Publications: Prof Panagiotis Deloukas
Hodgson S, Williamson A, Bigossi M, Stow D, Jacobs BM, Samuel M, Gafton J, Zöllner J et al.
(
2024
)
.
Genetic basis of early onset and progression of type 2 diabetes in South Asians
.
Nature Medicine1
-
9
.
Hamilton F, Schurz H, Yates TA, Gilchrist JJ, Möller M, Naranbhai V, Ghazal P, Timpson NJ et al.
(
2024
)
.
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
.
The Lancet Microbe
Jacobs BM, Stow D, Hodgson S, Zöllner J, Samuel M, Kanoni S, Bidi S, Walter K et al.
(
2024
)
.
Genetic architecture of routinely acquired blood tests in a British South Asian cohort
.
Nature Communications
vol.
15
,
(
1
)
Shore CJ, Villicaña S, Moustafa JSE-S, Roberts AL, Gunn DA, Bataille V, Deloukas P, Spector TD et al.
(
2024
)
.
Genetic effects on the skin methylome in healthy older twins
.
American Journal of Human Genetics
vol.
111
,
(
9
)
1932
-
1952
.
Gomez EA, De Matteis R, Udomjarumanee P, Team GAHR, Akhtar S, Anwar M, Arciero E, Asgar O et al.
(
2024
)
.
An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections
.
Blood
vol.
144
,
(
4
)
420
-
434
.
Papadopoulou A, Harding D, Slabaugh G, Marouli E, Deloukas P
(
2024
)
.
Prediction of atrial fibrillation and stroke using machine learning models in UK Biobank
.
Heliyon
vol.
10
,
(
7
)
Babajide O, Kjaergaard AD, Deng W, Kuś A, Sterenborg RBTM, Åsvold BO, Burgess S, Teumer A et al.
(
2024
)
.
The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study
.
Borderline Personality Disorder and Emotion Dysregulation
vol.
11
,
(
1
)
Slabaugh G, Beltran L, Rizvi H, Deloukas P, Marouli E
(
2023
)
.
Applications of machine and deep learning to thyroid cytology and histopathology: a review
.
Frontiers in Oncology
vol.
13
,
Papadopoulou A, Åsvold BO, Burgess S, Kuś A, Medici M, Sterenborg R, Teumer A, Deloukas P et al.
(
2023
)
.
Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study
.
Thyroid
vol.
33
,
(
12
)
1476
-
1482
.
Quaye LNK, Dalzell CE, Deloukas P, Smith AJP
(
2023
)
.
The Genetics of Coronary Artery Disease: A Vascular Perspective
.
Cells
vol.
12
,
(
18
)
Giardoglou P, Deloukas P, Dedoussis G, Beis D
(
2023
)
.
Cfdp1 Is Essential for Cardiac Development and Function
.
Cells
vol.
12
,
(
15
)
Kurniansyah N, Goodman MO, Khan AT, Wang J, Feofanova E, Bis JC, Wiggins KL, Huffman JE et al.
(
2023
)
.
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups
.
Nature Communications
vol.
14
,
(
1
)
Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al.
(
2023
)
.
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
.
Nature
vol.
618
,
(
7965
)
e19
-
e20
.
Zöllner J, Finer S, Linton KJ, van Heel DA, Williamson C, Dixon PH
(
2023
)
.
Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom
.
Scientific Reports
vol.
13
,
(
1
)
Burley K, Fitzgibbon L, van Heel D, Team GHR, Akhtar S, Anwar M, Arciero E, Asgar O et al.
(
2023
)
.
PIK3R3 is a candidate regulator of platelet count in people of Bangladeshi ancestry
.
Research and Practice in Thrombosis and Haemostasis
vol.
7
,
(
4
)
Visvikis-Siest S, Stathopoulou MG, Sunder-Plassmann R, Alizadeh BZ, Barouki R, Chatzaki E, Dagher G, Dedoussis G et al.
(
2023
)
.
The 10th Santorini conference: Systems medicine, personalised health and therapy. “The odyssey from hope to practice: Patient first. Keep Ithaca always in your mind”, Santorini, Greece, 23–26 May 2022
.
Frontiers in Genetics
vol.
14
,
Kalafati IP, Dimitriou M, Revenas K, Kokkinos A, Deloukas P, Dedoussis GV
(
2023
)
.
TM6SF2-rs58542926 Genetic Variant Modifies the Protective Effect of a “Prudent” Dietary Pattern on Serum Triglyceride Levels
.
Nutrients
vol.
