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Publications:  Dr John Connelly

Di Cio S, Iskratsch T, Connelly JT, Gautrot JE(2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Biomaterials vol. 232,
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R et al.(2019). Evidence for the desmosomal cadherin desmoglein-3 in regulating YAP and Phospho-YAP in keratinocyte responses to mechanical forces. International Journal of Molecular Sciences vol. 20, (24)
Theocharidis G, Connelly JT(2019). Minor collagens of the skin with not so minor functions. J Anat vol. 235, (2) 418-429.
Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT(2019). High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform. Advanced Biosystems1900011-1900011.
Ghetti M, Topouzi H, Theocharidis G, Papa V, Williams G, Bondioli E, Cenacchi G, Connelly JT et al.(2018). Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic. Br J Dermatol vol. 179, (2) 381-393.
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT(2018). Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling. Journal of Cell Science vol. 131, (10)
Li D, Sharili AS, Connelly J, Gautrot JE(2018). Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors. Biomacromolecules
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.(2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov
Kanapathy M, Hachach-Haram N, Bystrzonowski N, Connelly JT, O'Toole EA, Becker DL, Mosahebi A, Richards T(2017). Epidermal grafting for wound healing: a review on the harvesting systems, the ultrastructure of the graft and the mechanism of wound healing. Int Wound J vol. 14, (1) 16-23.
GAUTROT JEE, Di Cio S, Boggild T, Connelly J, Sutherland DS(2016). Differential Integrin Expression Regulates Cell Sensing of the Matrix Nanoscale Geometry. Acta Biomaterialia
Sharili AS, Kenny FN, Vartiainen MK, Connelly JT(2016). Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes. Sci Rep vol. 6, 33893-33893.
Kao AP, Connelly JT, Barber AH(2016). 3D nanomechanical evaluations of dermal structures in skin. Journal of the mechanical behavior of biomedical materials vol. 57, 14-23.
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT(2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136, (1) 74-83.
Almeida FV, Walko G, McMillan JR, McGrath JA, Wiche G, Barber AH, Connelly JT(2015). The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes. J Cell Sci vol. 128, (24) 4475-4486.
Kenny FN, Connelly JT(2015). Integrin-mediated adhesion and mechano-sensing in cutaneous wound healing. Cell and Tissue Research vol. 360, (3) 571-582.
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM(2015). Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1r onto the primary cilium associated with cilia elongation. Stem Cells vol. 33, (6) 1952-1961.
Costa P, Gautrot JE, Connelly JT(2014). Directing cell migration using micropatterned and dynamically adhesive polymer brushes. Acta Biomater vol. 10, (6) 2415-2422.
Sharili AS, Connelly JT(2014). Nucleocytoplasmic shuttling: a common theme in mechanotransduction. Biochem Soc Trans vol. 42, (3) 645-649.
McMurray RJ, Wann AKT, Thompson CL, Connelly JT, Knight MM(2013). Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. Sci Rep vol. 3,
Tan DW, Jensen KB, Trotter MW, Connelly JT, Broad S, Watt FM(2013). Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development vol. 140, (7) 1433-1444.
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP(2013). Super-resolution imaging strategies for cell biologists using a spinning disk microscope. PLoS One vol. 8, (10)
Costa P, Almeida FVM, Connelly JT(2012). Biophysical signals controlling cell fate decisions: how do stem cells really feel?. Int J Biochem Cell Biol vol. 44, (12) 2233-2237.
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.(2012). Extracellular-matrix tethering regulates stem-cell fate. Nat Mater vol. 11, (7) 642-649.
Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW-M, Watt FM(2012). Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo. J Invest Dermatol vol. 132, (4) 1084-1093.
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.(2012). Erratum: Extracellular-matrix tethering regulates stem-cell fate (Nature Materials (2012) 11 (642-649)). Nature Materials vol. 11, (8)
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.(2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials vol. 11, (7) 642-649.
Connelly JT(2012). Terminal differentiation of human epidermal stem cells on micro-patterned substrates. Methods Mol Biol vol. 916, 15-22.
Connelly JT, Petrie TA, García AJ, Levenston ME(2011). Fibronectin- and collagen-mimetic ligands regulate bone marrow stromal cell chondrogenesis in three-dimensional hydrogels. Eur Cell Mater vol. 22, 168-176.
Connelly JT, Mishra A, Gautrot JE, Watt FM(2011). Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One vol. 6, (11)
Connelly JT, Gautrot JE, Trappmann B, Tan DW-M, Donati G, Huck WTS, Watt FM(2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol vol. 12, (7) 711-718.
Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM, Huck WTS(2010). Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials vol. 31, (18) 5030-5041.
Connelly JT, Vanderploeg EJ, Mouw JK, Wilson CG, Levenston ME(2010). Tensile loading modulates bone marrow stromal cell differentiation and the development of engineered fibrocartilage constructs. Tissue Eng Part A vol. 16, (6) 1913-1923.
Connelly JT, García AJ, Levenston ME(2008). Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis. J Cell Physiol vol. 217, (1) 145-154.
Connelly JT, Wilson CG, Levenston ME(2008). Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs. Osteoarthritis Cartilage vol. 16, (9) 1092-1100.
Mouw JK, Connelly JT, Wilson CG, Michael KE, Levenston ME(2007). Dynamic compression regulates the expression and synthesis of chondrocyte-specific matrix molecules in bone marrow stromal cells. Stem Cells vol. 25, (3) 655-663.
Connelly JT, García AJ, Levenston ME(2007). Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels. Biomaterials vol. 28, (6) 1071-1083.
Connelly JT, Vanderploeg EJ, Levenston ME(2004). The influence of cyclic tension amplitude on chondrocyte matrix synthesis: experimental and finite element analyses. Biorheology vol. 41, (3-4) 377-387.
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