Publications: Prof Rob Krams

Bourantas C, Torii R, Karabasov S, Krams R ( 2024 ) . Editorial: Computational modelling of cardiovascular hemodynamics and machine learning . Frontiers in Cardiovascular Medicine vol. 11 ,

Savvopoulos F, Keeling MC, Carassiti D, Fogell NA, Patel MB, Naser J, Gavara N, de Silva R et al. ( 2024 ) . Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy . Journal of The Royal Society Interface vol. 21 , ( 211 )

Popovs S, Munkevics M, Krama T, Krams R, Sledevskis E, Trakimas G, Zants K, Grigorjeva T et al. ( 2024 ) . Explaining the survival of the sickest: altered walking patterns are linked with improved adult survival in Drosophila melanogaster grown with predators during larval development . Behaviour vol. 161 , ( 2 ) 133 - 148 .

Bajaj R, Huang X, Alves-Kotzev N, Weyers J, Levine M, Garg M, Maung S, Bransby K et al. ( 2023 ) . TCT-613 Comparison of Histology-Trained Deep Learning Approach With Human Expert Analysts for Automated Plaque Component Classification in Hybrid Intravascular Ultrasound-Optical Coherence Tomography Images . Journal of the American College of Cardiology vol. 82 , ( 17 ) b246 - b247 .

Morgan B, Murali AR, Preston G, Sima YA, Chamorro LM, Bourantas C, Torii R, Mathur A et al. ( 2023 ) . A physics-based machine learning technique rapidly reconstructs the wall-shear stress and pressure fields in coronary arteries . Frontiers in Cardiovascular Medicine

Fogell NAT, Patel M, Yang P, Ruis RM, Garcia DB, Naser J, Savvopoulos F, Davies Taylor C et al. ( 2023 ) . Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation . Annals of Biomedical Engineering vol. 51 , ( 9 ) 1950 - 1964 .

Krams R, Preston G, Chamorro L, Morgan B, Sima Y, Murali A, Bourantas C, Torii R et al. ( 2023 ) . BS12 A novel physics-based artificial intelligence technique rapidly reconstructs the 3D velocity, shear stress and pressure fields in coronary arteries . Conference: Basic Sciencea255.1 - a2a255 .

Krams R, Towhidi L ( 2023 ) . BS13 Ultra-highly flexible, accurate, high throughput platform for personalised drug screening studies . Conference: Basic Sciencea255.2 - a2a255 .

Krams R, Chamorro L, Komo Z, Bashir A, Torii R, Bourantas C, Zhang Q, Mathur A et al. ( 2023 ) . BS14 A fully automated vulnerable plaque classifier for oct using co-registered histological images and transfer learning learning . Conference: Basic Sciencea255.3 - a2a256 .

Krams R, Herault S, Jaitly A, Bala R, Calistus A, Towhidi L ( 2023 ) . BS15 Ultra-highly flexible, accurate, high throughput platform for knock-in studies . Conference: Basic Sciencea256.1 - a2a256 .

Çap M, Torii R, Onuma Y, Krams R, Bennett MR, Stone PH, Serruys PW, Bourantas CV ( 2023 ) . Editorial: Computational modeling for assessing coronary artery pathophysiology . Frontiers in Cardiovascular Medicine vol. 10 ,

Krama T, Munkevics M, Krams R, Grigorjeva T, Trakimas G, Jõers P, Popovs S, Zants K et al. ( 2023 ) . Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster . Frontiers in Behavioral Neuroscience vol. 17 ,

Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al. ( 2022 ) . JAG1-NOTCH4 mechanosensing drives atherosclerosis . Science Advances vol. 8 , ( 35 )

Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K et al. ( 2022 ) . TCT-254 Histology-Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images . Journal of the American College of Cardiology vol. 80 , ( 12 )

Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K et al. ( 2022 ) . Histology- Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 80 , B100 - B100 .

Herault S, Naser J, Carassiti D, Chooi KY, Nikolopoulou R, Font ML, Patel M, Pedrigi R et al. ( 2021 ) . Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells . Biophysical Reviews vol. 13 , ( 5 ) 787 - 796 .

Naser J, Fogell N, Patel M, Yang P, Krams R, Wentzel JJ, Aben JP, De Silva R ( 2021 ) . Moving shear stress towards the clinic: preclinical comparison of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations . European Heart Journal vol. 42 , ( Supplement_1 )

( 2021 ) . Correction: BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model . Heart vol. 107 , ( 19 ) e10 - e10 .

Patel M, Savvopoulos F, Berggren CC, Aslanidou L, Timmins LH, de Silva R, Pedrigi RM, Krams R ( 2021 ) . Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis . Journal of Biomechanics vol. 128 ,

Naser J, Mein CA, Wozniak E, Carassiti D, Mahomed AS, Krams R, de Silva R ( 2021 ) . BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model . Heart . Conference: Heart vol. 107 , a166 - a167 .

