene Ther vol. 14, (1) 93-98.

Ziv Y, Avidan H, Pluchino S, Martino G, Schwartz M(2006). Erratum: Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury (Proceedings of the National Academy (2006) 103, (13174-13179) DOI: 10.1073/pnas.0603747103). Proceedings of the National Academy of Sciences of the United States of America vol. 103, (48)

Politi LS, Pluchino S, Bacigaluppi M, Brambilla E, Cadioli M, Cattalini A, Falini A, Anzalone N et al. (2006). In vivo magnetic resonance imaging of intravenously injected neural stem cells in a mouse model of multiple sclerosis. Neuroradiology Journal. vol. 19, 633-636.

Ziv Y, Avidan H, Pluchino S, Martino G, Schwartz M(2006). Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc Natl Acad Sci U S A vol. 103, (35) 13174-13179.

Martino G, Pluchino S(2006). The therapeutic potential of neural stem cells. Nat Rev Neurosci vol. 7, (5) 395-406.

Comi G, Martino G (2006). MS treatment: new perspectives. Clin Neurol Neurosurg. vol. 108, 339-345.

Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M(2006). Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci vol. 31, (1) 149-160.

Furlan R, Rovaris M, Martinelli Boneschi F, Khademi M, Bergami A, Gironi M, Deleidi M, Agosta F et al.(2005). Immunological patterns identifying disease course and evolution in multiple sclerosis patients. J Neuroimmunol vol. 165, (1-2) 192-200.

Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A et al.(2005). Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature vol. 436, (7048) 266-271.

Pluchino S, Martino G (2005). The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disorders. J Neurol Sci. vol. 233, 117-119.

Mancardi GL, Murialdo A, Rossi P, Gualandi F, Martino G, Marmont A, Ciceri F, Schenone A et al.(2005). Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis. Mult Scler vol. 11, (3) 367-371.

Martino G(2005). Cellular therapy in multiple sclerosis: where we are and where we are going. Neurol Sci vol. 26 Suppl 1,

Pedotti R, Aloisi F, Martino G, Furlan R (2005). Highlights from the Seventh International Congress of the International Society of Neuroimmunology. J Neuroimmunol. vol. 162, 5-11.

Pluchino S, Zanotti L, Deleidi M, Martino G (2005). Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Brain Res Rev. vol. 48, 211-219.

Lemoli RM, Bertolini F, Cancedda R, De Luca M, Del Santo A, Ferrari G, Ferrari S, Martino G et al.(2005). Stem cell plasticity: time for a reappraisal?. Haematologica vol. 90, (3) 360-381.

Pluchino S, Bacigaluppi M, Bucello S, Butti E, Deleidi M, Zanotti L, Martino G, Furlan R(2005). Gene and stem cell therapy for autoimmune demyelination. Ernst Schering Res Found Workshop (53) 133-146.

Furlan R, Butti E, Pluchino S, Martino G(2004). Gene therapy for autoimmune diseases. Curr Opin Mol Ther vol. 6, (5) 525-536.

Lampasona V, Franciotta D, Furlan R, Zanaboni S, Fazio R, Bonifacio E, Comi G, Martino G(2004). Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects. Neurology vol. 62, (11) 2092-2094.

Pluchino S, Furlan R, Martino G(2004). Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studies. Curr Opin Neurol vol. 17, (3) 247-255.

Martino G(2004). How the brain repairs itself: new therapeutic strategies in inflammatory and degenerative CNS disorders. Lancet Neurol vol. 3, (6) 372-378.

Furlan R, Kurne A, Bergami A, Brambilla E, Maucci R, Gasparini L, Butti E, Comi G et al.(2004). A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis. J Neuroimmunol vol. 150, (1-2) 10-19.

Furlan R, Salani G, Bergami A, Martino G(2004). Detection of TNF and TNF receptor mRNA in cells and tissues. Methods Mol Med vol. 98, 59-72.

Furlan R, Villa P, Senaldi G, Martino G(2004). TNFalpha in experimental diseases of the CNS. Methods Mol Med vol. 98, 171-190.

Pluchino S, Zanotti L, Martino G(2003). Antibodies and myelination: facts and misacts. Neurol Sci vol. 24 Suppl 4, S231-S233.

Martino G (2003). Perspectives in gene therapy for MS. Int MS J. vol. 10, 84-88.

Furlan R, Bergami A, Cantarella D, Brambilla E, Taniguchi M, Dellabona P, Casorati G, Martino G(2003). Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma. Eur J Immunol vol. 33, (7) 1830-1838.

