Publications: Prof Federica Marelli-Berg

Sikking MA, Harding D, Henkens MTHM, Stroeks SLVM, Venner MFGHM, Nihant B, van Leeuwen REW, Fanti S et al. ( 2024 ) . Cytotoxic T-Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy . Circulation Research

Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S et al. ( 2024 ) . Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation . Nature Cardiovascular Research vol. 3 , ( 9 ) 1067 - 1082 .

Aikawa E, Allison MA, Arispe LI, Bendeck MP, Chen Y, Gardiner EE, Golledge J, Suzuki-Inoue K et al. ( 2024 ) . Honoring the Life and Legacy of Dr David A. Dichek . Arteriosclerosis Thrombosis and Vascular Biology vol. 44 , ( 7 ) 1459 - 1461 .

Powell JT, Marelli-Berg FM, Bendeck MP, Schmidt AM ( 2024 ) . Introducing Socrates’ Corner to ATVB Journal: Critical Appraisals of Animal Models of Disease . Arteriosclerosis Thrombosis and Vascular Biology vol. 44 , ( 7 ) 1465 - 1466 .

Martin J, Hollowood Z, Chorlton J, Dyer C, Marelli-Berg F ( 2024 ) . Modulating regulatory T cell migration in the treatment of autoimmunity and autoinflammation . Current Opinion in Pharmacology vol. 77 ,

Golino M, Harding D, Del Buono MG, Fanti S, Mohiddin S, Toldo S, Smyth J, Sanna T et al. ( 2024 ) . Innate and adaptive immunity in acute myocarditis . International Journal of Cardiology vol. 404 ,

Harding D, Fanti S, Marelli-Berg F ( 2023 ) . Tumour necrosis factor-α in cardiac inflammation: friend or foe? . Cardiovascular Research vol. 120 , ( 1 ) 1 - 2 .

Harding D, Marelli-Berg F ( 2023 ) . Interferon-gamma signs off an old heart . Cardiovascular Research vol. 119 , ( 14 ) 2387 - 2389 .

Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al. ( 2023 ) . The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing . Nature Metabolism

Bonacina F, Moregola A, Svecla M, Catapano A, Marelli-Berg F, Norata G ( 2023 ) . The low-density lipoprotein receptor fuels cholesterol-mTORC1 axis during CD8 T cell activation . Atherosclerosis vol. 379 ,

Sikking MA, Stroeks SLVM, Marelli-Berg F, Heymans SRB, Ludewig B, Verdonschot JAJ ( 2023 ) . Immunomodulation of Myocardial Fibrosis . JACC Basic to Translational Science vol. 8 , ( 11 ) 1477 - 1488 .

Rathod KS, Kapil V, Velmurugan S, Khambata RS, Siddique U, Khan S, Van Eijl S, Gee LC et al. ( 2023 ) . Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans . Journal of Clinical Investigation vol. 133 , ( 2 )

Ward EJ, Bert S, Fanti S, Malone KM, Maughan RT, Gkantsinikoudi C, Prin F, Volpato LK et al. ( 2022 ) . Placental Inflammation Leads to Abnormal Embryonic Heart Development . Circulation vol. 147 , ( 12 ) 956 - 972 .

Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al. ( 2022 ) . Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity . Circulation vol. 146 , ( 25 ) 1930 - 1945 .

Allan ME, Fan S, Marelli-Berg FM, Yaqoob MM, Mccafferty K ( 2022 ) . ADOPTION Study Protocol: AZD1656 in Transplantation With Diabetes to Promote Immune Tolerance . Journal of the American Society of Nephrology vol. 33 , ( 11S ) 972 - 972 .

Mohiddin SA, Guttmann O, Marelli‐Berg F ( 2022 ) . Vaccine‐Triggered Acute Autoimmune Myocarditis: Defining, Detecting, and Managing an Apparently Novel Condition . Journal of the American Heart Association vol. 11 , ( 21 )

Bonacina F, Moregola A, Svecla M, Coe D, Uboldi P, Fraire S, Beretta S, Beretta G et al. ( 2022 ) . The low-density lipoprotein receptor–mTORC1 axis coordinates CD8+ T cell activation . Journal of Cell Biology vol. 221 , ( 11 )

Harding D, Chong MHA, Lahoti N, Bigogno CM, Prema R, Mohiddin SA, Marelli‐Berg F ( 2022 ) . Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy . Journal of Internal Medicine vol. 293 , ( 1 ) 23 - 47 .

Chorlton J, Hollowood Z, Dyer C, Lockhart D, Boekman P, McCafferty K, Coffey P, Marelli-Berg F et al. ( 2022 ) . A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial - implications for therapeutic immune modulation . EClinicalMedicine vol. 51 ,

Bonacina F, Moregola A, Coe D, Svecla M, Fraire S, Beretta G, Uboldi P, Catapano AL et al. ( 2022 ) . The low-density lipoprotein receptor fuels the cellular cholesterol-mTORC1 axis required for CD8+ T cell activation . Atherosclerosis vol. 355 , 8 - 9 .

