Publications: Dr Jessica Okosun
Alderuccio JP, Khwaja J, Han S, Ghione P, Nizamuddin IA, Saha A, Dong N, Wang Y et al.
(
2024
)
.
Prognostication and Treatment-Related Outcomes in Secondary Central Nervous System Involvement of Large B-Cell Lymphoma (SCNSL): Evidence from a Large International Cohort
.
Blood
vol.
144
,
(
Supplement 1
)
571
-
571
.
Collin M, Gagey G, Shanmugam V, Louissaint A, Okosun J, Sarkozy C, Nadel B
(
2024
)
.
Follicular lymphoma research: an open dialogue for a collaborative roadmap
.
Histopathology
Kumar EA, Korfi K, Bewicke‐Copley F, Close K, Heward J, Witzig T, Leukam M, Ansell S et al.
(
2024
)
.
CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma
.
British Journal of Haematology
vol.
205
,
(
5
)
1804
-
1809
.
Jamal E, Poynton E, Elbogdady M, Shamaa S, Okosun J
(
2024
)
.
Prospects for liquid biopsy approaches in lymphomas
.
Leukemia & Lymphoma
vol.
ahead-of-print
,
(
ahead-of-print
)
1
-
11
.
Poynton E, Chernucha E, Day J, Prodger C, Hopkins D, Rakesh P, O’Neill T, Thakrar N et al.
(
2024
)
.
Impact of MYC and BCL2 double expression on outcomes in primary CNS lymphoma: a UK multicenter analysis
.
Blood Advances
.
vol.
8
,
1772
-
1775
.
McIlroy G, Lax S, Gaskell C, Jackson A, Rhodes M, Seale T, Fox S, Hopkins L et al.
(
2024
)
.
Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial
.
BMC Cancer
vol.
24
,
(
1
)
Xu D, Bewicke-Copley F, Close K, Okosun J, Gale RP, Apperley J, Weinstock DM, Wendel H-G et al.
(
2024
)
.
Targeting lysine demethylase 5 (KDM5) in mantle cell lymphoma
.
Blood Cancer Journal
vol.
14
,
(
1
)
Coulter EM, Bewicke-Copley F, Mossner M, Graham TA, Fitzgibbon J, Okosun J
(
2024
)
.
Defining an Optimized Workflow for Enriching and Analyzing Residual Tumor Populations Using Intracellular Markers
.
Journal of Molecular Diagnostics
vol.
26
,
(
4
)
245
-
256
.
Parry EM, Roulland S, Okosun J
(
2023
)
.
DLBCL arising from indolent lymphomas: How are they different?
.
Seminars in Hematology
vol.
60
,
(
5
)
277
-
284
.
Poynton E, Chernucha E, Day J, Prodger C, Hopkins D, Rakesh P, O'Neill T, Thakrar N et al.
(
2023
)
.
ABCL-184 Impact of MYC and BCL2 Double Expression on Outcomes in Primary CNS Lymphoma: A UK Multicenter Analysis
.
Clinical Lymphoma Myeloma & Leukemia
vol.
23
,
s423
-
s424
.
Okosun J
(
2023
)
.
EXABS-109-LYM Should We Use Prognostic Indices and/or Biomarkers to Guide Therapy in Follicular Lymphoma?
.
Clinical Lymphoma Myeloma & Leukemia
vol.
23
,
s11
-
s13
.
Poynton E, Chernucha E, Day J, Prodger C, Hopkins D, Rakesh P, O'Neill T, Thakrar N et al.
(
2023
)
.
POSTER: ABCL-184 Impact of MYC and BCL2 Double Expression on Outcomes in Primary CNS Lymphoma: A UK Multicenter Analysis
.
Clinical Lymphoma Myeloma & Leukemia
vol.
23
,
Linton KM, Specht L, Pavlovsky A, Thompson CA, Kimby E, de Jong D, Nastoupil LJ, Cottereau A et al.
(
2023
)
.
Personalised therapy in follicular lymphoma – is the dial turning?
.
Hematological Oncology
vol.
42
,
(
6
)
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S et al.
(
2023
)
.
