Publications: Dr Jun Wang
Jiang G, Wang Z, Cheng Z, Wang W, Lu S, Zhang Z, Anene CA, Khan F et al.
(
2024
)
.
The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma
.
Nature Communications
vol.
15
,
(
1
)
Kumar EA, Korfi K, Bewicke‐Copley F, Close K, Heward J, Witzig T, Leukam M, Ansell S et al.
(
2024
)
.
CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma
.
British Journal of Haematology
Constantinou M, Nicholson J, Zhang X, Maniati E, Lucchini S, Rosser G, Vinel C, Wang J et al.
(
2024
)
.
Lineage specification in glioblastoma is regulated by METTL7B
.
Cell Reports
vol.
43
,
(
6
)
Njegić A, Laid L, Zi M, Maniati E, Wang J, Chelu A, Wisniewski L, Hunter J et al.
(
2024
)
.
Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice
.
Journal of Molecular and Cellular Cardiology Plus
vol.
8
,
Zheng J, Bewicke-Copley F, Vermeulen C, Casado P, Kaya F, Demeulemeester J, Guscott M, Krizsán S et al.
(
2023
)
.
Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML
.
Blood
vol.
142
,
(
Supplement 1
)
Kaya F, Bewicke-Copley F, Izquierdo PC, Zheng J, Miettinen JJ, Khan N, Krizsán S, Saad JJ et al.
(
2023
)
.
The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients
.
Blood
vol.
142
,
(
Supplement 1
)
Wang J, Harwood C, Bailey E, Bewicke-Copley F, Anene C, Thomson J, Qamar M, Nourse C et al.
(
2023
)
.
LB1663 A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis
.
Journal of Investigative Dermatology
vol.
143
,
(
9
)
Bailey P, Ridgway RA, Cammareri P, Treanor-Taylor M, Bailey U-M, Schoenherr C, Bone M, Schreyer D et al.
(
2023
)
.
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression
.
Nature Communications
vol.
14
,
(
1
)
Baleeiro RB, Liu P, Dunmall LSC, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al.
(
2023
)
.
Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer
.
Journal for ImmunoTherapy of Cancer
vol.
11
,
(
8
)
Wang J, Harwood CA, Bailey E, Bewicke-Copley F, Anene CA, Thomson J, Qamar MJ, Laban R et al.
(
2023
)
.
Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis
.
Journal of the American Academy of Dermatology
vol.
89
,
(
6
)
1159
-
1166
.
Thomson J, Harwoood C, Strid J, Healy E, Wang J
(
2023
)
.
O02 Neoantigens from actinic keratosis are predicted to be more immunogenic than those from cutaneous squamous cell carcinoma – a strategy for immune escape?
.
British Journal of Dermatology
vol.
189
,
(
1
)
e4
-
e5
.
Peleva E, Chen Y, Rizvi H, Harwood C, Wang J
(
2023
)
.
010 Enhanced outcome prediction in cutaneous squamous cell carcinoma using deep-learning and computational histopathology (cSCCnet)
.
British Journal of Dermatology
vol.
188
,
(
Supplement_4
)
Thomson J, Healy E, Strid J, Harwood C, Wang J
(
2023
)
.
274 Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype
.
Journal of Investigative Dermatology
vol.
143
,
(
5
)
Philippe C, Mian S, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al.
(
2023
)
.
O20 TARGETING THE DEFECTIVE COA PATHWAY TO IMPROVE ERYTHROPOIESIS IN SF3B1-MUTANT MDS-RS PATIENTS
.
Leukemia Research
vol.
128
,
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S et al.
(
2023
)
.
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma
.
Blood Advances
vol.
7
,
(
5
)
845
-
855
.
Rozowsky J, Gao J, Borsari B, Yang YT, Galeev T, Gürsoy G, Epstein CB, Xiong K et al.
(
2023
)
.
The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models
.
Cell
vol.
186
,
(
7
)
1493
-
1511.e40
.
Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al.
(
2023
)
.
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia
.
Science Translational Medicine
vol.
15
,
(
685
)
eabn5135
-
eabn5135
.
Knight CH, Khan F, Patel A, Gill US, Okosun J, Wang J
(
2023
)
.
IBRAP: integrated benchmarking single-cell RNA-sequencing analytical pipeline
.
Briefings in Bioinformatics
vol.
24
,
(
2
)
Wang J, Harwood C, Bailey E, Bewicke-Copley F, Anene C, Thomson J, Qamar M, Nourse C et al.
(
2023
)
.
A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
143
,
B8
-
B8
.
Baleeiro R, Liu P, Chard LS, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al.
(
2023
)
.
Emerging Data from the Use of TILT-123, an Oncolytic Adenovirus Armed with TNFa and IL-2 in Patients with Solid Tumors
.
MOLECULAR THERAPY
.
vol.
31
,
154
-
154
.