Nath M, Romaine SPR, Koekemoer A, Hamby S, Webb TR, Nelson CP, Castellanos‐Uribe M, Papakonstantinou M et al. ( 2022 ) . Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure . European Journal of Heart Failure vol. 24 , ( 6 ) 1009 - 1019 .

Coe D, Poobalasingam T, Fu H, Bonacina F, Wang G, Morales V, Moregola A, Mitro N et al. ( 2022 ) . Loss of hydrogen voltage-gated channel-1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T-cells . JCI Insight vol. 7 , ( 10 )

Schiattarella GG, Alcaide P, Condorelli G, Gillette TG, Heymans S, Jones EAV, Kallikourdis M, Lichtman A et al. ( 2022 ) . Immunometabolic mechanisms of heart failure with preserved ejection fraction . Nature Cardiovascular Research vol. 1 , ( 3 ) 211 - 222 .

Bonacina F, Moregola A, Coe D, Svecla M, Fraire S, Beretta G, Uboldi P, Catapano AL et al. ( 2022 ) . THE LOW-DENSITY LIPOPROTEIN RECEPTOR FUELS THE CELLULAR CHOLESTEROL-MTORC1 AXIS REQUIRED FOR CD8+T CELL ACTIVATION . ATHEROSCLEROSIS . vol. 355 , E41 - E41 .

Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD et al. ( 2021 ) . Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues . The FASEB Journal vol. 36 , ( 1 )

Marino S ( 2021 ) . Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma . Nature Communications

Jangani M, Vuononvirta J, Yamani L, Ward E, Capasso M, Nadkarni S, Balkwill F, Marelli-Berg F ( 2021 ) . Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators . Journal of Leukocyte Biology vol. 111 , ( 5 ) 967 - 980 .

Trevelin SC, Zampetaki A, Sawyer G, Ivetic A, Brewer AC, Smyth LA, Marelli-Berg F, Köchl R et al. ( 2021 ) . Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency . JCI Insight vol. 6 , ( 18 )

Subramanian M, Marelli-Berg FM ( 2021 ) . CD36 pumps fat to defang killer T cells in tumors . Cell Metabolism vol. 33 , ( 8 ) 1509 - 1511 .

Bonacina F, Moregola A, Coe D, Svecla M, Beretta G, Uboldi P, Pellegatta F, Catapano AL et al. ( 2021 ) . The low-density lipoprotein receptor (LDL-R) is an immune-metabolic checkpoint during CD8 T Lymphocytes activation . Atherosclerosis vol. 331 ,

Bajaj R, Sinclair HC, Patel K, Low B, Pericao A, Manisty C, Guttmann O, Zemrak F et al. ( 2021 ) . Delayed-onset myocarditis following COVID-19 . The Lancet Respiratory Medicine vol. 9 , ( 4 ) e32 - e34 .

Jacob J, Nadkarni S, Volpe A, Peng Q, Tung S, Hannen R, Scotta C, Lechler RI et al. ( 2021 ) . Evaluation of Competing Methodologies for In Vivo Tracking of Human Regulatory T Cells Intended for Adoptive Cell Therapy in Transplantation . MOLECULAR THERAPY . vol. 29 , 384 - 384 .

Jacob J, Nadkarni S, Volpe A, Peng Q, Tung SL, Hannen RF, Mohseni YR, Scotta C et al. ( 2020 ) . Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment . Molecular Therapy — Methods & Clinical Development vol. 20 , 324 - 336 .

Bonacina F, Moregola A, Coe D, Pellegatta F, Catapano AL, Marelli-Berg F, Norata DG ( 2020 ) . The low density lipoprotein receptor (LDLR) is crucial for the activation of CD8+ TCELLS . Atherosclerosis vol. 315 ,

Wood EG, Macdougall CE, Blythe H, Clément M, Colas RA, Dalli J, Marelli-Berg F, Longhi MP ( 2020 ) . HIF1α activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipids . Scientific Reports vol. 10 , ( 1 )

Vuononvirta J, Marelli-Berg FM, Poobalasingam T ( 2020 ) . Metabolic regulation of T lymphocyte motility and migration . Molecular Aspects of Medicine vol. 77 ,

Solito E, Marelli-Berg F, Fanti S, Cheung K, Mauro C, Wang G, Nair A, Fu H et al. ( 2020 ) . Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming . Nature Communications vol. 11 ,

Protonotarios A, Marelli-Berg F ( 2020 ) . Influenza-associated cardiac injury: a disease of the cardiac conduction system? . Cardiovascular Research vol. 117 , ( 3 ) 643 - 644 .

Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M et al. ( 2020 ) . COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options . Cardiovascular Research vol. 116 , ( 10 ) 1666 - 1687 .

Protonotarios A, Marelli-Berg F ( 2020 ) . Towards precision disease-modelling in experimental myocarditis . Cardiovascular Research vol. 116 , ( 10 ) 1656 - 1657 .

Marelli-Berg FM, Aksentijevic D ( 2019 ) . Immunometabolic cross-talk in the inflamed heart . Cell Stress vol. 3 , ( 8 ) 240 - 266 .

Macdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M et al. ( 2019 ) . Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice . Diabetes vol. 68 , ( 7 ) 1473 - 1484 .