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma
.
Blood Advances
vol.
7
,
(
5
)
845
-
855
.
Knight CH, Khan F, Patel A, Gill US, Okosun J, Wang J
(
2023
)
.
IBRAP: integrated benchmarking single-cell RNA-sequencing analytical pipeline
.
Briefings in Bioinformatics
vol.
24
,
(
2
)
El‐Galaly TC, Gaidzik VI, Gaman M, Antic D, Okosun J, Copland M, Sexl V, Fielding AK et al.
(
2023
)
.
A Lack of Diversity, Equity, and Inclusion in Clinical Research Has Direct Impact on Patient Care
.
HemaSphere
vol.
7
,
(
3
)
Perrett M, Edmondson C, Okosun J
(
2022
)
.
Biology of follicular lymphoma: insights and windows of clinical opportunity
.
Hematology
vol.
2022
,
(
1
)
688
-
694
.
Poynton E, Chernucha E, Day J, Prodger C, Hopkins D, Rakesh P, O'Neill T, Thakrar N et al.
(
2022
)
.
Impact of Double Expression of MYC and BCL-2 on Outcomes in Primary CNS Lymphoma: A UK Multicentre Analysis
.
Blood
vol.
140
,
(
Supplement 1
)
372
-
374
.
Perrett M, Pickard L, Kumar E, Palladino G, Khan F, Edmondson C, Knight C, Poynton E et al.
(
2022
)
.
Longitudinal Single Cell Analyses Reveal the Co-Evolutionary Dynamics of the Tumor and Microenvironment Accompanying Follicular Lymphoma Transformation
.
Blood
vol.
140
,
(
Supplement 1
)
748
-
749
.
Alcoceba M, García-Álvarez M, Okosun J, Ferrero S, Ladetto M, Fitzgibbon J, García-Sanz R
(
2022
)
.
Genetics of Transformed Follicular Lymphoma
.
Hemato
vol.
3
,
(
4
)
615
-
633
.
Wendler J, Fox CP, Valk E, Steinheber C, Fricker H, Isbell LK, Neumaier S, Okosun J et al.
(
2022
)
.
Optimizing MATRix as remission induction in PCNSL: de-escalated induction treatment in newly diagnosed primary CNS lymphoma
.
BMC Cancer
vol.
22
,
(
1
)
Ngu H, Takiar R, Phillips T, Okosun J, Sehn LH
(
2022
)
.
Revising the Treatment Pathways in Lymphoma: New Standards of Care-How Do We Choose?
.
American Society of Clinical Oncology Educational Book
vol.
42
,
(
42
)
1
-
14
.
Eyre TA, Barrington SF, Okosun J, Abamba C, Pearce RM, Lee J, Carpenter B, Crawley CR et al.
(
2022
)
.
Impact of positron emission tomography - computed tomography status on progression-free survival for relapsed follicular lymphoma patients undergoing autologous stem cell transplantation
.
Haematologica
vol.
108
,
(
3
)
785
-
796
.
Dreyling M, André M, Gökbuget N, Tilly H, Jerkeman M, Gribben J, Ferreri A, Morel P et al.
(
2022
)
.
The EHA Research Roadmap: Malignant Lymphoid Diseases
.
HemaSphere
vol.
6
,
(
6
)
Okosun J
(
2021
)
.
Molecular Pathogenesis of Follicular Lymphoma and Its Relevance to Clinical Practice
.
Clinical Lymphoma Myeloma & Leukemia
vol.
21
,
(
Science 228 4706 1985
)
s175
-
s177
.
Perrett M, Okosun J
(
2021
)
.
Genetic heterogeneity in follicular lymphoma
.
Annals of Lymphoma
vol.
5
,
(
0
)
18
-
18
.
Wu F, Watanabe N, Tzioni M-M, Akarca A, Zhang C, Li Y, Chen Z, Cucco F et al.
(
2021
)
.
Thyroid MALT lymphoma: self-harm to gain potential T-cell help
.
Leukemia
vol.
35
,
(
12
)
3497
-
3508
.
Poynton E, Okosun J
(
2021
)
.
