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Publications:  Dr Thomas Iskratsch

Ward M, Iskratsch T(2020). Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart. Biochimica et Biophysica Acta - Molecular Cell Research vol. 1867, (3)
10.1016/j.bbamcr.2019.01.017
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55484
Di Cio S, Iskratsch T, Connelly JT, Gautrot JE(2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Biomaterials vol. 232,
10.1016/j.biomaterials.2019.119683
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64098
Xanthis I, Iskratsch T(2019). Lamin-A Mechano-Protects the Heart. Developmental Cell
10.1016/j.devcel.2019.05.041
Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al.(2019). Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation. Cancer Research
10.1158/0008-5472.CAN-18-3934
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58082
Sit B, Gutmann D, Iskratsch T(2019). Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing. Journal of Muscle Research and Cell Motility vol. 40, (2) 197-209.
10.1007/s10974-019-09529-7
Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T et al.(2019). Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control. Faraday Discussions
10.1039/c9fd00023b
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56570
Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T, Lappalainen P(2018). Calponin-3 is critical for coordinated contractility of actin stress fibers. Scientific Reports
10.1038/s41598-018-35948-6
https://qmro.qmul.ac.uk/xmlui/handle/123456789/53548
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L et al.(2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44, (3) 326-336.e3.
10.1016/j.devcel.2017.12.024
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31952
Koldyka O, Pandey P, Iskratsch T, Ehler E (2018). Similar Effects of Humoral or Mechanical Stress on Cell-Cell Contacts in Cultured Cardiomyocytes. BIOPHYSICAL JOURNAL. vol. 114, 496A-496A.
10.1016/j.bpj.2017.11.2719
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49357
Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN, Lu HH(2017). Polymer fiber-based models of connective tissue repair and healing. Biomaterials vol. 112, 303-312.
10.1016/j.biomaterials.2016.10.013
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31947
Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML et al.(2016). Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol vol. 94, (10) 981-993.
10.1038/icb.2016.61
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29743
Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N et al.(2016). α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions. Mol Biol Cell vol. 27, (22) 3471-3479.
10.1091/mbc.E16-02-0107
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29744
Pluess M, Iskratsch T, Bennett P, Dwyer J, Pandey P, dos Remedios C, Ehler E (2016). Cellular Stress Affects the Nucleoskeleton in Dilated Cardiomyopathy. BIOPHYSICAL JOURNAL. vol. 110, 366A-367A.
10.1016/j.bpj.2015.11.1976
Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B et al.(2015). Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices. Nat Cell Biol vol. 18, (1) 33-42.
10.1038/ncb3277
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29745
Ehler E, Pluess M, Randall T, Dwyer J, Iskratsch T, Dos Remedios C, Bennett P (2015). Changes in cardiac cytoarchitecture in human dilated cardiomyopathy. EUROPEAN HEART JOURNAL. vol. 36, 834-834.
Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T(2015). Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb) vol. 7, (10) 1272-1284.
10.1039/c5ib00032g
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29127
Wolfenson H, Iskratsch T, Sheetz MP(2014). Early events in cell spreading as a model for quantitative analysis of biomechanical events. Biophysical Journal vol. 107, (11) 2508-2514.
10.1016/j.bpj.2014.10.041
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29264
Iskratsch T, Wolfenson H, Sheetz MP(2014). Appreciating force and shape—the rise of mechanotransduction in cell biology. Nature reviews. Molecular cell biology vol. 15, (12) 825-833.
10.1038/nrm3903
Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B et al. (2014). Rigidity sensing by tropomyosin-regulated nanometer steps in local contractions. MOLECULAR BIOLOGY OF THE CELL. vol. 25,
Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG, Ehler E(2014). The formin FHOD1 in cardiomyocytes. Anat Rec (Hoboken) vol. 297, (9) 1560-1570.
