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Publications:  Prof Adrian Hobbs

Armstrong P, Ferreira PM, Chan M, Lundberg Slingsby M, Crescente M, Shih C, Kirkby N, Hobbs A et al.(2020). Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy. Journal of Thrombosis and Haemostasis
10.1111/jth.14826
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64692
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al.(2020). C-type natriuretic peptide co-ordinates cardiac structure and function. European Heart Journal vol. 41, (9) 1006-1020.
10.1093/eurheartj/ehz093
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56755
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.(2019). Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. Journal of Pathology vol. 249, (4) 523-535.
10.1002/path.5340
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59784
Perez-Ternero C, Aubdool AA, Moyes AJ, Hobbs AJ (2019). C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling. CIRCULATION. vol. 140,
Hobbs AJ(2019). Nitric oxide biology & pathobiology (3rd edition) editors: Louis Ignarro & Bruce Freeman. Nitric Oxide vol. 90,
10.1016/j.niox.2018.10.005
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60018
Preedy MEJ, Baliga R, Dukinfield M, Chu S, Aubdool A, Bubb K, Moyes A, Tones M et al. (2019). Phosphodiesterase 2 promotes nitric oxide/guanylyl cyclase/cGMP signalling in heart failure. JOURNAL OF TRANSLATIONAL MEDICINE. vol. 17,
Preedy ME, Baliga RS, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. (2019). Inhibition of phosphodiesterase 2 reverses the development of heart failure by promoting NO/guanylyl cyclase/cGMP signalling. BRITISH JOURNAL OF PHARMACOLOGY. vol. 176, 3008-3009.
Preedy MEJ, Baliga RS, Hobbs AJ(2019). Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure. Journal of Cardiovascular Pharmacology
10.1097/FJC.0000000000000724
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61998
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A, Stasch J-P(2019). Correction to: Soluble Guanylate Cyclase Stimulators and Activators. Handbook of Experimental Pharmacology
10.1007/164_2019_249
https://qmro.qmul.ac.uk/xmlui/handle/123456789/60543
Conole D, Myers SH, Mota F, Hobbs AJ, Selwood DL(2019). Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands. Chem Biol Drug Des vol. 93, (6) 1011-1020.
10.1111/cbdd.13395
https://qmro.qmul.ac.uk/xmlui/handle/123456789/45923
Scott TE, Kemp-Harper BK, Hobbs AJ(2019). Inflammasomes: a novel therapeutic target in pulmonary hypertension?. Br J Pharmacol vol. 176, (12) 1880-1896.
10.1111/bph.14375
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42748
Moyes AJ, Hobbs AJ(2019). C-type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature. Int J Mol Sci vol. 20, (9)
10.3390/ijms20092281
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57928
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K et al.(2019). Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial. Br J Pharmacol vol. 176, (9) 1251-1267.
10.1111/bph.14621
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55912
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A, Stasch J-P(2019). Soluble Guanylate Cyclase Stimulators and Activators. Handb Exp Pharmacol
10.1007/164_2018_197
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55792
Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC et al.(2018). Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling. Circulation
10.1161/CIRCULATIONAHA.118.036344
https://qmro.qmul.ac.uk/xmlui/handle/123456789/54649
Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ et al.(2018). Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation. Clinical Pharmacology and Therapeutics vol. 104, (4) 675-686.
10.1002/cpt.980
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42723
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al.(2018). Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure. Proc Natl Acad Sci U S A
10.1073/pnas.1800996115
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42747
Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL et al.(2018). Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology. FEBS Lett vol. 592, (12) 2140-2152.
10.1002/1873-3468.13090
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39087
Barrese V, Stott JB, Figueiredo HB, Aubdool AA, Hobbs AJ, Jepps TA, McNeish AJ, Greenwood IA(2018). Angiotensin II promotes KV7.4 channels degradation through reduced interaction with HSP90 (Heat Shock Protein 90). Hypertension vol. 71, (6) 1091-1100.
10.1161/HYPERTENSIONAHA.118.11116
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42743
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al.(2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Human Molecular Genetics vol. 27, (1) 199-210.