Liquid biopsy in lymphoma: Is it primed for clinical translation?
.
eJHaem
vol.
2
,
(
3
)
616
-
627
.
Heward J, Konali L, D'Avola A, Close K, Yeomans A, Philpott M, Dunford J, Rahim T et al.
(
2021
)
.
KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas
.
Blood
vol.
138
,
(
5
)
370
-
381
.
Kumar E, Pickard L, Okosun J
(
2021
)
.
Pathogenesis of follicular lymphoma: genetics to the microenvironment to clinical translation
.
British Journal of Haematology
vol.
194
,
(
5
)
810
-
821
.
Larrea E, Fernandez-Mercado M, Guerra-Assunção JA, Wang J, Goicoechea I, Gaafar A, Ceberio I, Lobo C et al.
(
2020
)
.
Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma
.
International Journal of Molecular Sciences
vol.
21
,
(
22
)
Uyulur F, Bewicke-Copley F, Anene CA, Schlesner M, Project IM-S, Siebert R, Okosun J, Fitzgibbon J et al.
(
2020
)
.
Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma
.
Blood
vol.
136
,
(
Supplement 1
)
26
-
27
.
Okosun J
(
2020
)
.
Abstract IA38: Defining lymphoma reservoirs: Clues from the genomics
.
Blood Cancer Discovery
vol.
1
,
(
3_Supplement
)
ia38
-
ia38
.
Pickard L, Palladino G, Okosun J
(
2020
)
.
Follicular lymphoma genomics
.
Leukemia & Lymphoma
vol.
61
,
(
10
)
2313
-
2323
.
Aries JA, Davies JK, Auer RL, Hallam SL, Montoto S, Smith M, Sevillano B, Foggo V et al.
(
2020
)
.
Clinical Outcome of Coronavirus Disease 2019 in Haemato-oncology Patients
.
British Journal of Haematology
Kumar EA, Okosun J, Fitzgibbon J
(
2020
)
.
The Biological Basis of Histologic Transformation
.
Hematology/Oncology Clinics of North America
vol.
34
,
(
4
)
771
-
784
.
Okosun J, Montoto S
(
2020
)
.
Cellular Therapy in Follicular Lymphoma Autologous Stem Cell Transplantation, Allogeneic Stem Cell Transplantation, and Chimeric Antigen Receptor T-cell Therapy
.
Hematology/Oncology Clinics of North America
vol.
34
,
(
4
)
701
-
714
.
Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al.
(
2020
)
.
Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma
.
Haematologica
vol.
105
,
(
6
)
318
-
321
.
Krysov S, Odabashian M, Carlotti E, Araf S, Okosun J, Spada F, Gribben J, Forconi F et al.
(
2020
)
.
IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution
.
Blood
vol.
135
,
(
11
)
834
-
844
.
Bewicke-Copley F, Korfi K, Araf S, Kumar EA, Cummin TEC, Ashton-Key M, Barrans S, Van Hoppe S et al.
(
2019
)
.
Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel
.
Blood
vol.
134
,
(
Supplement_1
)
Ortega-Molina A, Deleyto-Seldas N, Carreras J, Sanz A, Lebrero-Fernández C, Menéndez C, Vandenberg A, Fernández-Ruiz B et al.
(
2019
)
.
Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR
.
Nature Metabolism
vol.
1
,
(
8
)
775
-
789
.
Matasar MJ, Luminari S, Barr PM, Barta SK, Danilov AV, Hill BT, Phillips TJ, Jerkeman M et al.
(
2019
)
.
Follicular Lymphoma: Recent and Emerging Therapies, Treatment Strategies, and Remaining Unmet Needs
.
The Oncologist
vol.
24
,
(
11
)
e1236
-
e1250
.
Kumar E, Okosun J
(
2019
)
.
Follicular lymphoma genomics
.
HemaSphere
vol.
3
,
(
Suppl
)
79
-
81
.
Kumar E, Korfi K, Bewicke‐Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al.
(
2019
)
.
PF513 MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
.
HemaSphere
vol.