Lampasona V, Rio J, Franciotta D, Furlan R, Avolio C, Fazio R, Lavolpe V, Vincent A et al.(2003). Serial immunoprecipitation assays for interferon--(IFN)-beta antibodies in multiple sclerosis patients. Eur Cytokine Netw vol. 14, (3) 154-157.

Furlan R, Pluchino S, Martino G(2003). The therapeutic use of gene therapy in inflammatory demyelinating diseases of the central nervous system. Curr Opin Neurol vol. 16, (3) 385-392.

Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U et al.(2003). Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature vol. 422, (6933) 688-694.

Furlan R, Brambilla E, Sanvito F, Roccatagliata L, Olivieri S, Bergami A, Pluchino S, Uccelli A et al.(2003). Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. Brain vol. 126, (Pt 2) 285-291.

Furlan R, Pluchino S, Marconi PC, Martino G(2003). Cytokine gene delivery into the central nervous system using intrathecally injected nonreplicative viral vectors. Methods Mol Biol vol. 215, 279-289.

Furlan R, Pluchino S, Martino G(2003). Gene therapy-mediated modulation of immune processes in the central nervous system. Curr Pharm Des vol. 9, (24) 2002-2008.

Martino G, Adorini L, Rieckmann P, Hillert J, Kallmann B, Comi G, Filippi M(2002). Inflammation in multiple sclerosis: the good, the bad, and the complex. Lancet Neurol vol. 1, (8) 499-509.

Franciotta D, Martino G, Zardini E, Furlan R, Bergamaschi R, Gironi M, Bergami A, Angelini G et al.(2002). Caspase-1 levels in biological fluids from patients with multiple sclerosis and from patients with other neurological and non-neurological diseases. Eur Cytokine Netw vol. 13, (1) 99-103.

Pizzigallo E, Toccaceli F, Vecchiet J, Di Girolamo A, Sereno S, Koch M, Capurso L, Lagiii V et al.(2001). Re-treatment of patients with chronic hepatitis C in clinical practice: Results of a multicenter retrospective survey. Giornale Italiano di Malattie Infettive vol. 7, (4) 206-215.

Martino G, Furlan R, Comi G, Adorini L(2001). The ependymal route to the CNS: an emerging gene-therapy approach for MS. Trends Immunol vol. 22, (9) 483-490.

Ruffini F, Furlan R, Poliani PL, Brambilla E, Marconi PC, Bergami A, Desina G, Glorioso JC et al.(2001). Fibroblast growth factor-II gene therapy reverts the clinical course and the pathological signs of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice. Gene Ther vol. 8, (16) 1207-1213.

Furlan R, Brambilla E, Ruffini F, Poliani PL, Bergami A, Marconi PC, Franciotta DM, Penna G et al.(2001). Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes. J Immunol vol. 167, (3) 1821-1829.

Poliani PL, Brok H, Furlan R, Ruffini F, Bergami A, Desina G, Marconi PC, Rovaris M et al.(2001). Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis. Hum Gene Ther vol. 12, (8) 905-920.

Franciotta D, Martino G, Zardini E, Furlan R, Bergamaschi R, Andreoni L, Cosi V(2001). Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies. J Neuroimmunol vol. 115, (1-2) 192-198.

Furlan R, Poliani PL, Marconi PC, Bergami A, Ruffini F, Adorini L, Glorioso JC, Comi G et al.(2001). Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice. Gene Ther vol. 8, (1) 13-19.

Furlan R, Bergami A, Lang R, Brambilla E, Franciotta D, Martinelli V, Comi G, Panina P et al.(2000). Interferon-beta treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-gamma and interleukin-4. J Neuroimmunol vol. 111, (1-2) 86-92.

Martino G(2000). Letter to the Editor-in-Chief. Journal of Neuroimmunology vol. 109, (2) 64-65.

Martino G, Furlan R, Brambilla E, Bergami A, Ruffini F, Gironi M, Poliani PL, Grimaldi LM et al.(2000). Cytokines and immunity in multiple sclerosis: the dual signal hypothesis. J Neuroimmunol vol. 109, (1) 3-9.

Martino G, Poliani PL, Furlan R, Marconi P, Glorioso JC, Adorini L, Comi G (2000). Cytokine therapy in immune-mediated demyelinating diseases of the central nervous system: a novel gene therapy approach. J Neuroimmunol. vol. 107, 184-190.

