Publications:  Prof Federica Marelli-Berg

Protonotarios A, Marelli-Berg F(2020). Towards precision disease-modelling in experimental myocarditis. Cardiovasc Res

Macdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M et al.(2019). Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice. Diabetes vol. 68, (7) 1473-1484.

Marelli-Berg FM, Aksentijevic D(2019). Immunometabolic cross-talk in the inflamed heart. Cell Stress vol. 3, (8) 240-266.

Goldberg R, Scotta C, Cooper D, Nissim-Eliraz E, Nir E, Tasker S, Irving PM, Sanderson J et al.(2019). Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α. Gastroenterology vol. 156, (6) 1775-1787.

Fu H, Jangani M, Parmar A, Wang G, Coe D, Spear S, Sandrock I, Capasso M et al.(2019). A subset of CCL25-Induced gut-homing T-cells affects intestial immunity to infection and cancer. Frontiers in Immunology vol. 10, (FEB)

Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P et al.(2018). Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation. Nature Communications vol. 9, (1)

Marelli-Berg FM, Jangani M(2018). Metabolic regulation of leukocyte motility and migration. J Leukoc Biol vol. 104, (2) 285-293.

Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A et al.(2018). Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity vol. 48, (4) 831-832.

Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L et al.(2018). Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metabolism vol. 27, (3) 588-601.e4.

MARELLI-BERG F(2017). Regulatory T cell migration is dependent on glucokinase-mediated glycolysis. Immunity vol. 47, (5) 875-889.

Bonacina F, Coe D, Wang G, Baragetti A, Pellegatta F, Grigore L, Catapano AL, Marelli-Berg F et al. (2017). Apolipoprotein E orchestrates T Naïve to T Effector memory cell polarization by modulating the crosstalk between systemic and immune cells lipid metabolism. Atherosclerosis. vol. 263,

Moregola A, Bonacina F, Coe D, Pellegatta F, Grigore L, Garlaschelli K, Baragetti A, Catapano AL et al. (2017). LDLR influence on CD4 T cells differentiation in mice and in familial hypercholesterolemia patients. Atherosclerosis. vol. 263,

Nadkarni S, Smith J, Sferruzzi-Perri A, Kishore M, Mauro C, Williams D, Marelli-Berg F, Perretti M (2017). Neutrophils Induce Pro-angiogenic T cells with a Regulatory Phenotype in Pregnancy. FASEB JOURNAL. vol. 31,

Ward EJ, Fu H, Marelli-Berg F(2017). Monitoring Migration of Activated T Cells to Antigen-Rich Non-lymphoid Tissue. Methods Mol Biol vol. 1591, 215-224.

Rathod K, Kapil V, Velmurugan S, Khambata R, Siddique U, Khan S, Gee L, Bansal J et al. (2017). Sex differences in the inflammatory response and inflammation-induced vascular dysfunction. LANCET. Conference: FASEB vol. 389, 20-20.

MAURO C, Smith J, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Cermenati G et al.(2017). Obesity-induced metabolic stress leads to biased effector memory CD4+ T cell differentiation via PI3K p110δ/Akt-mediated signals. Cell Metabolism

Goldberg R, Scotta C, Cooper D, Eliraz E, Nir E, Irving P, Sanderson J, Shpigel N et al. (2017). Gut specific regulatory T cells - a new frontier for Crohn's disease therapy. JOURNAL OF CROHNS & COLITIS. vol. 11, S17-S17.

Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM et al.(2016). Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection. Am J Transplant

NADKARNI SA, Smith J, Mauro C, Marelli-Berg FM, Perretti M, Sferruzzi-Perri AN, Ledwozyw A, Kishore M et al.(2016). Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy. Proceedings of the National Academy of Sciences of USA

AHLUWALIA A(2016). Accelerated resolution underlies sex differences in the inflammatory response in human. Journal of Clinical Investigation vol. 127, (1) 169-182.

Fu H, Ward EJ, Marelli-Berg FM(2016). Mechanisms of T cell organotropism. Cellular and Molecular Life Sciences vol. 73, (16) 3009-3033.

Smith J, Mauro C, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Catapano A et al. (2016). Saturated fatty acids-induced metabolic stress leads to biased effector memory CD4(+) T cell differentiation via mTOR-independent, PI3K p110d/Akt-mediated signals. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 46, 1046-1046.

Cheung K, Ma L, Wang G, Coe D, Ferro R, Falasca M, Buckley CD, Mauro C et al.(2015). CD31 signals confer immune privilege to the vascular endothelium. Proceedings of the National Academy of Sciences of the United States of America vol. 112, (43) E5815-E5824.

Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O'Neill LAJ, Marelli-Berg FM(2015). The Cellular and Molecular Basis of Translational Immunometabolism. Immunity vol. 43, (3) 421-434.

Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S et al.(2015). Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release. Immunity vol. 42, (6) 1087-1099.

Hondares E, Brown M, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D et al.(2015). Enhanced activation of an amino-terminally truncated isoform of voltage-gated proton channel HVCN1 enriched in malignant B cells. ACTA PHYSIOLOGICA vol. 213, 39-39.

Hondares E, Brown M, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D et al.(2015). Enhanced Activation of an Amino-Terminally Truncated Isoform of Voltage-Gated Proton Channel HVCN1 Enriched in Malignant B cells. BIOPHYSICAL JOURNAL vol. 108, (2) 20A-20A.

Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D¿Acquisto F, Bland EJ, Bombardieri M et al.(2015). Lactate regulates metabolic and proinflammatory circuits in control of T cell migration and effector functions. PLoS Biology vol. 13, (7)

Hondares E, Brown MA, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D et al.(2014). Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 111, (50) 18078-18083.

Haas R, Smith J, Rocher-Ros V, Montero-Melendez T, D'Acquisto F, Bland EJ, Bombardieri M, Pitzalis C et al.(2014). How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions. IMMUNOLOGY vol. 143, 151-151.

Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ et al.(2014). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. IMMUNOLOGY vol. 143, 124-124.

Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ et al.(2014). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nature Communications vol. 5,

Coe DJ, Kishore M, Marelli-Berg F(2014). Metabolic regulation of regulatory T cell development and function. Frontiers in immunology vol. 5,

Mauro C, De Rosa V, Marelli-Berg F, Solito E(2014). Metabolic syndrome and the immunological affair with the blood-brain barrier. Front Immunol vol. 5,

Nicolaou A, Mauro C, Urquhart P, Marelli-Berg F(2014). Polyunsaturated Fatty Acid-derived lipid mediators and T cell function. Front Immunol vol. 5,

Cheung K, Mauro C, Marelli-Berg FM (2013). Molecular mechanisms of endothelial cytoprotection by CD31-mediated signals. IMMUNOLOGY. vol. 140, 65-65.

Haas R, Smith J, Marelli-Berg F, Nicolaou A, Mauro C (2013). Omega-3 fatty acids inhibit the migration of T lymphocytes. IMMUNOLOGY. vol. 140, 34-34.

Smith J, Coe D, Fu H, Okkenhaug K, Marelli-Berg F, Mauro C (2013). The effect of obesity-induced metabolic stress on T cell migration. IMMUNOLOGY. vol. 140, 97-97.

Haas R, Marelli-Berg FM, Mauro C(2013). In the eye of the storm: T cell behavior in the inflammatory microenvironment. American Journal of Clinical and Experimental Immunology vol. 2, (2) 146-155.

Marelli-Berg FM, Clement M, Mauro C, Caligiuri G(2013). An immunologist's guide to CD31 function in T-cells. J Cell Sci vol. 126, (Pt 11) 2343-2352.

Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al.(2013). S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. Clinical and Experimental Metastasis vol. 30, (3) 251-264.

Fu H, Wang A, Mauro C, Marelli-Berg FM(2013). T lymphocyte trafficking: molecules and mechanisms. Front Biosci vol. 18, (2) 422-440.

Fu H, Ying H, Rose ML, McCormack AM, Sarathchandra P, Okkenhaug K, Marelli-Berg F (2012). Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase p110 delta Prevents Chronic Rejection of Heart Allografts. TRANSPLANTATION. vol. 94, 443-443.

Kishore M, Ma L, Cornish G, Nourshargh S, Marelli-Berg F (2012). Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31. TRANSPLANTATION. vol. 94, 456-456.

Ma L, Cheung KCP, Kishore M, Nourshargh S, Mauro C, Marelli-Berg FM(2012). CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo. Journal of Immunology vol. 189, (8) 4104-4111.

Marelli-Berg FM, Fu H, Mauro C(2012). Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T-cell-mediated immunity. Immunology vol. 136, (4) 363-369.

Mauro C, Fu H, Marelli-Berg FM(2012). T cell trafficking and metabolism: novel mechanisms and targets for immunomodulation. Curr Opin Pharmacol vol. 12, (4) 452-457.

Kishore M, Ma L, Cornish G, Nourshargh S, Marelli-Berg FM(2012). Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31. PLoS ONE vol. 7, (6)

Ma L, Cheung KC, Kishore M, Nourshargh S, Mauro C, Marelli-Berg FM(2012). CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo. J Immunol vol. 189, (8) 4104-4111.

