Publications:  Dr Melissa Chan

Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD(2019). Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). Br J Pharmacol vol. 176, (8) 988-999.

Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M et al.(2018). Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight vol. 3, (21)

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H et al.(2018). Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment". Circ Res vol. 122, (10) e84-e85.

Chan MV, Leadbeater PD, Watson SP, Warner TD(2018). Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. Platelets1-4.

Chan MV, Armstrong PC, Warner TD(2018). 96-well plate-based aggregometry. Platelets1-6.

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H et al.(2018). Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M. Circ Res vol. 122, (4) 555-559.

Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, CHAN MV, Armstrong PC, Warner TD et al.(2018). Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels. Acta Physiol (Oxf)

VULLIAMY P, GILLESPIE S, ARMSTRONG P, CHAN M, DAVENPORT R, WARNER T, BROHI K (2017). Platelets Shift Towards a Procoagulant and Proin ammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones. Circulation. Conference: American Heart Association Scientific Sessions (Anaheim, CA) from: 11/11/2017 to: 15/11/2017, vol. e448-467,

Ahmetaj-Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan MV, Gashaw H, Galaris G, Mazi S et al.(2017). Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing. Biochem Biophys Res Commun vol. 484, (4) 762-766.

ARMSTRONG PCJ, hoefer T, knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD(2017). Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies. Arteriosclerosis, Thrombosis, and Vascular Biology

Ferreira P, Armstrong P, Chan M, Warner T (2016). SOLUBLE GUANYLATE CYCLASE ACTIVATORS AS COMBINATION ANTI-PLATELET THERAPY WITH P2Y12 INHIBITORS AND PDE INHIBITORS: IN VIVO AND EX VIVO STUDIES. HEART. vol. 102, A118-A119.

Knowles R, D'Silva L, Stanford S, Armstrong P, Chan M, Tucker A, Ferreira P, Sabra A et al. (2016). INSIGHTS INTO THE ROLE OF PLATELETS IN FIBRIN CLOT FORMATION AND THE EFFICACY OF ANTI-PLATELET THERAPIES. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 67, 2127-2127.

Chan MV, Knowles RBM, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PCJ, Mitchell JA et al.(2016). P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation. Br J Clin Pharmacol vol. 81, (4) 621-633.

Warner TD, Armstrong PC, Chan MV, Knowles RB(2016). The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy. Expert Rev Hematol vol. 9, (3) 223-225.

Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K et al.(2016). Association of MicroRNAs and YRNAs With Platelet Function. Circ Res vol. 118, (3) 420-432.

Kirkby NS, Chan MV, Zaiss AK, Garcia-Vaz E, Jiao J, Berglund LM, Verdu EF, Ahmetaj-Shala B et al.(2016). Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways. Proc Natl Acad Sci U S A vol. 113, (2) 434-439.

Paul-Clark M, Elsheikh W, Kirkby N, Chan M, Devchand P, Agbor TA, Flannigan KL, Cheadle C et al.(2016). Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis. PLoS One vol. 11, (2)

Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD(2015). Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy. Arterioscler Thromb Vasc Biol vol. 35, (10) 2122-2133.

Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD(2015). Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Blood vol. 126, (10) e11-e18.

Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al. (2015). The effectiveness of P2Y12 receptor blockade is strongly determined by the presence of endothelial Mediators prostacyclin and nitric oxide. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. vol. 13, 784-784.

Lordkipanidze M, Lowe GC, Kirkby NS, Chan MV, Lundberg MH, Morgan NV, Bem D, Nisar SP et al.(2014). Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay. BLOOD vol. 123, (8) E11-E22.

Lordkipanidze M, Chan MV, Lowe GC, Dawood BB, Warner TD, Watson SP, Grp UKGAPPS (2013). Head-to-head comparison of the optimul assay (96-well plate aggregometry) with gold standard light transmission aggregometry for detection of acquired and inherited platelet defects. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. vol. 11, 43-44.

Kirkby NS, Chan MV, Lundberg MH, Massey KA, Edmands WMB, Mackenzie LS, Holmes E, Nicolaou A et al.(2013). Aspirin-triggered 15-epi-lipoxin A<inf>4</inf> predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: Implications for a clinical test. FASEB Journal vol. 27, (10) 3938-3946.

Kirkby NS, Lundberg MH, Chan MV, Vojnovic I, Solomon AB, Emerson M, Mitchell JA, Warner TD(2013). Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide. Proc Natl Acad Sci U S A vol. 110, (39) 15782-15787.

Kirkby NS, Zaiss AK, Wright WR, Jiao J, Chan MV, Warner TD, Herschman HR, Mitchell JA(2013). Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Biochem Biophys Res Commun vol. 438, (2) 249-256.

Bubb KJ, Wen H, Panayiotou CM, Finsterbusch M, Khan FJ, Chan MV, Priestley JV, Baker MD et al.(2013). Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A. Hypertension vol. 62, (2) 426-433.

Chan MV, Bubb KJ, Noyce A, Villar IC, Duchene J, Hobbs AJ, Scotland RS, Ahluwalia A(2012). Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation. Br J Pharmacol vol. 167, (4) 805-817.

Mcloughlin TF, Chan MV, Warner TD, Hart DP (2012). Validation of a novel, high-throughput platelet aggregation technique. HAEMOPHILIA. vol. 18, 18-19.

Chan MV, Warner TD(2012). Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings. Platelets vol. 23, (5) 404-408.

Kirkby NS, Leadbeater PDM, Chan MV, Nylander S, Mitchell JA, Warner TD(2011). Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel. J Thromb Haemost vol. 9, (10) 2103-2105.

Kirkby NS, Leadbeater PDM, Chan MV, Nylander S, Mitchell JA, Warner TD(2011). INHIBITION OF ADP- AND THROMBOXANE-DEPENDENT PATHWAYS OF PLATELET AGGREGATION BY THE P2Y12 ANTAGONISTS, TICAGRELOR AND PRASUGREL. HEART vol. 97, (20) 9-9.

Kirkby NS, Leadbeater PDM, Chan MV, Nylander S, Mitchell JA, Warner TD (2011). Aspirin augments the anti-platelet effects of partial but not complete P2Y(12) receptor blockade by ticagrelor. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. vol. 9, 780-780.

Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al.(2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol vol. 31, (5) 1075-1083.

Armstrong PCJ, Leadbeater PD, Chan MV, Kirkby NS, Jakubowski JA, Mitchell JA, Warner TD(2011). In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation. J Thromb Haemost vol. 9, (3) 552-561.

Chan MV, Armstrong PCJ, Papalia F, Kirkby NS, Warner TD(2011). Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Platelets vol. 22, (7) 485-494.

Chan MV, Hobbs AJ, Scotland RS, Ahluwalia A (2008). Nitric oxide-induced relaxation in female resistance arteries is endothelium-dependent. BASIC CLIN PHARMACOL. vol. 102, 38-38.

Chan M, Villar I, Scotland R, Ahluwalia A (2008). Endothelium-derived hyperpolarising factor (EDHF) underlies sex-differences in the pressure-induced myogenic response. FASEB JOURNAL. vol. 22,