Publications: Dr Jun Wang
Jiang G, Wang Z, Cheng Z, Wang W, Lu S, Zhang Z, Anene CA, Khan F et al.
(
2024
)
.
The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma
.
Nature Communications
vol.
15
,
(
1
)
Kumar EA, Korfi K, Bewicke‐Copley F, Close K, Heward J, Witzig T, Leukam M, Ansell S et al.
(
2024
)
.
CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma
.
British Journal of Haematology
Constantinou M, Nicholson J, Zhang X, Maniati E, Lucchini S, Rosser G, Vinel C, Wang J et al.
(
2024
)
.
Lineage specification in glioblastoma is regulated by METTL7B
.
Cell Reports
vol.
43
,
(
6
)
Njegić A, Laid L, Zi M, Maniati E, Wang J, Chelu A, Wisniewski L, Hunter J et al.
(
2024
)
.
Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice
.
Journal of Molecular and Cellular Cardiology Plus
vol.
8
,
Zheng J, Bewicke-Copley F, Vermeulen C, Casado P, Kaya F, Demeulemeester J, Guscott M, Krizsán S et al.
(
2023
)
.
Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML
.
Blood
vol.
142
,
(
Supplement 1
)
Kaya F, Bewicke-Copley F, Izquierdo PC, Zheng J, Miettinen JJ, Khan N, Krizsán S, Saad JJ et al.
(
2023
)
.
The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients
.
Blood
vol.
142
,
(
Supplement 1
)
Wang J, Harwood C, Bailey E, Bewicke-Copley F, Anene C, Thomson J, Qamar M, Nourse C et al.
(
2023
)
.
LB1663 A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis
.
Journal of Investigative Dermatology
vol.
143
,
(
9
)
Bailey P, Ridgway RA, Cammareri P, Treanor-Taylor M, Bailey U-M, Schoenherr C, Bone M, Schreyer D et al.
(
2023
)
.
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression
.
Nature Communications
vol.
14
,
(
1
)
Baleeiro RB, Liu P, Dunmall LSC, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al.
(
2023
)
.
Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer
.
Journal for ImmunoTherapy of Cancer
vol.
11
,
(
8
)
Wang J, Harwood CA, Bailey E, Bewicke-Copley F, Anene CA, Thomson J, Qamar MJ, Laban R et al.
(
2023
)
.
Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis
.
Journal of the American Academy of Dermatology
vol.
89
,
(
6
)
1159
-
1166
.
Thomson J, Harwoood C, Strid J, Healy E, Wang J
(
2023
)
.
O02 Neoantigens from actinic keratosis are predicted to be more immunogenic than those from cutaneous squamous cell carcinoma – a strategy for immune escape?
.
British Journal of Dermatology
vol.
189
,
(
1
)
e4
-
e5
.
Peleva E, Chen Y, Rizvi H, Harwood C, Wang J
(
2023
)
.
010 Enhanced outcome prediction in cutaneous squamous cell carcinoma using deep-learning and computational histopathology (cSCCnet)
.
British Journal of Dermatology
vol.
188
,
(
Supplement_4
)
Thomson J, Healy E, Strid J, Harwood C, Wang J
(
2023
)
.
274 Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype
.
Journal of Investigative Dermatology
vol.
143
,
(
5
)
Philippe C, Mian S, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al.
(
2023
)
.
O20 TARGETING THE DEFECTIVE COA PATHWAY TO IMPROVE ERYTHROPOIESIS IN SF3B1-MUTANT MDS-RS PATIENTS
.
Leukemia Research
vol.
128
,
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S et al.
(
2023
)
.
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma
.
Blood Advances
vol.
7
,
(
5
)
845
-
855
.
Rozowsky J, Gao J, Borsari B, Yang YT, Galeev T, Gürsoy G, Epstein CB, Xiong K et al.
(
2023
)
.
The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models
.
Cell
vol.
186
,
(
7
)
1493
-
1511.e40
.
Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al.
(
2023
)
.
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia
.
Science Translational Medicine
vol.
15
,
(
685
)
eabn5135
-
eabn5135
.
Knight CH, Khan F, Patel A, Gill US, Okosun J, Wang J
(
2023
)
.
