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Publications:  Dr Sian Henson

Mahler C, Andrews M, Henson S, Gnanapavan S(2020). Sequential Interleukin 2 and Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy. Neurology, Neuroimmunology and Neuroinflammation
Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S et al.(2020). Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. Journal of Neuroinflammation
Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers E et al.(2020). Sestrins induce natural killer function in 1 senescent-like CD8+ T cells. Nature Immunology
Callender L, Carroll E, BOBER E, Akbar A, Solito E, Henson S(2019). Mitochondrial mass governs the extent of human T cell senescence. Aging Cell vol. 19, (2)
Gadsbøll A-SØ, Jee MH, Funch AB, Alhede M, Mraz V, Weber JF, Callender LA, Carroll EC et al.(2019). Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis. Journal of Investigative Dermatology
Lau EYM, Carroll EC, Callender LA, Hood GA, Berryman V, Pattrick M, Finer S, Hitman GA et al.(2019). Type 2 diabetes is associated with the accumulation of senescent T cells. Clinical & Experimental Immunology
Callender LA, Carroll EC, Bober EA, Henson SM(2018). Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescence. Ageing Research Reviews vol. 47, 24-30.
Seidel JA, Vukmanovic-Stejic M, Muller-Durovic B, Patel N, Fuentes-Duculan J, Henson SM, Krueger JG, Rustin MHA et al.(2018). Skin resident memory CD8<sup>+</sup>T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function. Clinical and Experimental Immunology vol. 194, (1) 79-92.
Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN, Henson SM(2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK. Aging Cell
HENSON SM, Akbar AN, Lanna A(2016). Senescence of T Lymphocytes: Implications for Enhancing Human Immunity. Trends in Immunology
Vukmanovic-Stejic M, Seidel JA, Patel N, Henson SH, Rustin MH, Nestle FO, Lacy K, Akbar AN (2016). Skin resident CD8+T-cells display low cytotoxic potential in healthy skin and fail to fully mature in primary melanoma lesions. BRITISH JOURNAL OF DERMATOLOGY. vol. 175, 64-65.
Müller-Durovic B, Lanna A, Polaco Covre L, Mills RS, Henson SM, Akbar AN(2016). Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase. Journal of Immunology vol. 197, (7) 2891-2899.
Schurich A, Pallett LJ, Jajbhay D, Wijngaarden J, Otano I, GIll US, Hansi N, Kennedy PT et al.(2016). Distinct metabolic requirements of exhausted and functional virus-specific CD8 T cells in the same host. Cell Reports vol. 16, (5) 1243-1252.
Henson SM(2015). CD8+ T-cell senescence: no role for mTOR. Biochem Soc Trans vol. 43, (4) 734-739.
Veliça P, Zech M, Henson S, Holler A, Manzo T, Pike R, Santos E Sousa P, Zhang L et al.(2015). Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation. Cancer Res vol. 75, (13) 2641-2652.
Riddell NE, Griffiths SJ, Rivino L, King DCB, Teo GH, Henson SM, Cantisan S, Solana R et al.(2015). Multifunctional cytomegalovirus (CMV)-specific CD8+ T cells are not restricted by telomere-related senescence in young or old adults. Immunology vol. 144, (4) Article 4, 549-560.
Henson SM, Macaulay R, Riddell NE, Nunn CJ, Akbar AN(2015). Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8+ T-cell proliferation by distinct pathways. European Journal of Immunology vol. 45, Article 5, 1441-1451.
Seidel JA, Henson SM, Riddell N, Vukmanovic-Stejic M, Rustin MH, Nestle FO, Lacy K, Akbar AN(2014). Skin resident CD8(+) T-cells display low cytotoxic potential in healthy skin and fail to fully mature in primary melanoma lesions. IMMUNOLOGY vol. 143, 52-52.
Henson SM, Akbar AN(2014). mTOR-independent regulation of senescent human CD8(+) T-cells. IMMUNOLOGY vol. 143, 49-49.
