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Publications:  Prof Andrew Tinker

Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al.(2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications vol. 11, (1)
10.1038/s41467-020-15706-x
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al.(2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Journal of Molecular Medicine
10.1007/s00109-020-01946-3
Villar D, Frost S, Deloukas P, Tinker A(2020). The contribution of non-coding regulatory elements to cardiovascular disease. Open biology vol. 10, (7)
10.1098/rsob.200088
van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD(2020). Genetic Basis and Prognostic Value of Exercise QT Dynamics. Circ Genom Precis Med
10.1161/CIRCGEN.119.002774
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV et al.(2020). Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. Life science alliance vol. 3, (4)
10.26508/lsa.201900593
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A(2020). Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. American Journal of Human Genetics
10.1016/j.ajhg.2020.04.009
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65500
Balestrini S, Mikati M, Garcia-Roves RA, Carboni M, Hunanyan A, Kherallah B, McLean M, Prange L et al. (2019). Cardiac Phenotype In ATP1A3 Related-Syndromes: A Multicentre Study. EPILEPSIA. vol. 60, 173-173.
Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M et al.(2019). Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics. Circulation: Arrhythmia and Electrophysiology vol. 12, (10) e007549-e007549.
10.1161/CIRCEP.119.007549
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61114
Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A, Munroe PB(2019). Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function. Hum Mol Genet
10.1093/hmg/ddz198
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59560
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al.(2019). Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages. Physiol Genomics vol. 51, (8) 323-332.
10.1152/physiolgenomics.00012.2019
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59231
Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA et al.(2019). Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome. Am J Physiol Cell Physiol
10.1152/ajpcell.00028.2019
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58961
Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al. (2019). Identification of novel loci for heart rate response to exercise and recovery. EUROPEAN JOURNAL OF HUMAN GENETICS. vol. 27, 135-135.
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al.(2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Journal of the American College of Cardiology vol. 73, (24) 3118-3131.
10.1016/j.jacc.2019.03.519
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62235
van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe PB, Lambiase P (2019). CARDIAC REPOLARIZATION DURING EXERCISE REVEALS INDEPENDENT PROGNOSTIC INFORMATION FOR CARDIOVASCULAR RISK PREDICTION. HEART. vol. 105, A19-A20.
10.1136/heartjnl-2019-BCS.21
Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A, Schilling RJ(2019). Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method. J Cardiovasc Electrophysiol vol. 30, (5) 691-701.
10.1111/jce.13882
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59229
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al.(2019). Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype. British Journal of Dermatology vol. 180, (5) 1114-1122.
10.1111/bjd.17388
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49603
Ramirez J, van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB (2019). THE CARDIOVASCULAR PREDICTIVE VALUE AND GENETIC BASIS OF T-WAVE MORPHOLOGY. HEART. vol. 105, A18-A19.
10.1136/heartjnl-2019-BCS.20
Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A et al.(2019). Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D. Front Physiol vol. 10, 259-259.
10.3389/fphys.2019.00259
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57721
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. (2019). CRISPR/Cas9 genome editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy. HUMAN GENE THERAPY. vol. 30, A5-A5.
Scott ES, Awford J, Hyde R, Hassan M, Hashmi L, Harmer S, Fischer P, Kellam B et al. (2019). Using bioluminescent hiPSC reporter lines and high content screening to identify novel compounds for cardiomyocyte maturation. HUMAN GENE THERAPY. vol. 30, A8-A8.
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al. (2018). CRISPR/Cas9 gene editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy. HUMAN GENE THERAPY. vol. 29, A93-A94.
Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng KE, Blaydon DC, Tinker A et al.(2018). P63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Nature Communications vol. 9, (1)
10.1038/s41467-018-03470-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36456
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al.(2018). Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system. Nature Communications vol. 9, (1)
10.1038/s41467-018-04148-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39943
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al.(2018). CRISPR/Cas9 editing in human pluripotent stemcell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. European Heart Journal vol. 39, (43) 3879-3892.
