Publications:  Miss Jacqueline Cooper

PETERSEN SE, AUNG N, SANGHVI M, ZEMRAK F, LEE A, COOPER J, PAIVA J, Thomson R et al.(2018). Association between ambient air pollution and cardiac morpho-functional phenotypes: Insights from the UK Biobank population imaging study. Circulation

PETERSEN SE(2018). Prospective Association between Handgrip Strength and Cardiac Structure and Function in UK adults. PLoS ONE

PETERSEN SE, SANGHVI M, AUNG N, COOPER J, PAIVA J, LEE A, ZEMRAK F, FUNG K et al.(2018). The impact of menopausal hormone therapy (MHT) on cardiac structure and function: insights from the UK Biobank imaging enhancement study. PLoS ONE

PETERSEN SE(2017). The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study. PLoS ONE

Sanders J, Cooper JA, Farrar D, Braithwaite S, Sandhu U, Mythen MG, Montgomery HE(2017). Pre-operative anaemia is associated with total morbidity burden on days 3 and 5 after cardiac surgery: a cohort study. Perioper Med (Lond) vol. 6, 1-1.

Tirlapur N, Puthucheary ZA, Cooper JA, Sanders J, Coen PG, Moonesinghe SR, Wilson AP, Mythen MG et al.(2016). Diarrhoea in the critically ill is common, associated with poor outcome, and rarely due to Clostridium difficile. Scientific Reports vol. 6,

Boardman-Pretty F, Smith AJP, Cooper J, Palmen J, Folkersen L, Hamsten A, Catapano AL, Melander O et al.(2015). Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant. Circulation: Cardiovascular Genetics vol. 8, (5) 696-706.

Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JEL, Shah T, Sofat R, Stender S et al.(2015). HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials. The Lancet vol. 385, (9965) 351-361.

Holmes MV, Frikke-Schmidt R, Melis D, Luben R, Asselbergs FW, Boer JMA, Cooper J, Palmen J et al.(2014). A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease. Atherosclerosis vol. 237, (1) 5-12.

Holmes MV, Exeter HJ, Folkersen L, Nelson CP, Guardiola M, Cooper JA, Sofat R, Boekholdt SM et al.(2014). Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. Circ Cardiovasc Genet vol. 7, (2) 144-150.

Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JEL, Shah T, Sofat R, Guo Y, Chung C et al.(2012). The interleukin-6 receptor as a target for prevention of coronary heart disease: A mendelian randomisation analysis. The Lancet vol. 379, (9822) 1214-1224.

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I et al.(2011). Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics vol. 89, (6) 688-700.

Smart MC, Dedoussis G, Yiannakouris N, Grisoni ML, Dror GK, Yannakoulia M, Papoutsakis C, Louizou E et al.(2011). Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures. Nutr Metab Cardiovasc Dis vol. 21, (7) 476-484.

Smart-Halajko MC, Kelley-Hedgepeth A, Montefusco MC, Cooper JA, Kopin A, McCaffrey JM, Balasubramanyam A, Pownall HJ et al.(2011). ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial. BMC Med Genet vol. 12,

Casas JP, Ninio E, Panayiotou A, Palmen J, Cooper JA, Ricketts SL, Sofat R, Nicolaides AN et al.(2010). PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A2 Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry (vol 121, pg 2284, 2010). CIRCULATION vol. 122, (3) E400-E400.

Casas JP, Ninio E, Panayiotou A, Palmen J, Cooper JA, Ricketts SL, Sofat R, Nicolaides AN et al.(2010). PLA2G7 Genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of european ancestry. Circulation vol. 121, (21) 2284-2293.

Salpea KD, Talmud PJ, Cooper JA, Maubaret CG, Stephens JW, Abelak K, Humphries SE(2010). Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis vol. 209, (1) 42-50.

Caplin B, Nitsch D, Gill H, Hoefield R, Blackwell S, MacKenzie D, Cooper JA, Middleton RJ et al.(2010). Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms. Kidney Int vol. 77, (5) 459-467.

Talmud PJ, Hingorani AD, Cooper JA, Marmot MG, Brunner EJ, Kumari M, Kivimäki M, Humphries SE(2010). Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ vol. 340,

Smith AJP, D'Aiuto F, Palmen J, Cooper JA, Samuel J, Thompson S, Sanders J, Donos N et al.(2008). Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism. Clinical Chemistry vol. 54, (5) 841-850.