Fu H, Jangani M, Parmar A, Wang G, Coe D, Spear S, Sandrock I, Capasso M et al. ( 2019 ) . A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer . Frontiers in Immunology vol. 10 ,

Goldberg R, Scotta C, Cooper D, Nissim-Eliraz E, Nir E, Tasker S, Irving PM, Sanderson J et al. ( 2019 ) . Correction of Defective T-Regulatory Cells From Patients With Crohn’s Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α . Gastroenterology vol. 156 , ( 6 ) 1775 - 1787 .

Nadkarni S, Smith J, Sferruzzi‐Perri A, Kishore M, Mauro C, Williams D, Marelli‐Berg F, Perretti M ( 2017 ) . Neutrophils Induce Pro‐angiogenic T cells with a Regulatory Phenotype in Pregnancy . The FASEB Journal . vol. 31 ,

Stephenson E, Coe D, Nadkarni S, Cheung KCP, Lota AS, Savvatis K, Prasad SK, Mohiddin SA et al. ( 2018 ) . P4527c-Met as a novel T-cell marker in patients with acute myocarditis and dilated cardiomyopathy . European Heart Journal vol. 39 , ( suppl_1 )

Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P et al. ( 2018 ) . Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation . Nature Communications vol. 9 , ( 1 )

Moregola A, Bonacina F, Coe DJ, Mitro N, Catapano AL, Marelli-Berg FM, Norata GD ( 2018 ) . Impact of LDL receptor on lymphocytes T cell differentiation and function . Atherosclerosis . vol. 275 , e21 - e22 .

Cheung KCP, Marelli-Berg FM ( 2018 ) . Isolation of Microvascular Endothelial Cells . Bio-protocol vol. 8 , ( 12 )

Marelli-Berg FM, Nadkarni S ( 2018 ) . Displacing, squeezing, and ramming: The role of nuclear lamins in leukocyte migration . Journal of Leukocyte Biology vol. 104 , ( 2 ) 235 - 236 .

Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A et al. ( 2018 ) . Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis . Immunity vol. 48 , ( 4 ) 831 - 832 .

Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L et al. ( 2018 ) . Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets . Cell Metabolism vol. 27 , ( 3 ) 588 - 601.e4 .

Marelli-Berg FM, Jangani M ( 2018 ) . Metabolic regulation of leukocyte motility and migration . Journal of Leukocyte Biology vol. 104 , ( 2 ) 285 - 293 .

CHEUNG CPK ( 2018 ) . Endothelial Cells: Immunological Aspects . eLS

Macdougall C, Wood E, Charalambous M, Gaston-Massuet C, Taketo MM, Marelli-Berg F, Longhi MP ( 2018 ) . Investigating β-catenin signalling in conventional dendritic cells in obesity-induced tissue inflammation . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 48 , 18 - 19 .

Stephenson E, Coe D, Nadkarni S, Cheung KCP, Lota AS, Savvatis K, Prasad SK, Mohiddin SA et al. ( 2018 ) . c-Met as a novel T-cell marker in patients with acute myocarditis and dilated cardiomyopathy . EUROPEAN HEART JOURNAL . vol. 39 , 921 - 921 .

MARELLI-BERG F ( 2017 ) . Regulatory T cell migration is dependent on glucokinase-mediated glycolysis . Immunity vol. 47 , ( 5 ) 875 - 889 .

Bonacina F, Coe D, Wang G, Baragetti A, Pellegatta F, Grigore L, Catapano AL, Marelli-Berg F et al. ( 2017 ) . Apolipoprotein E orchestrates T Naïve to T Effector memory cell polarization by modulating the crosstalk between systemic and immune cells lipid metabolism . Atherosclerosis . vol. 263 ,

Moregola A, Bonacina F, Coe D, Pellegatta F, Grigore L, Garlaschelli K, Baragetti A, Catapano AL et al. ( 2017 ) . LDLR influence on CD4 T cells differentiation in mice and in familial hypercholesterolemia patients . Atherosclerosis . vol. 263 ,

Goldberg R, Scotta C, Cooper D, Irving P, Sanderson J, Shpigel N, Marelli-Berg F, Lombardi G et al. ( 2017 ) . OC-066 Gut specific regulatory t cells – a new frontier for crohn’s disease therapy . Gut . vol. 66 ,

Ward EJ, Fu H, Marelli-Berg F ( 2017 ) . Monitoring Migration of Activated T Cells to Antigen-Rich Non-lymphoid Tissue . Methods Mol Biol vol. 1591 , 215 - 224 .

Rathod K, Kapil V, Velmurugan S, Khambata R, Siddique U, Khan S, Gee L, Bansal J et al. ( 2017 ) . Sex differences in the inflammatory response and inflammation-induced vascular dysfunction . LANCET . Conference: FASEB vol. 389 , 20 - 20 .

MAURO C, Smith J, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Cermenati G et al. ( 2017 ) . Obesity-induced metabolic stress leads to biased effector memory CD4+ T cell differentiation via PI3K p110δ/Akt-mediated signals . Cell Metabolism

Goldberg R, Scotta C, Cooper D, Eliraz E, Nir E, Irving P, Sanderson J, Shpigel N et al. ( 2017 ) . OP028 Gut specific regulatory T cells – a new frontier for Crohn's disease therapy . Journal of Crohn's and Colitis vol. 11 , ( suppl_1 ) s17 - s17 .