10.1093/hmg/ddx375
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30823
Aubdool AA, Bubb KJ, Moyes AJ, Drayton JP, Mehta V, Zachary IC, Tsui J, Abraham DJ et al. (2017). Endothelium-Derived C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodelling. CIRCULATION. vol. 136,
Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO, Hobbs AJ(2016). Functional pharmacological characterization of SER100 in cardiovascular health and disease. Br J Pharmacol
10.1111/bph.13634
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15911
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. vol. 34 Suppl 2, Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable , Medium: Print,
10.1097/01.hjh.0000491573.57396.0f
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42746
Hobbs AJ(2016). A Janus-Faced Role for Atrial Natriuretic Peptide in Myocardial Infarction?. Circ Res vol. 119, (2) 181-183.
10.1161/CIRCRESAHA.116.309119
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14805
O'Brien A, China L, Massey KA, Nicolaou A, Winstanley A, Newson J, Hobbs A, Audzevich T et al.(2016). Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences. Liver Int vol. 36, (6) 837-846.
10.1111/liv.12876
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14816
Hobbs AJ(2016). Guanylyl cyclase can't stand the HETE. Am J Physiol Heart Circ Physiol vol. 310, (11) H1608-H1610.
10.1152/ajpheart.00326.2016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14808
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N et al.(2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. Journal of the American Society of Nephrology
10.1681/ASN.2015060670
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12841
Moyes AJ, Stanford SC, Hosford PS, Hobbs AJ, Ramage AG(2016). Raised arterial blood pressure in neurokinin-1 receptor-deficient mice ( NK1R −/− ): evidence for a neural rather than a vascular mechanism. Experimental Physiology vol. 101, (5) 588-598.
10.1113/EP085347
Oettrich JM, Dao VT, Frijhoff J, Kleikers PWM, Casas AI, Hobbs AJ, Schmidt HHHW(2016). Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology. CLINICAL PHARMACOLOGY & THERAPEUTICS vol. 99, (4) 360-362.
10.1002/cpt.336
Sand CA, Hobbs AJ(2016). The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer?. Vascul Pharmacol vol. 77, 35-37.
10.1016/j.vph.2015.10.008
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22102
Baliga RS, Moyes AJ, Villar IC, Schaeper U, Iannone L, Hobbs AJ, Pharmacology C (2016). Therapeutic Proof-Of-Concept For Novel Sirna Technology In Experimental Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 193,
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ (2015). Endothelial and Cardiomyocyte-derived C-type Natriuretic Peptide Coordinate Heart Structure and Function. CIRCULATION. vol. 132,
Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ, Chowdhury TT(2015). C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Biochemical and Biophysical Research Communications vol. 465, (4) 784-789.
10.1016/j.bbrc.2015.08.087
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. vol. 29, is. 10, pp. 624-624.
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. (2015). BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. JOURNAL OF HYPERTENSION. vol. 33, E518-E519.
10.1097/01.hjh.0000469025.55363.41
Papapetropoulos A, Hobbs AJ, Topouzis S(2015). Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS. Br J Pharmacol vol. 172, (6) 1397-1414.
10.1111/bph.12980
Peake NJ, Pavlov AM, D'Souza A, Pingguan-Murphy B, Sukhorukov GB, Hobbs AJ, CHOWDHURY TT(2015). Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants. Biomacromolecules
10.1021/bm501575w
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6570
Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P et al.(2014). Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility. Free Radic Biol Med vol. 77, 82-94.
10.1016/j.freeradbiomed.2014.09.007
https://qmro.qmul.ac.uk/xmlui/handle/123456789/7681
Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F, Chowdhury TT(2014). Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function. Osteoarthritis Cartilage vol. 22, (11) 1800-1807.
10.1016/j.joca.2014.07.018
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al.(2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest vol. 124, (9) 4039-4051.
10.1172/JCI74281
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6288
Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ, Hobbs AJ(2014). Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension. Circulation vol. 130, (6) 496-507.
10.1161/CIRCULATIONAHA.114.009751
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ(2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol vol. 171, (14) 3463-3475.
10.1111/bph.12694
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14814
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al. (2014). Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo model. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95, A27-A27.
Gonzales MA, Han H, Moyes A, Radinos A, Hobbs AJ, Coombs N, Oliver SRJ, Mascharak PK(2014). Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex. JOURNAL OF MATERIALS CHEMISTRY B vol. 2, (15) 2107-2113.
10.1039/c3tb21309a
Hobbs AJ(2014). Natriuretic peptide receptors and heart failure: to B or not to B blocked?. Naunyn Schmiedebergs Arch Pharmacol vol. 387, (1) 1-4.