Martino G, Poliani PL, Marconi PC, Comi G, Furlan R(2000). Cytokine gene therapy of autoimmune demyelination revisited using herpes simplex virus type-1-derived vectors. Gene Ther vol. 7, (13) 1087-1093.

Comi G, Martino G (2000). [Rationale for an early treatment of multiple sclerosis]. Rev Neurol. vol. 30, 1265-1268.

Martino G, Furlan R, Poliani PL (2000). [The pathogenic role of inflammation in multiple sclerosis]. Rev Neurol. vol. 30, 1213-1217.

Comi G, Kappos L, Clanet M, Ebers G, Fassas A, Fazekas F, Filippi M, Hartung HP et al.(2000). Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. BMT-MS Study Group. J Neurol vol. 247, (5) 376-382.

Mattner F, Smiroldo S, Galbiati F, Muller M, Di Lucia P, Poliani PL, Martino G, Panina-Bordignon P et al.(2000). Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3). Eur J Immunol vol. 30, (2) 498-508.

Gironi M, Bergami A, Brambilla E, Ruffini F, Furlan R, Comi G, Martino G(2000). Immunological markers in multiple sclerosis. Neurol Sci vol. 21, (4 Suppl 2) S871-S875.

Sipe JC, Filippi M, Martino G, Furlan R, Rocca MA, Rovaris M, Bergami A, Zyroff J et al.(1999). Method for intracellular magnetic labeling of human mononuclear cells using approved iron contrast agents. Magn Reson Imaging vol. 17, (10) 1521-1523.

Furlan R, Filippi M, Bergami A, Rocca MA, Martinelli V, Poliani PL, Grimaldi LM, Desina G et al.(1999). Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study. J Neurol Neurosurg Psychiatry vol. 67, (6) 785-788.

Del Maschio A, De Luigi A, Martin-Padura I, Brockhaus M, Bartfai T, Fruscella P, Adorini L, Martino G et al.(1999). Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM). J Exp Med vol. 190, (9) 1351-1356.

Furlan R, Martino G, Galbiati F, Poliani PL, Smiroldo S, Bergami A, Desina G, Comi G et al.(1999). Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol vol. 163, (5) 2403-2409.

Franciotta D, Bergamaschi R, Martino G, Zardini E, Desina G, Cosi V(1999). Tumor necrosis factor-alpha and its soluble receptors in plasma and cerebrospinal fluid of multiple sclerosis patients treated with methylprednisolone. Eur Cytokine Netw vol. 10, (3) 431-436.

Sciacca FL, Ferri C, Vandenbroeck K, Veglia F, Gobbi C, Martinelli F, Franciotta D, Zaffaroni M et al.(1999). Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients. Neurology vol. 52, (9) 1896-1898.

Kieseier BC, Storch MK, Archelos JJ, Martino G, Hartung HP(1999). Effector pathways in immune mediated central nervous system demyelination. Curr Opin Neurol vol. 12, (3) 323-336.

Martino G, Hartung HP(1999). Immunopathogenesis of multiple sclerosis: the role of T cells. Curr Opin Neurol vol. 12, (3) 309-321.

Franciotta D, Martino G, Brambilla E, Zardini E, Locatelli V, Bergami A, Tinelli C, Desina G et al.(1999). TE671 cell-based ELISA for anti-acetylcholine receptor antibody determination in myasthenia gravis. Clin Chem vol. 45, (3) 400-405.

Furlan R, Poliani PL, Galbiati F, Bergami A, Grimaldi LM, Comi G, Adorini L, Martino G(1998). Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination. Hum Gene Ther vol. 9, (17) 2605-2617.

Comi G, Martinelli V, Martino G (1998). Early treatment of multiple sclerosis. European Journal of Neurology. vol. 5,

Moiola L, Galbiati F, Martino G, Amadio S, Brambilla E, Comi G, Vincent A, Grimaldi LM et al.(1998). IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody-mediated disease. Eur J Immunol vol. 28, (8) 2487-2497.

Martino G, Furlan R, Galbiati F, Poliani PL, Bergami A, Grimaldi LM, Adorini L, Comi G(1998). A gene therapy approach to treat demyelinating diseases using non-replicative herpetic vectors engineered to produce cytokines. Mult Scler vol. 4, (3) 222-227.

Filippi M, Rocca MA, Martino G, Horsfield MA, Comi G(1998). Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis. Ann Neurol vol. 43, (6) 809-814.