Goldberg R, Scotta C, Cooper D, Eliraz E, Nir E, Irving P, Sanderson J, Shpigel N et al. ( 2017 ) . Gut specific regulatory T cells - a new frontier for Crohn's disease therapy . JOURNAL OF CROHNS & COLITIS . vol. 11 , S17 - S17 .

Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM et al. ( 2016 ) . Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection . Am J Transplant

NADKARNI SA, Smith J, Mauro C, Marelli-Berg FM, Perretti M, Sferruzzi-Perri AN, Ledwozyw A, Kishore M et al. ( 2016 ) . Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy . Proceedings of the National Academy of Sciences of USA

AHLUWALIA A ( 2016 ) . Accelerated resolution underlies sex differences in the inflammatory response in human . Journal of Clinical Investigation vol. 127 , ( 1 ) 169 - 182 .

Stephenson E, Savvatis K, Mohiddin SA, Marelli‐Berg FM ( 2016 ) . T‐cell immunity in myocardial inflammation: pathogenic role and therapeutic manipulation . British Journal of Pharmacology vol. 174 , ( 22 ) 3914 - 3925 .

Fu H, Ward EJ, Marelli-Berg FM ( 2016 ) . Mechanisms of T cell organotropism . Cellular and Molecular Life Sciences vol. 73 , ( 16 ) 3009 - 3033 .

Smith J, Mauro C, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Catapano A et al. ( 2016 ) . Saturated fatty acids-induced metabolic stress leads to biased effector memory CD4<SUP>+</SUP> T cell differentiation via mTOR-independent, PI3K p110d/Akt-mediated signals . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 1046 - 1046 .

Cheung K, Ma L, Wang G, Coe D, Ferro R, Falasca M, Buckley CD, Mauro C et al. ( 2015 ) . CD31 signals confer immune privilege to the vascular endothelium . Proceedings of the National Academy of Sciences of the United States of America vol. 112 , ( 43 ) e5815 - e5824 .

Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O’Neill LAJ, Marelli-Berg FM ( 2015 ) . The Cellular and Molecular Basis of Translational Immunometabolism . Immunity vol. 43 , ( 3 ) 421 - 434 .

Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al. ( 2015 ) . Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions . PLOS Biology vol. 13 , ( 7 )

Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S et al. ( 2015 ) . Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release . Immunity vol. 42 , ( 6 ) 1087 - 1099 .

Mauro C, De Rosa V, Marelli-Berg F, Solito E ( 2015 ) . Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier . Frontiers in Immunology vol. 5 ,

Hondares E, Brown M, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D et al. ( 2015 ) . Enhanced Activation of an Amino-Terminally Truncated Isoform of Voltage-Gated Proton Channel HVCN1 Enriched in Malignant B cells . Biophysical Journal vol. 108 , ( 2 )

Hondares E, Brown M, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D et al. ( 2015 ) . Enhanced activation of an amino-terminally truncated isoform of voltage-gated proton channel HVCN1 enriched in malignant B cells . ACTA PHYSIOLOGICA vol. 213 , 39 - 39 .

Hondares E, Brown MA, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D et al. ( 2014 ) . Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 111 , ( 50 ) 18078 - 18083 .

Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ et al. ( 2014 ) . Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation . Nature Communications vol. 5 , ( 1 )

Haas R, Smith J, Rocher-Ros V, Montero-Melendez T, D'Acquisto F, Bland EJ, Bombardieri M, Pitzalis C et al. ( 2014 ) . How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions . IMMUNOLOGY vol. 143 , 151 - 151 .

Coe DJ, Kishore M, Marelli-Berg F ( 2014 ) . Metabolic regulation of regulatory T cell development and function . Frontiers in immunology vol. 5 ,

Nicolaou A, Mauro C, Urquhart P, Marelli-Berg F ( 2014 ) . Polyunsaturated Fatty Acid-derived lipid mediators and T cell function . Front Immunol vol. 5 ,

Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ et al. ( 2014 ) . Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation . IMMUNOLOGY vol. 143 , 124 - 124 .

Vianello F, Cannella L, Coe D, Chai J, Golshayan D, Marelli‐Berg FM, Dazzi F ( 2013 ) . Enhanced and aberrant T cell trafficking following total body irradiation: a gateway to graft‐versus‐host disease? . British Journal of Haematology vol. 162 , ( 6 ) 808 - 818 .

Haas R, Marelli-Berg FM, Mauro C ( 2013 ) . In the eye of the storm: T cell behavior in the inflammatory microenvironment . American Journal of Clinical and Experimental Immunology vol. 2 , ( 2 ) 146 - 155 .

Marelli-Berg FM, Clement M, Mauro C, Caligiuri G ( 2013 ) . An immunologist's guide to CD31 function in T-cells . Journal of Cell Science vol. 126 , ( 11 ) 2343 - 2352 .

Cheung K, Mauro C, Marelli-Berg FM ( 2013 ) . Molecular mechanisms of endothelial cytoprotection by CD31-mediated signals . IMMUNOLOGY . vol. 140 , 65 - 65 .

