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Publications:  Dr Jordi Lopez Tremoleda

Nandi M, Jackson SK, Macrae D, Shankar-Hari M, Tremoleda JL, Lilley E(2020). Rethinking animal models of sepsis - working towards improved clinical translation whilst integrating the 3Rs. Clin Sci (Lond) vol. 134, (13) 1715-1734.
10.1042/CS20200679
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C et al.(2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers in Immunology vol. 11,
10.3389/fimmu.2020.00010
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63161
Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV et al.(2020). A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice. Journal of Neurotrauma vol. 37, (1) 66-79.
10.1089/neu.2019.6420
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59204
Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C, Brohi K(2019). Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity. Frontiers in Immunology vol. 10,
10.3389/fimmu.2019.02774
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63503
Zuchman OT, Svendsen L, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT (2019). A NEW KETOGENIC FORMULATION IMPROVES FUNCTIONAL OUTCOME AND REDUCES TISSUE DAMAGE FOLLOWING TRAUMATIC BRAIN INJURY. JOURNAL OF NEUROTRAUMA. vol. 36, A131-A132.
Yip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW, Michael-Titus AT et al.(2019). Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system. Journal of Neuroscience Methods vol. 321, 49-63.
10.1016/j.jneumeth.2019.04.005
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57716
Thau-Zuchman O, Gomes RN, Dyall SC, Davies M, Priestley JV, Groenendijk M, De Wilde MC, Tremoleda JL et al.(2019). Brain Phospholipid Precursors Administered Post-Injury Reduce Tissue Damage and Improve Neurological Outcome in Experimental Traumatic Brain Injury. Journal of Neurotrauma vol. 36, (1) 25-42.
10.1089/neu.2017.5579
https://qmro.qmul.ac.uk/xmlui/handle/123456789/45403
Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Cole JE, Goddard M, Cheung MSH, Bhakoo KK et al.(2018). Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging. Journal of Vascular Surgery vol. 67, (5) 1571-1583.e3.
10.1016/j.jvs.2017.04.046
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25087
Tremoleda JL, Macholl S, Sosabowski JK(2018). Anesthesia and monitoring of animals during MRI studies. vol. 1718, 423-439.
10.1007/978-1-4939-7531-0_25
Alvarez K, Lopez-Tremoleda J, Donnan R, Michael-Titus AT, Tomlins PH (2018). Heart rate sensitive optical coherence angiography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 10493,
10.1117/12.2317602
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39729
Lopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS, MICHAEL-TITUS AT, TOMLINS PH(2017). Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice. Journal of Biomedical Optics vol. 22, (12) 121710-121710.
10.1117/1.JBO.22.12.121710
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29107
Venero JL, Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Tr AMSEZ-HLAJSJL et al. (2017). Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury. GLIA. Conference: XIII European Glial Meeting vol. 65, E504-E504.
Tremoleda JL, Watts SA, Reynolds PS, Thiemermann C, Brohi K(2017). Modelling Acute Traumatic Haemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies. Shock
10.1097/SHK.0000000000000901
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23172
Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J et al.(2017). Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PLoS One vol. 12, (2) e0172776-e0172776.
10.1371/journal.pone.0172776
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22263
Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H et al.(2017). Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Scientific Reports vol. 7, Article 41689, 41689-41689.
10.1038/srep41689
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22239
Pedrigi RM, Mehta V, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L et al.(2016). Influence of shear stress magnitude and direction on atherosclerotic plaque composition. Royal Society Open Science vol. 3, (10)
10.1098/rsos.160588
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17883
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J et al.(2016). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid. Eur J Nucl Med Mol Imaging vol. 43, (9) 1710-1722.
10.1007/s00259-016-3391-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12308
Luong L, Duckles H, Schenkel T, Mahmoud MM, Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP et al.(2016). Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. Thrombosis and Haemostasis vol. 116, (1) 181-190.
10.1160/TH16-03-0214
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13776
LOPEZ TREMOLEDA J(2016). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid. Eur J Nucl Med Mol Imaging
10.1007/s00259-016-3391-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17886
Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT(2016). A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury. BRAIN INJURY vol. 30, (5-6) 679-679.
Wall JM, Tremoleda JL, Thiemermann C, Brohi K (2015). HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE. SHOCK. vol. 44, 21-22.
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al. (2015). IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. SHOCK. vol. 44, 24-25.
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al.(2015). T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. Shock vol. 44 Suppl 2, 24-25.
10.1097/01.shk.0000472079.77136.27
Tremoleda JL, Sosabowski J(2015). Imaging technologies and basic considerations for welfare of laboratory rodents. LAB ANIMAL vol. 44, (3) 101-109.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/8256
Tremoleda JL, Sosabowski J(2015). Imaging technologies and basic considerations for welfare of laboratory rodents. Lab Animal vol. 44, (3) 97-105.
10.1038/laban.665
Guerreiro M, Tremoleda JL, Frith D, Thiemermann C, Brohi K(2014). Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 22, (1)
10.1186/1757-7241-22-S1-O6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6986
Guerreiro ML, Tremoleda JL, Thiemermann C, Brohi K (2014). REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY. SHOCK. vol. 41, 51-51.
Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Gibbs RGJ(2014). Imaging of the vulnerable carotid plaque: biological targeting of inflammation in atherosclerosis using iron oxide particles and MRI. Eur J Vasc Endovasc Surg vol. 47, (5) 462-469.
10.1016/j.ejvs.2014.01.017
Cuhlmann S, Gsell W, Van Der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al.(2014). In vivo mapping of vascular inflammation using the translocator protein tracer <sup>18</sup>F-FEDAA1106. Molecular Imaging vol. 13, (6)
10.2310/7290.2014.00014
Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Gsell W, Reneman L (2013). Amphetamine pretreatment alters the response to a methylphenidate challenge: a pharmacological magnetic resonance imaging study. EUROPEAN NEUROPSYCHOPHARMACOLOGY. vol. 23, S272-S272.
10.1016/S0924-977X(13)70424-3
Lopez-Tremoleda J, Gsell W(2013). The use of contrast agents to enhance soft-tissue imaging using micro-CT in laboratory rodents. Animal Technology and Welfare vol. 12, (1) 59-62.
Stasiuk GJ, Smith H, Wylezinska-Arridge M, Tremoleda JL, Trigg W, Luthra SK, Morisson Iveson V, Gavins FNE et al.(2013). Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation. Chem Commun (Camb) vol. 49, (6) 564-566.
10.1039/c2cc37460a
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al.(2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A vol. 110, (3) 832-841.
10.1073/pnas.1209362110
Tremoleda JL, Khan NS, Mann V, Racey SN, Martin AJ, Simpson AHWR, Noble BS(2012). Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation. J Musculoskelet Neuronal Interact vol. 12, (4) 241-253.
Van Doormaal MA, Kazakidi A, Wylezinska M, Hunt A, Tremoleda JL, Protti A, Bohraus Y, Gsell W et al.(2012). Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic root. J R Soc Interface vol. 9, (76) 2834-2844.
10.1098/rsif.2012.0295
Tremoleda JL, Kerton A, Gsell W(2012). Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare. EJNMMI Res vol. 2, (1)
10.1186/2191-219X-2-44
Seyfried F, Lannoo M, Gsell W, Tremoleda JL, Bueter M, Olbers T, Jurowich C, Germer C-T et al.(2012). Roux-en-Y gastric bypass in mice--surgical technique and characterisation. Obes Surg vol. 22, (7) 1117-1125.
10.1007/s11695-012-0661-9
Bouet V, Klomp A, Freret T, Wylezinska-Arridge M, Lopez-Tremoleda J, Dauphin F, Boulouard M, Booij J et al.(2012). Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment. Psychopharmacology (Berl) vol. 221, (2) 329-339.
10.1007/s00213-011-2580-1
Stuckey DJ, Tremoleda JL, Mcsweeney S, Fiedler L, Harada M, Carr CA, Tyler DJ, Gsell W et al. (2012). Systematic evaluation of 2D versus M-mode echocardiography in mice, compared to ex vivo and in vivo MRI. CARDIOVASCULAR RESEARCH. vol. 93, S90-S90.
Klomp A, Tremoleda JL, Wylezinska M, Nederveen AJ, Feenstra M, Gsell W, Reneman L(2012). Lasting effects of chronic fluoxetine treatment on the late developing rat brain: age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI. Neuroimage vol. 59, (1) 218-226.
10.1016/j.neuroimage.2011.07.082
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H et al.(2011). (18)FEDAA is a more specific probe than (18)FDG for imaging vascular inflammation. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38, S210-S210.
Tremoleda JL, Khalil M, Gsell W, Vincent T(2011). The use of micro-computed tomography to study bone changes in a preclinical model of Osteoarthritis. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38, S418-S418.
Song W, Dyer E, Stuckey DJ, Copeland O, Leung M-C, Bayliss C, Messer A, Wilkinson R et al.(2011). Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse. J Biol Chem vol. 286, (31) 27582-27593.
10.1074/jbc.M111.252320
Tremoleda JL, Khalil M, Gompels LL, Wylezinska-Arridge M, Vincent T, Gsell W(2011). Imaging technologies for preclinical models of bone and joint disorders. EJNMMI Res vol. 1, (1)
10.1186/2191-219X-1-11
Cuhlmann S, Van Der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA et al.(2011). Disturbed blood flow induces rela expression via c-Jun N-terminal kinase 1: A novel mode of NF-κB regulation that promotes arterial inflammation. Circulation Research vol. 108, (8) 950-959.
10.1161/CIRCRESAHA.110.233841
Kazakidi A, Wylezinska M, Bohraus Y, Van Doormaal M, Tremoleda JL, Gsell W, Weinberg PD, Ethier CR et al. (2010). NUMERICAL MODELLING OF BLOOD FLOW IN THE MOUSE AORTIC ARCH USING INFLOW VELOCITIES OBTAINED BY PHASE-CONTRAST MRI. PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010. 555-556.
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