Publications:  Dr Nimesh Patel

Bangash MN, Abbott TEF, Patel NSA, Hinds C, Thiemermann C, Pearse R(2020). The Effect of β2-Adrenoceptor Agonists on Leucocyte-Endothelial Adhesion in a Rodent Model of Laparotomy and Endotoxemia. Frontiers in Immunology vol. 11,

VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C et al.(2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Journal of Pathology vol. 248, (1) 88-102.

Blondeau B, Orlando A, Jarvis S, Banton K, Berg GM, Patel N, Meinig R, Tanner A et al.(2019). Variability in pelvic packing practices for hemodynamically unstable pelvic fractures at US level 1 trauma centers. Patient Safety in Surgery vol. 13, (1)

Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA et al.(2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg vol. 265, (2) 408-417.

Yuzugulen J, Douthwaite JA, Wood EG, Villar IC, Patel NSA, Jegard J, Gaertner H, Rossitto-Borlat I et al.(2017). Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1. Sci Rep vol. 7, (1) 4956-4956.

Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV et al.(2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis. J Am Heart Assoc vol. 6, (7)

Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N et al.(2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. Journal of the American Society of Nephrology

Madalli S, Beyrau M, Whiteford J, Duchene J, Nandhra IS, Patel NSA, Motwani MP, Gilroy DW et al.(2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. Biology of Sex Differences vol. 6, (1)

Chen J, Kieswich J, Chiazza F, Gobbetti T, Patel NSA, Perretti M, Collino M, Yaqoob MM et al. (2015). THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE. SHOCK. vol. 44, 16-16.

Johnson F, Patel N, Collino M, Bennetti E, Thiemermann C (2015). THE LATE INHIBITION OF INHIBITOR OF IKB KINASE ATTENUATES ACUTE KIDNEY INJURY AND THE SUBSEQUENT DEVELOPMENT OF FIBROSIS IN A RAT MODEL OF ISCHAEMIA REPERFUSION INJURY. SHOCK. vol. 44, 10-10.

Sordi R, Nandra KK, Chiazza F, Patel NSA, Brohi K, Collino M, Thiemermann C (2015). TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT. SHOCK. vol. 44, 1-1.

Sordi R, Chiazza F, Johnson FL, Patel NSA, Brohi K, Collino M, Thiemermann C(2015). Inhibition of IκB kinase attenuates the organ injury and dysfunction associated with hemorrhagic shock. Molecular Medicine vol. 21, 563-575.

Sordi R, Chiazza F, Patel NSA, Doyle RA, Collino M, Thiemermann C(2015). 'Preconditioning' with low dose lipopolysaccharide aggravates the organ injury/dysfunction caused by hemorrhagic shock in rats. PLoS ONE vol. 10, (4)

Chen J, Chiazza F, Collino M, Patel NSA, Coldewey SM, Thiemermann C(2014). Gender dimorphism of the cardiac dysfunction in murine sepsis: Signalling mechanisms and age-dependency. PLoS ONE vol. 9, (6)

Benetti E, Chiazza F, Patel NSA, Collino M(2013). The NLRP3 inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. Mediators of Inflammation vol. 2013,

Khan AI, Coldewey SM, Patel NSA, Rogazzo M, Collino M, Yaqoob MM, Radermacher P, Kapoor A et al. (2013). Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor. DMM Disease Models and Mechanisms. vol. 6, 1021-1030.

Coldewey SM, Rogazzo M, Collino M, Patel NSA, Thiemermann C(2013). Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. DMM Disease Models and Mechanisms vol. 6, (4) 1031-1042.

Nandra KK, Collino M, Rogazzo M, Fantozzi R, Patel NSA, Thiemermann C(2013). Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock. DMM Disease Models and Mechanisms vol. 6, (3) 701-709.

Bangash MN, Patel NSA, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM(2013). Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow. Critical Care vol. 17, (2)

Coldewey SM, Khan AI, Kapoor A, Collino M, Rogazzo M, Brines M, Cerami A, Hall P et al.(2013). Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Kidney International vol. 84, (3) 482-490.

Yuzugulen J, Wood EG, Douthwaite JA, Villar IC, Patel NS, Jegard J, Montoya A, Cutillas P et al.(2012). Characterization of Proendothelin-1 Derived Peptides Identifies a Co-secreted Modulator of ET-1 Vasoconstriction, and Provides Insights for Biomarker Measurements. CIRCULATION vol. 126, (21)

Patel NSA, Nandra KK, Thiemermann C(2012). Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care. Critical Care vol. 16, (4)

Nandra KK, Takahashi K, Collino M, Benetti E, Fred Wong WS, Goh FY, Suzuki K, Patel NSA et al.(2012). Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat. Shock vol. 37, (6) 592-598.