3
,
(
S1
)
Bödör C, Batlevi C, Nagy N, Michot J, Schneider T, Alizadeh H, Simon Z, Vose J et al.
(
2019
)
.
PS1247 EZH2 GAIN‐OF‐FUNCTION MUTATIONS ARE NOT ASSOCIATED WITH MORE FAVORABLE PROGNOSIS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA: A PRELIMINARY ANALYSIS ON 590 PATIENTS
.
HemaSphere
vol.
3
,
(
S1
)
568
-
569
.
Heward J, Koniali L, D’Avola A, Close K, Yeomans A, Johnson P, Okosun J, Neve R et al.
(
2019
)
.
S844 KDM5 INHIBITION OFFERS A NOVEL THERAPEUTIC STRATEGY FOR THE TREATMENT OF KMT2D MUTANT LYMPHOMAS
.
HemaSphere
vol.
3
,
(
S1
)
376
-
377
.
Okosun J, Bödör C, Batlevi C, Nagy N, Michot J, Schneider T, Alizadeh H, Simon Z et al.
(
2019
)
.
EZH2 GAIN‐OF‐FUNCTION MUTATIONS ARE NOT ASSOCIATED WITH MORE FAVORABLE PROGNOSIS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA (FL): A PRELIMINARY ANALYSIS ON 590 PATIENTS
.
Hematological Oncology
vol.
37
,
(
S2
)
192
-
193
.
Korfi K, Araf S, Bewicke‐Copley F, Kumar E, Cummin T, Ashton‐Key M, Barrans S, Van Hoppe S et al.
(
2019
)
.
LONGITUDINAL ANALYSES OF DIAGNOSTIC‐RELAPSE BIOPSIES OF DIFFUSE LARGE B CELL LYMPHOMA SUGGEST THAT RELAPSE IS MEDIATED BY DISTINCT MECHANISMS IN ABC AND GCB LYMPHOMA
.
Hematological Oncology
vol.
37
,
(
S2
)
142
-
143
.
Pettitt AR, Barrington S, Kalakonda N, Khan UT, Jackson R, Carruthers S, Oates M, Lin K et al.
(
2019
)
.
NCRI PETREA TRIAL: A PHASE 3 EVALUATION OF PET‐GUIDED, RESPONSE‐ADAPTED THERAPY IN PATIENTS WITH PREVIOUSLY UNTREATED, ADVANCED‐STAGE, HIGH‐TUMOUR‐BURDEN FOLLICULAR LYMPHOMA
.
Hematological Oncology
vol.
37
,
(
S2
)
67
-
68
.
Kumar E, Korfi K, Bewicke-Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al.
(
2019
)
.
MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
.
HemaSphere
vol.
3
,
Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al.
(
2019
)
.
Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant
.
Haematologica
vol.
104
,
(
4
)
e174
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e177
.
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.
(
2019
)
.
Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
.
Leukemia
vol.
33
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6
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1540
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1540
.
Odabashian M, Carlotti E, Araf S, Okosun J, Forconi F, Stevenson FK, Gribben JG, Calaminici M et al.
(
2018
)
.
Immunoglobulin Variable Region Gene Sequences Reveal N-Glycosylation Motifs As an Early and Stable Event in Follicular Lymphoma Pathology
.
Blood
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Conference:
Search Results Web results ASH Meeting on Lymphoma Biology
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132
,
4101
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4101
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Okosun J, Kridel R, Fitzgibbon J
(
2018
)
.
Rituximab as a first step in tackling transformation
.
The Lancet Haematology
vol.
5
,
(
8
)
e326
-
e327
.
Heward JA, Kumar EA, Korfi K, Okosun J, Fitzgibbon J
(
2018
)
.
Precision medicine and lymphoma
.
Curr Opin Hematol
vol.
25
,
(
4
)
329
-
334
.
Araf S, Okosun J, Fitzgibbon J
(
2018
)
.
Predicting early relapse in follicular lymphoma: have we turned a corner?
.
The Lancet Oncology
vol.
19
,
(
4
)
441
-
442
.
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al.
(
2018
)
.
Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
.
Leukemia
vol.
32
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5
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1261
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1265
.
