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Publications:  Prof Steven Thornton

Allen M, Villeneuve E, Pitt M, Thornton S(2020). How can consultant-led childbirth care at time of delivery be maximised? A modelling study. BMJ Open vol. 10, (7)
10.1136/bmjopen-2019-034830
Saade G, Shennan A, Beach KJ, Hadar E, Parilla BV, Snidow J, Powell M, Montague TH et al.(2020). Randomized Trials of Retosiban Versus Placebo or Atosiban in Spontaneous Preterm Labor. Am J Perinatol
10.1055/s-0040-1710034
Shennan A, Chandiramani M, Bennett P, David AL, Girling J, Ridout A, Seed PT, Simpson N et al.(2020). MAVRIC: a multicenter randomized controlled trial of transabdominal vs transvaginal cervical cerclage. American Journal of Obstetrics and Gynecology vol. 222, (3) 261.e1-261.e9.
10.1016/j.ajog.2019.09.040
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63779
Norman JE, Norrie J, MacLennan G, Cooper D, Whyte S, Chowdhry S, Cunningham-Burley S, Mei X et al. (2020). Randomized controlled trial: Arabin pessary to prevent preterm birth in twin pregnancies with short cervix. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. vol. 222, S756-S756.
10.1016/j.ajog.2019.11.1275
Norman JE, Norrie J, Maclennan G, Cooper D, Whyte S, Burley SC, Smith JBE, Shennan A et al.(2018). Open randomised trial of the (Arabin) pessary to prevent preterm birth in twin pregnancy with health economics and acceptability: STOPPIT-2-a study protocol. BMJ Open vol. 8, (12)
10.1136/bmjopen-2018-026430
https://qmro.qmul.ac.uk/xmlui/handle/123456789/63093
Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A et al.(2018). Does progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM). Health Technology Assessment vol. 22, (35) 1-304.
10.3310/hta22350
Dowell J, Cleland J, Fitzpatrick S, McManus C, Nicholson S, Oppé T, Petty-Saphon K, King OS et al.(2018). The UK medical education database (UKMED) what is it? Why and how might you use it?. BMC Med Educ vol. 18, (1) 6-14.
10.1186/s12909-017-1115-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/36806
Thornton S(2017). UK medical education database: An issue of assumed Consent. Clinical Medicine, Journal of the Royal College of Physicians of London vol. 17, (2)
10.7861/clinmedicine.17-2-191
Thornton S, Valenzuela G, Baidoo C, Fossler MJ, Montague TH, Clayton L, Powell M, Snidow J et al.(2017). Treatment of spontaneous preterm labour with retosiban: a phase II pilot dose-ranging study. British Journal of Clinical Pharmacology vol. 83, (10) 2283-2291.
10.1111/bcp.13336
https://qmro.qmul.ac.uk/xmlui/handle/123456789/23545
Knight B, Smith H, Tregarthen A, Lapointe J, Shennan A, Taylor MJO, Thornton S(2016). Quantitative fetal fibronectin as a predictor of time to delivery in women undergoing induction of labour: a pilot study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY vol. 123, (13) E5-E5.
Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A et al.(2016). Vaginal Progesterone Prophylaxis for Preterm Birth (the OPPTIMUM Study): A Multicentre, Randomized, Double-Blind Trial. Obstetrical and Gynecological Survey vol. 71, (9) 517-518.
10.1097/01.ogx.0000494726.72702.fe
Knight HE, van der Meulen JH, Gurol-Urganci I, Smith GC, Kiran A, Thornton S, Richmond D, Cameron A et al.(2016). Birth “Out-of-Hours”: An Evaluation of Obstetric Practice and Outcome According to the Presence of Senior Obstetricians on the Labour Ward. PLoS Medicine vol. 13, (4)
10.1371/journal.pmed.1002000
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18843
Norman JE, Marlow N, Messow C-M, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A et al.(2016). Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet vol. 387, (10033) 2106-2116.
10.1016/S0140-6736(16)00350-0
https://qmro.qmul.ac.uk/xmlui/handle/123456789/12435
Kim SH, MacIntyre DA, Hanyaloglu AC, Blanks AM, Thornton S, Bennett PR, Terzidou V(2016). The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G<inf>αi</inf> signalling. Molecular and Cellular Endocrinology vol. 420, 11-23.
10.1016/j.mce.2015.11.012
Norman JE, Messow CM, Shennan A, Bennett P, Thornton S, Robson SC, Marlow N, Norrie J et al.(2016). LB2: Opptimum. American Journal of Obstetrics and Gynecology vol. 214, (1) S452-S453.
10.1016/j.ajog.2015.11.035
Norman JE, Messow CM, Shennan A, Bennett P, Thornton S, Robson SC, Marlow N, Norrie J et al. (2016). Opptimum. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. vol. 214, S452-S453.
10.1016/j.ajog.2015.11.035
Thornton S, Miller H, Valenzuela G, Snidow J, Stier B, Fossler MJ, Montague TH, Powell M et al.(2015). Treatment of spontaneous preterm labour with retosiban: A phase 2 proof-of-concept study. British Journal of Clinical Pharmacology vol. 80, (4) 740-749.