15
,
(
5
)
Kafyra M, Kalafati IP, Dimitriou M, Grigoriou E, Kokkinos A, Rallidis L, Kolovou G, Trovas G et al.
(
2023
)
.
Robust Bioinformatics Approaches Result in the First Polygenic Risk Score for BMI in Greek Adults
.
Journal of Personalized Medicine
vol.
13
,
(
2
)
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al.
(
2022
)
.
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
.
Genome Biology
vol.
23
,
(
1
)
Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M et al.
(
2022
)
.
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
.
Nature Genetics
vol.
54
,
(
12
)
1803
-
1815
.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al.
(
2022
)
.
A saturated map of common genetic variants associated with human height
.
Nature
vol.
610
,
(
7933
)
704
-
712
.
CC R, JRJ I, S O-G, WM C, Cruz DS, H Y, AJ C, DJM C et al.
(
2022
)
.
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
.
Nguyen H, Solomonson M, Palotie A, Davis L, Lee S, Priest J, Sankaran VG, van Heel D et al.
(
2022
)
.
A first update on mapping the human genetic architecture of COVID-19
.
Nature
vol.
608
,
(
7921
)
e1
-
e10
.
Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B et al.
(
2022
)
.
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
.
Nature Communications
vol.
13
,
(
1
)
Dam V, Onland-Moret NC, Burgess S, Chirlaque M-D, Peters SAE, Schuit E, Tikk K, Weiderpass E et al.
(
2022
)
.
Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization
.
The Journal of Clinical Endocrinology & Metabolism
vol.
107
,
(
7
)
e2952
-
e2961
.
Kjaergaard AD, Teumer A, Marouli E, Deloukas P, Kuś A, Sterenborg R, Åsvold BO, Medici M et al.
(
2022
)
.
Thyroid function, pernicious anemia and erythropoiesis: a two-sample Mendelian randomization study
.
Human Molecular Genetics
vol.
31
,
(
15
)
2548
-
2559
.
Amanatidou AI, Kaliora AC, Amerikanou C, Stojanoski S, Milosevic N, Vezou C, Beribaka M, Banerjee R et al.
(
2022
)
.
Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study
.
International Journal of Environmental Research and Public Health
vol.
19
,
(
2
)
Hawe JS, Wilson R, Schmid KT, Zhou L, Lakshmanan LN, Lehne BC, Kühnel B, Scott WR et al.
(
2022
)
.
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
.
Nature Genetics
vol.
54
,
(
1
)
18
-
29
.
Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al.
(
2021
)
.
The power of genetic diversity in genome-wide association studies of lipids
.
Nature
vol.
600
,
(
7890
)
675
-
679
.
Bourgeois S, Carr DF, Musumba CO, Penrose A, Esume C, Morris AP, Jorgensen AL, Zhang JE et al.
(
2021
)
.
Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration
.
EBioMedicine
vol.
74
,
Marouli E, Yusuf L, Kjaergaard AD, Omar R, Kuś A, Babajide O, Sterenborg R, Åsvold BO et al.
(
2021
)
.
Thyroid Function and the Risk of Alzheimer's Disease: A Mendelian Randomization Study
.
Thyroid
vol.
31
,
(
12
)
1794
-
1799
.
Xie T, Gorenjak V, Stathopoulou MG, Dadé S, Marouli E, Masson C, Murray H, Lamont J et al.
(
2021
)
.
Epigenome-wide association study detects a novel loci associated with central obesity in healthy subjects
.
BMC Medical Genomics
vol.
14
,
(
1
)
Papadopoulou A, Musa H, Sivaganesan M, McCoy D, Deloukas P, Marouli E
(
2021
)
.
COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases
.
PLoS ONE
vol.
16
,
(
9 September
)
Boer CG, Hatzikotoulas K, Southam L, Stefánsdóttir L, Zhang Y, de Almeida RC, Wu TT, Zheng J et al.
(
2021
)
.
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
.
Cell
vol.
184
,
(
18
)
4784
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4818.e17
.
Ellervik C, Mora S, Kuś A, Åsvold B, Marouli E, Deloukas P, Sterenborg RBTM, Teumer A et al.
(
2021
)
.
Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study
.
Thyroid
vol.
31
,
(
9
)
1305
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1315
.
Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen W-M, Santa Cruz DF, Yang H, Cutler AJ, Crouch DJM et al.
(
2021
)
.
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
.
Nature Genetics
vol.
53
,
(
7
)
962
-
971
.
Kuś A, Kjaergaard AD, Marouli E, Del Greco MF, Sterenborg RBTM, Chaker L, Peeters RP, Bednarczuk T et al.
