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Research

Publications: Dr Philippa Williams

Oza E, Williams P, Kamra L ( 2024 ) . Digital denizenship: Hindu nationalist architectures of digital closings and unbelonging in India . Environment and Planning C Politics and Space
Green MJ, Murray EJ, Williams P, Ghaemmaghami AM, Aylott JW, Williams PM ( 2023 ) . Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing . International Journal of Molecular Sciences vol. 24 , ( 21 )
Mellini M, Letizia M, Caruso L, Guiducci A, Meneghini C, Heeb S, Williams P, Cámara M et al. ( 2023 ) . RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing . mBio vol. 14 , ( 6 ) e02039 - e02023 .
Williams P, Hill P, Bonev B, Chan WC ( 2023 ) . Quorum-sensing, intra- and inter-species competition in the staphylococci . Microbiology vol. 169 , ( 8 )
Khateb H, Hook AL, Kern S, Watts JA, Singh S, Jackson D, Marinez-Pomares L, Williams P et al. ( 2023 ) . Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS . Biointerphases vol. 18 , ( 3 )
Ottonello A, Wyllie JA, Yahiaoui O, Sun S, Koelln RA, Homer JA, Johnson RM, Murray E et al. ( 2023 ) . Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria . Proceedings of the National Academy of Sciences of the United States of America vol. 120 , ( 15 )
Kamra L, Williams P, Johar P ( 2023 ) . Grassroots authoritarianism: WhatsApp, middle-class boundary-making and pandemic governance in New Delhi’s neighbourhoods . Territory Politics Governance vol. 11 , ( 6 ) 1121 - 1140 .
Dubern J-F, Hook AL, Carabelli AM, Chang C-Y, Lewis-Lloyd CA, Luckett JC, Burroughs L, Dundas AA et al. ( 2023 ) . Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation . Science Advances vol. 9 , ( 4 )
Dubern J-F, Romero M, Mai-Prochnow A, Messina M, Trampari E, Gijzel HN-V, Chan K-G, Carabelli AM et al. ( 2022 ) . ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa . npj Biofilms and Microbiomes vol. 8 , ( 1 )
Peng Z, Maciel-Guerra A, Baker M, Zhang X, Hu Y, Wang W, Rong J, Zhang J et al. ( 2022 ) . Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming . PLOS Computational Biology vol. 18 , ( 3 )
Murray EJ, Dubern J-F, Chan WC, Chhabra SR, Williams P ( 2022 ) . A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin . Cell Chemical Biology vol. 29 , ( 7 ) 1187 - 1199.e6 .
Webb K, Zain NMM, Stewart I, Fogarty A, Nash EF, Whitehouse JL, Smyth AR, Lilley AK et al. ( 2022 ) . Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis . Journal of Medical Microbiology vol. 71 , ( 2 )
He Y, Luckett J, Begines B, Dubern J-F, Hook AL, Prina E, Rose FRAJ, Tuck CJ et al. ( 2021 ) . Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices . Biomaterials vol. 281 ,
Singh S, Almuhanna Y, Alshahrani MY, Lowman DW, Rice PJ, Gell C, Ma Z, Graves B et al. ( 2021 ) . Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function . npj Biofilms and Microbiomes vol. 7 , ( 1 )
Tarantini FS, Brunati M, Taravella A, Carrano L, Parenti F, Hong KW, Williams P, Chan KG et al. ( 2021 ) . Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin . PLOS ONE vol. 16 , ( 11 )
Zain NMM, Webb K, Stewart I, Halliday N, Barrett DA, Nash EF, Whitehouse JL, Honeybourne D et al. ( 2021 ) . 2-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent Pseudomonas aeruginosa burden in adults with cystic fibrosis . Journal of Medical Microbiology vol. 70 , ( 10 )
Webb K, Cámara M, Zain NMM, Halliday N, Bruce KD, Nash EF, Whitehouse JL, Knox A et al. ( 2021 ) . Novel detection of specific bacterial quorum sensing molecules in saliva: Potential non-invasive biomarkers for pulmonary Pseudomonas aeruginosa in cystic fibrosis . Journal of Cystic Fibrosis vol. 21 , ( 4 ) 626 - 629 .
Soh EY-C, Smith F, Gimenez MR, Yang L, Vejborg RM, Fletcher M, Halliday N, Bleves S et al. ( 2021 ) . Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1 sub-unit . PLOS Pathogens vol. 17 , ( 8 )
Vermeulen S, Honig F, Vasilevich A, Roumans N, Romero M, Eren AD, Tuvshindorj U, Alexander M et al. ( 2021 ) . Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction . Advanced Materials vol. 33 , ( 31 )
Nazik H, Sass G, Williams P, Déziel E, Stevens DA ( 2021 ) . Molecular Modifications of the Pseudomonas Quinolone Signal in the Intermicrobial Competition with Aspergillus . Journal of Fungi vol. 7 , ( 5 )
Fenn S, Dubern J-F, Cigana C, De Simone M, Lazenby J, Juhas M, Schwager S, Bianconi I et al. ( 2021 ) . NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target . mBio vol. 12 , ( 2 ) e00207 - e00221 .
López-Martín M, Dubern J-F, Alexander MR, Williams P ( 2021 ) . AbaM Regulates Quorum Sensing, Biofilm Formation, and Virulence in Acinetobacter baumannii . Journal of Bacteriology vol. 203 , ( 8 ) e00635 - e00620 .
Green MJ, Aylott JW, Williams P, Ghaemmaghami AM, Williams PM ( 2021 ) . Immunity in Space: Prokaryote Adaptations and Immune Response in Microgravity . Life vol. 11 , ( 2 )
Blower I, Tong C, Sun X, Murray E, Luckett J, Chan W, Williams P, Hill P ( 2020 ) . Gaussia Luciferase as a Reporter for Quorum Sensing in Staphylococcus aureus . Sensors vol. 20 , ( 15 )
Vassey MJ, Figueredo GP, Scurr DJ, Vasilevich AS, Vermeulen S, Carlier A, Luckett J, Beijer NRM et al. ( 2020 ) . Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation . Advanced Science vol. 7 , ( 11 )
Kurmoo Y, Hook AL, Harvey D, Dubern J-F, Williams P, Morgan SP, Korposh S, Alexander MR ( 2020 ) . Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections . Biomaterials Science vol. 8 , ( 5 ) 1464 - 1477 .
Hook AL, Flewellen JL, Dubern J-F, Carabelli AM, Zaid IM, Berry RM, Wildman RD, Russell N et al. ( 2019 ) . Simultaneous Tracking of Pseudomonas aeruginosa Motility in Liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators . mSystems vol. 4 , ( 5 ) e00390 - e00319 .
Sloan TJ, Murray E, Yokoyama M, Massey RC, Chan WC, Bonev BB, Williams P ( 2019 ) . Timing Is Everything: Impact of Naturally Occurring Staphylococcus aureus AgrC Cytoplasmic Domain Adaptive Mutations on Autoinduction . Journal of Bacteriology vol. 201 , ( 20 ) e00409 - e00419 .
Singh N, Romero M, Travanut A, Monteiro PF, Jordana-Lluch E, Hardie KR, Williams P, Alexander MR et al. ( 2019 ) . Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo . Biomaterials Science vol. 7 , ( 10 ) 4099 - 4111 .
Featherstone D, Bjorkdahl A, Chatterjee I, Jazeel T, Williams P ( 2019 ) . Everyday Peace? Politics, Citizenship and Muslim lives in India .
Featherstone D, Björkdahl A, Chatterjee I, Jazeel T, Williams P ( 2019 ) . Philippa Williams Everyday Peace? Politics, Citizenship and Muslim lives in India 2015 Wiley Blackwell RGS-IBG Book Series . Elsevier
Featherstone D, Björkdahl A, Chatterjee I, Jazeel T, Williams P ( 2019 ) . Review forum . Elsevier BV
WILLIAMS PJ ( 2018 ) . Emigration state encounters: The everyday material life of a diaspora technology . Political Geography vol. 68 , 1 - 11 .
Yokoyama M, Stevens E, Laabei M, Bacon L, Heesom K, Bayliss S, Ooi N, O’Neill AJ et al. ( 2018 ) . Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA . Genome Biology vol. 19 , ( 1 )
Ng Y-K, Grasso M, Wright V, Garcia V, Williams P, Atkinson S ( 2018 ) . The Quorum Sensing System of Yersinia enterocolitica 8081 Regulates Swimming Motility, Host Cell Attachment, and Virulence Plasmid Maintenance . Genes vol. 9 , ( 6 )
Romero M, Silistre H, Lovelock L, Wright VJ, Chan K-G, Hong K-W, Williams P, Cámara M et al. ( 2018 ) . Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN . Nucleic Acids Research vol. 46 , ( 13 )
Hussain R, Hughes CS, Jávorfi T, Siligardi G, Williams P, Bonev BB ( 2018 ) . To Boil an Egg: Substrate Binding Affects Critical Stability in Thermal Unfolding of Proteins . The Journal of Physical Chemistry B vol. 122 , ( 8 ) 2213 - 2218 .
Soukarieh F, Oton EV, Dubern J-F, Gomes J, Halliday N, de Pilar Crespo M, Ramírez-Prada J, Insuasty B et al. ( 2018 ) . In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa . Molecules vol. 23 , ( 2 )
Mikulskis P, Hook A, Dundas AA, Irvine D, Sanni O, Anderson D, Langer R, Alexander MR et al. ( 2018 ) . Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices . ACS Applied Materials & Interfaces vol. 10 , ( 1 ) 139 - 149 .
Hüsler A, Haas S, Parry L, Romero M, Nisisako T, Williams P, Wildman RD, Alexander MR ( 2018 ) . Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films . RSC Advances vol. 8 , ( 28 ) 15352 - 15357 .
Williams P ( 2018 ) . IN THE PUBLIC'S INTEREST: Evictions, Citizenship, and Inequality in Contemporary Delhi. <i>Geographies of Justice and Social Transformation</i> . PACIFIC AFFAIRS vol. 91 , ( 3 ) 622 - 624 .
Fletcher MP, Diggle SP, Cámara M, Williams P ( 2017 ) . Detection of 2-Alkyl-4-Quinolones Using Biosensors . Quorum Sensing , vol. 1673 , Springer Nature
Murray EJ, Williams P ( 2017 ) . Detection of Agr-Type Autoinducing Peptides Produced by Staphylococcus aureus . Quorum Sensing , vol. 1673 , Springer Nature
Barr HL, Cámara M, Barrett D, Williams P, Forrester D, Smyth A, Honeybourne D, Whitehouse J et al. ( 2017 ) . Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis . ERJ Open Research vol. 3 , ( 3 ) 00057 - 02017 .
Heeb S, Càmara M, Filloux A, Williams P ( 2017 ) . Professor Dieter Haas (1945–2017) . FEMS Microbiology Reviews vol. 41 , ( 5 ) 597 - 598 .
