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  1. Queen Mary University of London
  2. Research
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Publications: Dr Kevin Rouault-Pierre

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Rouault-Pierre K ( 2024 ) . Succinyl-coenzyme A: a key metabolite and succinyl group donor in erythropoiesis . Haematologica
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al. ( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .
Choi IY, Ling JP, Zhang J, Helmenstine E, Walter W, Tsakiroglou P, Bergman RE, Philippe C et al. ( 2024 ) . The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts . Blood Advances vol. 8 , ( 15 ) 3961 - 3971 .
Philippe C, Jaud M, Féral K, Gay A, Van Den Berghe L, Farce M, Bousquet M, Pyronnet S et al. ( 2024 ) . Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy . Leukemia vol. 38 , ( 8 ) 1764 - 1776 .
Kaya F, Bewicke-Copley F, Izquierdo PC, Zheng J, Miettinen JJ, Khan N, Krizsán S, Saad JJ et al. ( 2023 ) . The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients . Blood vol. 142 , ( Supplement 1 )
Saunderson EA, Encabo HH, Devis J, Rouault-Pierre K, Piganeau M, Bell CG, Gribben JG, Bonnet D et al. ( 2023 ) . CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny . Proceedings of the National Academy of Sciences of the United States of America vol. 120 , ( 34 )
Philippe C, Mian S, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al. ( 2023 ) . O20 TARGETING THE DEFECTIVE COA PATHWAY TO IMPROVE ERYTHROPOIESIS IN SF3B1-MUTANT MDS-RS PATIENTS . Leukemia Research vol. 128 ,
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS et al. ( 2023 ) . Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death . Nature Communications vol. 14 , ( 1 )
Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al. ( 2023 ) . Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia . Science Translational Medicine vol. 15 , ( 685 ) eabn5135 - eabn5135 .
Casado P, Rio-Machin A, Miettinen JJ, Bewicke-Copley F, Rouault-Pierre K, Krizsan S, Parsons A, Rajeeve V et al. ( 2023 ) . Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes . Signal Transduction and Targeted Therapy vol. 8 , ( 1 )
Berastegui N, Ainciburu M, Romero JP, Garcia-Olloqui P, Alfonso-Pierola A, Philippe C, Vilas-Zornoza A, San Martin-Uriz P et al. ( 2022 ) . The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes . Nature Communications vol. 13 , ( 1 )
Rio-Machin A, Bewicke-Copley F, Zheng J, Izquierdo PC, Miettinen JJ, Khan N, Demeulemeester J, Krizsán S et al. ( 2022 ) . Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML . Blood vol. 140 , ( Supplement 1 ) 1030 - 1032 .
Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al. ( 2022 ) . Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia . Blood vol. 140 , ( Supplement 1 ) 3058 - 3060 .
Armes H, Bewicke‐Copley F, Rio‐Machin A, Di Bella D, Philippe C, Wozniak A, Tummala H, Wang J et al. ( 2022 ) . Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment . British Journal of Haematology vol. 199 , ( 5 ) 754 - 764 .
Hug N, Aitken S, Longman D, Raab M, Armes H, Mann AR, Rio-Machin A, Fitzgibbon J et al. ( 2022 ) . A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation . RNA vol. 28 , ( 9 )
Saunderson E, Encabo H, Rouault‐Pierre K, Piganeau M, Bonnet D, Gribben J, Ficz G ( 2022 ) . P1411: DUAL EPIGENETIC AND GENETIC EDITING OF PRIMARY HUMAN HAEMATOPOIETIC STEM AND PROGENITOR CELLS . HemaSphere vol. 6 , ( Suppl ) 1295 - 1296 .
Pedicona F, Casado P, Hijazi M, Gribben JG, Rouault-Pierre K, Cutillas PR ( 2022 ) . Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment . Science Signaling vol. 15 , ( 730 )
Armes H, Rio-Machin A, Krizsán S, Bödör C, Kaya F, Bewicke-Copley F, Alnajar J, Walne A et al. ( 2022 ) . Acquired somatic variants in inherited myeloid malignancies . Leukemia vol. 36 , ( 5 ) 1377 - 1381 .
