Publications:  Dr Claire Bourke

Bourke CD, Prendergast AJ(2020). The Anti-inflammatory Effects of Cotrimoxazole Prophylaxis for People Living With Human Immunodeficiency Virus in Sub-Saharan Africa. The Journal of infectious diseases vol. 222, (3) 347-350.

Gough E, Bourke C, Berejena C, Shonhai A, Bwakura-Dangarembizi M, Prendergast A, Manges AR(2020). Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe. Gut Microbes Article KGMI-20190194R1,

Bourke C, Evans C(2019). Cotrimoxazole prophylaxis selects for antimicrobial resistance in HIV-exposed uninfected infants. Clinical Infectious Diseases

Bourke C(2019). Determinants of urogenital schistosomiasis among pregnant women and its impact on pregnancy outcomes, neonatal deaths and child growth. Journal of Infectious Diseases

Bourke C, Jones KDJ, Prendergast AJ(2019). Current understanding of innate immune cell dysfunction in childhood undernutrition. Frontiers in Immunology

BOURKE CD, PRENDERGAST A, DEAYTON J, PARDIEU C, Naheed C(2019). Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation. Science Translational Medicine vol. 11,

Sturgeon JP, Bourke CD, PRENDERGAST AJ(2019). Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses. The Pediatric Infectious Disease Journal1-1.

BOURKE CD, PRENDERGAST A, ROBERTSON R(2019). Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study. BMJ Open

Freer JB, Bourke CD, Durhuus GH, Kjetland EF, Prendergast AJ(2018). Schistosomiasis in the first 1000 days. The Lancet Infectious Diseases vol. 18, (6) e193-e203.

BOURKE CD, Berkley JA, Prendergast AJ(2016). Immune Dysfunction as a Cause and Consequence of Malnutrition. Trends in Immunology vol. 37, (6) Article TREIMM_1280, 386-398.

Sanin DE, Prendergast CT, Bourke CD, Mountford AP(2015). Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive. PLOS Pathogens vol. 11, (5) e1004841-e1004841.

Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ, Mountford AP(2015). Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection. Int J Parasitol vol. 45, (4) 215-224.

Fukushige M, Mitchell KM, Bourke CD, Woolhouse MEJ, Mutapi F(2015). A meta-analysis of experimental studies of attenuated Schistosoma mansoni vaccines in the mouse model. Frontiers in Immunology vol. 6, (FEB)

Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE et al.(2015). Down regulation of the TCR complex CD3ζ-chain on CD3+ T cells: A potential mechanism for helminth-mediated immune modulation. Frontiers in Immunology vol. 6, (FEB)

Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T, Mutapi F(2014). CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1. PLoS Neglected Tropical Diseases vol. 8, (8) e3049-e3049.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F(2014). Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment. PLoS Neglected Tropical Diseases vol. 8, (5) e2846-e2846.

Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP(2014). Circulating CD14brightCD16+ ‘Intermediate’ Monocytes Exhibit Enhanced Parasite Pattern Recognition in Human Helminth Infection. PLoS Neglected Tropical Diseases vol. 8, (4) e2817-e2817.

Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K et al.(2013). Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products. Parasite Immunology vol. 35, (5-6) 147-156.

Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE, Mutapi F(2012). Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children. PLoS Neglected Tropical Diseases vol. 6, (11) e1898-e1898.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F(2012). Integrated Analysis of Innate, Th1, Th2, Th17, and Regulatory Cytokines Identifies Changes in Immune Polarisation Following Treatment of Human Schistosomiasis. The Journal of Infectious Diseases vol. 208, (1) 159-169.

Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IYD, Appleby LJ, Bourke CD et al.(2012). Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection. PLoS Neglected Tropical Diseases vol. 6, (9) e1824-e1824.

Bourke CD, Mutapi F, Nausch N, Photiou DMF, Poulsen LK, Kristensen B, Arnved J, Rønborg S et al.(2012). Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response. Clinical & Experimental Allergy vol. 42, (11) 1582-1595.

Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T et al.(2012). Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium. Scientific Reports vol. 2, (1) Article 472,

Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW, Mutapi F(2012). Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of <i>Schistosoma haematobium</i> Infection. International Archives of Allergy and Immunology vol. 158, (3) 288-298.

Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP(2011). The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production. International Journal for Parasitology vol. 41, (13-14) 1335-1345.

IMAI N, RUJENI N, NAUSCH N, BOURKE CD, APPLEBY LJ, COWAN G, GWISAI R, MIDZI N et al.(2011). Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria. Parasitology vol. 138, (12) 1519-1533.

Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N, Mduluza T(2011). Schistosoma haematobium Treatment in 1–5 Year Old Children: Safety and Efficacy of the Antihelminthic Drug Praziquantel. PLoS Neglected Tropical Diseases vol. 5, (5) e1143-e1143.

Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse MEJ et al.(2011). Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels. PLoS ONE vol. 6, (5) e19149-e19149.

MUTAPI F, BOURKE C, HARCUS Y, MIDZI N, MDULUZA T, TURNER CM, BURCHMORE R, MAIZELS RM(2011). Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Parasite Immunology vol. 33, (3) 181-192.

BOURKE CD, MAIZELS RM, MUTAPI F(2010). Acquired immune heterogeneity and its sources in human helminth infection. Parasitology vol. 138, (2) 139-159.