Publications: Dr Gabriella Ficz

Ramponi V, Richart L, Kovatcheva M, Stephan-Otto Attolini C, Capellades J, Lord AE, Yanes O, Ficz G et al. ( 2024 ) . H4K20me3-Mediated Repression of Inflammatory Genes is a Characteristic and Targetable Vulnerability of Persister Cancer Cells . Cancer Research

Erblich T, Sauer C, Muyas F, Ficz G, Cortes-Ciriano I, Gribben JG ( 2023 ) . A Novel Approach: Nanopore Sequencing of Native Cell-Free DNA in Diffuse-Large B-Cell Lymphoma Patients . Blood vol. 142 , ( Supplement 1 )

Cheng KCL, Frost JM, Sánchez-Luque FJ, García-Canãdas M, Taylor D, Yang WR, Irayanar B, Sampath S et al. ( 2023 ) . Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation . Epigenetics & Chromatin vol. 16 , ( 1 )

Saunderson EA, Encabo HH, Devis J, Rouault-Pierre K, Piganeau M, Bell CG, Gribben JG, Bonnet D et al. ( 2023 ) . CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny . Proceedings of the National Academy of Sciences of the United States of America vol. 120 , ( 34 )

Pop RT, Pisante A, Nagy D, Martin PCN, Mikheeva LA, Hayat A, Ficz G, Zabet NR ( 2023 ) . Identification of mammalian transcription factors that bind to inaccessible chromatin . Nucleic Acids Research vol. 51 , ( 16 ) 8480 - 8495 .

Hayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S et al. ( 2023 ) . Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening . Disease Models & Mechanisms vol. 16 , ( 2 )

Lord A, Ficz G ( 2022 ) . Corrupted devolution: How normal cells are reborn as cancer precursors . The International Journal of Biochemistry & Cell Biology vol. 149 ,

Saunderson E, Encabo H, Rouault‐Pierre K, Piganeau M, Bonnet D, Gribben J, Ficz G ( 2022 ) . P1411: DUAL EPIGENETIC AND GENETIC EDITING OF PRIMARY HUMAN HAEMATOPOIETIC STEM AND PROGENITOR CELLS . HemaSphere vol. 6 , ( Suppl ) 1295 - 1296 .

Kyriakopoulos C, Nordström K, Kramer PL, Gottfreund JY, Salhab A, Arand J, Müller F, von Meyenn F et al. ( 2022 ) . A comprehensive approach for genome-wide efficiency profiling of DNA modifying enzymes . Cell Reports Methods vol. 2 , ( 3 )

Rushton MD, Saunderson EA, Patani H, Green MR, Ficz G ( 2022 ) . An shRNA kinase screen identifies regulators of UHRF1 stability and activity in mouse embryonic stem cells . Epigenetics vol. 17 , ( 12 ) 1590 - 1607 .

Halsall JA, Andrews S, Krueger F, Rutledge CE, Ficz G, Reik W, Turner BM ( 2021 ) . Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle . Scientific Reports vol. 11 , ( 1 )

Gibson A, Morales V, Bianchi K, Crosbie E, Ficz G, Martin S . Loss of MLH1 regulates a metabolic phenotype in endometrial cancer . Conference: Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response

Patani H, Rushton MD, Higham J, Teijeiro SA, Oxley D, Cutillas P, Sproul D, Ficz G ( 2020 ) . Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation . Nature Communications vol. 11 , ( 1 )

Saunderson EA, Baker A-M, Williams M, Curtius K, Jones JL, Graham TA, Ficz G ( 2019 ) . A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples . Nar Genomics and Bioinformatics vol. 2 , ( 1 ) lqz017 - lqz017 .

Saunderson EA, Rouault-Pierre K, Gribben JG, Ficz G ( 2019 ) . CRISPR/Cas9-Targeted De Novo DNA Methylation Is Maintained and Impacts the Colony Forming Potential of Human Hematopoietic CD34+ Cells . Blood vol. 134 , ( Supplement_1 )

Edelmann J, Holzmann K, Tausch E, Saunderson EA, Jebaraj BMC, Steinbrecher D, Dolnik A, Blätte TJ et al. ( 2019 ) . Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription . Haematologica vol. 105 , ( 5 ) 1379 - 1390 .

Saunderson EA, Stepper P, Gomm JJ, Hoa L, Morgan A, Allen MD, Jones JL, Gribben JG et al. ( 2017 ) . Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors . Nature Communications vol. 8 , ( 1 )

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q et al. ( 2017 ) . Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism . Genome Biology vol. 18 , ( 1 )

Langie SAS, Cameron KM, Ficz G, Oxley D, Tomaszewski B, Gorniak JP, Maas LM, Godschalk RWL et al. ( 2017 ) . The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice . Genes (Basel) vol. 8 , ( 2 )

Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S et al. ( 2016 ) . Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms . Proc Natl Acad Sci U S A vol. 113 , ( 43 ) 12202 - 12207 .

Giehr P, Kyriakopoulos C, Ficz G, Wolf V, Walter J ( 2016 ) . The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach . PLOS Computational Biology vol. 12 , ( 5 )

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F et al. ( 2015 ) . Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human . Cell vol. 162 , ( 2 ) 452 - 453 .

Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O et al. ( 2015 ) . Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES) . International Journal of Epidemiology vol. 44 , ( 4 ) 1181 - 1190 .

