Publications: Dr Faraz Mardakheh
Dodel M, Guiducci G, Dermit M, Krishnamurthy S, Alard EL, Capraro F, Rekad Z, Stojic L et al.
(
2024
)
.
TREX reveals proteins that bind to specific RNA regions in living cells
.
Nature Methods1
-
12
.
Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B et al.
(
2023
)
.
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus
.
Nature Cell Biology
vol.
25
,
(
6
)
892
-
903
.
Azman MS, Alard EL, Dodel M, Capraro F, Faraway R, Dermit M, Fan W, Chakraborty A et al.
(
2023
)
.
An ERK1/2‐driven RNA‐binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene
.
The EMBO Journal
vol.
42
,
(
11
)
Mardakheh FK, Auciello G, Dafforn TR, Rappoport JZ, Heath JK
(
2023
)
.
Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation
.
Molecular and Cellular Biology
vol.
30
,
(
24
)
5672
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5685
.
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B et al.
(
2022
)
.
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
.
Development
vol.
149
,
(
13
)
Davidson K, Grevitt P, Contreras-Gerenas MF, Bridge KS, Hermida M, Shah KM, Mardakheh FK, Stubbs M et al.
(
2021
)
.
Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
.
Cell Death & Disease
vol.
12
,
(
11
)
Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K et al.
(
2021
)
.
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence
.
Nature Communications
Mendoza MB, Gutierrez S, Ortiz R, Moreno DF, Dermit M, Dodel M, Rebollo E, Bosch M et al.
(
2021
)
.
The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines
.
Science Signaling
vol.
14
,
(
691
)
Maiques O, Fanshawe B, Crosas-Molist E, Rodriguez-Hernandez I, Volpe A, Cantelli G, Boehme L, Orgaz JL et al.
(
2021
)
.
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
.
British Journal of Cancer
vol.
125
,
(
5
)
699
-
713
.
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen HCB et al.
(
2021
)
.
A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements
.
Science
vol.
372
,
(
6543
)
Dermit M, Mardakheh FK
(
2021
)
.
Purification and quantitative proteomic analysis of cell bodies and protrusions
.
STAR Protocols
vol.
2
,
(
2
)
Adams SD, Csere J, D’angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM et al.
(
2021
)
.
Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
.
Current Biology
vol.
31
,
(
7
)
1403
-
1416.e7
.
Coetzee AS, Carter EP, Milton CI, Heward JA, Uluyur F, Miao J, Mardakheh FK, Wang Y et al.
(
2020
)
.
Targeting FGFR signalling to disrupt cellular cross-talk in pancreatic cancer
.
Pancreatology
vol.
20
,
(
8
)
e19
-
e19
.
DERMIT M, Dodel M, Lee F, Azman M, Schwenzer H, Jones JJL, Blagden S, Ule J et al.
(
2020
)
.
Subcellular mRNA localization regulates ribosome biogenesis in migrating cells
.
Developmental Cell
vol.
55
,
(
3
)
298
-
313
.
Yu J, Navickas A, Asgharian H, Culbertson B, Fish L, Garcia K, Olegario JP, Dermit M et al.
(
2020
)
.
RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon
.
Cancer Discovery
vol.
10
,
(
9
)
1410
-
1423
.
Adams SD, Csere J, D’angelo G, Carter EP, Arnandis T, Dodel M, Kocher H, Grose R et al.
(
2020
)
.
Centrosome amplification mediates small extracellular vesicles secretion via lysosome disruption
.
Hau HTA, Ogundele O, Hibbert AH, Monfries CAL, Exelby K, Wood NJ, Nevarez-Mejia J, Carbajal MA et al.
(
2020
)
.
Maternal Larp6 controls oocyte development, chorion formation and elevation
.
Development (Cambridge)
vol.
147
,
(
4
)
Coetzee A, Carter E, Heward J, Mardakheh F, Grose R, Kocher H
(
2019
)
.
Abstract 5170: Targeting FGFR signaling to disrupt cellular cross-talk in pancreatic cancer
.
Cancer Research
.
vol.