Armes H, Rio-Machin A, Krizsan S, Bodor C, Kaya F, Bewicke-Copley F, Alnajar J, Walne A et al. ( 2022 ) . Acquired somatic variants in inherited myeloid malignancies . LEUKEMIA vol. 36 , ( 5 ) 1377 - 1381 .
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Tzelepis K, Philippe C, Rattigan K, Asby R et al. ( 2021 ) . Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia . Blood vol. 138 , ( Supplement 1 )
Gurashi K, Weightman J, Baker SM, Rouault-Pierre K, Breitweister W, Somervaille TCP, Batta K, Wiseman DH ( 2021 ) . Multiomic Single-Cell Sequencing Reveals Patterns of Disease Evolution and Acute Transformation in Chronic Myelomonocytic Leukaemia . Blood vol. 138 , ( Supplement 1 )
Mian S, Philippe C, Maniati E, Bergot T, Piganeau M, Di Bella D, Morales V, Finch A et al. ( 2021 ) . Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia . Blood vol. 138 , ( Supplement 1 )
Rouault‐Pierre K ( 2021 ) . Splicing Factor Mutations and Disease Phenotype: Searching for a Needle in a Haystack . HemaSphere vol. 5 , ( 6 )
Féral K, Jaud M, Philippe C, Di Bella D, Pyronnet S, Rouault-Pierre K, Mazzolini L, Touriol C ( 2021 ) . ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both? . Biomolecules vol. 11 , ( 2 )
Rosu A, Hachem NE, Rapino F, Rouault-Pierre K, Jorssen J, Somja J, Ramery E, Thiry M et al. ( 2021 ) . Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis . Journal of Experimental Medicine vol. 218 , ( 3 )
Mian SA, Abarrategi A, Kong KL, Rouault-Pierre K, Wood H, Oedekoven CA, Smith AE, Batsivari A et al. ( 2020 ) . Ectopic Humanized Mesenchymal Niche in Mice Enables Robust Engraftment of Myelodysplastic Stem CellsHumanized Niches Support Myelodysplastic Stem Cells . Blood Cancer Discovery vol. 2 , ( 2 ) 135 - 145 .
Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al. ( 2020 ) . Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia . Blood vol. 136 , ( Supplement 1 ) 39 - 40 .
Waclawiczek A, Hamilton A, Rouault-Pierre K, Abarrategi A, Albornoz MG, Miraki-Moud F, Bah N, Gribben J et al. ( 2020 ) . Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia . Journal of Clinical Investigation vol. 130 , ( 6 ) 3038 - 3050 .
Jaud M, Philippe C, Di Bella D, Tang W, Pyronnet S, Laurell H, Mazzolini L, Rouault-Pierre K et al. ( 2020 ) . Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers . Cells vol. 9 , ( 3 )
Caye A, Rouault-Pierre K, Strullu M, Lainey E, Abarrategi A, Fenneteau O, Arfeuille C, Osman J et al. ( 2020 ) . Correction: Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment . Leukemia vol. 34 , ( 7 ) 1973 - 1973 .
Ezponda T, Berastegui N, Romero JP, Ainciburu M, Alfonso A, Vilas-Zornoza A, Vilas-ZornozaSan MP, Castro L et al. ( 2020 ) . ROLE OF TRANSCRIPTIONAL ALTERATIONS IN HEMATOPOIETIC STEM CELL REGULATION DURING AGING AND IN THE PATHOGENESIS OF MYELODYSPLASTIC SYNDROMES . HAEMATOLOGICA . vol. 105 , 69 - 69 .
Caye A, Rouault-Pierre K, Strullu M, Lainey E, Abarrategi A, Fenneteau O, Arfeuille C, Osman J et al. ( 2019 ) . Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment . Leukemia vol. 34 , ( 6 ) 1658 - 1668 .
