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Publications:  Dr Matthew Brooke

Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A et al.(2018). p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Nat Commun vol. 9, (1)
10.1038/s41467-018-03470-y
Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A et al.(2017). Rhomboid family member 2 Regulates cytoskeletal stress associated Keratin 16. Nature Communications vol. 8, 14174-14174.
10.1038/ncomms14174
WOLF C, QIAN Y, BROOKE MA, KELSELL DP, FRANZKE CW(2016). ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C γ1 and protein kinase C pathways. Scientific Reports vol. 6, Article 39780,
10.1038/srep39780
Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T et al.(2015). Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. Sci Signal vol. 8, (401)
10.1126/scisignal.aac5356
Brooke MA, O'Toole EA, Kelsell DP(2014). Exoming into rare skin disease: EGFR deficiency. J Invest Dermatol vol. 134, (10) 2486-2488.
10.1038/jid.2014.228
Brooke MA, Etheridge SL, Kaplan N, Simpson C, O'Toole EA, Ishida-Yamamoto A, Marches O, Getsios S et al.(2014). iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. Hum Mol Genet vol. 23, (15) 4064-4076.
10.1093/hmg/ddu120
Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP et al.(2014). Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. Gut vol. 63, (1) 96-104.
10.1136/gutjnl-2012-303581
Etheridge SL, Brooke MA, Kelsell DP, Blaydon DC(2013). Rhomboid proteins: a role in keratinocyte proliferation and cancer. Cell Tissue Res vol. 351, (2) 301-307.
10.1007/s00441-012-1542-1
Etheridge SL, Brooke MA, Kelsell DP, Blaydon DC(2013). Rhomboid proteins: A role in keratinocyte proliferation and cancer. Cell and Tissue Research vol. 351, (2) 301-307.
10.1007/s00441-012-1542-1
Brooke MA, Nitoiu D, Kelsell DP(2012). Cell-cell connectivity: desmosomes and disease. J Pathol vol. 226, (2) 158-171.
10.1002/path.3027
Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al.(2011). Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med vol. 365, (16) 1502-1508.
10.1056/NEJMoa1100721
MARUTHAPPU T, CHIKH A, FELL B, DELANEY PJ, BROOKE MA, LEVET C, MONCADA-PAZOS A, ISHIDA-YAMAMOTO A et al.. Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16. Nature Communications
10.1038/ncomms14174
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