Alexander MR, Williams P ( 2017 ) . Water contact angle is not a good predictor of biological responses to materials . Biointerphases vol. 12 , ( 2 )
Williams P ( 2017 ) . Particulate air pollution impacts directly on bacterial pathogen behaviour and infection . Environmental Microbiology vol. 19 , ( 10 ) 3787 - 3788 .
Tyler BJ, Hook A, Pelster A, Williams P, Alexander M, Arlinghaus HF ( 2017 ) . Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating . Biointerphases vol. 12 , ( 2 )
Popat R, Harrison F, da Silva AC, Easton SAS, McNally L, Williams P, Diggle SP ( 2017 ) . Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production . Proceedings of the Royal Society B vol. 284 , ( 1852 )
WILLIAMS PJ ( 2017 ) . Moral Geography . International Encyclopedia of Geography, 15 Volume Set People, the Earth, Environment and Technology , John Wiley & Sons
Devescovi G, Kojic M, Covaceuszach S, Cámara M, Williams P, Bertani I, Subramoni S, Venturi V ( 2017 ) . Negative Regulation of Violacein Biosynthesis in Chromobacterium violaceum . Frontiers in Microbiology vol. 8 ,
Williams P, James A, McConnell F, Vira B ( 2017 ) . Working at the margins? Muslim middle class professionals in India and the limits of "labour agency' . ENVIRONMENT AND PLANNING A vol. 49 , ( 6 ) 1266 - 1285 .
Zapotoczna M, Murray EJ, Hogan S, O’Gara JP, Chhabra SR, Chan WC, O’Neill E, Williams P ( 2016 ) . 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus . Journal of Antimicrobial Chemotherapy vol. 72 , ( 3 ) 744 - 753 .
Rampioni G, Falcone M, Heeb S, Frangipani E, Fletcher MP, Dubern J-F, Visca P, Leoni L et al. ( 2016 ) . Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa . PLOS Pathogens vol. 12 , ( 11 )
Magennis EP, Hook AL, Williams P, Alexander MR ( 2016 ) . Making Silicone Rubber Highly Resistant to Bacterial Attachment Using Thiol-ene Grafting . ACS Applied Materials & Interfaces vol. 8 , ( 45 ) 30780 - 30787 .
Ruparell A, Dubern JF, Ortori CA, Harrison F, Halliday NM, Emtage A, Ashawesh MM, Laughton CA et al. ( 2016 ) . The fitness burden imposed by synthesising quorum sensing signals . Scientific Reports vol. 6 , ( 1 )
Gan HM, Dailey LK, Halliday N, Williams P, Hudson AO, Savka MA ( 2016 ) . Genome sequencing-assisted identification and the first functional validation of N-acyl-homoserine-lactone synthases from the Sphingomonadaceae family . PeerJ vol. 4 ,
Adlington K, Nguyen NT, Eaves E, Yang J, Chang C-Y, Li J, Gower AL, Stimpson A et al. ( 2016 ) . Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers . Biomacromolecules vol. 17 , ( 9 ) 2830 - 2838 .
Nguyen AT, Jones JW, Cámara M, Williams P, Kane MA, Oglesby-Sherrouse AG ( 2016 ) . Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones . Frontiers in Microbiology vol. 7 ,
Atkinson S, Williams P ( 2016 ) . Yersinia virulence factors - a sophisticated arsenal for combating host defences . F1000Research vol. 5 ,
WILLIAMS PJ ( 2016 ) . Geography and Peace . The Palgrave Handbook of Disciplinary and Regional Approaches to Peace , Springer
Drees SL, Li C, Prasetya F, Saleem M, Dreveny I, Williams P, Hennecke U, Emsley J et al. ( 2016 ) . PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM* ♦ . Journal of Biological Chemistry vol. 291 , ( 13 ) 6610 - 6624 .
Butt A, Halliday N, Williams P, Atkins HS, Bancroft GJ, Titball RW ( 2015 ) . Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence . Research in Microbiology vol. 167 , ( 3 ) 159 - 167 .
Magennis EP, Hook AL, Davies MC, Alexander C, Williams P, Alexander MR ( 2015 ) . Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment . Acta Biomaterialia vol. 34 , 84 - 92 .
Williams P ( 2015 ) . Everyday Peace Politics, Citizenship and Muslim Lives in India . John Wiley & Sons
Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont M-J, Laroche J, Larose S, Maaroufi H et al. ( 2015 ) . Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium . Frontiers in Microbiology vol. 6 ,
Popat R, Pollitt EJG, Harrison F, Naghra H, Hong K, Chan K, Griffin AS, Williams P et al. ( 2015 ) . Conflict of interest and signal interference lead to the breakdown of honest signaling . Evolution vol. 69 , ( 9 ) 2371 - 2383 .
Barr HL, Halliday N, Cámara M, Barrett DA, Williams P, Forrester DL, Simms R, Smyth AR et al. ( 2015 ) . Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis . European Respiratory Journal . vol. 46 , 1046 - 1054 .
Dubern J-F, Cigana C, De Simone M, Lazenby J, Juhas M, Schwager S, Bianconi I, Döring G et al. ( 2015 ) . Multi‐host Pseudomonas aeruginosa virulence . Environmental Microbiology vol. 17 , ( 11 ) 4379 - 4393 .
Soh EY-C, Chhabra SR, Halliday N, Heeb S, Müller C, Birmes FS, Fetzner S, Cámara M et al. ( 2015 ) . PQS inactivation . Environmental Microbiology vol. 17 , ( 11 ) 4352 - 4365 .
Mills B, Awais RO, Luckett J, Turton D, Williams P, Perkins AC, Hill PJ ( 2015 ) . [18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections . EJNMMI Research vol. 5 , ( 1 )
Singh S, Barr H, Liu Y-C, Robins A, Heeb S, Williams P, Fogarty A, Cámara M et al. ( 2015 ) . Granulocyte-Macrophage Colony Stimulatory Factor Enhances the Pro-Inflammatory Response of Interferon-γ-Treated Macrophages to Pseudomonas aeruginosa Infection . PLOS ONE vol. 10 , ( 2 )
Ee R, Ambrose M, Lazenby J, Williams P, Chan K-G, Roddam L ( 2015 ) . Genome Sequences of Two Pandoraea pnomenusa Isolates Recovered 11 Months Apart from a Cystic Fibrosis Patient . Microbiology Resource Announcements vol. 3 , ( 1 ) e01389 - e01314 .
Karavolos MH, Williams P, Khan CMA ( 2014 ) . Interkingdom crosstalk . Virulence vol. 2 , ( 4 ) 371 - 374 .
Joshua GWP, Atkinson S, Goldstone RJ, Patrick HL, Stabler RA, Purves J, Cámara M, Williams P et al. ( 2014 ) . Genome-Wide Evaluation of the Interplay between Caenorhabditis elegans and Yersinia pseudotuberculosis during In Vivo Biofilm Formation . Infection and Immunity vol. 83 , ( 1 ) 17 - 27 .
DESOUKY SE, NISHIGUCHI K, ZENDO T, IGARASHI Y, WILLIAMS P, SONOMOTO K, NAKAYAMA J ( 2014 ) . High-Throughput Screening of Inhibitors Targeting Agr/Fsr Quorum Sensing in Staphylococcus aureus and Enterococcus faecalis . Bioscience Biotechnology and Biochemistry vol. 77 , ( 5 ) 923 - 927 .
Rampioni G, Leoni L, Williams P ( 2014 ) . The art of antibacterial warfare: Deception through interference with quorum sensing–mediated communication . Bioorganic Chemistry vol. 55 , 60 - 68 .
Laabei M, Recker M, Rudkin JK, Aldeljawi M, Gulay Z, Sloan TJ, Williams P, Endres JL et al. ( 2014 ) . Predicting the virulence of MRSA from its genome sequence . Genome Research vol. 24 , ( 5 ) 839 - 849 .
Fletcher M, Cámara M, Barrett DA, Williams P ( 2014 ) . Biosensors for Qualitative and Semiquantitative Analysis of Quorum Sensing Signal Molecules . vol. 1149 , 245 - 254 .
Ortori CA, Halliday N, Cámara M, Williams P, Barrett DA ( 2014 ) . LC-MS/MS Quantitative Analysis of Quorum Sensing Signal Molecules . vol. 1149 , 255 - 270 .
McConnell F, Megoran N, Williams P ( 2014 ) . The Geographies of Peace New Approaches to Boundaries, Diplomacy and Conflict Resolution . I.B.Tauris
Murray EJ, Crowley RC, Truman A, Clarke SR, Cottam JA, Jadhav GP, Steele VR, O’Shea P et al. ( 2014 ) . Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors . Journal of Medicinal Chemistry vol. 57 , ( 6 ) 2813 - 2819 .
Hook AL, Chang C, Scurr DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR ( 2014 ) . Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment . Advanced Healthcare Materials vol. 3 , ( 7 ) 1020 - 1025 .
Williams P ( 2014 ) . INDIA TODAY: Economy, Politics and Society . PACIFIC AFFAIRS vol. 87 , ( 4 ) 877 - 879 .
Morris ER, Hall G, Li C, Heeb S, Kulkarni RV, Lovelock L, Silistre H, Messina M et al. ( 2013 ) . Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN . Structure vol. 21 , ( 9 ) 1659 - 1671 .
Ilangovan A, Fletcher M, Rampioni G, Pustelny C, Rumbaugh K, Heeb S, Cámara M, Truman A et al. ( 2013 ) . Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR) . PLOS Pathogens vol. 9 , ( 7 )
Twigg MS, Tait K, Williams P, Atkinson S, Cámara M ( 2013 ) . Ulva zoospore germination and AHLs . Environmental Microbiology vol. 16 , ( 2 ) 445 - 453 .
Lee J, Wu J, Deng Y, Wang J, Wang C, Wang J, Chang C, Dong Y et al. ( 2013 ) . A cell-cell communication signal integrates quorum sensing and stress response . Nature Chemical Biology vol. 9 , ( 5 ) 339 - 343 .
Hook AL, Chang C, Yang J, Atkinson S, Langer R, Anderson DG, Davies MC, Williams P et al. ( 2013 ) . Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays . Advanced Materials vol. 25 , ( 18 ) 2542 - 2547 .
Gordon CP, Williams P, Chan WC ( 2013 ) . Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective . Journal of Medicinal Chemistry vol. 56 , ( 4 ) 1389 - 1404 .
WILLIAMS PJ ( 2013 ) . Reproducing everyday peace in north India: process, politics and power . Annals of the Association of American Geographers vol. 103 , ( 1 ) 230 - 250 .
Karavolos MH, Winzer K, Williams P, Khan CMA ( 2012 ) . Pathogen–host communication . Molecular Microbiology vol. 87 , ( 3 ) 455 - 465 .