IBRAP: integrated benchmarking single-cell RNA-sequencing analytical pipeline
.
Briefings in Bioinformatics
vol.
24
,
(
2
)
Wang J, Harwood C, Bailey E, Bewicke-Copley F, Anene C, Thomson J, Qamar M, Nourse C et al.
(
2023
)
.
A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
143
,
B8
-
B8
.
Baleeiro R, Liu P, Chard LS, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al.
(
2023
)
.
Emerging Data from the Use of TILT-123, an Oncolytic Adenovirus Armed with TNFa and IL-2 in Patients with Solid Tumors
.
MOLECULAR THERAPY
.
vol.
31
,
154
-
154
.
Thomson J, Healy E, Strid J, Harwood C, Wang J
(
2023
)
.
Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
143
,
S47
-
S47
.
Rio-Machin A, Bewicke-Copley F, Zheng J, Izquierdo PC, Miettinen JJ, Khan N, Demeulemeester J, Krizsán S et al.
(
2022
)
.
Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML
.
Blood
vol.
140
,
(
Supplement 1
)
1030
-
1032
.
Perrett M, Pickard L, Kumar E, Palladino G, Khan F, Edmondson C, Knight C, Poynton E et al.
(
2022
)
.
Longitudinal Single Cell Analyses Reveal the Co-Evolutionary Dynamics of the Tumor and Microenvironment Accompanying Follicular Lymphoma Transformation
.
Blood
vol.
140
,
(
Supplement 1
)
748
-
749
.
Shaikh N, Mazzagatti A, De Angelis S, Johnson SC, Bakker B, Spierings DCJ, Wardenaar R, Maniati E et al.
(
2022
)
.
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
.
Genome Biology
vol.
23
,
(
1
)
Armes H, Bewicke‐Copley F, Rio‐Machin A, Di Bella D, Philippe C, Wozniak A, Tummala H, Wang J et al.
(
2022
)
.
Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment
.
British Journal of Haematology
vol.
199
,
(
5
)
754
-
764
.
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B et al.
(
2022
)
.
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
.
Development
vol.
149
,
(
13
)
Wang Z, Cheng Z, Lu S, Dunmall LSC, Wang J, Guo Y, Wang Y
(
2022
)
.
Characterization of the Intra-tumoral B Cell Immunoglobulin Repertoire Is of Prognostic Value for Esophageal Squamous Cell Carcinoma
.
Frontiers in Immunology
vol.
13
,
Anene CA, Taggart E, Harwood CA, Pennington DJ, Wang J
(
2022
)
.
Decosus: An R Framework for Universal Integration of Cell Proportion Estimation Methods
.
Frontiers in Genetics
vol.
13
,
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
(
2022
)
.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
.
Cell Reports
vol.
38
,
(
4
)
Walne AJ, Vulliamy T, Bewicke-Copley F, Wang J, Alnajar J, Bridger MG, Ma B, Tummala H et al.
(
2021
)
.
Genome-wide whole-blood transcriptome profiling across inherited bone marrow failure subtypes
.
Blood Advances
vol.
5
,
(
23
)
5360
-
5371
.
Mian S, Philippe C, Maniati E, Bergot T, Piganeau M, Di Bella D, Morales V, Finch A et al.
(
2021
)
.
Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia
.
Blood
vol.
138
,
(
Supplement 1
)
Keane L, Antignano I, Riechers S-P, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J et al.
(
2021
)
.
mTOR-dependent translation amplifies microglia priming in aging mice
.
Journal of Clinical Investigation
vol.
131
,
(
20
)
Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B et al.
(
2021
)
.
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections
.
Science Advances
vol.
7
,
(
37
)
Anene CA, Khan F, Bewicke-Copley F, Maniati E, Wang J
(
2021
)
.
ACSNI: An unsupervised machine-learning tool for prediction of tissue-specific pathway components using gene expression profiles
.
Patterns
vol.
2
,
(
6
)
Article
100270
,
100270
-
100270
.
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al.
(
2021
)
.
Correction to ‘Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma’
.
NAR Cancer
vol.
3
,
(
2
)
Heward J, Konali L, D'Avola A, Close K, Yeomans A, Philpott M, Dunford J, Rahim T et al.
