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Publications:  Dr Myles Lewis

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al.(2020). B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Arthritis and Rheumatology
10.1002/art.41184
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63258
John CR, Watson D, Barnes MR, Pitzalis C, Lewis MJ(2020). Spectrum: Fast density-aware spectral clustering for single and multi-omic data. Bioinformatics vol. 36, (4) 1159-1166.
10.1093/bioinformatics/btz704
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64588
John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M(2020). M3C: Monte Carlo reference-based consensus clustering. Scientific Reports vol. 10, (1)
10.1038/s41598-020-58766-1
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63004
Pagani S, Bellan M, Mauro D, Castello LM, Avanzi GC, Lewis MJ, Sainaghi PP, Pitzalis C et al.(2020). New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis. Disease Markers vol. 2020, Article 1614627,
10.1155/2020/1614627
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62984
Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C et al.(2020). Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine
10.1038/s41591-020-0939-8
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al.(2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. Journal of Autoimmunity vol. 105,
10.1016/j.jaut.2019.06.008
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58983
Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R et al.(2019). Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: Results from the pathobiology of early arthritis cohort (PEAC). Annals of the Rheumatic Diseases vol. 78, (12) 1642-1652.
10.1136/annrheumdis-2019-215751
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63523
Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J et al.(2019). Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring. Cell Metabolism
10.1016/j.cmet.2019.10.004
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61253
Antbring R, Cunningham M, Bull R, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D (2019). Lupus Teledematology: A Pilot Project to Evaluate the Plausibility of a Rapid Access Dermatology Service for Lupus Patients. ARTHRITIS & RHEUMATOLOGY. vol. 71,
Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al.(2019). Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis. Rheumatology
10.1093/rheumatology/kez358
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62220
Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al.(2019). Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes. Cell Reports vol. 28, 2455-2470.
10.1016/j.celrep.2019.07.091
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59563
Humby F, Lewis M, Townsend MJ, Pitzalis C(2019). Response to 'Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients' by Humby et al. Ann Rheum Dis
10.1136/annrheumdis-2019-215903
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59783
Humby F, Lewis M, Ramamoorthi N, Hackney JA, Barnes MR, Bombardieri M, Setiadi AF, Kelly S et al.(2019). Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients. Annals of the rheumatic diseases vol. 78, (6) 761-772.
10.1136/annrheumdis-2018-214539
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58941
Mauro D, Rivellese F, Manou-Stathopoulou S, Goldmann K, Pyne D, Ciccia F, Pitzalis C, Lewis M (2019). THE EFFECT OF DIMETHYL FUMARATE ON PLASMABLAST DIFFERENTIATION TRANSCRIPTIONAL PROGRAMMES IN SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 1077-1077.
10.1136/annrheumdis-2019-eular.7792
Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. (2019). THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES. vol. 78, 1548-1548.
10.1136/annrheumdis-2019-eular.6343
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al.(2019). PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. Annals of the Rheumatic Diseases vol. 78, (5) 600-609.
10.1136/annrheumdis-2018-213799
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56182
Twohig JP, Cardus Figueras A, Andrews R, Wiede F, Cossins BC, Derrac Soria A, Lewis MJ, Townsend MJ et al.(2019). Activation of naïve CD4 <sup>+</sup> T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 <sup>+</sup> T cells. Nature Immunology vol. 20, (4) 458-470.
10.1038/s41590-019-0350-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59555
Almathkouri A, Pyne D, Rajakariar R, Cove-Smith A, Lewis M, Pakozdi A (2019). PREVALENCE OF FIBROMYALGIA IN A COHORT OF RENAL AND NON-RENAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS. RHEUMATOLOGY. vol. 58, 196-196.
Khan A, Pakozdi A, Rajakariar R, Cove-Smith A, Lewis M, Pyne D (2019). SLEEP DISTURBANCES IN LUPUS PATIENTS. RHEUMATOLOGY. vol. 58,
Hensor EMA, McKeigue P, Ling SF, Colombo M, Barrett JH, Nam JL, Freeston J, Buch MH et al.(2019). Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis. Rheumatology (Oxford)
10.1093/rheumatology/kez049
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56623
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ et al.(2019). The autoimmune susceptibility gene C5orf30 regulates macrophage-mediated resolution of inflammation. Journal of Immunology vol. 202, (4) 1069-1078.
10.4049/jimmunol.1801155
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55324
Nerviani A, Mauro D, Gilio M, Grembiale RD, Lewis MJ(2018). To supplement or not to supplement? The rationale of vitamin D supplementation in systemic lupus erythematosus. Open Rheumatology Journal vol. 12, 226-247.
10.2174/1874312901812010226
https://qmro.qmul.ac.uk/xmlui/handle/123456789/57680
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al.(2018). The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol vol. 14, (1) 53-60.