WILLIAMS PJ ( 2012 ) . India's Muslims, lived secularism and realising citizenship . Citizenship Studies vol. 16 , ( 8 ) 979 - 955 .
Popat R, Crusz SA, Messina M, Williams P, West SA, Diggle SP ( 2012 ) . Quorum-sensing and cheating in bacterial biofilms . Proceedings of the Royal Society B vol. 279 , ( 1748 ) 4765 - 4771 .
Hook AL, Chang C-Y, Yang J, Luckett J, Cockayne A, Atkinson S, Mei Y, Bayston R et al. ( 2012 ) . Combinatorial discovery of polymers resistant to bacterial attachment . Nature Biotechnology vol. 30 , ( 9 ) 868 - 875 .
Crusz SA, Popat R, Rybtke MT, Cámara M, Givskov M, Tolker-Nielsen T, Diggle SP, Williams P ( 2012 ) . Bursting the bubble on bacterial biofilms: a flow cell methodology . Biofouling vol. 28 , ( 8 ) 835 - 842 .
Hook AL, Scurr DJ, Anderson DG, Langer R, Williams P, Davies M, Alexander M ( 2013 ) . High throughput discovery of thermo‐responsive materials using water contact angle measurements and time‐of‐flight secondary ion mass spectrometry . Surface and Interface Analysis . vol. 45 , 181 - 184 .
Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters EM, Chan WC, Williams P et al. ( 2012 ) . Methicillin Resistance Reduces the Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by Interfering With the agr Quorum Sensing System . The Journal of Infectious Diseases vol. 205 , ( 5 ) 798 - 806 .
Hook AL, Chang C-Y, Yang J, Scurr DJ, Langer R, Anderson DG, Atkinson S, Williams P et al. ( 2012 ) . Polymer Microarrays for High Throughput Discovery of Biomaterials . Journal of Visualized Experiments ( 59 )
Wei Q, Tarighi S, Dötsch A, Häussler S, Müsken M, Wright VJ, Cámara M, Williams P et al. ( 2011 ) . Phenotypic and Genome-Wide Analysis of an Antibiotic-Resistant Small Colony Variant (SCV) of Pseudomonas aeruginosa . PLOS ONE vol. 6 , ( 12 )
Jabbari S, King JR, Williams P ( 2011 ) . Cross-Strain Quorum Sensing Inhibition by Staphylococcus Aureus. Part 2: A Spatially Inhomogeneous Model . Bulletin of Mathematical Biology vol. 74 , ( 6 ) 1326 - 1353 .
Jabbari S, King JR, Williams P ( 2011 ) . Cross-Strain Quorum Sensing Inhibition by Staphylococcus aureus. Part 1: A Spatially Homogeneous Model . Bulletin of Mathematical Biology vol. 74 , ( 6 ) 1292 - 1325 .
Moscoso JA, Mikkelsen H, Heeb S, Williams P, Filloux A ( 2011 ) . The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c‐di‐GMP signalling . Environmental Microbiology vol. 13 , ( 12 ) 3128 - 3138 .
Kadam RU, Bergmann M, Hurley M, Garg D, Cacciarini M, Swiderska MA, Nativi C, Sattler M et al. ( 2011 ) . A Glycopeptide Dendrimer Inhibitor of the Galactose‐Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms . Angewandte Chemie International Edition vol. 50 , ( 45 ) 10631 - 10635 .
Niewerth H, Bergander K, Chhabra SR, Williams P, Fetzner S ( 2011 ) . Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440 . Applied Microbiology and Biotechnology vol. 91 , ( 5 )
Williams P ( 2011 ) . Hindu–Muslim Relations and the “War on Terror” . A Companion to the Anthropology of India , Wiley
Jadhav GP, Chhabra SR, Telford G, Hooi DSW, Righetti K, Williams P, Kellam B, Pritchard DI et al. ( 2011 ) . Immunosuppressive but Non-LasR-Inducing Analogues of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxododecanoyl)-l-homoserine Lactone . Journal of Medicinal Chemistry vol. 54 , ( 9 ) 3348 - 3359 .
Williams P ( 2011 ) . Compromising Bacterial Communication Skills* . Journal of Pharmacy and Pharmacology vol. 46 , ( 4 ) 252 - 260 .
Sonnleitner E, Gonzalez N, Sorger‐Domenigg T, Heeb S, Richter AS, Backofen R, Williams P, Hüttenhofer A et al. ( 2011 ) . The small RNA PhrS stimulates synthesis of the Pseudomonas aeruginosa quinolone signal . Molecular Microbiology vol. 80 , ( 4 ) 868 - 885 .
Chan K-G, Atkinson S, Mathee K, Sam C-K, Chhabra SR, Cámara M, Koh C-L, Williams P ( 2011 ) . Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: Co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia . BMC Microbiology vol. 11 , ( 1 )
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Cámara M ( 2011 ) . Quinolones: from antibiotics to autoinducers . FEMS Microbiology Reviews vol. 35 , ( 2 ) 247 - 274 .
Karavolos MH, Bulmer DM, Spencer H, Rampioni G, Schmalen I, Baker S, Pickard D, Gray J et al. ( 2011 ) . Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E . EMBO Reports vol. 12 , ( 3 ) 252 - 258 .
Hothersall J, Murphy AC, Iqbal Z, Campbell G, Stephens ER, Wu J, Cooper H, Atkinson S et al. ( 2011 ) . Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production . Applied Microbiology and Biotechnology vol. 90 , ( 3 ) 1017 - 1026 .
Czajkowski R, Krzyżanowska D, Karczewska J, Atkinson S, Przysowa J, Lojkowska E, Williams P, Jafra S ( 2011 ) . Inactivation of AHLs by Ochrobactrum sp. A44 depends on the activity of a novel class of AHL acylase . Environmental Microbiology Reports vol. 3 , ( 1 ) 59 - 68 .
Atkinson S, Goldstone RJ, Joshua GWP, Chang C-Y, Patrick HL, Cámara M, Wren BW, Williams P ( 2011 ) . Biofilm Development on Caenorhabditis elegans by Yersinia Is Facilitated by Quorum Sensing-Dependent Repression of Type III Secretion . PLOS Pathogens vol. 7 , ( 1 )
WILLIAMS PJ ( 2011 ) . An absent presence: experiences of the 'welfare state' in an Indian Muslim mohalla . Contemporary South Asia vol. 3 , ( 19 ) 263 - 280 .
Ortori CA, Dubern J-F, Chhabra SR, Cámara M, Hardie K, Williams P, Barrett DA ( 2010 ) . Simultaneous quantitative profiling of N-acyl-l-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS . Analytical and Bioanalytical Chemistry vol. 399 , ( 2 ) 839 - 850 .
Davis BM, Jensen R, Williams P, O'Shea P ( 2010 ) . The Interaction of N-Acylhomoserine Lactone Quorum Sensing Signaling Molecules with Biological Membranes: Implications for Inter-Kingdom Signaling . PLOS ONE vol. 5 , ( 10 )
Diggle SP, Fletcher MP, Cámara M, Williams P ( 2010 ) . Detection of 2-Alkyl-4-Quinolones Using Biosensors . Quorum Sensing , vol. 692 , Springer Nature
Rampioni G, Pustelny C, Fletcher MP, Wright VJ, Bruce M, Rumbaugh KP, Heeb S, Cámara M et al. ( 2010 ) . Transcriptomic analysis reveals a global alkyl‐quinolone‐independent regulatory role for PqsE in facilitating the environmental adaptation of Pseudomonas aeruginosa to plant and animal hosts . Environmental Microbiology vol. 12 , ( 6 ) 1659 - 1673 .
Koch G, Jimenez PN, Muntendam R, Chen Y, Papaioannou E, Heeb S, Cámara M, Williams P et al. ( 2010 ) . The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp . Environmental Microbiology Reports vol. 2 , ( 3 ) 433 - 439 .
Halliday NM, Hardie KR, Williams P, Winzer K, Barrett DA ( 2010 ) . Quantitative liquid chromatography–tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli . Analytical Biochemistry vol. 403 , ( 1-2 ) 20 - 29 .
Smyth AR, Cifelli PM, Ortori CA, Righetti K, Lewis S, Erskine P, Holland ED, Givskov M et al. ( 2010 ) . Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis—a pilot randomized controlled trial . Pediatric Pulmonology vol. 45 , ( 4 ) 356 - 362 .
Jabbari S, King JR, Williams P ( 2010 ) . A mathematical investigation of the effects of inhibitor therapy on three putative phosphorylation cascades governing the two-component system of the agr operon . Mathematical Biosciences vol. 225 , ( 2 ) 115 - 131 .
Kadirvel M, Stimpson WT, Moumene-Afifi S, Arsic B, Glynn N, Halliday N, Williams P, Gilbert P et al. ( 2010 ) . Synthesis and bioluminescence-inducing properties of autoinducer (S)-4,5-dihydroxypentane-2,3-dione and its enantiomer . Bioorganic & Medicinal Chemistry Letters vol. 20 , ( 8 ) 2625 - 2628 .
Pustelny C, Albers A, Büldt-Karentzopoulos K, Parschat K, Chhabra SR, Cámara M, Williams P, Fetzner S ( 2009 ) . Dioxygenase-Mediated Quenching of Quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa . Cell Chemical Biology vol. 16 , ( 12 ) 1259 - 1267 .
Spencer H, Karavolos MH, Bulmer DM, Aldridge P, Chhabra SR, Winzer K, Williams P, Khan CMA ( 2009 ) . Genome-Wide Transposon Mutagenesis Identifies a Role for Host Neuroendocrine Stress Hormones in Regulating the Expression of Virulence Genes in Salmonella▿ . Journal of Bacteriology vol. 192 , ( 3 ) 714 - 724 .
Hook AL, Anderson DG, Langer R, Williams P, Davies MC, Alexander MR ( 2009 ) . High throughput methods applied in biomaterial development and discovery . Biomaterials vol. 31 , ( 2 ) 187 - 198 .
Perrett CA, Karavolos MH, Humphrey S, Mastroeni P, Martinez-Argudo I, Spencer H, Bulmer D, Winzer K et al. ( 2009 ) . LuxS-Based Quorum Sensing Does Not Affect the Ability of Salmonella enterica Serovar Typhimurium To Express the SPI-1 Type 3 Secretion System, Induce Membrane Ruffles, or Invade Epithelial Cells ▿ . Journal of Bacteriology vol. 191 , ( 23 ) 7253 - 7259 .
Ramsay JP, Sullivan JT, Jambari N, Ortori CA, Heeb S, Williams P, Barrett DA, Lamont IL et al. ( 2009 ) . A LuxRI‐family regulatory system controls excision and transfer of the Mesorhizobium loti strain R7A symbiosis island by activating expression of two conserved hypothetical genes . Molecular Microbiology vol. 73 , ( 6 ) 1141 - 1155 .