Thomson J, Healy E, Strid J, Harwood C, Wang J
(
2023
)
.
Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
143
,
S47
-
S47
.
Rio-Machin A, Bewicke-Copley F, Zheng J, Izquierdo PC, Miettinen JJ, Khan N, Demeulemeester J, Krizsán S et al.
(
2022
)
.
Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML
.
Blood
vol.
140
,
(
Supplement 1
)
1030
-
1032
.
Perrett M, Pickard L, Kumar E, Palladino G, Khan F, Edmondson C, Knight C, Poynton E et al.
(
2022
)
.
Longitudinal Single Cell Analyses Reveal the Co-Evolutionary Dynamics of the Tumor and Microenvironment Accompanying Follicular Lymphoma Transformation
.
Blood
vol.
140
,
(
Supplement 1
)
748
-
749
.
Shaikh N, Mazzagatti A, De Angelis S, Johnson SC, Bakker B, Spierings DCJ, Wardenaar R, Maniati E et al.
(
2022
)
.
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
.
Genome Biology
vol.
23
,
(
1
)
Armes H, Bewicke‐Copley F, Rio‐Machin A, Di Bella D, Philippe C, Wozniak A, Tummala H, Wang J et al.
(
2022
)
.
Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment
.
British Journal of Haematology
vol.
199
,
(
5
)
754
-
764
.
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B et al.
(
2022
)
.
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
.
Development
vol.
149
,
(
13
)
Wang Z, Cheng Z, Lu S, Dunmall LSC, Wang J, Guo Y, Wang Y
(
2022
)
.
Characterization of the Intra-tumoral B Cell Immunoglobulin Repertoire Is of Prognostic Value for Esophageal Squamous Cell Carcinoma
.
Frontiers in Immunology
vol.
13
,
Anene CA, Taggart E, Harwood CA, Pennington DJ, Wang J
(
2022
)
.
Decosus: An R Framework for Universal Integration of Cell Proportion Estimation Methods
.
Frontiers in Genetics
vol.
13
,
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
(
2022
)
.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
.
Cell Reports
vol.
38
,
(
4
)
Walne AJ, Vulliamy T, Bewicke-Copley F, Wang J, Alnajar J, Bridger MG, Ma B, Tummala H et al.
(
2021
)
.
Genome-wide whole-blood transcriptome profiling across inherited bone marrow failure subtypes
.
Blood Advances
vol.
5
,
(
23
)
5360
-
5371
.
Mian S, Philippe C, Maniati E, Bergot T, Piganeau M, Di Bella D, Morales V, Finch A et al.
(
2021
)
.
Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia
.
Blood
vol.
138
,
(
Supplement 1
)
Keane L, Antignano I, Riechers S-P, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J et al.
(
2021
)
.
mTOR-dependent translation amplifies microglia priming in aging mice
.
Journal of Clinical Investigation
vol.
131
,
(
20
)
Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B et al.
(
2021
)
.
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections
.
Science Advances
vol.
7
,
(
37
)
Anene CA, Khan F, Bewicke-Copley F, Maniati E, Wang J
(
2021
)
.
ACSNI: An unsupervised machine-learning tool for prediction of tissue-specific pathway components using gene expression profiles
.
Patterns
vol.
2
,
(
6
)
Article
100270
,
100270
-
100270
.
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al.
(
2021
)
.
Correction to ‘Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma’
.
NAR Cancer
vol.
3
,
(
2
)
Heward J, Konali L, D'Avola A, Close K, Yeomans A, Philpott M, Dunford J, Rahim T et al.
(
2021
)
.
KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas
.
Blood
vol.
138
,
(
5
)
370
-
381
.
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al.
(
2021
)
.
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
.
NAR Cancer
vol.
3
,
(
1
)
Tse WY, Maniati E, Wang J, Lockley M, Martin S
.
Identification of a novel regulator of FANCD2 mediated DNA Repair
.
Conference:
Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response
Thomson J, Bewicke-Copley F, Anene CA, Gulati A, Nagano A, Purdie K, Inman GJ, Proby CM et al.
(
2021
)
.
The Genomic Landscape of Actinic Keratosis
.
Journal of Investigative Dermatology
vol.
141
,
(
7
)
1664
-
1674.e7
.
Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al.
(
2021
)
.
The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis
.
Cancers
vol.
13
,
(
2
)
Larrea E, Fernandez-Mercado M, Guerra-Assunção JA, Wang J, Goicoechea I, Gaafar A, Ceberio I, Lobo C et al.
(
2020
)
.
Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma
.
International Journal of Molecular Sciences
vol.
21
,
(
22
)
Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al.
(
2020
)
.
Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia
.
Blood
vol.
136
,
(
Supplement 1
)
39
-
40
.
Uyulur F, Bewicke-Copley F, Anene CA, Schlesner M, Project IM-S, Siebert R, Okosun J, Fitzgibbon J et al.
(
2020
)
.
Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma
.
