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Publications:  Dr Claire Bourke

BOURKE CD, PRENDERGAST A, DEAYTON J, PARDIEU C, Naheed C(2019). Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation. Science Translational Medicine vol. 11,
10.1126/scitranslmed.aav0537
Sturgeon JP, Bourke CD, PRENDERGAST AJ(2019). Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses. The Pediatric Infectious Disease Journal1-1.
10.1097/inf.0000000000002311
BOURKE CD, PRENDERGAST A, ROBERTSON R(2019). Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study. BMJ Open
10.1136/bmjopen-2018-023077
Freer JB, Bourke CD, Durhuus GH, Kjetland EF, Prendergast AJ(2018). Schistosomiasis in the first 1000 days. Lancet Infect Dis vol. 18, (6) e193-e203.
10.1016/S1473-3099(17)30490-5
BOURKE CD, Berkley JA, Prendergast AJ(2016). Immune Dysfunction as a Cause and Consequence of Malnutrition. Trends in Immunology vol. 37, (6) Article TREIMM_1280, 386-398.
10.1016/j.it.2016.04.003
Sanin DE, Prendergast CT, Bourke CD, Mountford AP(2015). Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive. PLOS Pathogens vol. 11, (5) e1004841-e1004841.
10.1371/journal.ppat.1004841
Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ, Mountford AP(2015). Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection. Int J Parasitol vol. 45, (4) 215-224.
10.1016/j.ijpara.2014.11.002
Fukushige M, Mitchell KM, Bourke CD, Woolhouse MEJ, Mutapi F(2015). A meta-analysis of experimental studies of attenuated Schistosoma mansoni vaccines in the mouse model. Frontiers in Immunology vol. 6, (FEB)
10.3389/fimmu.2015.00085
Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE et al.(2015). Down regulation of the TCR complex CD3ζ-chain on CD3+ T cells: A potential mechanism for helminth-mediated immune modulation. Frontiers in Immunology vol. 6, (FEB)
10.3389/fimmu.2015.00051
Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T, Mutapi F(2014). CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1. PLoS Neglected Tropical Diseases vol. 8, (8) e3049-e3049.
10.1371/journal.pntd.0003049
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F(2014). Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment. PLoS Neglected Tropical Diseases vol. 8, (5) e2846-e2846.
10.1371/journal.pntd.0002846
Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP(2014). Circulating CD14brightCD16+ ‘Intermediate’ Monocytes Exhibit Enhanced Parasite Pattern Recognition in Human Helminth Infection. PLoS Neglected Tropical Diseases vol. 8, (4) e2817-e2817.
10.1371/journal.pntd.0002817
Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K et al.(2013). Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products. Parasite Immunology vol. 35, (5-6) 147-156.
10.1111/pim.12028
Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE, Mutapi F(2012). Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children. PLoS Neglected Tropical Diseases vol. 6, (11) e1898-e1898.
10.1371/journal.pntd.0001898
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F(2012). Integrated Analysis of Innate, Th1, Th2, Th17, and Regulatory Cytokines Identifies Changes in Immune Polarisation Following Treatment of Human Schistosomiasis. The Journal of Infectious Diseases vol. 208, (1) 159-169.
10.1093/infdis/jis524
Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IYD, Appleby LJ, Bourke CD et al.(2012). Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection. PLoS Neglected Tropical Diseases vol. 6, (9) e1824-e1824.
10.1371/journal.pntd.0001824
Bourke CD, Mutapi F, Nausch N, Photiou DMF, Poulsen LK, Kristensen B, Arnved J, Rønborg S et al.(2012). Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response. Clinical & Experimental Allergy vol. 42, (11) 1582-1595.
10.1111/j.1365-2222.2012.04063.x
Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T et al.(2012). Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium. Scientific Reports vol. 2, (1) Article 472,
10.1038/srep00472
Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW, Mutapi F(2012). Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of <i>Schistosoma haematobium</i> Infection. International Archives of Allergy and Immunology vol. 158, (3) 288-298.
10.1159/000332949
Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP(2011). The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production. International Journal for Parasitology vol. 41, (13-14) 1335-1345.
10.1016/j.ijpara.2011.08.005
IMAI N, RUJENI N, NAUSCH N, BOURKE CD, APPLEBY LJ, COWAN G, GWISAI R, MIDZI N et al.(2011). Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria. Parasitology vol. 138, (12) 1519-1533.
10.1017/s0031182011001181
Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N, Mduluza T(2011). Schistosoma haematobium Treatment in 1–5 Year Old Children: Safety and Efficacy of the Antihelminthic Drug Praziquantel. PLoS Neglected Tropical Diseases vol. 5, (5) e1143-e1143.
10.1371/journal.pntd.0001143
Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse MEJ et al.(2011). Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels. PLoS ONE vol. 6, (5) e19149-e19149.
10.1371/journal.pone.0019149
BOURKE CD, MAIZELS RM, MUTAPI F(2010). Acquired immune heterogeneity and its sources in human helminth infection. Parasitology vol. 138, (2) 139-159.
10.1017/s0031182010001216
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