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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Zuzana Licenikova Horejsi

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Konopka A, Whelan DR, Jamali MS, Perri E, Shahheydari H, Toth RP, Parakh S, Robinson T et al. ( 2020 ) . Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations . Molecular Neurodegeneration vol. 15 , ( 1 )
von Morgen P, Lidak T, Horejsi Z, Macurek L ( 2018 ) . Nuclear localisation of 53BP1 is regulated by phosphorylation of the nuclear localisation signal . Biology of the Cell vol. 110 , ( 6 ) 137 - 146 .
Malinová A, Cvačková Z, Matějů D, Hořejší Z, Abéza C, Vandermoere F, Bertrand E, Staněk D et al. ( 2017 ) . Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones . Journal of Cell Biology vol. 216 , ( 6 ) 1579 - 1596 .
von Morgen P, Burdova K, Flower TG, O'Reilly NJ, Boulton SJ, Smerdon SJ, Macurek L, Hořejší Z ( 2017 ) . MRE11 stability is regulated by CK2-dependent interaction with R2TP complex . Oncogene vol. 36 , ( 34 ) 4943 - 4950 .
Hiraga S, Ly T, Garzón J, Hořejší Z, Ohkubo Y, Endo A, Obuse C, Boulton SJ et al. ( 2017 ) . Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation . EMBO Reports vol. 18 , ( 3 ) 403 - 419 .
von Morgen P, Hořejší Z, Macurek L ( 2015 ) . Substrate recognition and function of the R2TP complex in response to cellular stress . Frontiers in Genetics vol. 6 ,
Horejŝí Z, Collis SJ, Boulton SJ ( 2014 ) . FANCM-FAAP24 and HCLK2: Roles in ATR signalling and the Fanconi Anemia pathway . Cell Cycle vol. 8 , ( 8 ) 1133 - 1137 .
Hořejší Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O’Reilly NJ, Ogrodowicz RW et al. ( 2014 ) . Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex . Cell Reports vol. 7 , ( 1 ) 19 - 26 .
Adelman CA, Lolo RL, Birkbak NJ, Murina O, Matsuzaki K, Horejsi Z, Parmar K, Borel V et al. ( 2013 ) . HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis . Nature vol. 502 , ( 7471 ) 381 - 384 .
Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan AR et al. ( 2013 ) . Tripartite Motif-containing 33 (TRIM33) Protein Functions in the Poly(ADP-ribose) Polymerase (PARP)-dependent DNA Damage Response through Interaction with Amplified in Liver Cancer 1 (ALC1) Protein* . Journal of Biological Chemistry vol. 288 , ( 45 ) 32357 - 32369 .
Hořejší Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T et al. ( 2010 ) . CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability . Molecular Cell vol. 39 , ( 6 ) 839 - 850 .
Adamo A, Collis SJ, Adelman CA, Silva N, Horejsi Z, Ward JD, Martinez-Perez E, Boulton SJ et al. ( 2010 ) . Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia . Molecular Cell vol. 39 , ( 1 ) 25 - 35 .
Novakova Z, Hubackova S, Kosar M, Janderova-Rossmeislova L, Dobrovolna J, Vasicova P, Vancurova M, Horejsi Z et al. ( 2009 ) . Cytokine expression and signaling in drug-induced cellular senescence . Oncogene vol. 29 , ( 2 ) 273 - 284 .
Ahel D, Hořejší Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M et al. ( 2009 ) . Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1 . Science vol. 325 , ( 5945 ) 1240 - 1243 .
Collis SJ, Ciccia A, Deans AJ, Hořejší Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ et al. ( 2008 ) . FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex . Molecular Cell vol. 32 , ( 3 ) 313 - 324 .
Bartkova J, Hořejs̆í Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebæk NE, Stucki M, Jackson S et al. ( 2007 ) . DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours . Oncogene vol. 26 , ( 53 ) 7414 - 7422 .
Bartkova J, Hořejší Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M et al. ( 2005 ) . DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis . Nature vol. 434 , ( 7035 ) 864 - 870 .
Hořejší Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J ( 2004 ) . Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation . Oncogene vol. 23 , ( 17 ) 3122 - 3127 .
Pajer P, Pečenka V, Karafiát V, Králová J, Hořejší Z, Dvořák M ( 2003 ) . The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma . Oncogene vol. 22 , ( 5 ) 665 - 673 .
Karafiát V, Dvořáková M, Pajer P, Králová J, Hořejšı́ Z, Čermák V, Bartůněk P, Zenke M et al. ( 2001 ) . The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors . Blood vol. 98 , ( 13 ) 3668 - 3676 .
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