Publications: Prof Andrew Tinker

Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD, Munroe PB ( 2024 ) . Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease . European Heart Journal vol. 45 , ( Supplement_1 )

Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB et al. ( 2024 ) . Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal . European Heart Journal vol. 45 , ( Supplement_1 )

Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ et al. ( 2024 ) . The genetic architecture of exercise-induced ventricular ectopy . European Heart Journal vol. 45 , ( Supplement_1 )

Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al. ( 2024 ) . Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants . Journal of the American Heart Association vol. 13 , ( 17 )

Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S et al. ( 2024 ) . Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation . Nature Cardiovascular Research vol. 3 , ( 9 ) 1067 - 1082 .

Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al. ( 2024 ) . Fine mapping of candidate effector genes for heart rate . Human Genetics vol. 143 , ( 9-10 ) 1207 - 1221 .

Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB, Tinker A ( 2024 ) . The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart . Journal of Biological Chemistry vol. 300 , ( 7 )

Brennan S, Chen S, Makwana S, Esposito S, McGuinness LR, Alnaimi AIM, Sims MW, Patel M et al. ( 2024 ) . Identification and characterisation of functional Kir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane . British Journal of Pharmacology vol. 181 , ( 18 ) 3380 - 3400 .

Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Del Arroyo AG, Crescente M, Tinker A et al. ( 2024 ) . Transcriptional response of the heart to vagus nerve stimulation . Physiol Genomics vol. 56 , ( 2 ) 167 - 178 .

Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A et al. ( 2023 ) . Transcriptional response of the heart to vagus nerve stimulation . Physiol Genomics

Ramírez J, Miguel A, van Duijvenboden S, Orini M, Young WJ, Tinker A, Lambiase PD, Munroe PB et al. ( 2023 ) . A Multilayer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Orini M, van Duijvenboden S, Ramírez J, Young W, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals Without Cardiovascular Disease . 2016 Computing in Cardiology Conference (CinC) . Conference: 2023 Computing in Cardiology Conference (CinC) vol. 50 , 1 - 4 .

Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB, Miguel A ( 2023 ) . Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population . European Heart Journal vol. 44 , ( Supplement_2 )

Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease . European Heart Journal vol. 44 , ( Supplement_2 )

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB et al. ( 2023 ) . Long-term association of ultra-short heart rate variability with cardiovascular events . Scientific Reports vol. 13 , ( 1 )

Sanpawithayakul K, Mistry A, Rai A, Funge G, Sebastian S, Solomou A, Lillina VM, Gaston-Massuet C et al. ( 2023 ) . Hindering the progression of cardiac fibrosis in acromegaly - the role of somatostatin receptor ligands . Endocrine Abstracts

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al. ( 2023 ) . GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway . Cell Reports vol. 42 , ( 11 )

van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB et al. ( 2023 ) . Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects . Circulation vol. 148 , ( 24 ) 1932 - 1944 .

Specterman MJ, Aziz Q, Li Y, Anderson NA, Ojake L, Ng K-E, Thomas AM, Finlay MC et al. ( 2023 ) . Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels . Circulation Arrhythmia and Electrophysiology vol. 16 , ( 9 )

Williams JL, Smith CJ, Mastroianni G, Stewart M, Cutillas P, Tinker A, Metherell L ( 2023 ) . Abstract P2043: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A Myl2-independent Mechanism . Circulation Research vol. 133 , ( Suppl_1 )

Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL, Gourine AV ( 2023 ) . Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training . Cardiovascular Research vol. 119 , ( 13 ) 2329 - 2341 .

Williams J, Stewart M, Tinker A, Cutillas P, Metherell L ( 2023 ) . BS18 Loss of full-length MYLK3 causes dilated cardiomyopathy via a MYL2-independent mechanism . Conference: Basic Sciencea258 - a259 .

Frost S, Parey E, Tinker A, Villar D ( 2023 ) . BS47 A comparative genomics approach reveals the interplay between epigenomic enhancer conservation and common genetic variation in the heart . Conference: Basic Sciencea279.2 - a2a279 .

Rodriguez A, Villar D, Frost S, Tinker A, Thomas A ( 2023 ) . BS56 An epigenomic investigation of atrial fibrillation in a paired left and right atrial cohort . Conference: Basic Sciencea285.1 - a2a285 .

Fernández-Aroca D, Frost S, Tikkas G, Rodriguez A, Tinker A, Villar D ( 2023 ) . BS69 Characterisation of in vivo and in vitro models for epigenomic investigations of cardiac hypertrophy . Conference: Basic Sciencea296.1 - a2a296 .

Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F et al. ( 2023 ) . Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools . Nature Communications vol. 14 , ( 1 )

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al. ( 2023 ) . Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease . Nature Communications vol. 14 , ( 1 )

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB, Lambiase PD ( 2023 ) . Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events . European Heart Journal - Digital Health vol. 4 , ( 2 ) 112 - 118 .

Orini M, van Duijvenboden S, Tinker A, Munroe P, Lambiase P ( 2022 ) . Association Between Photoplethysmography Pulse Upslope and Cardiovascular Events in over 170,000 UK Biobank Participants . 2016 Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Orini M, van Duijvenboden S, Ramírez J, Tinker A, Munroe P, Lambiase P ( 2022 ) . Uncoupling Between Heart Rate Variability and Heart Rate During Exercise and Recovery as a Predictor of Cardiovascular Events . 2016 Computing in Cardiology Conference (CinC) . Conference: 2022 Computing in Cardiology Conference (CinC) vol. 498 , 1 - 4 .

Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell GS et al. ( 2022 ) . Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels . Frontiers in Physiology vol. 13 ,

Kwek X-Y, Hall AR, Lim W-W, Katwadi K, Soong PL, Grishina E, Lin K-H, Crespo-Avilan G et al. ( 2022 ) . Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion . Scientific Reports vol. 12 , ( 1 )

Wilson D, Tinker A, Iskratsch T ( 2022 ) . Investigating cardiomyocyte dysfunction in dilated cardiomyopathy associated with Duchenne muscular dystrophy . Journal of Molecular and Cellular Cardiology vol. 173 ,

Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al. ( 2022 ) . CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model . Neuromuscular Disorders

Sebastian S, Weinstein LS, Ludwig A, Munroe P, Tinker A ( 2022 ) . Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy . Function vol. 4 , ( 1 )

Iskratsch T, Wilson D, Tinker A ( 2022 ) . The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction . Communications Biology

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 )

Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV et al. ( 2022 ) . ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations . Journal of the American Heart Association vol. 11 , ( 17 )

Williams JL, Paudyal A, Stewart M, Cutillas P, Tinker A, Metherell L ( 2022 ) . Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism . Circulation Research vol. 131 , ( Suppl_1 ) ap2005 - ap2005 .

Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P ( 2022 ) . Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors . Atherosclerosis vol. 355 , 3 - 4 .

Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors . Circulation Genomic and Precision Medicine vol. 15 , ( 5 ) e003441 - e003441 .

Jones A, Tinker A ( 2022 ) . BS11 Novel T-type calcium current pharmacology shows promise in the study of atrial fibrillation . Conference: Basic sciencea150.1 - a1a150 .

Tinker A, Aziz Q, Li Y ( 2022 ) . ATP-Dependent K+ Channels . Encyclopedia of Molecular Pharmacology , Springer Nature

Olczak K, Aziz Q, Sebastian S, Rajeeve V, Otunsola R, Tinker A, Munroe P ( 2022 ) . Investigating the potential role of R-Ras in blood pressure control . JOURNAL OF HUMAN HYPERTENSION . vol. 36 , 2 - 3 .

Olczak KJ, Aziz Q, Sebastian S, Tinker A, Munroe PB ( 2022 ) . Investigating the potential role of the small GTPase R-Ras in mechanisms of blood pressure control . ACTA PHYSIOLOGICA . vol. 236 , 543 - 543 .

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of coronary artery disease: Do risk factor genetic risk scores add value? . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 30 , 188 - 189 .

Bercea CI, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell G et al. ( 2022 ) . The role of ATP-sensitive potassium channels in omega-3 polyunsaturated fatty acid-mediated vasodilation in mouse aorta and mesenteric arteries . ACTA PHYSIOLOGICA . vol. 236 , 565 - 567 .

Christensen SL, Rasmussen RH, La Cour S, Ernstsen C, Hansen TF, Kogelman LJ, Lauritzen SP, Guzaite G et al. ( 2021 ) . Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models . Cephalalgia vol. 42 , ( 2 ) 93 - 107 .

Williams J, paudyal A, Stewart M, Cutillas P, Cox RD, Tinker A, Metherell L ( 2021 ) . Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice . Circulation vol. 144 , ( Suppl_1 ) a14037 - a14037 .

Mistry A, Funge G, Sebastian S, Aziz Q, Solomou A, Vignola ML, Thong LC, Herincs M et al. . Acromegalic cardiomyopathy in pituitary-specific aryl hydrocarbon receptor interacting protein (Aip) gene knockout animals . Endocrine Abstracts .

Tinker A ( 2021 ) . Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification? . European Heart Journal vol. 42 , ( 46 ) 4756 - 4758 .

Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P, Tinker A ( 2021 ) . B-PO02-015 ENHANCING MUTANT I KSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY . Heart Rhythm vol. 18 , ( 8 )

van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB ( 2021 ) . Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders . Human Molecular Genetics vol. 30 , ( 24 ) 2513 - 2523 .

Li Y, Aziz Q, Tinker A ( 2021 ) . The Pharmacology of ATP-Sensitive K+ Channels (KATP) . Handbook of Experimental Pharmacology vol. 267 , 357 - 378 .

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al. ( 2021 ) . Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy . Cell and Tissue Research vol. 386 , ( 1 ) 79 - 98 .

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A ( 2021 ) . Analysing electrocardiographic traits and predicting cardiac risk in UK biobank . JRSM Cardiovascular Disease vol. 10 ,

van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe P, Lambiase P ( 2021 ) . 85 Prognostic value of premature ventricular complexes during exercise stress testing in 56,000 individuals without known structural heart disease from UK biobank: is a single ectopic prognostic? . Heart . Conference: Cardiac rhythm management vol. 107 , a68 - a68 .

Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .

Rathod V, Harmer S, Royal A, Aziz Q, Lambiase P, Tinker A ( 2021 ) . Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway . EP Europace vol. 23 , ( Supplement_3 )

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization . Circulation Genomic and Precision Medicine vol. 14 , ( 3 )

Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A ( 2021 ) . The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate . Physiological Genomics vol. 53 , ( 4 ) 150 - 159 .

Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al. ( 2021 ) . No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis . Frontiers in Genetics vol. 12 ,

Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2021 ) . Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors . GENETIC EPIDEMIOLOGY . vol. 45 , 783 - 783 .

Young WJ, Srinivasan N, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Comparisons of the Spatial QRS-T Angle With Intra-cardiac Markers of Depolarization and Repolarization . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

van Duijvenboden S, Ramírez J, Young WJ, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Sex Differences in the Morphology of RR-Matched T-waves . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Young WJ, Ramírez J, van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice? . 2016 Computing in Cardiology Conference (CinC) . Conference: 2020 Computing in Cardiology Conference (CinC) vol. 00 , 1 - 4 .

