Publications: Dr Jun Wang

Maldonado H, Dreger M, Bedgood LD, Kyriakou T, Wolanska KI, Rigby ME, Marotta VE, Webster JM et al. ( 2024 ) . A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance . Science Advances vol. 10 , ( 49 )

Elorbany S, Berlato C, Carnevalli LS, Maniati E, Barry ST, Wang J, Manchanda R, Kzhyshkowska J et al. ( 2024 ) . Immunotherapy that improves response to chemotherapy in high-grade serous ovarian cancer . Nature Communications vol. 15 , ( 1 )

Jiang G, Wang Z, Cheng Z, Wang W, Lu S, Zhang Z, Anene CA, Khan F et al. ( 2024 ) . The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma . Nature Communications vol. 15 , ( 1 )

Kumar EA, Korfi K, Bewicke‐Copley F, Close K, Heward J, Witzig T, Leukam M, Ansell S et al. ( 2024 ) . CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma . British Journal of Haematology vol. 205 , ( 5 ) 1804 - 1809 .

Constantinou M, Nicholson J, Zhang X, Maniati E, Lucchini S, Rosser G, Vinel C, Wang J et al. ( 2024 ) . Lineage specification in glioblastoma is regulated by METTL7B . Cell Reports vol. 43 , ( 6 )

Njegić A, Laid L, Zi M, Maniati E, Wang J, Chelu A, Wisniewski L, Hunter J et al. ( 2024 ) . Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice . Journal of Molecular and Cellular Cardiology Plus vol. 8 ,

Zheng J, Bewicke-Copley F, Vermeulen C, Casado P, Kaya F, Demeulemeester J, Guscott M, Krizsán S et al. ( 2023 ) . Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML . Blood vol. 142 , ( Supplement 1 )

Kaya F, Bewicke-Copley F, Izquierdo PC, Zheng J, Miettinen JJ, Khan N, Krizsán S, Saad JJ et al. ( 2023 ) . The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients . Blood vol. 142 , ( Supplement 1 )

Wang J, Harwood C, Bailey E, Bewicke-Copley F, Anene C, Thomson J, Qamar M, Nourse C et al. ( 2023 ) . LB1663 A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis . Journal of Investigative Dermatology vol. 143 , ( 9 )

Bailey P, Ridgway RA, Cammareri P, Treanor-Taylor M, Bailey U-M, Schoenherr C, Bone M, Schreyer D et al. ( 2023 ) . Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression . Nature Communications vol. 14 , ( 1 )

Baleeiro RB, Liu P, Dunmall LSC, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer . Journal for ImmunoTherapy of Cancer vol. 11 , ( 8 )

Wang J, Harwood CA, Bailey E, Bewicke-Copley F, Anene CA, Thomson J, Qamar MJ, Laban R et al. ( 2023 ) . Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis . Journal of the American Academy of Dermatology vol. 89 , ( 6 ) 1159 - 1166 .

Thomson J, Harwoood C, Strid J, Healy E, Wang J ( 2023 ) . O02 Neoantigens from actinic keratosis are predicted to be more immunogenic than those from cutaneous squamous cell carcinoma – a strategy for immune escape? . British Journal of Dermatology vol. 189 , ( 1 ) e4 - e5 .

Peleva E, Chen Y, Rizvi H, Harwood C, Wang J ( 2023 ) . 010 Enhanced outcome prediction in cutaneous squamous cell carcinoma using deep-learning and computational histopathology (cSCCnet) . British Journal of Dermatology vol. 188 , ( Supplement_4 )

Thomson J, Healy E, Strid J, Harwood C, Wang J ( 2023 ) . 274 Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype . Journal of Investigative Dermatology vol. 143 , ( 5 )

Philippe C, Mian S, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al. ( 2023 ) . O20 TARGETING THE DEFECTIVE COA PATHWAY TO IMPROVE ERYTHROPOIESIS IN SF3B1-MUTANT MDS-RS PATIENTS . Leukemia Research vol. 128 ,

Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S et al. ( 2023 ) . Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma . Blood Advances vol. 7 , ( 5 ) 845 - 855 .

Rozowsky J, Gao J, Borsari B, Yang YT, Galeev T, Gürsoy G, Epstein CB, Xiong K et al. ( 2023 ) . The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models . Cell vol. 186 , ( 7 ) 1493 - 1511.e40 .

Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al. ( 2023 ) . Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia . Science Translational Medicine vol. 15 , ( 685 ) eabn5135 - eabn5135 .

Knight CH, Khan F, Patel A, Gill US, Okosun J, Wang J ( 2023 ) . IBRAP: integrated benchmarking single-cell RNA-sequencing analytical pipeline . Briefings in Bioinformatics vol. 24 , ( 2 )

Wang J, Harwood C, Bailey E, Bewicke-Copley F, Anene C, Thomson J, Qamar M, Nourse C et al. ( 2023 ) . A multi-gene prognostic signature associated with cutaneous squamous cell carcinoma metastasis . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , B8 - B8 .

Baleeiro R, Liu P, Chard LS, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Emerging Data from the Use of TILT-123, an Oncolytic Adenovirus Armed with TNFa and IL-2 in Patients with Solid Tumors . MOLECULAR THERAPY . vol. 31 , 154 - 154 .

Thomson J, Healy E, Strid J, Harwood C, Wang J ( 2023 ) . Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S47 - S47 .

Rio-Machin A, Bewicke-Copley F, Zheng J, Izquierdo PC, Miettinen JJ, Khan N, Demeulemeester J, Krizsán S et al. ( 2022 ) . Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML . Blood vol. 140 , ( Supplement 1 ) 1030 - 1032 .

Perrett M, Pickard L, Kumar E, Palladino G, Khan F, Edmondson C, Knight C, Poynton E et al. ( 2022 ) . Longitudinal Single Cell Analyses Reveal the Co-Evolutionary Dynamics of the Tumor and Microenvironment Accompanying Follicular Lymphoma Transformation . Blood vol. 140 , ( Supplement 1 ) 748 - 749 .

Shaikh N, Mazzagatti A, De Angelis S, Johnson SC, Bakker B, Spierings DCJ, Wardenaar R, Maniati E et al. ( 2022 ) . Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses . Genome Biology vol. 23 , ( 1 )

Armes H, Bewicke‐Copley F, Rio‐Machin A, Di Bella D, Philippe C, Wozniak A, Tummala H, Wang J et al. ( 2022 ) . Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment . British Journal of Haematology vol. 199 , ( 5 ) 754 - 764 .

D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B et al. ( 2022 ) . ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning . Development vol. 149 , ( 13 )

Wang Z, Cheng Z, Lu S, Dunmall LSC, Wang J, Guo Y, Wang Y ( 2022 ) . Characterization of the Intra-tumoral B Cell Immunoglobulin Repertoire Is of Prognostic Value for Esophageal Squamous Cell Carcinoma . Frontiers in Immunology vol. 13 ,

Anene CA, Taggart E, Harwood CA, Pennington DJ, Wang J ( 2022 ) . Decosus: An R Framework for Universal Integration of Cell Proportion Estimation Methods . Frontiers in Genetics vol. 13 ,

Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 )

Walne AJ, Vulliamy T, Bewicke-Copley F, Wang J, Alnajar J, Bridger MG, Ma B, Tummala H et al. ( 2021 ) . Genome-wide whole-blood transcriptome profiling across inherited bone marrow failure subtypes . Blood Advances vol. 5 , ( 23 ) 5360 - 5371 .

Mian S, Philippe C, Maniati E, Bergot T, Piganeau M, Di Bella D, Morales V, Finch A et al. ( 2021 ) . Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia . Blood vol. 138 , ( Supplement 1 )

Keane L, Antignano I, Riechers S-P, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J et al. ( 2021 ) . mTOR-dependent translation amplifies microglia priming in aging mice . Journal of Clinical Investigation vol. 131 , ( 20 )

Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B et al. ( 2021 ) . Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections . Science Advances vol. 7 , ( 37 )

Anene CA, Khan F, Bewicke-Copley F, Maniati E, Wang J ( 2021 ) . ACSNI: An unsupervised machine-learning tool for prediction of tissue-specific pathway components using gene expression profiles . Patterns vol. 2 , ( 6 ) Article 100270 , 100270 - 100270 .

Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al. ( 2021 ) . Correction to ‘Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma’ . NAR Cancer vol. 3 , ( 2 )

Heward J, Konali L, D'Avola A, Close K, Yeomans A, Philpott M, Dunford J, Rahim T et al. ( 2021 ) . KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas . Blood vol. 138 , ( 5 ) 370 - 381 .

Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al. ( 2021 ) . Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma . NAR Cancer vol. 3 , ( 1 )

Tse WY, Maniati E, Wang J, Lockley M, Martin S . Identification of a novel regulator of FANCD2 mediated DNA Repair . Conference: Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response

Thomson J, Bewicke-Copley F, Anene CA, Gulati A, Nagano A, Purdie K, Inman GJ, Proby CM et al. ( 2021 ) . The Genomic Landscape of Actinic Keratosis . Journal of Investigative Dermatology vol. 141 , ( 7 ) 1664 - 1674.e7 .

Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al. ( 2021 ) . The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis . Cancers vol. 13 , ( 2 )

Larrea E, Fernandez-Mercado M, Guerra-Assunção JA, Wang J, Goicoechea I, Gaafar A, Ceberio I, Lobo C et al. ( 2020 ) . Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma . International Journal of Molecular Sciences vol. 21 , ( 22 )

Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al. ( 2020 ) . Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia . Blood vol. 136 , ( Supplement 1 ) 39 - 40 .

Uyulur F, Bewicke-Copley F, Anene CA, Schlesner M, Project IM-S, Siebert R, Okosun J, Fitzgibbon J et al. ( 2020 ) . Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma . Blood vol. 136 , ( Supplement 1 ) 26 - 27 .

Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D et al. ( 2020 ) . Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma . Cancer Research

Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 )

Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . NPJ Breast Cancer vol. 6 , ( 1 )

Iacovazzo D, Thong LC, Quezado R, Drummond J, Antonio DSBF, Cuenco J, Brändle M, Walker E et al. ( 2020 ) . The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators . Endocrine Abstracts

Dokal I, Tummala H, Vulliamy T, Walne A ( 2020 ) . A frameshift variant in the specificity protein 1 triggers superactivation of SP1-mediated transcription in familial bone marrow failure . Proceedings of the National Academy of Sciences of USA Article 32636268 ,

Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K ( 2020 ) . Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance . Cancer Research . vol. 80 , a31 - a31 .

Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al. ( 2020 ) . Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma . Haematologica vol. 105 , ( 6 ) 318 - 321 .

Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al. ( 2020 ) . Cancer associated fibroblast FAK regulates malignant cell metabolism . Nature Communications vol. 11 , ( 1 ) 1290 - 1290 .

Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N et al. ( 2020 ) . The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants . Nature Communications vol. 11 , ( 1 )

Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .

Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K ( 2020 ) . Tumor stroma in the development of acquired cancer therapy resistance . CANCER RESEARCH . vol. 80 , 48 - 48 .

Bewicke-Copley F, Korfi K, Araf S, Kumar EA, Cummin TEC, Ashton-Key M, Barrans S, Van Hoppe S et al. ( 2019 ) . Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel . Blood vol. 134 , ( Supplement_1 )

Bewicke-Copley F, Kumar EA, Palladino G, Korfi K, Wang J ( 2019 ) . Applications and analysis of targeted genomic sequencing in cancer studies . Computational and Structural Biotechnology Journal vol. 17 , 1348 - 1359 .

Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease . The Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .

Brown P, Tan A-C, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF, Cernava T et al. ( 2019 ) . Large expert-curated database for benchmarking document similarity detection in biomedical literature search . Database vol. 2019 ,

Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .

Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al. ( 2019 ) . 423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer . Journal of Investigative Dermatology . vol. 139 ,

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al. ( 2019 ) . A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing . International Journal of Molecular Sciences vol. 20 , ( 14 )

Kumar E, Korfi K, Bewicke‐Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al. ( 2019 ) . PF513 MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA . HemaSphere vol. 3 , ( S1 )

Korfi K, Araf S, Bewicke‐Copley F, Kumar E, Cummin T, Ashton‐Key M, Barrans S, Van Hoppe S et al. ( 2019 ) . LONGITUDINAL ANALYSES OF DIAGNOSTIC‐RELAPSE BIOPSIES OF DIFFUSE LARGE B CELL LYMPHOMA SUGGEST THAT RELAPSE IS MEDIATED BY DISTINCT MECHANISMS IN ABC AND GCB LYMPHOMA . Hematological Oncology vol. 37 , ( S2 ) 142 - 143 .

Kumar E, Korfi K, Bewicke-Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al. ( 2019 ) . MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA . HemaSphere vol. 3 ,

Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . 454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . Journal of Investigative Dermatology vol. 139 , ( 5 )

Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al. ( 2019 ) . Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant . Haematologica vol. 104 , ( 4 ) e174 - e177 .

Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 33 , ( 6 ) 1540 - 1540 .

Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al. ( 2019 ) . Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma . Journal of Investigative Dermatology vol. 139 , ( 8 ) 1658 - 1671.e8 .

Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 139 , S78 - S78 .

Patel MB, Wang J ( 2018 ) . The Identification and Interpretation of cis-Regulatory Noncoding Mutations in Cancer . BioTech vol. 8 , ( 1 )

Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al. ( 2018 ) . The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Nature Communications vol. 9 , ( 1 )

Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O’Toole EA et al. ( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 )

Ullah AZD, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) w109 - w113 .

Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A et al. ( 2018 ) . CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype . Cell Reports vol. 23 , ( 5 ) 1448 - 1460 .

Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S et al. ( 2018 ) . GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML . Leukemia vol. 32 , ( 11 ) 2502 - 2507 .

Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al. ( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .

Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1261 - 1265 .

Wang J, Ullah AZD, Chelala C ( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome . Nucleic Acids Research vol. 46 , ( 8 ) e47 - e47 .

Al Seraihi AF, Rio-Machin A, Tawana K, Bodor C, Wang J, Nagano A, Heward JA, Iqbal S et al. ( 2018 ) . <i>GATA2</i> monoallelic expression underlies reduced penetrance in inherited <i>GATA2</i>-mutated MDS/AML . LEUKEMIA vol. 32 , ( 11 ) 2502 - 2507 .

Thomson J, Proby C, Leigh I, Nagano A, Harwood C, Inmann G, Wang J ( 2018 ) . Exome sequencing of a cohort of actinic keratoses to identify significantly mutated genes . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E400 - E400 .

Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2017 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discov

Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J et al. ( 2017 ) . Lamin B1 regulates somatic mutations and progression of B-cell malignancies . Leukemia vol. 32 , ( 2 ) 364 - 375 .

Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform

Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M ( 2017 ) . Abstract 5558: Deconstruction of a human tumor microenvironment . Cancer Research . vol. 77 , 5558 - 5558 .

Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Wang J, Fischer K, Akylzhanova G, Edelmann J et al. ( 2017 ) . NUCLEAR LAMINA REGULATES SOMATIC HYPERMUTATION AND PROGRESSION OF B CELL MALIGNANCIES . HAEMATOLOGICA . Conference: EHA vol. 102 , 228 - 228 .

Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 )

Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al. ( 2017 ) . Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree . European Journal of Human Genetics vol. 25 , ( 8 ) 1020 - 1024 .

Ironside A, Hawkesford K, Gomm J, Haywood L, Goulding I, Wang J, Lamaziere A, Poirot M et al. ( 2017 ) . Molecular mediators of mammographic density . CANCER RESEARCH . Conference: 2016 San Antonio Breast Cancer Symposium from: 06/12/2016 to: 10/12/2016 , vol. 77 ,

Harwood C, Proby C, Wang J, Nagano A, Alexandrov L, Purdie K, Chelala C, Inman G et al. ( 2017 ) . Chronic azathioprine treatment is causal in cutaneous squamous cell carcinoma development and is associated with a novel mutational signature . BRITISH JOURNAL OF DERMATOLOGY . vol. 177 , 9 - 10 .

Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward JA et al. ( 2017 ) . Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma . BLOOD . vol. 130 ,

Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . LEUKEMIA vol. 30 , ( 11 ) 2179 - 2186 .

Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al. ( 2016 ) . Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Nature Communications vol. 7 , 12493 - 12493 .

Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al. ( 2016 ) . Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 . Cell Reports vol. 16 , ( 6 ) 1604 - 1613 .

Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . Leukemia

GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016) . NATURE GENETICS vol. 48 , ( 6 ) 700 - 700 .

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al. ( 2016 ) . Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nat Genet vol. 48 , ( 6 ) 700 - 700 .

Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al. ( 2016 ) . Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease . Leukemia vol. 30 , ( 6 ) 1301 - 1310 .

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics vol. 48 , ( 2 ) 183 - 188 .

Proby C, Inman G, Wang J, Nagano A, Purdie K, Mladkova N, Lambert S, Gulati A et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma . MELANOMA RESEARCH . vol. 26 , E69 - E69 .

Proby CM, Inman G, Wang JA, Nagano A, Purdie KJ, Gulati A, Lambert S, Mladkova N et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma and Identification of a novel mutational signature associated with chronic azathioprine exposure . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 58 - 59 .

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