10.1093/eurheartj/ehy249
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39283
Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M et al.(2018). Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1). Circ Arrhythm Electrophysiol vol. 11, (10) e006740-e006740.
10.1161/CIRCEP.118.006740
https://qmro.qmul.ac.uk/xmlui/handle/123456789/51363
Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A, Scambler PJ(2018). Defective Vagal Innervation in Murine Tbx1 Mutant Hearts. J Cardiovasc Dev Dis vol. 5, (4)
10.3390/jcdd5040049
https://qmro.qmul.ac.uk/xmlui/handle/123456789/48004
Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA et al.(2018). Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome. Circ Arrhythm Electrophysiol vol. 11, (9) e006330-e006330.
10.1161/CIRCEP.118.006330
https://qmro.qmul.ac.uk/xmlui/handle/123456789/51903
Ramirez J, Van Duijvenboden S, Laguna P, Pueyo E, Tinker A, Lambiase PD, Munroe PB, Orini M (2018). Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology. Computing in Cardiology. Conference: Computing in Cardiology (Maastricht, The Netherlands) from: 23/09/2018 to: 26/09/2018, vol. 2018-September,
10.22489/CinC.2018.039
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59557
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al. (2018). Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker. EUROPEAN HEART JOURNAL. vol. 39, 1206-1206.
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al.(2018). Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology vol. 19, (1)
10.1186/s13059-018-1457-6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/42707
Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A(2018). ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. Journal of Biological Chemistry vol. 293, (23) 8912-8921.
10.1074/jbc.RA118.002775
https://qmro.qmul.ac.uk/xmlui/handle/123456789/45503
Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA et al.(2018). A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism
10.1177/0271678X18780602
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39866
Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A(2018). Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria. Am J Physiol Cell Physiol vol. 314, (5) C616-C626.
10.1152/ajpcell.00271.2016
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32123
Tinker A, Finlay M, Nobles M, Opel A(2018). Erratum to "The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation" [Pharmacol. Res. 105 (2016) 54-61]. Pharmacol Res vol. 129,
10.1016/j.phrs.2018.02.019
Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE et al.(2018). Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology. Circ Genom Precis Med vol. 11, (2) e001813-e001813.
10.1161/CIRCGEN.117.001813
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34943
Orini M, Tinker A, Munroe PB, Lambiase PD(2018). Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. PLoS One vol. 13, (2) e0193039-e0193039.
10.1371/journal.pone.0193039
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56173
Tinker A, Aziz Q, Li Y, Specterman M(2018). ATP-sensitive potassium channels and their physiological and pathophysiological roles. Comprehensive Physiology vol. 8, (4) 1463-1511.
10.1002/cphy.c170048
https://qmro.qmul.ac.uk/xmlui/handle/123456789/45743
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al.(2018). Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Circulation. Genomic and precision medicine vol. 11, (1)
10.1161/CIRCGEN.117.001817
https://qmro.qmul.ac.uk/xmlui/handle/123456789/45703
Aziz Q, Li Y, Tinker A(2018). Potassium channels in the sinoatrial node and their role in heart rate control. Channels vol. 12, (1) 356-366.
10.1080/19336950.2018.1532255
https://qmro.qmul.ac.uk/xmlui/handle/123456789/48005
Aziz Q, Li Y, Tinker A(2017). Endothelial biology and ATP-sensitive potassium channels. Channels1-2.
10.1080/19336950.2017.1412151
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32204
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al.(2017). Ajmaline blocks I<inf>Na</inf> and I<inf>Kr</inf> without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Research vol. 25, 233-244.
10.1016/j.scr.2017.11.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29483
TINKER A, Lane J D(2017). Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?. Frontiers in Physiology vol. 8,
10.3389/fphys.2017.00890
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29044
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV et al.(2017). Mammalian γ2 AMPK regulates intrinsic heart rate. Nat Commun vol. 8, (1) 1258-1258.
