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Publications:  Dr Sian Henson

Mahler C, Andrews M, Henson S, Gnanapavan S(2020). Sequential Interleukin 2 and Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy. Neurology, Neuroimmunology and Neuroinflammation
10.1212/NXI.0000000000000756
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65645
Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S et al.(2020). Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. Journal of Neuroinflammation
10.1186/s12974-020-01810-8
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64712
Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers E et al.(2020). Sestrins induce natural killer function in 1 senescent-like CD8+ T cells. Nature Immunology
10.1038/s41590-020-0643-3
Callender L, Carroll E, BOBER E, Akbar A, Solito E, Henson S(2019). Mitochondrial mass governs the extent of human T cell senescence. Aging Cell vol. 19, (2)
10.1111/acel.13067
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63820
Gadsbøll A-SØ, Jee MH, Funch AB, Alhede M, Mraz V, Weber JF, Callender LA, Carroll EC et al.(2019). Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis. Journal of Investigative Dermatology
10.1016/j.jid.2019.07.722
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59502
Lau EYM, Carroll EC, Callender LA, Hood GA, Berryman V, Pattrick M, Finer S, Hitman GA et al.(2019). Type 2 diabetes is associated with the accumulation of senescent T cells. Clinical & Experimental Immunology
10.1111/cei.13344
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58984
Callender LA, Carroll EC, Bober EA, Henson SM(2018). Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescence. Ageing Research Reviews vol. 47, 24-30.
10.1016/j.arr.2018.06.001
https://qmro.qmul.ac.uk/xmlui/handle/123456789/41603
Seidel JA, Vukmanovic-Stejic M, Muller-Durovic B, Patel N, Fuentes-Duculan J, Henson SM, Krueger JG, Rustin MHA et al.(2018). Skin resident memory CD8<sup>+</sup>T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function. Clinical and Experimental Immunology vol. 194, (1) 79-92.
10.1111/cei.13189
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58479
Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN, Henson SM(2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK. Aging Cell
10.1111/acel.12675
https://qmro.qmul.ac.uk/xmlui/handle/123456789/26363
HENSON SM, Akbar AN, Lanna A(2016). Senescence of T Lymphocytes: Implications for Enhancing Human Immunity. Trends in Immunology
10.1016/j.it.2016.09.002
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15905
Vukmanovic-Stejic M, Seidel JA, Patel N, Henson SH, Rustin MH, Nestle FO, Lacy K, Akbar AN (2016). Skin resident CD8+T-cells display low cytotoxic potential in healthy skin and fail to fully mature in primary melanoma lesions. BRITISH JOURNAL OF DERMATOLOGY. vol. 175, 64-65.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/17442
Müller-Durovic B, Lanna A, Polaco Covre L, Mills RS, Henson SM, Akbar AN(2016). Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase. Journal of Immunology vol. 197, (7) 2891-2899.
10.4049/jimmunol.1600590
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15387
Schurich A, Pallett LJ, Jajbhay D, Wijngaarden J, Otano I, GIll US, Hansi N, Kennedy PT et al.(2016). Distinct metabolic requirements of exhausted and functional virus-specific CD8 T cells in the same host. Cell Reports vol. 16, (5) 1243-1252.
10.1016/j.celrep.2016.06.078
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13465
Henson SM(2015). CD8+ T-cell senescence: no role for mTOR. Biochem Soc Trans vol. 43, (4) 734-739.
10.1042/BST20150092
Veliça P, Zech M, Henson S, Holler A, Manzo T, Pike R, Santos E Sousa P, Zhang L et al.(2015). Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation. Cancer Res vol. 75, (13) 2641-2652.
10.1158/0008-5472.CAN-14-3283
Riddell NE, Griffiths SJ, Rivino L, King DCB, Teo GH, Henson SM, Cantisan S, Solana R et al.(2015). Multifunctional cytomegalovirus (CMV)-specific CD8+ T cells are not restricted by telomere-related senescence in young or old adults. Immunology vol. 144, (4) Article 4, 549-560.
10.1111/imm.12409
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15829
Henson SM, Macaulay R, Riddell NE, Nunn CJ, Akbar AN(2015). Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8+ T-cell proliferation by distinct pathways. European Journal of Immunology vol. 45, Article 5, 1441-1451.
10.1002/eji.201445312
Seidel JA, Henson SM, Riddell N, Vukmanovic-Stejic M, Rustin MH, Nestle FO, Lacy K, Akbar AN(2014). Skin resident CD8(+) T-cells display low cytotoxic potential in healthy skin and fail to fully mature in primary melanoma lesions. IMMUNOLOGY vol. 143, 52-52.
Henson SM, Akbar AN(2014). mTOR-independent regulation of senescent human CD8(+) T-cells. IMMUNOLOGY vol. 143, 49-49.
