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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Reshma Nahal

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Grange RMH, Preedy MEJ, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez‐Ternero C, Aubdool AA et al. ( 2021 ) . Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature . British Journal of Pharmacology vol. 179 , ( 11 ) 2443 - 2459 .
Scott TE, Ung V, Baliga RS, Robertson AAB, Nold-Petry CA, Nold MF, Drummond GR, Hobbs AJ et al. ( 2020 ) . Targeting the NLRP3 Inflammasome as a Novel Approach to Treat Pulmonary Hypertension . Conference: American Thoracic Societya3830 - a3830 .
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease . The Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .
Preedy MEJ, Baliga RS, Hobbs AJ ( 2019 ) . Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure . Journal of Cardiovascular Pharmacology
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K et al. ( 2019 ) . Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial . British Journal of Pharmacology vol. 176 , ( 9 ) 1251 - 1267 .
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al. ( 2019 ) . C-type natriuretic peptide co-ordinates cardiac structure and function . European Heart Journal vol. 41 , ( 9 )
Preedy ME, Baliga RS, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. ( 2019 ) . Inhibition of phosphodiesterase 2 reverses the development of heart failure by promoting NO/guanylyl cyclase/cGMP signalling . BRITISH JOURNAL OF PHARMACOLOGY . vol. 176 , 3008 - 3009 .
Preedy MEJ, Baliga R, Dukinfield M, Chu S, Aubdool A, Bubb K, Moyes A, Tones M et al. ( 2019 ) . Phosphodiesterase 2 promotes nitric oxide/guanylyl cyclase/cGMP signalling in heart failure . JOURNAL OF TRANSLATIONAL MEDICINE . vol. 17 ,
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. ( 2018 ) . Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure . Proc Natl Acad Sci U S A
Baliga RS, Moyes AJ, Villar IC, Schaeper U, Iannone L, Hobbs AJ ( 2016 ) . Therapeutic Proof-Of-Concept For Novel Sirna Technology In Experimental Pulmonary Hypertension . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 193 ,
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ ( 2015 ) . Abstract 19478: Endothelial and Cardiomyocyte -derived C-type Natriuretic Peptide Coordinate Heart Structure and Function . Circulation vol. 132 , ( suppl_3 )
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ ( 2015 ) . Endothelial and Cardiomyocyte-derived C-type Natriuretic Peptide Coordinate Heart Structure and Function . CIRCULATION . vol. 132 ,
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al. ( 2014 ) . Endothelial C-type natriuretic peptide maintains vascular homeostasis . J Clin Invest vol. 124 , ( 9 ) 4039 - 4051 .
Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ, Hobbs AJ ( 2014 ) . Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension . Circulation vol. 130 , ( 6 ) 496 - 507 .
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ ( 2014 ) . Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis . Br J Pharmacol vol. 171 , ( 14 ) 3463 - 3475 .
Hobbs A, Bubb K, Trinder S, Baliga R, MacAllister R ( 2014 ) . PHOSPHODIESTERASE 2 IS A NOVEL THERAPEUTIC TARGET IN PULMONARY HYPERTENSION . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 115 , 40 - 41 .
Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ et al. ( 2013 ) . Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension . Arthritis Rheum vol. 65 , ( 11 ) 2928 - 2939 .
Baliga RS, MacAllister RJ, Hobbs AJ ( 2013 ) . Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application . Pharmacotherapy of Pulmonary Hypertension , vol. 218 , Springer Nature
Bubb KJ, Trinder S, Baliga R, MacAllister RJ, Hobbs AJ ( 2013 ) . Validation Of Phosphodiesterase 2 As A Novel Therapeutic Target In Pulmonary Hypertension . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 187 ,
Baliga RS, Macallister RJ, Hobbs AJ ( 2013 ) . Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application . Handb Exp Pharmacol vol. 218 , 477 - 511 .
Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A, Hobbs AJ ( 2012 ) . Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase . Circulation vol. 125 , ( 23 ) 2922 - 2932 .