Mauro C, Marelli-Berg FM(2012). T cell immunity and cardiovascular metabolic disorders: does metabolism fuel inflammation?. Front Immunol vol. 3,

Harris SJ, Parry RV, Foster JG, Blunt MD, Wang A, Marelli-Berg F, Westwick J, Ward SG(2011). Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility. J Immunol vol. 186, (8) 4936-4945.

Ma L, Mauro C, Cornish GH, Chai J-G, Coe D, Fu H, Patton D, Okkenhaug K et al.(2010). Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A vol. 107, (45) 19461-19466.

Ma L, Mauro C, Cornish G, Chai JG, Coe D, Fu H, Patton D, Okkenhaug K et al.(2010). Ig gene-like molecule CD31 plays a non-redundant role in the regulation of T cell immunity and tolerance. Proc Natl Acad Sci U S A. vol. 107, (45) 19461-19466.

David R, Ma L, Ivetic A, Takesono A, Ridley AJ, Chai JG, Tybulewicz VL, Marelli-Berg FM(2009). T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue. Blood vol. 113, (16) 3696-3705.

Wang A, Dinesen L, Dazzi T, Marelli-Berg F, Ghosh S (2008). Prospective study of lymphocyte trafficking to the intestine, changes in lymphocyte sub-populations in peripheral blood and modification by anti-inflammatory therapy. IMMUNOLOGY. vol. 125, 105-105.

Jarmin SJ, David R, Ma L, Chai JG, Dewchand H, Takesono A, Ridley AJ, Okkenhaug K et al.(2008). T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice. J Clin Invest vol. 118, (3) 1154-1164.

Marelli-Berg FM, Cannella L, Dazzi F, Mirenda V(2008). The highway code of T cell trafficking. JOURNAL OF PATHOLOGY vol. 214, (2) 179-189.

David R, Marelli-Berg FM (2007). Regulation of T-cell migration by co-stimulatory molecules. BIOCHEMICAL SOCIETY TRANSACTIONS. vol. 35, 1114-1118.

Zhang Z, Gorman CL, Vermi A-C, Monaco C, Foey A, Owen S, Amjadi P, Vallance A et al.(2007). TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues. Blood vol. 109, (10) 4328-4335.

FOSTER GR, Avraamides G, Ng CY, Lombardi G, Marelli-Berg FM, Runkel L, Gu Y, Mirenda V et al.(2007). IFN-alpha2 induces leukocyte integrin redistribution, increased adhesion, and migration. J Interferon Cytokine Res vol. 27, 291-303.

David R, Takesono A, Ridley A, Tybulewicz V, Marelli-Berg F (2007). Loss of Vav1 results in defective retention of T cells into antigenic sites. IMMUNOLOGY. vol. 120, 65-65.

Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K et al. (2007). Physiological and aberrant regulation of memory T cell trafficking by the co-stimulatory molecule CD28. IMMUNOLOGY. vol. 120, 31-31.

Gorman CL, Zhang Z, Vermi AC, Monaco C, Marelli-Berg F, Dazzi F, Cope AP (2007). TCR-zeta dim T cells define a population of circulating effector cells that migrate to inflamed tissues. ANNALS OF THE RHEUMATIC DISEASES. vol. 66, A17-A17.

Datta A, David R, Glennie S, Scott D, Cernuda-Morollon E, Lechler RI, Ridley AJ, Marelli-Berg FM(2006). Differential effects of immunosuppressive drugs on T-cell motility. AMERICAN JOURNAL OF TRANSPLANTATION vol. 6, (12) 2871-2883.

Garden OA, Reynolds PR, Yates J, Larkman DJ, Marelli-Berg FM, Haskard DO, Edwards AD, George AJT(2006). A rapid method for labelling CD4(+) T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro. JOURNAL OF IMMUNOLOGICAL METHODS vol. 314, (1-2) 123-133.

Gordon MY, Levicar N, Pai M, Bachellier P, Dimarakis I, Al-Allaf F, M'Hamdi H, Thalji T et al.(2006). Characterization and clinical application of human CD34(+) stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. STEM CELLS vol. 24, (7) 1822-1830.

Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Rudd CE, Tybulewicz VL, Lechler RI et al.(2005). CD28 engagement promotes T cell migration and antigen-independent T cell: dendritic cell interactions. IMMUNOLOGY vol. 116, 7-7.

Mirenda V, Millington O, Lechler RI, Scott D, Read J, Tan PH, George AJ, Garside P et al.(2005). Tolerant T cells display impaired trafficking ability. IMMUNOLOGY vol. 116, 44-44.