10.1038/nrrheum.2017.200
https://qmro.qmul.ac.uk/xmlui/handle/123456789/35063
Rivellese F, Mauro D, Congia M, Pontarini E, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ (2018). Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY. vol. 70,
Lewis MJ, McAndrew MB, Wheeler C, Workman N, Agashe P, Koopmann J, Uddin E, Morris DL et al.(2018). Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus. Journal of Autoimmunity vol. 91, 1-12.
10.1016/j.jaut.2018.02.009
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39555
Lewis MJ, Barnes MR(2018). RNA sequencing and machine learning as molecular scalpels. Nat Rev Rheumatol vol. 14, (7) 388-390.
10.1038/s41584-018-0012-x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39553
Wheeler LM, Pakozdi A, Rajakariar R, Lewis M, Cove-Smith A, Pyne D (2018). MOVING WITH THE TIMES: SOCIAL MEDIA USE AMONGST LUPUS PATIENTS. RHEUMATOLOGY. vol. 57,
Waller A, Goulden B, Pakozdi A, Lewis M, Rajakariar R, Cove-Smith A, Pyne D (2018). SELF REPORTED ALOPECIA IN AN ETHNICALLY DIVERSE LUPUS COHORT. RHEUMATOLOGY. vol. 57,
Pullabhatla V, Roberts AL, Lewis MJ, Mauro D, Morris DL, Odhams CA, Tombleson P, Liljedahl U et al.(2018). De novo mutations implicate novel genes in systemic lupus erythematosus. Human Molecular Genetics vol. 27, (3) 421-429.
10.1093/hmg/ddx407
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32326
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al.(2018). Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol vol. 14, (2)
10.1038/nrrheum.2018.6
RA-MAP Consortium(2018). Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data. RMD Open vol. 4, (2)
10.1136/rmdopen-2018-000721
Ursini F, Leporini C, Bene F, D'Angelo S, Mauro D, Russo E, De Sarro G, Olivieri I et al.(2017). Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: A systematic review and meta-analysis. Scientific Reports vol. 7, (1)
10.1038/s41598-017-05759-2
https://qmro.qmul.ac.uk/xmlui/handle/123456789/25225
Bahal S, Pyne D, Rajakariar R, Lewis M, Pakozdi A, Grigoriadou S, Cove-Smith A (2017). Anti-C1q Antibodies and Disease Activity in a Multi-Ethnic Lupus Cohort. ARTHRITIS & RHEUMATOLOGY. vol. 69,
Mauro D, Tsang V, Clayton-Lucey IA, Pagani S, Alam F, Pontarini E, Nerviani A, Pakozdi A et al. (2017). Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE. ARTHRITIS & RHEUMATOLOGY. vol. 69,
Etomi O, Cove-Smith A, Rajakariar R, Lewis MJ, Pakozdi A, Pyne D (2017). The Prevalence of Autoimmune Disease in Families of Patients with Systemic Lupus Erythematosus (SLE). a Single Centre Study. ARTHRITIS & RHEUMATOLOGY. vol. 69,
Bombardieri M, Lewis M, Pitzalis C(2017). Ectopic lymphoid neogenesis in rheumatic autoimmune diseases. Nature Reviews Rheumatology
10.1038/nrrheum.2016.217
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19652
Lewis MJ, Jawad AS(2016). The effect of ethnicity and genetic ancestry on the epidemiology, clinical features and outcome of systemic lupus erythematosus. Rheumatologykew399-kew399.
10.1093/rheumatology/kew399
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19700
Mauro D, Lewis MJ, Pullabhatla V, Vyse S, Simpson M, Cunninghame-Graham D, Syvanen AC, Pitzalis C et al. (2016). C1QTNF4 MUTATION IDENTIFIED BY EXOME SEQUENCING IS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND DYSREGULATION OF TNF-INDUCED APOPTOSIS. ANNALS OF THE RHEUMATIC DISEASES. Conference: Annual European Congress of Rheumatology EULAR 2016 vol. 75, 145-154.
10.1136/annrheumdis-2016-eular.4039
Lewis MJ, McAndrew MB, Wheeler C, Workman N, Agashe P, Koopmann J, Uddin E, Zou L et al. (2016). FUNCTIONAL CLUSTERS OF AUTOANTIBODIES TARGETING TLR AND SMAD PATHWAYS DEFINE NEW SUBGROUPS IN SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES. Conference: Annual European Congress of Rheumatology EULAR 2016 vol. 75, 278-278.
10.1136/annrheumdis-2016-eular.6111
Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. (2016). CORRELATION OF SOLUBLE VASCULAR CELL ADHESION MOLECULE 1 WITH B CELL ACTIVATION AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS. RHEUMATOLOGY. Conference: British Society for Rheumatology annual conference 2016 vol. 55, 145-146.
Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al.(2016). Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1. Arthritis Research and Therapy vol. 18, (1)
10.1186/s13075-015-0896-7
https://qmro.qmul.ac.uk/xmlui/handle/123456789/10951
Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ (2015). THE AUTOIMMUNE RISK GENE UBE2L3 IS HIGHLY EXPRESSED DURING B CELL PROLIFERATION AND IS CORRELATED WITH PLASMABLAST AND PLASMA CELL EXPANSION IN SLE. RHEUMATOLOGY. vol. 54, 41-41.
