Publications: Dr Kevin Rouault-Pierre
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al.
(
2024
)
.
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation
.
Leukemia1
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15
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Choi IY, Ling JP, Zhang J, Helmenstine E, Walter W, Tsakiroglou P, Bergman RE, Philippe C et al.
(
2024
)
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The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
.
Blood Advances
vol.
8
,
(
15
)
3961
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3971
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Philippe C, Jaud M, Féral K, Gay A, Van Den Berghe L, Farce M, Bousquet M, Pyronnet S et al.
(
2024
)
.
Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy
.
Leukemia
vol.
38
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8
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1764
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1776
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Kaya F, Bewicke-Copley F, Izquierdo PC, Zheng J, Miettinen JJ, Khan N, Krizsán S, Saad JJ et al.
(
2023
)
.
The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients
.
Blood
vol.
142
,
(
Supplement 1
)
Saunderson EA, Encabo HH, Devis J, Rouault-Pierre K, Piganeau M, Bell CG, Gribben JG, Bonnet D et al.
(
2023
)
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CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
120
,
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34
)
Philippe C, Mian S, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al.
(
2023
)
.
O20 TARGETING THE DEFECTIVE COA PATHWAY TO IMPROVE ERYTHROPOIESIS IN SF3B1-MUTANT MDS-RS PATIENTS
.
Leukemia Research
vol.
128
,
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS et al.
(
2023
)
.
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
.
Nature Communications
vol.
14
,
(
1
)
Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D et al.
(
2023
)
.
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia
.
Science Translational Medicine
vol.
15
,
(
685
)
eabn5135
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eabn5135
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Casado P, Rio-Machin A, Miettinen JJ, Bewicke-Copley F, Rouault-Pierre K, Krizsan S, Parsons A, Rajeeve V et al.
(
2023
)
.
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
.
Signal Transduction and Targeted Therapy
vol.
8
,
(
1
)
Berastegui N, Ainciburu M, Romero JP, Garcia-Olloqui P, Alfonso-Pierola A, Philippe C, Vilas-Zornoza A, San Martin-Uriz P et al.
(
2022
)
.
The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes
.
Nature Communications
vol.
13
,
(
1
)
Rio-Machin A, Bewicke-Copley F, Zheng J, Izquierdo PC, Miettinen JJ, Khan N, Demeulemeester J, Krizsán S et al.
(
2022
)
.
Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML
.
Blood
vol.
140
,
(
Supplement 1
)
1030
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1032
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Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al.
(
2022
)
.
Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia
.
Blood
vol.
140
,
(
Supplement 1
)
3058
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3060
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Armes H, Bewicke‐Copley F, Rio‐Machin A, Di Bella D, Philippe C, Wozniak A, Tummala H, Wang J et al.
(
2022
)
.
Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment
.
British Journal of Haematology
vol.
199
,
(
5
)
754
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764
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Hug N, Aitken S, Longman D, Raab M, Armes H, Mann AR, Rio-Machin A, Fitzgibbon J et al.
(
2022
)
.
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation
.
RNA
vol.
28
,
(
9
)
Saunderson E, Encabo H, Rouault‐Pierre K, Piganeau M, Bonnet D, Gribben J, Ficz G
(
2022
)
.
P1411: DUAL EPIGENETIC AND GENETIC EDITING OF PRIMARY HUMAN HAEMATOPOIETIC STEM AND PROGENITOR CELLS
.
HemaSphere
vol.
6
,
(
Suppl
)
1295
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1296
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Pedicona F, Casado P, Hijazi M, Gribben JG, Rouault-Pierre K, Cutillas PR
(
2022
)
.
Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment
.
Science Signaling
vol.
15
,
(
730
)
Armes H, Rio-Machin A, Krizsán S, Bödör C, Kaya F, Bewicke-Copley F, Alnajar J, Walne A et al.
(
2022
)
.
Acquired somatic variants in inherited myeloid malignancies
.
Leukemia
vol.
36
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(
5
)
1377
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1381
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Armes H, Rio-Machin A, Krizsan S, Bodor C, Kaya F, Bewicke-Copley F, Alnajar J, Walne A et al.
(
2022
)
.
Acquired somatic variants in inherited myeloid malignancies
.