(
2021
)
.
KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas
.
Blood
vol.
138
,
(
5
)
370
-
381
.
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al.
(
2021
)
.
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
.
NAR Cancer
vol.
3
,
(
1
)
Tse WY, Maniati E, Wang J, Lockley M, Martin S
.
Identification of a novel regulator of FANCD2 mediated DNA Repair
.
Conference:
Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response
Thomson J, Bewicke-Copley F, Anene CA, Gulati A, Nagano A, Purdie K, Inman GJ, Proby CM et al.
(
2021
)
.
The Genomic Landscape of Actinic Keratosis
.
Journal of Investigative Dermatology
vol.
141
,
(
7
)
1664
-
1674.e7
.
Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al.
(
2021
)
.
The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis
.
Cancers
vol.
13
,
(
2
)
Larrea E, Fernandez-Mercado M, Guerra-Assunção JA, Wang J, Goicoechea I, Gaafar A, Ceberio I, Lobo C et al.
(
2020
)
.
Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma
.
International Journal of Molecular Sciences
vol.
21
,
(
22
)
Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al.
(
2020
)
.
Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia
.
Blood
vol.
136
,
(
Supplement 1
)
39
-
40
.
Uyulur F, Bewicke-Copley F, Anene CA, Schlesner M, Project IM-S, Siebert R, Okosun J, Fitzgibbon J et al.
(
2020
)
.
Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma
.
Blood
vol.
136
,
(
Supplement 1
)
26
-
27
.
Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D et al.
(
2020
)
.
Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma
.
Cancer Research
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al.
(
2020
)
.
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
.
npj Breast Cancer
vol.
6
,
(
1
)
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al.
(
2020
)
.
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
.
NPJ Breast Cancer
vol.
6
,
(
1
)
Iacovazzo D, Thong LC, Quezado R, Drummond J, Antonio DSBF, Cuenco J, Brändle M, Walker E et al.
(
2020
)
.
The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators
.
Endocrine Abstracts
Dokal I, Tummala H, Vulliamy T, Walne A
(
2020
)
.
A frameshift variant in the specificity protein 1 triggers superactivation of SP1-mediated transcription in familial bone marrow failure
.
Proceedings of the National Academy of Sciences of USA
Article
32636268
,
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K
(
2020
)
.
Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance
.
Cancer Research
.
vol.
80
,
a31
-
a31
.
Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al.
(
2020
)
.
Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma
.
Haematologica
vol.
105
,
(
6
)
318
-
321
.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al.
(
2020
)
.
Cancer associated fibroblast FAK regulates malignant cell metabolism
.
Nature Communications
vol.
11
,
(
1
)
1290
-
1290
.
Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N et al.
(
2020
)
.
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
.
Nature Communications
vol.
11
,
(
1
)
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al.
(
2020
)
.
A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer
.
Clinical Cancer Research
vol.
26
,
(
2
)
465
-
476
.
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K
(
2020
)
.
Tumor stroma in the development of acquired cancer therapy resistance
.
CANCER RESEARCH
.
vol.
80
,
48
-
48
.
Bewicke-Copley F, Korfi K, Araf S, Kumar EA, Cummin TEC, Ashton-Key M, Barrans S, Van Hoppe S et al.
(
2019
)
.
Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel
.
Blood
vol.
134
,
(
Supplement_1
)
Bewicke-Copley F, Kumar EA, Palladino G, Korfi K, Wang J
(
2019
)
.
Applications and analysis of targeted genomic sequencing in cancer studies
.
Computational and Structural Biotechnology Journal
vol.
17
,
1348
-
1359
.
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.
(
2019
)
.
Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease
.
The Journal of Pathology
vol.
249
,
(
4
)
523
-
535
.
Brown P, Tan A-C, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF, Cernava T et al.
(
2019
)
.
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
.
Database
vol.
2019
,
Martin S
(
2019
)
.
MLH1 deficiency leads to deregulated mitochondrial metabolism
.
Cell Death and Disease
vol.
10
,
795
-
795
.
Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al.
(
2019
)
.
423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer
.
Journal of Investigative Dermatology
.
vol.
