Publications: Dr Claire Bourke

Phiri TN, Weatherill JW, Monford-Sanchez E, Serrano-Contreras J-I, Melvin C, Kunaka M, Chisenga I, Ngalande P et al. ( 2024 ) . Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: A cross-sectional study protocol . F1000Research vol. 13 ,

Broad J, Robertson RC, Evans C, Perussolo J, Lum G, Piper JD, Loucaides E, Ziruma A et al. ( 2024 ) . Maternal inflammatory and microbial drivers of low birthweight in low- and middle-income countries . Paediatrics and International Child Health vol. 44 , ( 2 ) 79 - 93 .

Bourke C, Evans C, Prendergast A, Kelly M ( 2024 ) . Inflammation and cytomegalovirus viremia during pregnancy drive sex-differentiated differences in mortality and immune development in HIV-exposed infants . Nature Communications vol. 15 , Article 2909 ,

Sturgeon JP, Tome J, Dumbura C, Majo FD, Ngosa D, Mutasa K, Zyambo K, Besa E et al. ( 2024 ) . Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition . Science Translational Medicine vol. 16 , ( 736 ) eadh0673 - eadh0673 .

Bourke C, Robertson R ( 2023 ) . Severe acute malnutrition promotes bacterial binding over pro-inflammatory cytokine secretion by circulating innate immune cells . Science Advances vol. 9 , ( 44 ) Article eadh2284 ,

Phiri TN, Mutasa K, Rukobo S, Govha M, Mushayanembwa P, Mwakamui S, Haider T, Zyambo K et al. ( 2023 ) . Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells . Science Advances vol. 9 , ( 44 ) eadh2284 - eadh2284 .

Sturgeon JP, Mufukari W, Tome J, Dumbura C, Majo FD, Ngosa D, Chandwe K, Kapoma C et al. ( 2023 ) . Risk factors for inpatient mortality among children with severe acute malnutrition in Zimbabwe and Zambia . European Journal of Clinical Nutrition vol. 77 , ( 9 ) 895 - 904 .

Jones HJ, Bourke CD, Swann JR, Robertson RC ( 2023 ) . Malnourished Microbes: Host–Microbiome Interactions in Child Undernutrition . Annual Review of Nutrition vol. 43 , ( 1 ) 327 - 353 .

Sturgeon JP, Njunge JM, Bourke CD, Gonzales GB, Robertson RC, Bwakura-Dangarembizi M, Berkley JA, Kelly P et al. ( 2023 ) . Inflammation: the driver of poor outcomes among children with severe acute malnutrition? . Nutrition Reviews vol. 81 , ( 12 ) 1636 - 1652 .

Smith LE, Chagwena DT, Bourke C, Robertson R, Fernando S, Tavengwa NV, Cairns J, Ndhlela T et al. ( 2022 ) . Child Health, Agriculture and Integrated Nutrition (CHAIN): protocol for a randomised controlled trial of improved infant and young child feeding in rural Zimbabwe . BMJ Open vol. 12 , ( 12 )

Gonzales GB, Bourke CD, Sturgeon JP, Njunge JM, Robertson RC, Kelly PM, Berkley JA ( 2022 ) . Commentary: Mechanisms of kwashiorkor-associated immune suppression: Insights from human, mouse, and pig studies . Frontiers in Immunology vol. 13 ,

Bourke C ( 2022 ) . Stunting status and exposure to infection and inflammation in early life shape anti-bacterial immune cell function among Zimbabwean children . Frontiers in Immunology vol. 13 ,

Bourke C ( 2021 ) . Recovery of children following hospitalization for complicated severe acute malnutrition in Zimbabwe and Zambia . Maternal and Child Nutrition Article MCN-06-21-OA-4922.R1 ,

Thompson A, Bourke C, Roberston R, Shivakumar N, Edwards C, Preston T, Holmes E, Kelly M et al. ( 2021 ) . Understanding the role of the gut in undernutrition: what can technology tell us? . Gut

Bwakura-Dangarembizi M, Dumbura C, Amadi B, Ngosa D, Majo FD, Nathoo KJ, Mwakamui S, Mutasa K et al. ( 2021 ) . Risk factors for postdischarge mortality following hospitalization for severe acute malnutrition in Zimbabwe and Zambia . American Journal of Clinical Nutrition vol. 113 , ( 3 ) 665 - 674 .

Nadimpalli ML, Bourke CD, Robertson RC, Delarocque-Astagneau E, Manges AR, Pickering AJ ( 2020 ) . Can breastfeeding protect against antimicrobial resistance? . BMC Medicine vol. 18 , ( 1 )

Gough E, Bourke C, Berejena C, Shonhai A, Bwakura-Dangarembizi M, Prendergast A, Manges AR ( 2020 ) . Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe . Gut Microbes Article KGMI-20190194R1 ,

Bourke C, Evans C ( 2019 ) . Cotrimoxazole prophylaxis selects for antimicrobial resistance in HIV-exposed uninfected infants . Clinical Infectious Diseases

Bourke C ( 2019 ) . Determinants of urogenital schistosomiasis among pregnant women and its impact on pregnancy outcomes, neonatal deaths and child growth . Journal of Infectious Diseases

Bourke CD, Prendergast AJ ( 2019 ) . The Anti-inflammatory Effects of Cotrimoxazole Prophylaxis for People Living With Human Immunodeficiency Virus in Sub-Saharan Africa . The Journal of Infectious Diseases vol. 222 , ( 3 ) 347 - 350 .