Haas R, Smith J, Marelli-Berg F, Nicolaou A, Mauro C ( 2013 ) . Omega-3 fatty acids inhibit the migration of T lymphocytes . IMMUNOLOGY . vol. 140 , 34 - 34 .

Fu H, Wang A, Mauro C, Marelli-Berg FM ( 2013 ) . T lymphocyte trafficking: molecules and mechanisms . Front Biosci vol. 18 , ( 2 ) 422 - 440 .

Smith J, Coe D, Fu H, Okkenhaug K, Marelli-Berg F, Mauro C ( 2013 ) . The effect of obesity-induced metabolic stress on T cell migration . IMMUNOLOGY . vol. 140 , 97 - 97 .

Fu H, Ying H, Rose ML, McCormack AM, Sarathchandra P, Okkenhaug K, MarelliBerg F ( 2012 ) . Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase p110δ Prevents Chronic Rejection of Heart Allografts . Transplantation . vol. 94 ,

Kishore M, Ma L, Cornish G, Nourshargh S, MarelliBerg F ( 2012 ) . Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31 . Transplantation . vol. 94 ,

Ma L, Cheung KCP, Kishore M, Nourshargh S, Mauro C, Marelli-Berg FM ( 2012 ) . CD31 Exhibits Multiple Roles in Regulating T Lymphocyte Trafficking In Vivo . The Journal of Immunology vol. 189 , ( 8 ) 4104 - 4111 .

Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al. ( 2012 ) . S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells . Clinical & Experimental Metastasis vol. 30 , ( 3 ) 251 - 264 .

Mauro C, Fu H, Marelli-Berg FM ( 2012 ) . T cell trafficking and metabolism: novel mechanisms and targets for immunomodulation . Curr Opin Pharmacol vol. 12 , ( 4 ) 452 - 457 .

Marelli‐Berg FM, Fu H, Mauro C ( 2012 ) . Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T‐cell‐mediated immunity . Immunology vol. 136 , ( 4 ) 363 - 369 .

Kishore M, Ma L, Cornish G, Nourshargh S, Marelli-Berg FM ( 2012 ) . Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31 . PLOS ONE vol. 7 , ( 6 )

Ying H, Fu H, Rose ML, McCormack AM, Sarathchandra P, Okkenhaug K, Marelli-Berg FM ( 2012 ) . Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase P110δ Prevents Chronic Rejection of Heart Allografts . PLOS ONE vol. 7 , ( 3 )

Mirenda V, Marelli-Berg FM ( 2012 ) . Understanding Cell Migration Through the Paradigm of T-Lymphocyte Homing . Stem Cell Repair and Regeneration , World Scientific Publishing

Ma L, Cheung KC, Kishore M, Nourshargh S, Mauro C, Marelli-Berg FM ( 2012 ) . CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo . J Immunol vol. 189 , ( 8 ) 4104 - 4111 .

Mauro C, Marelli-Berg FM ( 2012 ) . T Cell Immunity and Cardiovascular Metabolic Disorders: Does Metabolism Fuel Inflammation? . Frontiers in Immunology vol. 3 ,

Harris SJ, Parry RV, Foster JG, Blunt MD, Wang A, Marelli-Berg F, Westwick J, Ward SG ( 2011 ) . Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility . J Immunol vol. 186 , ( 8 ) 4936 - 4945 .

Ma L, Mauro C, Cornish GH, Chai J-G, Coe D, Fu H, Patton D, Okkenhaug K et al. ( 2010 ) . Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance . Proceedings of the National Academy of Sciences of the United States of America vol. 107 , ( 45 ) 19461 - 19466 .

Cernuda-Morollón E, Millán J, Shipman M, Marelli-Berg FM, Ridley AJ ( 2010 ) . Rac Activation by the T-Cell Receptor Inhibits T Cell Migration . PLOS ONE vol. 5 , ( 8 )

Marelli‐Berg FM, Fu H, Vianello F, Tokoyoda K, Hamann A ( 2010 ) . Memory T‐cell trafficking: new directions for busy commuters . Immunology vol. 130 , ( 2 ) 158 - 165 .

Zhu D, Jarmin S, Ribeiro A, Prin F, Xie SQ, Sullivan K, Briscoe J, Gould AP et al. ( 2010 ) . Applying an Adaptive Watershed to the Tissue Cell Quantification During T-Cell Migration and Embryonic Development . T-Cell Trafficking , vol. 616 , Springer Nature

Gorman CL, Monaco C, Ammiratti E, Vermi A-C, Marelli-Berg FM, Cope AP ( 2010 ) . Tracking Antigen-Experienced Effector T Cells In Vitro and In Vivo . T-Cell Trafficking , vol. 616 , Springer Nature

Ma L, Mauro C, Cornish G, Chai JG, Coe D, Fu H, Patton D, Okkenhaug K et al. ( 2010 ) . Ig gene-like molecule CD31 plays a non-redundant role in the regulation of T cell immunity and tolerance . Proc Natl Acad Sci U S A. vol. 107 , ( 45 ) 19461 - 19466 .

Ward SG, Marelli-Berg FM ( 2009 ) . Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation . Biochemical Journal vol. 418 , ( 1 ) 13 - 27 .