139
,
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al.
(
2019
)
.
A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing
.
International Journal of Molecular Sciences
vol.
20
,
(
14
)
Kumar E, Korfi K, Bewicke‐Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al.
(
2019
)
.
PF513 MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
.
HemaSphere
vol.
3
,
(
S1
)
Korfi K, Araf S, Bewicke‐Copley F, Kumar E, Cummin T, Ashton‐Key M, Barrans S, Van Hoppe S et al.
(
2019
)
.
LONGITUDINAL ANALYSES OF DIAGNOSTIC‐RELAPSE BIOPSIES OF DIFFUSE LARGE B CELL LYMPHOMA SUGGEST THAT RELAPSE IS MEDIATED BY DISTINCT MECHANISMS IN ABC AND GCB LYMPHOMA
.
Hematological Oncology
vol.
37
,
(
S2
)
142
-
143
.
Kumar E, Korfi K, Bewicke-Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al.
(
2019
)
.
MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
.
HemaSphere
vol.
3
,
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
(
2019
)
.
454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus
.
Journal of Investigative Dermatology
vol.
139
,
(
5
)
Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al.
(
2019
)
.
Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant
.
Haematologica
vol.
104
,
(
4
)
e174
-
e177
.
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.
(
2019
)
.
Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
.
Leukemia
vol.
33
,
(
6
)
1540
-
1540
.
Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al.
(
2019
)
.
Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma
.
Journal of Investigative Dermatology
vol.
139
,
(
8
)
1658
-
1671.e8
.
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
(
2019
)
.
iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
139
,
S78
-
S78
.
Patel MB, Wang J
(
2018
)
.
The Identification and Interpretation of cis-Regulatory Noncoding Mutations in Cancer
.
BioTech
vol.
8
,
(
1
)
Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al.
(
2018
)
.
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
.
Nature Communications
vol.
9
,
(
1
)
Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O’Toole EA et al.
(
2018
)
.
MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma
.
Scientific Reports
vol.
8
,
(
1
)
Ullah AZD, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C
(
2018
)
.
SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine
.
Nucleic Acids Research
vol.
46
,
(
W1
)
w109
-
w113
.
Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A et al.
(
2018
)
.
CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype
.
Cell Reports
vol.
23
,
(
5
)
1448
-
1460
.
Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S et al.
(
2018
)
.
GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML
.
Leukemia
vol.
32
,
(
11
)
2502
-
2507
.
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al.
(
2018
)
.
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
.
Cell Reports
vol.
22
,
(
9
)
2469
-
2481
.
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.
(
2018
)
.
Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
.
Leukemia
vol.
32
,
(
5
)
1261
-
1265
.
Wang J, Ullah AZD, Chelala C
(
2018
)
.
IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome
.
Nucleic Acids Research
vol.
46
,
(
8
)
e47
-
e47
.
Al Seraihi AF, Rio-Machin A, Tawana K, Bodor C, Wang J, Nagano A, Heward JA, Iqbal S et al.
(
2018
)
.
<i>GATA2</i> monoallelic expression underlies reduced penetrance in inherited <i>GATA2</i>-mutated MDS/AML
.
LEUKEMIA
vol.
32
,
(
11
)
2502
-
2507
.
Thomson J, Proby C, Leigh I, Nagano A, Harwood C, Inmann G, Wang J
(
2018
)
.
Exome sequencing of a cohort of actinic keratoses to identify significantly mutated genes
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
178
,
E400
-
E400
.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.
(
2017
)
.
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers
.
Cancer Discov
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J et al.
(
2017
)
.
Lamin B1 regulates somatic mutations and progression of B-cell malignancies
.
Leukemia
vol.
32
,
(
2
)
364
-
375
.
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al.
(
2017
)
.
'Multi-omic' data analysis using O-miner
.
Brief Bioinform
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M
(
2017
)
.
Abstract 5558: Deconstruction of a human tumor microenvironment
.
Cancer Research
.
vol.
77
,
5558
-
5558
.
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Wang J, Fischer K, Akylzhanova G, Edelmann J et al.
(
2017
)
.
NUCLEAR LAMINA REGULATES SOMATIC HYPERMUTATION AND PROGRESSION OF B CELL MALIGNANCIES
.
