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Publications:  Dr Juan Gaston Massuet

Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al.(2020). Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin. The FASEB Journal
10.1096/fj.202000312R
Mariniello K, Ruiz-Babot G, McGaugh EC, Nicholson JG, Gualtieri A, Gaston-Massuet C, Nostro MC, Guasti L(2019). Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System. Frontiers in Endocrinology vol. 10,
10.3389/fendo.2019.00772
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64750
Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR et al.(2019). Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox. Circulation Research vol. 125, (9) 847-854.
10.1161/CIRCRESAHA.119.314927
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61089
Ewans LJ, Colley A, Gaston-Massuet C, Gualtieri A, Cowley MJ, McCabe MJ, Anand D, Lachke SA et al.(2019). Pathogenic variants in PLOD3 result in a Stickler syndrome-like connective tissue disorder with vascular complications. Journal of Medical Genetics vol. 56, (9) 629-638.
10.1136/jmedgenet-2019-106019
Barry S, Carlsen E, Marques P, Stiles CE, Gadaleta E, Berney DM, Roncaroli F, Chelala C et al.(2019). Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors. Oncogene vol. 38, (27) 5381-5395.
10.1038/s41388-019-0779-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57414
Macdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M et al.(2019). Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice. Diabetes vol. 68, (7) 1473-1484.
10.2337/db18-1243
Gregory LC, Ferreira CB, Young-Baird SK, Williams HJ, Harakalova M, van Haaften G, Rahman SA, Gaston-Massuet C et al.(2019). Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation. EBioMedicine vol. 42, 470-480.
10.1016/j.ebiom.2019.03.013
Macdougall C, Wood E, Charalambous M, Gaston-Massuet C, Taketo MM, Marelli-Berg F, Longhi MP (2018). Investigating beta-catenin signalling in conventional dendritic cells in obesity-induced tissue inflammation. EUROPEAN JOURNAL OF IMMUNOLOGY. vol. 48, 18-19.
Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L et al.(2018). Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metabolism vol. 27, (3) 588-601.e4.
10.1016/j.cmet.2018.02.007
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36587
Bettini LR, Graziola F, Fazio G, Grazioli P, Scagliotti V, Pasquini M, Cazzaniga G, Biondi A et al.(2018). Rings and bricks: Expression of cohesin components is dynamic during development and adult life. International Journal of Molecular Sciences vol. 19, (2)
10.3390/ijms19020438
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59379
Jimenez FA, Gualtieri A, Scagliotti V, Gaston-Massuet C (2017). Ephrin-B2 is critical regulator of endocrine organ development. MECHANISMS OF DEVELOPMENT. vol. 145, S161-S161.
10.1016/j.mod.2017.04.460
Crescente M, Armstrong PC, CHAN MV, Edin ML, Lih FB, Jiao J, Gaston-Massuet C, Cottrell GS et al. (2017). PLATELET COX-1 KNOCKOUT MOUSE AS A MODEL OF THE EFFECTS OF ASPIRIN IN THE CARDIOVASCULAR SYSTEM. HEART. Conference: BCS Annual Conference, ‘Cardiology at the Extremes' vol. 103, A108-A109.
10.1136/heartjnl-2017-311726.146
Giri D, Vignola ML, Gualtieri A, Scagliotti V, Didi M, Gaston-Massuet C, Senniappan S (2017). A NOVEL DENOVO FORKHEAD BOX A2 (FOXA2) MUTATION LEADS TO CONGENITAL HYPERINSULINISM, CRANIOFACIAL DYSMORPHIC FEATURES AND CONGENITAL HYPOPITUITARISM. HORMONE RESEARCH IN PAEDIATRICS. vol. 88, 43-43.
Rolas L, Barkaway A, Morrell S, Golding M, Gaston-Massuet C, Lopez-Otin C, Nourshargh S (2017). Characterization of a Novel Mouse Model of Endothelial Cell Progerin Expression. JOURNAL OF VASCULAR RESEARCH. vol. 54, 7-7.