David R, Ma L, Ivetic A, Takesono A, Ridley AJ, Chai JG, Tybulewicz VL, Marelli-Berg FM ( 2009 ) . T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue . Blood vol. 113 , ( 16 ) 3696 - 3705 .

Wang A, Dinesen L, Dazzi T, Marelli-Berg F, Ghosh S ( 2008 ) . Prospective study of lymphocyte trafficking to the intestine, changes in lymphocyte sub-populations in peripheral blood and modification by anti-inflammatory therapy . IMMUNOLOGY . vol. 125 , 105 - 105 .

Lechler R, Marelli‐Berg FM ( 2008 ) . Mechanisms of peripheral T‐cell tolerance . Journal of Viral Hepatitis vol. 4 , ( s2 ) 1 - 5 .

Dazzi F, Marelli‐Berg FM ( 2008 ) . Mesenchymal stem cells for graft‐versus‐host disease: Close encounters with T cells . European Journal of Immunology vol. 38 , ( 6 ) 1479 - 1482 .

Jarmin SJ, David R, Ma L, Chai JG, Dewchand H, Takesono A, Ridley AJ, Okkenhaug K et al. ( 2008 ) . T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice . J Clin Invest vol. 118 , ( 3 ) 1154 - 1164 .

Marelli-Berg FM, Cannella L, Dazzi F, Mirenda V ( 2008 ) . The highway code of T cell trafficking . JOURNAL OF PATHOLOGY vol. 214 , ( 2 ) 179 - 189 .

Zhang Z, Gorman CL, Vermi A-C, Monaco C, Foey A, Owen S, Amjadi P, Vallance A et al. ( 2007 ) . TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues . Blood vol. 109 , ( 10 ) 4328 - 4335 .

Marelli-Berg FM, Okkenhaug K, Mirenda V ( 2007 ) . A two-signal model for T cell trafficking . Trends in Immunology vol. 28 , ( 6 ) 267 - 273 .

FOSTER GR, Avraamides G, Ng CY, Lombardi G, Marelli-Berg FM, Runkel L, Gu Y, Mirenda V et al. ( 2007 ) . IFN-alpha2 induces leukocyte integrin redistribution, increased adhesion, and migration . J Interferon Cytokine Res vol. 27 , 291 - 303 .

David R, Takesono A, Ridley A, Tybulewicz V, Marelli-Berg F ( 2007 ) . Loss of Vav1 results in defective retention of T cells into antigenic sites . IMMUNOLOGY . vol. 120 , 65 - 65 .

Gorman CL, Zhang Z, Vermi AC, Monaco C, Marelli-Berg F, Dazzi F, Cope AP ( 2007 ) . TCR-zeta dim T cells define a population of circulating effector cells that migrate to inflamed tissues . ANNALS OF THE RHEUMATIC DISEASES . vol. 66 , A17 - A17 .

Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K et al. ( 2007 ) . Physiological and aberrant regulation of memory T cell trafficking by the co-stimulatory molecule CD28 . IMMUNOLOGY . vol. 120 , 31 - 31 .

David R, Marelli-Berg FM ( 2007 ) . Regulation of T-cell migration by co-stimulatory molecules . BIOCHEMICAL SOCIETY TRANSACTIONS . vol. 35 , 1114 - 1118 .

Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K et al. ( 2006 ) . Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28 . Blood vol. 109 , ( 7 ) 2968 - 2977 .

Gordon MY, Levicar N, Pai M, Bachellier P, Dimarakis I, Al-Allaf F, M'Hamdi H, Thalji T et al. ( 2006 ) . Characterization and clinical application of human CD34(+) stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor . STEM CELLS vol. 24 , ( 7 ) 1822 - 1830 .

Marelli‐Berg FM, Nourshargh S ( 2006 ) . Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules . Leukocyte Trafficking , Wiley

Murelii‐Berg FM, Lechler RI ( 2006 ) . Antigen presentation by parenchymal cells: a route to peripheral tolerance? . Immunological Reviews vol. 172 , ( 1 ) 297 - 314 .

Garden OA, Reynolds PR, Yates J, Larkman DJ, Marelli-Berg FM, Haskard DO, Edwards AD, George AJT ( 2006 ) . A rapid method for labelling CD4<SUP>+</SUP> T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour <i>in vitro</i> . JOURNAL OF IMMUNOLOGICAL METHODS vol. 314 , ( 1-2 ) 123 - 133 .

Datta A, David R, Glennie S, Scott D, Cernuda-Morollon E, Lechler RI, Ridley AJ, Marelli-Berg FM ( 2006 ) . Differential effects of immunosuppressive drugs on T-cell motility . AMERICAN JOURNAL OF TRANSPLANTATION vol. 6 , ( 12 ) 2871 - 2883 .

Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Rudd CE, Tybulewicz VL, Lechler RI et al. ( 2005 ) . CD28 engagement promotes T cell migration and antigen-independent T cell: dendritic cell interactions . IMMUNOLOGY vol. 116 , 7 - 7 .

