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Publications:  Dr Meng-Lay Lin

Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM et al.(2017). The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1. Oncotarget vol. 8, (13) 21609-21625.
Harrod A, Fulton J, Nguyen VTM, Periyasamy M, Ramos-Garcia L, Lai C-F, Metodieva G, de Giorgio A et al.(2016). Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene Article August, 1-11.
Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW et al.(2016). LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. Nucleic Acids Research vol. 44, Article 2, 582-594.
Lin M-L, Patel H, Remenyi J, Banerji CRS, Lai C-F, Periyasamy M, Lombardo Y, Busonero C et al.(2015). Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer. Oncotarget vol. 6, Article 25,
Pavlopoulos GA, Kumar P, Sifrim A, Sakai R, Lin ML, Voet T, Moreau Y, Aerts J(2013). Meander: Visually exploring the structural variome using space-filling curves. Nucleic Acids Research vol. 41, Article 11,
Voet T, Kumar P, Van Loo P, Cooke SL, Marshall J, Lin ML, Esteki MZ, Van Der Aa N et al.(2013). Single-cell paired-end genome sequencing reveals structural variation per cell cycle. Nucleic Acids Research vol. 41, Article 12, 6119-6138.
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D et al.(2011). Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma. nature vol. 186, Article 3, 1150-1150.
Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW et al.(2011). Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell vol. 144, Article 1, 27-40.
Pleasance ED, Stephens PJ, O Meara S, McBride DJ, Meynert A, Jones D, Lin M-L, Beare D et al.(2010). A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature vol. 463, Article 7278, 184-190.
Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Davies H, Edkins S et al.(2010). Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature vol. 463, Article 7279, 360-3.
Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, Morsberger LA, Latimer C et al.(2010). The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature vol. 467, Article 7319, 1-5.
Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ, Greenman CD, Varela I, Lin M-L et al.(2009). A comprehensive catalogue of somatic mutations from a human cancer genome. Nature vol. 463, Article 7278, 191-196.
Kim JW, Akiyama M, Park JH, Lin ML, Shimo A, Ueki T, Daigo Y, Tsunoda T et al.(2009). Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer. Cancer Science vol. 100, Article 8, 1468-1478.
Stephens PJ, McBride DJ, Lin M-L, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C et al.(2009). Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature vol. 462, Article 7276, 1005-10.
Lin ML, Fukukawa C, Park JH, Naito K, Kijima K, Shimo A, Ajiro M, Nishidate T et al.(2009). Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis. Cancer Science vol. 100, Article 8, 1443-1450.
Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T et al.(2009). Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells. International Journal of Oncology vol. 35, Article 4, 673-681.
van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C et al.(2009). Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature genetics vol. 41, Article 5, 521-3.
Ueki T, Nishidate T, Park JH, Lin ML, Shimo A, Hirata K, Nakamura Y, Katagiri T(2008). Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells. Oncogene vol. 27, Article 43, 5672-5683.
Shimo A, Tanikawa C, Nishidate T, Lin ML, Matsuda K, Park JH, Ueki T, Ohta T et al.(2008). Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis. Cancer Science vol. 99, Article 1, 62-70.
Lin M-L, Park J-H, Nishidate T, Nakamura Y, Katagiri T(2007). Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Breast cancer research : BCR vol. 9, Article 1, R17-R17.
Park JH, Lin ML, Nishidate T, Nakamura Y, Katagiri T(2006). PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer. Cancer Research vol. 66, Article 18, 9186-9195.
Nishidate T, Katagiri T, Lin ML, Mano Y, Miki Y, Kasumi F, Yoshimoto M, Tsunoda T et al.(2004). Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis. International journal of oncology vol. 25, Article 4, 797-819.
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