Zhang T, Lu X, Arnold P, Liu Y, Baliga R, Huang H, Bauer JA, Liu Y et al. ( 2012 ) . Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-α expression and improves cardiac function during endotoxemia . Cardiovasc Res vol. 93 , ( 3 ) 471 - 479 .
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham D, Denton C ( 2012 ) . SYSTEMIC VEGF INHIBITION INDUCES PULMONARY ARTERIAL HYPERTENSION IN A TRANSGENIC MOUSE MODEL OF SCLERODERMA . RHEUMATOLOGY . vol. 51 , 41 - 41 .
Baliga RS, MacAllister RJ, Hobbs AJ ( 2011 ) . New perspectives for the treatment of pulmonary hypertension . Br J Pharmacol vol. 163 , ( 1 ) 125 - 140 .
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ ( 2011 ) . Protective Role Of Natriuretic Peptides In Pulmonary Fibrosis: A Novel Therapeutic Target? . Conference: C61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS IIa6409 - a6409 .
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton C ( 2011 ) . AN EXPLORATION OF PULMONARY VASCULAR VEGF SIGNALLING IN A TGF beta-DEPENDENT MOUSE MODEL OF SYSTEMIC SCLEROSIS . RHEUMATOLOGY . vol. 50 , 134 - 135 .
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham DJ, Denton CP ( 2011 ) . Intermittent Systemic VEGF Inhibition Induces Pulmonary Arterial Hypertension In a Transgenic Mouse Model of Scleroderma . ARTHRITIS AND RHEUMATISM . vol. 63 , S1022 - S1023 .
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton CP ( 2010 ) . Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis . CLIN EXP RHEUMATOL vol. 28 , ( 5 ) S63 - S63 .
Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M, Hobbs AJ ( 2010 ) . Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A . Br J Pharmacol vol. 160 , ( 8 ) 2045 - 2054 .
Derrett-Smith EC, Baliga R, Dooley A, Khan K, Shi-Wen X, Abraham D, Denton CP ( 2010 ) . FIBROBLAST-SPECIFIC ACTIVATION OF TGF beta IN VIVO RECAPITULATES A HYPOXIC PULMONARY HYPERTENSION PHENOTYPE IN MICE . RHEUMATOLOGY . vol. 49 , I112 - I113 .
Yazdani R, Abhishek A, Fiona P, Lim K, Regan M, Lanyon P, Khan K, Hoyles RK et al. ( 2010 ) . Scleroderma and Related Disorders [202–212] . Rheumatology vol. 49 , ( suppl_1 ) i111 - i115 .
Derrett-Smith E, Baliga R, Khan K, Shi-Wen X, Abraham D, Denton C ( 2010 ) . FIBROBLAST-SPECIFIC ACTIVATION OF TGF-BETA IN MICE RECAPITULATES A HYPOXIC PULMONARY HYPERTENSION PHENOTYPE . CLIN EXP RHEUMATOL vol. 28 , ( 2 ) S106 - S106 .
Han B, Baliga R, Huang H, Giannone PJ, Bauer JA ( 2009 ) . Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy . Am J Physiol Heart Circ Physiol vol. 297 , ( 2 ) H829 - H835 .
Chaves AA, Joshi MS, Coyle CM, Brady JE, Dech SJ, Schanbacher BL, Baliga R, Basuray A et al. ( 2009 ) . Vasoprotective endothelial effects of a standardized grape product in humans . Vascul Pharmacol vol. 50 , ( 1-2 ) 20 - 26 .
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ et al. ( 2008 ) . Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension . Am J Respir Crit Care Med vol. 178 , ( 8 ) 861 - 869 .
Marro ML, Peiro C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW, Hobbs AJ ( 2008 ) . Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor . J BIOL CHEM vol. 283 , ( 29 ) 20027 - 20036 .
Luce WA, Huang H, Baliga R, Gannone PJ, Liu Y, Bauer JA ( 2007 ) . Role of mitogen activated protein kinase phosphatase-1 (MKP-1) in endotoxin-induced cardiac dysfunction . CIRCULATION . vol. 116 , 6 - 6 .