Schurich A, Henson SM(2014). The many unknowns concerning the bioenergetics of exhaustion and senescence during chronic viral infection. Frontiers in Immunology vol. 5, Article 468,
Henson SM, Lanna A, Riddell NE, Franzese O, Macaulay R, Griffiths SJ, Puleston DJ, Watson AS et al.(2014). p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells. J Clin Invest vol. 124, (9) 4004-4016.
Lanna A, Henson SM, Escors D, Akbar AN(2014). The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol vol. 15, (10) 965-972.
Franzese O, Henson SM, Naro C, Bonmassar E(2014). Defect in HSP90 expression in highly differentiated human CD8+ T lymphocytes. Cell Death Dis vol. 5,
Lanna A, Coutavas E, Levati L, Seidel J, Rustin MHA, Henson SM, Akbar AN, Franzese O(2013). IFN-α Inhibits Telomerase in Human CD8+ T Cells by Both hTERT Downregulation and Induction of p38 MAPK Signaling. The Journal of Immunology vol. 191, (7) 3744-3752.
Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S et al.(2013). Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA. The Journal of Immunology vol. 190, (11) 5363-5372.
Seidel JA, Riddell N, Henson S, Vukmanovic-Stejic M, Rustin M, Nestle F, Lacy K, Akbar A (2013). Global circulating CD4+and CD8+T cells are more differentiated in old melanoma patients compared to healthy controls. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S14-S14.
Macaulay R, Riddell NE, Griffiths SJ, Akbar AN, Henson SM(2013). Differing HLA types influence inhibitory receptor signalling in CMV-specific CD8+ T cells. Human Immunology vol. 74, (3) 302-309.
Macaulay R, Akbar AN, Henson SM(2013). The role of the T cell in age-related inflammation. AGE vol. 35, Article 3, 563-572.
Havenith SHC, Yong SL, Henson SM, Piet B, Idu MM, Koch SD, Jonkers RE, Kragten NAM et al.(2012). Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells. International Immunology vol. 24, (10) 625-636.
Seidel JA, Riddell N, Henson S, Vukmanovic-Stejic M, Rustin M, Nestle F, Lacy KE, Akbar AN (2012). Increased CD4+and CD8+T cell differentiation in old melanoma patients. IMMUNOLOGY. vol. 137, 611-611.
Henson SM, Riddell NE, Akbar AN(2012). Properties of end-stage human T cells defined by CD45RA re-expression. Curr Opin Immunol vol. 24, (4) 476-481.
Seidel J, Riddell N, Henson S, Vukmanovic-Stejic M, Rustin M, Nestle F, Lacy K, Akbar A (2012). Increased CD4 and CD8 T-cell differentiation in elderly patients with melanoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 166, e35-e36.
Henson SM, Macaulay R, Franzese O, Akbar AN(2012). Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade. Immunology vol. 135, (4) 355-363.
Henson SM, Franzese O, Macaulay R, Akbar AN (2011). PD-1 acting through AKT mediates a proliferative defect in highly differentiated CD8+T cells. IMMUNOLOGY. vol. 135, 43-43.
Seidel JA, Riddell N, Henson S, Vukmanovic-Stejic M, Lacy K, Rustin M, Akbar A (2011). Peripheral T cell activation and differentiation in elderly melanoma patients. IMMUNOLOGY. vol. 135, 83-83.
Di Mitri D, Henson S, Riddell NE, Kipling D, Soares MVD, Battistini L, Akbar AN (2011). Reversible senescence in human CD4(+) CD45RA(+)CD27(-) memory T cells. IMMUNOLOGY. vol. 135, 72-72.
Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C et al.(2011). Report from the second cytomegalovirus and immunosenescence workshop. Immunity & Ageing vol. 8, Article 1, 1-8.
Di Mitri D, Azevedo RI, Henson SM, Libri V, Riddell NE, Macaulay R, Kipling D, Soares MVD et al.(2011). Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells. The Journal of Immunology vol. 187, (5) 2093-2100.
Akbar AN, Henson SM(2011). Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?. Nat Rev Immunol vol. 11, (4) 289-295.