HAEMATOLOGICA
.
Conference:
EHA
vol.
102
,
228
-
228
.
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al.
(
2017
)
.
Splice variants as novel targets in pancreatic ductal adenocarcinoma
.
Scientific Reports
vol.
7
,
(
1
)
Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al.
(
2017
)
.
Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree
.
European Journal of Human Genetics
vol.
25
,
(
8
)
1020
-
1024
.
Ironside A, Hawkesford K, Gomm J, Haywood L, Goulding I, Wang J, Lamaziere A, Poirot M et al.
(
2017
)
.
Molecular mediators of mammographic density
.
CANCER RESEARCH
.
Conference:
2016 San Antonio Breast Cancer Symposium
from:
06/12/2016
to:
10/12/2016
,
vol.
77
,
Harwood C, Proby C, Wang J, Nagano A, Alexandrov L, Purdie K, Chelala C, Inman G et al.
(
2017
)
.
Chronic azathioprine treatment is causal in cutaneous squamous cell carcinoma development and is associated with a novel mutational signature
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
177
,
9
-
10
.
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward JA et al.
(
2017
)
.
Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma
.
BLOOD
.
vol.
130
,
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al.
(
2016
)
.
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia
.
LEUKEMIA
vol.
30
,
(
11
)
2179
-
2186
.
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al.
(
2016
)
.
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
.
Nature Communications
vol.
7
,
12493
-
12493
.
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al.
(
2016
)
.
Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1
.
Cell Reports
vol.
16
,
(
6
)
1604
-
1613
.
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al.
(
2016
)
.
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia
.
Leukemia
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al.
(
2016
)
.
Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma
.
Cancer Research
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al.
(
2016
)
.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016)
.
NATURE GENETICS
vol.
48
,
(
6
)
700
-
700
.
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al.
(
2016
)
.
Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
.
Nat Genet
vol.
48
,
(
6
)
700
-
700
.
Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al.
(
2016
)
.
Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease
.
Leukemia
vol.
30
,
(
6
)
1301
-
1310
.
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al.
(
2016
)
.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
.
Nature Genetics
vol.
48
,
(
2
)
183
-
188
.
Proby C, Inman G, Wang J, Nagano A, Purdie K, Mladkova N, Lambert S, Gulati A et al.
(
2016
)
.
Characterisation of the molecular landscape of cutaneous squamous cell carcinoma
.
MELANOMA RESEARCH
.
vol.
26
,
E69
-
E69
.
Proby CM, Inman G, Wang JA, Nagano A, Purdie KJ, Gulati A, Lambert S, Mladkova N et al.
(
2016
)
.
Characterisation of the molecular landscape of cutaneous squamous cell carcinoma and Identification of a novel mutational signature associated with chronic azathioprine exposure
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
175
,
58
-
59
.
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, Ridgway R, Mchugh A et al.
(
2016
)
.
Frequent loss of function mutations in TGFβR1 and TGFβR2 implicate hair follicle bulge stem cells as a cell of origin of cutaneous squamous cell carcinoma
.
MELANOMA RESEARCH
.
vol.
26
,
E63
-
E64
.
Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al.
(
2016
)
.
GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE
.
HAEMATOLOGICA
.
vol.
101
,
270
-
270
.
Inman G, Proby CM, Wang JA, Nagano A, Alexandrov L, Purdie K, Rose A, Weir L et al.
(
2016
)
.
Identification of a novel mutational signature in cutaneous SCC associated with chronic azathioprine exposure
.
MELANOMA RESEARCH
.
vol.
26
,
E114
-
E115
.
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Coates P, Sapkota G, Purdie K et al.
(
2016
)
.
Inactivation of transforming growth factor-β receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
174
,
E51
-
E52
.
Proby C, Inman G, Nagano A, Purdie K, Mladkova N, Alexandrov L, Stratton M, Watt S et al.
(
2016
)
.
The molecular landscape of cutaneous squamous cell carcinoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
174
,
E50
-
E51
.
Rio-Machin A, Cardoso S, Tawana K, Wang J, Chelala C, Plagnol V, Wallis Y, Ryan G et al.
