Publications: Dr Louisa James

Liu J, Zhang K, Zhang X, Guan F, Zeng H, Kubo M, Lee P, Candotti F et al. ( 2024 ) . Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseases . MedComm vol. 5 , ( 8 )

Bessell E, Finlay RE, James LK, Ludewig B, Harris NL, Krebs P, Hepworth MR, Dubey LK ( 2024 ) . Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity . Cell Reports vol. 43 , ( 8 )

Humphreys DT, Lewis A, Pan‐Castillo B, Berti G, Mein C, Wozniak E, Gordon H, Gadhok R et al. ( 2024 ) . Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease . Journal of Cellular and Molecular Medicine vol. 28 , ( 9 )

D’Avola A, Legrave N, Tajan M, Chakravarty P, Shearer RL, King HW, Kluckova K, Cheung EC et al. ( 2024 ) . PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma . Journal of Clinical Investigation vol. 134 , ( 4 )

Alvarez RA, James LK ( 2024 ) . Decoding the language of immunity . Science vol. 383 , ( 6679 ) 146 - 147 .

Kariyawasam HH, James LK ( 2023 ) . Chronic rhinosinusitis with nasal polyps: eosinophils versus B lymphocytes in disease pathogenesis . Current Opinion in Allergy and Clinical Immunology vol. 24 , ( 1 ) 15 - 24 .

Tang J, Yang L, Guan F, Miller H, Camara NOS, James LK, Benlagha K, Kubo M et al. ( 2023 ) . The role of Raptor in lymphocytes differentiation and function . Frontiers in Immunology vol. 14 ,

Baker D, Forte E, Pryce G, Kang AS, James LK, Giovannoni G, Schmierer K ( 2022 ) . The impact of sphingosine-1-phosphate receptor modulators on COVID-19 and SARS-CoV-2 vaccination . Multiple Sclerosis and Related Disorders vol. 69 ,

James LK ( 2022 ) . B cells defined by immunoglobulin isotypes . Clinical & Experimental Immunology vol. 210 , ( 3 ) 230 - 239 .

Tan D, Yin W, Guan F, Zeng W, Lee P, Candotti F, James LK, Camara NOS et al. ( 2022 ) . B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions . Frontiers in Cell and Developmental Biology vol. 10 ,

Chen S, Guan F, Candotti F, Benlagha K, Camara NOS, Herrada AA, James LK, Lei J et al. ( 2022 ) . The role of B cells in COVID-19 infection and vaccination . Frontiers in Immunology vol. 13 ,

Conde CD, Xu C, Jarvis L, Rainbow D, Wells S, Gomes T, Howlett S, Suchanek O et al. ( 2022 ) . Cross-tissue immune cell analysis reveals tissue-specific features in humans . Science vol. 376 , ( 6594 ) eabl5197 - eabl5197 .

D'Avola A, Legrave N, Tajan M, Chakravarty P, Shearer RL, King HW, Kluckova K, Cheung EC et al. ( 2022 ) . PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma . Journal of Clinical Investigation vol. 132 , ( 9 )

Kleshchevnikov V, Shmatko A, Dann E, Aivazidis A, King HW, Li T, Elmentaite R, Lomakin A et al. ( 2022 ) . Cell2location maps fine-grained cell types in spatial transcriptomics . Nature Biotechnology vol. 40 , ( 5 ) 661 - 671 .

D'Avola A, Legrave N, Tajan M, Chakravarty P, Shearer R, King H, Cheung E, Clear AJ et al. ( 2021 ) . Phosphoglycerate Dehydrogenase Is Required for Germinal Center Formation and Is a Therapeutic Target in MYC- driven Lymphoma . Blood vol. 138 , ( Supplement 1 ) 717 - 717 .

King HW, Wells KL, Shipony Z, Kathiria AS, Wagar LE, Lareau C, Orban N, Capasso R et al. ( 2021 ) . Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci . Science Immunology vol. 6 , ( 64 )

McKendry RT, Kwok M, Hemmings O, James LK, Santos AF ( 2021 ) . Allergen‐specific IgG show distinct patterns in persistent and transient food allergy . Pediatric Allergy and Immunology vol. 32 , ( 7 ) 1508 - 1518 .