10.1007/s00210-013-0946-0
Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ et al.(2013). Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum vol. 65, (11) 2928-2939.
10.1002/art.38078
Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M et al.(2013). C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling. CIRCULATION RESEARCH vol. 112, (10) 1355-+.
10.1161/CIRCRESAHA.113.301325
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S et al.(2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension vol. 61, (5) 1091-1102.
10.1161/HYPERTENSIONAHA.111.00933
Ahluwalia A, Hobbs AJ(2013). Letter by Ahluwalia and Hobbs Regarding Article, "Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics". CIRCULATION vol. 127, (2) E275-E275.
10.1161/CIRCULATIONAHA.112.118356
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al.(2013). Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor model. Arthritis Research and Therapy vol. 15, (4)
10.1186/ar4253
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6631
Bubb KJ, Trinder S, Baliga R, MacAllister RJ, Hobbs AJ (2013). Validation Of Phosphodiesterase 2 As A Novel Therapeutic Target In Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 187,
Baliga RS, Macallister RJ, Hobbs AJ(2013). Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application. Handb Exp Pharmacol vol. 218, 477-511.
10.1007/978-3-642-38664-0_19
Moyes AJ, Khambata RS, Ahluwalia A, Hobbs AJ(2012). Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide. CIRCULATION vol. 126, (21)
Chan MV, Bubb KJ, Noyce A, Villar IC, Duchene J, Hobbs AJ, Scotland RS, Ahluwalia A(2012). Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation. Br J Pharmacol vol. 167, (4) 805-817.
10.1111/j.1476-5381.2012.02012.x
Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A, Hobbs AJ(2012). Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Circulation vol. 125, (23) 2922-2932.
10.1161/CIRCULATIONAHA.112.100586
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham D, Denton C (2012). SYSTEMIC VEGF INHIBITION INDUCES PULMONARY ARTERIAL HYPERTENSION IN A TRANSGENIC MOUSE MODEL OF SCLERODERMA. RHEUMATOLOGY. vol. 51, 41-41.
Gonzalez MA, Yim MA, Cheng S, Moyes A, Hobbs AJ, Mascharak PK(2012). Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules. INORGANIC CHEMISTRY vol. 51, (1) 601-608.
10.1021/ic2021287
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham DJ, Denton CP (2011). Intermittent Systemic VEGF Inhibition Induces Pulmonary Arterial Hypertension In a Transgenic Mouse Model of Scleroderma. ARTHRITIS AND RHEUMATISM. vol. 63, S1022-S1023.
Khambata RS, Panayiotou CM, Hobbs AJ(2011). Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide. Br J Pharmacol vol. 164, (2b) 584-597.
10.1111/j.1476-5381.2011.01400.x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14813
Pourcet B, Feig JE, Vengrenyuk Y, Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA et al.(2011). LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res vol. 109, (5) 492-501.
10.1161/CIRCRESAHA.111.241810
Velmurugan S, Kapil V, McKnight AHO, Aboud Z, Davies S, Milsom AB, Pearl V, Liverani E et al. (2011). Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 24, S35-S36.
10.1016/j.niox.2011.03.285
Baliga RS, MacAllister RJ, Hobbs AJ(2011). New perspectives for the treatment of pulmonary hypertension. Br J Pharmacol vol. 163, (1) 125-140.
10.1111/j.1476-5381.2010.01164.x
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al.(2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol vol. 31, (5) 1075-1083.
10.1161/ATVBAHA.111.223545
Gonzalez MA, Fry NL, Burt R, Davda R, Hobbs A, Mascharak PK(2011). Designed Iron Carbonyls as Carbon Monoxide (CO) Releasing Molecules: Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta. INORG CHEM vol. 50, (7) 3127-3134.
10.1021/ic2000848
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton C (2011). AN EXPLORATION OF PULMONARY VASCULAR VEGF SIGNALLING IN A TGF beta-DEPENDENT MOUSE MODEL OF SYSTEMIC SCLEROSIS. RHEUMATOLOGY. vol. 50, 134-135.
Kapil V, Benjamin N, Hobbs A, Ahluwalia A(2011). Response to Inorganic Nitrate for Blood Pressure Lowering?. HYPERTENSION vol. 57, (2) E3-E3.