Mirenda V, Millington O, Lechler RI, Scott D, Read J, Tan PH, George AJ, Garside P et al. ( 2005 ) . Tolerant T cells display impaired trafficking ability . IMMUNOLOGY vol. 116 , 44 - 44 .

Mirenda V, Millington O, Lechler RI, Scott D, Hernandez‐Fuentes MP, Read J, Tan PH, George AJT et al. ( 2005 ) . Tolerant T cells display impaired trafficking ability . European Journal of Immunology vol. 35 , ( 7 ) 2146 - 2156 .

Cannella L, Laylor R, Marelli-Berg F, Dazzi F ( 2005 ) . Irradiation influences endothelial cell function in vitro and in vivo: a possible role of IP10 . BONE MARROW TRANSPLANTATION . vol. 35 , S342 - S342 .

Nourshargh S, Marelli-Berg FM ( 2005 ) . Transmigration through venular walls: a key regulator of leukocyte phenotype and function . Trends in Immunology vol. 26 , ( 3 ) 157 - 165 .

Cannella L, Laylor R, Marelli-Berg F, Dazzi F ( 2005 ) . Irradiation influences endothelial cell function in vitro and in vivo: A possible role for IP10 . BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION . vol. 11 , 45 - 45 .

Elliott JI, Surprenant A, Marelli-Berg FM, Cooper JC, Cassady-Cain RL, Wooding C, Linton KJ, Alexander DR et al. ( 2005 ) . Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes . Nat. Cell Biol. vol. 7 , 808 - 816 .

Herrera OB, Golshayan D, Tibbott R, Ochoa FS, James MJ, Marelli-Berg FM, Lechler RI ( 2004 ) . A Novel Pathway of Alloantigen Presentation by Dendritic Cells . The Journal of Immunology vol. 173 , ( 8 ) 4828 - 4837 .

FOSTER GR, Lombardi G, Jones M, David R, Sizing I, Runkell L, Marelli-Berg FM, Masri S et al. ( 2004 ) . IFN-alpha subtypes differentially affect human T cell motility . J Immunology vol. 173 , 1663 - 1670 .

Foster GR, Masri SH, David R, Jones M, Datta A, Lombardi G, Runkell L, De Dios C et al. ( 2004 ) . IFN-α subtypes differentially affect human T cell motility . Journal of Immunology vol. 173 , ( 3 ) 1663 - 1670 .

Chandrasekar B, Marelli-Berg FM, Tone M, Bysani S, Prabhu SD, Murray DR ( 2004 ) . β-Adrenergic stimulation induces interleukin-18 expression via β2-AR, PI3K, Akt, IKK, and NF-κB . Biochemical and Biophysical Research Communications vol. 319 , ( 2 ) 304 - 311 .

Marelli-Berg FM, Jarmin SJ ( 2004 ) . Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking? . Immunology Letters vol. 93 , ( 2-3 ) 109 - 113 .

Cannella L, Laylor R, Dewchand H, Simpson E, Marelli-Berg F, Dazzi F ( 2004 ) . The conditioning regimen influences migration of donor T-cells in recipient tissues . BONE MARROW TRANSPLANTATION . vol. 33 , S176 - S176 .

Marelli-Berg FM, James MJ, Dangerfield J, Dyson J, Millrain M, Scott D, Simpson E, Nourshargh S et al. ( 2003 ) . Cognate recognition of the endothelium induces HY-specific CD8+T-lymphocyte transendothelial migration (diapedesis) in vivo . Blood vol. 103 , ( 8 ) 3111 - 3116 .

James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D et al. ( 2003 ) . Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism . Blood vol. 102 , ( 6 ) 2173 - 2179 .

Dong R, Cwynarski K, Entwistle A, Marelli-Berg F, Dazzi F, Simpson E, Goldman JM, Melo JV et al. ( 2003 ) . Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration . Blood vol. 101 , ( 9 ) 3560 - 3567 .

Chandrasekar B, Melby PC, Sarau HM, Raveendran M, Perla RP, Marelli-Berg FM, Dulin NO, Singh IS ( 2002 ) . Chemokine-Cytokine Cross-talk THE ELR+ CXC CHEMOKINE LIX (CXCL5) AMPLIFIES A PROINFLAMMATORY CYTOKINE RESPONSE VIA A PHOSPHATIDYLINOSITOL 3-KINASE-NF-κB PATHWAY* . Journal of Biological Chemistry vol. 278 , ( 7 ) 4675 - 4686 .

Berg L-P, James MJ, Alvarez-Iglesias M, Glennie S, Lechler RI, Marelli-Berg FM ( 2002 ) . Functional Consequences of Noncognate Interactions Between CD4+ Memory T Lymphocytes and the Endothelium . The Journal of Immunology vol. 168 , ( 7 ) 3227 - 3234 .

Lidington EA, Rao RM, Marelli-Berg FM, Jat PS, Haskard DO, Mason JC ( 2002 ) . Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2Kb-tsA58 mice . American Journal of Physiology - Cell Physiology vol. 282 , ( 1 ) c67 - c74 .

Lechler R, Chai JG, Marelli-Berg F, Lombardi G ( 2001 ) . The contributions of T-cell anergy to peripheral T-cell tolerance . Immunology vol. 103 , ( 3 ) 262 - 269 .