Kariyawasam HH, James LK ( 2021 ) . Do B cells rather than eosinophils drive chronic rhinosinusitis with nasal polyps? . The Lancet Respiratory Medicine vol. 9 , ( 10 )

Yang B, Dziadzio M, Meridamorillas M, Joseph JA, Gane SB, James LK, Kariyawasam HH ( 2021 ) . Chronic rhinosinusitis: Eosinophil blood reference values and decision limits and tissue count intravariability . Clinical Otolaryngology vol. 46 , ( 5 ) 1142 - 1145 .

Conde CD, Xu C, Jarvis L, Gomes T, Howlett S, Rainbow D, Suchanek O, King H et al. ( 2021 ) . Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture in humans .

Kariyawasam HH, James LK ( 2021 ) . B cells and upper airway disease: allergic rhinitis and chronic rhinosinusitis with nasal polyps evaluated . Expert Review of Clinical Immunology vol. 17 , ( 5 ) 445 - 459 .

King HW, Wells KL, Shipony Z, Kathiria AS, Wagar LE, Lareau C, Orban N, Capasso R et al. ( 2021 ) . Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci .

Hemmings O, Niazi U, Kwok M, James LK, Lack G, Santos AF ( 2021 ) . Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children . Journal of Allergy and Clinical Immunology vol. 148 , ( 2 ) 495 - 505.e14 .

King HW, Orban N, Riches JC, Clear AJ, Warnes G, Teichmann SA, James LK ( 2021 ) . Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics . Science Immunology vol. 6 , ( 56 )

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures . Frontiers in Immunology vol. 11 ,

Kariyawasam HH, James LK ( 2020 ) . Chronic Rhinosinusitis with Nasal Polyps: Targeting IgE with Anti-IgE Omalizumab Therapy . Drug Design Development and Therapy vol. 14 , 5483 - 5494 .

Herman LS, James LK ( 2020 ) . Moving with the kines: Chemokine receptor expression regulates the migration and differentiation of IgG4‐expressing B cells . European Journal of Immunology vol. 50 , ( 8 ) 1109 - 1112 .

Baker D, Pryce G, James LK, Marta M, Schmierer K ( 2020 ) . The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis . Multiple Sclerosis and Related Disorders Article 102279 , 102279 - 102279 .

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures .

Gould HJ, James LK ( 2020 ) . IgG+ memory B cells: Friends or foes in allergic disease? . Journal of Allergy and Clinical Immunology vol. 146 , ( 1 ) 77 - 79 .

Kariyawasam HH, James LK, Gane SB ( 2020 ) . Dupilumab: Clinical Efficacy of Blocking IL-4/IL-13 Signalling in Chronic Rhinosinusitis with Nasal Polyps . Drug Design Development and Therapy vol. 14 , 1757 - 1769 .

King HW, Orban N, Riches JC, Clear AJ, Warnes G, Teichmann SA, James LK ( 2020 ) . Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation .

Santos AF, Barbosa‐Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O’Rourke C, Bahnson HT et al. ( 2020 ) . IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2‐specific IgE . Allergy vol. 75 , ( 9 ) 2309 - 2318 .

James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR et al. ( 2020 ) . Distinct microbial and immune niches of the human colon . Nature Immunology vol. 21 , ( 3 ) 343 - 353 .

Baker D, Pryce G, James LK, Marta M, Schmierer K ( 2020 ) . The ocrelizumab phase II extension trial suggests the potential to improve the risk:benefit balance in multiple sclerosis . Multiple Sclerosis and Related Disorders2020.01.09.20016774 - 2020.01.09.20016774 .

Kleshchevnikov V, Shmatko A, Dann E, Aivazidis A, King HW, Li T, Lomakin A, Kedlian V et al. ( 2020 ) . Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics . bioRxiv

James K, Gomes T, Elmentaite R, Kumar N, Gulliver E, King H, Stares, Bareham B et al. ( 2019 ) . Distinct microbial and immune niches of the human colon .

Baker D, Pryce G, James LK, Schmierer K, Giovannoni G ( 2019 ) . Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis . European Journal of Neurology vol. 27 , ( 2 ) 221 - 228 .

Santos AF, James LK, Kwok M, McKendry RT, Anagnostou K, Clark AT, Lack G ( 2019 ) . Peanut oral immunotherapy induces blocking antibodies but does not change the functional characteristics of peanut-specific IgE . Journal of Allergy and Clinical Immunology vol. 145 , ( Allergy 64 2009 ) 440 - 443.e5 .

Bucaite G, Kang-Pettinger T, Moreira J, Gould HJ, James LK, Sutton BJ, McDonnell JM ( 2019 ) . Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies . The Journal of Immunology vol. 203 , ( 7 ) 1693 - 1700 .