Muthumala A, Gable DR, Palmen J, Cooper JA, Stephens JW, Miller GJ, Humphries SE(2007). Is the influence of variation in the ACE gene on the prospective risk of Type 2 diabetes in middle-aged men modified by obesity?. Clin Sci (Lond) vol. 113, (12) 467-472.

Humphries SE, Gable D, Cooper JA, Ireland H, Stephens JW, Hurel SJ, Li KW, Palmen J et al.(2006). Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J Mol Med (Berl) vol. 84, (12) 1005-1014.

Griffin MD, Sanders TAB, Davies IG, Morgan LM, Millward DJ, Lewis F, Slaughter S, Cooper JA et al.(2006). Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: The OPTILIP study. American Journal of Clinical Nutrition vol. 84, (6) 1290-1298.

Humphries SE, Whittall RA, Hubbart CS, Maplebeck S, Cooper JA, Soutar AK, Naoumova R, Thompson GR et al.(2006). Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk. J Med Genet vol. 43, (12) 943-949.

Vieira JRS, Whittall RA, Cooper JA, Miller GJ, Humphries SE(2006). The A370T variant (StuI polymorphism) in the LDL receptor gene is not associated with plasma lipid levels or cardiovascular risk in UK men. Ann Hum Genet vol. 70, (Pt 6) 697-704.

Sanders TAB, Lewis F, Slaughter S, Griffin BA, Griffin M, Davies I, Millward DJ, Cooper JA et al.(2006). Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of α-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: The OPTILIP Study. American Journal of Clinical Nutrition vol. 84, (3) 513-522.

Shah T, Cooper JA, Casas JP, Pearce K, Tinworth L, Hingorani AD, Miller GJ, Humphries SE (2006). CRP in the prediction and pathogenesis of cardiovascular events in middle-aged men; Results from the NPHSII study. ATHEROSCLEROSIS. vol. 186, S3-S3.

Smid M, Govers-Riemslag JWP, Cooper JA, Fens DCEM, Hackz CE, Spronk MHM, Bauery KA, Rosenbergy RD et al. (2006). The Plasma Kallikrein-Kinin System and its predictive role in coronary heart disease and ischaemic stroke; follow up from the Second Northwick Park Heart Study. BRITISH JOURNAL OF HAEMATOLOGY. vol. 133, 10-10.

Miller GJ, Cooper JA, Beckles GLA(2005). Cardiorespiratory fitness, all-cause mortality, and risk of cardiovascular disease in Trinidadian men - The St. James survey. International Journal of Epidemiology vol. 34, (6) 1387-1394.

Humphries SE, Whittall R, Hubbard C, Cooper JA, Soutar A, Naoumova R, Thompson GR, Seed M et al. (2005). The utility of DNA-based testing in patients with familial hypercholesterolaemia in the UK. ATHEROSCLEROSIS. vol. 182, S5-S5.

Cooper JA, Miller GJ, Humphries SE(2005). A comparison of the PROCAM and Framingham point-scoring systems for estimation of individual risk of coronary heart disease in the Second Northwick Park Heart Study. Atherosclerosis vol. 181, (1) 93-100.

Younis J, Cooper JA, Miller GJ, Humphries SE, Talmud PJ(2005). Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study. Atherosclerosis vol. 180, (2) 225-232.

Stephens JW, Dhamrait SS, Cooper JA, Acharya J, Miller GJ, Hurel SJ, Humphries SE(2005). The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects. Molecular Genetics and Metabolism vol. 84, (1) 83-89.

Miller GJ, Bauer KA, Howarth DJ, Cooper JA, Humphries SE, Rosenberg RD(2004). Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway. J Thromb Haemost vol. 2, (12) 2107-2114.

Stephens JW, Hurel SJ, Cooper JA, Acharya J, Miller GJ, Humphries SE(2004). A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus. Mol Genet Metab vol. 82, (2) 180-186.

Hattori H, Kujiraoka T, Egashira T, Saito E, Fujioka T, Takahashi S, Ito M, Cooper JA et al.(2004). Association of coronary heart disease with pre-beta-HDL concentrations in Japanese men. Clin Chem vol. 50, (3) 589-595.