Saunderson EA, Rouault-Pierre K, Gribben JG, Ficz G ( 2019 ) . CRISPR/Cas9-Targeted De Novo DNA Methylation Is Maintained and Impacts the Colony Forming Potential of Human Hematopoietic CD34+ Cells . Blood vol. 134 , ( Supplement_1 )
Abarrategi A, Gambera S, Alfranca A, Rodriguez-Milla MA, Perez-Tavarez R, Rouault-Pierre K, Waclawiczek A, Chakravarty P et al. ( 2018 ) . c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells . Scientific Reports vol. 8 , ( 1 )
Abarrategi A, Mian SA, Passaro D, Rouault-Pierre K, Grey W, Bonnet D ( 2018 ) . Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches . Journal of Experimental Medicine vol. 215 , ( 3 ) 729 - 743 .
Di Tullio A, Rouault-Pierre K, Abarrategi A, Mian S, Grey W, Gribben J, Stewart A, Blackwood E et al. ( 2017 ) . The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia . Nat Commun vol. 8 , ( 1 ) 1679 - 1679 .
Mian S, Rouault-Pierre K, Goulard M, Fenaux P, Dosquet C, Mufti G, Bonnet D ( 2017 ) . Preclinical modeling of myelodysplastic syndromes . Experimental Hematology vol. 53 ,
Waclawiczek A, Hamilton A, Rouault-Pierre K, Abarrategi A, Bonnet D ( 2017 ) . Regulation of human stem and progenitor cells by acute myeloid leukaemia in the human niche . Experimental Hematology vol. 53 ,
Passaro D, Di Tullio A, Abarrategi A, Rouault-Pierre K, Foster K, Ariza-McNaughton L, Montaner B, Chakravarty P et al. ( 2017 ) . Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia . Cancer Cell vol. 32 , ( 3 ) 324 - 341.e6 .
Das A, Rouault-Pierre K, Kamdar S, Gomez-Tourino I, Wood K, Donaldson I, Mein CA, Bonnet D et al. ( 2017 ) . Adaptive from Innate: Human IFN-γ+CD4+T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults . J Immunol vol. 199 , ( 5 ) 1696 - 1705 .
Di Tullio A, Passaro D, Rouault-Pierre K, Purewal S, Bonnet D ( 2017 ) . Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation . Stem Cell Reports vol. 9 , ( 1 ) 5 - 11 .
Rouault-Pierre K, Mian SA, Goulard M, Abarrategi A, Di Tulio A, Smith AE, Mohamedali A, Best S et al. ( 2017 ) . Preclinical modeling of myelodysplastic syndromes . Leukemia vol. 31 , ( 12 ) 2702 - 2708 .
Passaro D, Di Tullio A, Abarrategi A, Rouault-Pierre K, Foster K, Ariza-McNaughton L, Chakravarty P, Bhaw L et al. ( 2017 ) . ACUTE MYELOID LEUKEMIA ALTERS THE PERMEABILITY OF THE BONE MARROW VASCULAR MICROENVIRONMENT, FOSTERING DISEASE PROGRESSION AND DRUG RESISTANCE . HAEMATOLOGICA . vol. 102 , 78 - 78 .
Mian SA, Rouault-Pierre K, Smith AE, Abarrategi A, Coats T, McLornan D, Mufti G, Bonnet D ( 2017 ) . Bone Marrow Stem Cells from Patients with Myelodysplastic Syndrome (MDS) Engraft and Migrate in-between the Humanized Niches in Immuno-Compromised Mouse Models . BLOOD . vol. 130 ,
Passaro D, Di Tullio A, Abarrategi A, Rouault-Pierre K, Foster K, McNaughton LA, Lassailly F, Bonnet D ( 2016 ) . Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Acute Myeloid Leukemia Progression and Drug Response . Blood . vol. 128 ,
Rouault-Pierre K, Smith AE, Mian SA, Pizzitola I, Kulasekararaj AG, Mufti GJ, Bonnet D ( 2016 ) . Myelodysplastic syndrome can propagate from the multipotent progenitor compartment . Haematologica vol. 102 , ( 1 ) e7 - e10 .
Rouault-Pierre K, Hamilton A, Bonnet D ( 2016 ) . Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact . Expert Opinion on Biological Therapy vol. 16 , ( 4 ) 463 - 476 .