Ramírez J, Tinker A ( 2020 ) . Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses . Function vol. 2 , ( 1 )

Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs . Biomedical Signal Processing and Control vol. 64 ,

Ramirez J, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Interaction between ECG and Genetic Markers of Coronary Artery Disease . Computing in Cardiology . Conference: CinC 2020 from: 13/09/2020 to: 16/09/2020 , vol. 2020-September ,

Balestrini S, Mikati MA, Garcia-Roves RA, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L et al. ( 2020 ) . Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study . Neurology

Li Y, Aziz Q, Anderson N, Ojake L, Tinker A ( 2020 ) . Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis . HypertensionHYPERTENSIONAHA12015 - HYPERTENSIONAHA12015 .

Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al. ( 2020 ) . Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia . Journal of Molecular Medicine

Villar D, Frost S, Deloukas P, Tinker A ( 2020 ) . The contribution of non-coding regulatory elements to cardiovascular disease . Open Biology vol. 10 , ( 7 ) 200088 - 200088 .

Aziz Q, Tinker A ( 2020 ) . The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on "The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome" . Function vol. 1 , ( 1 ) zqaa005 - zqaa005 .

van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2020 ) . Genetic Basis and Prognostic Value of Exercise QT Dynamics . Circulation Genomic and Precision Medicine vol. 13 , ( 4 ) e002774 - e002774 .

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A ( 2020 ) . Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval . American Journal of Human Genetics vol. 106 , ( 6 ) 764 - 778 .

Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV et al. ( 2020 ) . Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not . Life Science Alliance vol. 3 , ( 4 )

Tinker A, Aziz Q, Li Y ( 2020 ) . ATP-Dependent K + Channels . Encyclopedia of Molecular Pharmacology , Springer Nature

Aziz Q, Nobles M, Tinker A ( 2020 ) . Acute Isolation of Cells from Murine Sino-atrial Node . Bio-protocol vol. 10 , ( 1 )

Aziz Q, Nobles M, Tinker A ( 2020 ) . Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells . Bio-protocol vol. 10 , ( 1 )

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M et al. ( 2019 ) . Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics . Circulation: Arrhythmia and Electrophysiology vol. 12 , ( 10 ) e007549 - e007549 .

Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A, Munroe PB ( 2019 ) . Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function . Human Molecular Genetics vol. 29 , ( 11 ) 1797 - 1807 .

Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al. ( 2019 ) . Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages . Physiol Genomics vol. 51 , ( 8 ) 323 - 332 .

Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA et al. ( 2019 ) . Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome . Am J Physiol Cell Physiol

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al. ( 2019 ) . Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals . Journal of the American College of Cardiology vol. 73 , ( 24 ) 3118 - 3131 .

Ramirez J, van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB ( 2019 ) . 21 The cardiovascular predictive value and genetic basis of T-wave morphology . Heart . Conference: Cardiac rhythm management vol. 105 ,

van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe PB, Lambiase P ( 2019 ) . 22 Cardiac repolarization during exercise reveals independent prognostic information for cardiovascular risk prediction . Heart . Conference: Cardiac Rhythm Management vol. 105 ,

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . DSP mutations and arrhythmogenic cardiomyopathy . British Journal of Dermatology vol. 180 , ( 5 ) e157 - e157 .

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . DSP 突变与致心律失常性心肌病 . British Journal of Dermatology vol. 180 , ( 5 ) e169 - e169 .

Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A et al. ( 2019 ) . Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D . Front Physiol vol. 10 , 259 - 259 .

Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A, Schilling RJ ( 2019 ) . Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method . Journal of Cardiovascular Electrophysiology vol. 30 , ( 5 ) 691 - 701 .

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al. ( 2019 ) . Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype . British Journal of Dermatology vol. 180 , ( 5 ) 1114 - 1122 .

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2019 ) . CRISPR/Cas9 genome editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy . HUMAN GENE THERAPY . vol. 30 , A5 - A5 .

Balestrini S, Mikati M, Garcia-Roves RA, Carboni M, Hunanyan A, Kherallah B, McLean M, Prange L et al. ( 2019 ) . Cardiac Phenotype In <i>ATP1A3</i> Related-Syndromes: A Multicentre Study . EPILEPSIA . vol. 60 , 173 - 173 .

Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2019 ) . Identification of novel loci for heart rate response to exercise and recovery . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 27 , 135 - 135 .

Scott ES, Awford J, Hyde R, Hassan M, Hashmi L, Harmer S, Fischer P, Kellam B et al. ( 2019 ) . Using bioluminescent hiPSC reporter lines and high content screening to identify novel compounds for cardiomyocyte maturation . HUMAN GENE THERAPY . vol. 30 , A8 - A8 .

Aziz Q, Li Y, Tinker A ( 2018 ) . Potassium channels in the sinoatrial node and their role in heart rate control . Channels vol. 12 , ( 1 ) 356 - 366 .

Ramírez J, van Duijvenboden S, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . 23T-wave morphology restitution predicts arrhythmic risk in the UK biobank cohort . EP Europace vol. 20 , ( suppl_4 ) iv10 - iv11 .

van Duijvenboden S, Ramírez J, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . 2QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure . EP Europace vol. 20 , ( suppl_4 ) iv1 - iv1 .

Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M et al. ( 2018 ) . Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1) . Circ Arrhythm Electrophysiol vol. 11 , ( 10 ) e006740 - e006740 .

Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A, Scambler PJ ( 2018 ) . Defective Vagal Innervation in Murine Tbx1 Mutant Hearts . Journal of Cardiovascular Development and Disease vol. 5 , ( 4 )

Tinker A, Aziz Q, Li Y, Specterman M ( 2018 ) . ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles . vol. 8 , ( 4 ) 1463 - 1511 .

Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA et al. ( 2018 ) . Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome . Circ Arrhythm Electrophysiol vol. 11 , ( 9 ) e006330 - e006330 .

Ramirez J, Van Duijvenboden S, Laguna P, Pueyo E, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2018 ) . Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology . Computing in Cardiology . Conference: Computing in Cardiology ( Maastricht, The Netherlands ) from: 23/09/2018 to: 26/09/2018 , vol. 2018-September ,

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . European Heart Journal vol. 39 , ( suppl_1 )

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al. ( 2018 ) . Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 . Genome Biology vol. 19 , ( 1 )

Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA et al. ( 2018 ) . A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow . Journal of Cerebral Blood Flow and Metabolism

Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. ( 2018 ) . Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system . Nature Communications vol. 9 , ( 1 )

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2018 ) . CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy . European Heart Journal vol. 39 , ( 43 ) 3879 - 3892 .

Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A ( 2018 ) . ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia . Journal of Biological Chemistry vol. 293 , ( 23 ) 8912 - 8921 .

Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD, Tinker A ( 2018 ) . P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation . EP Europace vol. 20 , ( suppl_1 ) i87 - i87 .

Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A et al. ( 2018 ) . p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response . Nature Communications vol. 9 , ( 1 )

Tinker A, Finlay M, Nobles M, Opel A ( 2018 ) . Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61] . Pharmacological Research vol. 129 ,

Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE et al. ( 2018 ) . Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology . Circ Genom Precis Med vol. 11 , ( 2 ) e001813 - e001813 .

Orini M, Tinker A, Munroe PB, Lambiase PD ( 2018 ) . Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLoS One vol. 13 , ( 2 ) e0193039 - e0193039 .

Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A ( 2018 ) . Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria . American Journal of Physiology - Cell Physiology vol. 314 , ( 5 ) c616 - c626 .

Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al. ( 2018 ) . Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths . Circulation Genomic and Precision Medicine vol. 11 , ( 1 )

Aziz Q, Li Y, Tinker A ( 2018 ) . Endothelial biology and ATP-sensitive potassium channels . Channels vol. 12 , ( 1 ) 45 - 46 .

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. ( 2018 ) . CRISPR/Cas9 gene editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy . HUMAN GENE THERAPY . vol. 29 , A93 - A94 .

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. ( 2018 ) . Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker . EUROPEAN HEART JOURNAL . vol. 39 , 1206 - 1206 .

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al. ( 2017 ) . Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters . Stem Cell Research vol. 25 , 233 - 244 .

TINKER A, Lane J D ( 2017 ) . Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? . Frontiers in Physiology vol. 8 ,

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV et al. ( 2017 ) . Mammalian γ2 AMPK regulates intrinsic heart rate . Nat Commun vol. 8 , ( 1 ) 1258 - 1258 .

Royal AA, Tinker A, Harmer SC ( 2017 ) . Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking . PLoS One vol. 12 , ( 10 ) Article 0186293 , e0186293 - e0186293 .

Lane JD, Montaigne D, Tinker A ( 2017 ) . Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation . vol. 250 , is. 5 , pp. 471 - 481 . Springer Nature

Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E, Tinker A ( 2017 ) . Molecular and functional characterization of the endothelial ATP-sensitive potassium channel . Journal of Biological Chemistry vol. 292 , ( 43 ) 17587 - 17597 .

Orini M, Tinker A, Munroe PB, Lambiase PD ( 2017 ) . Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort . PLoS One vol. 12 , ( 9 ) e0183732 - e0183732 .

Tinker A ( 2017 ) . The mechanisms of ventricular arrhythmia in Chagas disease . International Journal of Cardiology vol. 240 , 372 - 373 .

Munroe PB, Tinker A ( 2017 ) . Heritability of resting heart rate and association with mortality in middle-aged and elderly twins . Heart vol. 104 , ( 1 ) 6 - 7 .

Zhang Y, Marrion N, Harmer S, Mohamed R, Tinker A, Hancox J ( 2017 ) . 227hERG potassium channel modulation by P127T KCNE1 . EP Europace vol. 19 , ( suppl_3 ) iii22 - iii22 .

Cartwright J, Aziz Q, Harmer S, Tinker A, Munroe P ( 2017 ) . Functional Studies of TRPM7-a Candidate Gene for Stillbirth? . FASEB JOURNAL . Conference: EB vol. 31 ,

MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP ( 2017 ) . Discovery of novel heart rate-associated loci using the exome chip . Human Molecular Genetics

Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al. ( 2017 ) . Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells . Molecular and Cellular Endocrinology vol. 447 , 12 - 22 .

Finlay M, Harmer SC, Tinker A ( 2017 ) . The control of cardiac ventricular excitability by autonomic pathways . Pharmacology & Therapeutics vol. 174 , 97 - 111 .

Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R et al. ( 2016 ) . ORAL ABSTRACTS (1) . EP Europace vol. 18 , ( suppl_2 ) ii4 - ii7 .

Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B et al. ( 2016 ) . YOUNG INVESTIGATORS COMPETITION . EP Europace vol. 18 , ( suppl_2 ) ii1 - ii3 .

MUNROE PB ( 2016 ) . Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension . Nature Genetics

Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A ( 2016 ) . The role of GαO‐mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability . Physiological Reports vol. 4 , ( 15 )

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al. ( 2016 ) . GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway . Cell Rep vol. 16 , ( 4 ) 1026 - 1038 .

Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A ( 2016 ) . Loss of the inhibitory GalphaO protein in the rostral ventrolateral medulla of the brainstem leads to abnormalities in cardiovascular reflexes and altered ventricular excitablitiy . CARDIOVASCULAR RESEARCH . Conference: ESC meeting vol. 111 , S98 - S98 .