Martino G, Grohovaz F, Brambilla E, Codazzi F, Consiglio A, Clementi E, Filippi M, Comi G et al.(1998). Proinflammatory cytokines regulate antigen-independent T-cell activation by two separate calcium-signaling pathways in multiple sclerosis patients. Ann Neurol vol. 43, (3) 340-349.

Martino G, Grohovaz F, Brambilla E, Clementi E(1997). Antigen-indipendent peripheral immune. Activation precedes clinical and mri evidence of disease activity in MS. Italian Journal of Neurological Sciences vol. 18, (4)

Vandenbroeck K, Consiglio A, Marrosu M, Franciotta D, Zaffaroni M, Martino G, Grimaldi LME(1997). Occurence and clinical relevance of an interleukin-4 gene polymorphism im patients with multiple sclerosis. Italian Journal of Neurological Sciences vol. 18, (4)

Sciacca FL, Vandenbroeck K, Marrosu M, Franoiotta D, Zaffaroni M, Martino G, Grimaldi LME(1997). Soluble interleukin-1 receptor antagonist intron 2 polymorphism: Functional role and relevance in multiple sclerosis. Italian Journal of Neurological Sciences vol. 18, (4)

Martino G, Consiglio A, Corti A, Sciacca FL, Grimaldi LME(1997). Tumor necrosis factor O and its receptors in multiple sclerosis. Italian Journal of Neurological Sciences vol. 18, (4)

Martino G, Consiglio A, Franciotta DM, Corti A, Filippi M, Vandenbroeck K, Sciacca FL, Comi G et al.(1997). Tumor necrosis factor alpha and its receptors in relapsing-remitting multiple sclerosis. J Neurol Sci vol. 152, (1) 51-61.

Martino G, Filippi M, Martinelli V, Brambilla E, Gobbi C, Comi G, Grimaldi LM(1997). Interferon-gamma induced increases in intracellular calcium in T lymphocytes from patients with multiple sclerosis precede clinical exacerbations and detection of active lesions on MRI. J Neurol Neurosurg Psychiatry vol. 63, (3) 339-345.

Vandenbroeck K, Martino G, Marrosu M, Consiglio A, Zaffaroni M, Vaccargiu S, Franciotta D, Ruggeri M et al.(1997). Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis. J Neuroimmunol vol. 76, (1-2) 189-192.

Filippi M, Campi A, Martino G, Colombo B, Comi G(1997). A magnetization transfer study of white matter in siblings of multiple sclerosis patients. J Neurol Sci vol. 147, (2) 151-153.

Vincent A, Grimaldi LM, Martino G, Davenport C, Todd I(1997). Antibodies to 125I-glutamic acid decarboxylase in patients with stiff man syndrome. J Neurol Neurosurg Psychiatry vol. 62, (4) 395-397.

Martino G(1997). The pathogenetic role of interferon-γ in multiple sclerosis. Interferon Therapy of Multiple Sclerosis,

Martino G, Brambilla E, Filippi M, Martinelli V, Colombo B, Rodegher M, Comi G, Grimaldi LM(1996). Interferon-gamma activated calcium influx in peripheral blood lymphocytes from patients with primary and secondary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry vol. 61, (5) 515-517.

Perretti A, Santoro L, Lanzillo B, Filla A, De Michele G, Barbieri F, Martino G, Ragno M et al.(1996). Autosomal dominant cerebellar ataxia type I: multimodal electrophysiological study and comparison between SCA1 and SCA2 patients. J Neurol Sci vol. 142, (1-2) 45-53.

Cortese I, Tafi R, Grimaldi LM, Martino G, Nicosia A, Cortese R(1996). Identification of peptides specific for cerebrospinal fluid antibodies in multiple sclerosis by using phage libraries. Proc Natl Acad Sci U S A vol. 93, (20) 11063-11067.

Martino G, Grimaldi LM, Bazzigaluppi E, Passini N, Sinigaglia F, Rogge L(1996). The insulin-dependent diabetes mellitus-associated ICA 105 autoantigen in stiff-man syndrome patients. J Neuroimmunol vol. 69, (1-2) 129-134.

Furlan R, Salazar-Grueso EF, Martino G, Roos RP, Brambilla E, Castellano M, Cao J, Lillo F et al.(1996). Human T-cell lymphotropic virus type-I infection in the severe combined immunodeficiency mouse. J Med Virol vol. 49, (2) 77-82.

Martino G, Filippi M, Martinelli V, Brambilla E, Comi G, Grimaldi LM(1996). Clinical and radiologic correlates of a novel T lymphocyte gamma-interferon-activated Ca2+ influx in patients with relapsing-remitting multiple sclerosis. Neurology vol. 46, (5) 1416-1421.

