Publications: Prof Tyson Sharp
Gauthier V, Tyler E, Liu Y, Sharp TV, Pearce OM
(
2023
)
.
Abstract 1339: Targeting specific extracellular matrix proteins to reactivate T cell trafficking in triple-negative breast cancer
.
Cancer Research
vol.
83
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(
7_Supplement
)
1339
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1339
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Davidson K, Grevitt P, Contreras-Gerenas MF, Bridge KS, Hermida M, Shah KM, Mardakheh FK, Stubbs M et al.
(
2021
)
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Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
.
Cell Death & Disease
vol.
12
,
(
11
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O'Loughlin J, Hall RJ, Bhaker S, Portelli MA, Henry A, Pang V, Bates DO, Sharp TV et al.
(
2021
)
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Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity
.
ERJ Open Research
vol.
7
,
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1
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00254
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02020
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Hall R, O'Loughlin J, Bhaker S, Portelli MA, Henry A, Pang V, Bates DO, Sharp T et al.
(
2020
)
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Extended Lifespan Bronchial Epithelial Cells Maintain Cellular Phenotype and Transcriptome Integrity
.
Conference:
A65. EPITHELIAL CELL BIOLOGY: THE PLOT THICKENSa2298
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a2298
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Hewitson JP, Shah KM, Brown N, Grevitt P, Hain S, Newling K, Sharp TV, Kaye PM et al.
(
2019
)
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miR‐132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity
.
EMBO Reports
vol.
20
,
(
4
)
CHAPPLE JP, O'TOOLE S, WATSON D, NOVOSELOVA T, ROMANO L, KING PJ, BRADSHAW T, THOMPSON CL et al.
(
2019
)
.
Oncometabolite induced primary cilia loss in pheochromocytoma
.
Endocrine-Related Cancer
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A et al.
(
2018
)
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A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia
.
EMBO Mol Med
Chakraborty C, Mitra S, Roychowdhury A, Samadder S, Dutta S, Roy A, Das P, Mandal RK et al.
(
2018
)
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Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer
.
Biochemical Journal
vol.
475
,
(
10
)
1793
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1806
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Wang L, Howell MEA, McPeak B, Riggs K, Kohne C, Yohanon JU, Foxler DE, Sharp TV et al.
(
2017
)
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LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death
.
Oncotarget
vol.
9
,
(
5
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6282
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6297
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Yee D, Shah KM, Coles MC, Sharp TV, Lagos D
(
2017
)
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MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells
.
J Biol Chem
vol.
292
,
(
50
)
20683
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20693
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Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al.
(
2017
)
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Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters
.
Stem Cell Research
vol.
25
,
233
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244
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Sur S, Maurya AK, Roy A, Sharp TV, Pal DK, Panda CK
(
2017
)
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Over expression of HIF1α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: Clinical importance
.
Pathology - Research and Practice
vol.
213
,
(
12
)
1477
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1481
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Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA
(
2017
)
.
Abstract A31: Targeting APC loss using synthetic lethality in Colorectal Cancer
.
Molecular Cancer Therapeutics
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vol.
16
,
a31
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a31
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Bridge KS, Shah KM, Li Y, Foxler DE, Wong SCK, Miller DC, Davidson KM, Foster JG et al.
(
2017
)
.
Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins
.
Cell Reports
vol.
20
,
(
1
)
173
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187
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Shailes H, Bridge G, Foxler D, Sharp TV, Silver A, Martin SA
(
2017
)
.
Targeting APC loss using synthetic lethality in Colorectal Cancer
.
MOLECULAR CANCER THERAPEUTICS
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vol.
16
,
Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV et al.
(
2016
)
.
Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition
.
Oncogene
Munye MM, Shoemark A, Hirst RA, Delhove JM, Sharp TV, McKay TR, O'Callaghan C, Baines DL et al.
(
2016
)
.
BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity
.
American Journal of Physiology - Lung Cellular and Molecular Physiology
vol.
312
,
(
2
)
l258
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l267
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Torr E, Heath M, Mee M, Shaw D, Sharp TV, Sayers I
(
2016
)
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Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells
.
Physiological Reports
vol.
4
,
(
16
)
Warner MJ, Bridge KS, Hewitson JP, Hodgkinson MR, Heyam A, Massa BC, Haslam JC, Chatzifrangkeskou M et al.
(
2016
)
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S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells
.
Nucleic Acids Researchgkw631
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gkw631
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Smith K, Sheaff M, Elia G, Clear A, Trevisan G, Foxler D, Bridge K, Shepherd S et al.
(
2016
)
.
888 Loss of LIM-domain proteins LIMD1, Ajuba and WTIP as a novel molecular mechanism for disease aetiology in clear cell renal cell carcinoma (ccRCC)
.
European Journal of Cancer
vol.
61
,
Feber A, Worth DC, Chakravarthy A, de Winter P, Shah K, Arya M, Saqib M, Nigam R et al.
(
2016
)
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CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
.
