Publications:  Dr Ann-Marie Baker

Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al.(2020). Cancer associated fibroblast FAK regulates malignant cell metabolism. Nature Communications vol. 11, (1) 1290-1290.

Baker AM, Graham TA(2020). Concurrent in situ analysis of point mutations and immune infiltrate in FFPE cancers. Methods in Enzymology, vol. 636,

Baker AM, Graham TA(2020). In Situ Point Mutation Detection in FFPE Colorectal Cancers Using the BaseScope Assay. vol. 2148, 349-360.

Baker AM, Cross W, Curtius K, Al Bakir I, Choi CHR, Davis HL, Temko D, Biswas S et al.(2019). Evolutionary history of human colitis-associated colorectal cancer. Gut vol. 68, (6) 985-995.

Baker AM, Gabbutt C, Williams MJ, Cereser B, Jawad N, Rodriguez-Justo M, Jansen M, Barnes CP et al.(2019). Crypt fusion as a homeostatic mechanism in the human colon. Gut vol. 68, (11) 1986-1993.

Cross W, Kovac M, Mustonen V, Temko D, Davis H, Baker A-M, Biswas S, Arnold R et al.(2018). The evolutionary landscape of colorectal tumorigenesis. Nat Ecol Evol vol. 2, (10) 1661-1672.

Temko D, Van Gool IC, Rayner E, Glaire M, Makino S, Brown M, Chegwidden L, Palles C et al.(2018). Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response. J Pathol vol. 245, (3) 283-296.

Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al.(2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports vol. 22, (9) 2469-2481.

Baker A-M, Huang W, Wang X-MM, Jansen M, Ma X-J, Kim J, Anderson CM, Wu X et al.(2017). Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution. Nat Commun vol. 8, (1) 1998-1998.

Sundaresan S, Meininger CA, Kang AJ, Photenhauer AL, Hayes MM, Sahoo N, Grembecka J, Cierpicki T et al.(2017). Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Gastroenterology vol. 153, (6) 1555-1567.e15.

Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM et al.(2017). The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1. Oncotarget vol. 8, (13) 21609-21625.

Martinez P, Timmer MR, Lau CT, Calpe S, Sancho-Serra MDC, Straub D, Baker A-M, Meijer SL et al.(2016). Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus. Nature Communications vol. 7, 12158-12158.

Baker AM, Van Noorden S, Rodriguez-Justo M, Cohen P, Wright NA, Lampert IA(2016). Distribution of the c-MYC gene product in colorectal neoplasia. Histopathology vol. 69, (2) 222-229.

Baker AM, Graham TA(2016). Quantifying human intestinal stem cell and crypt dynamics: The implications for cancer screening and prevention. Expert Review of Gastroenterology and Hepatology vol. 10, (3) 277-279.

Gay L, Baker AM, Graham TA(2016). Tumour Cell Heterogeneity. F1000Research vol. 5,

Baker AM, Graham TA, Elia G, Wright NA, Rodriguez-Justo M(2015). Characterization of LGR5 stem cells in colorectal adenomas and carcinomas. Scientific Reports vol. 5,

Baker AM, Graham TA(2014). Revealing human intestinal stem cell and crypt dynamics. Molecular and Cellular Oncology vol. 1, (3)

Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G et al.(2014). Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Reports vol. 8, (4) 940-947.

Cereser B, Baker A-MC, Tadrous PJ, Humphries A, Novelli M, Rodriguez-Justo M, Graham TA, McDonald SA et al. (2013). PWE-157 Two Dimensional Mapping of Mutant Clones in Human Colonic Crypts Reveal Stem Cell Dynamics and Migration Patterns. Gut. vol. 62,

Baker A-M, Bird D, Lang G, Cox TR, Erler JT(2013). Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. Oncogene vol. 32, (14) 1863-1868.

Cox TR, Bird D, Baker A-M, Barker HE, Ho MW-Y, Lang G, Erler JT(2013). LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis. Cancer Res vol. 73, (6) 1721-1732.

Baker AM, Graham TA, Wright NA(2013). Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: Potential for biomarker development. Journal of Pathology vol. 229, (4) 502-514.

Baker A-M, Bird D, Welti JC, Gourlaouen M, Lang G, Murray GI, Reynolds AR, Cox TR et al.(2013). Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis. Cancer Res vol. 73, (2) 583-594.

Baker A-M, Cox TR, Bird D, Lang G, Murray GI, Sun X-F, Southall SM, Wilson JR et al.(2011). The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst vol. 103, (5) 407-424.