Gregory LC, Mccabe MJ, Alatzoglou KS, Turton JP, Webb EA, Williams H, Gaston-Massuet C, Kelberman D et al. (2017). IDENTIFICATION OF GENETIC VARIANTS IN A LARGE COHORT OF PATIENTS WITH CONGENITAL HYPOTHALAMO-PITUITARY DISORDERS. HORMONE RESEARCH IN PAEDIATRICS. vol. 88, 42-42.
Giri D, Vignola ML, Gualtieri A, Scagliotti V, McNamara P, Peak M, Didi M, Gaston-Massuet C et al.(2017). Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endodermderived organ abnormalities. Human Molecular Genetics vol. 26, (22) 4315-4326.
10.1093/hmg/ddx318
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61680
Fazio G, Gaston-Massuet C, Bettini LR, Graziola F, Scagliotti V, Cereda A, Ferrari L, Mazzola M et al.(2016). CyclinD1 Down-Regulation and Increased Apoptosis Are Common Features of Cohesinopathies. Journal of Cellular Physiology vol. 231, (3) 613-622.
10.1002/jcp.25106
Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S et al.(2016). Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Proceedings of the National Academy of Sciences of the United States of America vol. 113, (5) E548-E557.
10.1073/pnas.1503346113
Avagliano L, Doi P, Tosi D, Scagliotti V, Gualtieri A, Gaston-Massuet C, Pistocchi A, Gallina A et al.(2016). Cell death and cell proliferation in human spina bifida. Birth Defects Research Part A - Clinical and Molecular Teratology vol. 106, (2) 104-113.
10.1002/bdra.23466
Scagliotti V, Avagliano L, Gualtieri A, Graziola F, Doi P, Chalker J, Righini A, Korbonits M et al.(2016). Histopathology and molecular characterisation of intrauterine-diagnosed congenital craniopharyngioma. Pituitary vol. 19, (1) 50-56.
10.1007/s11102-015-0682-1
Gregory LC, Williams H, Rahman S, Ferreira CB, Alatzoglou KS, Kapoor RR, Hussain K, Gaston-Massuet C et al. (2016). A Novel Mutation in Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) is Associated with X-Linked Hypopituitarism and Glucose Dysregulation. HORMONE RESEARCH IN PAEDIATRICS. vol. 86, 35-35.
Gregory L, Kypranou N, Besser R, Vignola L, Temple K, Davis J, Gevers E, Dattani M et al. (2016). The MAPK Effector BRAF is Essential for the Integrity of Hypothalamic-Pituitary Development and Deregulation of this Pathway Causes Congenital Hypopituitarism. HORMONE RESEARCH IN PAEDIATRICS. vol. 86, 33-34.
McCabe MJ, Hu Y, Gregory LC, Gaston-Massuet C, Alatzoglou KS, Saldanha JW, Gualtieri A, Thankamony A et al.(2015). Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD). Molecular and Cellular Endocrinology vol. 417, 63-72.
10.1016/j.mce.2015.09.010
Gregory LC, Gaston-Massuet C, Andoniadou CL, Carreno G, Webb EA, Kelberman D, McCabe MJ, Panagiotakopoulos L et al.(2015). The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism. Clin Endocrinol (Oxf) vol. 82, (5) 728-738.
10.1111/cen.12637
Graziola F, Scagliotti V, Gold-Diaz D, Gaston-Massuet C, Massa V (2013). Nipbl expression analysis in the developing mouse embryo. GENETICS RESEARCH. vol. 95, 185-185.
Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P et al.(2013). Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential. Cell Stem Cell vol. 13, (4) 433-445.
10.1016/j.stem.2013.07.004
McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto K-H et al.(2013). Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia. J Clin Endocrinol Metab vol. 98, (3) E547-E557.
10.1210/jc.2012-3067
Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH et al.(2012). SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest vol. 122, (10) 3635-3646.
10.1172/JCI64311
Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH et al.(2012). Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol vol. 124, (2) 259-271.