Blood
vol.
136
,
(
Supplement 1
)
26
-
27
.
Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D et al.
(
2020
)
.
Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma
.
Cancer Research
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al.
(
2020
)
.
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
.
npj Breast Cancer
vol.
6
,
(
1
)
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al.
(
2020
)
.
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
.
NPJ Breast Cancer
vol.
6
,
(
1
)
Iacovazzo D, Thong LC, Quezado R, Drummond J, Antonio DSBF, Cuenco J, Brändle M, Walker E et al.
(
2020
)
.
The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators
.
Endocrine Abstracts
Dokal I, Tummala H, Vulliamy T, Walne A
(
2020
)
.
A frameshift variant in the specificity protein 1 triggers superactivation of SP1-mediated transcription in familial bone marrow failure
.
Proceedings of the National Academy of Sciences of USA
Article
32636268
,
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K
(
2020
)
.
Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance
.
Cancer Research
.
vol.
80
,
a31
-
a31
.
Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al.
(
2020
)
.
Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma
.
Haematologica
vol.
105
,
(
6
)
318
-
321
.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al.
(
2020
)
.
Cancer associated fibroblast FAK regulates malignant cell metabolism
.
Nature Communications
vol.
11
,
(
1
)
1290
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1290
.
Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N et al.
(
2020
)
.
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
.
Nature Communications
vol.
11
,
(
1
)
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al.
(
2020
)
.
A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer
.
Clinical Cancer Research
vol.
26
,
(
2
)
465
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476
.
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K
(
2020
)
.
Tumor stroma in the development of acquired cancer therapy resistance
.
CANCER RESEARCH
.
vol.
80
,
48
-
48
.
Bewicke-Copley F, Korfi K, Araf S, Kumar EA, Cummin TEC, Ashton-Key M, Barrans S, Van Hoppe S et al.
(
2019
)
.
Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel
.
Blood
vol.
134
,
(
Supplement_1
)
Bewicke-Copley F, Kumar EA, Palladino G, Korfi K, Wang J
(
2019
)
.
Applications and analysis of targeted genomic sequencing in cancer studies
.
Computational and Structural Biotechnology Journal
vol.
17
,
1348
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1359
.
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.
(
2019
)
.
Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease
.
The Journal of Pathology
vol.
249
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(
4
)
523
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535
.
Brown P, Tan A-C, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF, Cernava T et al.
(
2019
)
.
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
.
Database
vol.
2019
,
Martin S
(
2019
)
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MLH1 deficiency leads to deregulated mitochondrial metabolism
.
Cell Death and Disease
vol.
10
,
795
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795
.
Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al.
(
2019
)
.
423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer
.
Journal of Investigative Dermatology
.
vol.
139
,
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al.
(
2019
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.
A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing
.
International Journal of Molecular Sciences
vol.
20
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(
14
)
Kumar E, Korfi K, Bewicke‐Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al.
(
2019
)
.
PF513 MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
.
HemaSphere
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3
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S1
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Korfi K, Araf S, Bewicke‐Copley F, Kumar E, Cummin T, Ashton‐Key M, Barrans S, Van Hoppe S et al.
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2019
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.
LONGITUDINAL ANALYSES OF DIAGNOSTIC‐RELAPSE BIOPSIES OF DIFFUSE LARGE B CELL LYMPHOMA SUGGEST THAT RELAPSE IS MEDIATED BY DISTINCT MECHANISMS IN ABC AND GCB LYMPHOMA
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Hematological Oncology
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37
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142
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Kumar E, Korfi K, Bewicke-Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al.
(
2019
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MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
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HemaSphere
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3
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Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
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454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus
.
Journal of Investigative Dermatology
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139
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5
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Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al.
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2019
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Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant
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Haematologica
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104
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4
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e174
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Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.
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2019
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Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
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Leukemia
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33
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1540
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Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al.
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2019
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Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma
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Journal of Investigative Dermatology
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139
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8
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1658
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1671.e8
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Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
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2019
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iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus
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JOURNAL OF INVESTIGATIVE DERMATOLOGY
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139
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S78
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Patel MB, Wang J
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The Identification and Interpretation of cis-Regulatory Noncoding Mutations in Cancer
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BioTech
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8
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1
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Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al.
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2018
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The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
.
Nature Communications
vol.
9
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(
1
)
Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O’Toole EA et al.
(
2018
)
.
MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma
.
Scientific Reports
vol.
8
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(
1
)
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C
(
2018
)
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SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine
.
Nucleic Acids Research
vol.
46
,
(
W1
)
w109
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w113
.
Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A et al.
(
2018
)
.
CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype
.
Cell Reports
vol.
23
,
(
5
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1448
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1460
.
Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S et al.
(
2018
)
.
GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML
.
Leukemia
vol.
32
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(
11
)
2502
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2507
.
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al.
(
2018
)
.
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
.
Cell Reports
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22
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(
9
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2469
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