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Publications:  Dr Reshma Nahal

Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al.(2020). C-type natriuretic peptide co-ordinates cardiac structure and function. European Heart Journal vol. 41, (9) 1006-1020.
10.1093/eurheartj/ehz093
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56755
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.(2019). Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. Journal of Pathology vol. 249, (4) 523-535.
10.1002/path.5340
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59784
Preedy MEJ, Baliga R, Dukinfield M, Chu S, Aubdool A, Bubb K, Moyes A, Tones M et al. (2019). Phosphodiesterase 2 promotes nitric oxide/guanylyl cyclase/cGMP signalling in heart failure. JOURNAL OF TRANSLATIONAL MEDICINE. vol. 17,
Preedy ME, Baliga RS, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al. (2019). Inhibition of phosphodiesterase 2 reverses the development of heart failure by promoting NO/guanylyl cyclase/cGMP signalling. BRITISH JOURNAL OF PHARMACOLOGY. vol. 176, 3008-3009.
Preedy MEJ, Baliga RS, Hobbs AJ(2019). Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure. Journal of Cardiovascular Pharmacology
10.1097/FJC.0000000000000724
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61998
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K et al.(2019). Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial. Br J Pharmacol vol. 176, (9) 1251-1267.
10.1111/bph.14621
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55912
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al.(2018). Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure. Proc Natl Acad Sci U S A
10.1073/pnas.1800996115
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42747
Baliga RS, Moyes AJ, Villar IC, Schaeper U, Iannone L, Hobbs AJ, Pharmacology C (2016). Therapeutic Proof-Of-Concept For Novel Sirna Technology In Experimental Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 193,
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ (2015). Endothelial and Cardiomyocyte-derived C-type Natriuretic Peptide Coordinate Heart Structure and Function. CIRCULATION. vol. 132,
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al.(2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest vol. 124, (9) 4039-4051.
10.1172/JCI74281
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6288
Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ, Hobbs AJ(2014). Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension. Circulation vol. 130, (6) 496-507.
10.1161/CIRCULATIONAHA.114.009751
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ(2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol vol. 171, (14) 3463-3475.
10.1111/bph.12694
https://qmro.qmul.ac.uk/xmlui/handle/123456789/14814
Hobbs A, Bubb K, Trinder S, Baliga R, MacAllister R (2014). PHOSPHODIESTERASE 2 IS A NOVEL THERAPEUTIC TARGET IN PULMONARY HYPERTENSION. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. vol. 115, 40-41.
Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ et al.(2013). Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum vol. 65, (11) 2928-2939.
10.1002/art.38078
Bubb KJ, Trinder S, Baliga R, MacAllister RJ, Hobbs AJ (2013). Validation Of Phosphodiesterase 2 As A Novel Therapeutic Target In Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 187,
Baliga RS, Macallister RJ, Hobbs AJ(2013). Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application. Handb Exp Pharmacol vol. 218, 477-511.
10.1007/978-3-642-38664-0_19
Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A, Hobbs AJ(2012). Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Circulation vol. 125, (23) 2922-2932.
10.1161/CIRCULATIONAHA.112.100586
Zhang T, Lu X, Arnold P, Liu Y, Baliga R, Huang H, Bauer JA, Liu Y et al.(2012). Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-α expression and improves cardiac function during endotoxemia. Cardiovasc Res vol. 93, (3) 471-479.
10.1093/cvr/cvr346
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham D, Denton C (2012). SYSTEMIC VEGF INHIBITION INDUCES PULMONARY ARTERIAL HYPERTENSION IN A TRANSGENIC MOUSE MODEL OF SCLERODERMA. RHEUMATOLOGY. vol. 51, 41-41.
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham DJ, Denton CP (2011). Intermittent Systemic VEGF Inhibition Induces Pulmonary Arterial Hypertension In a Transgenic Mouse Model of Scleroderma. ARTHRITIS AND RHEUMATISM. vol. 63, S1022-S1023.
Baliga RS, MacAllister RJ, Hobbs AJ(2011). New perspectives for the treatment of pulmonary hypertension. Br J Pharmacol vol. 163, (1) 125-140.
10.1111/j.1476-5381.2010.01164.x
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton C (2011). AN EXPLORATION OF PULMONARY VASCULAR VEGF SIGNALLING IN A TGF beta-DEPENDENT MOUSE MODEL OF SYSTEMIC SCLEROSIS. RHEUMATOLOGY. vol. 50, 134-135.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2011). Protective Role Of Natriuretic Peptides In Pulmonary Fibrosis: A Novel Therapeutic Target?. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 183,
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton CP(2010). Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis. CLIN EXP RHEUMATOL vol. 28, (5) S63-S63.
Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M, Hobbs AJ(2010). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. Br J Pharmacol vol. 160, (8) 2045-2054.