Upton NEG, Hayday TS, James LK ( 2019 ) . Isolation and Characterization of Lymphocytes from Human Mucosal Biopsies . Allergy , vol. 2020 , Springer Nature

Gould HJ, James LK ( 2019 ) . Orchestration of immunoglobulin isotypes, subclasses, and specificities in patients receiving intravenous IgG or subcutaneous immunotherapy and those with chronic rhinosinusitis with nasal polyps: Toward precision medicine . Journal of Allergy and Clinical Immunology

Mckendry RT, Kwok M, Hemmings O, James L, Santos AF ( 2019 ) . Basophil and mast cell responses to food allergens in sensitised but tolerant patients are not mediated via the FcgRIIa and FcgRIIb receptors . ALLERGY . vol. 74 , 97 - 97 .

Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ et al. ( 2018 ) . Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition . Proceedings of the National Academy of Sciences of the United States of America vol. 115 , ( 37 ) E8707 - E8716 .

Dhaliwal B, Pang MOY, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ ( 2017 ) . IgE binds asymmetrically to its B cell receptor CD23 . Scientific Reports vol. 7 ,

Chen J-B, James LK, Davies AM, Wu Y-CB, Rimmer J, Lund VJ, Chen J-H, McDonnell JM et al. ( 2016 ) . Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps . Journal of Allergy and Clinical Immunology vol. 139 , ( 4 ) 1195 - 1204.e11 .

James LK, Till SJ ( 2016 ) . Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions . Current Allergy and Asthma Reports vol. 16 , ( 3 )

James LK ( 2016 ) . The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy . Current Allergy and Asthma Reports vol. 16 , ( 2 )

Steveling EH, Lao-Araya M, Koulias C, Scadding G, Eifan A, James LK, Dumitru A, Penagos M et al. ( 2015 ) . Protocol for a randomised, double‐blind, placebo‐controlled study of grass allergen immunotherapy tablet for seasonal allergic rhinitis: time course of nasal, cutaneous and immunological outcomes . Clinical and Translational Allergy vol. 5 , ( 1 )

Gadermaier E, James LK, Shamji MH, Blatt K, Fauland K, Zieglmayer P, Garmatiuk T, Focke-Tejkl M et al. ( 2015 ) . Epitope specificity determines cross‐protection of a SIT‐induced IgG4 antibody . Allergy vol. 71 , ( 1 ) 36 - 46 .

Mitropoulou AN, Davies AM, Dodev TS, James LK, Beavil RL, Gould HJ, McDonnell JM, Beavil AJ et al. ( 2015 ) . The crystal structure of a common allergen in complex with its specific patient-derived antibody . Acta Crystallographica Section A: Foundations and advances vol. 71 , ( a1 ) s259 - s259 .

Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM, Durham SR, Sutton BJ et al. ( 2015 ) . Inhibition of allergen‐dependent IgE activity by antibodies of the same specificity but different class . Allergy vol. 70 , ( 6 ) 720 - 724 .

Santos AF, James LK, Bahnson HT, Shamji MH, Couto-Francisco NC, Islam S, Houghton S, Clark AT et al. ( 2015 ) . IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens . Journal of Allergy and Clinical Immunology vol. 135 , ( 5 ) 1249 - 1256 .

Wu Y-CB, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ ( 2014 ) . Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis . Journal of Allergy and Clinical Immunology vol. 134 , ( 3 ) 604 - 612 .

Dodev TS, Karagiannis P, Gilbert AE, Josephs DH, Bowen H, James LK, Bax HJ, Beavil R et al. ( 2014 ) . A tool kit for rapid cloning and expression of recombinant antibodies . Scientific Reports vol. 4 , ( 1 )

James LK, Bowen H, Calvert RA, Dodev TS, Shamji MH, Beavil AJ, McDonnell JM, Durham SR et al. ( 2012 ) . Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy . Journal of Allergy and Clinical Immunology vol. 130 , ( 3 ) 663 - 670.e3 .

Shamji MH, James LK, Durham SR ( 2011 ) . Serum Immunologic Markers for Monitoring Allergen-Specific Immunotherapy . Immunology and Allergy Clinics of North America vol. 31 , ( 2 ) 311 - 323 .

James LK, Shamji MH, Walker SM, Wilson DR, Wachholz PA, Francis JN, Jacobson MR, Kimber I et al. ( 2011 ) . Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies . Journal of Allergy and Clinical Immunology vol. 127 , ( 2 ) 509 - 516.e5 .