Patel NSA, Kerr-Peterson HL, Brines M, Collino M, Rogazzo M, Fantozzi R, Wood EG, Johnson FL et al.(2012). Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury. Molecular medicine (Cambridge, Mass.) vol. 18, 719-727.

Maio R, Sepodes B, Patel NSA, Thiemermann C, Mota-Filipe H, Costa P(2011). Erythropoietin preserves the integrity and quality of organs for transplantation after cardiac death. Shock vol. 35, (2) 126-133.

Patel NSA, Nandra KK, Brines M, Collino M, Wong WF, Kapoor A, Benetti E, Goh FY et al.(2011). A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock. Molecular medicine (Cambridge, Mass.) vol. 17, (9-10) 883-892.

Patel NSA, Collino M, Yaqoob MM, Thiemermann C(2011). Erythropoietin in the intensive care unit: Beyond treatment of anemia. Annals of Intensive Care vol. 1, (1)

Benetti E, Patel NSA, Collino M(2011). The role of PPARβ/δ in the management of metabolic syndrome and its associated cardiovascular complications. Endocrine, Metabolic and Immune Disorders - Drug Targets vol. 11, (4) 273-284.

Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NSA, Sepodes B, Castiglia S et al.(2010). Protective role of peroxisome proliferator-activated receptor-β/ δ in septic shock. American Journal of Respiratory and Critical Care Medicine vol. 182, (12) 1506-1515.

Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ et al. (2010). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. Nitric Oxide - Biology and Chemistry. vol. 22, 141-148.

Kumar S, Allen DA, Kieswich JE, Patel NSA, Harwood S, Mazzon E, Cuzzocrea S, Raftery MJ et al.(2009). Dexamethasone ameliorates renal ischemia-reperfusion injury. Journal of the American Society of Nephrology vol. 20, (11) 2412-2425.

Scheiermann C, Colom B, Meda P, Patel NSA, Voisin MB, Marrelli A, Woodfin A, Pitzalis C et al.(2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arteriosclerosis, Thrombosis, and Vascular Biology vol. 29, (10) 1509-1515.

Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H, Perretti M et al.(2009). Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: An in vivo study. European Journal of Pharmacology vol. 606, (1-3) 205-209.

Patel NSA, Di Paola R, Mazzon E, Britti D, Thiemermann C, Cuzzocrea S(2009). Peroxisome proliferator-activated receptor-α contributes to the resolution of inflammation after renal ischemia/reperfusion injury. Journal of Pharmacology and Experimental Therapeutics vol. 328, (2) 635-643.

Dugo L, Collin M, Allen DA, Patel NSA, Bauer I, Mervaala EMA, Louhelainen M, Foster SJ et al.(2008). Inhibiting Glycogen Synthase Kinase 3β in Sepsis. Sepsis: New Insights, New Therapies, vol. 280,

Tripatara P, Patel NSA, Collino M, Gallicchio M, Kieswich J, Castiglia S, Benetti E, Stewart KN et al.(2008). Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction. Laboratory Investigation vol. 88, (10) 1038-1048.

Brines M, Patel NSA, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S et al.(2008). Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America vol. 105, (31) 10925-10930.

Collino M, Patel NSA, Thiemermann C(2008). PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury. Therapeutic Advances in Cardiovascular Disease vol. 2, (3) 179-197.

Dugo L, Collin M, Allen DA, Patel NSA, Bauer I, Mervaala EMA, Louhelainen M, Foster SJ et al.(2007). Inhibiting glycogen synthase kinase 3β in sepsis. Novartis Foundation Symposium vol. 280, 128-142.

Patel NSA, Cuzzocrea S, Collino M, Chaterjee PK, Mazzon E, Britti D, Yaqoob MM, Thiemermann C(2007). The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo. European Journal of Pharmacology vol. 562, (1-2) 148-154.

Tripatara P, Patel NSA, Webb A, Rathod K, Lecomte FMJ, Mazzon E, Cuzzocrea S, Yaqoob MM et al.(2007). Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: Role for xanthine oxidoreductase. Journal of the American Society of Nephrology vol. 18, (2) 570-580.

THIEMERMANN C, Patel NS, Di Paola R, Mazzon E, Caputi AP, Crisafulli C, Muia C, Genovese T et al.(2006). Erythropoietin reduces the development of non-septic shock induced by zymosan in mice. Crit care Med vol. 34, (4) 1168-1177.

Dugo L, Collin M, Allen DA, Patel NS, Bauer I, Mervaala EM, Louhelainen M, Foster SJ et al.(2005). GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. Crit Care Med vol. 33, (9) 1903-1912.