Schurich A, Henson SM(2014). The many unknowns concerning the bioenergetics of exhaustion and senescence during chronic viral infection. Frontiers in Immunology vol. 5, Article 468,
10.3389/fimmu.2014.00468
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15828
Henson SM, Lanna A, Riddell NE, Franzese O, Macaulay R, Griffiths SJ, Puleston DJ, Watson AS et al.(2014). p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells. J Clin Invest vol. 124, (9) 4004-4016.
10.1172/JCI75051
Lanna A, Henson SM, Escors D, Akbar AN(2014). The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol vol. 15, (10) 965-972.
10.1038/ni.2981
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15827
Franzese O, Henson SM, Naro C, Bonmassar E(2014). Defect in HSP90 expression in highly differentiated human CD8+ T lymphocytes. Cell Death Dis vol. 5,
10.1038/cddis.2014.259
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15262
Lanna A, Coutavas E, Levati L, Seidel J, Rustin MHA, Henson SM, Akbar AN, Franzese O(2013). IFN-α Inhibits Telomerase in Human CD8+ T Cells by Both hTERT Downregulation and Induction of p38 MAPK Signaling. The Journal of Immunology vol. 191, (7) 3744-3752.
10.4049/jimmunol.1301409
Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S et al.(2013). Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA. The Journal of Immunology vol. 190, (11) 5363-5372.
10.4049/jimmunol.1203267
Seidel JA, Riddell N, Henson S, Vukmanovic-Stejic M, Rustin M, Nestle F, Lacy K, Akbar A (2013). Global circulating CD4+and CD8+T cells are more differentiated in old melanoma patients compared to healthy controls. JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 133, S14-S14.
Macaulay R, Riddell NE, Griffiths SJ, Akbar AN, Henson SM(2013). Differing HLA types influence inhibitory receptor signalling in CMV-specific CD8+ T cells. Human Immunology vol. 74, (3) 302-309.
10.1016/j.humimm.2012.11.014
Macaulay R, Akbar AN, Henson SM(2013). The role of the T cell in age-related inflammation. AGE vol. 35, Article 3, 563-572.
10.1007/s11357-012-9381-2
Havenith SHC, Yong SL, Henson SM, Piet B, Idu MM, Koch SD, Jonkers RE, Kragten NAM et al.(2012). Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells. International Immunology vol. 24, (10) 625-636.
10.1093/intimm/dxs069
Seidel JA, Riddell N, Henson S, Vukmanovic-Stejic M, Rustin M, Nestle F, Lacy KE, Akbar AN (2012). Increased CD4+and CD8+T cell differentiation in old melanoma patients. IMMUNOLOGY. vol. 137, 611-611.
Henson SM, Riddell NE, Akbar AN(2012). Properties of end-stage human T cells defined by CD45RA re-expression. Curr Opin Immunol vol. 24, (4) 476-481.
10.1016/j.coi.2012.04.001
Seidel J, Riddell N, Henson S, Vukmanovic-Stejic M, Rustin M, Nestle F, Lacy K, Akbar A (2012). Increased CD4 and CD8 T-cell differentiation in elderly patients with melanoma. BRITISH JOURNAL OF DERMATOLOGY. vol. 166, e35-e36.
Henson SM, Macaulay R, Franzese O, Akbar AN(2012). Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade. Immunology vol. 135, (4) 355-363.
10.1111/j.1365-2567.2011.03550.x
Henson SM, Franzese O, Macaulay R, Akbar AN (2011). PD-1 acting through AKT mediates a proliferative defect in highly differentiated CD8+T cells. IMMUNOLOGY. vol. 135, 43-43.
Seidel JA, Riddell N, Henson S, Vukmanovic-Stejic M, Lacy K, Rustin M, Akbar A (2011). Peripheral T cell activation and differentiation in elderly melanoma patients. IMMUNOLOGY. vol. 135, 83-83.
Di Mitri D, Henson S, Riddell NE, Kipling D, Soares MVD, Battistini L, Akbar AN (2011). Reversible senescence in human CD4(+) CD45RA(+)CD27(-) memory T cells. IMMUNOLOGY. vol. 135, 72-72.
Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C et al.(2011). Report from the second cytomegalovirus and immunosenescence workshop. Immunity & Ageing vol. 8, Article 1, 1-8.
10.1186/1742-4933-8-10
https://qmro.qmul.ac.uk/xmlui/handle/123456789/15830
Di Mitri D, Azevedo RI, Henson SM, Libri V, Riddell NE, Macaulay R, Kipling D, Soares MVD et al.(2011). Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells. The Journal of Immunology vol. 187, (5) 2093-2100.