Dhamrait SS, Stephens JW, Cooper JA, Acharya J, Mani AR, Moore K, Miller GJ, Humphries SE et al.(2004). Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2. Eur Heart J vol. 25, (6) 468-475.

MACCALLUM PK, Meade TW, Lowe GDO, Rumley A, Cooper JA(2004). Effect of bezafibrate on plasma homocysteine concentration in men with lower extremity arterial disease. J Thromb Haemost vol. 2, 364-365.

Miller GJ, Bauer KA, Howarth DJ, Cooper JA, Humphries SE, Rosenberg RD(2004). Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway. Journal of Thrombosis and Haemostasis vol. 2, (12) 2107-2114.

Sanders TAB, Oakley FR, Crook D, Cooper JA, Miller GJ(2003). High intakes of trans monounsaturated fatty acids taken for 2 weeks do not influence procoagulant and fibrinolytic risk markers for CHD in young healthy men. Br J Nutr vol. 89, (6) 767-776.

Bowles LK, MACCALLUM PK, Miller GJ, Howarth DJ, Cooper JA(2003). Associations of haemostatic variables with body mass index: a community-based study. Blood Coagul Fibrinolysis vol. 14, 569-573.

Kohler HP, Ariëns RAS, Catto AJ, Carter AM, Miller GJ, Cooper JA, Mansfield MW, Standeven KF et al.(2002). Factor XIII A-subunit concentration predicts outcome in stroke subjects and vascular outcome in healthy, middle-aged men. British Journal of Haematology vol. 118, (3) 825-832.

Miller GJ, Bauer KA, Howarth DJ, Mitchell JP, Cooper JA(2002). Does inflammatory proteolytic activity contribute to the increased factor IX activation peptide in men at high risk of coronary heart disease? A preliminary study. Thromb Haemost vol. 87, (3) 415-420.

Miller GJ, Cooke CJ, Nanjee MN, Howarth DJ, Cooper JA, Stepanova IP, Morrissey JH, Miller NE(2002). Factor VII activation, apolipoprotein A-I and reverse cholesterol transport: possible relevance for postprandial lipaemia. Thromb Haemost vol. 87, (3) 477-482.

Gaunt TR, Cooper JA, Miller GJ, Day INM, O'Dell SD(2001). Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Human Molecular Genetics vol. 10, (14) 1491-1501.

Cooper JA, Miller GJ, Bauer KA, Morrissey JH, Meade TW, Howarth DJ, Barzegar S, Mitchell JP et al.(2000). Comparison of novel hemostatic factors and conventional risk factors for prediction of coronary heart disease. Circulation vol. 102, (23) 2816-2822.

Hattori H, Kujiroaka T, Egashira T, Miyazaki A, Cooper JA, Nanjee N, Miller NE(2000). Coronary heart disease is strongly associated with plasma Prep beta LPA-I concentration: Impact of high density lipoprotein remodelling by cholesteryl ester and phospholipid transfer proteins. CIRCULATION vol. 102, (18) 284-284.

Bauer KA, Humphries S, Smillie B, Li L, Cooper JA, Barzegar S, Rosenberg RD, Miller GJ(2000). Prothrombin activation is increased among asymptomatic carriers of the prothrombin G20210A and factor V Arg506Gln mutations. Thromb Haemost vol. 84, (3) 396-400.

MacCallum PK, Cooper JA, Martin J, Howarth DJ, Meade TW, Miller GJ(2000). Haemostatic and lipid determinants of prothrombin fragment F1.2 and D-dimer in plasma. Thromb Haemost vol. 83, (3) 421-426.

Sayer JW, Marchant B, Gelding SV, Cooper JA, Timmis AD(2000). Autonomic dysfunction is related to impaired pancreatic beta cell function in patients with coronary artery disease. Heart vol. 83, (2) 210-216.

Welton AJ, Vickers MR, Cooper JA, Meade TW, Marteau TM(1999). Is recruitment more difficult with a placebo arm in RCTs? Reply. BRITISH MEDICAL JOURNAL vol. 319, (7213) 854-854.

MacCallum PK, Cooper JA, Howarth DJ, Martin JC, Meade TW, Miller GJ(1999). Determinants of activated factor XII in a healthy population. THROMBOSIS AND HAEMOSTASIS275-275.