10.1111/j.1476-5381.2010.00830.x
Derrett-Smith EC, Baliga R, Dooley A, Khan K, Shi-Wen X, Abraham D, Denton CP (2010). FIBROBLAST-SPECIFIC ACTIVATION OF TGF beta IN VIVO RECAPITULATES A HYPOXIC PULMONARY HYPERTENSION PHENOTYPE IN MICE. RHEUMATOLOGY. vol. 49, I112-I113.
Derrett-Smith E, Baliga R, Khan K, Shi-Wen X, Abraham D, Denton C(2010). FIBROBLAST-SPECIFIC ACTIVATION OF TGF-BETA IN MICE RECAPITULATES A HYPOXIC PULMONARY HYPERTENSION PHENOTYPE. CLIN EXP RHEUMATOL vol. 28, (2) S106-S106.
Han B, Baliga R, Huang H, Giannone PJ, Bauer JA(2009). Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol vol. 297, (2) H829-H835.
10.1152/ajpheart.00222.2009
Chaves AA, Joshi MS, Coyle CM, Brady JE, Dech SJ, Schanbacher BL, Baliga R, Basuray A et al.(2009). Vasoprotective endothelial effects of a standardized grape product in humans. Vascul Pharmacol vol. 50, (1-2) 20-26.
10.1016/j.vph.2008.08.004
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ et al.(2008). Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. Am J Respir Crit Care Med vol. 178, (8) 861-869.
10.1164/rccm.200801-121OC
Marro ML, Peiro C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW, Hobbs AJ(2008). Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor. J BIOL CHEM vol. 283, (29) 20027-20036.
10.1074/jbc.M801223200
Luce WA, Huang H, Baliga R, Gannone PJ, Liu Y, Bauer JA (2007). Role of mitogen activated protein kinase phosphatase-1 (MKP-1) in endotoxin-induced cardiac dysfunction. CIRCULATION. vol. 116, 6-6.
Baliga R, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ (2007). Selective modulation of ANP-dependent dilation in the pulmonary vasculature by PDE 5 inhibitors: A novel combination therapy for pulmonary hypertension?. CIRCULATION. vol. 116, 456-456.
Luce WA, Huang H, Baliga R, Giannone PJ, Liu Y, Bauer JA (2007). Deficiency of mitogen activated protein kinase phosphatase-1 (mkp-1) causes enhanced impairment of cardiac function after endotoxin exposure. PEDIATRIC RESEARCH. vol. 62, 517-517.
Han B, Baliga RS, Huang H, Cook AC, Joshi MS, Schanbacher BL, Bauer JA (2007). Alterations in cardiac connexin 43 and microvessel prevalence with ventricular performance deficits during murine diabetic cardiornyopathy. FASEB JOURNAL. vol. 21, A436-A436.
Huang H, Baliga R, Wang XX, Han B, Luce W, Joshi M, Nelin L, Liu Y et al. (2007). Mitogen activated protein kinase phosphatase-1 plays an important role in sepsis-related cardiac dysfunction. FASEB JOURNAL. vol. 21, A804-A804.
Liu YS, Zhao Q, Wang XX, Nelin LD, Yao YX, Chang CH, Baliga R, Meng XM et al. (2006). MAP kinase phosphatase-1 controls innate immune responses and suppresses endotoxic shock. FASEB JOURNAL. vol. 20, A1377-A1377.
Han B, Baliga R, Schanbacher B, Bauer JA (2006). Oxidant modulation of cardiac function: Inhibition of glutathione biosynthesis alters cardiac performance in mice. FASEB JOURNAL. vol. 20, A322-A322.
Chaves AA, Baliga RS, Mihm MJ, Schanbacher BL, Basuray A, Liu C, Cook AC, Ayers LW et al.(2006). Bacterial lipopolysaccharide enhances cardiac dysfunction but not retroviral replication in murine AIDS: roles of macrophage infiltration and toll-like receptor 4 expression. Am J Pathol vol. 168, (3) 727-735.
10.2353/ajpath.2006.050794
Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, Baliga RS, Meng X et al.(2006). MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med vol. 203, (1) 131-140.
10.1084/jem.20051794
Baliga RS, Chaves AA, Jing L, Ayers LW, Bauer JA(2005). AIDS-related vasculopathy: evidence for oxidative and inflammatory pathways in murine and human AIDS. Am J Physiol Heart Circ Physiol vol. 289, (4) H1373-H1380.
10.1152/ajpheart.00304.2005
Malik F, Elias KA, Finer JT, Morgan BP, Sakowicz R, Anderson R, Baliga R, Conn L et al. (2005). Direct activation of cardiac myosin by CK-1827452 improves cardiac function in a dog heart failure model. JOURNAL OF CARDIAC FAILURE. vol. 11, S95-S95.