Vyse S, Shields AM, Boeltz S, Leirer D, Gordon PA, Spector TD, Lehner PJ, Walczak H et al. (2015). SLE ASSOCIATED UBE2L3 HAPLOTYPE MODULATES PLASMA CELL DIFFERENTIATION VIA GENOTYPIC REGULATION OF NF-kappa B. ANNALS OF THE RHEUMATIC DISEASES. vol. 74, A19-A20.
10.1136/annrheumdis-2015-207259.45
Lewis M, Vyse S, Shields A, Boeltz S, Gordon P, Spector T, Lehner P, Walczak H et al. (2015). Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus. Lancet. vol. 385 Suppl 1,
10.1016/S0140-6736(15)60324-5
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19703
Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon PA, Spector TD, Lehner PJ, Walczak H et al.(2015). UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. American Journal of Human Genetics vol. 96, (2) 221-234.
10.1016/j.ajhg.2014.12.024
Lewis MJ, Vyse S, Shields AM, Boeltz S, Gordon P, Spector TD, Lehner PJ, Walczak H et al.(2014). UBE2L3 genotype Influences Plasma Cell Proliferation in Systemic Lupus Erythematosus By Regulation of NF-kappa B By the Linear Ubiquitination Assembly Complex. ARTHRITIS & RHEUMATOLOGY vol. 66, S384-S384.
Davies RJ, Sangle SR, Jordan NP, Aslam L, Lewis MJ, Wedgwood R, D'Cruz DP(2013). Rituximab in the treatment of resistant lupus nephritis: therapy failure in rapidly progressive crescentic lupus nephritis. Lupus vol. 22, (6) 574-582.
10.1177/0961203313483376
Lewis MJ, Malik TH, Fossati-Jimack L, Carassiti D, Cook HT, Haskard DO, Botto M(2012). Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia. Arthritis and Rheumatism vol. 64, (8) 2707-2718.
10.1002/art.34451
https://qmro.qmul.ac.uk/xmlui/handle/123456789/19701
Haskard D, Talat M, Lewis M, Leung V, Yun S, Boyle JJ, Botto M (2011). Bifunctional roles of complement and antibodies in atherosclerosis. IMMUNOLOGY. vol. 135, 16-16.
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO(2009). Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation vol. 120, (5) 417-426.
10.1161/CIRCULATIONAHA.109.868158
Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M (2009). COMPLEMENT DYSREGULATION LINKS ACCELERATED ATHEROSCLEROSIS AND GLOMERULONEPHRITIS IN SLE. RHEUMATOLOGY. vol. 48, I15-I16.
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO (2008). IgM deficiency accelerates atherosclerosis: A potential adverse consequence of B cell depletion therapy?. ARTHRITIS AND RHEUMATISM. vol. 58, S934-S934.
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO (2008). Atheroprotective functions of IgM and complement C1q: do low IgM levels and impaired complement activity provide a new link between atherosclerosis and SLE?. RHEUMATOLOGY. vol. 47, II7-II8.
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO(2008). Hierarchical contributions of IgM and complement C1q in protection against murine atherosclerosis. FASEB JOURNAL vol. 22,
Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M (2008). Lupus phenotype accelerates atherosclerosis in a novel mouse model of SLE. RHEUMATOLOGY. vol. 47, II97-II98.
Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO (2007). Serum IgM plays an important protective role in murine atherosclerosis. ATHEROSCLEROSIS. vol. 193, S3-S4.
10.1016/j.atherosclerosis.2007.04.015
Lewis MJ, Botto M(2006). Complement deficiencies in humans and animals: Links to autoimmunity. Autoimmunity vol. 39, (5) 367-378.
10.1080/08916930600739233
Lewis MJ, D'Cruz D(2005). Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus. Lupus vol. 14 Suppl 1, s17-s26.
10.1191/0961203305lu2113oa
Descamps MJL, Lewis MJ, Hart PE, Brew S, Jäger HR, Greenwood R(2004). Brainstem infarction during long-haul air travel. Eur Neurol vol. 52, (3) 181-184.
10.1159/000081862
Lewis M, Gibson T(2003). Systemic lupus erythematous with recurrent Guillain-Barré-like syndrome treated with intravenous immunoglobulins. Lupus vol. 12, (11) 857-859.
10.1191/0961203303lu464cr
Lewis MJ, Greenwood RJ, Brew S, Jäger HR(2003). Economy class stroke syndromes: vertebral artery dissection revisited. J Neurol Neurosurg Psychiatry vol. 74, (11) 1594-1595.
10.1136/jnnp.74.11.1594
Lewis MJ, Chan YP, Lewis RR(2002). Ring lesions in the brain and a mass in the kidney. J R Soc Med vol. 95, (1) 34-35.
10.1258/jrsm.95.1.34
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