Zhou X, Harmer S, Bueno-Orovio A, Burrage K, Tinker A, Rodriguez B ( 2016 ) . 57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation? . EP Europace vol. 18 , ( suppl_1 ) i167 - i167 .

Harmer SC, Tinker A ( 2016 ) . The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes . Biol Chem vol. 397 , ( 7 ) 679 - 693 .

Tinker A, Finlay M, Nobles M, Opel A ( 2016 ) . The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation . Pharmacological Research vol. 105 , 54 - 61 .

Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A, Baker JR ( 2016 ) . Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines . Organic & Biomolecular Chemistry vol. 14 , ( 2 ) 455 - 459 .

Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB et al. ( 2015 ) . Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop . EP Europace vol. 18 , ( 9 ) 1287 - 1298 .

Munroe PB, Tinker A ( 2015 ) . Genome-wide association studies and contribution to cardiovascular physiology . Physiological Genomics vol. 47 , ( 9 ) 365 - 375 .

Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A, Hussain K ( 2015 ) . Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8 . Human Molecular Genetics vol. 24 , ( 18 ) 5142 - 5153 .

Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R, Tinker A ( 2015 ) . Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling* . Journal of Biological Chemistry vol. 290 , ( 31 ) 19233 - 19244 .

Yeoh A, Finlay M, Anderson N, Harmer S, Tinker A ( 2015 ) . 162 Simultaneous measurement of calcium transients and electrical activity in murine cardiac tissue – a novel system for the study of cardiac arrhythmia . Heart . vol. 101 ,

Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A et al. ( 2015 ) . Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve . Heart Rhythm vol. 12 , ( 11 ) 2285 - 2293 .

Aziz Q, Li Y, Tinker A ( 2015 ) . ATP-sensitive potassium channels and vascular function . Channels vol. 9 , ( 1 ) 3 - 4 .

Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA et al. ( 2015 ) . iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 9 ) e973 - e981 .

Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A, Baker JR ( 2015 ) . A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging . Organic & Biomolecular Chemistry vol. 13 , ( 37 ) 9559 - 9563 .

Machhada A, Ang R, Ackland G, Ninkina N, Buchman V, Lythgoe MF, Trapp S, Tinker A et al. ( 2015 ) . Reduced activity of dorsal vagal preganglionic neurones associated with synuclein pathology predisposes the heart to ventricular arrhythmia . EUROPEAN HEART JOURNAL . vol. 36 , 215 - 215 .

Arya VB, Aziz Q, Nessa A, Tinker A, Hussain K ( 2014 ) . Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy . International Journal of Pediatric Endocrinology vol. 2014 , ( 1 )

Lambiase PD, Tinker A ( 2014 ) . Connexins in the heart . Cell and Tissue Research vol. 360 , ( 3 ) 675 - 684 .

Lane JD, Abramowitz J, Birnbaumer L, Tinker A ( 2014 ) . 51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure . Europace vol. 16 Suppl 3 ,

Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L et al. ( 2014 ) . The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control . Hypertension vol. 64 , ( 3 ) 523 - 529 .

Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD, Tinker A ( 2014 ) . Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1 . Biochem J vol. 462 , ( 1 ) 133 - 142 .

Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A, Baker JR ( 2014 ) . Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents . ORGANIC & BIOMOLECULAR CHEMISTRY vol. 12 , ( 4 ) 557 - 560 .

Tinker A, Aziz Q, Thomas A ( 2014 ) . The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system . Br J Pharmacol vol. 171 , ( 1 ) 12 - 23 .

Tinker A, Harmer SC ( 2013 ) . Potassium channels regulating the electrical activity of the heart . Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment , vol. 9780857299208 ,

Ang R, Birnbaumer L, Gourine AV, Tinker A ( 2013 ) . The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart . European Heart Journal vol. 34 , ( suppl_1 )

Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L, Tinker A ( 2013 ) . The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins . Am J Physiol Regul Integr Comp Physiol vol. 305 , ( 4 ) R435 - R442 .

Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA ( 2013 ) . A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂ . PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY vol. 465 , ( 7 ) 945 - 953 .

Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA ( 2013 ) . Essential Role of the m₂R-RGS6-I_KACh Pathway in Controlling Intrinsic Heart Rate Variability . PLOS ONE vol. 8 , ( 10 ) Article ARTN e76973 ,

Ang R, Birnbaumer L, Gourine A, Tinker A ( 2013 ) . THE ROLE OF INHIBITORY G PROTEIN GALPHAO-MEDIATED SIGNALLING IN THE CENTRAL NERVOUS MECHANISMS CONTROLLING SYMPATHETIC OUTFLOW TO THE HEART . HEART . vol. 99 , A121 - A121 .

Ang R, Birnbaumer L, Gourine AV, Tinker A ( 2013 ) . The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart . EUROPEAN HEART JOURNAL . vol. 34 , 928 - 928 .

Schwarzer S, Mashanov GI, Molloy JE, Tinker A ( 2013 ) . Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly . Methods Mol Biol vol. 998 , 201 - 208 .

Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H et al. ( 2012 ) . Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3 . Circ Res vol. 111 , ( 2 ) e19 - e31 .

Harmer SC, Mohal JS, Kemp D, Tinker A ( 2012 ) . Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel . Biochem J vol. 443 , ( 3 ) 635 - 642 .

Tinker A ( 2012 ) . The assembly and targeting of potassium channels . Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels ,

Aziz Q, Thomas AM, Khambra T, Tinker A ( 2012 ) . Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C . J Biol Chem vol. 287 , ( 9 ) 6196 - 6207 .

Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M et al. ( 2012 ) . Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study . Eur Heart Journal vol. 33 , ( 15 ) 1942 - 1953 .