Horton SJ, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford-Rogers R, Rashid M, Clipson A et al.
(
2017
)
.
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
.
Nature Cell Biology
.
vol.
19
,
1093
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1104
.
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward JA et al.
(
2017
)
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Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma
.
BLOOD
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130
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Araf S, Korfi K, Nagano A, Cummin TEC, Bentley M, Thorner AR, Ashton-Key M, Calaminici M et al.
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2017
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Longitudinal Analyses of the Genomic, Transcriptomic, and T Cell Repertoire in Diffuse Large B Cell Lymphoma Demonstrates Changes in Signaling and Immune Recognition at Relapse
.
BLOOD
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130
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Larrea E, Fernandez-Mercado M, Ceberio I, Assuncao JAG, Okosun J, Fitzgibbon J, Lawrie C
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2017
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RECURRENT MUTATIONS IN MICRO-RNA BINDING SITES MAY BE POTENTIALLY RELEVANT IN FOLLICULAR LYMPHOMA
.
HAEMATOLOGICA
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Noerenberg D, Mansouri L, Young E, Mareike F, Abdulla M, Asmar F, Gonzalez-Farre B, Anna T et al.
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ΝFΚΒΙΕ Deletions: A Novel Marker of Clinical Aggressiveness in Primary Mediastinal B-Cell Lymphoma
.
Blood
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Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V et al.
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Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
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Blood
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2666
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Larrea E, Fernandez-Mercado M, Ceberio I, Guerra-Assunção JA, Okosun J, Fitzgibbon J, Lawrie C
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2016
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110 Follicular lymphoma cases harbour recurrent mutations in micro-RNA binding sites of genes associated with lymphomagenesis
.
European Journal of Cancer
vol.
61
,
s11
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s12
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Okosun J, Montoto S, Fitzgibbon J
(
2016
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The routes for transformation of follicular lymphoma
.
Current Opinion in Hematology
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23
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4
)
1
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1
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Kotsiou E, Okosun J, Besley C, Iqbal S, Matthews J, Fitzgibbon J, Gribben J, DAVIES JK
(
2016
)
.
TNFRSF14 aberrations in follicular lymphoma increase clinically significant allogeneic T-cell responses
.
Blood
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128
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72
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81
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Okosun J, Fitzgibbon J
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2016
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5. Follicular lymphoma
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Malignant Lymphomas
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De Gruyter
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al.
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2016
)
.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
.
Nature Genetics
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48
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2
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183
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188
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Okosun J, Fitzgibbon J
(
2016
)
.
Follicular lymphoma
.
Malignant Lymphomas: Biology and Molecular Pathogenesis
,
Larrea E, Fernandez-Mercado M, Ceberio I, Guerra-Assuncao JA, Okosun J, Fitzgibbon J, Lawrie C
(
2016
)
.
Follicular lymphoma cases harbour recurrent mutations in microRNA binding sites of genes associated with lymphomagenesis
.
EUROPEAN JOURNAL OF CANCER
.
vol.
61
,
S11
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S12
.
Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al.
(
2016
)
.
GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE
.
HAEMATOLOGICA
.
vol.
101
,
270
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270
.
Araf S, Okosun J, Koniali L, Fitzgibbon J, Heward J
(
2015
)
.
Epigenetic dysregulation in follicular lymphoma
.
Epigenomics
vol.
8
,
(
1
)
77
-
84
.
Okosun J, Cwynarski K
(
2015
)
.
Non‐Hodgkin Lymphoma: High Grade
.
Postgraduate Haematology
,
Wiley
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al.
(
2015
)
.
Disease evolution and outcomes in familial AML with germline CEBPA mutations
.
Blood
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126
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(
10
)
1214
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1223
.
Okosun J, Packham G, Fitzgibbon J
(
2014
)
.
Investigational epigenetically targeted drugs in early phase trials for the treatment of haematological malignancies
.
Expert Opinion on Investigational Drugs
vol.
23
,
(
10
)
1321
-
1332
.
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al.
(
2014
)
.
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
.
Nature Genetics
vol.
46
,
(
2
)
176
-
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