Cancer Research
vol.
76
,
(
16
)
4720
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4727
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Smith K, Sheaff M, Elia G, Clear A, Trevisan G, Foxler D, Bridge K, Shepherd S et al.
(
2016
)
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Loss of LIM-domain proteins LIMD1, Ajuba and WTIP as a novel molecular mechanism for disease aetiology in clear cell renal cell carcinoma (ccRCC)
.
EUROPEAN JOURNAL OF CANCER
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vol.
61
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S206
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S206
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Leonov G, Shah K, Yee D, Timmis J, Sharp TV, Lagos D
(
2015
)
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Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells
.
The International Journal of Biochemistry & Cell Biology
vol.
69
,
75
-
84
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Foster JG, Wong SC, Sharp TV
(
2014
)
.
The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer
.
Future Oncology
vol.
10
,
(
16
)
2659
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2674
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Smith K, Sharp TV, Khetrapal P, Trevisian G
(
2014
)
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LIMD1 deregulation as a novel molecular mechanism for disease aetiology in clear cell Renal Cell Carcinoma (ccRCC)
.
VIRCHOWS ARCHIV
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vol.
465
,
S7
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S7
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Sarkar S, Maiti GP, Jha J, Biswas J, Roy A, Roychoudhury S, Sharp T, Panda CK
(
2013
)
.
Reduction of Proliferation and Induction of Apoptosis are Associated with Shrinkage of Head and Neck Squamous Cell Carcinoma due to Neoadjuvant Chemotherapy
.
Asian Pacific Journal of Cancer Prevention
vol.
14
,
(
11
)
6419
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6425
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Hawkins KE, Sharp TV, McKay TR
(
2013
)
.
The role of hypoxia in stem cell potency and differentiation
.
Regen Med
vol.
8
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(
6
)
771
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782
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King MV, Kurian N, Qin S, Papadopoulou N, Westerink BHC, Cremers TI, Epping-Jordan MP, Le Poul E et al.
(
2013
)
.
Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition
.
Neuropsychopharmacology
vol.
39
,
(
2
)
464
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476
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Miliara S, Gkouskou KK, Sharp TV, Eliopoulos AG
(
2013
)
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SUMOylation is required for optimal TRAF3 signaling capacity
.
PLoS One
vol.
8
,
(
11
)
Wong S, Longmore G, Sharp T
(
2012
)
.
LIMD1 (LIM domains containing 1)
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Atlas of Genetics and Cytogenetics in Oncology and Haematology
(
10
)
Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SCK, Feng Y, Constantin-Teodosiu D et al.
(
2012
)
.
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
.
Nat Cell Biol
vol.
14
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2
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201
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208
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Maiti GP, Ghosh A, Chatterjee R, Roy A, Sharp TV, Roychoudhury S, Panda CK
(
2012
)
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Reduced expression of LIMD1 in ulcerative oral epithelium associated with tobacco and areca nut
.
Asian Pac J Cancer Prev
vol.
13
,
(
9
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4341
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4346
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Bridge KS, Sharp TV
(
2012
)
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Regulators of the hypoxic response: a growing family
.
FUTURE ONCOLOGY
vol.
8
,
(
5
)
491
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493
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González-Estévez C, Felix DA, Smith MD, Paps J, Morley SJ, James V, Sharp TV, Aboobaker AA
(
2012
)
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SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians
.
PLoS Genet
vol.
8
,
(
3
)
James V, Wong SCK, Sharp TV
(
2011
)
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MicroRNA-mediated gene silencing: are we close to a unifying model?
.
BioMolecular Concepts
vol.
3
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1
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29
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40
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McKay TR, Camarasa MV, Iskender B, Ye J, Bates N, Miller D, Fitzsimmons JC, Foxler D et al.
(
2011
)
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Human feeder cell line for derivation and culture of hESc/hiPSc
.
Stem Cell Res
vol.
7
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2
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154
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162
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Foxler DE, James V, Shelton SJ, Vallim TQDA, Shaw PE, Sharp TV
(
2011
)
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PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1
.
FEBS Lett
vol.
585
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7
)
1089
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1096
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Rothwell DG, Crossley R, Bridgeman JS, Sheard V, Zhang Y, Sharp TV, Hawkins RE, Gilham DE et al.
(
2010
)
.
Functional expression of secreted proteins from a bicistronic retroviral cassette based on foot-and-mouth disease virus 2A can be position dependent
.
Hum Gene Ther
vol.
21
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(
11
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1631
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1637
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James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y et al.
(
2010
)
.
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
.
Proc Natl Acad Sci U S A
vol.
107
,
(
28
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12499
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12504
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King MV, Kurian N, Smith M, Ray D, Fone KCF, Kendall DA, Marsden CA, Sharp TV
(
2010
)
.
REVERSAL OF VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1) LENTIVIRAL SHORT HAIRPIN RNA (SHRNA) VECTOR-INDUCED COGNITIVE DEFICITS BY A 5-HT6 RECEPTOR ANTAGONIST
.
