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Publications:  Dr Ewan Main

Perez-Riba A, Komives E, Main E, Itzhaki L(2019). Decoupling a tandem-repeat protein: impact of multiple loop insertions on a modular scaffold. Scientific Reports
Wright JN, Wong WL, Harvey JA, Garnett JA, Itzhaki LS, Main ERG(2019). Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins. Structure vol. 27, (5) 776-784.e4.
Perez-Riba A, Lowe A, MAIN E, Itzhaki L(2018). Context-dependent energetics of loop extensions in a family of tandem-repeat proteins. Biophysical Journal
Harvey JA, Itzhaki LS, Main ERG(2018). Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation. ACS Synth Biol vol. 7, (4) 1067-1074.
Lowe AR, Perez-Riba A, Itzhaki LS, Main ERG(2018). PyFolding: Open-Source Graphing, Simulation, and Analysis of the Biophysical Properties of Proteins. Biophys J vol. 114, (3) 516-521.
Perez-Riba A, Lowe A, Main E, Komives E, Itzhaki L (2017). Entropically-Challenged Tandem-repeat Proteins: Breakdown of Nearest-Neighbour Cooperativity. PROTEIN SCIENCE. vol. 26, 108-108.
Millership C, Phillips JJ, Main ERG(2016). Ising Model Reprogramming of a Repeat Protein's Equilibrium Unfolding Pathway. J Mol Biol vol. 428, (9 Pt A) 1804-1817.
Perez-Riba A, Main ER, Itzhaki LS (2016). The Effect of Loop Insertions on the Folding of Tandem-Repeat Proteins. BIOPHYSICAL JOURNAL. vol. 110, 181A-181A.
Rowling PJE, Sivertsson EM, Perez-Riba A, Main ERG, Itzhaki LS(2015). Dissecting and reprogramming the folding and assembly of tandem-repeat proteins. Biochemical Society Transactions vol. 43, 881-888.
Main ERG, Phillips JJ, Millership C(2013). Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks. Biochem Soc Trans vol. 41, (5) 1152-1158.
Singh SK, Boyle AL, Main ERG(2013). LcrH, a class II chaperone from the type three secretion system, has a highly flexible native structure. J Biol Chem vol. 288, (6) 4048-4055.
Phillips JJ, Millership C, Main ERG(2012). Fibrous nanostructures from the self-assembly of designed repeat protein modules. Angew Chem Int Ed Engl vol. 51, (52) 13132-13135.
Phillips JJ, Javadi Y, Millership C, Main ERG(2012). Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors. Protein Sci vol. 21, (3) 327-338.
Mahendrarajah K, Dalby PA, Wilkinson B, Jackson SE, Main ERG(2011). A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding. Anal Biochem vol. 411, (1) 155-157.
Boyd LK, Mercer B, Thompson D, Main E, Watts FZ(2010). Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60. PLoS One vol. 5, (9)
Gaudet M, Remtulla N, Jackson SE, Main ERG, Bracewell DG, Aeppli G, Dalby PA(2010). Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale. PROTEIN SCI vol. 19, (8) 1544-1554.
Javadi Y, Main ERG(2009). Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins. P NATL ACAD SCI USA vol. 106, (41) 17383-17388.
Main ERG, Lowe AR, Mochrie SGJ, Jackson SE, Regan L(2005). A recurring theme in protein engineering: the design, stability and folding of repeat proteins. CURR OPIN STRUC BIOL vol. 15, (4) 464-471.
Kajander T, Cortajarena AL, Main ERG, Mochrie SGJ, Regan L(2005). A new folding paradigm for repeat proteins. J AM CHEM SOC vol. 127, (29) 10188-10190.
Main ERG, Stott K, Jackson SE, Regan L(2005). Local and long-range stability in tandemly arrayed tetratricopeptide repeats. P NATL ACAD SCI USA vol. 102, (16) 5721-5726.
Maxwell KL, Wildes D, Zarrine-Afsar A, de los Rios MA, Brown AG, Friel CT, Hedberg L, Horng JC et al.(2005). Protein folding: Defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. PROTEIN SCI vol. 14, (3) 602-616.
Main ERG, Jackson SE, Regan L(2003). The folding and design of repeat proteins: reaching a consensus. CURR OPIN STRUC BIOL vol. 13, (4) 482-489.
Main ERG, Xiong Y, Cocco MJ, D'Andrea L, Regan L(2003). Design of stable alpha-helical arrays from an idealized TPR motif. STRUCTURE vol. 11, (5) 497-508.
Main ERG, Fulton KF, Daggett V, Jackson SE(2001). A comparison of experimental and computational methods for mapping the interactions present in the transition state for folding of FKBP12. J BIOL PHYS vol. 27, (2) 99-117.
Main ERG, Jackson SE(1999). Does trifluoroethanol affect folding pathways and can it be used as a probe of structure in transition states?. NAT STRUCT BIOL vol. 6, (9) 831-835.
Main ERG, Fulton KF, Jackson SE(1999). Folding pathway of FKBP12 and characterisation of the transition state. J MOL BIOL vol. 291, (2) 429-444.
Fulton KF, Main ERG, Daggett V, Jackson SE(1999). Mapping the interactions present in the transition state for unfolding/folding of FKBP12. J MOL BIOL vol. 291, (2) 445-461.
Main ERG, Fulton KF, Jackson SE(1998). Context-dependent nature of destabilizing mutations on the stability of FKBP12. BIOCHEMISTRY-US vol. 37, (17) 6145-6153.
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