LEUKEMIA
vol.
36
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(
5
)
1377
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1381
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Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Tzelepis K, Philippe C, Rattigan K, Asby R et al.
(
2021
)
.
Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia
.
Blood
vol.
138
,
(
Supplement 1
)
Gurashi K, Weightman J, Baker SM, Rouault-Pierre K, Breitweister W, Somervaille TCP, Batta K, Wiseman DH
(
2021
)
.
Multiomic Single-Cell Sequencing Reveals Patterns of Disease Evolution and Acute Transformation in Chronic Myelomonocytic Leukaemia
.
Blood
vol.
138
,
(
Supplement 1
)
Mian S, Philippe C, Maniati E, Bergot T, Piganeau M, Di Bella D, Morales V, Finch A et al.
(
2021
)
.
Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia
.
Blood
vol.
138
,
(
Supplement 1
)
Rouault‐Pierre K
(
2021
)
.
Splicing Factor Mutations and Disease Phenotype: Searching for a Needle in a Haystack
.
HemaSphere
vol.
5
,
(
6
)
Féral K, Jaud M, Philippe C, Di Bella D, Pyronnet S, Rouault-Pierre K, Mazzolini L, Touriol C
(
2021
)
.
ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both?
.
Biomolecules
vol.
11
,
(
2
)
Rosu A, Hachem NE, Rapino F, Rouault-Pierre K, Jorssen J, Somja J, Ramery E, Thiry M et al.
(
2021
)
.
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis
.
Journal of Experimental Medicine
vol.
218
,
(
3
)
Mian SA, Abarrategi A, Kong KL, Rouault-Pierre K, Wood H, Oedekoven CA, Smith AE, Batsivari A et al.
(
2020
)
.
Ectopic Humanized Mesenchymal Niche in Mice Enables Robust Engraftment of Myelodysplastic Stem CellsHumanized Niches Support Myelodysplastic Stem Cells
.
Blood Cancer Discovery
vol.
2
,
(
2
)
135
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145
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Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al.
(
2020
)
.
Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia
.
Blood
vol.
136
,
(
Supplement 1
)
39
-
40
.
Waclawiczek A, Hamilton A, Rouault-Pierre K, Abarrategi A, Albornoz MG, Miraki-Moud F, Bah N, Gribben J et al.
(
2020
)
.
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia
.
Journal of Clinical Investigation
vol.
130
,
(
6
)
3038
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3050
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Jaud M, Philippe C, Di Bella D, Tang W, Pyronnet S, Laurell H, Mazzolini L, Rouault-Pierre K et al.
(
2020
)
.
Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers
.
Cells
vol.
9
,
(
3
)
Caye A, Rouault-Pierre K, Strullu M, Lainey E, Abarrategi A, Fenneteau O, Arfeuille C, Osman J et al.
(
2020
)
.
Correction: Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment
.
Leukemia
vol.
34
,
(
7
)
1973
-
1973
.
Ezponda T, Berastegui N, Romero JP, Ainciburu M, Alfonso A, Vilas-Zornoza A, Vilas-ZornozaSan MP, Castro L et al.
(
2020
)
.
ROLE OF TRANSCRIPTIONAL ALTERATIONS IN HEMATOPOIETIC STEM CELL REGULATION DURING AGING AND IN THE PATHOGENESIS OF MYELODYSPLASTIC SYNDROMES
.
HAEMATOLOGICA
.
vol.
105
,
69
-
69
.
Caye A, Rouault-Pierre K, Strullu M, Lainey E, Abarrategi A, Fenneteau O, Arfeuille C, Osman J et al.
(
2019
)
.
Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment
.
Leukemia
vol.
34
,
(
6
)
1658
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1668
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Saunderson EA, Rouault-Pierre K, Gribben JG, Ficz G
(
2019
)
.
CRISPR/Cas9-Targeted De Novo DNA Methylation Is Maintained and Impacts the Colony Forming Potential of Human Hematopoietic CD34+ Cells
.
Blood
vol.
134
,
(
Supplement_1
)
Abarrategi A, Gambera S, Alfranca A, Rodriguez-Milla MA, Perez-Tavarez R, Rouault-Pierre K, Waclawiczek A, Chakravarty P et al.