10.4049/jimmunol.1100978
Akbar AN, Henson SM(2011). Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?. Nat Rev Immunol vol. 11, (4) 289-295.
10.1038/nri2959
Wallace DL, Masters JE, De Lara CM, Henson SM, Worth A, Zhang Y, Kumar SR, Beverley PC et al.(2011). Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects. Immunology vol. 132,
10.1111/j.1365-2567.2010.03334.x
van de Berg PJEJ, Griffiths SJ, Yong S, Macaulay R, Bemelman FJ, Jackson S, Henson SM, ten Berge IJM et al.(2010). Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool. The Journal of Immunology vol. 184, (7) 3417-3423.
10.4049/jimmunol.0903442
Henson SM, Akbar AN(2010). Memory T-cell homeostasis and senescence during aging. Adv Exp Med Biol vol. 684, 189-197.
10.1007/978-1-4419-6451-9_15
Henson SM, Akbar AN(2009). KLRG1--more than a marker for T cell senescence. Age (Dordr) vol. 31, (4) 285-291.
10.1007/s11357-009-9100-9
Henson SM, Franzese O, Macaulay R, Libri V, Azevedo RI, Kiani-Alikhan S, Plunkett FJ, Masters JE et al.(2009). KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells. Blood vol. 113, (26) 6619-6628.
10.1182/blood-2009-01-199588
Henson SM, Macaulay R, Kiani-Alikhan S, Akbar AN(2008). The use of the inhibitory receptors for modulating the immune responses. Current Pharmaceutical Design vol. 14, (26) 2643-2650.
10.2174/138161208786264124
Aspinall R, Pido-Lopez J, Imami N, Henson SM, Ngom PT, Morre M, Niphuis H, Remarque E et al.(2007). Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination. Rejuvenation Research vol. 10, (1) 5-17.
10.1089/rej.2006.9098
Ghattas H, Wallace DL, Solon JA, Henson SM, Zhang Y, Ngom PT, Aspinall R, Morgan G et al.(2007). Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men. American Journal of Clinical Nutrition vol. 85, (2) 480-487.
10.1093/ajcn/85.2.480
Henson SM, Snelgrove R, Hussell T, Wells DJ, Aspinall R(2005). An IL-7 fusion protein that shows increased thymopoietic ability. Journal of Immunology vol. 175, (6) 4112-4118.
10.4049/jimmunol.175.6.4112
Herndler-Brandstetter D, Schwaiger S, Veel E, Fehrer C, Cioca DP, Almanzar G, Keller M, Pfister G et al.(2005). CD25-expressing CD8<sup>+</sup> T cells are potent memory cells in old age. Journal of Immunology vol. 175, (3) 1566-1574.
10.4049/jimmunol.175.3.1566
Ngom PT, Collinson AC, Pido-Lopez J, Henson SM, Prentice AM, Aspinall R(2004). Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk. American Journal of Clinical Nutrition vol. 80, (3) 722-728.
10.1093/ajcn/80.3.722
Henson SM, Pido-Lopez J, Aspinall R (2004). Reversal of thymic atrophy. Experimental Gerontology. vol. 39, 673-678.
10.1016/j.exger.2003.10.030
Aspinall R, Henson S, Pido-Lopez J, Ngom PT(2004). Interleukin-7: An interleukin for rejuvenating the immune system. Annals of the New York Academy of Sciences vol. 1019, 116-122.
10.1196/annals.1297.021
Aspinall R, Henson SM, Pido-Lopez J(2003). My T's gone cold, I'm wondering why. Nat Immunol vol. 4, (3) 203-205.
10.1038/ni0303-203
Russell WS, Henson SM, Hussein AS, Tippins JR, Selkirk ME(2000). Nippostrongylus brasiliensis: Infection Induces Upregulation of Acetylcholinesterase Activity on Rat Intestinal Epithelial Cells. Experimental Parasitology vol. 96, (4) 222-230.
10.1006/expr.2000.4565
Sennitt MV, Kaumann AJ, Molenaar P, Beeley LJ, Young PW, Kelly J, Chapman H, Henson SM et al.(1998). The Contribution of Classical (β1/2-) and Atypical β-Adrenoceptors to the Stimulation of Human White Adipocyte Lipolysis and Right Atrial Appendage Contraction by Novel β3-Adrenoceptor Agonists of Differing Selectivities. Journal of Pharmacology and Experimental Therapeutics vol. 285, (3) 1084-1095.
Molenaar P, Sarsero D, Arch JRS, Kelly J, Henson SM, Kaumann AJ(1997). Effects of (−)-RO363 at human atrial β-adrenoceptor subtypes, the human cloned β3-adrenoceptor and rodent intestinal β3-adrenoceptors. British Journal of Pharmacology vol. 120, (2) 165-176.
10.1038/sj.bjp.0700850
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