Vandenbroeck K, Consiglio A, Martino G, Grimaldi LM(1996). Improved conditions for the analysis of large variable number of tandemly repeated (VNTR) unit polymorphisms. Electrophoresis vol. 17, (4) 678-680.

Martino G, Moiola L, Brambilla E, Clementi E, Comi G, Grimaldi LM(1995). Interferon-gamma induces T lymphocyte proliferation in multiple sclerosis via a Ca(2+)-dependent mechanism. J Neuroimmunol vol. 62, (2) 169-176.

Filippi M, Martino G, Mammi S, Campi A, Comi G, Grimaldi LM(1995). Does hemispheric dominance influence brain lesion distribution in multiple sclerosis?. J Neurol Neurosurg Psychiatry vol. 58, (6) 748-749.

Selmaj KW, Raine CS(1995). Experimental autoimmune encephalomyelitis: immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors. Neurology vol. 45, (6 Suppl 6) S44-S49.

Grimaldi LM, Martino G(1995). Effect of interferon gamma on T lymphocytes from patients with multiple sclerosis. Mult Scler vol. 1 Suppl 1, S38-S43.

Martino G, Furlan R, Brambilla E, Castellano M, Terreni MR, Comi G, Grimaldi LM(1994). Absence of central nervous system pathology in severe combined immunodeficiency mice intraperitoneally injected with peripheral blood lymphocytes from multiple sclerosis patients. J Neuroimmunol vol. 55, (2) 213-217.

Furlan R, Salazar-Grueso EF, Martino G, Lillo F, Kotulski M, Brambilla E, Castellano M, Terreni MR et al.(1994). HTLV-I hu-SCID mouse in the study of HTLV-I neurotropism. Ann N Y Acad Sci vol. 724, 422-425.

Clementi E, Martino G, Grimaldi LM, Brambilla E, Meldolesi J(1994). Intracellular Ca2+ stores of T lymphocytes: changes induced by in vitro and in vivo activation. Eur J Immunol vol. 24, (6) 1365-1371.

Martino G, Clementi E, Brambilla E, Moiola L, Comi G, Meldolesi J, Grimaldi LM(1994). Gamma interferon activates a previously undescribed Ca2+ influx in T lymphocytes from patients with multiple sclerosis. Proc Natl Acad Sci U S A vol. 91, (11) 4825-4829.

Martino G, Twaddle G, Brambilla E, Grimaldi LM(1994). Detection of anti-acetylcholine receptor antibody by an ELISA using human receptor from a rhabdomyosarcoma cell line. Acta Neurol Scand vol. 89, (1) 18-22.

Rossini PM, Traversa R, Boccasena P, Martino G, Passarelli F, Pacifici L, Bernardi G, Stanzione P(1993). Parkinson's disease and somatosensory evoked potentials: apomorphine-induced transient potentiation of frontal components. Neurology vol. 43, (12) 2495-2500.

Grimaldi LM, Martino G, Braghi S, Quattrini A, Furlan R, Bosi E, Comi G(1993). Heterogeneity of autoantibodies in stiff-man syndrome. Ann Neurol vol. 34, (1) 57-64.

Martino G, DuPont BL, Wollmann RL, Bongioanni P, Anastasi J, Quintans J, Arnason BG, Grimaldi LM(1993). The human-severe combined immunodeficiency myasthenic mouse model: a new approach for the study of myasthenia gravis. Ann Neurol vol. 34, (1) 48-56.

Martino G, Grimaldi LM, Wollmann RL, Bongioanni P, Quintans J, Arnason BG(1993). The hu-SCID myasthenic mouse. A new tool for the investigation of seronegative myasthenia gravis. Ann N Y Acad Sci vol. 681, 303-305.

Grimaldi LM, Luzi L, Martino GV, Furlan R, Nemni R, Antonelli A, Canal N, Pozza G(1993). Bilateral eighth cranial nerve neuropathy in human immunodeficiency virus infection. J Neurol vol. 240, (6) 363-366.

Martino G, Servalli C, Filippi M, Buscemi M, Martinelli V, Furlan R, Comi G, Grimaldi LM(1993). Absence of oligoclonally restricted immunoglobulins in tears from multiple sclerosis patients. J Neuroimmunol vol. 44, (2) 149-155.

