Publications:  Prof Tyson Sharp

Hall R, O'Loughlin J, Bhaker S, Portelli MA, Henry A, Pang V, Bates DO, Sharp T et al. (2020). Extended Lifespan Bronchial Epithelial Cells Maintain Cellular Phenotype and Transcriptome Integrity. a2298-a2298.

Hewitson JP, Shah KM, Brown N, Grevitt P, Hain S, Newling K, Sharp TV, Kaye PM et al.(2019). miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity. EMBO Rep vol. 20, (4)

O¿Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al.(2019). Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer vol. 26, (1) 165-180.

Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al.(2018). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Mol Med

Chakraborty C, Mitra S, Roychowdhury A, Samadder S, Dutta S, Roy A, Das P, Mandal RK et al.(2018). Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer. Biochem J vol. 475, (10) 1793-1806.

Wang L, Howell MEA, McPeak B, Riggs K, Kohne C, Yohanon JU, Foxler DE, Sharp TV et al.(2018). LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death. Oncotarget vol. 9, (5) 6282-6297.

Yee D, Shah KM, Coles MC, Sharp TV, Lagos D(2017). MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells. J Biol Chem vol. 292, (50) 20683-20693.

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al.(2017). Ajmaline blocks I<inf>Na</inf> and I<inf>Kr</inf> without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Research vol. 25, 233-244.

Sur S, Maurya AK, Roy A, Sharp TV, Pal DK, Panda CK(2017). Over expression of HIF1α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: Clinical importance. Pathology Research and Practice vol. 213, (12) 1477-1481.

Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA (2017). Abstract A31: Targeting APC loss using synthetic lethality in Colorectal Cancer. a31-a31.

Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA (2017). Targeting APC loss using synthetic lethality in Colorectal Cancer. MOLECULAR CANCER THERAPEUTICS. vol. 16,

Bridge KS, Shah KM, Li Y, Foxler DE, Wong SCK, Miller DC, Davidson KM, Foster JG et al.(2017). Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins. Cell Reports vol. 20, (1) 173-187.

Munye MM, Shoemark A, Hirst RA, Delhove JM, Sharp TV, McKay TR, O'Callaghan C, Baines DL et al.(2017). BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity. Am J Physiol Lung Cell Mol Physiol vol. 312, (2) L258-L267.

Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV et al.(2016). Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition. Oncogene

Torr E, Heath M, Mee M, Shaw D, Sharp TV, Sayers I(2016). Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells. Physiological Reports vol. 4, (16)

Warner MJ, Bridge KS, Hewitson JP, Hodgkinson MR, Heyam A, Massa BC, Haslam JC, Chatzifrangkeskou M et al.(2016). S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells. Nucleic Acids Researchgkw631-gkw631.

Smith K, Sheaff M, Elia G, Clear A, Trevisan G, Foxler D, Bridge K, Shepherd S et al.(2016). 888 Loss of LIM-domain proteins LIMD1, Ajuba and WTIP as a novel molecular mechanism for disease aetiology in clear cell renal cell carcinoma (ccRCC). European Journal of Cancer vol. 61,

Feber A, Worth DC, Chakravarthy A, de Winter P, Shah K, Arya M, Saqib M, Nigam R et al.(2016). CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Cancer Research vol. 76, (16) 4720-4727.

Leonov G, Shah K, Yee D, Timmis J, Sharp TV, Lagos D(2015). Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells. Int J Biochem Cell Biol vol. 69, 75-84.

Smith K, Sharp TV, Khetrapal P, Trevisian G (2014). LIMD1 deregulation as a novel molecular mechanism for disease aetiology in clear cell Renal Cell Carcinoma (ccRCC). VIRCHOWS ARCHIV. vol. 465, S7-S7.

Foster JG, Wong SCK, Sharp TV(2014). The hypoxic tumor microenvironment: Driving the tumorigenesis of non-small-cell lung cancer. Future Oncology vol. 10, (16) 2659-2674.

Hawkins KE, Sharp TV, McKay TR(2013). The role of hypoxia in stem cell potency and differentiation. Regen Med vol. 8, (6) 771-782.

King MV, Kurian N, Qin S, Papadopoulou N, Westerink BHC, Cremers TI, Epping-Jordan MP, Le Poul E et al.(2013). Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition. Neuropsychopharmacology vol. 39, (2) 464-476.

Sarkar S, Maiti GP, Jha J, Biswas J, Roy A, Roychoudhury S, Sharp T, Panda CK(2013). Reduction of proliferation and induction of apoptosis are associated with shrinkage of head and neck squamous cell carcinoma due to neoadjuvant chemotherapy. Asian Pacific Journal of Cancer Prevention vol. 14, (11) 6419-6425.

Miliara S, Gkouskou KK, Sharp TV, Eliopoulos AG(2013). SUMOylation is required for optimal TRAF3 signaling capacity. PLoS One vol. 8, (11)

Bridge KS, Sharp TV(2012). Regulators of the hypoxic response: a growing family. FUTURE ONCOLOGY vol. 8, (5) 491-493.

Wong S, Longmore G, Sharp T(2012). LIMD1 (LIM domains containing 1). Atlas of Genetics and Cytogenetics in Oncology and Haematology (10)

James V, Wong SCK, Sharp TV(2012). MicroRNA-mediated gene silencing: are we close to a unifying model?. Biomol Concepts vol. 3, (1) 29-40.

Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SCK, Feng Y, Constantin-Teodosiu D et al.(2012). The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol vol. 14, (2) 201-208.

Maiti GP, Ghosh A, Chatterjee R, Roy A, Sharp TV, Roychoudhury S, Panda CK(2012). Reduced expression of LIMD1 in ulcerative oral epithelium associated with tobacco and areca nut. Asian Pac J Cancer Prev vol. 13, (9) 4341-4346.

González-Estévez C, Felix DA, Smith MD, Paps J, Morley SJ, James V, Sharp TV, Aboobaker AA(2012). SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genet vol. 8, (3)

McKay TR, Camarasa MV, Iskender B, Ye J, Bates N, Miller D, Fitzsimmons JC, Foxler D et al.(2011). Human feeder cell line for derivation and culture of hESc/hiPSc. Stem Cell Res vol. 7, (2) 154-162.

Foxler DE, James V, Shelton SJ, Vallim TQDA, Shaw PE, Sharp TV(2011). PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Lett vol. 585, (7) 1089-1096.

Rothwell DG, Crossley R, Bridgeman JS, Sheard V, Zhang Y, Sharp TV, Hawkins RE, Gilham DE et al.(2010). Functional expression of secreted proteins from a bicistronic retroviral cassette based on foot-and-mouth disease virus 2A can be position dependent. Hum Gene Ther vol. 21, (11) 1631-1637.

King MV, Kurian N, Smith M, Ray D, Fone KCF, Kendall DA, Marsden CA, Sharp TV (2010). REVERSAL OF VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1) LENTIVIRAL SHORT HAIRPIN RNA (SHRNA) VECTOR-INDUCED COGNITIVE DEFICITS BY A 5-HT6 RECEPTOR ANTAGONIST. JOURNAL OF PSYCHOPHARMACOLOGY. vol. 24, A68-A68.

James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y et al.(2010). LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A vol. 107, (28) 12499-12504.

Tsai Y-H, Wu M-F, Wu Y-H, Chang S-J, Lin S-F, Sharp TV, Wang H-W(2009). The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion. J Virol vol. 83, (2) 622-632.

Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM et al.(2008). The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development. Proc Natl Acad Sci U S A vol. 105, (50) 19932-19937.

Spendlove I, Al-Attar A, Watherstone O, Webb TM, Ellis IO, Longmore GD, Sharp TV(2008). Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival. Int J Cancer vol. 123, (10) 2247-2253.

Mckay TR, Sharp TV, Grady L, Camarasa M, Aplin J, Brison D, Kimber S (2008). Genetically modified human placental fibroblasts as feeder cells for human embryonic stem cell derivation and culture. HUMAN GENE THERAPY. vol. 19, 421-421.

Sharp TV, Munoz F, Bourboulia D, Presneau N, Darai E, Wang H-W, Cannon M, Butcher DN et al.(2004). LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. Proc Natl Acad Sci U S A vol. 101, (47) 16531-16536.

Leonard P, Sharp T, Henderson S, Hewitt D, Pringle J, Sandison A, Goodship A, Whelan J et al.(2003). Gene expression array profile of human osteosarcoma. Br J Cancer vol. 89, (12) 2284-2288.

Wang H-W, Sharp TV, Koumi A, Koentges G, Boshoff C(2002). Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin. EMBO J vol. 21, (11) 2602-2615.

Sharp TV, Wang H-W, Koumi A, Hollyman D, Endo Y, Ye H, Du M-Q, Boshoff C(2002). K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. J Virol vol. 76, (2) 802-816.

Sharp TV, Boshoff C(2000). Kaposi's sarcoma-associated herpesvirus: from cell biology to pathogenesis. IUBMB Life vol. 49, (2) 97-104.

Sharp TV, Raine DA, Gewert DR, Joshi B, Jagus R, Clemens MJ(1999). Activation of the interferon-inducible (2'-5') oligoadenylate synthetase by the Epstein-Barr virus RNA, EBER-1. Virology vol. 257, (2) 303-313.

Sharp TV, Moonan F, Romashko A, Joshi B, Barber GN, Jagus R(1998). The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation. Virology vol. 250, (2) 302-315.

Sharp TV, Witzel JE, Jagus R(1997). Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR). Eur J Biochem vol. 250, (1) 85-91.

Sharp TV, Xiao Q, Justesen J, Gewert DR, Clemens MJ(1995). Regulation of the interferon-inducible protein kinase PKR and (2'-5')oligo(adenylate) synthetase by a catalytically inactive PKR mutant through competition for double-stranded RNA binding. Eur J Biochem vol. 230, (1) 97-103.

Xiao Q, Sharp TV, Jeffrey IW, James MC, Pruijn GJ, van Venrooij WJ, Clemens MJ(1994). The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA. Nucleic Acids Res vol. 22, (13) 2512-2518.

Clemens MJ, Laing KG, Jeffrey IW, Schofield A, Sharp TV, Elia A, Matys V, James MC et al.(1994). Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs. Biochimie vol. 76, (8) 770-778.

Sharp TV, Schwemmle M, Jeffrey I, Laing K, Mellor H, Proud CG, Hilse K, Clemens MJ(1993). Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA. Nucleic Acids Res vol. 21, (19) 4483-4490.

Sharp TV, Xiao Q, Jeffrey I, Gewert DR, Clemens MJ(1993). Reversal of the double-stranded-RNA-induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR. Eur J Biochem vol. 214, (3) 945-948.