Publications: Dr Matthew Brooke
Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A et al.(2018).
p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Nat Commun
vol. 9,
(1)
Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A et al.(2017).
Rhomboid family member 2 Regulates cytoskeletal stress associated Keratin 16. Nature Communications
vol. 8,
14174-14174.
WOLF C, QIAN Y, BROOKE MA, KELSELL DP, FRANZKE CW(2016).
ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C γ1 and protein kinase C pathways. Scientific Reports
vol. 6,
Article 39780,
Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T et al.(2015).
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. Sci Signal
vol. 8,
(401)
Brooke MA, O'Toole EA, Kelsell DP(2014).
Exoming into rare skin disease: EGFR deficiency. J Invest Dermatol
vol. 134,
(10)
2486-2488.
Brooke MA, Etheridge SL, Kaplan N, Simpson C, O'Toole EA, Ishida-Yamamoto A, Marches O, Getsios S et al.(2014).
iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. Hum Mol Genet
vol. 23,
(15)
4064-4076.
Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP et al.(2014).
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. Gut
vol. 63,
(1)
96-104.
Etheridge SL, Brooke MA, Kelsell DP, Blaydon DC(2013).
Rhomboid proteins: a role in keratinocyte proliferation and cancer. Cell Tissue Res
vol. 351,
(2)
301-307.
Etheridge SL, Brooke MA, Kelsell DP, Blaydon DC(2013).
Rhomboid proteins: A role in keratinocyte proliferation and cancer. Cell and Tissue Research
vol. 351,
(2)
301-307.
Brooke MA, Nitoiu D, Kelsell DP(2012).
Cell-cell connectivity: desmosomes and disease. J Pathol
vol. 226,
(2)
158-171.
Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al.(2011).
Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med
vol. 365,
(16)
1502-1508.
MARUTHAPPU T, CHIKH A, FELL B, DELANEY PJ, BROOKE MA, LEVET C, MONCADA-PAZOS A, ISHIDA-YAMAMOTO A et al..
Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16. Nature Communications