10.1161/HYPERTENSIONAHA.110.164814
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2011). Protective Role Of Natriuretic Peptides In Pulmonary Fibrosis: A Novel Therapeutic Target?. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 183,
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton CP(2010). Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis. CLIN EXP RHEUMATOL vol. 28, (5) S63-S63.
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al.(2010). Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. AM J PHYSIOL-HEART C vol. 299, (3) H827-H836.
10.1152/ajpheart.00129.2010
Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V et al.(2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension vol. 56, (2) 274-281.
10.1161/HYPERTENSIONAHA.110.153536
Kapil V, Maleki-Toyserkani S, Rehman F, Arghandawi S, Pearl V, Milsom A, Benjamin N, Hobbs A et al. (2010). Oral inorganic nitrate lowers blood pressure in healthy male, but not female, volunteers, via bioconversion to nitrite. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. vol. 70, 285-285.
Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M, Hobbs AJ(2010). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. Br J Pharmacol vol. 160, (8) 2045-2054.
10.1111/j.1476-5381.2010.00830.x
Khambata RS, Panayiotou CM, Xiao F, Hobbs AJ(2010). The anti-atherogenic potential of C-type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor-C. FASEB JOURNAL vol. 24,
Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ et al.(2010). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. NITRIC OXIDE-BIOL CH vol. 22, (2) 141-148.
10.1016/j.niox.2009.10.010
Lumsden NG, Khambata RS, Hobbs AJ(2010). C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target. CURR PHARM DESIGN vol. 16, (37) 4080-4088.
Lumsden NG, Khambata RS, Hobbs AJ(2010). C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target. Curr Pharm Des vol. 16, (37) 4080-4088.
10.2174/138161210794519237
Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al.(2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol vol. 29, (11) 1757-1763.
10.1161/ATVBAHA.109.191775
Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB, Hobbs AJ, Miranda KM et al.(2009). The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS. J BIOL CHEM vol. 284, (33) 21788-21796.
10.1074/jbc.M109.014282
Kapil V, Rehman F, Arghandawi S, Milsom A, Benjamin N, Hobbs A, MacAllister R, Webb A et al.(2009). BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE. BASIC CLIN PHARMACOL vol. 105, 31-31.
Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G et al.(2009). Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans. J IMMUNOL vol. 183, (3) 2089-2096.
10.4049/jimmunol.0900477
Okorie M, Akram F, Loukogeorgakis S, Webb A, Deanfield J, Benjamin N, Hobbs A, MacAllister R et al.(2009). ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS. BASIC CLIN PHARMACOL vol. 105, 26-26.
Kapil V, Okorie M, Akram F, Rehman F, Milsom A, Arghandawi S, Pearl V, Deanfield J et al. (2009). Oral inorganic nitrate lowers blood pressure and protects against endothelial ischaemia-reperfusion injury in humans. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 20, S37-S37.
Milsom A, Patel N, Storey A, Cuzzocrea S, Mazzon E, Webb A, Hobbs A, Thiemermann C et al. (2009). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischaemia-reperfusion injury in mice. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 20, S39-S40.
10.1016/j.niox.2009.10.010
Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, Villar I, Worthington R et al.(2009). Design and development of novel non-peptide agonists at natriuretic peptide receptor-C. FASEB JOURNAL vol. 23,
Hajihosseini MK, Ramasamy S, De Langhe S, Lana-Elola E, Rice D, Rio LQ, Kelly R, Sharpe J et al.(2009). Involvement of Fibroblast growth factor 10 (Fgf10) in the anterior-posterior patterning and specification of muscle and tendon progenitors in the developing mouse limbs. FASEB JOURNAL vol. 23,
Diller GP, Bedard E, Wort SJ, Gatzoulis MA, van Eijl S, Ali O, Wilkins MR, Wharton J et al.(2009). Response to Letter Regarding Article, "Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension". CIRCULATION vol. 119, (9) E231-E231.
10.1161/CIRCULATIONAHA.108.816363
Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D et al.(2008). Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res vol. 103, (9) 957-964.
10.1161/CIRCRESAHA.108.175810
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ et al.(2008). Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. Am J Respir Crit Care Med vol. 178, (8) 861-869.
10.1164/rccm.200801-121OC
Marro ML, Peiro C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW, Hobbs AJ(2008). Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor. J BIOL CHEM vol. 283, (29) 20027-20036.
10.1074/jbc.M801223200
Diller GP, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bedard E et al.(2008). Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. CIRCULATION vol. 117, (23) 3020-3030.
