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Publications:  Dr Louisa James

Baker D, Pryce G, James LK, Marta M, Schmierer K(2020). The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis. Multiple Sclerosis and Related Disorders Article 102279, 102279-102279.
10.1016/j.msard.2020.102279
James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR et al.(2020). Distinct microbial and immune niches of the human colon. Nature Immunology vol. 21, (3) 343-353.
10.1038/s41590-020-0602-z
Baker D, Pryce G, James LK, Schmierer K, Giovannoni G(2020). Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis. European Journal of Neurology vol. 27, (2) 221-228.
10.1111/ene.14105
https://qmro.qmul.ac.uk/xmlui/handle/123456789/62987
Kariyawasam HH, James LK, Gane SB(2020). Dupilumab: Clinical efficacy of blocking IL-4/IL-13 signalling in chronic rhinosinusitis with nasal polyps. Drug Design, Development and Therapy vol. 14, 1757-1769.
10.2147/DDDT.S243053
Santos AF, Barbosa-Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O¿Rourke C, Bahnson HT et al.(2020). IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE. Allergy: European Journal of Allergy and Clinical Immunology
10.1111/all.14301
Santos AF, James LK, Kwok M, McKendry RT, Anagnostou K, Clark AT, Lack G(2020). Peanut oral immunotherapy induces blocking antibodies but does not change the functional characteristics of peanut-specific IgE. Journal of Allergy and Clinical Immunology vol. 145, (1) 440-443.e5.
10.1016/j.jaci.2019.09.005
Bucaite G, Kang-Pettinger T, Moreira J, Gould HJ, James LK, Sutton BJ, McDonnell JM(2019). Interplay between affinity and valency in effector cell degranulation: A model system with polcalcin allergens and human patient–derived IgE antibodies. Journal of Immunology vol. 203, (7) 1693-1700.
10.4049/jimmunol.1900509
Mckendry RT, Kwok M, Hemmings O, James L, Santos AF (2019). Basophil and mast cell responses to food allergens in sensitised but tolerant patients are not mediated via the FcgRIIa and FcgRIIb receptors. ALLERGY. vol. 74, 97-97.
Gould HJ, James LK(2019). Orchestration of immunoglobulin isotypes, subclasses, and specificities in patients receiving intravenous IgG or subcutaneous immunotherapy and those with chronic rhinosinusitis with nasal polyps: Toward precision medicine. Journal of Allergy and Clinical Immunology
10.1016/j.jaci.2019.05.027
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58424
Upton NEG, Hayday TS, James LK(2019). Isolation and characterization of lymphocytes from human mucosal biopsies. Methods in Molecular Biology, vol. 2020,
Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ et al.(2018). Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition. Proceedings of the National Academy of Sciences of the United States of America vol. 115, (37) E8707-E8716.
10.1073/pnas.1806840115
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44963
Dhaliwal B, Pang MOY, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ(2017). IgE binds asymmetrically to its B cell receptor CD23. Scientific Reports vol. 7,
10.1038/srep45533
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56107
Chen J-B, James LK, Davies AM, Wu Y-CB, Rimmer J, Lund VJ, Chen J-H, McDonnell JM et al.(2016). Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology vol. 139, (4) 1195-1204.e11.
10.1016/j.jaci.2016.06.066
https://qmro.qmul.ac.uk/xmlui/handle/123456789/22660
James LK, Till SJ(2016). Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions. Current Allergy and Asthma Reports vol. 16, (3) 1-7.
10.1007/s11882-016-0600-2
Gadermaier E, James LK, Shamji MH, Blatt K, Fauland K, Zieglmayer P, Garmatiuk T, Focke-Tejkl M et al.(2016). Epitope specificity determines cross-protection of a SIT-induced IgG<inf>4</inf> antibody. Allergy: European Journal of Allergy and Clinical Immunology vol. 71, (1) 36-46.
10.1111/all.12710
James LK(2016). The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy. Current Allergy and Asthma Reports vol. 16, (2) 1-9.
10.1007/s11882-015-0588-z
Steveling EH, Lao-Araya M, Koulias C, Scadding G, Eifan A, James LK, Dumitru A, Penagos M et al.(2015). Protocol for a randomised, double-blind, placebo-controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: Time course of nasal, cutaneous and immunological outcomes. Clinical and Translational Allergy vol. 5, (1)
10.1186/s13601-015-0087-2
Santos AF, James LK, Bahnson HT, Shamji MH, Couto-Francisco NC, Islam S, Houghton S, Clark AT et al.(2015). IgG<inf>4</inf> inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens. Journal of Allergy and Clinical Immunology vol. 135, (5) 1249-1256.
10.1016/j.jaci.2015.01.012
Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM, Durham SR, Sutton BJ et al.(2015). Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class. Allergy: European Journal of Allergy and Clinical Immunology vol. 70, (6) 720-724.
10.1111/all.12607
Dodev TS, Karagiannis P, Gilbert AE, Josephs DH, Bowen H, James LK, Bax HJ, Beavil R et al.(2014). A tool kit for rapid cloning and expression of recombinant antibodies. Scientific Reports vol. 4,
10.1038/srep05885
Wu YCB, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ(2014). Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis. Journal of Allergy and Clinical Immunology vol. 134, (3) 604-612.