Jabbari S, King JR, Koerber AJ, Williams P ( 2009 ) . Mathematical modelling of the agr operon in Staphylococcus aureus . Journal of Mathematical Biology vol. 61 , ( 1 ) 17 - 54 .
Atkinson S, Williams P ( 2009 ) . Quorum sensing and social networking in the microbial world . Journal of The Royal Society Interface vol. 6 , ( 40 ) 959 - 978 .
Tait K, Williamson H, Atkinson S, Williams P, Cámara M, Joint I ( 2009 ) . Turnover of quorum sensing signal molecules modulates cross‐kingdom signalling . Environmental Microbiology vol. 11 , ( 7 ) 1792 - 1802 .
Ding L, Wang Y, Hu Y, Atkinson S, Williams P, Chen S ( 2009 ) . Functional characterization of FlgM in the regulation of flagellar synthesis and motility in Yersinia pseudotuberculosis . Microbiology vol. 155 , ( 6 ) 1890 - 1900 .
Skindersoe ME, Zeuthen LH, Brix S, Fink LN, Lazenby J, Whittall C, Williams P, Diggle SP et al. ( 2009 ) . Pseudomonas aeruginosa quorum‐sensing signal molecules interfere with dendritic cell‐induced T‐cell proliferation . Pathogens and Disease vol. 55 , ( 3 ) 335 - 345 .
Williams P, Cámara M ( 2009 ) . Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules . Current Opinion in Microbiology vol. 12 , ( 2 ) 182 - 191 .
Gardiner SM, Chhabra SR, Harty C, Williams P, Pritchard DI, Bycroft BW, Bennett T ( 2009 ) . Haemodynamic effects of the bacterial quorum sensing signal molecule, N‐(3‐oxododecanoyl)‐L‐homoserine lactone, in conscious, normal and endotoxaemic rats . British Journal of Pharmacology vol. 133 , ( 7 ) 1047 - 1054 .
Lawrence RN, Dunn WR, Bycroft B, Camara M, Chhabra SR, Williams P, Wilson VG ( 2009 ) . The Pseudomonas aeruginosa quorum‐sensing signal molecule, N‐(3‐oxododecanoyl)‐L‐homoserine lactone, inhibits porcine arterial smooth muscle contraction . British Journal of Pharmacology vol. 128 , ( 4 ) 845 - 848 .
Johansson EMV, Crusz SA, Kolomiets E, Buts L, Kadam RU, Cacciarini M, Bartels K-M, Diggle SP et al. ( 2008 ) . Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB . Cell Chemical Biology vol. 15 , ( 12 ) 1249 - 1257 .
Boontham P, Robins A, Chandran P, Pritchard D, Cámara M, Williams P, Chuthapisith S, McKechnie A et al. ( 2008 ) . Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis . Clinical Science vol. 115 , ( 11 ) 343 - 351 .
Cooley M, Chhabra SR, Williams P ( 2008 ) . N-Acylhomoserine Lactone-Mediated Quorum Sensing: A Twist in the Tail and a Blow for Host Immunity . Cell Chemical Biology vol. 15 , ( 11 ) 1141 - 1147 .
Karavolos M, Spencer H, Bulmer D, Thompson A, Winzer K, Williams P, Hinton J, Khan CA ( 2008 ) . Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses . BMC Genomics vol. 9 , ( 1 )
Tarighi S, Wei Q, Cámara M, Williams P, Fletcher MP, Kajander T, Cornelis P ( 2008 ) . The PA4204 gene encodes a periplasmic gluconolactonase (PpgL) which is important for fitness of Pseudomonas aeruginosa . Microbiology vol. 154 , ( 10 ) 2979 - 2990 .
Lynch MJ, Swift S, Kirke DF, Keevil CW, Dodd CER, Williams P ( 2008 ) . The regulation of biofilm development by quorum sensing in Aeromonas hydrophila . Environmental Microbiology vol. 4 , ( 1 ) 18 - 28 .
Latifi A, Foglino M, Tanaka K, Williams P, Lazdunski A ( 2008 ) . A hierarchical quorum‐sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary‐phase sigma factor RpoS . Molecular Microbiology vol. 21 , ( 6 ) 1137 - 1146 .
Atkinson S, Chang C, Patrick HL, Buckley CMF, Wang Y, Sockett RE, Cámara M, Williams P ( 2008 ) . Functional interplay between the Yersinia pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression of flhDC and fliA . Molecular Microbiology vol. 69 , ( 1 ) 137 - 151 .
Jensen RO, Winzer K, Clarke SR, Chan WC, Williams P ( 2008 ) . Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC . Journal of Molecular Biology vol. 381 , ( 2 ) 300 - 309 .
Williams P ( 2007 ) . Quorum sensing, communication and cross-kingdom signalling in the bacterial world . Microbiology vol. 153 , ( 12 ) 3923 - 3938 .
Karavolos MH, Bulmer DM, Winzer K, Wilson M, Mastroeni P, Williams P, Khan CMA ( 2007 ) . LuxS Affects Flagellar Phase Variation Independently of Quorum Sensing in Salmonella enterica Serovar Typhimurium▿ . Journal of Bacteriology vol. 190 , ( 2 ) 769 - 771 .
Fletcher MP, Diggle SP, Crusz SA, Chhabra SR, Cámara M, Williams P ( 2007 ) . A dual biosensor for 2‐alkyl‐4‐quinolone quorum‐sensing signal molecules . Environmental Microbiology vol. 9 , ( 11 ) 2683 - 2693 .
Williams P ( 2007 ) . Bacillus subtilis: A Shocking Message from a Probiotic . Cell Host & Microbe vol. 1 , ( 4 ) 248 - 249 .
Fletcher MP, Diggle SP, Cámara M, Williams P ( 2007 ) . Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules . Nature Protocols vol. 2 , ( 5 ) 1254 - 1262 .
Jensen PØ, Bjarnsholt T, Phipps R, Rasmussen TB, Calum H, Christoffersen L, Moser C, Williams P et al. ( 2007 ) . Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa . Microbiology vol. 153 , ( 5 ) 1329 - 1338 .
Joint I, Downie JA, Williams P ( 2007 ) . Bacterial conversations: talking, listening and eavesdropping. An introduction . Philosophical Transactions of the Royal Society B Biological Sciences vol. 362 , ( 1483 ) 1115 - 1117 .
Williams P, Winzer K, Chan WC, Cmara M ( 2007 ) . Look who's talking: communication and quorum sensing in the bacterial world . Philosophical Transactions of the Royal Society B Biological Sciences vol. 362 , ( 1483 ) 1119 - 1134 .
Diggle SP, Matthijs S, Wright VJ, Fletcher MP, Chhabra SR, Lamont IL, Kong X, Hider RC et al. ( 2007 ) . The Pseudomonas aeruginosa 4-Quinolone Signal Molecules HHQ and PQS Play Multifunctional Roles in Quorum Sensing and Iron Entrapment . Cell Chemical Biology vol. 14 , ( 1 ) 87 - 96 .
Van Houdt R, Moons P, Aertsen A, Jansen A, Vanoirbeek K, Daykin M, Williams P, Michiels CW ( 2006 ) . Characterization of a luxI/luxR-type quorum sensing system and N-acyl-homoserine lactone-dependent regulation of exo-enzyme and antibacterial component production in Serratia plymuthica RVH1 . Research in Microbiology vol. 158 , ( 2 ) 150 - 158 .
Lumjiaktase P, Diggle SP, Loprasert S, Tungpradabkul S, Daykin M, Cámara M, Williams P, Kunakorn M ( 2006 ) . Quorum sensing regulates dpsA and the oxidative stress response in Burkholderia pseudomallei . Microbiology vol. 152 , ( 12 ) 3651 - 3659 .
Uroz S, Oger P, Chhabra SR, Cámara M, Williams P, Dessaux Y ( 2006 ) . N-acyl homoserine lactones are degraded via an amidolytic activity in Comamonas sp. strain D1 . Archives of Microbiology vol. 187 , ( 3 ) 249 - 256 .
Throup JP, Camara M, Briggs GS, Winson MK, Chhabra SR, Bycroft BW, Williams P, Stewart GSAB ( 2006 ) . Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two N‐acylhomoserine lactone signal molecules . Molecular Microbiology vol. 17 , ( 2 ) 345 - 356 .
Latifi A, Winson MK, Foglino M, Bycroft BW, Stewart GSAB, Lazdunski A, Williams P ( 2006 ) . Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1 . Molecular Microbiology vol. 17 , ( 2 ) 333 - 343 .
Salmond GPC, Bycroft BW, Stewart GSAB, Williams P ( 2006 ) . The bacterial ‘enigma’: cracking the code of cell–cell communication . Molecular Microbiology vol. 16 , ( 4 ) 615 - 624 .
Eberl L, Winson MK, Sternberg C, Stewart GSAB, Christiansen G, Chhabra SR, Bycroft B, Williams P et al. ( 2006 ) . Involvement of N‐acyl‐l‐homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens . Molecular Microbiology vol. 20 , ( 1 ) 127 - 136 .
Ortori CA, Atkinson S, Chhabra SR, Cámara M, Williams P, Barrett DA ( 2006 ) . Comprehensive profiling of N-acylhomoserine lactones produced by Yersinia pseudotuberculosis using liquid chromatography coupled to hybrid quadrupole–linear ion trap mass spectrometry . Analytical and Bioanalytical Chemistry vol. 387 , ( 2 ) 497 - 511 .
Wei J-R, Soo P-C, Horng Y-T, Hsieh S-C, Tsai Y-H, Swift S, Withers H, Williams P et al. ( 2006 ) . Regulatory roles of spnT, a novel gene located within transposon TnTIR . Biochemical and Biophysical Research Communications vol. 348 , ( 3 ) 1038 - 1046 .
Diggle SP, Lumjiaktase P, Dipilato F, Winzer K, Kunakorn M, Barrett DA, Chhabra SR, Cámara M et al. ( 2006 ) . Functional Genetic Analysis Reveals a 2-Alkyl-4-Quinolone Signaling System in the Human Pathogen Burkholderia pseudomallei and Related Bacteria . Cell Chemical Biology vol. 13 , ( 7 ) 701 - 710 .
Ryan RP, Fouhy Y, Lucey JF, Crossman LC, Spiro S, He Y-W, Zhang L-H, Heeb S et al. ( 2006 ) . Cell–cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover . Proceedings of the National Academy of Sciences of the United States of America vol. 103 , ( 17 ) 6712 - 6717 .
Doherty N, Holden MTG, Qazi SN, Williams P, Winzer K ( 2006 ) . Functional Analysis of luxS in Staphylococcus aureus Reveals a Role in Metabolism but Not Quorum Sensing . Journal of Bacteriology vol. 188 , ( 8 ) 2885 - 2897 .
Williams P, Ciurana B, Camprubi S, Tomas JM ( 2006 ) . Influence of lipopolysaccharide chemotype on the interaction between Klebsiella pneumoniae and human polymorphonuclear leucocytes . FEMS Microbiology Letters vol. 69 , ( 3 ) 305 - 309 .