10.1161/CIRCULATIONAHA.108.769646
Chan MV, Hobbs AJ, Scotland RS, Ahluwalia A (2008). Nitric oxide-induced relaxation in female resistance arteries is endothelium-dependent. BASIC CLIN PHARMACOL. vol. 102, 38-38.
Villar IC, Hobbs AJ, Ahluwalia A(2008). Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. J ENDOCRINOL vol. 197, (3) 447-462.
10.1677/JOE-08-0070
Aboud Z, Misra S, Warner T, Miall P, Benjamin N, Hobbs A, Webb A, Ahluwalia A (2008). The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. vol. 65, 999-999.
Morton J, Coles B, Wright K, Gallimore A, Morrow JD, Terry ES, Anning PB, Morgan BP et al.(2008). Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN gamma-dependent iNOS expression in the vasculature of healthy mice. BLOOD vol. 111, (10) 5187-5194.
10.1182/blood-2007-10-117283
Webb A, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P et al.(2008). Acute blood pressure lowering and vasoprotective effects of dietary nitrate. FASEB JOURNAL vol. 22,
Panayiotou CM, Stidwill R, Taylor V, Singer M, Hobbs AJ(2008). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. FASEB JOURNAL vol. 22,
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P et al.(2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. HYPERTENSION vol. 51, (3) 784-790.
10.1161/HYPERTENSIONAHA.107.103523
Milsom AB, Hobbs AJ, Ahluwalia A (2008). Endothelial nitric oxide synthase acts as a nitrite reductase in human endotheliall cells. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 19, S51-S52.
10.1016/j.niox.2008.06.134
Baliga R, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ (2007). Selective modulation of ANP-dependent dilation in the pulmonary vasculature by PDE 5 inhibitors: A novel combination therapy for pulmonary hypertension?. CIRCULATION. vol. 116, 456-456.
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Rashid R, Deanfield J, Benjamin N, MacAllister R et al. (2007). Acute blood pressure (BP) lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate. J HUM HYPERTENS. vol. 21, 834-835.
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Rashid R, Deanfield J, Benjamin N, Macallister R et al. (2007). Acute blood pressure lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate. EUROPEAN HEART JOURNAL. vol. 28, 865-866.
Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B, Ahluwalia A et al.(2007). Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. CARDIOVASC RES vol. 74, (3) 515-525.
10.1016/j.cardiores.2007.02.032
Paolocci N, Jackson MI, Lopez BE, Miranda K, Tocchetti CG, Wink DA, Hobbs AJ, Fukuto JM(2007). The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO. PHARMACOLOGY & THERAPEUTICS vol. 113, (2) 442-458.
10.1016/j.pharmthera.2006.11.002
Madhani M, Patra AK, Miller TW, Eroy-Reveles AA, Hobbs AJ, Fukuto JM, Mascharak PK(2006). Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta. J Med Chem vol. 49, (25) 7325-7330.
10.1021/jm0604629
Madhani M, Okorie M, Hobbs AJ, MacAllister RJ(2006). Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo. Br J Pharmacol vol. 149, (6) 797-801.
10.1038/sj.bjp.0706920
Villar IC, Ahluwalia A, Hobbs AJ(2006). Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries. ACTA PHARMACOL SIN vol. 27, (9) 1276-1276.
Villar IC, Francis S, Webb A, Hobbs AJ, Ahluwalia A(2006). Novel aspects of endothelium-dependent regulation of vascular tone. KIDNEY INT vol. 70, (5) 840-853.
10.1038/sj.ki.5001680
Panayiotou CM, Hobbs AJ(2006). C-Type natriuretic peptide mediates ERK1/2 phosphorylation via Gi-coupled natriuretic peptide receptor-C in rat aortic smooth muscle cells. ACTA PHARMACOL SIN vol. 27, 170-170.
Marro M, Panayiotou C, Hobbs A(2006). Vascular inflammation modulates alpha 1 and beta 1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells (HASMCs). ACTA PHARMACOL SIN vol. 27, 172-172.
Miller TW, Franco NE, Hobbs AJ, Ignarro LJ, Fukuto JM (2006). Effect of changing redox status on the activation of soluble guanylate cyclase by nitrogen oxides. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 14, A38-A38.