Baliga R, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ ( 2007 ) . Selective modulation of ANP-dependent dilation in the pulmonary vasculature by PDE 5 inhibitors: A novel combination therapy for pulmonary hypertension? . CIRCULATION . vol. 116 , 456 - 456 .
Luce WA, Huang H, Baliga R, Giannone PJ, Liu Y, Bauer JA ( 2007 ) . Deficiency of mitogen activated protein kinase phosphatase-1 (mkp-1) causes enhanced impairment of cardiac function after endotoxin exposure . PEDIATRIC RESEARCH . vol. 62 , 517 - 517 .
Baliga RS, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ ( 2007 ) . Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDE 5 inhibitors: a novel combination therapy for pulmonary hypertension? . BMC Pharmacology vol. 7 , ( Suppl 1 )
Huang H, Baliga R, Wang XX, Han B, Luce W, Joshi M, Nelin L, Liu Y et al. ( 2007 ) . Mitogen activated protein kinase phosphatase-1 plays an important role in sepsis-related cardiac dysfunction . FASEB JOURNAL . vol. 21 , A804 - A804 .
Han B, Baliga RS, Huang H, Cook AC, Joshi MS, Schanbacher BL, Bauer JA ( 2007 ) . Alterations in cardiac connexin 43 and microvessel prevalence with ventricular performance deficits during murine diabetic cardiornyopathy . FASEB JOURNAL . vol. 21 , A436 - A436 .
Liu YS, Zhao Q, Wang XX, Nelin LD, Yao YX, Chang CH, Baliga R, Meng XM et al. ( 2006 ) . MAP kinase phosphatase-1 controls innate immune responses and suppresses endotoxic shock . FASEB JOURNAL . vol. 20 , A1377 - A1377 .
Han B, Baliga R, Schanbacher B, Bauer JA ( 2006 ) . Oxidant modulation of cardiac function: Inhibition of glutathione biosynthesis alters cardiac performance in mice . FASEB JOURNAL . vol. 20 , A322 - A322 .
Chaves AA, Baliga RS, Mihm MJ, Schanbacher BL, Basuray A, Liu C, Cook AC, Ayers LW et al. ( 2006 ) . Bacterial lipopolysaccharide enhances cardiac dysfunction but not retroviral replication in murine AIDS: roles of macrophage infiltration and toll-like receptor 4 expression . Am J Pathol vol. 168 , ( 3 ) 727 - 735 .
Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, Baliga RS, Meng X et al. ( 2006 ) . MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock . J Exp Med vol. 203 , ( 1 ) 131 - 140 .
Baliga RS, Chaves AA, Jing L, Ayers LW, Bauer JA ( 2005 ) . AIDS-related vasculopathy: evidence for oxidative and inflammatory pathways in murine and human AIDS . Am J Physiol Heart Circ Physiol vol. 289 , ( 4 ) H1373 - H1380 .
Malik F, Elias KA, Finer JT, Morgan BP, Sakowicz R, Anderson R, Baliga R, Conn L et al. ( 2005 ) . Direct activation of cardiac myosin by CK-1827452 improves cardiac function in a dog heart failure model . JOURNAL OF CARDIAC FAILURE . vol. 11 , S95 - S95 .
Baliga RS, Carnes CA, Cook AC, Bauer JA ( 2004 ) . Characterization of diabetic cardiomyopathy development in a mouse streptozotocin model: Reasons and consequences . PEDIATRIC RESEARCH . vol. 55 , 153A - 153A .
Baliga RS, Mihm MJ, Carnes CA, McCarthy PM, Van Wagoner DR, Bauer JA ( 2004 ) . Chronic human atrial fibrillation - Immune infiltration and endothelial activation . FASEB JOURNAL . vol. 18 , A230 - A230 .
Baliga RS, Carnes CA, Bauer JA ( 2004 ) . Diabetic cardiomyopathy in a mouse streptozotocin model . FASEB JOURNAL . vol. 18 , A576 - A576 .
Chaves AA, Mihm MJ, Basuray A, Baliga R, Ayers LW, Bauer JA ( 2004 ) . HIV/AIDS-related cardiovascular disease . Cardiovasc Toxicol vol. 4 , ( 3 ) 229 - 242 .