THIEMERMANN C, Wang ZQ, Cuzzocrea S, Mota-Filipe H, Patel NS, Cortes U, Di Paola R, Mazzon E(2005). Mice Lacking the 110-kD Isoform of Poly(ADP-Ribose) Glycohydrolase Are Protected against Renal Ischemia/Reperfusion Injury. Journal of the American Society of Nephrology vol. 16, (3) 712-719.

Abdelrahman M, Mazzon E, Bauer M, Bauer I, Delbosc S, Cristol JP, Patel NSA, Cuzzocrea S et al. (2005). Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shock. Shock. vol. 23, 107-114.

THIEMERMANN C, Patel NS, Di Paola R, De Sarro A, Cuzzocrea S, Mazzon E, Muia C, Genovese T(2005). Beneficial effects of GW274150 treatment on the development of experimental colitis induced by dinitrobenzene sulfonic acid. Eur J Pharmacol vol. 507, (1-3) 281-289.

THIEMERMANN C, Mazzon E, Britti D, De Sarro A, Cuzzocrea S, Patel NS, Chatterjee PK, Di Paola R(2005). Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharmacol Exp Ther vol. 312, (3) 1170-1178.

THIEMERMANN C, Caputi AP, De Majo M, Patel NS, Britti D, Genovese T, Cuzzocrea S, Mazzon E et al.(2005). Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse. Arthritis Rheum vol. 52, (3) 940-950.

THIEMERMANN C, Genovese T, Cuzzocrea S, Bramanti P, De Sarro A, Threadgill MD, Mazzon E, Muia C et al.(2005). Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. J Pharmacol Exp Ther vol. 312, (2) 449-457.

THIEMERMANN C, Latchman DS, Collin M, Lawrence KM, Patel NS, Collino M, Yaqoob MM(2005). The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int vol. 68, (2) 529-536.

THIEMERMANN C, De Sarro A, Threadgill MD, Muia C, Mazzon E, Cuzzocrea S, Di Paola R, Genovese T et al.(2004). 5-Aminoisoquinolinone reduces colon injury by experimental colitis. Naunyn Schmiedebergs Arch Pharmacol vol. 498, (1-3) 295-301.

THIEMERMANN C, Patel NS, Chatterjee PK, Kvale EO, Stewart KN, Brown PA, Mota-Filipe H, Cuzzocrea S et al.(2004). EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney. American Journal of Nephrology vol. 24, 165-177.

THIEMERMANN C, Yaqoob MM, Raftery M, Harwood S, Allen D, Mota-Philipe H, Brown P, Sharples EJ et al.(2004). Erythropoietin Protects the Kidney against the Injury and Dysfunction Caused by Ischemia-Reperfusion. Journal American Society of Nephrology vol. 15, 2115-2124.

THIEMERMANN C, Yaqoob MM, McDonald MC, Patel NS, Collin M, Abdelrahman M, Sharples EJ(2004). Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia. Shock vol. 22, 63-69.

THIEMERMANN C, De Sarro A, Genovese T, Muia C, Di Paola R, Cuzzocrea S, Mazzon E, Patel NS(2004). Erythropoietin reduces the development of experimental inflammatory bowel disease. J Pharmacol Exp Ther vol. 311, (3) 1272-1280.

THIEMERMANN C, Cockerill GW, Patel NS, Dugo L, Genovese T, Di Paola R, Cuzzocrea S(2004). High-density lipoproteins reduce the intestinal damage associated with ischemia/reperfusion and colitis. Shock vol. 21, 342-351.

THIEMERMANN C, Wang ZQ, Filipe HM, Dugo L, Petrilli V, Herceg Z, Hassa PO, Patel NS et al.(2004). Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice. J Clin Invest vol. 114, (8) 1072-1081.

THIEMERMANN C, Yaqoob MM, Patel NS, Sharples EJ, Britti D, Chatterjee PK, Cuzzocrea S(2004). Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo. Kidney Int vol. 66, (3) 983-989.

THIEMERMANN C, Chatterjee PK, Patel NS, Britti D, Cuzzocrea S, Sautebin L, Di Paola R(2004). Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibotor zileuton. Molecular Pharmacology vol. 66, 220-227.

THIEMERMANN C, Rossi A, Collin M, Cuzzocrea S, Di Paola R, Hadley J, Patel NS, Sautebin L et al.(2004). Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. J Leukoc Biol vol. 76, (5) 961-970.

THIEMERMANN C, Patel NS, Dugo L, Collin M(2004). Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxy delta 12, 14 prostaglandin J2 against the multiple organ failure caused by endotoxin. Critical Care Medicine vol. 32, 826-831.

