Publications: Dr Angus Cameron
Zur Nedden S, Safari MS, Weber D, Kuenkel L, Garmsiri C, Lang L, Orset C, Freret T et al.
(
2024
)
.
Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models
.
Metabolism
vol.
161
,
Jalil SMA, Henry JC, Cameron AJM
(
2024
)
.
Targets in the Tumour Matrisome to Promote Cancer Therapy Response
.
Cancers
vol.
16
,
(
10
)
Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Dijke PT, Cameron AJ et al.
(
2023
)
.
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
.
The Journal of Pathology
vol.
262
,
(
1
)
90
-
104
.
Rulten SL, Grose RP, Gatz SA, Jones JL, Cameron AJM
(
2023
)
.
The Future of Precision Oncology
.
International Journal of Molecular Sciences
vol.
24
,
(
16
)
Okail MH, Kocher H, Cameron A
(
2023
)
.
Investigating the Role of Protein Kinase N2 (PKN2) in Pancreatic Ductal Adenocarcinoma
.
Pancreatology
vol.
23
,
(
4
)
Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Dijke PT, Cameron A et al.
(
2023
)
.
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
.
Pancreatology
vol.
23
,
(
4
)
e13
-
e14
.
Gibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A et al.
(
2023
)
.
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
.
npj Breast Cancer
vol.
9
,
(
1
)
Marshall JJT, Cull JJ, Alharbi HO, Thin MZ, Cooper STE, Barrington C, Vanyai H, Snoeks T et al.
(
2022
)
.
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses
.
Biochemical Journal
vol.
479
,
(
13
)
1467
-
1486
.
Menezes S, Okail MH, Jalil SMA, Kocher HM, Cameron AJM
(
2022
)
.
Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets
.
The Journal of Pathology
vol.
257
,
(
4
)
526
-
544
.
Colomba A, Claus J, Gao F, George R, Fornili A, Cameron AJM
(
2022
)
.
Targeting the HER3 pseudokinase domain with small molecule inhibitors
.
Methods in Enzymology
vol.
667
,
455
-
505
.
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
(
2022
)
.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
.
Cell Reports
vol.
38
,
(
4
)
Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A et al.
(
2019
)
.
Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration
.
Developmental Cell
vol.
51
,
(
4
)
460
-
475.e10
.
Hetmanski JHR, de Belly H, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C et al.
(
2019
)
.
Membrane tension orchestrates rear retraction in matrix directed cell migration
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
100
,
A44
-
A45
.
Zur Nedden S, Orset C, Haellewyn B, Freret T, Fresser F, Eith R, Cameron AJM, Parker PJ et al.
(
2018
)
.
ADORA2A-mediated protection of ischemia-reperfusion injury. Role of protein kinase N1: A new player in the pathophysiology of experimental stroke
.
PURINERGIC SIGNALLING
.
Conference:
PURINERGIC SIGNALLING
vol.
14
,
S50
-
S50
.
Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI et al.
(
2018
)
.
Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis
.
Immunity
vol.
48
,
(
6
)
1144
-
1159.e5
.
Claus J, Patel G, Autore F, Colomba A, Weitsman G, Soliman TN, Roberts S, Zanetti-Domingues LC et al.
(
2018
)
.
Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface
.
eLife
vol.
7
,
Nedden SZ, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJM et al.
(
2018
)
.
Protein kinase N1 critically regulates cerebellar development and longterm function
.
Journal of Clinical Investigation
vol.
128
,
(
5
)
2076
-
2088
.
Murray ER, Cameron AJM
(
2017
)
.
Towards specific inhibition of mTORC2
.
Aging
vol.
9
,
(
12
)
2461
-
2462
.
Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, Burghel GJ, Jain S et al.
(
2017
)
.
Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency
.
Cancer Cell
vol.
32
,
(
5
)
701
-
715.e7
.
Cameron AJM, Veeriah S, Marshall JJT, Murray ER, Larijani B, Parker PJ
(
2017
)
.