(
2016
)
.
WHOLE EXOME SEQUENCING REVEALS NOVEL CANDIDATE GENES IN FAMILIAL MDS/AML
.
HAEMATOLOGICA
.
vol.
101
,
205
-
206
.
Rose-Zerilli MJJ, Parker H, Larrayoz M, Clifford R, Blakemore S, Edelmann J, Gibson J, Wang J et al.
(
2015
)
.
Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia
.
Blood
vol.
126
,
(
23
)
Parry M, Rose-Zerilli MJJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A et al.
(
2015
)
.
Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing
.
Clinical Cancer Research
vol.
21
,
(
18
)
4174
-
4183
.
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al.
(
2015
)
.
Disease evolution and outcomes in familial AML with germline CEBPA mutations
.
Blood
vol.
126
,
(
10
)
1214
-
1223
.
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y
(
2015
)
.
Efficiently Editing the Vaccinia Virus Genome by Using the CRISPR-Cas9 System
.
Journal of Virology
vol.
89
,
(
9
)
5176
-
5179
.
Tawana K, Wang J, Kiraly PA, Kallay K, Benyo G, Krivan G, Csomor J, Fitzgibbon J et al.
(
2015
)
.
CONVERGENCE OF SOMATIC MUTATIONS WITHIN THE JAK-STAT SIGNALLING PATHWAY IN A NOVEL RUNX1-MUTATED PEDIGREE
.
HAEMATOLOGICA
.
vol.
100
,
9
-
10
.
Nagano A, Purdie K, Pourreyron C, McHugh A, Xue D, Wright S, Dayal J, Watt S et al.
(
2015
)
.
Cutaneous squamous cell carcinoma cell lines retain the genetic signature of human cutaneous squamous cell carcinoma and recapitulate the histology of the original human tumour in mouse xenograft models
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
172
,
E43
-
E44
.
Koniali L, Heward J, Loveday C, Wilkins L, Ishfaq M, Wang J, Okosun J, Packham G et al.
(
2015
)
.
KDM5 INHIBITION LEADS TO INCREASED H3K4ME3 LEVELS AND CELL DEATH IN GERMINAL CENTRE LYMPHOMA CELL LINES INDEPENDENT OF MLL2 MUTATION STATUS
.
HAEMATOLOGICA
.
vol.
100
,
104
-
104
.
Rose-Zerilli MJ, Parry M, Ljungstrom V, Gibson J, Wang J, Walewska R, Parker H, Parker A et al.
(
2014
)
.
Deep-Sequencing Reveals the Molecular Landscape of Splenic Marginal Zone Lymphoma: Biological and Clinical Implications
.
Blood
.
vol.
124
,
Rose-Zerilli MJ, Jane G, Wang J, Tapper WJ, Parker H, Parker A, Davis Z, Gardiner AC et al.
(
2014
)
.
Tracking Subclonal Mutations in IGHV-Mutated CLL with Progressive Disease
.
Blood
.
vol.
124
,
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al.
(
2014
)
.
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma
.
Genome Medicine
vol.
6
,
(
12
)
Kadaba R, Birke H, DiMaggio F, Wang J, Chelala C, Sasieni P, Kocher HM
(
2012
)
.
Abstract B100: The proportion of pancreatic stellate cells plays a critical role in modulating pancreatic cancer cell behavior
.
Conference:
Tumor Biologyb100
-
b100
.
Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al.
(
2014
)
.
Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia
.
Blood
vol.
123
,
(
13
)
2066
-
2074
.
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al.
(
2014
)
.
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
.
Nature Genetics
vol.
46
,
(
2
)
176
-
181
.
Okosun J, Bödör C, Wang J, Araf S, Yang C-Y, Pan C, Boller S, Cittaro D et al.
(
2014
)
.
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
.
Nat Genet
vol.
46
,
(
2
)
176
-
181
.
Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al.
(
2014
)
.
Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukaemia
.
BRITISH JOURNAL OF HAEMATOLOGY
.
vol.
165
,
16
-
16
.
Tawana K, Renneville A, Wang J, Georgiades P, Thomas X, Mialou V, Savic A, Van Delft FW et al.
(
2013
)
.