Holland J, Towner KJ, Williams P ( 2006 ) . Isolation and characterisation of Haemophilus influenzae type b mutants defective in transferrin‐binding and iron assimilation . FEMS Microbiology Letters vol. 77 , ( 2‐3 ) 283 - 288 .
Williams P, Bainton NJ, Swift S, Chhabra SR, Winson MK, Stewart GSAB, Salmond GPC, Bycroft BW ( 2006 ) . Small molecule‐mediated density‐dependent control of gene expression in prokaryotes: Bioluminescence and the biosynthesis of carbapenem antibiotics . FEMS Microbiology Letters vol. 100 , ( 1‐3 ) 161 - 167 .
Morton DJ, Williams P ( 2006 ) . Utilization of transferrin‐bound iron by Haemophilus species of human and porcine origins . FEMS Microbiology Letters vol. 65 , ( 1‐2 ) 123 - 127 .
Scott RA, Weil J, Le PT, Williams P, Fray RG, von Bodman SB, Savka MA ( 2006 ) . Long- and short-chain plant-produced bacterial N-acyl-homoserine lactones become components of phyllosphere, rhizosphere, and soil . Molecular Plant-Microbe Interactions vol. 19 , ( 3 ) 227 - 239 .
Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Cámara M et al. ( 2006 ) . Quorum Quenching by an N-Acyl-Homoserine Lactone Acylase from Pseudomonas aeruginosa PAO1 . Infection and Immunity vol. 74 , ( 3 ) 1673 - 1682 .
Williams P ( 2006 ) . Quorum sensing . International Journal of Medical Microbiology vol. 296 , ( 2-3 ) 57 - 59 .
Diggle SP, Cornelis P, Williams P, Cámara M ( 2006 ) . 4-Quinolone signalling in Pseudomonas aeruginosa: Old molecules, new perspectives . International Journal of Medical Microbiology vol. 296 , ( 2-3 ) 83 - 91 .
Diggle SP, Stacey RE, Dodd C, Cámara M, Williams P, Winzer K ( 2006 ) . The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa . Environmental Microbiology vol. 8 , ( 6 ) 1095 - 1104 .
Wei J-R, Tsai Y-H, Horng Y-T, Soo P-C, Hsieh S-C, Hsueh P-R, Horng J-T, Williams P et al. ( 2006 ) . A Mobile Quorum-Sensing System in Serratia marcescens . Journal of Bacteriology vol. 188 , ( 4 ) 1518 - 1525 .
Atkinson S, Chang C-Y, Sockett RE, Cámara M, Williams P ( 2006 ) . Quorum Sensing in Yersinia enterocolitica Controls Swimming and Swarming Motility . Journal of Bacteriology vol. 188 , ( 4 ) 1451 - 1461 .
Qazi S, Middleton B, Muharram SH, Cockayne A, Hill P, O'Shea P, Chhabra SR, Cámara M et al. ( 2006 ) . N-Acylhomoserine Lactones Antagonize Virulence Gene Expression and Quorum Sensing in Staphylococcus aureus . Infection and Immunity vol. 74 , ( 2 ) 910 - 919 .
Evans‐Hurrell JA, Adler J, Denyer S, Rogers TG, Williams P ( 2006 ) . A method for the enumeration of bacterial adhesion to epithelial cells using image analysis . FEMS Microbiology Letters vol. 107 , ( 1 ) 77 - 82 .
Griffiths E, Stevenson P, Byfield P, Ala'Aldeen DA, Borriello SP, Holland J, Parsons T, Williams P ( 2006 ) . Antigenic relationships of transferrin‐binding proteins from Neisseria meningitisis, N. gonorrhoeae and Haemophilus influenzae: Cross‐reactivity of antibodies to NH2‐terminal peptides . FEMS Microbiology Letters vol. 109 , ( 1 ) 85 - 91 .
Winson MK, Swift S, Fish L, Throup JP, Jørgensen F, Chhabra SR, Bycroft BW, Williams P et al. ( 2006 ) . Construction and analysis of luxCDABE‐based plasmid sensors for investigating N‐acyl homoserine lactone‐mediated quorum sensing . FEMS Microbiology Letters vol. 163 , ( 2 ) 185 - 192 .
Fukushima J, Ishiwata T, You Z, Ishii T, Shigematsu T, Kurata M, Chikumaru‐Fujita S, Bycroft BW et al. ( 2006 ) . Dissection of the promoter/operator region and evaluation of N‐acylhomoserine lactone mediated transcriptional regulation of elastase expression in Pseudomonas aeruginosa . FEMS Microbiology Letters vol. 146 , ( 2 ) 311 - 318 .
Winson MK, Swift S, Hill PJ, Sims CM, Griesmayr G, Bycroft BW, Williams P, Stewart GSAB ( 2006 ) . Engineering the luxCDABE genes from Photorhabdus luminescens to provide a bioluminescent reporter for constitutive and promoter probe plasmids and mini‐Tn5 constructs . FEMS Microbiology Letters vol. 163 , ( 2 ) 193 - 202 .
You Z, Fukushima J, Ishiwata T, Chang B, Kurata M, Kawamoto S, Williams P, Okuda K ( 2006 ) . Purification and characterization of LasR as a DNA‐binding protein . FEMS Microbiology Letters vol. 142 , ( 2‐3 ) 301 - 307 .
Middleton B, Rodgers HC, Cámara M, Knox AJ, Williams P, Hardman A ( 2006 ) . Direct detection of N‐acylhomoserine lactones in cystic fibrosis sputum . FEMS Microbiology Letters vol. 207 , ( 1 ) 1 - 7 .
Fitchen N, Williams P, Hardie KR ( 2006 ) . Functional complementation of E. coli secD and secG mutants by Helicobacter pylori homologues . FEMS Microbiology Letters vol. 229 , ( 1 ) 57 - 63 .
Kirke DF, Swift S, Lynch MJ, Williams P ( 2006 ) . The Aeromonas hydrophila LuxR homologue AhyR regulates the N‐acyl homoserine lactone synthase, AhyI positively and negatively in a growth phase‐dependent manner . FEMS Microbiology Letters vol. 241 , ( 1 ) 109 - 117 .
Atkinson S, Sockett RE, Cámara M, Williams P ( 2006 ) . Quorum sensing and the lifestyle of Yersinia . Current Issues in Molecular Biology vol. 8 , ( 1 ) 1 - 10 .
Heeb S, Kuehne SA, Bycroft M, Crivii S, Allen MD, Haas D, Cámara M, Williams P ( 2005 ) . Functional Analysis of the Post-transcriptional Regulator RsmA Reveals a Novel RNA-binding Site . Journal of Molecular Biology vol. 355 , ( 5 ) 1026 - 1036 .
Pritchard DI, Todd I, Brown A, Bycroft BW, Chhabra SR, Williams P, Wood P ( 2005 ) . Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone . Acta Diabetologica vol. 42 , ( 3 ) 119 - 122 .
Uroz S, Chhabra SR, Cámara M, Williams P, Oger P, Dessaux Y ( 2005 ) . N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities . Microbiology vol. 151 , ( 10 ) 3313 - 3322 .
Fitchen N, Letley DP, O'Shea P, Atherton JC, Williams P, Hardie KR ( 2005 ) . All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretion . Journal of Medical Microbiology vol. 54 , ( 7 ) 621 - 630 .
Lai H-C, Soo P-C, Wei J-R, Yi W-C, Liaw S-J, Horng Y-T, Lin S-M, Ho S-W et al. ( 2005 ) . The RssAB Two-Component Signal Transduction System in Serratia marcescens Regulates Swarming Motility and Cell Envelope Architecture in Response to Exogenous Saturated Fatty Acids . Journal of Bacteriology vol. 187 , ( 10 ) 3407 - 3414 .
Aendekerk S, Diggle SP, Song Z, Høiby N, Cornelis P, Williams P, Cámara M ( 2005 ) . The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication . Microbiology vol. 151 , ( 4 ) 1113 - 1125 .
Williams P ( 2005 ) . Quorum sensing: an emerging target for antibacterial chemotherapy? . Expert Opinion on Therapeutic Targets vol. 6 , ( 3 ) 257 - 274 .
Ferrándiz M-J, Bishop K, Williams P, Withers H ( 2005 ) . HosA, a Member of the SlyA Family, Regulates Motility in Enteropathogenic Escherichia coli . Infection and Immunity vol. 73 , ( 3 ) 1684 - 1694 .
Carter GP, Purdy D, Williams P, Minton NP ( 2005 ) . Quorum sensing in Clostridium difficile: analysis of a luxS-type signalling system . Journal of Medical Microbiology . vol. 54 , 119 - 127 .
Delalande L, Faure D, Raffoux A, Uroz S, D'Angelo‐Picard C, Elasri M, Carlier A, Berruyer R et al. ( 2004 ) . N‐hexanoyl‐l‐homoserine lactone, a mediator of bacterial quorum‐sensing regulation, exhibits plant‐dependent stability and may be inactivated by germinating Lotus corniculatus seedlings . FEMS Microbiology Ecology vol. 52 , ( 1 ) 13 - 20 .
Tait K, Joint I, Daykin M, Milton DL, Williams P, Cámara M ( 2004 ) . Disruption of quorum sensing in seawater abolishes attraction of zoospores of the green alga Ulva to bacterial biofilms . Environmental Microbiology vol. 7 , ( 2 ) 229 - 240 .
Koerber AJ, King JR, Williams P ( 2004 ) . Deterministic and stochastic modelling of endosome escape by Staphylococcus aureus: “quorum” sensing by a single bacterium . Journal of Mathematical Biology vol. 50 , ( 4 ) 440 - 488 .
Anguige K, King JR, Ward JP, Williams P ( 2004 ) . Mathematical modelling of therapies targeted at bacterial quorum sensing . Mathematical Biosciences vol. 192 , ( 1 ) 39 - 83 .
Westfall LW, Luna AM, Francisco MS, Diggle SP, Worrall KE, Williams P, Cámara M, Hamood AN ( 2004 ) . The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression . Microbiology vol. 150 , ( 11 ) 3797 - 3806 .
Hooi DSW, Bycroft BW, Chhabra SR, Williams P, Pritchard DI ( 2004 ) . Differential Immune Modulatory Activity of Pseudomonas aeruginosa Quorum-Sensing Signal Molecules . Infection and Immunity vol. 72 , ( 11 ) 6463 - 6470 .
Norman ME, Williams P, Illum L ( 2004 ) . In vivo evaluation of protein adsorption to sterically stabilised colloidal carriers . Journal of Biomedical Materials Research vol. 27 , ( 7 ) 861 - 866 .
Ward JP, King JR, Koerber AJ, Croft JM, Sockett RE, Williams P ( 2004 ) . Cell‐signalling repression in bacterial quorum sensing . Mathematical Medicine and Biology A Journal of the IMA vol. 21 , ( 3 ) 169 - 204 .