10.1007/s00401-012-0957-9
Jayakody SA, Andoniadou C, Signore M, Gaston-Massuet C, Pevny LH, Brue T, Martinez-Barbera J-P (2011). Investigating genetic factors underlying hypopituitarism and septo-optic dysplasia in humans. GENETICS RESEARCH. vol. 93, 437-438.
Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP(2011). HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain. Development vol. 138, (22) 4931-4942.
10.1242/dev.066597
McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D et al.(2011). Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction. J Clin Endocrinol Metab vol. 96, (10) E1709-E1718.
10.1210/jc.2011-0454
GASTON MASSUET JC, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS et al.(2011). Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A. vol. 108, (28) 11482-11487.
10.1073/pnas.1101553108
Sottocornola R, Royer C, Vives V, Tordella L, Zhong S, Wang Y, Ratnayaka I, Shipman M et al.(2010). ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS Development. DEVELOPMENTAL CELL vol. 19, (1) 126-137.
10.1016/j.devcel.2010.06.003
Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody S, Charolidi N, Le Tissier P, Dattani M, Martinez-Barbera JP (2010). Enhancement of the Canonical Wnt Pathway in Rathke's Pouch Results in Pituitary Tumours Reminiscent of Human Adamantinomatous Craniopharyngioma. ENDOCRINE REVIEWS. vol. 31, S2523-S2523.
Gaston-Massuet C, Kelberman D, Dattani M, Martinez-Barbera JP(2009). Absence of SIX3 mutations in patients with congenital hypopituitarism. Am J Med Genet A vol. 149A, (12) 2874-2876.
10.1002/ajmg.a.33103
Andoniadou CL, Gaston-Massuet C, Martinez-Barbera JP (2009). Hesx1 antagonises canonical Wnt signalling in anterior forebrain and pituitary gland. MECHANISMS OF DEVELOPMENT. vol. 126, S229-S230.
10.1016/j.mod.2009.06.588
Jayakody SA, Gaston-Massuet C, Andoniadou CL, Dattani M, Matinez-Barbera JP (2009). Molecular analysis of Hesx1 function in pituitary and hypothalamic development. MECHANISMS OF DEVELOPMENT. vol. 126, S135-S135.
10.1016/j.mod.2009.06.280
Massa V, Ybot-Gonzalez P, Savery D, Gaston-Massuet C, Greene NE, Copp AJ(2009). Role of Zic2 in mammalian neural tube closure. GENETICS RESEARCH vol. 91, (2) 140-140.
Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JMA, Martinez-Barbera JP(2008). Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol vol. 324, (2) 322-333.
10.1016/j.ydbio.2008.08.008
Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D et al.(2008). Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech vol. 1, (4-5) 241-254.
10.1242/dmm.000711
Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M, Martinez-Barbera JP(2008). DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim Biophys Acta vol. 1783, (1) 131-143.
10.1016/j.bbamcr.2007.08.010
Ybot-Gonzalez P, Gaston-Massuet C, Girdler G, Klingensmith J, Arkell R, Greene NDE, Copp AJ(2007). Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. Development vol. 134, (17) 3203-3211.
10.1242/dev.008177
Andoniadou C, Signore M, Sajedi E, Gaston-Massuet C, Barbera JPM (2007). Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. GENETICS RESEARCH. vol. 89, 182-182.
Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M et al.(2007). Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development vol. 134, (8) 1499-1508.
10.1242/dev.02829
Sajed E, Gaston-Massuet C, Signore M, Dattani M, Martinez-Barbera JP (2006). Role of the homeobox gene Hesx1/HESX1 in forebrain and pituitary formation in mouse and humans. GENETICAL RESEARCH. vol. 88, 72-73.
Gaston-Massuet C, Henderson DJ, Greene NDE, Copp AJ(2005). Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system. Dev Dyn vol. 233, (3) 1110-1115.
10.1002/dvdy.20417
Gaston-Massuet C, Elms P, Henderson D, Arkell R, Copp A (2003). Requirement for Zic2 during mouse neurulation. DEVELOPMENTAL BIOLOGY. vol. 259, 529-529.
Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P et al.(2003). Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet vol. 12, (2) 87-98.
10.1093/hmg/ddg014
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