Cannella L, Laylor R, Marelli-Berg F, Dazzi F (2005). Irradiation influences endothelial cell function in vitro and in vivo: a possible role of IP10. BONE MARROW TRANSPLANTATION. vol. 35, S342-S342.

Nourshargh S, Marelli-Berg FM(2005). Transmigration through venular walls: a key regulator of leukocyte phenotype and function. Trends Immunol vol. 26, (3) 157-165.

Cannella L, Laylor R, Marelli-Berg F, Dazzi F (2005). Irradiation influences endothelial cell function in vitro and in vivo: A possible role for IP10. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. vol. 11, 45-45.

Elliott JI, Surprenant A, Marelli-Berg FM, Cooper JC, Cassady-Cain RL, Wooding C, Linton KJ, Alexander DR et al.(2005). Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes. Nat. Cell Biol. vol. 7, 808-816.

FOSTER GR, Lombardi G, Jones M, David R, Sizing I, Runkell L, Marelli-Berg FM, Masri S et al.(2004). IFN-alpha subtypes differentially affect human T cell motility. J Immunology vol. 173, 1663-1670.

Foster GR, Masri SH, David R, Jones M, Datta A, Lombardi G, Runkell L, De Dios C et al.(2004). IFN-α subtypes differentially affect human T cell motility. Journal of Immunology vol. 173, (3) 1663-1670.

Marelli-Berg FM, James MJ, Dangerfield J, Dyson J, Millrain M, Scott D, Simpson E, Nourshargh S et al.(2004). Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo. Blood vol. 103, (8) 3111-3116.

Cannella L, Laylor R, Dewchand H, Simpson E, Marelli-Berg F, Dazzi F (2004). The conditioning regimen influences migration of donor T-cells in recipient tissues. BONE MARROW TRANSPLANTATION. vol. 33, S176-S176.

James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D et al.(2003). Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. Blood vol. 102, (6) 2173-2179.

Dong R, Cwynarski K, Entwistle A, Marelli-Berg F, Dazzi F, Simpson E, Goldman JM, Melo JV et al.(2003). Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration. Blood vol. 101, (9) 3560-3567.

Chandrasekar B, Melby PC, Sarau HM, Raveendran M, Perla RP, Marelli-Berg FM, Dulin NO, Singh IS(2003). Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem vol. 278, (7) 4675-4686.

Lechler R, Chai JG, Marelli-Berg F, Lombardi G(2001). The contributions of T-cell anergy to peripheral T-cell tolerance. Immunology vol. 103, (3) 262-269.

Lechler R, Chai JG, Marelli-Berg F, Lombardi G(2001). T-cell anergy and peripheral T-cell tolerance. Philos Trans R Soc Lond B Biol Sci vol. 356, (1409) 625-637.

Lidington EA, Rao RM, Marelli-Berg F, Jat P, Haskard DO, Mason JC(2001). Isolation and characterisation of conditionally immortal growth factor responsive cardiac endothelial cells (EC) from H-2K(b)-tsA58 transgenic mice. RHEUMATOLOGY vol. 40, 8-8.

Lidington EA, Rao RM, Marelli-Berg F, Jat P, Haskard DO, Mason JC(2000). Establishment and characterisation of a conditionally transformed immortalised murine cardiac endothelial cell line isolated from H2kb-tsA58 transgenic mice. CIRCULATION vol. 102, (18) 329-329.

Frasca L, Amendola A, Hornick P, Brookes P, Aichinger G, Marelli-Berg F, Lechler RI, Lombardi G(1998). Role of donor and recipient antigen-presenting cells in priming and maintaining T cells with indirect allospecificity. Transplantation vol. 66, (9) 1238-1243.

Metcalfe RA, McIntosh RS, Marelli-Berg F, Lombardi G, Lechler R, Weetman AP(1998). Detection of CD40 on human thyroid follicular cells: analysis of expression and function. J Clin Endocrinol Metab vol. 83, (4) 1268-1274.

Frasca L, Marelli-Berg F, Imami N, Potolicchio I, Carmichael P, Lombardi G, Lechler R(1998). Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance. Kidney Int vol. 53, (3) 679-689.

Lombardi G, Arnold K, Uren J, Marelli-Berg F, Hargreaves R, Imami N, Weetman A, Lechler R(1997). Antigen presentation by interferon-gamma-treated thyroid follicular cells inhibits interleukin-2 (IL-2) and supports IL-4 production by B7-dependent human T cells. Eur J Immunol vol. 27, (1) 62-71.