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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Maria Longhi

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Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S et al. ( 2024 ) . Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation . Nature Cardiovascular Research vol. 3 , ( 9 ) 1067 - 1082 .
Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al. ( 2023 ) . The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing . Nature Metabolism
Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al. ( 2022 ) . Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity . Circulation vol. 146 , ( 25 ) 1930 - 1945 .
Vyas V, Blythe H, Wood EG, Sandhar B, Sarker S-J, Balmforth D, Ambekar SG, Yap J et al. ( 2021 ) . Obesity and diabetes are major risk factors for epicardial adipose tissue inflammation . JCI Insight vol. 6 , ( 16 )
Hearnden R, Sandhar B, Vyas V, Longhi MP ( 2021 ) . Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applications . STAR Protocols vol. 2 , ( 2 )
Bajaj R, Sinclair HC, Patel K, Low B, Pericao A, Manisty C, Guttmann O, Zemrak F et al. ( 2021 ) . Delayed-onset myocarditis following COVID-19 . The Lancet Respiratory Medicine vol. 9 , ( 4 ) e32 - e34 .
Wood EG, Macdougall CE, Blythe H, Clément M, Colas RA, Dalli J, Marelli-Berg F, Longhi MP ( 2020 ) . HIF1α activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipids . Scientific Reports vol. 10 , ( 1 )
Vyas V, Hunter RJ, Longhi MP, Finlay MC ( 2020 ) . Inflammation and adiposity: new frontiers in atrial fibrillation . EP Europace vol. 22 , ( 11 ) 1609 - 1618 .
Macdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M et al. ( 2019 ) . Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice . Diabetes vol. 68 , ( 7 ) 1473 - 1484 .
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al. ( 2019 ) . Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)) . Cell vol. 178 , ( 1 ) 263 - 263 .
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al. ( 2019 ) . Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR . Cell vol. 177 , ( 5 ) 1201 - 1216.e19 .
Macdougall CE, Longhi MP ( 2019 ) . Adipose tissue dendritic cells in steady‐state . Immunology vol. 156 , ( 3 ) 228 - 234 .
Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P et al. ( 2018 ) . Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation . Nature Communications vol. 9 , ( 1 )
Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L et al. ( 2018 ) . Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets . Cell Metabolism vol. 27 , ( 3 ) 588 - 601.e4 .
CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al. ( 2017 ) . Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma . PLoS Medicine
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2017 ) . Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Med vol. 14 , ( 7 )
MAURO C, Smith J, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Cermenati G et al. ( 2017 ) . Obesity-induced metabolic stress leads to biased effector memory CD4+ T cell differentiation via PI3K p110δ/Akt-mediated signals . Cell Metabolism
Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL et al. ( 2016 ) . The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells . Immunity vol. 45 , ( 6 ) 1205 - 1218 .
Rajan SS, Longhi MP ( 2016 ) . Dendritic cells and adipose tissue . Immunology vol. 149 , ( 4 ) 353 - 361 .
Anandasabapathy N, Feder R, Mollah S, Tse S-W, Longhi MP, Mehandru S, Matos I, Cheong C et al. ( 2014 ) . Classical Flt3L-dependent dendritic cells control immunity to protein vaccine . Journal of Experimental Medicine vol. 211 , ( 9 ) 1875 - 1891 .
Pantel A, Teixeira A, Haddad E, Wood EG, Steinman RM, Longhi MP ( 2014 ) . Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation . PLOS Biology vol. 12 , ( 1 )
Barbuto S, Idoyaga J, Vila-Perelló M, Longhi MP, Breton G, Steinman RM, Muir TW ( 2013 ) . Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells . Nature Chemical Biology vol. 9 , ( 4 ) 250 - 256 .
Trumpfheller C, Longhi MP, Caskey M, Idoyaga J, Bozzacco L, Keler T, Schlesinger SJ, Steinman RM ( 2012 ) . Dendritic cell‐targeted protein vaccines: a novel approach to induce T‐cell immunity . Journal of Internal Medicine vol. 271 , ( 2 ) 183 - 192 .