10.1016/j.jaci.2014.07.010
James LK, Bowen H, Calvert RA, Dodev TS, Shamji MH, Beavil AJ, McDonnell JM, Durham SR et al.(2012). Allergen specificity of IgG<inf>4</inf>-expressing B cells in patients with grass pollen allergy undergoing immunotherapy. Journal of Allergy and Clinical Immunology vol. 130, (3)
10.1016/j.jaci.2012.04.006
Shamji MH, James LK, Durham SR(2011). Serum Immunologic Markers for Monitoring Allergen-Specific Immunotherapy. Immunology and Allergy Clinics of North America vol. 31, (2) 311-323.
10.1016/j.iac.2011.03.005
James LK, Shamji MH, Walker SM, Wilson DR, Wachholz PA, Francis JN, Jacobson MR, Kimber I et al.(2011). Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. Journal of Allergy and Clinical Immunology vol. 127, (2)
10.1016/j.jaci.2010.12.1080
James LK, Durham SR(2009). Rhinitis with negative skin tests and absent serum allergen-specific IgE: More evidence for local IgE?. Journal of Allergy and Clinical Immunology vol. 124, (5) 1012-1013.
10.1016/j.jaci.2009.09.029
Thrower SL, James L, Hall W, Green KM, Arif S, Allen JS, Van-Krinks C, Lozanoska-Ochser B et al.(2009). Proinsulin peptide immunotherapy in type 1 diabetes: Report of a first-in-man Phase I safety study. Clinical and Experimental Immunology vol. 155, (2) 156-165.
10.1111/j.1365-2249.2008.03814.x
James LK, Durham SR(2008). Update on mechanisms of allergen injection immunotherapy. Clinical and Experimental Allergy vol. 38, (7) 1074-1088.
10.1111/j.1365-2222.2008.02976.x
Francis JN, James LK, Paraskevopoulos G, Wong C, Calderon MA, Durham SR, Till SJ(2008). Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. Journal of Allergy and Clinical Immunology vol. 121, (5)
10.1016/j.jaci.2008.01.072
Wiggam S, James L, Arif S, Peakman M, Dayan C (2007). Proinsulin peptide administration: A phase 1 study initial report. ACTA DIABETOLOGICA. vol. 44, S55-S55.
Pilette C, Nouri-Aria KT, Jacobson MR, Wilcock LK, Detry B, Walker SM, Francis JN, Durham SR(2007). Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-β expression. Journal of Immunology vol. 178, (7) 4658-4666.
10.4049/jimmunol.178.7.4658
Senna G, Passalacqua G, Schiappoli M, Lombardi C, Wilcock L(2007). Correlation among FEV, nitric oxide and asthma control test in newly diagnosed asthma. Allergy vol. 62, (2) 207-208.
10.1111/j.1398-9995.2006.01250.x
Shamji MH, Wilcock LK, Wachholz PA, Dearman RJ, Kimber I, Wurtzen PA, Larché M, Durham SR et al.(2006). The IgE-facilitated allergen binding (FAB) assay: Validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses. Journal of Immunological Methods vol. 317, (1-2) 71-79.
10.1016/j.jim.2006.09.004
Wilcock LK, Francis JN, Paraskevopolous G, Till SJ, Durham SR (2006). Induction and maintenance of regulatory humoral responses during grass pollen immunotherapy. CLINICAL AND EXPERIMENTAL ALLERGY. vol. 36, 1205-1205.
Wilcock LK, Francis JN, Durham SR(2006). IgE-Facilitated Antigen Presentation: Role in Allergy and the Influence of Allergen Immunotherapy. Immunology and Allergy Clinics of North America vol. 26, (2) 333-347.
10.1016/j.iac.2006.02.004
Wilcock LK, Francis JN, Paraskavopoulos G, Till SJ, Durham SR (2006). Induction of IL-10 occurs early and precedes serum IgG blocking activity during a cluster regimen of grass pollen immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. vol. 117, S330-S330.
10.1016/j.jaci.2005.12.1300
Shamji MH, Wilcock LK, Larche M, Francis JN, Durham SR (2006). Validation of a functional assay of IgE-facilitated CD23-dependent allergen binding to B cells to monitor clinical efficacy of immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. vol. 117, S330-S330.
10.1016/j.jaci.2005.12.1301
Shamji M, Wilcock L, Larche M, Durham S, Francis J (2005). Analytical validation of a novel flow cytometric-based Facilitated Allergen Presentation (FAP) assay as a tool for monitoring allergen-specific immunotherapy. CLINICAL AND EXPERIMENTAL ALLERGY. vol. 35, 1415-1415.
Francis J, Wilcock L, Puggioni F, Durham S (2004). Adjuvants in allergy immunotherapy; comparison of in vitro responses to old and new adjuvants. CLINICAL AND EXPERIMENTAL ALLERGY. vol. 34, 1810-1810.
Wilcock LK, Francis JN, Durham SR(2004). Aluminium hydroxide down-regulates T helper 2 responses by allergen-stimulated human peripheral blood mononuclear cells. Clinical and Experimental Allergy vol. 34, (9) 1373-1378.
10.1111/j.1365-2222.2004.02052.x
Nouri-Aria KT, Wachholz PA, Francis JN, Jacobson MR, Walker SM, Wilcock LK, Staple SQ, Aalberse RC et al.(2004). Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity. Journal of Immunology vol. 172, (5) 3252-3259.
10.4049/jimmunol.172.5.3252
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