Ang R, Sebastian S, Ludwig A, Birnbaumer L, Tinker A ( 2012 ) . Mice with conditional knockout of Galphai2 in the cardiac pacemaker system exhibit tachycardia with loss of HF power on HRV analysis . CARDIOVASCULAR RESEARCH . vol. 93 , S20 - S20 .

Aziz Q, Khambra T, Sones W, Thomas AM, Kotlikoff M, Tinker A ( 2012 ) . Mouse model for the conditional deletion of the KATP channel subunit Kir6.1 in vascular smooth muscle . CARDIOVASCULAR RESEARCH . vol. 93 , S74 - S74 .

Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C ( 2012 ) . NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system . DEVELOPMENTAL BIOLOGY vol. 369 , ( 2 ) 277 - 285 .

Harmer SC, Mohal JS, Kemp D, Tinker A ( 2012 ) . Rescue of long QT syndrome type 1 nonsense mutations by pharmacologically mediated readthrough . CARDIOVASCULAR RESEARCH . vol. 93 , S105 - S105 .

Telezhkin V, Reilly JM, Thomas AM, Tinker A, Brown DA ( 2012 ) . Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding . JOURNAL OF BIOLOGICAL CHEMISTRY vol. 287 , ( 13 ) 10001 - 10012 .

Thomas AM, Aziz Q, Khambra T, Tinker A ( 2012 ) . The KATP channel subunit, Kir6.2, is regulated by a Ca<SUP>2+</SUP>-dependent isoform of Protein Kinase C . CARDIOVASCULAR RESEARCH . vol. 93 , S65 - S65 .

Ang R, Opel A, Tinker A ( 2012 ) . The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias . Frontiers in Physiology vol. 3 ,

Nobles M, Sebastian S, Tinker A ( 2012 ) . The role of RGS4 in the electrophysiology of atrial cardiac myocytes . CARDIOVASCULAR RESEARCH . vol. 93 , S64 - S64 .

Tinker A, Harmer SC ( 2011 ) . Potassium Channels Regulating the Electrical Activity of the Heart . Translational Vascular Medicine , Springer Nature

Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A, Baker JR ( 2011 ) . The design, synthesis and pharmacological characterization of novel β2‐adrenoceptor antagonists . British Journal of Pharmacology vol. 164 , ( 2 ) 317 - 331 .

Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S, Baker JR ( 2011 ) . In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation . Bioconjugate Chemistry vol. 22 , ( 2 ) 132 - 136 .

Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO, Shuba YM ( 2011 ) . Sarcolemmal cardiac KATP channels as a target for the cardioprotective effects of the fluorine‐containing pinacidil analogue, flocalin . British Journal of Pharmacology vol. 162 , ( 3 ) 701 - 711 .

Thomas AM, Harmer SC, Khambra T, Tinker A ( 2011 ) . Characterization of a binding site for anionic phospholipids on KCNQ1 . Journal of Biological Chemistry vol. 286 , 2088 - 2100 .

Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A et al. ( 2011 ) . Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations . Diab tologia vol. 54 , 2575 - 2583 .

Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN et al. ( 2010 ) . In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells . Stem Cell Reviews and Reports vol. 7 , ( 2 ) 364 - 380 .

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW ( 2010 ) . Retraction Note: The large-conductance Ca2+-activated K+ channel is essential for innate immunity . Nature vol. 468 , ( 7320 ) 122 - 122 .

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S ( 2010 ) . ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity . ChemInform vol. 41 , ( 43 ) no - no .

Schwarzer S, Nobles M, Tinker A ( 2010 ) . Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?* . Journal of Biological Chemistry vol. 285 , ( 36 ) 27817 - 27826 .

Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L, Tinker A ( 2010 ) . Absence of the Inhibitory G-Protein G&agr;i2 Predisposes to Ventricular Cardiac Arrhythmia . Circulation Arrhythmia and Electrophysiology vol. 3 , ( 4 ) 391 - 400 .

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S ( 2010 ) . An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity . Chemical Communications vol. 46 , ( 22 ) 3953 - 3954 .

Ng K-E, Schwarzer S, Duchen MR, Tinker A ( 2010 ) . The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1 . The Journal of Membrane Biology vol. 234 , ( 2 ) 137 - 147 .

Nobles M, Sebastian S, Tinker A ( 2010 ) . HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes . Pflügers Archiv - European Journal of Physiology vol. 460 , ( 1 ) 99 - 108 .

Aziz Q, Thomas A, Khambra T, Tinker A ( 2010 ) . Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel . European Journal of Pharmacology vol. 634 , ( 1-3 ) 26 - 32 .

Mashanov GI, Nobles M, Harmer SC, Molloy JE, Tinker A ( 2010 ) . Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior . Journal of Biological Chemistry vol. 285 , 3664 - 3675 .

Tinker A, Harmer SC ( 2010 ) . K+ channels in the heart: new insights and therapeutic implications . Expert Rev Clin Pharmacol vol. 3 , 305 - 319 .

Harmer SC, Wilson AJ, Aldridge R, Tinker A ( 2010 ) . Mechanisms of disease pathogenesis in long QT syndrome type 5 . Am J Physiol Cell Physiol vol. 298 , C263 - C273 .

Orie N, Thomas A, Perrino B, Tinker A, Clapp L ( 2009 ) . Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway . British Journal of Pharmacology vol. 157 , ( 4 ) 554 - 564 .

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI et al. ( 2009 ) . Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice . Journal of Molecular and Cellular Cardiology vol. 47 , ( 1 ) 133 - 141 .

Cui Y, Tinker A, Clapp LH ( 2009 ) . Different molecular sites of action for the KATP channel inhibitors, PNU‐99963 and PNU‐37883A . British Journal of Pharmacology vol. 139 , ( 1 ) 122 - 128 .