Baliga RS, Carnes CA, Cook AC, Bauer JA ( 2004 ) . Mitral regurgitation - Roles of reactive nitrogen species and immune infiltrates . FASEB JOURNAL . vol. 18 , A602 - A603 .
Bauer JA, Baliga RS, Mihm MJ, Cook AC, McCarthy PM, Carnes CA, VanWagoner DR ( 2004 ) . Reactive nitrogen species formation during chronic human atrial fibrillation: Sources and consequences . FASEB JOURNAL . vol. 18 , A603 - A603 .
Baliga RS, Carnes CA, Hamlin RL, Nakayama T, Bauer JA ( 2004 ) . Reactive nitrogen species in a dog model of mitral regurgitation: Sources and consequences . PEDIATRIC RESEARCH . vol. 55 , 589A - 589A .
Baliga RS, Liu C, Hoyt DG, Chaves AA, Bauer JA ( 2004 ) . Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis . Cardiovasc Toxicol vol. 4 , ( 2 ) 199 - 206 .
Pitre-Poladia D, Baliga R, Bauer JA ( 2003 ) . Urinary bladder dysfunction during diabetes: Functional, structural, and neuronal investigations of a mouse model . PEDIATRIC RESEARCH . vol. 53 , 135A - 135A .
Chaves AA, Coyle CM, Brady JE, Dech SJ, Joshi MS, Schanbacher BL, Baliga R, Basuray A et al. ( 2003 ) . Vasoprotective effects of a standardized grape product in humans . FASEB JOURNAL . vol. 17 , A237 - A237 .
Baliga RS, Liu C, Chaves AA, Jing L, Bauer JA ( 2003 ) . Mechanistic studies in a mouse model of AIDS related vasculopathy: involvement of reactive nitrogen species . FASEB JOURNAL . vol. 17 , A650 - A650 .
Baliga RS, Lui C, Jing L, Chaves AA, Bauer JA ( 2003 ) . Time dependent vascular dysfunction in murine AIDS: Evidence for involvement of reactive nitrogen species . PEDIATRIC RESEARCH . vol. 53 , 558A - 558A .
Chaves AA, Coyle CM, Brady JE, Dech SJ, Joshi MS, Schanbacher BL, Basuray A, Baliga RS et al. ( 2003 ) . Vascular endothelial effects of a standardized grape product in humans . PEDIATRIC RESEARCH . vol. 53 , 559A - 559A .
Baliga RS, Carnes CA, Chung MK, Nakayama H, Nakayama T, Piao S, Kanderian A, Pavia S et al. ( 2002 ) . Ascorbate attenuates atrial pacing-induced peroxynitrite formation, electrical remodeling and the incidence of post-operative atrial fibrillation . FASEB JOURNAL vol. 16 , ( 4 ) A176 - A177 .
Bauer JA, Baliga RS, Liu CY, Jones C, Hoyt DG ( 2002 ) . Endothelial toxicity induced by HIV protease inhibitors: Evidence of oxidant related dysfunction and apoptosis . PEDIATRIC RESEARCH vol. 51 , ( 4 ) 465A - 465A .
Carnes CA, Chung MK, Nakayama T, Nakayama H, Baliga RS, Piao S, Kanderian A, Pavia S et al. ( 2001 ) . Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation . Circ Res vol. 89 , ( 6 ) E32 - E38 .
Kubota I, Han X, Opel DJ, Zhao YY, Baliga R, Huang P, Fishman MC, Shannon RP et al. ( 2000 ) . Increased susceptibility to development of triggered activity in myocytes from mice with targeted disruption of endothelial nitric oxide synthase . J Mol Cell Cardiol vol. 32 , ( 7 ) 1239 - 1248 .
Liu CY, Jones C, Chaves AA, Baliga R, Hoyt D, Bauer JA ( 2000 ) . HIV protease inhibitors promote endothelial dysfunction and oxidant formation . FASEB J vol. 14 , ( 8 ) A1563 - A1563 .
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