(
2021
)
.
Thyroid Function and Mood Disorders: A Mendelian Randomization Study
.
Thyroid
vol.
31
,
(
8
)
1171
-
1181
.
Kanoni S, Kumar S, Amerikanou C, Kurth MJ, Stathopoulou MG, Bourgeois S, Masson C, Kannt A et al.
(
2021
)
.
Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD
.
Frontiers in Immunology
vol.
12
,
Amerikanou C, Kanoni S, Kaliora AC, Barone A, Bjelan M, D'Auria G, Gioxari A, Gosalbes MJ et al.
(
2021
)
.
Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial
.
Molecular Nutrition & Food Research
vol.
65
,
(
10
)
Giardoglou P, Bournele D, Park M, Kanoni S, Dedoussis GV, Steinberg SF, Deloukas P, Beis D
(
2021
)
.
A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2
.
Biology Open
vol.
10
,
(
3
)
Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al.
(
2021
)
.
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
.
Nature Communications
vol.
12
,
(
1
)
Kjaergaard AD, Marouli E, Papadopoulou A, Deloukas P, Kuś A, Sterenborg R, Teumer A, Burgess S et al.
(
2021
)
.
Thyroid function, sex hormones and sexual function: a Mendelian randomization study
.
European Journal of Epidemiology
vol.
36
,
(
3
)
335
-
344
.
Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J et al.
(
2021
)
.
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
.
Human Molecular Genetics
.
vol.
30
,
393
-
409
.
Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al.
(
2021
)
.
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
.
Nature Communications
vol.
12
,
(
1
)
Cai L, Wheeler E, Kerrison ND, Luan J, Deloukas P, Franks PW, Amiano P, Ardanaz E et al.
(
2020
)
.
Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
.
Scientific Data
vol.
7
,
(
1
)
Cuellar-Partida G, Tung JY, Eriksson N, Albrecht E, Aliev F, Andreassen OA, Barroso I, Beckmann JS et al.
(
2020
)
.
Genome-wide association study identifies 48 common genetic variants associated with handedness
.
Nature Human Behaviour
vol.
5
,
(
1
)
59
-
70
.
Kuś A, Marouli E, Del Greco M. F, Chaker L, Bednarczuk T, Peeters RP, Teumer A, Medici M et al.
(
2020
)
.
Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study
.
Thyroid
vol.
31
,
(
5
)
721
-
731
.
Van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, Robertson NR, Mahajan A et al.
(
2020
)
.
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
.
Circulation: Genomic and Precision Medicine
vol.
13
,
(
6
)
640
-
648
.
Ai-Ghalayini KW, Salama MA, Al Mahdi HB, Al-Harthi S, Alhejily WA, Alasnag MA, Tasbhji NO, Al-Quwaie DAH et al.
(
2020
)
.
Identification of Genetic Variants Associated With Myocardial Infarction in Saudi Arabia
.
The Heart Surgery Forum
vol.
23
,
(
4
)
e517
-
e523
.
Mahmoodi BK, Tragante V, Kleber ME, Holmes MV, Schmidt AF, McCubrey RO, Howe LJ, Direk K et al.
(
2020
)
.
Association of Factor V Leiden With Subsequent Atherothrombotic Events
.
Circulation
vol.
142
,
(
6
)
546
-
555
.
Villar D, Frost S, Deloukas P, Tinker A
(
2020
)
.
The contribution of non-coding regulatory elements to cardiovascular disease
.
Open Biology
vol.
10
,
(
7
)
200088
-
200088
.
Marouli E, Kus A, Del Greco M F, Chaker L, Peeters R, Teumer A, Deloukas P, Medici M
(
2020
)
.
Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study
.
The Journal of Clinical Endocrinology & Metabolism
vol.
105
,
(
8
)
Fabre MA, McKerrell T, Zwiebel M, Vijayabaskar MS, Park N, Wells PM, Rad R, Deloukas P et al.
(
2020
)
.
Concordance for clonal hematopoiesis is limited in elderly twins
.
Blood
vol.
135
,
(
4
)
269
-
273
.
Schunkert H, Erdmann J, Samani NJ, Deloukas P, Zeng L
(
2020
)
.
Genetics of educational attainment and coronary risk in Mendelian randomization studies
.
European Heart Journal
vol.
41
,
(
7
)
894
-
895
.
Huang T, Wang T, Zheng Y, Ellervik C, Li X, Gao M, Fang Z, Chai JF et al.
(
2019
)
.
Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study
.
JAMA network open
vol.
2
,
(
9
)
e1910915
-
e1910915
.