Zuberi Z, Birnbaumer L, Tinker A ( 2008 ) . The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics . AJP Regulatory Integrative and Comparative Physiology vol. 295 , ( 6 ) r1822 - r1830 .

Campanella M, Tan C, Abramov A, Tinker A, Duchen M ( 2008 ) . S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1 . Biochimica et Biophysica Acta (BBA) - Bioenergetics vol. 1777 ,

Quinn KV, Behe P, Tinker A ( 2008 ) . Monitoring changes in membrane phosphatidylinositol 4,5‐bisphosphate in living cells using a domain from the transcription factor tubby . The Journal of Physiology vol. 586 , ( 12 ) 2855 - 2871 .

Breckenridge RA, Zuberi Z, Felkin L, Birks E, Barton P, Tinker A, Mohun T ( 2008 ) . 446 Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice . European Journal of Heart Failure Supplements vol. 7 , 109 - 109 .

Farzaneh T, Tinker A ( 2008 ) . Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits . Cardiovascular Research vol. 79 , ( 4 ) 621 - 631 .

Thomas AM, Tinker A ( 2008 ) . Determination of Phosphoinositide Binding to K+ Channel Subunits Using a Protein—Lipid Overlay Assay . Methods in Molecular Biology vol. 491 , 103 - 111 .

Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR, TINKER A, Duchen MR ( 2008 ) . Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase . Cell Metabolism vol. 8 , ( 1 ) 13 - 25 .

Brown DA, Hughes SA, Marsh SJ, Tinker A ( 2007 ) . Regulation of M(Kv7.2/7.3) channels in neurons by PIP2 and products of PIP2 hydrolysis: significance for receptor‐mediated inhibition . The Journal of Physiology . vol. 582 , 917 - 925 .

Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG, Clapp LH ( 2007 ) . IP receptor-dependent activation of PPARγ by stable prostacyclin analogues . Biochemical and Biophysical Research Communications vol. 360 , ( 4 ) 821 - 827 .

Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K, Tinker A ( 2007 ) . Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies . Clinical Endocrinology vol. 67 , ( 1 ) 115 - 124 .

Hughes S, Marsh SJ, Tinker A, Brown DA ( 2007 ) . PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons . Pflügers Archiv - European Journal of Physiology vol. 455 , ( 1 ) 115 - 124 .

Tennant BP, Cui Y, Tinker A, Clapp LH ( 2007 ) . Functional Expression of Inward Rectifier Potassium Channels in Cultured Human Pulmonary Smooth Muscle Cells: Evidence for a Major Role of Kir2.4 Subunits . The Journal of Membrane Biology vol. 213 , ( 1 ) 19 - 29 .

Harmer SC, Tinker A ( 2007 ) . The role of abnormal trafficking of KCNE1 in long QT syndrome 5 . Biochemical Society Transactions vol. 35 , 1074 - 1076 .

Thomas AM, Brown SG, Leaney JL, Tinker A ( 2006 ) . Differential Phosphoinositide Binding to Components of the G Protein-Gated K+ Channel . The Journal of Membrane Biology vol. 211 , ( 1 ) 43 - 53 .

Kang Y, Ng B, Leung Y-M, He Y, Xie H, Lodwick D, Norman RI, Tinker A et al. ( 2006 ) . Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation* . Journal of Biological Chemistry vol. 281 , ( 28 ) 19019 - 19028 .

Tinker A ( 2006 ) . The selective interactions and functions of regulators of G-protein signalling . Seminars in Cell and Developmental Biology vol. 17 , ( 3 ) 377 - 382 .

Nobles M, Benians A, Tinker A ( 2005 ) . Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells . Proceedings of the National Academy of Sciences of the United States of America vol. 102 , ( 51 ) 18706 - 18711 .

Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M, Tinker A ( 2005 ) . Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1) . Cardiovascular Research vol. 67 , ( 3 ) 476 - 486 .

Brown SG, Thomas A, Dekker LV, Tinker A, Leaney JL ( 2005 ) . PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells . American Journal of Physiology - Cell Physiology vol. 289 , ( 3 ) c543 - c556 .

Benians A, Nobles M, Hosny S, Tinker A ( 2005 ) . Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein A NOVEL EXPLANATION FOR THE ACCELERATION OF SIGNALING ACTIVATION KINETICS* . Journal of Biological Chemistry vol. 280 , ( 14 ) 13383 - 13394 .

Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X et al. ( 2005 ) . Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature . BMC Physiology vol. 5 , ( 1 )

Benians A, Nobles M, Tinker A ( 2004 ) . Participation of RGS8 in the ternary complex of agonist, receptor and G-protein . Biochemical Society Transactions . vol. 32 , 1045 - 1047 .

Leaney JL, Dekker LV, Tinker A ( 2004 ) . Regulation of a G protein‐gated inwardly rectifying K+ channel by a Ca2+‐independent protein kinase C . The Journal of Physiology vol. 534 , ( 2 ) 367 - 379 .

Quinn KV, Giblin JP, Tinker A ( 2004 ) . Multisite Phosphorylation Mechanism for Protein Kinase A Activation of the Smooth Muscle ATP-Sensitive K+ Channel . Circulation Research vol. 94 , ( 10 ) 1359 - 1366 .

Leaney JL, Benians A, Brown S, Nobles M, Kelly D, Tinker A ( 2004 ) . Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle . American Journal of Physiology - Cell Physiology vol. 287 , ( 1 ) c182 - c191 .

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW ( 2004 ) . The large-conductance Ca2+-activated K+ channel is essential for innate immunity . Nature vol. 427 , ( 6977 ) 853 - 858 .