Pantel A, Cheong C, Dandamudi D, Shrestha E, Mehandru S, Brane L, Ruane D, Teixeira A et al. ( 2011 ) . A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T‐cell immunity in vivo . European Journal of Immunology vol. 42 , ( 1 ) 101 - 109 .
Cheong C, Matos I, Choi J-H, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM et al. ( 2010 ) . Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas . Cell vol. 143 , ( 3 ) 416 - 429 .
Bozzacco L, Trumpfheller C, Huang Y, Longhi MP, Shimeliovich I, Schauer JD, Park CG, Steinman RM ( 2009 ) . HIV gag protein is efficiently cross‐presented when targeted with an antibody towards the DEC‐205 receptor in Flt3 ligand‐mobilized murine DC . European Journal of Immunology vol. 40 , ( 1 ) 36 - 46 .
Sivasankar B, Longhi MP, Gallagher KME, Betts GJ, Morgan BP, Godkin AJ, Gallimore AM ( 2009 ) . CD59 Blockade Enhances Antigen-Specific CD4+ T Cell Responses in Humans: A New Target for Cancer Immunotherapy? . The Journal of Immunology vol. 182 , ( 9 ) 5203 - 5207 .
LONGHI PM, Trumpfheller C, Idoyaga J, Caskey M, Matos I, Kluger C, Salazar AM, Colonna M et al. ( 2009 ) . Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant . J EXP MED vol. 206 , ( 7 ) 1589 - 1602 .
Longhi MP, Wright K, Lauder SN, Nowell MA, Jones GW, Godkin AJ, Jones SA, Gallimore AM ( 2008 ) . Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells . PLOS Pathogens vol. 4 , ( 2 )
Trumpfheller C, Caskey M, Nchinda G, Longhi MP, Mizenina O, Huang Y, Schlesinger SJ, Colonna M et al. ( 2008 ) . The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine . Proceedings of the National Academy of Sciences of the United States of America vol. 105 , ( 7 ) 2574 - 2579 .
Richards H, Longhi MP, Wright K, Gallimore A, Ager A ( 2008 ) . CD62L (L-Selectin) Down-Regulation Does Not Affect Memory T Cell Distribution but Failure to Shed Compromises Anti-Viral Immunity . The Journal of Immunology vol. 180 , ( 1 ) 198 - 206 .
Longhi MP, Williams A, Wise M, Morgan BP, Gallimore A ( 2007 ) . CD59a deficiency exacerbates influenza‐induced lung inflammation through complement‐dependent and ‐independent mechanisms . European Journal of Immunology vol. 37 , ( 5 ) 1266 - 1274 .
Sivasankar B, Donev RM, Longhi MP, Hughes TR, Davies R, Cole DS, Morgan BP, Marchbank KJ ( 2007 ) . CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens . Molecular Immunology vol. 44 , ( 11 ) 2978 - 2987 .
Omidvar N, Wang ECY, Brennan P, Longhi MP, Smith RAG, Morgan BP ( 2006 ) . Expression of Glycosylphosphatidylinositol-Anchored CD59 on Target Cells Enhances Human NK Cell-Mediated Cytotoxicity . The Journal of Immunology vol. 176 , ( 5 ) 2915 - 2923 .
Longhi MP, Harris CL, Morgan BP, Gallimore A ( 2006 ) . Holding T cells in check – a new role for complement regulators? . Trends in Immunology vol. 27 , ( 2 ) 102 - 108 .
Longhi MP, Sivasankar B, Omidvar N, Morgan BP, Gallimore A ( 2005 ) . Cutting Edge: Murine CD59a Modulates Antiviral CD4+ T Cell Activity in a Complement-Independent Manner . The Journal of Immunology vol. 175 , ( 11 ) 7098 - 7102 .
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM ( 2005 ) . Complement: central to innate immunity and bridging to adaptive responses . Immunology Letters . vol. 97 , 171 - 179 .
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