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Publications:  Dr Lesley Howell

Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA et al.(2020). Modulation of dopamine D<inf>1</inf> receptors via histamine H<inf>3</inf> receptors is a novel therapeutic target for Huntington's disease. eLife vol. 9,
Botta J, Bibic L, Killoran P, McCormick PJ, Howell LA(2019). Design and development of stapled transmembrane peptides that disrupt the activity of G-protein coupled receptor oligomers. J Biol Chem
Mills SC, HOWELL LA, Beekman A, Stokes L, Mueller A(2017). Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4. Cellular Signalling
HOWELL LA, Beekman A, O'Connell MA(2017). Peptide directed binding; a novel approach for the discovery of modulators of alpha-helix mediated protein-protein interactions demonstrated with apoptosis regulating Mcl-1. Angewandte Chemie International Edition
HOWELL LA, Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Resel E, Puente N et al.(2017). Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. Neuropsychopharmacology (Nature)
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ et al.(2016). Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure. Journal of Medicinal Chemistry vol. 59, (15) 7152-7166.
Beekman AM, O'Connell MA, Howell LA(2016). Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1). ChemMedChem vol. 11, (8) 840-844.
Beekman AM, Howell LA(2016). Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1. ChemMedChem vol. 11, (8) 802-813.
Angulo J, Goffin SA, Gandhi D, Searcey M, Howell LA(2016). Unveiling the "three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach. Chemistry - A European Journal vol. 22, (17) 5858-5862.
Austin MJ, Hearnshaw SJ, Mitchenall LA, McDermott PJ, Howell LA, Maxwell A, Searcey M(2016). A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents. MedChemComm vol. 7, (7) 1387-1391.
Cominetti MMD, Goffin SA, Raffel E, Turner KD, Ramoutar JC, O'Connell MA, Howell LA, Searcey M(2015). Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin. Bioorganic and Medicinal Chemistry Letters vol. 25, (21) 4878-4880.
Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, De La Torre R, Gasperini P, Navarro G et al.(2015). Cognitive impairment induced by delta9- tetrahydrocannabinol occurs through heteromers between cannabinoid CB<inf>1</inf> and serotonin 5-HT<inf>2A</inf> receptors. PLoS Biology vol. 13, (7)
Navarro G, Quiroz C, Moreno-Delgado D, Sierakowiak A, McDowell K, Moreno E, Rea W, Cai NS et al.(2015). Orexin–corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Journal of Neuroscience vol. 35, (17) 6639-6653.
Waller ZAE, Howell LA, Macdonald CJ, O'Connell MA, Searcey M(2014). Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Biochemical and Biophysical Research Communications vol. 447, (1) 128-132.
Rackham BD, Howell LA, Round AN, Searcey M(2013). Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy. Organic and Biomolecular Chemistry vol. 11, (48) 8340-8347.
Marín MJ, Rackham BD, Round AN, Howell LA, Russell DA, Searcey M(2013). A rapid screen for molecules that form duplex to duplex crosslinks in DNA. Chemical Communications vol. 49, (80) 9113-9115.
Howell LA, Bowater RA, O'Connell MA, Reszka AP, Neidle S, Searcey M(2012). Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry. ChemMedChem vol. 7, (5) 792-804.
Howell LA, Waller ZAE, Bowater R, O'Connell M, Searcey M(2011). A small molecule that induces assembly of a four way DNA junction at low temperature. Chemical Communications vol. 47, (29) 8262-8264.
Howell LA, Gulam R, Mueller A, O'Connell MA, Searcey M(2010). Design and synthesis of threading intercalators to target DNA. Bioorganic and Medicinal Chemistry Letters vol. 20, (23) 6956-6959.
Howell LA, Howman A, O'Connell MA, Mueller A, Searcey M(2009). Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. Bioorganic and Medicinal Chemistry Letters vol. 19, (20) 5880-5883.
Howell LA, Searcey M(2009). Targeting higher-order DNA: Beyond the G-quadruplex. ChemBioChem vol. 10, (13) 2139-2143.
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