Ficz G, Hoppeler HH ( 2015 ) . New insights into mechanisms that regulate DNA methylation patterning . Journal of Experimental Biology vol. 218 , ( 1 ) 14 - 20 .

Peat JR, Dean W, Clark SJ, Krueger F, Smallwood SA, Ficz G, Kim JK, Marioni JC et al. ( 2014 ) . Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation . Cell Reports vol. 9 , ( 6 ) 1990 - 2000 .

McInroy GR, Bell NM, Ficz G, Balasubramanian S, Reik W, Raiber E-A ( 2014 ) . The Biology and Genomic Localization of Cytosine Modifications . Epigenetic Mechanisms in Cellular Reprogramming , Springer Nature

Ficz G, Gribben JG ( 2014 ) . Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? . Genomics vol. 104 , ( 5 ) 352 - 357 .

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F et al. ( 2014 ) . Resetting transcription factor control circuitry toward ground-state pluripotency in human . Cell vol. 158 , ( 6 ) 1254 - 1269 .

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D et al. ( 2013 ) . FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency . Cell Stem Cell vol. 13 , ( 3 ) 351 - 359 .

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D et al. ( 2013 ) . FGF signalling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency . Clinical Epigenetics vol. 5 , ( Suppl 1 )

Ficz G, Reik W ( 2013 ) . Reprogramming by cell fusion: boosted by Tets . Mol Cell vol. 49 , ( 6 ) 1017 - 1018 .

Iurlaro M, Ficz G, Oxley D, Raiber E-A, Bachman M, Booth MJ, Andrews S, Balasubramanian S et al. ( 2013 ) . A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation . Genome Biol vol. 14 , ( 10 )

Heintzmann R, Ficz G ( 2013 ) . Breaking the resolution limit in light microscopy . Methods Cell Biol vol. 114 , 525 - 544 .

Raiber E-A, Beraldi D, Ficz G, Burgess HE, Branco MR, Murat P, Oxley D, Booth MJ et al. ( 2012 ) . Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase . Genome Biol vol. 13 , ( 8 )

Booth MJ, Branco MR, Ficz G, Oxley D, Krueger F, Reik W, Balasubramanian S ( 2012 ) . Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution . Science vol. 336 , ( 6083 ) 934 - 937 .

Ficz G, Hore T, Santos F, Krueger F, Oxley D, Cook SJ, Xu G, Andrews S et al. ( 2012 ) . 2i inhibition of Erk1/2 and Gsk3β drives genome-wide demethylation to the epigenetic ground state of pluripotency . GENETICS RESEARCH . vol. 94 , 355 - 356 .

Branco MR, Ficz G, Reik W ( 2011 ) . Uncovering the role of 5-hydroxymethylcytosine in the epigenome . Nat Rev Genet vol. 13 , ( 1 ) 7 - 13 .

Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S et al. ( 2011 ) . Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation . Nature vol. 473 , ( 7347 ) 398 - 402 .

Reik W, Popp C, Ficz G, Branco M, Branco M, Krueger C, Hemberger M, Dean W ( 2010 ) . Epigenetic regulation of imprinting, reprogramming, and lineage commitment in mammals . New Biotechnology . vol. 27 ,

Ficz G, Farthing CR, Reik W ( 2009 ) . The Epigenomic Landscape of Reprogramming in Mammals . Epigenomics , Springer Nature

Farthing CR, Ficz G, Ng RK, Chan C-F, Andrews S, Dean W, Hemberger M, Reik W ( 2008 ) . Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes . PLoS Genet vol. 4 , ( 6 )

Heintzmann R, Ficz G ( 2007 ) . Breaking the resolution limit in light microscopy . Methods Cell Biol vol. 81 , 561 - 580 .

Heintzmann R, Ficz G ( 2006 ) . Breaking the resolution limit in light microscopy . Brief Funct Genomic Proteomic vol. 5 , ( 4 ) 289 - 301 .

Ficz G, Heintzmann R, Arndt-Jovin DJ ( 2005 ) . Erratum: Polycomb group protein complexes exchange rapidly in living Drosophila (Development vol. 132 (3963-3976)) . Development vol. 132 , ( 17 )

Ficz G, Heintzmann R, Arndt-Jovin DJ ( 2005 ) . Polycomb group protein complexes exchange rapidly in living Drosophila . Development vol. 132 , ( 17 ) 3963 - 3976 .

Ficz G, Heintzmann R, Rieger B, Arndt-Jovin DJ ( 2005 ) . Diffusion and disassociation constants for Polycomb group protein-DNA complexes in living Drosophila. A study using fluorescence photobleaching techniques and multicomponent analysis . BIOPHYSICAL JOURNAL . vol. 88 , 397A - 398A .

Ficz G, Heintzmann R, Rieger B, Arndt-Jovin DJ ( 2005 ) . Epigenetic repression in living <i>Drosophila</i>.: Stability and dissociation constants of Polycomb group Protein-chromatin complexes . FEBS JOURNAL . vol. 272 , 473 - 473 .

Ficz G, Heintzmann R, Arndt-Jovin DJ ( 2005 ) . Polycomb group protein complexes exchange rapidly in living <i>Drosophila</i> (vol 132, pg 3963, 2005) . DEVELOPMENT vol. 132 , ( 17 ) 4016 - 4016 .