10.1016/j.niox.2006.04.129
Scotland RS, Duchene J, Hobbs A, Ahluwalia A (2006). Gender-differences in leukocyte activation in vivo: role of endothelium-derived mediators. FASEB JOURNAL. vol. 20, A1193-A1193.
Scotland RS, Cohen M, Foster P, Lovell M, Mathur A, Ahluwalia A, Hobbs AJ(2005). C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. P NATL ACAD SCI USA vol. 102, (40) 14452-14457.
10.1073/pnas.0504961102
Connelly L, Madhani M, Hobbs AJ(2005). Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem vol. 280, (11) 10040-10046.
10.1074/jbc.M411991200
Ahluwalia A, Villar I, Scotland RS, Hobbs A (2005). The natriuretic peptide receptor-C antagonist, M372049, blocks C-type natriuretic peptide and endothelium-derived hyperpolarizing factor-induced relaxation of resistance arteries. FASEB JOURNAL. vol. 19, A1556-A1556.
Ahluwalia A, Hobbs AJ(2005). Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor. TRENDS PHARMACOL SCI vol. 26, (3) 162-167.
10.1016/j.tips.2005.01.005
Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A(2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. CIRCULATION vol. 111, (6) 796-803.
10.1161/01.CIR.0000155238.70797.4E
Scotland RS, Ahluwalia A, Hobbs AJ(2005). C-type natniuretic peptide in vascular physiology and disease. PHARMACOL THERAPEUT vol. 105, (2) 85-93.
10.1016/j.pharmthera.2004.08.011
Scotland R, Foster P, Ahluwalia A, Hobbs AJ (2004). C-type natriuretic peptide inhibits leukocyte recruitment in vivo via natriuretic peptide receptor-C activation. CIRCULATION. vol. 110, 240-240.
Ahluwalia A, Foster P, Prescott C, Hobbs AJ (2004). Endothelial C-type natriuretic peptide regulates coronary blood flow and prevents ischemia-reperfusion injury. CIRCULATION. vol. 110, 77-77.
Chauhan SD, Hobbs AJ, Ahluwalia A(2004). C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor. Int J Biochem Cell Biol vol. 36, (10) 1878-1881.
10.1016/j.biocel.2003.09.009
Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A(2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide. CIRCULATION vol. 110, (10) 1231-1235.
10.1161/01.CIR.0000141802.29945.34
Connelly L, Hobbs AJ (2004). Endothelial nitric oxide synthase promotes inducible NOS expression in LPS-challenged mice in vivo. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 11, 122-122.
Madhani M, MacAllister RJ, Hobbs AJ (2004). Reciprocal interaction between soluble and particulate guanylate cyclases in vivo. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 11, 120-120.
Ahluwalia A, MacAllister RJ, Hobbs AJ(2004). Vascular actions of natriuretic peptides. Cyclic GMP-dependent and -independent mechanisms. Basic Res Cardiol vol. 99, (2) 83-89.
10.1007/s00395-004-0459-6
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ(2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. P NATL ACAD SCI USA vol. 101, (5) 1386-1391.
10.1073/pnas.0304264101
AHLUWALIA A, Hobbs A, Prescott C, Scotland R, Foster P(2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation vol. 110, (10) 1231-1235.
10.1161/01.CIR.0000141802.29945.34
Hobbs AJ, Moncada S(2003). Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272. Vascul Pharmacol vol. 40, (3) 149-154.
10.1016/s1537-1891(03)00046-6
Madhani M, Scotland RS, MacAllister RJ, Hobbs AJ(2003). Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. Br J Pharmacol vol. 139, (7) 1289-1296.
10.1038/sj.bjp.0705365
Connelly L, Jacobs AT, Palacios-Callender M, Moncada S, Hobbs AJ(2003). Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem vol. 278, (29) 26480-26487.
10.1074/jbc.M302238200
Madhani M, MacAllister R, Hobbs A (2003). Vascular natriuretic peptide receptors modulated by NO-cyclic GMP signalling. BRITISH JOURNAL OF PHARMACOLOGY. vol. 138, U17-U17.
Foster P, Mathur A, McLean P, Perretti M, Moncada S, Ahluwalia A, Hobbs A (2003). Anti-leukocyte properties of a novel non NO-based soluble guanylate cyclase activator, BAY 41-2272. FASEB JOURNAL. vol. 17, A1052-A1052.