James LK, Durham SR ( 2009 ) . Rhinitis with negative skin tests and absent serum allergen-specific IgE: More evidence for local IgE? . Journal of Allergy and Clinical Immunology vol. 124 , ( 5 ) 1012 - 1013 .

Thrower SL, James L, Hall W, Green KM, Arif S, Allen JS, Van-Krinks C, Lozanoska-Ochser B et al. ( 2008 ) . Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study . Clinical & Experimental Immunology vol. 155 , ( 2 ) 156 - 165 .

James LK, Durham SR ( 2008 ) . Update on mechanisms of allergen injection immunotherapy . Clinical & Experimental Allergy vol. 38 , ( 7 ) 1074 - 1088 .

Francis JN, James LK, Paraskevopoulos G, Wong C, Calderon MA, Durham SR, Till SJ ( 2008 ) . Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity . Journal of Allergy and Clinical Immunology vol. 121 , ( 5 ) 1120 - 1125.e2 .

Pilette C, Nouri-Aria KT, Jacobson MR, Wilcock LK, Detry B, Walker SM, Francis JN, Durham SR ( 2007 ) . Grass Pollen Immunotherapy Induces an Allergen-Specific IgA2 Antibody Response Associated with Mucosal TGF-β Expression . The Journal of Immunology vol. 178 , ( 7 ) 4658 - 4666 .

Senna G, Passalacqua G, Schiappoli M, Lombardi C, Wilcock L ( 2007 ) . Correlation among FEV1, nitric oxide and asthma control test in newly diagnosed asthma . Allergy vol. 62 , ( 2 ) 207 - 208 .

Wiggam S, James L, Arif S, Peakman M, Dayan C ( 2007 ) . Proinsulin peptide administration: A phase 1 study initial report . ACTA DIABETOLOGICA . vol. 44 , S55 - S55 .

Shamji MH, Wilcock LK, Wachholz PA, Dearman RJ, Kimber I, Wurtzen PA, Larché M, Durham SR et al. ( 2006 ) . The IgE-facilitated allergen binding (FAB) assay: Validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses . Journal of Immunological Methods vol. 317 , ( 1-2 ) 71 - 79 .

Wilcock LK, Francis JN, Durham SR ( 2006 ) . IgE-Facilitated Antigen Presentation: Role in Allergy and the Influence of Allergen Immunotherapy . Immunology and Allergy Clinics of North America vol. 26 , ( 2 ) 333 - 347 .

Wilcock LK, Francis JN, Paraskavopoulos G, Till SJ, Durham SR ( 2006 ) . Induction of IL-10 Occurs Early and Precedes Serum IgG Blocking Activity During a Cluster Regimen of Grass Pollen Immunotherapy . Journal of Allergy and Clinical Immunology . vol. 117 ,

Shamji MH, Wilcock LK, Larche M, Francis JN, Durham SR ( 2006 ) . Validation of a Functional Assay of IgE-Facilitated CD23-Dependent Allergen Binding to B Cells to Monitor Clinical Efficacy of Immunotherapy . Journal of Allergy and Clinical Immunology . vol. 117 ,

Wilcock LK, Francis JN, Paraskevopolous G, Till SJ, Durham SR ( 2006 ) . Induction and maintenance of regulatory humoral responses during grass pollen immunotherapy . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 36 , 1205 - 1205 .

Shamji M, Wilcock L, Larché M, Durham S, Francis J ( 2005 ) . Analytical validation of a novel flow cytometric-based Facilitated Allergen Presentation (FAP) assay as a tool for monitoring allergen-specific immunotherapy . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 35 , 1415 - 1415 .

Wilcock LK, Francis JN, Durham SR ( 2004 ) . Aluminium hydroxide down‐regulates T helper 2 responses by allergen‐stimulated human peripheral blood mononuclear cells . Clinical & Experimental Allergy vol. 34 , ( 9 ) 1373 - 1378 .

Nouri-Aria KT, Wachholz PA, Francis JN, Jacobson MR, Walker SM, Wilcock LK, Staple SQ, Aalberse RC et al. ( 2004 ) . Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity . The Journal of Immunology vol. 172 , ( 5 ) 3252 - 3259 .

Francis J, Wilcock L, Puggioni F, Durham S ( 2004 ) . Adjuvants in allergy immunotherapy;: comparison of <i>in vitro</i> responses to old and new adjuvants . CLINICAL AND EXPERIMENTAL ALLERGY . vol. 34 , 1810 - 1810 .