Baliga RS, Carnes CA, Cook AC, Bauer JA (2004). Characterization of diabetic cardiomyopathy development in a mouse streptozotocin model: Reasons and consequences. PEDIATRIC RESEARCH. vol. 55, 153A-153A.
Baliga RS, Carnes CA, Hamlin RL, Nakayama T, Bauer JA (2004). Reactive nitrogen species in a dog model of mitral regurgitation: Sources and consequences. PEDIATRIC RESEARCH. vol. 55, 589A-589A.
Baliga RS, Mihm MJ, Carnes CA, McCarthy PM, Van Wagoner DR, Bauer JA (2004). Chronic human atrial fibrillation - Immune infiltration and endothelial activation. FASEB JOURNAL. vol. 18, A230-A230.
Baliga RS, Carnes CA, Bauer JA (2004). Diabetic cardiomyopathy in a mouse streptozotocin model. FASEB JOURNAL. vol. 18, A576-A576.
Baliga RS, Carnes CA, Cook AC, Bauer JA (2004). Mitral regurgitation - Roles of reactive nitrogen species and immune infiltrates. FASEB JOURNAL. vol. 18, A602-A603.
Bauer JA, Baliga RS, Mihm MJ, Cook AC, McCarthy PM, Carnes CA, VanWagoner DR (2004). Reactive nitrogen species formation during chronic human atrial fibrillation: Sources and consequences. FASEB JOURNAL. vol. 18, A603-A603.
Chaves AA, Mihm MJ, Basuray A, Baliga R, Ayers LW, Bauer JA(2004). HIV/AIDS-related cardiovascular disease. Cardiovasc Toxicol vol. 4, (3) 229-242.
10.1385/ct:4:3:229
Baliga RS, Liu C, Hoyt DG, Chaves AA, Bauer JA(2004). Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis. Cardiovasc Toxicol vol. 4, (2) 199-206.
10.1385/ct:4:2:199
Baliga RS, Lui C, Jing L, Chaves AA, Bauer JA (2003). Time dependent vascular dysfunction in murine AIDS: Evidence for involvement of reactive nitrogen species. PEDIATRIC RESEARCH. vol. 53, 558A-558A.
Pitre-Poladia D, Baliga R, Bauer JA (2003). Urinary bladder dysfunction during diabetes: Functional, structural, and neuronal investigations of a mouse model. PEDIATRIC RESEARCH. vol. 53, 135A-135A.
Chaves AA, Coyle CM, Brady JE, Dech SJ, Joshi MS, Schanbacher BL, Basuray A, Baliga RS et al. (2003). Vascular endothelial effects of a standardized grape product in humans. PEDIATRIC RESEARCH. vol. 53, 559A-559A.
Baliga RS, Liu C, Chaves AA, Jing L, Bauer JA (2003). Mechanistic studies in a mouse model of AIDS related vasculopathy: involvement of reactive nitrogen species. FASEB JOURNAL. vol. 17, A650-A650.
Chaves AA, Coyle CM, Brady JE, Dech SJ, Joshi MS, Schanbacher BL, Baliga R, Basuray A et al. (2003). Vasoprotective effects of a standardized grape product in humans. FASEB JOURNAL. vol. 17, A237-A237.
Bauer JA, Baliga RS, Liu CY, Jones C, Hoyt DG(2002). Endothelial toxicity induced by HIV protease inhibitors: Evidence of oxidant related dysfunction and apoptosis. PEDIATRIC RESEARCH vol. 51, (4) 465A-465A.
Baliga RS, Carnes CA, Chung MK, Nakayama H, Nakayama T, Piao S, Kanderian A, Pavia S et al.(2002). Ascorbate attenuates atrial pacing-induced peroxynitrite formation, electrical remodeling and the incidence of post-operative atrial fibrillation. FASEB JOURNAL vol. 16, (4) A176-A177.
Carnes CA, Chung MK, Nakayama T, Nakayama H, Baliga RS, Piao S, Kanderian A, Pavia S et al.(2001). Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ Res vol. 89, (6) E32-E38.
10.1161/hh1801.097644
Kubota I, Han X, Opel DJ, Zhao YY, Baliga R, Huang P, Fishman MC, Shannon RP et al.(2000). Increased susceptibility to development of triggered activity in myocytes from mice with targeted disruption of endothelial nitric oxide synthase. J Mol Cell Cardiol vol. 32, (7) 1239-1248.
10.1006/jmcc.2000.1158
Liu CY, Jones C, Chaves AA, Baliga R, Hoyt D, Bauer JA(2000). HIV protease inhibitors promote endothelial dysfunction and oxidant formation. FASEB J vol. 14, (8) A1563-A1563.
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