Publications:  Dr Jun Wang

Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N et al.(2020). The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants. Nature Communications vol. 11, (1)

Dokal I, Tummala H, Vulliamy T, Walne A(2020). A frameshift variant in the specificity protein 1 triggers superactivation of SP1-mediated transcription in familial bone marrow failure. Proceedings of the National Academy of Sciences of USA Article 32636268,

Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al.(2020). Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma. Haematologica vol. 105, (6) E318-E321.

Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K (2020). Tumor stroma in the development of acquired cancer therapy resistance. CANCER RESEARCH. vol. 80, 48-48.

Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al.(2020). Cancer associated fibroblast FAK regulates malignant cell metabolism. Nature Communications vol. 11, (1) 1290-1290.

Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al.(2020). A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer. Clinical Cancer Research vol. 26, (2) 465-476.

Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.(2019). Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. Journal of Pathology vol. 249, (4) 523-535.

Martin S(2019). MLH1 deficiency leads to deregulated mitochondrial metabolism. Cell Death and Disease vol. 10, 795-795.

Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al. (2019). Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 139, S287-S287.

Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al.(2019). Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma. Journal of Investigative Dermatology vol. 139, (8) 1658-1671.e8.

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al.(2019). A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences vol. 20, (14)

Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.(2019). Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y). Leukemia vol. 33, (6)

Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. (2019). iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 139, S78-S78.

Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al.(2019). Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant. Haematologica vol. 104, (4) e174-e177.

Bewicke-Copley F, Arjun Kumar E, Palladino G, Korfi K, Wang J(2019). Applications and analysis of targeted genomic sequencing in cancer studies. Computational and Structural Biotechnology Journal vol. 17, 1348-1359.

Brown P, Zhou Y, Tan AC, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF et al.(2019). Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database vol. 2019, 1-67.

Patel MB, Wang J(2019). The identification and interpretation of cis-regulatory noncoding mutations in cancer. High-Throughput vol. 8, (1)

Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O'Toole EA et al.(2018). MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma. Scientific Reports vol. 8, (1)

Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al.(2018). The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications vol. 9, (1)

Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C(2018). SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine. Nucleic Acids Research vol. 46, (W1) W109-W113.

Thomson J, Proby C, Leigh I, Nagano A, Harwood C, Inmann G, Wang J (2018). Exome sequencing of a cohort of actinic keratoses to identify significantly mutated genes. BRITISH JOURNAL OF DERMATOLOGY. vol. 178, E400-E400.

Wang J, Dayem Ullah AZ, Chelala C(2018). IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome. Nucleic acids research vol. 46, (8)

Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A et al.(2018). CSF1R⁺ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype. Cell Reports vol. 23, (5) 1448-1460.

Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.(2018). Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia vol. 32, (5) 1258-1263.

Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S et al.(2018). GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML. Leukemia vol. 32, (11) 2502-2507.

Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al.(2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports vol. 22, (9) 2469-2481.

Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward JA et al. (2017). Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma. BLOOD. vol. 130,

Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.(2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov

Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al.(2017). Splice variants as novel targets in pancreatic ductal adenocarcinoma. Scientific Reports vol. 7, (1)

Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J et al.(2017). Lamin B1 regulates somatic mutations and progression of B-cell malignancies. Leukemia vol. 32, (2) 364-375.

Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al.(2017). 'Multi-omic' data analysis using O-miner. Brief Bioinform

Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al.(2017). Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree. European Journal of Human Genetics vol. 25, (8) 1020-1024.

Harwood C, Proby C, Wang J, Nagano A, Alexandrov L, Purdie K, Chelala C, Inman G et al. (2017). Chronic azathioprine treatment is causal in cutaneous squamous cell carcinoma development and is associated with a novel mutational signature. BRITISH JOURNAL OF DERMATOLOGY. vol. 177, 9-10.

Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M (2017). Deconstruction of a human tumor microenvironment. CANCER RESEARCH. vol. 77,

Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Wang J, Fischer K, Akylzhanova G, Edelmann J et al. (2017). NUCLEAR LAMINA REGULATES SOMATIC HYPERMUTATION AND PROGRESSION OF B CELL MALIGNANCIES. HAEMATOLOGICA. vol. 102, 228-228.

Ironside A, Hawkesford K, Gomm J, Haywood L, Goulding I, Wang J, Lamaziere A, Poirot M et al. (2017). Molecular mediators of mammographic density. CANCER RESEARCH. Conference: 2016 San Antonio Breast Cancer Symposium from: 06/12/2016 to: 10/12/2016, vol. 77,

Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al.(2016). Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. LEUKEMIA vol. 30, (11) 2179-2186.

