Publications:  Dr Thomas Iskratsch

Ward M, Iskratsch T(2020). Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart. Biochimica et Biophysica Acta - Molecular Cell Research vol. 1867, (3)

Di Cio S, Iskratsch T, Connelly JT, Gautrot JE(2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Biomaterials vol. 232,

Xanthis I, Iskratsch T(2019). Lamin-A Mechano-Protects the Heart. Developmental Cell

Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al.(2019). Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation. Cancer Research

Sit B, Gutmann D, Iskratsch T(2019). Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing. Journal of Muscle Research and Cell Motility vol. 40, (2) 197-209.

Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T et al.(2019). Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control. Faraday Discussions

Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T, Lappalainen P(2018). Calponin-3 is critical for coordinated contractility of actin stress fibers. Scientific Reports

Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L et al.(2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44, (3) 326-336.e3.

Koldyka O, Pandey P, Iskratsch T, Ehler E (2018). Similar Effects of Humoral or Mechanical Stress on Cell-Cell Contacts in Cultured Cardiomyocytes. BIOPHYSICAL JOURNAL. vol. 114, 496A-496A.

Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN, Lu HH(2017). Polymer fiber-based models of connective tissue repair and healing. Biomaterials vol. 112, 303-312.

Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML et al.(2016). Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol vol. 94, (10) 981-993.

Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N et al.(2016). α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions. Mol Biol Cell vol. 27, (22) 3471-3479.

Pluess M, Iskratsch T, Bennett P, Dwyer J, Pandey P, dos Remedios C, Ehler E (2016). Cellular Stress Affects the Nucleoskeleton in Dilated Cardiomyopathy. BIOPHYSICAL JOURNAL. vol. 110, 366A-367A.

Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B et al.(2015). Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices. Nat Cell Biol vol. 18, (1) 33-42.

Ehler E, Pluess M, Randall T, Dwyer J, Iskratsch T, Dos Remedios C, Bennett P (2015). Changes in cardiac cytoarchitecture in human dilated cardiomyopathy. EUROPEAN HEART JOURNAL. vol. 36, 834-834.

Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T(2015). Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb) vol. 7, (10) 1272-1284.

Wolfenson H, Iskratsch T, Sheetz MP(2014). Early events in cell spreading as a model for quantitative analysis of biomechanical events. Biophysical Journal vol. 107, (11) 2508-2514.

Iskratsch T, Wolfenson H, Sheetz MP(2014). Appreciating force and shape—the rise of mechanotransduction in cell biology. Nature reviews. Molecular cell biology vol. 15, (12) 825-833.

Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B et al. (2014). Rigidity sensing by tropomyosin-regulated nanometer steps in local contractions. MOLECULAR BIOLOGY OF THE CELL. vol. 25,

Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG, Ehler E(2014). The formin FHOD1 in cardiomyocytes. Anat Rec (Hoboken) vol. 297, (9) 1560-1570.

Iskratsch T, Yu C-H, Mathur A, Liu S, Stevenin V, Dwyer J, Hone J, Ehler E et al. (2014). FHOD1 at Early Integrin Adhesions Drives Cell Spreading. BIOPHYSICAL JOURNAL. vol. 106, 163A-163A.

Zhang X, Moore SW, Iskratsch T, Sheetz MP(2014). N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading. Journal of Cell Science vol. 127, (7) 1394-1405.

Iskratsch T, Yu CH, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E et al.(2013). FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration. Developmental Cell vol. 27, (5) 545-559.

Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E(2013). Two distinct phosphorylation events govern the function of muscle FHOD3. Cellular and Molecular Life Sciences vol. 70, (5) 893-908.

Meacci G, Stachowiak M, Liu S, Iskratsch T, Mathur A, Wolfenson H, Ghassemi S, Roca-Cusachs P et al. (2013). Sarcomere-Like Units Contract Cell Edges. BIOPHYSICAL JOURNAL. vol. 104, 477A-478A.

Lynch CD, Lazar AM, Iskratsch T, Zhang X, Sheetz MP(2013). Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions. Molecular Biology of the Cell vol. 24, (1) 21-30.

Dwyer J, Iskratsch T, Ehler E(2012). Actin in striated muscle: Recent insights into assembly and maintenance. Biophysical Reviews vol. 4, (1) 17-25.

Roca-Cusachs P, Iskratsch T, Sheetz MP(2012). Finding the weakest link-exploring integrin-mediated mechanical molecular pathways. Journal of Cell Science vol. 125, (13) 3025-3038.

Iskratsch T, Yu C-H, Mathur A, Hone J, Sheetz M (2012). Early cell spreading depends on actin polymerisation from integrin clusters by FHOD1. MOLECULAR BIOLOGY OF THE CELL. vol. 23,

Meacci G, Stachowiak M, Liu S, Iskratsch T, Mathur A, Wolfenson H, Ghassemi S, Roca-Cusachs P et al. (2012). Sarcomere-Like Units Contract Cell Edges. MOLECULAR BIOLOGY OF THE CELL. vol. 23,

Iskratsch T, Ehler E(2011). Formin-g muscle cytoarchitecture. BioArchitecture vol. 1, (2) 66-68.

Iskratsch T, Sheetz M (2011). Sequential action of formin family proteins during fibroblast adhesion and spreading. MOLECULAR BIOLOGY OF THE CELL. vol. 22,

Iskratsch T, Lange S, Dwyer J, Kho AL, Dos Remedios C, Ehler E(2010). Formin follows function: A muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. Journal of Cell Biology vol. 191, (6) 1159-1172.

Herbst R, Iskratsch T, Unger E, Bittner RE(2009). Aberrant development of neuromuscular junctions in glycosylation-defective Large^myd mice. Neuromuscular Disorders vol. 19, (5) 366-378.

Gutternigg M, Rendi¿ D, Voglauer R, Iskratsch T, Wilson IBH(2009). Mammalian cells contain a second nucleocytoplasmic Hexosaminidase. Biochemical Journal vol. 419, (1) 83-90.

Iskratsch T, Braun A, Paschinger K, Wilson IBH(2009). Specificity analysis of lectins and antibodies using remodeled glycoproteins. Analytical Biochemistry vol. 386, (2) 133-146.