Uncoupling TORC2 from AGC kinases inhibits tumour growth
.
Oncotarget
vol.
5
,
(
0
)
84685
-
84696
.
Cenciarelli C, Marei HE, Felsani A, Casalbore P, Sica G, Puglisi MA, Cameron AJ, Olivi A et al.
(
2017
)
.
Correction: PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals
.
Oncotarget
vol.
8
,
(
22
)
36931
-
36931
.
Cenciarelli C, Marei HE, Felsani A, Casalbore P, Sica G, Puglisi MA, Cameron AJM, Olivi A et al.
(
2016
)
.
PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals
.
Oncotarget
Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, Burghel GJ, Jain S et al.
(
2016
)
.
Abstract LB-323: The genomic landscape of non-muscle-invasive bladder cancer: implications for molecular classification and treatment
.
Cancer Research
vol.
76
,
(
14_Supplement
)
Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT et al.
(
2016
)
.
Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion
.
Cell Reports
vol.
14
,
(
3
)
440
-
448
.
Martin-Liberal J, Cameron AJ, Claus J, Judson IR, Parker PJ, Linch M
(
2014
)
.
Targeting protein kinase C in sarcoma
.
Biochimica et Biophysica Acta - Reviews on Cancer
vol.
1846
,
(
2
)
547
-
559
.
Linch M, Riou P, Claus J, Cameron AJ, de Naurois J, Larijani B, Ng T, McDonald NQ et al.
(
2014
)
.
Functional implications of assigned, assumed and assembled PKC structures
.
Biochem Soc Trans
vol.
42
,
(
1
)
35
-
41
.
Linch M, Sanz-Garcia M, Rosse C, Riou P, Peel N, Madsen CD, Sahai E, Downward J et al.
(
2013
)
.
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids
.
Carcinogenesis
vol.
35
,
(
2
)
396
-
406
.
Linch M, Sanz-Garcia M, Soriano E, Zhang Y, Riou P, Rosse C, Cameron A, Knowles P et al.
(
2013
)
.
A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif
.
Science Signaling
vol.
6
,
(
293
)
Claus J, Cameron AJM, Parker PJ
(
2013
)
.
Pseudokinase drug intervention: a potentially poisoned chalice
.
Biochem Soc Trans
vol.
41
,
(
4
)
1083
-
1088
.
Cameron AJM, Linch MD, Saurin AT, Escribano C, Parker PJ
(
2011
)
.
mTORC2 targets AGC kinases through Sin1-dependent recruitment
.
Biochem J
vol.
439
,
(
2
)
287
-
297
.
Cameron AJM
(
2011
)
.
Occupational hazards: allosteric regulation of protein kinases through the nucleotide-binding pocket
.
Biochem Soc Trans
vol.
39
,
(
2
)
472
-
476
.
Rosse C, Linch M, Kermorgant S, Cameron AJM, Boeckeler K, Parker PJ
(
2010
)
.
PKC and the control of localized signal dynamics
.
Nat Rev Mol Cell Biol
vol.
11
,
(
2
)
103
-
112
.
Cameron AJM, Parker PJ
(
2010
)
.
Protein kinase C - a family of protein kinases, allosteric effectors or both?
.
Adv Enzyme Regul
vol.
50
,
(
1
)
169
-
177
.
Cameron AJM, Escribano C, Saurin AT, Kostelecky B, Parker PJ
(
2009
)
.
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity
.
Nat Struct Mol Biol
vol.
16
,
(
6
)
624
-
630
.
Cameron AJ, Procyk KJ, Leitges M, Parker PJ
(
2008
)
.
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival
.
Int J Cancer
vol.
123
,
(
4
)
769
-
779
.
Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ
(
2008
)
.
The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis
.
Nat Cell Biol
vol.
10
,
(
8
)
891
-
901
.
Durgan J, Cameron AJ, Saurin AT, Hanrahan S, Totty N, Messing RO, Parker PJ
(
2008
)
.