(
2018
)
.
c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells
.
Scientific Reports
vol.
8
,
(
1
)
Abarrategi A, Mian SA, Passaro D, Rouault-Pierre K, Grey W, Bonnet D
(
2018
)
.
Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches
.
Journal of Experimental Medicine
vol.
215
,
(
3
)
729
-
743
.
Di Tullio A, Rouault-Pierre K, Abarrategi A, Mian S, Grey W, Gribben J, Stewart A, Blackwood E et al.
(
2017
)
.
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
.
Nat Commun
vol.
8
,
(
1
)
1679
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1679
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Mian S, Rouault-Pierre K, Goulard M, Fenaux P, Dosquet C, Mufti G, Bonnet D
(
2017
)
.
Preclinical modeling of myelodysplastic syndromes
.
Experimental Hematology
vol.
53
,
Waclawiczek A, Hamilton A, Rouault-Pierre K, Abarrategi A, Bonnet D
(
2017
)
.
Regulation of human stem and progenitor cells by acute myeloid leukaemia in the human niche
.
Experimental Hematology
vol.
53
,
Passaro D, Di Tullio A, Abarrategi A, Rouault-Pierre K, Foster K, Ariza-McNaughton L, Montaner B, Chakravarty P et al.
(
2017
)
.
Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia
.
Cancer Cell
vol.
32
,
(
3
)
324
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341.e6
.
Das A, Rouault-Pierre K, Kamdar S, Gomez-Tourino I, Wood K, Donaldson I, Mein CA, Bonnet D et al.
(
2017
)
.
Adaptive from Innate: Human IFN-γ+CD4+T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults
.
J Immunol
vol.
199
,
(
5
)
1696
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1705
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Di Tullio A, Passaro D, Rouault-Pierre K, Purewal S, Bonnet D
(
2017
)
.
Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation
.
Stem Cell Reports
vol.
9
,
(
1
)
5
-
11
.
Rouault-Pierre K, Mian SA, Goulard M, Abarrategi A, Di Tulio A, Smith AE, Mohamedali A, Best S et al.
(
2017
)
.
Preclinical modeling of myelodysplastic syndromes
.
Leukemia
vol.
31
,
(
12
)
2702
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2708
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Passaro D, Di Tullio A, Abarrategi A, Rouault-Pierre K, Foster K, Ariza-McNaughton L, Chakravarty P, Bhaw L et al.
(
2017
)
.
ACUTE MYELOID LEUKEMIA ALTERS THE PERMEABILITY OF THE BONE MARROW VASCULAR MICROENVIRONMENT, FOSTERING DISEASE PROGRESSION AND DRUG RESISTANCE
.
HAEMATOLOGICA
.
vol.
102
,
78
-
78
.
Mian SA, Rouault-Pierre K, Smith AE, Abarrategi A, Coats T, McLornan D, Mufti G, Bonnet D
(
2017
)
.
Bone Marrow Stem Cells from Patients with Myelodysplastic Syndrome (MDS) Engraft and Migrate in-between the Humanized Niches in Immuno-Compromised Mouse Models
.
BLOOD
.
vol.
130
,
Passaro D, Di Tullio A, Abarrategi A, Rouault-Pierre K, Foster K, McNaughton LA, Lassailly F, Bonnet D
(
2016
)
.
Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Acute Myeloid Leukemia Progression and Drug Response
.
Blood
.
vol.
128
,
Rouault-Pierre K, Smith AE, Mian SA, Pizzitola I, Kulasekararaj AG, Mufti GJ, Bonnet D
(
2016
)
.
Myelodysplastic syndrome can propagate from the multipotent progenitor compartment
.
Haematologica
vol.
102
,
(
1
)
e7
-
e10
.
Rouault-Pierre K, Hamilton A, Bonnet D
(
2016
)
.
Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact
.
Expert Opinion on Biological Therapy
vol.
16
,
(
4
)
463
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476
.
Mian SA, Rouault-Pierre K, Smith AE, Seidl T, Pizzitola I, Kizilors A, Kulasekararaj AG, Bonnet D et al.
(
2015
)
.
SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment
.
Nature Communications
vol.