10.1111/bcp.12646
Kim SH, Tulsyan S, Da Silva FMA, Blanks A, Thornton S, Bennett PR, Terzidou V(2015). The proinflammatory effects of oxytocin in human myometrium require both Gaq and Gai proteins and are not inhibited by the oxytocin receptor antagonist- atosiban. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY vol. 122, 356-356.
Kim SH, MacIntyre DA, Firmino Da Silva M, Blanks AM, Lee YS, Thornton S, Bennett PR, Terzidou V(2015). Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues. Molecular and Cellular Endocrinology vol. 403, 64-77.
10.1016/j.mce.2014.11.008
Mccloskey C, Rada C, Bailey E, Mccavera S, van den Berg HA, Atia J, Rand DA, Shmygol A et al.(2014). The inwardly rectifying K<sup>+</sup> channel KIR7.1 controls uterine excitability throughout pregnancy. EMBO Molecular Medicine
10.15252/emmm.201403944
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24851
Kim SH, Blanks A, Thornton S, Bennett PR, Terzidou V(2014). 6.2 Atosiban activates NF-κB and pro-inflammatory pathways in human amnion via Gαi signalling. Archives of Disease in Childhood - Fetal and Neonatal Edition vol. 99, (Suppl 1) A7.3-A8.
10.1136/archdischild-2014-306576.21
Hughes A, Greisen G, Arce J-C, Thornton S(2014). Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at one year. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY vol. 121, (7) E6-E6.
Kay O, Hughes A, Saade G, Bennett P, Terzidou V, Thornton S(2014). Recent advances in the prevention and treatment of preterm labour: Oxytocin antagonists and the silicone (Arabin) pessary. Fetal and Maternal Medicine Review vol. 25, (2) 134-145.
10.1017/S0965539515000017
Duckitt K, Thornton S, O'Donovan OP, Dowswell T(2014). Nitric oxide donors for treating preterm labour. Cochrane Database of Systematic Reviews vol. 2014, (5)
10.1002/14651858.CD002860.pub2
Kim SH, Blanks A, Thornton S, Bennett PR, Terzidou V(2014). Oxytocin Receptor Antagonist, Atosiban, Drives Proinflammatory Effects in Human Amnion Via G(ai) Signaling. REPRODUCTIVE SCIENCES vol. 21, (3) 111A-111A.
Hughes A, Greisen G, Arce JC, Thornton S(2014). Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at 1 year. Acta Obstetricia et Gynecologica Scandinavica vol. 93, (1) 109-112.
10.1111/aogs.12258
Hyde C, Thornton S(2013). Does screening for pre-eclampsia make sense?. BJOG: An International Journal of Obstetrics and Gynaecology vol. 120, (10) 1168-1170.
10.1111/1471-0528.12309
Kim SH, Blanks A, Thornton S, Johnson M, Bennett PR, Terzidou V (2013). Activation of NF-kappa B in Human Amnion Is Mediated through G(ai) and Is Mimicked by the Oxytocin Receptor Antagonist - Atosiban. REPRODUCTIVE SCIENCES. vol. 20, 122A-122A.
Snidow J, Miller H, Valenzuela G, Thornton S, Stier B, Clayton L, Fossler M, Montague T et al. (2013). A multicenter, randomized, double-blind, placebo-controlled phase 2 trial of retosiban, a selective oxytocin receptor antagonist, for the management of preterm labor. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. vol. 208, S155-S155.
10.1016/j.ajog.2012.10.515
Allen M, Thornton S(2013). Providing one-to-one care in labour. Analysis of 'Birthrate Plus' labour ward staffing in real and simulated labour ward environments. BJOG: An International Journal of Obstetrics and Gynaecology vol. 120, (1) 100-107.
10.1111/j.1471-0528.2012.03483.x
Bru-Mercier G, Gullam JE, Thornton S, Blanks AM, Shmygol A(2012). Characterization of the tissue-level Ca<sup>2+</sup> signals in spontaneously contracting human myometrium. Journal of Cellular and Molecular Medicine vol. 16, (12) 2990-3000.
10.1111/j.1582-4934.2012.01626.x
https://qmro.qmul.ac.uk/xmlui/handle/123456789/32331
Norman JE, Shennan A, Bennett P, Thornton S, Robson S, Marlow N, Norrie J, Petrou S et al.(2012). Trial protocol OPPTIMUM- Does progesterone prophylaxis for the prevention of preterm labour improve outcome?. BMC Pregnancy and Childbirth vol. 12,
10.1186/1471-2393-12-79
https://qmro.qmul.ac.uk/xmlui/handle/123456789/24283
Khanjani S, Terzidou V, Lee YS, Thornton S, Johnson MR, Bennett PR(2011). Synergistic regulation of human oxytocin receptor promoter by CCAAT/: Enhancer-binding protein and RELA. Biology of Reproduction vol. 85, (5) 1083-1088.
10.1095/biolreprod.111.092304
Fernandes MS, Pierron V, Michalovich D, Astle S, Thornton S, Peltoketo H, Lam EWF, Gellersen B et al.(2005). Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues. Journal of Endocrinology vol. 187, (1) 89-101.
10.1677/joe.1.06242
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