Wallace DL, Masters JE, De Lara CM, Henson SM, Worth A, Zhang Y, Kumar SR, Beverley PC et al.(2011). Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects. Immunology vol. 132,
van de Berg PJEJ, Griffiths SJ, Yong S, Macaulay R, Bemelman FJ, Jackson S, Henson SM, ten Berge IJM et al.(2010). Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool. The Journal of Immunology vol. 184, (7) 3417-3423.
Henson SM, Akbar AN(2010). Memory T-cell homeostasis and senescence during aging. Adv Exp Med Biol vol. 684, 189-197.
Henson SM, Akbar AN(2009). KLRG1--more than a marker for T cell senescence. Age (Dordr) vol. 31, (4) 285-291.
Henson SM, Franzese O, Macaulay R, Libri V, Azevedo RI, Kiani-Alikhan S, Plunkett FJ, Masters JE et al.(2009). KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells. Blood vol. 113, (26) 6619-6628.
Henson SM, Macaulay R, Kiani-Alikhan S, Akbar AN(2008). The use of the inhibitory receptors for modulating the immune responses. Current Pharmaceutical Design vol. 14, (26) 2643-2650.
Aspinall R, Pido-Lopez J, Imami N, Henson SM, Ngom PT, Morre M, Niphuis H, Remarque E et al.(2007). Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination. Rejuvenation Research vol. 10, (1) 5-17.
Ghattas H, Wallace DL, Solon JA, Henson SM, Zhang Y, Ngom PT, Aspinall R, Morgan G et al.(2007). Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men. American Journal of Clinical Nutrition vol. 85, (2) 480-487.
Henson SM, Snelgrove R, Hussell T, Wells DJ, Aspinall R(2005). An IL-7 fusion protein that shows increased thymopoietic ability. Journal of Immunology vol. 175, (6) 4112-4118.
Herndler-Brandstetter D, Schwaiger S, Veel E, Fehrer C, Cioca DP, Almanzar G, Keller M, Pfister G et al.(2005). CD25-expressing CD8<sup>+</sup> T cells are potent memory cells in old age. Journal of Immunology vol. 175, (3) 1566-1574.
Ngom PT, Collinson AC, Pido-Lopez J, Henson SM, Prentice AM, Aspinall R(2004). Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk. American Journal of Clinical Nutrition vol. 80, (3) 722-728.
Henson SM, Pido-Lopez J, Aspinall R (2004). Reversal of thymic atrophy. Experimental Gerontology. vol. 39, 673-678.
Aspinall R, Henson S, Pido-Lopez J, Ngom PT(2004). Interleukin-7: An interleukin for rejuvenating the immune system. Annals of the New York Academy of Sciences vol. 1019, 116-122.
Aspinall R, Henson SM, Pido-Lopez J(2003). My T's gone cold, I'm wondering why. Nat Immunol vol. 4, (3) 203-205.
Russell WS, Henson SM, Hussein AS, Tippins JR, Selkirk ME(2000). Nippostrongylus brasiliensis: Infection Induces Upregulation of Acetylcholinesterase Activity on Rat Intestinal Epithelial Cells. Experimental Parasitology vol. 96, (4) 222-230.
Sennitt MV, Kaumann AJ, Molenaar P, Beeley LJ, Young PW, Kelly J, Chapman H, Henson SM et al.(1998). The Contribution of Classical (β1/2-) and Atypical β-Adrenoceptors to the Stimulation of Human White Adipocyte Lipolysis and Right Atrial Appendage Contraction by Novel β3-Adrenoceptor Agonists of Differing Selectivities. Journal of Pharmacology and Experimental Therapeutics vol. 285, (3) 1084-1095.
Molenaar P, Sarsero D, Arch JRS, Kelly J, Henson SM, Kaumann AJ(1997). Effects of (−)-RO363 at human atrial β-adrenoceptor subtypes, the human cloned β3-adrenoceptor and rodent intestinal β3-adrenoceptors. British Journal of Pharmacology vol. 120, (2) 165-176.
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