10.1038/s41467-017-01342-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28831
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E, Tinker A(2017). Molecular and functional characterization of the endothelial ATP-sensitive potassium channel. Journal of Biological Chemistry vol. 292, (43) 17587-17597.
10.1074/jbc.M117.810325
https://qmro.qmul.ac.uk/xmlui/handle/123456789/45543
Royal AA, Tinker A, Harmer SC(2017). Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. PLoS One vol. 12, (10) Article 0186293, e0186293-e0186293.
10.1371/journal.pone.0186293
https://qmro.qmul.ac.uk/xmlui/handle/123456789/28828
Lane JD, Montaigne D, Tinker A (2017). Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. United States , vol. 250, is. 5, pp. 471-481. Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,
10.1007/s00232-017-9973-y
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25563
Orini M, Tinker A, Munroe PB, Lambiase PD(2017). Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. PLoS One vol. 12, (9) e0183732-e0183732.
10.1371/journal.pone.0183732
https://qmro.qmul.ac.uk/xmlui/handle/123456789/34309
Tinker A(2017). The mechanisms of ventricular arrhythmia in Chagas disease. Int J Cardiol vol. 240, 372-373.
10.1016/j.ijcard.2017.03.094
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59233
Munroe PB, Tinker A(2017). Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart vol. 104, (1) 6-7.
10.1136/heartjnl-2017-311657
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24967
Finlay M, Harmer SC, Tinker A(2017). The control of cardiac ventricular excitability by autonomic pathways. Pharmacology and Therapeutics vol. 174, 97-111.
10.1016/j.pharmthera.2017.02.023
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19577
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al.(2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Molecular and Cellular Endocrinology vol. 447, 12-22.
10.1016/j.mce.2017.02.030
Cartwright J, Aziz Q, Harmer S, Tinker A, Munroe P (2017). Functional Studies of TRPM7-a Candidate Gene for Stillbirth?. FASEB JOURNAL. Conference: EB vol. 31,
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59037
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H, Cabrera CP(2017). Discovery of novel heart rate-associated loci using the exome chip. Human Molecular Genetics
10.1093/hmg/ddx113
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22369
MUNROE PB(2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Genetics
10.1038/ng.3654
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13707
Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A(2016). The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Physiol Rep vol. 4, (15)
10.14814/phy2.12860
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15411
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al.(2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep vol. 16, (4) 1026-1038.
10.1016/j.celrep.2016.06.050
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13911
Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A (2016). Loss of the inhibitory GalphaO protein in the rostral ventrolateral medulla of the brainstem leads to abnormalities in cardiovascular reflexes and altered ventricular excitablitiy. CARDIOVASCULAR RESEARCH. Conference: ESC meeting vol. 111, S98-S98.
Tinker A, Finlay M, Nobles M, Opel A(2016). The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation. Pharmacol Res vol. 105, 54-61.
10.1016/j.phrs.2015.11.008
Harmer SC, Tinker A(2016). The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes. Biol Chem vol. 397, (7) 679-693.
10.1515/hsz-2015-0306
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22079
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB et al.(2016). Human-based approaches to pharmacology and cardiology: An interdisciplinary and intersectorial workshop. Europace vol. 18, (9) 1287-1298.
10.1093/europace/euv320
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A, Baker JR(2016). Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. Organic and Biomolecular Chemistry vol. 14, (2) 455-459.
10.1039/c5ob02120k
Munroe PB, Tinker A(2015). Genome-wide association studies and contribution to cardiovascular physiology. Physiological Genomics vol. 47, (9) 365-375.
10.1152/physiolgenomics.00004.2015
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8221
Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A, Baker JR(2015). A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. Organic and Biomolecular Chemistry vol. 13, (37) 9559-9563.
10.1039/c5ob01468a
Machhada A, Ang R, Ackland G, Ninkina N, Buchman V, Lythgoe MF, Trapp S, Tinker A et al. (2015). Reduced activity of dorsal vagal preganglionic neurones associated with synuclein pathology predisposes the heart to ventricular arrhythmia. EUROPEAN HEART JOURNAL. vol. 36, 215-215.
