Publications:  Dr Gabriella Ficz

Patani H, Rushton MD, Higham J, Teijeiro SA, Oxley D, Cutillas P, Sproul D, Ficz G(2020). Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation. Nat Commun vol. 11, (1)

Edelmann J, Holzmann K, Tausch E, Saunderson EA, Jebaraj BMC, Steinbrecher D, Dolnik A, Blätte TJ et al.(2020). Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription. Haematologica vol. 105, (5) 1379-1390.

Saunderson EA, Baker A-M, Williams M, Curtius K, Jones JL, Graham TA, Ficz G(2019). A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples. Nar Genomics and Bioinformatics vol. 2, (1) lqz017-lqz017.

Saunderson EA, Rouault-Pierre K, Gribben JG, Ficz G(2019). CRISPR/Cas9-Targeted De Novo DNA Methylation Is Maintained and Impacts the Colony Forming Potential of Human Hematopoietic CD34+ Cells. Blood vol. 134, (Supplement_1) 2517-2517.

Saunderson EA, Stepper P, Gomm JJ, Hoa L, Morgan A, Allen MD, Jones JL, Gribben JG et al.(2017). Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors. Nature Communications vol. 8, (1)

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q et al.(2017). Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biology vol. 18, (1)

Langie SAS, Cameron KM, Ficz G, Oxley D, Tomaszewski B, Gorniak JP, Maas LM, Godschalk RWL et al.(2017). The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice. Genes (Basel) vol. 8, (2)

Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S et al.(2016). Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms. Proc Natl Acad Sci U S A vol. 113, (43) 12202-12207.

Giehr P, Kyriakopoulos C, Ficz G, Wolf V, Walter J(2016). The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach. PLoS Comput Biol vol. 12, (5)

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F et al.(2015). Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human. Cell vol. 162, (2) 452-453.

Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O et al.(2015). Data resource profile: Accessible resource for integrated epigenomic studies (ARIES). International Journal of Epidemiology vol. 44, (4) 1181-1190.

Ficz G(2015). New insights into mechanisms that regulate DNA methylation patterning. J Exp Biol vol. 218, (Pt 1) 14-20.

McInroy GR, Bell NM, Ficz G, Balasubramanian S, Reik W, Raiber E-A(2015). The Biology and Genomic Localization of Cytosine Modifications. Epigenetic Mechanisms in Cellular Reprogramming,

Peat JR, Dean W, Clark SJ, Krueger F, Smallwood SA, Ficz G, Kim JK, Marioni JC et al.(2014). Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation. Cell Rep vol. 9, (6) 1990-2000.

Ficz G, Gribben JG(2014). Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?. Genomics vol. 104, (5) 352-357.

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F et al.(2014). Resetting transcription factor control circuitry toward ground-state pluripotency in human. Cell vol. 158, (6) 1254-1269.

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D et al.(2013). FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell vol. 13, (3) 351-359.

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D et al.(2013). FGF signalling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Clinical Epigenetics vol. 5, (Suppl 1)

Ficz G, Reik W(2013). Reprogramming by cell fusion: boosted by Tets. Mol Cell vol. 49, (6) 1017-1018.

Iurlaro M, Ficz G, Oxley D, Raiber E-A, Bachman M, Booth MJ, Andrews S, Balasubramanian S et al.(2013). A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol vol. 14, (10)

Heintzmann R, Ficz G(2013). Breaking the resolution limit in light microscopy. Methods Cell Biol vol. 114, 525-544.

Ficz G, Hore T, Santos F, Krueger F, Oxley D, Cook SJ, Xu G, Andrews S et al. (2012). 2i inhibition of Erk1/2 and Gsk3 beta drives genome-wide demethylation to the epigenetic ground state of pluripotency. GENETICS RESEARCH. vol. 94, 355-356.

Raiber E-A, Beraldi D, Ficz G, Burgess HE, Branco MR, Murat P, Oxley D, Booth MJ et al.(2012). Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome Biol vol. 13, (8)

Booth MJ, Branco MR, Ficz G, Oxley D, Krueger F, Reik W, Balasubramanian S(2012). Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science vol. 336, (6083) 934-937.

Branco MR, Ficz G, Reik W(2011). Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet vol. 13, (1) 7-13.

Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S et al.(2011). Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature vol. 473, (7347) 398-402.

Reik W, Popp C, Ficz G, Branco M, Branco M, Krueger C, Hemberger M, Dean W (2010). Epigenetic regulation of imprinting, reprogramming, and lineage commitment in mammals. New Biotechnology. vol. 27,

Farthing CR, Ficz G, Ng RK, Chan C-F, Andrews S, Dean W, Hemberger M, Reik W(2008). Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet vol. 4, (6)

Heintzmann R, Ficz G(2007). Breaking the resolution limit in light microscopy. Methods Cell Biol vol. 81, 561-580.

Heintzmann R, Ficz G(2006). Breaking the resolution limit in light microscopy. Brief Funct Genomic Proteomic vol. 5, (4) 289-301.

Ficz G, Heintzmann R, Arndt-Jovin DJ(2005). Polycomb group protein complexes exchange rapidly in living Drosophila (vol 132, pg 3963, 2005). DEVELOPMENT vol. 132, (17) 4016-4016.

Ficz G, Heintzmann R, Arndt-Jovin DJ(2005). Polycomb group protein complexes exchange rapidly in living Drosophila. Development vol. 132, (17) 3963-3976.

Ficz G, Heintzmann R, Rieger B, Arndt-Jovin DJ (2005). Epigenetic repression in living Drosophila. Stability and dissociation constants of Polycomb group Protein-chromatin complexes. FEBS JOURNAL. vol. 272, 473-473.

Ficz G, Heintzmann R, Rieger B, Arndt-Jovin DJ (2005). Diffusion and disassociation constants for Polycomb group protein-DNA complexes in living Drosophila. A study using fluorescence photobleaching techniques and multicomponent analysis. BIOPHYSICAL JOURNAL. vol. 88, 397A-398A.