Murphy AM, Smith CE, Murphy LM, Follis JL, Tanaka T, Richardson K, Noordam R, Lemaitre RN et al.
(
2019
)
.
Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals
.
Molecular Nutrition and Food Research
vol.
63
,
(
22
)
Hess JL, Tylee DS, Mattheisen M, Børglum AD, Als TD, Grove J, Werge T, Mortensen PB et al.
(
2019
)
.
A polygenic resilience score moderates the genetic risk for schizophrenia
.
Molecular Psychiatry
vol.
26
,
(
3
)
800
-
815
.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M et al.
(
2019
)
.
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
.
Nature Genetics
vol.
51
,
(
9
)
1423
-
1424
.
Fabre M, McKerrell T, Zwiebel M, Vijayabaskar M, Rad R, Deloukas P, Small K, Steves CJ et al.
(
2019
)
.
PF196 IDENTICAL TWINS DO NOT DISPLAY INCREASED CONCORDANCE FOR CLONAL HEMATOPOIESIS
.
HemaSphere
vol.
3
,
(
S1
)
Zeng L, Ntalla I, Kessler T, Kastrati A, Erdmann J, Group BCCCW, Danesh J, Watkins H et al.
(
2019
)
.
Genetically modulated educational attainment and coronary disease risk
.
European Heart Journal
vol.
40
,
(
29
)
2413
-
2420
.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.
(
2019
)
.
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
.
Nature Genetics
vol.
51
,
(
7
)
1191
-
1192
.
Group MRODCW, Huang T, Sun D, Heianza Y, Bergholdt HK, Gao M, Fang Z, Ding M et al.
(
2019
)
.
Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies
.
Clinical Chemistry
vol.
65
,
(
6
)
751
-
760
.
Ntalla I, Kanoni S, Zeng L, Giannakopoulou O, Danesh J, Watkins H, Samani NJ, Deloukas P et al.
(
2019
)
.
Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases
.
Journal of the American College of Cardiology
vol.
73
,
(
23
)
2932
-
2942
.
Chen Z, Chen JA, Shatunov A, Jones AR, Kravitz SN, Huang AY, Lawrence L, Lowe JK et al.
(
2019
)
.
Genome‐wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy
.
Movement Disorders
vol.
34
,
(
7
)
1049
-
1059
.
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al.
(
2019
)
.
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
.
Communications Biology
vol.
2
,
(
1
)
Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E et al.
(
2019
)
.
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
.
Commun Biol
vol.
2
,
(
1
)
Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A et al.
(
2019
)
.
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events
.
Circ Genom Precis Med
vol.
12
,
(
4
)
e002471
-
e002471
.
Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A et al.
(
2019
)
.
Subsequent Event Risk in Individuals With Established Coronary Heart Disease
.
Circ Genom Precis Med
vol.
12
,
(
4
)
e002470
-
e002470
.
Allum F, Hedman ÅK, Shao X, Cheung WA, Vijay J, Guénard F, Kwan T, Simon M-M et al.
(
2019
)
.
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
.
Nature Communications
vol.
10
,
(
1
)
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M et al.
(
2019
)
.
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
.
Nature Genetics
vol.
51
,
(
3
)
414
-
430
.
Xie T, Gorenjak V, Stathopoulou MG, Dadé S, Marouli E, Masson C, Murray H, Lamont J et al.
(
2019
)
.
Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS)
.
International Journal of Molecular Sciences
vol.
20
,
(
5
)
Harold D, Connolly S, Riley BP, Kendler KS, McCarthy SE, McCombie WR, Richards A, Owen MJ et al.
(
2019
)
.
Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
.
American Journal of Medical Genetics Part B Neuropsychiatric Genetics
vol.
180
,
(
3
)
223
-
231
.
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al.
(
2019
)
.
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
.
Nature Genetics
vol.
51
,
(
3
)
452
-
469
.
Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ et al.
(
2019
)
.
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals
.
Clinical Pharmacology & Therapeutics
vol.
105
,
(
6
)
1477
-
1491
.
Vackova Z, Niebisch S, Triantafyllou T, Becker J, Hess T, Kreuser N, Kanoni S, Deloukas P et al.
(
2019
)
.
First genotype‐phenotype study reveals HLA‐DQβ1 insertion heterogeneity in high‐resolution manometry achalasia subtypes
.
United European Gastroenterology Journal
vol.
7
,
(
1
)
45
-
51
.
Iglesias AI, Mishra A, Vitart V, Bykhovskaya Y, Höhn R, Springelkamp H, Cuellar-Partida G, Gharahkhani P et al.
(
2019
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