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R, Tinker A(2015). Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling. J Biol Chem vol. 290, (31) 19233-19244.
10.1074/jbc.M115.666719
Lambiase PD, Tinker A(2015). Connexins in the heart. Cell Tissue Res vol. 360, (3) 675-684.
10.1007/s00441-014-2020-8
Yeoh A, Finlay M, Anderson N, Harmer S, Tinker A (2015). SIMULTANEOUS MEASUREMENT OF CALCIUM TRANSIENTS AND ELECTRICAL ACTIVITY IN MURINE CARDIAC TISSUE - A NOVEL SYSTEM FOR THE STUDY OF CARDIAC ARRHYTHMIA. HEART. vol. 101, A92-A93.
10.1136/heartjnl-2015-308066.162
Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A, Hussain K(2015). Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8. Human Molecular Genetics vol. 24, (18) 5142-5153.
10.1093/hmg/ddv233
Notari M, Hu Y, Sutendra G, Dedei¿ Z, Lu M, Dupays L, Yavari A, Carr CA et al.(2015). iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proceedings of the National Academy of Sciences of the United States of America vol. 112, (9) E973-E981.
10.1073/pnas.1408111112
Aziz Q, Li Y, Tinker A(2015). ATP-sensitive potassium channels and vascular function. Channels vol. 9, (1) 3-4.
10.1080/19336950.2015.1004289
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A et al.(2015). Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Heart Rhythm vol. 12, (11) 2285-2293.
10.1016/j.hrthm.2015.06.005
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13063
Lane JD, Abramowitz J, Birnbaumer L, Tinker A(2014). 51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure. Europace vol. 16 Suppl 3,
10.1093/europace/euu241.1
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L et al.(2014). The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control. Hypertension vol. 64, (3) 523-529.
10.1161/HYPERTENSIONAHA.114.03116
Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD, Tinker A(2014). Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1. Biochem J vol. 462, (1) 133-142.
10.1042/BJ20140425
Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A, Baker JR(2014). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. ORGANIC & BIOMOLECULAR CHEMISTRY vol. 12, (4) 557-560.
10.1039/c3ob42141d
Arya VB, Aziz Q, Nessa A, Tinker A, Hussain K(2014). Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy. Int J Pediatr Endocrinol vol. 2014, (1)
10.1186/1687-9856-2014-24
Tinker A, Aziz Q, Thomas A(2014). The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol vol. 171, (1) 12-23.
10.1111/bph.12407
Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA(2013). Essential Role of the m(2)R-RGS6-I-KACh Pathway in Controlling Intrinsic Heart Rate Variability. PLOS ONE vol. 8, (10) Article ARTN e76973,
10.1371/journal.pone.0076973
Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L, Tinker A(2013). The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins. Am J Physiol Regul Integr Comp Physiol vol. 305, (4) R435-R442.
10.1152/ajpregu.00037.2013
Ang R, Birnbaumer L, Gourine AV, Tinker A (2013). The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart. EUROPEAN HEART JOURNAL. vol. 34, 928-928.
Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA(2013). A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P-2. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY vol. 465, (7) 945-953.
10.1007/s00424-012-1199-3
Ang R, Birnbaumer L, Gourine A, Tinker A (2013). THE ROLE OF INHIBITORY G PROTEIN GALPHAO-MEDIATED SIGNALLING IN THE CENTRAL NERVOUS MECHANISMS CONTROLLING SYMPATHETIC OUTFLOW TO THE HEART. HEART. vol. 99, A121-A121.
10.1136/heartjnl-2013-304019.223
Schwarzer S, Mashanov GI, Molloy JE, Tinker A(2013). Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly. Methods Mol Biol vol. 998, 201-208.
10.1007/978-1-62703-351-0_15
Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C(2012). NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. DEVELOPMENTAL BIOLOGY vol. 369, (2) 277-285.
10.1016/j.ydbio.2012.06.026
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