10.1002/ar.22984
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29747
Iskratsch T, Yu C-H, Mathur A, Liu S, Stevenin V, Dwyer J, Hone J, Ehler E et al. (2014). FHOD1 at Early Integrin Adhesions Drives Cell Spreading. BIOPHYSICAL JOURNAL. vol. 106, 163A-163A.
10.1016/j.bpj.2013.11.929
Zhang X, Moore SW, Iskratsch T, Sheetz MP(2014). N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading. Journal of Cell Science vol. 127, (7) 1394-1405.
10.1242/jcs.134692
https://qmro.qmul.ac.uk/xmlui/handle/123456789/29126
Iskratsch T, Yu CH, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E et al.(2013). FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration. Developmental Cell vol. 27, (5) 545-559.
10.1016/j.devcel.2013.11.003
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30003
Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E(2013). Two distinct phosphorylation events govern the function of muscle FHOD3. Cellular and Molecular Life Sciences vol. 70, (5) 893-908.
10.1007/s00018-012-1154-7
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30023
Meacci G, Stachowiak M, Liu S, Iskratsch T, Mathur A, Wolfenson H, Ghassemi S, Roca-Cusachs P et al. (2013). Sarcomere-Like Units Contract Cell Edges. BIOPHYSICAL JOURNAL. vol. 104, 477A-478A.
10.1016/j.bpj.2012.11.2639
Lynch CD, Lazar AM, Iskratsch T, Zhang X, Sheetz MP(2013). Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions. Molecular Biology of the Cell vol. 24, (1) 21-30.
10.1091/mbc.E12-05-0377
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30043
Dwyer J, Iskratsch T, Ehler E(2012). Actin in striated muscle: Recent insights into assembly and maintenance. Biophysical Reviews vol. 4, (1) 17-25.
10.1007/s12551-011-0062-7
Roca-Cusachs P, Iskratsch T, Sheetz MP(2012). Finding the weakest link-exploring integrin-mediated mechanical molecular pathways. Journal of Cell Science vol. 125, (13) 3025-3038.
10.1242/jcs.095794
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30044
Iskratsch T, Yu C-H, Mathur A, Hone J, Sheetz M (2012). Early cell spreading depends on actin polymerisation from integrin clusters by FHOD1. MOLECULAR BIOLOGY OF THE CELL. vol. 23,
Meacci G, Stachowiak M, Liu S, Iskratsch T, Mathur A, Wolfenson H, Ghassemi S, Roca-Cusachs P et al. (2012). Sarcomere-Like Units Contract Cell Edges. MOLECULAR BIOLOGY OF THE CELL. vol. 23,
Iskratsch T, Ehler E(2011). Formin-g muscle cytoarchitecture. BioArchitecture vol. 1, (2) 66-68.
10.4161/bioa.1.2.15467
Iskratsch T, Sheetz M (2011). Sequential action of formin family proteins during fibroblast adhesion and spreading. MOLECULAR BIOLOGY OF THE CELL. vol. 22,
Iskratsch T, Lange S, Dwyer J, Kho AL, Dos Remedios C, Ehler E(2010). Formin follows function: A muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. Journal of Cell Biology vol. 191, (6) 1159-1172.
10.1083/jcb.201005060
https://qmro.qmul.ac.uk/xmlui/handle/123456789/30063
Herbst R, Iskratsch T, Unger E, Bittner RE(2009). Aberrant development of neuromuscular junctions in glycosylation-defective Large<sup>myd</sup> mice. Neuromuscular Disorders vol. 19, (5) 366-378.
10.1016/j.nmd.2009.02.011
Gutternigg M, Rendi¿ D, Voglauer R, Iskratsch T, Wilson IBH(2009). Mammalian cells contain a second nucleocytoplasmic Hexosaminidase. Biochemical Journal vol. 419, (1) 83-90.
10.1042/BJ20081630
Iskratsch T, Braun A, Paschinger K, Wilson IBH(2009). Specificity analysis of lectins and antibodies using remodeled glycoproteins. Analytical Biochemistry vol. 386, (2) 133-146.
10.1016/j.ab.2008.12.005
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