Familial AML With Germline CEBPA Mutations: Extended Clinical Outcomes and Analysis Of Secondary Mutations Using Whole Exome Sequencing
.
Blood
.
vol.
122
,
Manodoro F, Marzec J, Wang J, Chaplin T, Jovanovic JV, Eva M, Sameena I, Grimwade D et al.
(
2013
)
.
Loss of Imprinting at the 14q32 Domain Leads to MicroRNA Overexpression in Acute Promyelocytic Leukemia
.
Blood
.
vol.
122
,
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al.
(
2013
)
.
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
.
Gastroenterology
vol.
145
,
(
5
)
1121
-
1132
.
Bödör C, Grossmann V, Popov N, Okosun J, O'Riain C, Tan K, Marzec J, Araf S et al.
(
2013
)
.
EZH2 mutations are frequent and represent an early event in follicular lymphoma
.
Blood
vol.
122
,
(
18
)
3165
-
3168
.
Okosun J, Bödör C, Wang J, Araf S, Chelala C, Fitzgibbon J
(
2013
)
.
Genomic analysis reveals epigenetic ‘addiction’ underpinning follicular lymphoma and its transformation – a rationale for targeted epigenetic therapies
.
Clinical Epigenetics
vol.
5
,
(
Suppl 1
)
Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M et al.
(
2013
)
.
Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes
.
J Pathol
vol.
230
,
(
1
)
107
-
117
.
Love CG, Andongabo AE, Wang J, Carion PWC, Rawlings CJ, King GJ
(
2012
)
.
InterStoreDB: a generic integration resource for genetic and genomic data
.
J Integr Plant Biol
vol.
54
,
(
5
)
345
-
355
.
Manodoro F, Marzec J, Wang J, Chaplin T, Young B, Debernardi S
(
2012
)
.
DEEP SEQUENCING REVEALS ALLELE-SPECIFIC HYPERMETHYLATION AT 14Q32 IMPRINTED DOMAIN IN ACUTE PROMYELOCITIC LEUKAEMIA (APML)
.
HAEMATOLOGICA
.
vol.
97
,
14
-
14
.
Gilks WR, Welham SJ, Wang J, Clark SJ, King GJ
(
2012
)
.
Three-point appraisal of genetic linkage maps
.
THEORETICAL AND APPLIED GENETICS
vol.
125
,
(
7
)
1393
-
1402
.
Okosun J, Boedoer C, Wang J, Araf S, Marzec J, Iqbal S, Matthews J, Calaminici M et al.
(
2012
)
.
Whole Genome Sequencing in Sequential Biopsies Reveals the Genetic Evolution of Follicular Lymphoma to Transformed Follicular Lymphoma
.
BLOOD
.
vol.
120
,
Wang X, Wang H, Wang J, Sun R, Wu J, Liu S, Bai Y, Mun J-H et al.
(
2011
)
.
The genome of the mesopolyploid crop species Brassica rapa
.
Nature Genetics
vol.
43
,
(
10
)
1035
-
1039
.
Hammond JP, Mayes S, Bowen HC, Graham NS, Hayden RM, Love CG, Spracklen WP, Wang J et al.
(
2011
)
.
Regulatory Hotspots Are Associated with Plant Gene Expression under Varying Soil Phosphorus Supply in Brassica rapa
.
PLANT PHYSIOL
vol.
156
,
(
3
)
1230
-
1241
.
Wang J, Lydiate DJ, Parkin IAP, Falentin C, Delourme R, Carion PWC, King GJ
(
2011
)
.
Integration of linkage maps for the Amphidiploid Brassica napus and comparative mapping with Arabidopsis and Brassica rapa
.
BMC GENOMICS
vol.
12
,
Article
101
,
Wang J, Keightley PD, Halligan DL
(
2007
)
.
Effect of Divergence Time and Recombination Rate on Molecular Evolution of Drosophila INE-1 Transposable Elements and Other Candidates for Neutrally Evolving Sites
.
Journal of Molecular Evolution
vol.
65
,
(
6
)
Wang J, Keightley PD, Johnson T
(
2006
)
.
MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution
.
BMC Bioinformatics
vol.
7
,
(
1
)