Proby CM, Inman G, Wang JA, Nagano A, Purdie KJ, Gulati A, Lambert S, Mladkova N et al. (2016). Characterisation of the molecular landscape of cutaneous squamous cell carcinoma and Identification of a novel mutational signature associated with chronic azathioprine exposure. BRITISH JOURNAL OF DERMATOLOGY. vol. 175, 58-59.

Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al.(2016). Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications vol. 7, 12493-12493.

Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al.(2016). Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1. Cell Reports vol. 16, (6) 1604-1613.

Proby C, Inman G, Wang J, Nagano A, Purdie K, Mladkova N, Lambert S, Gulati A et al. (2016). Characterisation of the molecular landscape of cutaneous squamous cell carcinoma. MELANOMA RESEARCH. vol. 26, E69-E69.

Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, Ridgway R, Mchugh A et al. (2016). Frequent loss of function mutations in TGF beta R1 and TGF beta R2 implicate hair follicle bulge stem cells as a cell of origin of cutaneous squamous cell carcinoma. MELANOMA RESEARCH. vol. 26, E63-E64.

Inman G, Proby CM, Wang JA, Nagano A, Alexandrov L, Purdie K, Rose A, Weir L et al. (2016). Identification of a novel mutational signature in cutaneous SCC associated with chronic azathioprine exposure. MELANOMA RESEARCH. vol. 26, E114-E115.

GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al.(2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. Cancer Research

Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al. (2016). GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE. HAEMATOLOGICA. vol. 101, 270-270.

Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al.(2016). Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease. Leukemia vol. 30, (6) 1301-1310.

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al.(2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016). NATURE GENETICS vol. 48, (6) 700-700.

Rio-Machin A, Cardoso S, Tawana K, Wang J, Chelala C, Plagnol V, Wallis Y, Ryan G et al. (2016). WHOLE EXOME SEQUENCING REVEALS NOVEL CANDIDATE GENES IN FAMILIAL MDS/AML. HAEMATOLOGICA. vol. 101, 205-206.

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al.(2016). Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet vol. 48, (6) 700-700.

Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Coates P, Sapkota G, Purdie K et al. (2016). Inactivation of transforming growth factor-beta receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis. BRITISH JOURNAL OF DERMATOLOGY. vol. 174, E51-E52.

Proby C, Inman G, Nagano A, Purdie K, Mladkova N, Alexandrov L, Stratton M, Watt S et al. (2016). The molecular landscape of cutaneous squamous cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 174, E50-E51.

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al.(2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nature Genetics vol. 48, (2) 183-188.

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. (2015). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nature Genetics.

Parry M, Rose-Zerilli MJJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A et al.(2015). Genetics and prognostication in splenic marginal zone lymphoma: Revelations from deep sequencing. Clinical Cancer Research vol. 21, (18) 4174-4183.

Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al.(2015). Disease evolution and outcomes in familial AML with germline CEBPA mutations. Blood vol. 126, (10) 1214-1223.

Tawana K, Wang J, Kiraly PA, Kallay K, Benyo G, Krivan G, Csomor J, Fitzgibbon J et al. (2015). CONVERGENCE OF SOMATIC MUTATIONS WITHIN THE JAK-STAT SIGNALLING PATHWAY IN A NOVEL RUNX1-MUTATED PEDIGREE. HAEMATOLOGICA. vol. 100, 9-10.

Koniali L, Heward J, Loveday C, Wilkins L, Ishfaq M, Wang J, Okosun J, Packham G et al. (2015). KDM5 INHIBITION LEADS TO INCREASED H3K4ME3 LEVELS AND CELL DEATH IN GERMINAL CENTRE LYMPHOMA CELL LINES INDEPENDENT OF MLL2 MUTATION STATUS. HAEMATOLOGICA. vol. 100, 104-104.

Nagano A, Purdie K, Pourreyron C, McHugh A, Xue D, Wright S, Dayal J, Watt S et al. (2015). Cutaneous squamous cell carcinoma cell lines retain the genetic signature of human cutaneous squamous cell carcinoma and recapitulate the histology of the original human tumour in mouse xenograft models. BRITISH JOURNAL OF DERMATOLOGY. vol. 172, E43-E44.

Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y(2015). Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system. Journal of Virology vol. 89, (9) 5176-5179.