Grant PJ, Miller GJ, Cooper JA, Bauer KA, Rosenberg RD(1999). Elevated tissue plasminogen activator and D-dimer concentrations precede myocardial infarction in a healthy cohort of middle aged males (Northwick Park Heart Study II). THROMBOSIS AND HAEMOSTASIS447-447.

Welton AJ, Vickers MR, Cooper JA, Meade TW, Marteau TM(1999). Is recruitment more difficult with a placebo arm in randomised controlled trials? A quasirandomised, interview based study. BMJ vol. 318, (7191) 1114-1117.

MacCallum PK, Cooper JA, Howarth DJ, Attfield J, Meade TW, Miller GJ(1999). Determinants of the euglobulin clot lysis time and a comparison with the dilute whole blood clot lysis time. BRITISH JOURNAL OF HAEMATOLOGY vol. 105, 95-95.

MacCallum PK, Cooper JA, Martin J, Howarth DJ, Meade TW, Miller GJ(1998). Hemostatic and lipid determinants of prothrombin fragment F1.2 and D-dimer. BLOOD vol. 92, (10) 96B-96B.

Cooke CJ, Nanjee MN, Dewey P, Cooper JA, Miller GJ, Miller NE(1998). Plant monoterpenes do not raise plasma high-density-lipoprotein concentrations in humans. Am J Clin Nutr vol. 68, (5) 1042-1045.

Miller GJ, Mitropoulos KA, Nanjee MN, Howarth DJ, Martin JC, Esnouf MP, Reeves BE, Miller NE et al.(1998). Very low activated factor VII and reduced factor VII antigen in familial abetalipoproteinaemia. Thromb Haemost vol. 80, (2) 233-238.

MacCallum PK, Cooper JA, Martin J, Howarth DJ, Meade TW, Miller GJ(1998). Associations of protein C and protein S with serum lipid concentrations. Br J Haematol vol. 102, (2) 609-615.

MacCallum PK, Cooper JA, Martin J, Howarth DJ, Meade TW, Miller GJ(1998). Association of total and free protein S antigen with serum lipids. BRITISH JOURNAL OF HAEMATOLOGY vol. 101, 81-81.

O'Dell SD, Bolla MK, Miller GJ, Cooper JA, Humphries SE, Day IN(1998). W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample. Int J Obes Relat Metab Disord vol. 22, (4) 377-379.

Miller GJ, Bauer KA, Cooper JA, Rosenberg RD(1998). Activation of the coagulant pathway in cigarette smokers. Thromb Haemost vol. 79, (3) 549-553.

MacCallum PK, Cooper JA, Howarth DJ, Meade TW, Miller GJ(1998). Sex differences in the determinants of fibrinolytic activity. Thrombosis and Haemostasis vol. 79, (3) 587-590.

Hall S, Chu G, Miller G, Cruickshank K, Cooper JA, Humphries SE, Talmud PJ(1997). A common mutation in the lipoprotein lipase gene promoter, -93T/G, is associated with lower plasma triglyceride levels and increased promoter activity in vitro. Arterioscler Thromb Vasc Biol vol. 17, (10) 1969-1976.

Miller GJ, Esnouf MP, Burgess AI, Cooper JA, Mitchell JP(1997). Risk of coronary heart disease and activation of factor XII in middle-aged men. Arterioscler Thromb Vasc Biol vol. 17, (10) 2103-2106.

O'Dell SD, Miller GJ, Cooper JA, Hindmarsh PC, Pringle PJ, Ford H, Humphries SE, Day IN(1997). Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males. Int J Obes Relat Metab Disord vol. 21, (9) 822-825.

Meade TW, Cooper JA, Miller GJ(1997). Platelet counts and aggregation measures in the incidence of ischaemic heart disease (IHD). Thromb Haemost vol. 78, (2) 926-929.

Miller GJ, Bauer KA, Cooper JA, Rosenberg RD(1997). Activation of the coagulation pathway in cigarette smokers. THROMBOSIS AND HAEMOSTASISP2490-P2490.

MacCallum PK, Cooper JA, Howarth DJ, Meade TW, Miller GJ(1997). Effect of serum lipid levels on protein C activity and antigen. THROMBOSIS AND HAEMOSTASISP1704-P1704.