Lechler R, Chai J-G, Marelli-Berg F, Lombard G ( 2001 ) . Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance . Philosophical Transactions of the Royal Society B Biological Sciences vol. 356 , ( 1409 ) 659 - 663 .

Lechler R, Chai JG, Marelli-Berg F, Lombardi G ( 2001 ) . T-cell anergy and peripheral T-cell tolerance . Philos Trans R Soc Lond B Biol Sci vol. 356 , ( 1409 ) 625 - 637 .

Lidington EA, Rao RM, Marelli-Berg F, Jat P, Haskard DO, Mason JC ( 2001 ) . Isolation and characterisation of conditionally immortal growth factor responsive cardiac endothelial cells (EC) from H-2K(b)-tsA58 transgenic mice . RHEUMATOLOGY vol. 40 , 8 - 8 .

Marelli-Berg FM, Scott D, Bartok I, Peek E, Dyson J, Lechler RI ( 2001 ) . Antigen presentation by murine endothelial cells . Transplantation Proceedings vol. 33 , ( 1-2 ) 315 - 316 .

Marelli-Berg FM, Alvarez-Iglesias M, Prodromidou K, Lombardi G, Frasca L, Berg L-P, Lechler RI ( 2001 ) . T cell receptor engagement can influence T cell motility . Transplantation Proceedings vol. 33 , ( 1-2 ) 312 - 313 .

Lidington EA, Rao RM, Marelli-Berg F, Jat P, Haskard DO, Mason JC ( 2000 ) . Establishment and characterisation of a conditionally transformed immortalised murine cardiac endothelial cell line isolated from H2kb-tsA58 transgenic mice . CIRCULATION vol. 102 , ( 18 ) 329 - 329 .

Marelli-Berg FM, Scott D, Bartok I, Peek E, Dyson J, Lechler RI ( 2000 ) . Activated Murine Endothelial Cells Have Reduced Immunogenicity for CD8+ T Cells: A Mechanism of Immunoregulation? . The Journal of Immunology vol. 165 , ( 8 ) 4182 - 4189 .

Marelli-Berg FM, Peek E, Lidington EA, Stauss HJ, Lechler RI ( 2000 ) . Isolation of endothelial cells from murine tissue . Journal of Immunological Methods vol. 244 , ( 1-2 ) 205 - 215 .

Marelli-Berg FM, Frasca L, Imami N, Lombardi G, Lechler RI ( 1999 ) . LACK OF T CELL PROLIFERATION WITHOUT INDUCTION OF NONRESPONSIVENESS AFTER ANTIGEN PRESENTATION BY ENDOTHELIAL CELLS1 . Transplantation vol. 68 , ( 2 ) 280 - 287 .

Marelli-Berg FM, Barroso-Herrera O, Lechler RI ( 1999 ) . Recently Activated T Cells Are Costimulation-Dependent in Vitro . Cellular Immunology vol. 195 , ( 1 ) 18 - 27 .

Marelli-Berg FM, Frasca L, Weng L, Lombardi G, Lechler RI ( 1999 ) . Antigen recognition influences transendothelial migration of CD4+ T cells . The Journal of Immunology vol. 162 , ( 2 ) 696 - 703 .

Frasca L, Amendola A, Hornick P, Brookes P, Aichinger G, Marelli-Berg F, Lechler RI, Lombardi G ( 1998 ) . Role of donor and recipient antigen-presenting cells in priming and maintaining T cells with indirect allospecificity . Transplantation vol. 66 , ( 9 ) 1238 - 1243 .

Metcalfe RA, McIntosh RS, Marelli-Berg F, Lombardi G, Lechler R, Weetman AP ( 1998 ) . Detection of CD40 on human thyroid follicular cells: analysis of expression and function . J Clin Endocrinol Metab vol. 83 , ( 4 ) 1268 - 1274 .

Frasca L, Marelli-Berg F, Imami N, Potolicchio I, Carmichael P, Lombardi G, Lechler R ( 1998 ) . Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance . Kidney Int vol. 53 , ( 3 ) 679 - 689 .

Marelli-Berg FM, Weetman A, Frasca L, Deacock SJ, Imami N, Lombardi G, Lechler RI ( 1997 ) . Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells . The Journal of Immunology vol. 159 , ( 12 ) 5853 - 5861 .

Lechler RI, Marelli-Berg FM ( 1997 ) . Do endothelial cells fit the paradigm of antigen-presenting cells? . Biochemical Society Transactions vol. 25 , ( 2 ) 723 - 727 .

Lombardi G, Arnold K, Uren J, Marelli-Berg F, Hargreaves R, Imami N, Weetman A, Lechler R ( 1997 ) . Antigen presentation by interferon-gamma-treated thyroid follicular cells inhibits interleukin-2 (IL-2) and supports IL-4 production by B7-dependent human T cells . Eur J Immunol vol. 27 , ( 1 ) 62 - 71 .

Marelli-Berg FM, Hargreaves RE, Carmichael P, Dorling A, Lombardi G, Lechler RI ( 1996 ) . Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells . Journal of Experimental Medicine vol. 183 , ( 4 ) 1603 - 1612 .