Publications:  Dr Zuzana Licenikova Horejsi

von Morgen P, Lidak T, Horejsi Z, Macurek L(2018). Nuclear localisation of 53BP1 is regulated by phosphorylation of the nuclear localisation signal. Biol Cell vol. 110, (6) 137-146.

von Morgen P, Burdova K, Flower TG, O'Reilly NJ, Boulton SJ, Smerdon SJ, Macurek L, Ho¿ejší Z(2017). MRE11 stability is regulated by CK2-dependent interaction with R2TP complex. Oncogene vol. 36, (34) 4943-4950.

Malinová A, Cva¿ková Z, Mat¿j¿ D, Ho¿ejší Z, Abéza C, Vandermoere F, Bertrand E, Stan¿k D et al.(2017). Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. J Cell Biol vol. 216, (6) 1579-1596.

Hiraga S-I, Ly T, Garzón J, Ho¿ejší Z, Ohkubo Y-N, Endo A, Obuse C, Boulton SJ et al.(2017). Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. EMBO Rep vol. 18, (3) 403-419.

von Morgen P, Ho¿ejší Z, Macurek L(2015). Substrate recognition and function of the R2TP complex in response to cellular stress. Front Genet vol. 6,

Ho¿ejší Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW et al.(2014). Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex. Cell Rep vol. 7, (1) 19-26.

Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan AR et al.(2013). Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein. J Biol Chem vol. 288, (45) 32357-32369.

Adelman CA, Lolo RL, Birkbak NJ, Murina O, Matsuzaki K, Horejsi Z, Parmar K, Borel V et al.(2013). HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature vol. 502, (7471) 381-384.

Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T et al.(2010). CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell vol. 39, (6) 839-850.

Adamo A, Collis SJ, Adelman CA, Silva N, Horejsi Z, Ward JD, Martinez-Perez E, Boulton SJ et al.(2010). Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell vol. 39, (1) 25-35.

Novakova Z, Hubackova S, Kosar M, Janderova-Rossmeislova L, Dobrovolna J, Vasicova P, Vancurova M, Horejsi Z et al.(2010). Cytokine expression and signaling in drug-induced cellular senescence. Oncogene vol. 29, (2) 273-284.

Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M et al.(2009). Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science vol. 325, (5945) 1240-1243.

Horej¿í Z, Collis SJ, Boulton SJ(2009). FANCM-FAAP24 and HCLK2: roles in ATR signalling and the Fanconi anemia pathway. Cell Cycle vol. 8, (8) 1133-1137.

Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ et al.(2008). FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell vol. 32, (3) 313-324.

Bartkova J, Horejsí Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebaek NE, Stucki M, Jackson S et al.(2007). DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene vol. 26, (53) 7414-7422.

Bartkova J, Horejsí Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M et al.(2005). DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature vol. 434, (7035) 864-870.

Horejsí Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J(2004). Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene vol. 23, (17) 3122-3127.

Pajer P, Pecenka V, Karafiát V, Králová J, Horejsí Z, Dvorák M(2003). The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma. Oncogene vol. 22, (5) 665-673.

Karafiát V, Dvoráková M, Pajer P, Králová J, Horejsí Z, Cermák V, Bart¿nek P, Zenke M et al.(2001). The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors. Blood vol. 98, (13) 3668-3676.