Toth IK, Newton JA, Hyman LJ, Lees AK, Daykin M, Ortori C, Williams P, Fray RG ( 2004 ) . Potato plants genetically modified to produce N-acylhomoserine lactones increase susceptibility to soft rot erwiniae . Molecular Plant-Microbe Interactions vol. 17 , ( 8 ) 880 - 887 .
Chan WC, Coyle BJ, Williams P ( 2004 ) . Virulence Regulation and Quorum Sensing in Staphylococcal Infections: Competitive AgrC Antagonists as Quorum Sensing Inhibitors § . Journal of Medicinal Chemistry vol. 47 , ( 19 ) 4633 - 4641 .
Croxatto A, Pride J, Hardman A, Williams P, Cámara M, Milton DL ( 2004 ) . A distinctive dual‐channel quorum‐sensing system operates in Vibrio anguillarum . Molecular Microbiology vol. 52 , ( 6 ) 1677 - 1689 .
Vallet I, Diggle SP, Stacey RE, Cámara M, Ventre I, Lory S, Lazdunski A, Williams P et al. ( 2004 ) . Biofilm Formation in Pseudomonas aeruginosa: Fimbrial cup Gene Clusters Are Controlled by the Transcriptional Regulator MvaT† . Journal of Bacteriology vol. 186 , ( 9 ) 2880 - 2890 .
Qazi SNA, Harrison SE, Self T, Williams P, Hill PJ ( 2004 ) . Real-Time Monitoring of Intracellular Staphylococcus aureus Replication . Journal of Bacteriology vol. 186 , ( 4 ) 1065 - 1077 .
Morrissey JA, Cockayne A, Brummell K, Williams P ( 2004 ) . The Staphylococcal Ferritins Are Differentially Regulated in Response to Iron and Manganese and via PerR and Fur . Infection and Immunity vol. 72 , ( 2 ) 972 - 979 .
Barnard FM, Loughlin MF, Fainberg HP, Messenger MP, Ussery DW, Williams P, Jenks PJ ( 2003 ) . Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori . Molecular Microbiology vol. 51 , ( 1 ) 15 - 32 .
Fitchen N, O’Shea P, Williams P, Hardie KR ( 2003 ) . Electrostatic sensor for identifying interactions between peptides and bacterial membranes . Molecular Immunology vol. 40 , ( 7 ) 407 - 411 .
Barber CE, Tang JL, Feng JX, Pan MQ, Wilson TJG, Slater H, Dow JM, Williams P et al. ( 2003 ) . A novel regulatory system required for pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule . Molecular Microbiology vol. 24 , ( 3 ) 555 - 566 .
McGowan SJ, Sebaihia M, O'Leary S, Hardie KR, Williams P, Stewart GSAB, Bycroft BW, Salmond GPC ( 2003 ) . Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel β‐lactam resistance mechanism . Molecular Microbiology vol. 26 , ( 3 ) 545 - 556 .
Chapon‐Hervé V, Akrim M, Latifi A, Williams P, Lazdunski A, Bally M ( 2003 ) . Regulation of the xcp secretion pathway by multiple quorum‐sensing modulons in Pseudomonas aeruginosa . Molecular Microbiology vol. 24 , ( 6 ) 1169 - 1178 .
Thomson NR, Cox A, Bycroft BW, Stewart GSAB, Williams P, Salmond GPC ( 2003 ) . The Rap and Hor proteins of Erwinia, Serratia and Yersinia: a novel subgroup in a growing superfamily of proteins regulating diverse physiological processes in bacterial pathogens . Molecular Microbiology vol. 26 , ( 3 ) 531 - 544 .
Winzer K, Williams P ( 2003 ) . Escherichia coli gets the message . Nature Medicine vol. 9 , ( 9 ) 1118 - 1119 .
King JR, Koerber AJ, Croft JM, Ward JP, Williams P, Sockett RE ( 2003 ) . Modelling host tissue degradation by extracellular bacterial pathogens . Mathematical Medicine and Biology A Journal of the IMA vol. 20 , ( 3 ) 227 - 260 .
Diggle SP, Winzer K, Chhabra SR, Worrall KE, Cámara M, Williams P ( 2003 ) . The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density‐dependency of the quorum sensing hierarchy, regulates rhl‐dependent genes at the onset of stationary phase and can be produced in the absence of LasR . Molecular Microbiology vol. 50 , ( 1 ) 29 - 43 .
Scott RJ, Lian L-Y, Muharram SH, Cockayne A, Wood SJ, Bycroft BW, Williams P, Chan WC ( 2003 ) . Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system . Bioorganic & Medicinal Chemistry Letters vol. 13 , ( 15 ) 2449 - 2453 .
Ward JP, King JR, Koerber AJ, Croft JM, Sockett RE, Williams P ( 2003 ) . Early development and quorum sensing in bacterial biofilms . Journal of Mathematical Biology vol. 47 , ( 1 ) 23 - 55 .
Ward C, Cámara M, Forrest I, Rutherford R, Pritchard G, Daykin M, Hardman A, de Soyza A et al. ( 2003 ) . Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients . Thorax vol. 58 , ( 5 )
Winzer K, Hardie KR, Williams P ( 2003 ) . LuxS and Autoinducer-2: Their Contribution to Quorum Sensing and Metabolism in Bacteria . vol. 53 , 291 - 396 .
Chhabra SR, Harty C, Hooi DSW, Daykin M, Williams P, Telford G, Pritchard DI, Bycroft BW ( 2002 ) . Synthetic Analogues of the Bacterial Signal (Quorum Sensing) Molecule N-(3-Oxododecanoyl)-l-homoserine Lactone as Immune Modulators . Journal of Medicinal Chemistry vol. 46 , ( 1 ) 97 - 104 .
Joint I, Tait K, Callow ME, Callow JA, Milton D, Williams P, Cámara M ( 2002 ) . Cell-to-Cell Communication Across the Prokaryote-Eukaryote Boundary . Science vol. 298 , ( 5596 ) 1207 - 1207 .
Cámara M, Williams P, Hardman A ( 2002 ) . Controlling infection by tuning in and turning down the volume of bacterial small-talk . The Lancet Infectious Diseases vol. 2 , ( 11 ) 667 - 676 .
Burton CL, Chhabra SR, Swift S, Baldwin TJ, Withers H, Hill SJ, Williams P ( 2002 ) . The Growth Response of Escherichia coli to Neurotransmitters and Related Catecholamine Drugs Requires a Functional Enterobactin Biosynthesis and Uptake System . Infection and Immunity vol. 70 , ( 11 ) 5913 - 5923 .
Yates EA, Philipp B, Buckley C, Atkinson S, Chhabra SR, Sockett RE, Goldner M, Dessaux Y et al. ( 2002 ) . N-Acylhomoserine Lactones Undergo Lactonolysis in a pH-, Temperature-, and Acyl Chain Length-Dependent Manner during Growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa . Infection and Immunity vol. 70 , ( 10 ) 5635 - 5646 .
Cámara M, Hardman A, Williams P, Milton D ( 2002 ) . Quorum sensing in Vibrio cholerae . Nature Genetics vol. 32 , ( 2 ) 217 - 218 .
Horng Y, Deng S, Daykin M, Soo P, Wei J, Luh K, Ho S, Swift S et al. ( 2002 ) . The LuxR family protein SpnR functions as a negative regulator of N‐acylhomoserine lactone‐dependent quorum sensing in Serratia marcescens . Molecular Microbiology vol. 45 , ( 6 ) 1655 - 1671 .
Taminiau B, Daykin M, Swift S, Boschiroli M-L, Tibor A, Lestrate P, De Bolle X, O'Callaghan D et al. ( 2002 ) . Identification of a Quorum-Sensing Signal Molecule in the Facultative Intracellular Pathogen Brucella melitensis . Infection and Immunity vol. 70 , ( 6 ) 3004 - 3011 .
Diggle SP, Winzer K, Lazdunski A, Williams P, Cámara M ( 2002 ) . Advancing the Quorum in Pseudomonas aeruginosa: MvaT and the Regulation of N-Acylhomoserine Lactone Production and Virulence Gene Expression† . Journal of Bacteriology vol. 184 , ( 10 ) 2576 - 2586 .
Morrissey JA, Cockayne A, Hammacott J, Bishop K, Denman-Johnson A, Hill PJ, Williams P ( 2002 ) . Conservation, Surface Exposure, and In Vivo Expression of the Frp Family of Iron-Regulated Cell Wall Proteins in Staphylococcus aureus . Infection and Immunity vol. 70 , ( 5 ) 2399 - 2407 .
Jiang Y, Camara M, Chhabra SR, Hardie KR, Bycroft BW, Lazdunski A, Salmond GPC, Stewart GSAB et al. ( 2002 ) . In vitro biosynthesis of the Pseudomonas aeruginosa quorum‐sensing signal molecule N‐butanoyl‐L‐homoserine lactone . Molecular Microbiology vol. 28 , ( 1 ) 193 - 203 .
Winzer K, Hardie KR, Williams P ( 2002 ) . Bacterial cell-to-cell communication: sorry, can't talk now — gone to lunch! . Current Opinion in Microbiology vol. 5 , ( 2 ) 216 - 222 .
Winzer K, Hardie KR, Burgess N, Doherty N, Kirke D, Holden MTG, Linforth R, Cornell KA et al. ( 2002 ) . LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone . Microbiology vol. 148 , ( 4 ) 909 - 922 .
Croxatto A, Chalker VJ, Lauritz J, Jass J, Hardman A, Williams P, Cámara M, Milton DL ( 2002 ) . VanT, a Homologue of Vibrio harveyi LuxR, Regulates Serine, Metalloprotease, Pigment, and Biofilm Production in Vibrio anguillarum . Journal of Bacteriology vol. 184 , ( 6 ) 1617 - 1629 .
Atkinson S, Throup JP, Stewart GSAB, Williams P ( 2002 ) . A hierarchical quorum‐sensing system in Yersinia pseudotuberculosis is involved in the regulation of motility and clumping . Molecular Microbiology vol. 33 , ( 6 ) 1267 - 1277 .
Koerber AJ, King JR, Ward JP, Williams P, Croft JM, Sockett RE ( 2002 ) . A mathematical model of partial-thickness burn-wound infection by Pseudomonas aeruginosa: Quorum sensing and the build-up to invasion . Bulletin of Mathematical Biology vol. 64 , ( 2 ) 239 - 259 .
CURTIS MA, Aduse-Opoku A, Camara M, Kirke D, Burgess N, Williams P, Winzer K, Meyers N et al. ( 2002 ) . LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence . Microbiology vol. 148 , 763 - 772 .
Williams P ( 2002 ) . Obituary for Professor Gordon S. A. B. Stewart . Molecular Microbiology vol. 32 , ( 3 ) 447 - 448 .