JOURNAL OF PSYCHOPHARMACOLOGY
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vol.
24
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A68
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A68
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Tsai Y-H, Wu M-F, Wu Y-H, Chang S-J, Lin S-F, Sharp TV, Wang H-W
(
2009
)
.
The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion
.
J Virol
vol.
83
,
(
2
)
622
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632
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Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM et al.
(
2008
)
.
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development
.
Proc Natl Acad Sci U S A
vol.
105
,
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50
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19932
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19937
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Spendlove I, Al-Attar A, Watherstone O, Webb TM, Ellis IO, Longmore GD, Sharp TV
(
2008
)
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Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival
.
Int J Cancer
vol.
123
,
(
10
)
2247
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2253
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Mckay TR, Sharp TV, Grady L, Camarasa M, Aplin J, Brison D, Kimber S
(
2008
)
.
Genetically modified human placental fibroblasts as feeder cells for human embryonic stem cell derivation and culture
.
HUMAN GENE THERAPY
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vol.
19
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421
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421
.
Sharp TV, Munoz F, Bourboulia D, Presneau N, Darai E, Wang H-W, Cannon M, Butcher DN et al.
(
2004
)
.
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
.
Proc Natl Acad Sci U S A
vol.
101
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(
47
)
16531
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16536
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Allers KA, Sharp T
(
2004
)
.
GABA neurones in the dorsal raphe nucleus - Where are they, what do they look like, and how are they regulated?
.
NEUROPSYCHOPHARMACOLOGY
.
vol.
29
,
S38
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S38
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Leonard P, Sharp T, Henderson S, Hewitt D, Pringle J, Sandison A, Goodship A, Whelan J et al.
(
2003
)
.
Gene expression array profile of human osteosarcoma
.
British Journal of Cancer
vol.
89
,
(
12
)
2284
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2288
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Wang H-W, Sharp TV, Koumi A, Koentges G, Boshoff C
(
2002
)
.
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin
.
EMBO J
vol.
21
,
(
11
)
2602
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2615
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Sharp TV, Wang H-W, Koumi A, Hollyman D, Endo Y, Ye H, Du M-Q, Boshoff C
(
2002
)
.
K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function
.
J Virol
vol.
76
,
(
2
)
802
-
816
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Sharp TV, Boshoff C
(
2000
)
.
Kaposi's sarcoma-associated herpesvirus: from cell biology to pathogenesis
.
IUBMB Life
vol.
49
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(
2
)
97
-
104
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Sharp TV, Raine DA, Gewert DR, Joshi B, Jagus R, Clemens MJ
(
1999
)
.
Activation of the interferon-inducible (2'-5') oligoadenylate synthetase by the Epstein-Barr virus RNA, EBER-1
.
Virology
vol.
257
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(
2
)
303
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313
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Sharp TV, Moonan F, Romashko A, Joshi B, Barber GN, Jagus R
(
1998
)
.
The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation
.
Virology
vol.
250
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2
)
302
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315
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Sharp TV, Witzel JE, Jagus R
(
1997
)
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Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR)
.
Eur J Biochem
vol.
250
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1
)
85
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91
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Sharp TV, Xiao Q, Justesen J, Gewert DR, Clemens MJ
(
1995
)
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Regulation of the interferon-inducible protein kinase PKR and (2'-5')oligo(adenylate) synthetase by a catalytically inactive PKR mutant through competition for double-stranded RNA binding
.
Eur J Biochem
vol.
230
,
(
1
)
97
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103
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Sharp TV, Xiao Q, Justesen J, Gewert DR, Clemens MJ
(
1995
)
.
Regulation of the Interferon-indueible Protein Kinase PKR and (2'-5')oligo(Adenylate) Synthetase by a Catalytically Inactive PKR Mutant Through Competition for Double-stranded RNA Binding
.
The FEBS Journal
vol.
230
,
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1
)
97
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103
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Xiao Q, Sharp TV, Jeffrey IW, James MC, Pruijn GJ, van Venrooij WJ, Clemens MJ
(
1994
)
.
The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA
.
Nucleic Acids Res
vol.
22
,
(
13
)
2512
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2518
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Clemens MJ, Laing KG, Jeffrey IW, Schofield A, Sharp TV, Elia A, Matys V, James MC et al.
(
1994
)
.
Regulation of the interferon-inducible eIF-2 alpha protein kinase by small RNAs
.
Biochimie
vol.
76
,
(
8
)
770
-
778
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Sharp TV, Schwemmle M, Jeffrey I, Laing K, Mellor H, Proud CG, Hilse K, Clemens MJ
(
1993
)
.
Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA
.
Nucleic Acids Res
vol.
21
,
(
19
)
4483
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4490
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Sharp TV, Xiao Q, Jeffrey I, Gewert DR, Clemens MJ
(
1993
)
.
Reversal of the double-stranded-RNA-induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR
.
Eur J Biochem
vol.
214
,
(
3
)
945
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948
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