The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily
.
Biochem J
vol.
411
,
(
2
)
319
-
331
.
Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A et al.
(
2007
)
.
Protein kinases, from B to C
.
Biochem Soc Trans
vol.
35
,
(
Pt 5
)
1013
-
1017
.
Hillyard DZ, Nutt CD, Thomson J, McDonald KJ, Wan RK, Cameron AJM, Mark PB, Jardine AG
(
2007
)
.
Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylation
.
Atherosclerosis
vol.
191
,
(
2
)
319
-
325
.
Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A et al.
(
2007
)
.
Protein kinases, from B to C
.
Biochemical Society Transactions
vol.
35
,
(
5
)
1013
-
1017
.
Hillyard DZ, Cameron AJM, McDonald KJ, Thomson J, MacIntyre A, Shiels PG, Panarelli M, Jardine AG
(
2004
)
.
Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease
.
Atherosclerosis
vol.
175
,
(
2
)
305
-
313
.
Hillyard DZ, Jardine AG, McDonald KJ, Cameron AJM
(
2004
)
.
Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytes
.
Atherosclerosis
vol.
172
,
(
2
)
219
-
228
.
Cameron AJM, McDonald KJ, Harnett MM, Allen JM
(
2002
)
.
Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIb
.
Immunol Lett
vol.
83
,
(
3
)
171
-
179
.
Hillyard DZ, Cameron AJM, McIntyre AH, Hadden MH, Marshall HE, Johnston N, Jardine AG
(
2002
)
.
Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatin
.
Clin Exp Pharmacol Physiol
vol.
29
,
(
8
)
673
-
678
.
Hillyard D, Cameron A, MacIntyre A, Jardine A
(
2002
)
.
Mechanism of the Immunosuppressive Effects of Fluvastatin in Human Lymphocytes
.
Clinical Science
vol.
102
,
(
s46
)
8p
-
8p
.
McDonald KJ, Cameron AJM, Allen JM, Jardine AG
(
2002
)
.
Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy
.
Biochem Biophys Res Commun
vol.
290
,
(
1
)
438
-
442
.
McDonald KJ, Cameron AJM, Allen JM, McLay JS, Jardine AG
(
2002
)
.
A pathophysiological role for tubular Fc receptors in glomerulonephritis?
.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
vol.
13
,
175A
-
175A
.
Cameron AJ, Harnett MM, Allen JM
(
2001
)
.
Differential recruitment of accessory molecules by FcgammaRI during monocyte differentiation
.
Eur J Immunol
vol.
31
,
(
9
)
2718
-
2725
.
Cameron AJ, Allen JM
(
1999
)
.
The human high-affinity immunoglobulin G receptor activates SH2-containing inositol phosphatase (SHIP)
.
Immunology
vol.
97
,
(
4
)
641
-
647
.
CAMERON AJM, ALLEN JM
(
1999
)
.
The human high affinity IgG receptor (FcγRI) induces the association of the 5′Inositol phosphatase, SHIP, with She in U937 cells
.
Biochemical Society Transactions
vol.
27
,
(
3
)
a128
-
a128
.
Melendez A, Floto RA, Cameron AJ, Gillooly DJ, Harnett MM, Allen JM
(
1998
)
.
A molecular switch changes the signalling pathway used by the Fc gamma RI antibody receptor to mobilise calcium
.
Curr Biol
vol.
8
,
(
4
)
210
-
221
.
Cameron AJ, Allen JM
(
1997
)
.
Differential expression of the human high affinity IgG receptor Fc gamma RI and associated signalling molecules in differentiated U937 monocyte cells
.
Biochem Soc Trans
vol.
25
,
(
3
)
Leng J, Cameron AJ, Buckel S, Kennelly PJ
(
1995
)
.
Isolation and cloning of a protein-serine/threonine phosphatase from an archaeon
.
J Bacteriol
vol.
177
,
(
22
)
6510
-
6517
.