Holden MTG, Chhabra SR, De Nys R, Stead P, Bainton NJ, Hill PJ, Manefield M, Kumar N et al. ( 2002 ) . Quorum‐sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram‐negative bacteria . Molecular Microbiology vol. 33 , ( 6 ) 1254 - 1266 .
Lithgow JK, Wilkinson A, Hardman A, Rodelas B, Wisniewski‐Dyé F, Williams P, Downie JA ( 2002 ) . The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum‐sensing loci . Molecular Microbiology vol. 37 , ( 1 ) 81 - 97 .
MDowell P, Affas Z, Reynolds C, Holden MTG, Wood SJ, Saint S, Cockayne A, Hill PJ et al. ( 2001 ) . Structure, activity and evolution of the group I thiolactone peptide quorum‐sensing system of Staphylococcus aureus . Molecular Microbiology vol. 41 , ( 2 ) 503 - 512 .
Qazi SNA, Counil E, Morrissey J, Rees CED, Cockayne A, Winzer K, Chan WC, Williams P et al. ( 2001 ) . agr Expression Precedes Escape of InternalizedStaphylococcus aureus from the Host Endosome . Infection and Immunity vol. 69 , ( 11 ) 7074 - 7082 .
Ward JP, King JR, Koerber AJ, Williams P, Croft JM, Sockett RE ( 2001 ) . Mathematical modelling of quorum sensing in bacteria . Mathematical Medicine and Biology A Journal of the IMA vol. 18 , ( 3 ) 263 - 292 .
Milton DL, Chalker VJ, Kirke D, Hardman A, Cámara M, Williams P ( 2001 ) . The LuxM Homologue VanM from Vibrio anguillarumDirects the Synthesis of N-(3-Hydroxyhexanoyl)homoserine Lactone and N-Hexanoylhomoserine Lactone . Journal of Bacteriology vol. 183 , ( 12 ) 3537 - 3547 .
Withers H, Swift S, Williams P ( 2001 ) . Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria . Current Opinion in Microbiology vol. 4 , ( 2 ) 186 - 193 .
Winzer K, Williams P ( 2001 ) . Quorum sensing and the regulation of virulence gene expression in pathogenic bacteria . International Journal of Medical Microbiology vol. 291 , ( 2 ) 131 - 143 .
Swift S, Downie JA, Whitehead NA, Barnard AML, Salmond GPC, Williams P ( 2001 ) . Quorum sensing as a population-density-dependent determinant of bacterial physiology . vol. 45 , Elsevier
Gotschlich A, Huber B, Geisenberger O, Tögl A, Steidle A, Riedel K, Hill P, Tümmler B et al. ( 2001 ) . Synthesis of Multiple N-Acylhomoserine Lactones is Wide-spread Among the Members of the Burkholderia cepacia Complex . Systematic and Applied Microbiology vol. 24 , ( 1 ) 1 - 14 .
Winzer K, Falconer C, Garber NC, Diggle SP, Camara M, Williams P ( 2000 ) . The Pseudomonas aeruginosa Lectins PA-IL and PA-IIL Are Controlled by Quorum Sensing and by RpoS . Journal of Bacteriology vol. 182 , ( 22 ) 6401 - 6411 .
Morrissey JA, Cockayne A, Hill PJ, Williams P ( 2000 ) . Molecular Cloning and Analysis of a Putative Siderophore ABC Transporter from Staphylococcus aureus . Infection and Immunity vol. 68 , ( 11 ) 6281 - 6288 .
Laue BE, Jiang Y, Chhabra SR, Jacob S, Stewart GSAB, Hardman A, Downie JA, O'Gara F et al. ( 2000 ) . The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl)homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase . Microbiology vol. 146 , ( 10 ) 2469 - 2480 .
Williams P, Camara M, Hardman A, Swift S, Milton D, Hope VJ, Winzer K, Middleton B et al. ( 2000 ) . Quorum sensing and the population-dependent control of virulence . Philosophical Transactions of the Royal Society B Biological Sciences vol. 355 , ( 1397 ) 667 - 680 .
Modun B, Morrissey J, Williams P, Modun B, Morrissey J, Williams P ( 2000 ) . The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions . Trends in Microbiology vol. 8 , ( 5 ) 231 - 237 .
Fray RG, Throup JP, Daykin M, Wallace A, Williams P, Stewart GSAB, Grierson D ( 1999 ) . Plants genetically modified to produce N-acylhomoserine lactones communicate with bacteria . Nature Biotechnology vol. 17 , ( 10 ) 1017 - 1020 .
Swift S, Lynch MJ, Fish L, Kirke DF, Tomás JM, Stewart GSAB, Williams P ( 1999 ) . Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila . Infection and Immunity vol. 67 , ( 10 ) 5192 - 5199 .
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA ( 1999 ) . Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae . Journal of Bacteriology vol. 181 , ( 12 ) 3816 - 3823 .
Jørgensen F, Bally M, Chapon-Herve V, Michel G, Lazdunski A, Williams P, Stewart GSAB ( 1999 ) . RpoS-dependent stress tolerance in Pseudomonas aeruginosa . Microbiology vol. 145 , ( 4 ) 835 - 844 .
Modun B, Williams P ( 1999 ) . The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase . Infection and Immunity vol. 67 , ( 3 ) 1086 - 1092 .
Hardman AM, Stewart GSAB, Williams P ( 1998 ) . Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria . Antonie van Leeuwenhoek vol. 74 , ( 4 ) 199 - 210 .
Finch RG, Pritchard DI, Bycroft BW, Williams P, Stewart GS ( 1998 ) . Quorum sensing: a novel target for anti-infective therapy . Journal of Antimicrobial Chemotherapy vol. 42 , ( 5 ) 569 - 571 .
Chernin LS, Winson MK, Thompson JM, Haran S, Bycroft BW, Chet I, Williams P, Stewart GSAB ( 1998 ) . Chitinolytic activity in Chromobacterium violaceum: substrate analysis and regulation by quorum sensing . Journal of Bacteriology vol. 180 , ( 17 ) 4435 - 4441 .
Hill PJ, Cockayne A, Landers P, Morrissey JA, Sims CM, Williams P ( 1998 ) . SirR, a novel iron-dependent repressor in Staphylococcus epidermidis . Infection and Immunity vol. 66 , ( 9 ) 4123 - 4129 .
Cockayne A, Hill PJ, Powell NBL, Bishop K, Sims C, Williams P ( 1998 ) . Molecular cloning of a 32-kilodalton lipoprotein component of a novel iron-regulated Staphylococcus epidermidis ABC transporter . Infection and Immunity vol. 66 , ( 8 ) 3767 - 3774 .
Modun B, Evans RW, Joannou CL, Williams P ( 1998 ) . Receptor-mediated recognition and uptake of iron from human transferrin by Staphylococcus aureus and Staphylococcus epidermidis . Infection and Immunity vol. 66 , ( 8 ) 3591 - 3596 .
Holden MTG, McGowan SJ, Bycroft BW, Stewart GSAB, Williams P, Salmond GPC ( 1998 ) . Cryptic carbapenem antibiotic production genes are widespread in Erwinia carotovora: facile trans activation by the carR transcriptional regulator . Microbiology vol. 144 , ( 6 ) 1495 - 1508 .
Modun BJ, Cockayne A, Finch R, Williams P ( 1998 ) . The Staphylococcus aureus and Staphylococcus epidermidis transferrin-binding proteins are expressed in vivo during infection . Microbiology vol. 144 , ( 4 ) 1005 - 1012 .
Cox ARJ, Thomson NR, Bycroft B, Stewart GSAB, Williams P, Salmond GPC ( 1998 ) . A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens . Microbiology vol. 144 , ( 1 ) 201 - 209 .
Telford G, Wheeler D, Williams P, Tomkins PT, Appleby P, Sewell H, Stewart GSAB, Bycroft BW et al. ( 1998 ) . The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity . Infection and Immunity vol. 66 , ( 1 ) 36 - 42 .
Wood DW, Gong F, Daykin MM, Williams P, Pierson LS ( 1997 ) . N-acyl-homoserine lactone-mediated regulation of phenazine gene expression by Pseudomonas aureofaciens 30-84 in the wheat rhizosphere . Journal of Bacteriology vol. 179 , ( 24 ) 7663 - 7670 .
McClean KH, Winson MK, Fish L, Taylor A, Chhabra SR, Camara M, Daykin M, Lamb JH et al. ( 1997 ) . Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones . Microbiology vol. 143 , ( 12 ) 3703 - 3711 .
Swift S, Karlyshev AV, Fish L, Durant EL, Winson MK, Chhabra SR, Williams P, Macintyre S et al. ( 1997 ) . Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules . Journal of Bacteriology vol. 179 , ( 17 ) 5271 - 5281 .
Batchelor SE, Cooper M, Chhabra SR, Glover LA, Stewart GS, Williams P, Prosser JI ( 1997 ) . Cell density-regulated recovery of starved biofilm populations of ammonia-oxidizing bacteria . Applied and Environmental Microbiology vol. 63 , ( 6 ) 2281 - 2286 .
HASAN A, HOLLAND J, SMITH A, WILLIAMS P ( 1997 ) . Elemental iron does repress transferrin, haemopexin and haemoglobin receptor expression in . FEMS Microbiology Letters vol. 150 , ( 1 ) 19 - 26 .
Milton DL, Hardman A, Camara M, Chhabra SR, Bycroft BW, Stewart GS, Williams P ( 1997 ) . Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone . Journal of Bacteriology vol. 179 , ( 9 ) 3004 - 3012 .
Holland J, Parsons TR, Hasan AA, Cook SM, Stevenson P, Griffiths E, Williams P ( 1996 ) . Conservation and antigenic cross-reactivity of the transferrin-binding proteins of Haemophilus influenzae, Actinobacillus pleuropneumoniae and Neisseria meningitidis . Microbiology vol. 142 , ( 12 ) 3505 - 3513 .
Swift S, Stewart GSAB, Williams P ( 1996 ) . The inner workings of a quorum sensing signal generator . Trends in Microbiology vol. 4 , ( 12 ) 463 - 465 .
McGowan SJ, Sebaihia M, Porter LE, Stewart GS, Williams P, Bycroft BW, Salmond GP ( 1996 ) . Analysis of bacterial carbapenem antibiotic production genes reveals a novel beta-lactam biosynthesis pathway . Molecular Microbiology vol. 22 , ( 3 ) 415 - 426 .
Swift S, Throup JP, Williams P, Salmond GP, Stewart GS ( 1996 ) . Quorum sensing: a population-density component in the determination of bacterial phenotype . Trends in Biochemical Sciences vol. 21 , ( 6 ) 214 - 219 .
Wong JC, Patel R, Kendall D, Whitby PW, Smith A, Holland J, Williams P ( 1995 ) . Affinity, conservation, and surface exposure of hemopexin-binding proteins in Haemophilus influenzae . Infection and Immunity vol. 63 , ( 6 ) 2327 - 2333 .