Scotland RS, Chauhan SD, Hobbs AJ, Ahluwalia A (2003). Characterisation of eNOS/COX-1 double knockout mice: a novel model for the study of endothelium-derived hyperpolarising factor. FASEB JOURNAL. vol. 17, A225-A225.
Hobbs AJ, Chauhan SD, Nilsson H, Ahluwalia A (2003). Endothelium-derived hyperpolarising factor (EDHF) is C-type natriuretic peptide (CNP) in mesenteric resistance arteries. FASEB JOURNAL. vol. 17, A226-A226.
Chauhan SD, Nilsson H, Ahluwalia A, Hobbs AJ(2003). Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. P NATL ACAD SCI USA vol. 100, (3) 1426-1431.
10.1073/pnas.0336365100
Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S, Cellek S(2003). BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. J Urol vol. 169, (2) 761-766.
10.1097/01.ju.0000043880.58140.69
AHLUWALIA A, Hobbs AJ, Seggara G, Chauhan SD, Vo PA, MacAllister RJ(2003). Protection against liposaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. Faseb J vol. 17, (6) 773-775.
10.1096/fj.02-0668fje
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH, Butler AR(2002). Haemoglobin: NO transporter, NO inactivator or NOne of the above?. Trends Pharmacol Sci vol. 23, (9) 406-411.
10.1016/s0165-6147(02)02067-9
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH, Butler AR(2002). Haernoglobin: NO transporter, NO inactivator or NOne of the above?. TRENDS PHARMACOL SCI vol. 23, (9) 406-411.
10.1016/S0165-6147(02)02067-9
Hobbs AJ(2002). Soluble guanylate cyclase: an old therapeutic target re-visited. Br J Pharmacol vol. 136, (5) 637-640.
10.1038/sj.bjp.0704779
Chauhan SD, MacAllister RJ, Hobbs AJ, Ahluwalia A(2002). Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries. FASEB J vol. 16, (4) A572-A572.
Connelly L, Palacios-Callender M, Ameixa C, Moncada S, Hobbs AJ(2001). Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide. J Immunol vol. 166, (6) 3873-3881.
10.4049/jimmunol.166.6.3873
Hussain MB, MacAllister RJ, Hobbs AJ(2001). Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases. Am J Physiol Heart Circ Physiol vol. 280, (3) H1151-H1159.
10.1152/ajpheart.2001.280.3.H1151
Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA et al.(2001). Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J MED CHEM vol. 44, (1) 78-93.
10.1021/jm001034k
Shah S, Hobbs A, Singh R, Cuevas J, Ignarro LJ, Chaudhuri G(2000). Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY vol. 279, (4) R1478-R1485.
10.1152/ajpregu.2000.279.4.R1478
Cavero M, Hobbs A, Madge D, Motherwell WB, Selwood D, Potier P(2000). Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe. Bioorg Med Chem Lett vol. 10, (7) 641-644.
10.1016/s0960-894x(00)00060-3
Hussain MB, MacAllister RJ, Hobbs AJ(2000). Regulation of cGMP-mediated vasorelaxation in mouse thoracic aorta: Interactions of the soluble and particulate guanylate cyclases. BRIT J PHARMACOL vol. 129,
Hussain MB, Hobbs AJ, MacAllister RJ(1999). Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. Br J Pharmacol vol. 128, (5) 1082-1088.
10.1038/sj.bjp.0702874
Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P, Hobbs AJ(1999). Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity. J Biol Chem vol. 274, (41) 28983-28990.
10.1074/jbc.274.41.28983
Hussain MB, Hobbs AJ, MacAllister RJ(1999). Enhanced sensitivity of the soluble guanylate cyclase/cyclic GMP system in the eNOS knockout mouse. BRIT J PHARMACOL vol. 126, U41-U41.
Hobbs AJ, Higgs A, Moncada S(1999). Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol vol. 39, 191-220.
10.1146/annurev.pharmtox.39.1.191
Hobbs AJ(1997). Soluble guanylate cyclase: the forgotten sibling. Trends Pharmacol Sci vol. 18, (12) 484-491.
10.1016/s0165-6147(97)01137-1
Cohen GA, Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G, Ignarro LJ(1996). Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo. Am J Physiol vol. 271, (1 Pt 2) H133-H139.
10.1152/ajpheart.1996.271.1.H133
Hobbs AJ, Ignarro LJ(1996). Nitric oxide cyclic GMP signal transduction system. NITRIC OXIDE, PT B vol. 269, 134-148.