Meade TW, Cooper JA, Chakrabarti R, Miller GJ, Stirling Y, Howarth DJ(1996). Fibrinolytic activity and clotting factors in ischaemic heart disease in women. BMJ vol. 312, (7046)

Miller GJ, Martin JC, Mitropoulos KA, Esnouf MP, Cooper JA, Morrissey JH, Howarth DJ, Tuddenham EG(1996). Activation of factor VII during alimentary lipemia occurs in healthy adults and patients with congenital factor XII or factor XI deficiency, but not in patients with factor IX deficiency. Blood vol. 87, (10) 4187-4196.

Miller GJ, Bauer KA, Barzegar S, Cooper JA, Rosenberg RD(1996). Increased activation of the haemostatic system in men at high risk of fatal coronary heart disease. Thromb Haemost vol. 75, (5) 767-771.

MacCallum PK, Cooper JA, Meade TW, Howarth DJ, Miller GJ(1996). A comparison of the associations of prothrombin fragment F1.2 and D-dimer in a healthy population. BRITISH JOURNAL OF HAEMATOLOGY vol. 93, 133-133.

Mitropoulos KA, Martin JC, Stirling Y, Morrisey JH, Cooper JA(1995). Activation of factors XII and VII induced in citrated plasma in the presence of contact surface. Thromb Res vol. 78, (1) 67-75.

MacCallum PK, Meade TW, Cooper JA, Stirling Y, Howarth DJ, Ruddock V, Miller GJ(1995). Clotting factor VIII and risk of deep-vein thrombosis. Lancet vol. 345, (8952)

Miller GJ, Bauer KA, Barzegar S, Foley AJ, Mitchell JP, Cooper JA, Rosenberg RD(1995). The effects of quality and timing of venepuncture on markers of blood coagulation in healthy middle-aged men. Thromb Haemost vol. 73, (1) 82-86.

Meade TW, Cooper JA, Stirling Y, Howarth DJ, Ruddock V, Miller GJ(1994). Factor VIII, ABO blood group and the incidence of ischaemic heart disease. Br J Haematol vol. 88, (3) 601-607.

Mitropoulos KA, Miller GJ, Howarth DJ, Reeves BE, Cooper JA(1994). The effects of intravenous Triton WR-1339 on factor VII coagulant activity and plasma lipoproteins in normocholesterolaemic and hypercholesterolaemic rabbits. Blood Coagul Fibrinolysis vol. 5, (4) 583-591.

Miller GJ, Lewis LL, Colman SM, Cooper JA, Lloyd G, Scollen N, Jones N, Tedder RS et al.(1994). Clustering of human T lymphotropic virus type I seropositive in Montserrat, West Indies: evidence for an environmental factor in transmission of the virus. J Infect Dis vol. 170, (1) 44-50.

MEADE TW, COOPER JA, PEART WS(1994). PLASMA-RENIN ACTIVITY AND ISCHEMIC-HEART-DISEASE - REPLY. NEW ENGLAND JOURNAL OF MEDICINE vol. 330, (7) 507-507.

Miller GJ, Stirling Y, Esnouf MP, Heinrich J, van de Loo J, Kienast J, Wu KK, Morrissey JH et al.(1994). Factor VII-deficient substrate plasmas depleted of protein C raise the sensitivity of the factor VII bio-assay to activated factor VII: an international study. Thromb Haemost vol. 71, (1) 38-48.

Meade TW, Cooper JA, Peart WS(1993). Plasma renin activity and ischemic heart disease. N Engl J Med vol. 329, (9) 616-619.

Connelly JB, Roderick PJ, Cooper JA, Meade TW, Miller GJ(1993). Positive association between self-reported fatty food consumption and factor VII coagulant activity, a risk factor for coronary heart disease, in 4246 middle-aged men. Thromb Haemost vol. 70, (2) 250-252.

Mitropoulos KA, Reeves BE, O'Brien DP, Cooper JA, Martin JC(1993). The relationship between factor VII coagulant activity and factor XII activation induced in plasma by endogenous or exogenously added contact surface. Blood Coagul Fibrinolysis vol. 4, (2) 223-234.

Connelly JB, Cooper JA, Meade TW(1992). Strenuous exercise, plasma fibrinogen, and factor VII activity. Br Heart J vol. 67, (5) 351-354.