Williams P, Swift S, Modun B ( 1995 ) . Continuous ambulatory peritoneal dialysis-associated peritonitis as a model device-related infection: phenotypic adaptation, the staphylococcal cell envelope and infection . Journal of Hospital Infection . vol. 30 , 35 - 43 .
McGowan S, Sebaihia M, Jones S, Yu B, Bainton N, Chan PF, Bycroft B, Stewart GSAB et al. ( 1995 ) . Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator . Microbiology vol. 141 , ( 5 ) 1268 - 1268 .
McGowan S, Sebaihia M, Jones S, Yu B, Bainton N, Chan PF, Bycroft B, Stewart GS et al. ( 1995 ) . Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator . Microbiology vol. 141 , ( 3 ) 541 - 550 .
CHAN PF, BAINTON NJ, DAYKIN MM, WINSON MK, CHHABRA SR, STEWART GSAB, SALMOND GPC, BYCROFT BW et al. ( 1995 ) . Small molecule mediated autoinduction of antibiotic biosynthesis in the plant pathogen Erwinia carotovora . Biochemical Society Transactions . vol. 23 , 127s - 127s .
Modun B, Kendall D, Williams P ( 1994 ) . Staphylococci express a receptor for human transferrin: identification of a 42-kilodalton cell wall transferrin-binding protein . Infection and Immunity vol. 62 , ( 9 ) 3850 - 3858 .
Wong JC, Holland J, Parsons T, Smith A, Williams P ( 1994 ) . Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b . Infection and Immunity vol. 62 , ( 1 ) 48 - 59 .
CHHABRA SR, STEAD P, BAINTON NJ, SALMOND GPC, STEWART GSAB, WILLIAMS P, BYCROFT BW ( 1993 ) . AUTOREGULATION OF CARBAPENEM BIOSYNTHESIS IN Erwinia carotovora BY ANALOGUES OF N-(3-OXOHEXANOYL)-L-HOMOSERINE LACTONE . The Journal of Antibiotics vol. 46 , ( 3 ) 441 - 454 .
Norman ME, Williams P, Illum L ( 1993 ) . Influence of block copolymers on the adsorption of plasma proteins to microspheres . Biomaterials vol. 14 , ( 3 ) 193 - 202 .
Bainton NJ, Stead P, Chhabra SR, Bycroft BW, Salmond GPC, Stewart GSAB, Williams P ( 1992 ) . N-(3-oxohexanoyl)-l-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora . Biochemical Journal vol. 288 , ( 3 ) 997 - 1004 .
Williams P, Griffiths E ( 1992 ) . Bacterial transferrin receptors — structure, function and contribution to virulence . Medical Microbiology and Immunology vol. 181 , ( 6 ) 301 - 322 .
Camprubi S, Smith MA, Tomas JM, Williams P ( 1992 ) . Modulation of surface antigen expression by Klebsiella pneumoniae in response to growth environment . Microbial Pathogenesis vol. 13 , ( 2 ) 145 - 155 .
Holland J, Langford PR, Towner KJ, Williams P ( 1992 ) . Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b . Infection and Immunity vol. 60 , ( 7 ) 2986 - 2991 .
Stewart GS, Williams P ( 1992 ) . lux genes and the applications of bacterial bioluminescence . Microbiology vol. 138 , ( 7 ) 1289 - 1300 .
Modun B, Williams P, Pike WJ, Cockayne A, Arbuthnott JP, Finch R, Denyer SP ( 1992 ) . Cell envelope proteins of Staphylococcus epidermidis grown in vivo in a peritoneal chamber implant . Infection and Immunity vol. 60 , ( 6 ) 2551 - 2553 .
Stevenson P, Williams P, Griffiths E ( 1992 ) . Common antigenic domains in transferrin-binding protein 2 of Neisseria meningitidis, Neisseria gonorrhoeae, and Haemophilus influenzae type b . Infection and Immunity vol. 60 , ( 6 ) 2391 - 2396 .
Holland J, Towner KJ, Williams P ( 1992 ) . Tn916 insertion mutagenesis in Escherichia coli and Haemophilus influenzae type b following conjugative transfer . Microbiology vol. 138 , ( 3 ) 509 - 515 .
Norman ME, Williams P, Illum L ( 1992 ) . Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres . Biomaterials vol. 13 , ( 12 ) 841 - 849 .
Wilcox MH, Williams P, Smith DG, Modun B, Finch RG, Denyer SP ( 1991 ) . Variation in the expression of cell envelope proteins of coagulase-negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate . Microbiology vol. 137 , ( 11 ) 2561 - 2570 .
Gledhill L, Williams P, Bycroft BW ( 1991 ) . Irreversible inactivation of β-lactamase I from Bacillus cereus by chlorinated 6-spiroepoxypenicillins . Biochemical Journal vol. 276 , ( 3 ) 801 - 807 .
O'Hagan DT, Rahman D, McGee JP, Jeffery H, Davies MC, Williams P, Davis SS, Challacombe SJ ( 1991 ) . Biodegradable microparticles as controlled release antigen delivery systems . Immunology vol. 73 , ( 2 ) 239 - 242 .
Tomás JM, Camprubi S, Merino S, Davey MR, Williams P ( 1991 ) . Surface exposure of O1 serotype lipopolysaccharide in Klebsiella pneumoniae strains expressing different K antigens . Infection and Immunity vol. 59 , ( 6 ) 2006 - 2011 .
Wilcox MH, Finch RG, Smith DGE, Williams P, Denyer SP ( 1991 ) . Effects of carbon dioxide and sub-lethal levels of antibiotics on adherence of coagulase-negativestaphylococci to polystyrene and silicone rubber . Journal of Antimicrobial Chemotherapy vol. 27 , ( 5 ) 577 - 587 .
Smith DG, Wilcox MH, Williams P, Finch RG, Denyer SP ( 1991 ) . Characterization of cell envelope proteins of Staphylococcus epidermidis cultured in human peritoneal dialysate . Infection and Immunity vol. 59 , ( 2 ) 617 - 624 .
Williams P, Morton DJ, Towner KJ, Stevenson P, Griffiths E ( 1990 ) . Utilization of enterobactin and other exogenous iron sources by Haemophilus influenzae, H. parainfluenzae and H. paraphrophilus . Microbiology vol. 136 , ( 12 ) 2343 - 2350 .
Wilcox MH, Smith DG, Evans JA, Denyer SP, Finch RG, Williams P ( 1990 ) . Influence of carbon dioxide on growth and antibiotic susceptibility of coagulase-negative staphylococci cultured in human peritoneal dialysate . Journal of Clinical Microbiology vol. 28 , ( 10 ) 2183 - 2186 .
Denyer SP, Davies MC, Evans JA, Finch RG, Smith DG, Wilcox MH, Williams P ( 1990 ) . Influence of carbon dioxide on the surface characteristics and adherence potential of coagulase-negative staphylococci . Journal of Clinical Microbiology vol. 28 , ( 8 ) 1813 - 1817 .
Morton DJ, Williams P ( 1990 ) . Siderophore-independent acquisition of transferrin-bound iron by Haemophilus influenzae type b . Microbiology vol. 136 , ( 5 ) 927 - 933 .
Williams P, Smith MA, Stevenson P, Griffiths E, Tomas JM ( 1989 ) . Novel Aerobactin Receptor in Klebsiella pneumoniae . Microbiology vol. 135 , ( 12 ) 3173 - 3181 .
Bycroft BW, Lockey PM, Penrose A, Grout RJ, Williams P ( 1989 ) . Antibacterial and immunostimulatory properties of chemotactic N-formyl peptide conjugates of ampicillin and amoxicillin . Antimicrobial Agents and Chemotherapy vol. 33 , ( 9 ) 1516 - 1521 .
Figgitt DP, Denyer SP, Dewick PM, Jackson DE, Williams P ( 1989 ) . Topoisomerase II: A potential target for novel antifungal agents . Biochemical and Biophysical Research Communications vol. 160 , ( 1 ) 257 - 262 .
Morton DJ, Williams P ( 1989 ) . Characterization of the Outer-membrane Proteins of Haemophilus parainfluenzae Expressed under Iron-sufficient and Iron-restricted Conditions . Microbiology vol. 135 , ( 2 ) 445 - 451 .
Williams P ( 1988 ) . Role of the cell envelope in bacterial adaptation to growth in vivo in infections . Biochimie vol. 70 , ( 8 ) 987 - 1011 .
Tomas JM, Camprubi S, Williams P ( 1988 ) . Surface exposure of the O-antigen in Klebsiella pneumoniae O1:K1 serotype strains . Microbial Pathogenesis vol. 5 , ( 2 ) 141 - 147 .
Williams P, Lambert PA, Brown MR ( 1988 ) . Penetration of immunoglobulins through the Klebsiella capsule and their effect on cell-surface hydrophobicity . Journal of Medical Microbiology vol. 26 , ( 1 ) 29 - 35 .
Williams P ( 1987 ) . Sub-MICs of cefuroxime and ciprofloxacin influence interaction of complement and immunoglobulins with Klebsiella pneumoniae . Antimicrobial Agents and Chemotherapy vol. 31 , ( 5 ) 758 - 762 .
Williams P, Lambert PA, Haigh CG, Brown MR ( 1986 ) . The influence of the O and K antigens of Klebsiella aerogenes on surface hydrophobicity and susceptibility to phagocytosis and antimicrobial agents . Journal of Medical Microbiology vol. 21 , ( 2 ) 125 - 132 .
Lodge JM, Williams P, Brown MR ( 1986 ) . Influence of growth rate and iron limitation on the expression of outer membrane proteins and enterobactin by Klebsiella pneumoniae grown in continuous culture . Journal of Bacteriology vol. 165 , ( 2 ) 353 - 356 .
Brown MR, Williams P ( 1985 ) . The Influence of Environment on Envelope Properties Affecting Survival of Bacteria in Infections . Annual Review of Microbiology vol. 39 , ( 1 ) 527 - 556 .
Brown MRW, Williams P ( 1985 ) . Influence of substrate limitation and growth phase on sensitivity to antimicrobial agents . Journal of Antimicrobial Chemotherapy vol. 15 , ( suppl_A ) 7 - 14 .
WILLIAMS P, BROWN MRW, LAMBERT PA ( 1984 ) . Effect of Iron Deprivation on the Production of Siderophores and Outer Membrane Proteins in Klebsiella aerogenes . Microbiology vol. 130 , ( 9 ) 2357 - 2365 .
Williams P, Lambert PA, Brown MRW, Jones RJ ( 1983 ) . The Role of the O and K Antigens in Determining the Resistance of Klebsiella aerogenes to Serum Killing and Phagocytosis . Microbiology vol. 129 , ( 7 ) 2181 - 2191 .