Rose-Zerilli MJJ, Parry M, Ljungstrom V, Gibson J, Wang J, Walewska R, Parker H, Parker A et al. (2014). Deep-Sequencing Reveals the Molecular Landscape of Splenic Marginal Zone Lymphoma: Biological and Clinical Implications. BLOOD. vol. 124,

Rose-Zerilli MJ, Jane G, Wang J, Tapper WJ, Parker H, Parker A, Davis Z, Gardiner AC et al. (2014). Tracking Subclonal Mutations in IGHV-Mutated CLL with Progressive Disease. BLOOD. vol. 124,

Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al.(2014). A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Medicine vol. 6, (12)

Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al. (2014). Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY. vol. 165, 16-16.

Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al.(2014). Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia. Blood vol. 123, (13) 2066-2074.

Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al.(2014). Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nature Genetics vol. 46, (2) 176-181.

Okosun J, Bödör C, Wang J, Araf S, Yang C-Y, Pan C, Boller S, Cittaro D et al.(2014). Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat Genet vol. 46, (2) 176-181.

Tawana K, Renneville A, Wang J, Georgiades P, Thomas X, Mialou V, Savic A, Van Delft FW et al. (2013). Familial AML With Germline CEBPA Mutations: Extended Clinical Outcomes and Analysis Of Secondary Mutations Using Whole Exome Sequencing. BLOOD. vol. 122,

Manodoro F, Marzec J, Wang J, Chaplin T, Jovanovic JV, Eva M, Sameena I, Grimwade D et al. (2013). Loss of Imprinting at the 14q32 Domain Leads to MicroRNA Overexpression in Acute Promyelocytic Leukemia. BLOOD. vol. 122,

Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al.(2013). Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology vol. 145, (5) 1121-1132.

Bödör C, Grossmann V, Popov N, Okosun J, O'Riain C, Tan K, Marzec J, Araf S et al.(2013). EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood vol. 122, (18) 3165-3168.

Okosun J, Bödör C, Wang J, Araf S, Chelala C, Fitzgibbon J(2013). Genomic analysis reveals epigenetic ‘addiction’ underpinning follicular lymphoma and its transformation – a rationale for targeted epigenetic therapies. Clinical Epigenetics vol. 5, (S1) Article S10,

Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M et al.(2013). Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol vol. 230, (1) 107-117.

Okosun J, Boedoer C, Wang J, Araf S, Marzec J, Iqbal S, Matthews J, Calaminici M et al. (2012). Whole Genome Sequencing in Sequential Biopsies Reveals the Genetic Evolution of Follicular Lymphoma to Transformed Follicular Lymphoma. BLOOD. vol. 120,

Gilks WR, Welham SJ, Wang J, Clark SJ, King GJ(2012). Three-point appraisal of genetic linkage maps. THEORETICAL AND APPLIED GENETICS vol. 125, (7) 1393-1402.

Manodoro F, Marzec J, Wang J, Chaplin T, Young B, Debernardi S (2012). DEEP SEQUENCING REVEALS ALLELE-SPECIFIC HYPERMETHYLATION AT 14Q32 IMPRINTED DOMAIN IN ACUTE PROMYELOCITIC LEUKAEMIA (APML). HAEMATOLOGICA. vol. 97, 14-14.

Love CG, Andongabo AE, Wang J, Carion PWC, Rawlings CJ, King GJ(2012). InterStoreDB: a generic integration resource for genetic and genomic data. J Integr Plant Biol vol. 54, (5) 345-355.

Wang X, Wang H, Wang J, Sun R, Wu J, Liu S, Bai Y, Mun JH et al.(2011). The genome of the mesopolyploid crop species Brassica rapa. Nature Genetics vol. 43, (10) 1035-1040.

Hammond JP, Mayes S, Bowen HC, Graham NS, Hayden RM, Love CG, Spracklen WP, Wang J et al.(2011). Regulatory Hotspots Are Associated with Plant Gene Expression under Varying Soil Phosphorus Supply in Brassica rapa. PLANT PHYSIOL vol. 156, (3) 1230-1241.

Wang J, Lydiate DJ, Parkin IAP, Falentin C, Delourme R, Carion PWC, King GJ(2011). Integration of linkage maps for the Amphidiploid Brassica napus and comparative mapping with Arabidopsis and Brassica rapa. BMC GENOMICS vol. 12, Article 101,

Wang J, Keightley PD, Halligan DL(2007). Effect of divergence time and recombination rate on molecular evolution of Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites. Journal of Molecular Evolution vol. 65, (6) 627-639.

Wang J, Keightley PD, Johnson T(2006). MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution. BMC Bioinformatics vol. 7,