THIEMERMANN C, Chatterjee PK, Di Rosa M, Maffia P, Dugo L, Cuzzocrea S, Pisano B, Ianaro A et al.(2004). Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation. Eur J Pharmacol vol. 483, 79-93.

THIEMERMANN C, Patel NS, Dugo L, Caputi AP, Cuzzocrea S, Pisano B, Britti D, Di Rosa M et al.(2004). Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein. Intensive Care Medicine vol. 30, 951-956.

THIEMERMANN C, Patel NS, Dugo L, Caputi AP, Fulia F, Genovese T, Cuzzocrea S, Pisano B et al.(2004). Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces the development of nonseptic shock induced by zymosan in mice. Critical Care Medicine vol. 32, 457-466.

Dugo L, THIEMERMANN C, Patel NS, Pisano B, Caputi AP, Cuzzocrea S, Ianaro A(2004). Tempol reduces the activation of nuclear factor-kappaB in acute inflammation. Free Radic Res vol. 38, (8) 813-819.

THIEMERMANN C, Chatterjee PK, Patel NS, Stewart KN, Britt D, Pfeilschifter J, Mota-Filipe H, Cuzzocrea S et al.(2004). The cyclopentenone prostaglandin 15-deoxy-Delta (12, 14)-prostaglandin J2 ameliorates ischemic acute renal failure. Cardiovascular Research vol. 61, 630-643.

THIEMERMANN C, Collin M, Patel NSA(2004). Urocortin does not reduce the renal injury and dysfunction caused by experimental ischaemia/reperfusion. European Journal of Pharmacology vol. 496, 175-180.

Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, Allen DA, Harwood SM et al. (2003). Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion injury by the inhibition of the caspase cascade and apoptosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. vol. 14, 273A-273A.

THIEMERMANN C, Chatterjee PK, Patel NS, Fulia F, Cuzzocrea S, Ianaro A, Genovese T, Di Paola R et al.(2003). Pyrrolidine dithiocarbamate attenuates the developmnent of organ failure induced by zymosan in mice. Intensive Care Med. vol. 29, (11) 2016-2025.

Chatterjee PK, Kvale EO, Patel NSA, Thiemermann C(2003). GW274150 inhibits nitric oxide production by primary cultures of rat proximal tubular cells. Medical Science Monitor vol. 9, (10)

Mota-Filipe H, THIEMERMANN C, Patel NS, Chatterjee PK, Sivarajah A, Todorovic Z, Hattori Y, Stewart KN et al.(2003). Agonist of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury. Am. J. Nephrol. vol. 23, 267-276.

THIEMERMANN C, Yaqoob MM, Chatterjee PK, Patel NS, Brown PA, Stewart KN, Sivarajah A, Kvale EO et al.(2003). GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. Kidney Int. vol. 63, 853-865.

THIEMERMANN C, Patel NS, Cockerill GW, Chatterjee PK, Kvale EO, Britti D, Cuzzocrea S, Brown PA et al.(2003). High density lipoprotein (HDL) reduces renal ischemia/reperfusion injury. J. Am. Soc. Nephrol. vol. 14, 1833-1843.

THIEMERMANN C, Patel NS, Caputi AP, Dugo L, Cuzzocrea S, Mazzon E, Serraino I, Di Paola R et al.(2003). Reduction in the evolution of murine type 11 collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma. Arthritis Rheum. vol. 48, (12) 3544-3556.

THIEMERMANN C, Chatterjee PK, Patel NS, Lanaro A, Pisano B, Di Paola R, Genovese T, Di Rosa M et al.(2003). Rosiglitazone and 15-deoxy-{Delta}12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptro-{gamma} (PPAR-{gamma}), reduce ischaemia/reperfusion injury of the gut. Br. J. Pharmacol. vol. 140, (2) 366-376.

Chatterjee PK, Patel NSA, Kvale EO, Brown PAJ, Stewart KN, Britti D, Cuzzocrea S, Mota-Filipe H et al.(2003). The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat. Kidney International vol. 64, (5) 1605-1619.

THIEMERMANN C, Patel NS, Chatterjee PK, Mota-Filipe H, Cuzzocrea S, Kvale EO, Brown PA, Stewart KN(2002). Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int. vol. 61, 862-871.

THIEMERMANN C, Chatterjee PK, Patel NS, Chatterjee BE, Mota-Filipe H, Stewart KN, Brown PA, Cuzzocrea S et al.(2002). TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney. Free Radic. Biol. Med. vol. 33, 1575-1589.