Quinn KV, Cui Y, Giblin JP, Clapp LH, Tinker A ( 2003 ) . Do Anionic Phospholipids Serve as Cofactors or Second Messengers for the Regulation of Activity of Cloned ATP-Sensitive K+ Channels? . Circulation Research vol. 93 , ( 7 ) 646 - 655 .

Benians A, Leaney JL, Tinker A ( 2003 ) . Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels . Proceedings of the National Academy of Sciences of the United States of America vol. 100 , ( 10 ) 6239 - 6244 .

Benians A, Leaney JL, Milligan G, Tinker A ( 2003 ) . The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor* . Journal of Biological Chemistry vol. 278 , ( 12 ) 10851 - 10858 .

Giblin JP, Quinn K, Tinker A ( 2002 ) . The cytoplasmic C‐terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking . The FEBS Journal vol. 269 , ( 21 ) 5303 - 5313 .

Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R et al. ( 2002 ) . KATP Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect . Circulation vol. 106 , ( 12 ) 1556 - 1562 .

Leaney JL, Benians A, Graves FM, Tinker A ( 2002 ) . A Novel Strategy to Engineer Functional Fluorescent Inhibitory G-protein α Subunits* . Journal of Biological Chemistry vol. 277 , ( 32 ) 28803 - 28809 .

Giblin JP, Cui Y, Clapp LH, Tinker A ( 2002 ) . Assembly Limits the Pharmacological Complexity of ATP-sensitive Potassium Channels* . Journal of Biological Chemistry vol. 277 , ( 16 ) 13717 - 13723 .

Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ, Tinker A ( 2002 ) . Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery . American Journal of Respiratory Cell and Molecular Biology vol. 26 , ( 2 ) 194 - 201 .

Cui Y, Tran S, Tinker A, Clapp LH ( 2002 ) . The Molecular Composition of KATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by Growth . American Journal of Respiratory Cell and Molecular Biology vol. 26 , ( 1 ) 135 - 143 .

Huang L, Bitner-Glindzicz M, Tranebjærg L, Tinker A ( 2001 ) . A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome . Cardiovascular Research vol. 51 , ( 4 ) 670 - 680 .

Cui Y, Giblin JP, Clapp LH, Tinker A ( 2001 ) . A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits . Proceedings of the National Academy of Sciences of the United States of America vol. 98 , ( 2 ) 729 - 734 .

Graves FM, Tinker A ( 2000 ) . Functional Expression of the Pore Forming Subunit of the ATP-Sensitive Potassium Channel in Saccharomyces cerevisiae . Biochemical and Biophysical Research Communications vol. 272 , ( 2 ) 403 - 409 .

Leaney JL, Tinker A ( 2000 ) . The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel . Proceedings of the National Academy of Sciences of the United States of America vol. 97 , ( 10 ) 5651 - 5656 .

Leaney JL, Milligan G, Tinker A ( 2000 ) . The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels* . Journal of Biological Chemistry vol. 275 , ( 2 ) 921 - 929 .

Giblin JP, Leaney JL, Tinker A ( 1999 ) . The Molecular Assembly of ATP-sensitive Potassium Channels DETERMINANTS ON THE PORE FORMING SUBUNIT* . Journal of Biological Chemistry vol. 274 , ( 32 ) 22652 - 22659 .

Tinker A, Jan LY ( 1999 ) . Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels . Current Topics in Membranes vol. 46 , 143 - 158 .

Lucie H, Tinker A ( 1998 ) . Potassium channels in the vasculature . Current Opinion in Nephrology & Hypertension vol. 7 , ( 1 ) 83 - 98 .

Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR et al. ( 1997 ) . Structural Components of Ryanodine Responsible for Modulation of Sarcoplasmic Reticulum Calcium Channel Function † . Biochemistry vol. 36 , ( 10 ) 2939 - 2950 .

Tinker A, Jan YN, Jan LY ( 1996 ) . Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels . Cell vol. 87 , ( 5 ) 857 - 868 .

Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR et al. ( 1996 ) . Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel . Biophysical Journal vol. 70 , ( 5 ) 2110 - 2119 .

Tinker A, Williams AJ ( 1995 ) . Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers . Biophysical Journal vol. 68 , ( 1 ) 111 - 120 .

Lindsay AR, Tinker A, Williams AJ ( 1994 ) . How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel? . The Journal of General Physiology vol. 104 , ( 3 ) 425 - 447 .

Tinker A, Williams AJ ( 1993 ) . Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations . The Journal of General Physiology vol. 102 , ( 6 ) 1107 - 1129 .

Tinker A, Lindsay ARG, Williams AJ ( 1993 ) . Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions . Cardiovascular Research vol. 27 , ( 10 ) 1820 - 1825 .

Tinker A, Williams AJ ( 1993 ) . Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel . Biophysical Journal vol. 65 , ( 4 ) 1678 - 1683 .

Tinker A, Williams AJ ( 1993 ) . Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel . Biophysical Journal vol. 65 , ( 2 ) 852 - 864 .

Tinker A, Lindsay AR, Williams AJ ( 1992 ) . A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum . The Journal of General Physiology vol. 100 , ( 3 ) 495 - 517 .

Tinker A, Williams AJ ( 1992 ) . Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum . The Journal of General Physiology vol. 100 , ( 3 ) 479 - 493 .

Tinker A, Lindsay AR, Williams AJ ( 1992 ) . Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel . Biophysical Journal vol. 61 , ( 5 ) 1122 - 1132 .

Tinker A, Lindsay ARG, Williams AJ ( 1992 ) . Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations . The Journal of Membrane Biology vol. 127 , ( 2 ) 149 - 159 .

Tinker A, Lindsay ARG, Williams AJ ( 1992 ) . A model for ionic conduction in the sheep cardiac ryanodine receptor-channel . Journal of Physiology . vol. 446 ,