Bourke C, Jones KDJ, Prendergast AJ ( 2019 ) . Current understanding of innate immune cell dysfunction in childhood undernutrition . Frontiers in Immunology

BOURKE CD, PRENDERGAST A, DEAYTON J, PARDIEU C, Naheed C ( 2019 ) . Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation . Science Translational Medicine vol. 11 ,

Sturgeon JP, Bourke CD, PRENDERGAST AJ ( 2019 ) . Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses . The Pediatric Infectious Disease Journal1 - 1 .

BOURKE CD, PRENDERGAST A, ROBERTSON R ( 2019 ) . Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study . BMJ Open

Bourke C ( 2019 ) . Health outcomes in Undernutrition: the role of nutrients, gut dysfunction and the gut microbiome (HUNGer) . Imperial College Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,

Freer JB, Bourke CD, Durhuus GH, Kjetland EF, Prendergast AJ ( 2017 ) . Schistosomiasis in the first 1000 days . The Lancet Infectious Diseases vol. 18 , ( 6 ) e193 - e203 .

BOURKE CD, Berkley JA, Prendergast AJ ( 2016 ) . Immune Dysfunction as a Cause and Consequence of Malnutrition . Trends in Immunology vol. 37 , ( 6 ) Article TREIMM_1280 , 386 - 398 .

Sanin DE, Prendergast CT, Bourke CD, Mountford AP ( 2015 ) . Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive . PLOS Pathogens vol. 11 , ( 5 )

Fukushige M, Mitchell KM, Bourke CD, Woolhouse MEJ, Mutapi F ( 2015 ) . A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model . Frontiers in Immunology vol. 6 ,

Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE et al. ( 2015 ) . Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation . Frontiers in Immunology vol. 6 ,

Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ, Mountford AP ( 2015 ) . Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection . International Journal for Parasitology vol. 45 , ( 4 ) 215 - 224 .

Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T, Mutapi F ( 2014 ) . CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1 . PLOS Neglected Tropical Diseases vol. 8 , ( 8 )

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F ( 2014 ) . Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment . PLOS Neglected Tropical Diseases vol. 8 , ( 5 )

Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP ( 2014 ) . Circulating CD14brightCD16+ ‘Intermediate’ Monocytes Exhibit Enhanced Parasite Pattern Recognition in Human Helminth Infection . PLOS Neglected Tropical Diseases vol. 8 , ( 4 )

Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K et al. ( 2013 ) . Schistosome infection is associated with enhanced whole‐blood IL‐10 secretion in response to cercarial excretory/secretory products . Parasite Immunology vol. 35 , ( 5-6 ) 147 - 156 .

Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE, Mutapi F ( 2012 ) . Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children . PLOS Neglected Tropical Diseases vol. 6 , ( 11 )

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F ( 2012 ) . Integrated Analysis of Innate, Th1, Th2, Th17, and Regulatory Cytokines Identifies Changes in Immune Polarisation Following Treatment of Human Schistosomiasis . The Journal of Infectious Diseases vol. 208 , ( 1 ) 159 - 169 .

Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IYD, Appleby LJ, Bourke CD et al. ( 2012 ) . Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection . PLOS Neglected Tropical Diseases vol. 6 , ( 9 )

Bourke CD, Mutapi F, Nausch N, Photiou DMF, Poulsen LK, Kristensen B, Arnved J, Rønborg S et al. ( 2012 ) . Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response . Clinical & Experimental Allergy vol. 42 , ( 11 ) 1582 - 1595 .

Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T et al. ( 2012 ) . Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium . Scientific Reports vol. 2 , ( 1 )

Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW, Mutapi F ( 2012 ) . Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of Schistosoma haematobium Infection . International Archives of Allergy and Immunology vol. 158 , ( 3 ) 288 - 298 .

Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP ( 2011 ) . The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production . International Journal for Parasitology vol. 41 , ( 13-14 ) 1335 - 1345 .

IMAI N, RUJENI N, NAUSCH N, BOURKE CD, APPLEBY LJ, COWAN G, GWISAI R, MIDZI N et al. ( 2011 ) . Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria . Parasitology vol. 138 , ( 12 ) 1519 - 1533 .

Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N, Mduluza T ( 2011 ) . Schistosoma haematobium Treatment in 1–5 Year Old Children: Safety and Efficacy of the Antihelminthic Drug Praziquantel . PLOS Neglected Tropical Diseases vol. 5 , ( 5 )

Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse MEJ et al. ( 2011 ) . Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels . PLOS ONE vol. 6 , ( 5 )

MUTAPI F, BOURKE C, HARCUS Y, MIDZI N, MDULUZA T, TURNER CM, BURCHMORE R, MAIZELS RM ( 2011 ) . Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4 . Parasite Immunology vol. 33 , ( 3 ) 181 - 192 .

BOURKE CD, MAIZELS RM, MUTAPI F ( 2010 ) . Acquired immune heterogeneity and its sources in human helminth infection . Parasitology vol. 138 , ( 2 ) 139 - 159 .