6
,
(
1
)
Foster K, Lassailly F, Anjos-Afonso F, Currie E, Rouault-Pierre K, Bonnet D
(
2015
)
.
Different Motile Behaviors of Human Hematopoietic Stem versus Progenitor Cells at the Osteoblastic Niche
.
Stem Cell Reports
vol.
5
,
(
5
)
690
-
701
.
Tettamanti S, Pizzitola I, Marin V, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Spinelli O, Biondi A et al.
(
2015
)
.
Chimeric Antigen Receptors for Specific Targeting of Acute Myeloid Leukemia
.
ANNALS OF HEMATOLOGY
.
vol.
94
,
S55
-
S56
.
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Spinelli O, Biondi A, Biagi E et al.
(
2014
)
.
Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo
.
Leukemia
vol.
28
,
(
8
)
1596
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1605
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Griessinger E, Anjos-Afonso F, Pizzitola I, Rouault-Pierre K, Vargaftig J, Taussig D, Gribben J, Lassailly F et al.
(
2014
)
.
A Niche‐Like Culture System Allowing the Maintenance of Primary Human Acute Myeloid Leukemia‐Initiating Cells: A New Tool to Decipher Their Chemoresistance and Self‐Renewal Mechanisms
.
Stem Cells Translational Medicine
vol.
3
,
(
4
)
520
-
529
.
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Biondi A, Biagi E, Bonnet D
(
2014
)
.
Chimeric Antigen Receptor for Specific Targeting of Acute Myeloid Leukaemia
.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
.
vol.
36
,
324
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325
.
Das A, Furness C, White A, Hayday T, Rouault-Pierre K, Greaves M, Hayday AC, Gibbons DL
(
2014
)
.
T-cell production of interleukin-8 (CXCL8) is enriched in recent thymic emigrants
.
IMMUNOLOGY
.
vol.
143
,
46
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47
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Mian SA, Rouault-Pierre K, Smith AE, Seidl T, Kulasekararaj AG, Mohamedali AM, Shinde S, Bonnet D et al.
(
2013
)
.
SF3B1 Mutant Clones From Patients With Refractory Anaemia With Ringed Sideroblasts (RARS) Originate From The Early Haematopoietic Stem Cells and Maintain Their Engraftment Potential
.
Blood
.
vol.
122
,
Rouault-Pierre K, Lopez-Onieva L, Foster K, Anjos-Afonso F, Lamrissi-Garcia I, Serrano-Sanchez M, Mitter R, Ivanovic Z et al.
(
2013
)
.
HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress
.
Cell Stem Cell
vol.
13
,
(
5
)
549
-
563
.
Rouault-Pierre K, Lopez-Onieva L, Foster K, Anjos-Afonso F, Lamrissi-Garcia I, Serrano-Sanchez M, Mitter R, Ivanovic Z et al.
(
2013
)
.
HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress
.
Cell Stem Cell
vol.
13
,
(
5
)
549
-
563
.
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Biondi A, Biagi E, Bonnet D
(
2013
)
.
Chimeric antigen receptor for specific targeting of acute myeloid leukemia
.
Cytotherapy
.
vol.
15
,
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Biondi A, Biagi E, Bonnet D
(
2013
)
.
CHIMERIC ANTIGEN RECEPTOR FOR SPECIFIC TARGETING OF ACUTE MYELOID LEUKAEMIA
.
PEDIATRIC BLOOD & CANCER
.
vol.
60
,
29
-
29
.
Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Biondi A, Biagi E, Bonnet D
(
2012
)
.
Chimeric Antigen Receptor for Specific Targeting of Acute Myeloid Leukemia
.
Blood
.
vol.
120
,
Rouault-Pierre K, Lopez-Onieva L, Rezvani H, Anjos-Afonso F, Lamrissi-Garcia I, Vlaski M, De Verneuil H, Ivanovic Z et al.
(
2012
)
.
HYPOXIA-INDUCIBLE FACTOR 1A IS IMPORTANT TO MAINTAIN HUMAN HSC, BUT HIF-2A IS ESSENTIAL TO PROTECT THEM FROM ROS INDUCED APOPTOSIS
.
EXPERIMENTAL HEMATOLOGY
.
vol.
40
,
S102
-
S103
.