79
,
5170
-
5170
.
Touat M, Sourisseau T, Dorvault N, Chabanon RM, Garrido M, Morel D, Krastev DB, Bigot L et al.
(
2018
)
.
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade
.
Journal of Clinical Investigation
vol.
128
,
(
4
)
1671
-
1687
.
Mardakheh FK
(
2017
)
.
Mass Spectrometry Analysis of Spatial Protein Networks by Colocalization Analysis (COLA)
.
Kinase Signaling Networks
,
vol.
1636
,
Springer Nature
Dermit M, Dodel M, Mardakheh FK
(
2017
)
.
Methods for monitoring and measurement of protein translation in time and space
.
Molecular Omics
vol.
13
,
(
12
)
2477
-
2488
.
Mardakheh FK, Self A, Marshall CJ
(
2017
)
.
RHO binding to FAM65A regulates Golgi reorientation during cell migration
.
Development
vol.
144
,
(
1
)
e1.1
-
e1.1
.
Mardakheh FK, Self A, Marshall CJ
(
2016
)
.
RHO binding to FAM65A regulates Golgi reorientation during cell migration
.
J Cell Sci
vol.
129
,
(
24
)
4466
-
4479
.
Touat M, Olaussen K, Sourisseau T, Friboulet L, Dorvault N, Enot D, Bigot L, Pontoizeau C et al.
(
2016
)
.
154 NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear–mitochondrial crosstalk in ERCC1-deficient populations
.
European Journal of Cancer
.
vol.
69
,
Mardakheh FK, Sailem HZ, Kümper S, Tape CJ, McCully RR, Paul A, Anjomani-Virmouni S, Jørgensen C et al.
(
2016
)
.
Proteomics profiling of interactome dynamics by colocalisation analysis (COLA)
.
Mol Biosyst
vol.
13
,
(
1
)
92
-
105
.
Natrajan R, Sailem H, Mardakheh FK, Garcia MA, Tape CJ, Dowsett M, Bakal C, Yuan Y
(
2016
)
.
Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis
.
PLOS Medicine
vol.
13
,
(
2
)
Kümper S, Mardakheh FK, McCarthy A, Yeo M, Stamp GW, Paul A, Worboys J, Sadok A et al.
(
2016
)
.
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis
.
eLife
vol.
5
,
Mardakheh FK, Paul A, Kümper S, Sadok A, Paterson H, Mccarthy A, Yuan Y, Marshall CJ
(
2015
)
.
Global Analysis of mRNA, Translation, and Protein Localization: Local Translation Is a Key Regulator of Cell Protrusions
.
Developmental Cell
vol.
35
,
(
3
)
344
-
357
.
Sadok A, McCarthy A, Caldwell J, Collins I, Garrett MD, Yeo M, Hooper S, Sahai E et al.
(
2015
)
.
Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
.
Cancer Research
vol.
75
,
(
11
)
2272
-
2284
.
Mardakheh FK, Yekezare M, Machesky LM, Heath JK
(
2009
)
.
Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling
.
Journal of Cell Biology
vol.
187
,
(
2
)
265
-
277
.
Sweet SMM, Mardakheh FK, Ryan KJP, Langton AJ, Heath JK, Cooper HJ
(
2008
)
.
Targeted Online Liquid Chromatography Electron Capture Dissociation Mass Spectrometry for the Localization of Sites of in Vivo Phosphorylation in Human Sprouty2
.
Analytical Chemistry
vol.
80
,
(
17
)
6650
-
6657
.
Mardakheh FK, Yekezare M, Machesky LM, Heath JK
(
2008
)
.
SPRED redirects activated receptors to lysosomes via scaffolding protein NBR1
.
European Journal of Cancer Supplements
.
vol.
6
,
38
-
39
.
Akbarzadeh S, Wheldon LM, Sweet SMM, Talma S, Mardakheh FK, Heath JK
(
2008
)
.
The Deleted in Brachydactyly B Domain of ROR2 Is Required for Receptor Activation by Recruitment of Src
.
PLOS ONE
vol.
3
,
(
3
)