Mian SA, Rouault-Pierre K, Smith AE, Seidl T, Pizzitola I, Kizilors A, Kulasekararaj AG, Bonnet D et al. ( 2015 ) . SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment . Nature Communications vol. 6 , ( 1 )
Foster K, Lassailly F, Anjos-Afonso F, Currie E, Rouault-Pierre K, Bonnet D ( 2015 ) . Different Motile Behaviors of Human Hematopoietic Stem versus Progenitor Cells at the Osteoblastic Niche . Stem Cell Reports vol. 5 , ( 5 ) 690 - 701 .
Tettamanti S, Pizzitola I, Marin V, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Spinelli O, Biondi A et al. ( 2015 ) . Chimeric Antigen Receptors for Specific Targeting of Acute Myeloid Leukemia . ANNALS OF HEMATOLOGY . vol. 94 , S55 - S56 .
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Spinelli O, Biondi A, Biagi E et al. ( 2014 ) . Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo . Leukemia vol. 28 , ( 8 ) 1596 - 1605 .
Griessinger E, Anjos-Afonso F, Pizzitola I, Rouault-Pierre K, Vargaftig J, Taussig D, Gribben J, Lassailly F et al. ( 2014 ) . A Niche‐Like Culture System Allowing the Maintenance of Primary Human Acute Myeloid Leukemia‐Initiating Cells: A New Tool to Decipher Their Chemoresistance and Self‐Renewal Mechanisms . Stem Cells Translational Medicine vol. 3 , ( 4 ) 520 - 529 .
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Biondi A, Biagi E, Bonnet D ( 2014 ) . Chimeric Antigen Receptor for Specific Targeting of Acute Myeloid Leukaemia . JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY . vol. 36 , 324 - 325 .
Das A, Furness C, White A, Hayday T, Rouault-Pierre K, Greaves M, Hayday AC, Gibbons DL ( 2014 ) . T-cell production of interleukin-8 (CXCL8) is enriched in recent thymic emigrants . IMMUNOLOGY . vol. 143 , 46 - 47 .
Mian SA, Rouault-Pierre K, Smith AE, Seidl T, Kulasekararaj AG, Mohamedali AM, Shinde S, Bonnet D et al. ( 2013 ) . SF3B1 Mutant Clones From Patients With Refractory Anaemia With Ringed Sideroblasts (RARS) Originate From The Early Haematopoietic Stem Cells and Maintain Their Engraftment Potential . Blood . vol. 122 ,
Rouault-Pierre K, Lopez-Onieva L, Foster K, Anjos-Afonso F, Lamrissi-Garcia I, Serrano-Sanchez M, Mitter R, Ivanovic Z et al. ( 2013 ) . HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress . Cell Stem Cell vol. 13 , ( 5 ) 549 - 563 .
Rouault-Pierre K, Lopez-Onieva L, Foster K, Anjos-Afonso F, Lamrissi-Garcia I, Serrano-Sanchez M, Mitter R, Ivanovic Z et al. ( 2013 ) . HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress . Cell Stem Cell vol. 13 , ( 5 ) 549 - 563 .
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Biondi A, Biagi E, Bonnet D ( 2013 ) . Chimeric antigen receptor for specific targeting of acute myeloid leukemia . Cytotherapy . vol. 15 ,
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Biondi A, Biagi E, Bonnet D ( 2013 ) . CHIMERIC ANTIGEN RECEPTOR FOR SPECIFIC TARGETING OF ACUTE MYELOID LEUKAEMIA . PEDIATRIC BLOOD & CANCER . vol. 60 , 29 - 29 .
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Biondi A, Biagi E, Bonnet D ( 2012 ) . Chimeric Antigen Receptor for Specific Targeting of Acute Myeloid Leukemia . Blood . vol. 120 ,
Rouault-Pierre K, Lopez-Onieva L, Rezvani H, Anjos-Afonso F, Lamrissi-Garcia I, Vlaski M, De Verneuil H, Ivanovic Z et al. ( 2012 ) . HYPOXIA-INDUCIBLE FACTOR 1A IS IMPORTANT TO MAINTAIN HUMAN HSC, BUT HIF-2A IS ESSENTIAL TO PROTECT THEM FROM ROS INDUCED APOPTOSIS . EXPERIMENTAL HEMATOLOGY . vol. 40 , S102 - S103 .
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