10.1016/s0076-6879(96)69016-8
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ, CHAUDHURI G(1995). CHANGES IN GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY MAY BE INDUCED BY NITRIC-OXIDE. GASTROENTEROLOGY vol. 108, (4) A688-A688.
10.1016/0016-5085(95)27063-9
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, IGNARRO LJ, ASHLEY SW, CHAUDHURI G(1995). ENHANCED ACTIONS OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE FUNCTION DURING PREGNANCY. GASTROENTEROLOGY vol. 108, (4) A1246-A1246.
10.1016/0016-5085(95)29278-0
HOBBS AJ, COHEN GA, FITCH RM, YIN TL, CHAUDHURI G, IGNARRO LJ(1995). DIFFERENTIAL INHIBITORY EFFECT OF L-NAME ON ENDOTHELIUM-DEPENDENT RELAXATION IN-VITRO AND IN-VIVO. FASEB JOURNAL vol. 9, (3) A328-A328.
COHEN GA, HOBBS AJ, FITCH RM, ASHLEY SW, CRYER MH, CHAUDHURI G, IGNARRO LJ(1995). STIMULATED RELEASE OF NITRIC-OXIDE (NO) IS LINKED TO ALPHA-ADRENOCEPTOR ACTIVATION IN-VIVO. FASEB JOURNAL vol. 9, (3) A328-A328.
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ, CHAUDHURI G(1995). THE ROLE OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY. FASEB JOURNAL vol. 9, (3) A86-A86.
Griscavage JM, Hobbs AJ, Ignarro LJ(1995). Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds. Adv Pharmacol vol. 34, 215-234.
10.1016/s1054-3589(08)61088-1
HOBBS AJ, FUKUTO JM, IGNARRO LJ(1994). FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE - DIRECT ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 91, (23) 10992-10996.
10.1073/pnas.91.23.10992
HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM, IGNARRO LJ(1994). FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. FASEB JOURNAL vol. 8, (4) A360-A360.
HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM, IGNARRO LJ (1994). FORMATION OF FREE NITRIC OXIDE FROM L-ARGININE BY NITRIC OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE DISMUTASE. BIOLOGY OF NITRIC OXIDE, PT 4. vol. 8, 36-42.
Fukuto JM, Hobbs AJ, Ignarro LJ(1993). Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO. Biochem Biophys Res Commun vol. 196, (2) 707-713.
10.1006/bbrc.1993.2307
Brave SR, Bhat S, Hobbs AJ, Tucker JF, Gibson A(1993). The influence of L-NG-nitro-arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle. J Auton Pharmacol vol. 13, (3) 219-225.
10.1111/j.1474-8673.1993.tb00269.x
Gibson A, Babbedge R, Brave SR, Hart SL, Hobbs AJ, Tucker JF, Wallace P, Moore PK(1992). An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus. Br J Pharmacol vol. 107, (3) 715-721.
10.1111/j.1476-5381.1992.tb14512.x
Hobbs AJ, Tucker JF, Gibson A(1991). Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions. Br J Pharmacol vol. 104, (3) 645-650.
10.1111/j.1476-5381.1991.tb12483.x
Brave SR, Hobbs AJ, Gibson A, Tucker JF(1991). The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle. Biochem Biophys Res Commun vol. 179, (2) 1017-1022.
10.1016/0006-291x(91)91920-8
Mirzazadeh S, Hobbs AJ, Tucker JF, Gibson A(1991). Cyclic nucleotide content of the rat anococcygeus during relaxations induced by drugs or by non-adrenergic, non-cholinergic field stimulation. J Pharm Pharmacol vol. 43, (4) 247-251.
10.1111/j.2042-7158.1991.tb06677.x
Tucker JF, Brave SR, Charalambous L, Hobbs AJ, Gibson A(1990). L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br J Pharmacol vol. 100, (4) 663-664.
10.1111/j.1476-5381.1990.tb14072.x
Hobbs AJ, Gibson A(1990). L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus. Br J Pharmacol vol. 100, (4) 749-752.
10.1111/j.1476-5381.1990.tb14086.x
Gibson A, Mirzazadeh S, Hobbs AJ, Moore PK(1990). L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle. Br J Pharmacol vol. 99, (3) 602-606.
10.1111/j.1476-5381.1990.tb12976.x
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