Martino G, Anastasi J, Feng J, Mc Shan C, DeGroot L, Quintans J, Grimaldi LM(1993). The fate of human peripheral blood lymphocytes after transplantation into SCID mice. Eur J Immunol vol. 23, (5) 1023-1028.

Grimaldi LME, Martino GV, Franciotta DM, Brustia R, Castagna A, Pristerá R, Lazzarin A(1992). Reply. Annals of Neurology vol. 31, (6) 688-689.

Martino GV, Tappaz ML, Braghi S, Dozio N, Canal N, Pozza G, Bottazzo GF, Grimaldi LM et al.(1991). Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: relation to insulin-dependent diabetes mellitus and islet cell antibodies. J Autoimmun vol. 4, (6) 915-923.

Martino G, Olsson T, Fredrikson S, Hojeberg B, Kostulas V, Grimaldi LM, Link H(1991). Cells producing antibodies specific for myelin basic protein region 70-89 are predominant in cerebrospinal fluid from patients with multiple sclerosis. Eur J Immunol vol. 21, (12) 2971-2976.

Martino G, Traversa R, De Simone R, Rossini PM(1991). [Neurological complications of schistosomiasis]. Clin Ter vol. 138, (5-6) 233-238.

Grimaldi LM, Castagna A, Maimone D, Martino GV, Dolci A, Pristera R, Lazzarin A, Roos RP(1991). Kappa light chain predominance in serum and cerebrospinal fluid from human immunodeficiency virus type 1 (HIV-1)-infected patients. J Neuroimmunol vol. 32, (3) 259-268.

Grimaldi LM, Martino GV(1991). CSF oligoclonal banding pattern changes in a long-surviving SSPE patient treated with alpha-IFN. Ital J Neurol Sci vol. 12, (2) 187-191.

Grimaldi LM, Martino GV, Franciotta DM, Brustia R, Castagna A, Pristerà R, Lazzarin A(1991). Elevated alpha-tumor necrosis factor levels in spinal fluid from HIV-1-infected patients with central nervous system involvement. Ann Neurol vol. 29, (1) 21-25.

Martino G, Grimaldi LM, Moiola L, Filippi M, Martinelli V, Comi G, Canal N(1990). Discontinuous distribution of IgG oligoclonal bands in cerebrospinal fluid from multiple sclerosis patients. J Neuroimmunol vol. 30, (2-3) 129-134.

Martino GV, Grimaldi LM, Franciotta DM, Piccolo G, Brustia R, Minali L, Melzi d'Eril GV(1990). Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis. Acta Neurol Scand vol. 82, (6) 364-367.

Piccolo G, Martino G, Moglia A, Arrigo A, Cosi V(1990). Autoimmune myastenia gravis with thymoma following the spontaneous remission of stiff-man syndrome. Ital J Neurol Sci vol. 11, (2) 177-180.

Martino GV, Grimaldi LM, Moiola L, Cichero P, Ieri R, Bonini PA(1990). Antibody against EBV in CSF from HIV-1 and HTLV-I infected patients. Acta Neurol (Napoli) vol. 12, (1) 68-70.

Martino GV, Grimaldi LM, Moiola L, Castagna A, Novati R, D'Armini-Monforte A, Massironi E, Marchisio P et al.(1990). Immunological study in newborns at risk for HIV-1 infection. Acta Neurol (Napoli) vol. 12, (1) 71-74.

Rossini PM, Martino G, Traversa R(1990). Methodological and physiological aspects of motor evoked potentials. Rivista Italiana di Elettroencefalografia e Neurofisiologia Clinica vol. 13, (2) 69-81.

Franciotta DM, Grimaldi LM, Martino GV, Piccolo G, Bergamaschi R, Citterio A, Melzi d'Eril GV(1989). Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis. Ann Neurol vol. 26, (6) 787-789.

Franciotta DM, Martino GV, Bergamaschi R, Piccolo G, Citterio A, Melzi d'Eril GV, Cosi V(1988). Failure to detect antibodies to HTLV-I in serum and CSF of 50 multiple sclerosis patients. Acta Neurol (Napoli) vol. 10, (6) 331-334.

Piccolo G, Martino G(1988). Ocular palsy preceding chronic relapsing idiopathic polyneuropathy. Poor response to plasma exchange. Ital J Neurol Sci vol. 9, (4) 383-384.

Di Dario M, Colombo E, Govi C, De Feo D, Messina MJ, Romeo M, Sangalli F, Moiola L et al.(1952). Myeloid cells as target of fingolimod action in multiple sclerosis. Neurology vol. 2, (6)