Post AL, Cernohorsky P, Pedrigi RM, Streekstra GJ, d’Hooghe JNS, Annema JT, Strackee SD, Krams R et al. ( 2020 ) . 3D co-registration algorithm for catheter-based optical coherence tomography . Optics Continuum vol. 3 , ( 10 )

Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R et al. ( 2020 ) . Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque . Nanotheranostics vol. 4 , ( 4 ) 184 - 194 .

Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU et al. ( 2020 ) . Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events . JACC Cardiovascular Imaging vol. 13 , ( 10 ) 2206 - 2219 .

Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J et al. ( 2019 ) . Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications . European Heart Journal

Baumbach A ( 2019 ) . Reliable in Vivo Intravascular Imaging Plaque Characterisation: A Challenge Unmet . American Heart Journal

Mohri Z, Del Rio Hernandez A, Krams R ( 2019 ) . The emerging role of YAP/TAZ in mechanotransduction . J Thorac Dis vol. 9 , ( 5 ) E507 - E509 .

Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR et al. ( 2019 ) . Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo . Sci Rep vol. 9 , ( 1 ) 4738 - 4738 .

Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E et al. ( 2019 ) . Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis . EuroIntervention vol. 14 , ( 10 ) 1129 - 1135 .

Evans RJ, Hernández-Gil J, Mohri Z, Chooi KY, Lavin-Plaza B, Phinikaridou A, Pease JE, Krams R et al. ( 2018 ) . P11 DEVELOPING NEW TARGETED MOLECULAR CONTRAST AGENTS FOR IMAGING INFLAMMATION OF VULNERABLE PLAQUES . Cardiovascular Research . vol. 114 , s3 - s4 .

Yang P, Silva R, Pedrigi R, Patel M, Chooi Y, Ahmed R, Naser J, Krams R ( 2018 ) . P34 FLUID-STRUCTURE INTERACTION MODELLING FOR ANALYSING ADVANCED CORONARY ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC HYPERLIPIDAEMIC MINIPIGS . Cardiovascular Research . vol. 114 , s10 - s10 .

Maimari N, Pedrigi RM, Russo A, Broda K, Krams R ( 2018 ) . Integration of flow studies for robust selection of mechanoresponsive genes . Thrombosis and Haemostasis vol. 115 , ( 03 ) 474 - 483 .

Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C, Krams R ( 2018 ) . New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress . Current Opinion in Biomedical Engineering vol. 5 , 96 - 104 .

Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW et al. ( 2017 ) . Stabilisation of atherosclerotic plaques . Thrombosis and Haemostasis vol. 106 , ( 01 ) 1 - 19 .

Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T et al. ( 2017 ) . Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis . Circulation vol. 136 , ( 12 ) 1140 - 1154 .

Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M et al. ( 2017 ) . Connexin40 controls endothelial activation by dampening NFκB activation . Oncotarget vol. 8 , ( 31 ) 50972 - 50986 .

Poulsen CB, Pedrigi R, Holm N, Pareek N, Kilic I, Post AL, Di Mario C, Bentzon J et al. ( 2017 ) . COMPARISON OF IN VIVO OPTICAL COHERENCE TOMOGRAPHY DERIVED PLAQUE PHENOTYPE AND BURDEN WITH HISTOLOGY IN A PORCINE MODEL OF ADVANCED CORONARY ATHEROSCLEROSIS . Journal of the American College of Cardiology . vol. 69 ,

Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M et al. ( 2016 ) . Zebrafish Model for Functional Screening of Flow-Responsive Genes . Arterioscler Thromb Vasc Biol vol. 37 , ( 1 ) 130 - 143 .

Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM et al. ( 2016 ) . Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB . Ann Biomed Eng vol. 45 , ( 4 ) 898 - 909 .

Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L et al. ( 2016 ) . Influence of shear stress magnitude and direction on atherosclerotic plaque composition . Royal Society Open Science vol. 3 , ( 10 )

Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L et al. ( 2016 ) . Development of a synthetic gene network to modulate gene expression by mechanical forces . Sci Rep vol. 6 , 29643 - 29643 .

Wilson RA, Di Mario C, Krams R, Loe Kie Soei, Wenguang L, Laird AC, The SHK, Gussenhoven E et al. ( 2016 ) . In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia . Angiology vol. 46 , ( 6 ) 481 - 488 .

Denis J-F, Scheckenbach L, Pfenniger A, Meens M, Krams R, Miquerol L, Taffet S, Chanson M et al. ( 2016 ) . 0109 : Connexin40 controls endothelial activation by dampening NF B activation . Archives of Cardiovascular Diseases Supplements vol. 8 , ( 3 ) 203 - 203 .

Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW et al. ( 2016 ) . Comparison between direct and reverse electroporation of cells in situ: a simulation study . Physiological Reports vol. 4 , ( 6 )

Antonacci G, Pedrigi R, Krams R, Török P . Quantification of plaque stiffness by Brillouin microscopy (Conference Presentation) . Proceedings of SPIE . Conference: Optical Elastography and Tissue Biomechanics III

Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R et al. ( 2016 ) . Corrigendum to “Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques” [J Mol Cell Cardiol] 89B (2015) 168–172 . Journal of Molecular and Cellular Cardiology vol. 91 ,

Krams RM, Pedrigi RM, Kis Z ( 2016 ) . A novel assay for regulating transcription factors by flow . CARDIOVASCULAR RESEARCH . vol. 111 , S117 - S117 .

Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, de Silva R, Paterson C, Krams R, Török P ( 2015 ) . Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma . Journal of The Royal Society Interface vol. 12 , ( 112 )

Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R et al. ( 2015 ) . Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques . Journal of Molecular and Cellular Cardiology vol. 89 , ( Pt B ) 168 - 172 .

Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV et al. ( 2015 ) . Shear stress-induced atherosclerotic plaque composition in ApoE−/− mice is modulated by connexin37 . Atherosclerosis vol. 243 , ( 1 ) 1 - 10 .

Pedrigi RM, Poulsen CB, Mehta VV, Ramsing Holm N, Pareek N, Post AL, Kilic ID, Banya WAS et al. ( 2015 ) . Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs . Circulation vol. 132 , ( 11 ) 1003 - 1012 .

Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R, Choi JJ ( 2015 ) . Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow . Ultrasound in Medicine & Biology vol. 41 , ( 9 ) 2435 - 2448 .

da Conceicao Pereira G, Krams R ( 2015 ) . 182 Flow Characteristics Enhanced by the Compliant Arteries and their effects in Vulnerable Plaque Formation . Heart . vol. 101 ,

Kis Z, Pereira HS, Homma T, Pedrigi RM, Krams R ( 2015 ) . Mammalian synthetic biology: emerging medical applications . Journal of The Royal Society Interface vol. 12 , ( 106 )

Poulsen CB, Pedrigi RM, Mehta VV, Post A, Pareek N, Holm NR, Kilic D, El-Bahnasawi M et al. ( 2015 ) . INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA . Journal of the American College of Cardiology . vol. 65 ,

Villanueva ME, Pereira HSA, Rajyaguru J, Krams R, Chachuat B ( 2015 ) . Bifurcation and stability analysis of nonlinear dynamic systems using complete search . Computing and Systems Technology Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting . vol. 2 , 627 - 628 .

Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA et al. ( 2015 ) . Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors . Physical Chemistry Chemical Physics vol. 17 , ( 28 ) 18393 - 18402 .

Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ, Weinberg PD ( 2014 ) . Elevated Uptake of Plasma Macromolecules by Regions of Arterial Wall Predisposed to Plaque Instability in a Mouse Model . PLOS ONE vol. 9 , ( 12 )

Towhidi L, Maimari N, Kis Z, Khodadadi D, Krams R ( 2014 ) . A novel high-throughput platform for siRNA transfection of primary mammalian cells . Atherosclerosis vol. 237 , ( 2 )

Maimari N, Towhidi L, Oh D, Broda K, Russo A, Krams R ( 2014 ) . A novel integrated platform for gene network inference and validation: beyond the dream consortium . Atherosclerosis vol. 237 , ( 2 )

Pereira G, Krams R ( 2014 ) . Forecasting vulnerable plaque response to aemorheological flow . Atherosclerosis vol. 237 , ( 2 )

Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W, Krams R ( 2014 ) . Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis . Atherosclerosis vol. 237 , ( 2 )

Maimari N, Broda K, Kakas A, Russo A, Krams R ( 2014 ) . Symbolic representation and inference of regulatory networks: uncovering mechanosensitive gene networks . Atherosclerosis vol. 237 , ( 2 )

Homma T, Caurette P, Silva HJ, Yamada I, Makrydaki E, Bovens S, Pedrigi R, Petretto EG et al. ( 2014 ) . Transcriptome analysis of local shear dependent gene expression in endothelial cells during thin-cap fibroatheroma(TCFA) development . Atherosclerosis . vol. 237 ,

Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P et al. ( 2014 ) . Biomechanical factors in atherosclerosis: mechanisms and clinical implications . European Heart Journal vol. 35 , ( 43 ) 3013 - 3020 .

Maimari N, Broda K, Kakas A, Krams R, Russo A ( 2014 ) . Symbolic Representation and Inference of Regulatory Network Structures . Logical Modeling of Biological Systems , Wiley

Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al. ( 2014 ) . In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106 . Molecular Imaging vol. 13 , ( 6 )

Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al. ( 2014 ) . In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106 . Mol Imaging vol. 13 , ( 6 )

Pedrigi RM, de Silva R, Bovens SM, Mehta VV, Petretto E, Krams R ( 2014 ) . Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress . Arteriosclerosis Thrombosis and Vascular Biology vol. 34 , ( 10 ) 2224 - 2231 .

Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P et al. ( 2014 ) . Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow . Journal of The Royal Society Interface vol. 11 , ( 92 )

Mohri Z, Rowland E, Clarke LA, De Luca A, Krams R, Weinberg PD ( 2014 ) . Elevated arterial wall permeability may cause vulnerable plaque formation in mice . Atherosclerosis . vol. 232 ,

Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A, Krams R ( 2014 ) . An In situ electroporation and flow device for mechanotransduction studies . Microarrays: Principles, Applications and Technologies ,

Pereira G, Krams R, van Wachem B ( 2014 ) . Modelling the Mechanics of the Circulation: Blood Rheology and Atherosclerosis . Biophysical Journal . vol. 106 ,

Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Coppola G et al. ( 2013 ) . Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow† . Journal of The Royal Society Interface vol. 10 , ( 89 )

Maimari N, Turliuc CR, Broda K, Kakas A, Krams R, Russo A ( 2013 ) . ARNI: Abductive inference of complex regulatory network structures . Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) . vol. 8130 LNBI , 235 - 237 .

Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R, Monaco C ( 2013 ) . M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques . European Heart Journal vol. 34 , ( suppl_1 ) p2398 - p2398 .

Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al. ( 2013 ) . Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells . European Heart Journal vol. 34 , ( suppl_1 ) p582 - p582 .

Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S et al. ( 2013 ) . Stabilization of atherosclerotic plaques: an update . European Heart Journal vol. 34 , ( 42 ) 3251 - 3258 .

Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V et al. ( 2013 ) . Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The “Stenotic Stent” . Journal of Cardiovascular Translational Research vol. 6 , ( 4 ) 640 - 648 .

Seneviratne A, Cole J, Goddard M, Udalova I, Krams R, Monaco C ( 2013 ) . 181 M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE . Heart . vol. 99 ,

Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L, Krams R ( 2013 ) . Systems biology of the functional and dysfunctional endothelium . Cardiovascular Research vol. 99 , ( 2 ) 334 - 341 .

Wentzel J, Gijsen F, Krams R, de Crom R, Cheng C, Groen H, van der Giessen A, van der Steen A ( 2013 ) . Shear stress and the vulnerable plaque . The Vulnerable Plaque, Second Edition , Taylor & Francis

Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB, Rainger GE ( 2013 ) . The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment . Arteriosclerosis Thrombosis and Vascular Biology vol. 33 , ( 4 ) 694 - 701 .

Olivon VC, Fraga-Silva RA, Segers D, Demougeot C, de Oliveira AM, Savergnini SS, Berthelot A, de Crom R et al. ( 2013 ) . Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice . Atherosclerosis vol. 227 , ( 2 ) 236 - 243 .

Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R, Monaco C ( 2013 ) . M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques . EUROPEAN HEART JOURNAL . vol. 34 , 443 - 443 .

Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al. ( 2013 ) . Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells . EUROPEAN HEART JOURNAL . vol. 34 , 110 - 110 .

Falck-Hansen MA, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R, Monaco C ( 2012 ) . Macrophage activation during chronic inflammation in atherosclerosis . Atherosclerosis . vol. 225 ,

Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Krams R, Monaco C ( 2012 ) . Macrophage polarisation in shear stress modulated atherosclerotic plaque vulnerability . Atherosclerosis . vol. 225 ,

Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J et al. ( 2012 ) . Fibromodulin Deficiency Reduces Low-Density Lipoprotein Accumulation in Atherosclerotic Plaques in Apolipoprotein E–Null Mice . Arteriosclerosis Thrombosis and Vascular Biology vol. 33 , ( 2 ) 354 - 361 .

Foin N, Sen S, Petraco R, Torii R, Nijjer S, Xu YX, Mehta V, Mayet J et al. ( 2012 ) . TCT-231 Investigation of Fractional Flow Reserve Correlation with Direct Anatomical Parameters Using a Percutaneous Model of Coronary Artery Stenosis . Journal of the American College of Cardiology . vol. 60 ,

Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC et al. ( 2012 ) . Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells . Journal of Molecular and Cellular Cardiology vol. 53 , ( 2 ) 299 - 309 .

Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E et al. ( 2012 ) . Systems and synthetic biology of the vessel wall . FEBS Letters vol. 586 , ( 15 ) 2164 - 2170 .

van Bochove GS, Sanders HMHF, de Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ, Nicolay K ( 2012 ) . Molecular MR Imaging of Collagen in Mouse Atherosclerosis by Using Paramagnetic CNA35 Micelles . European Journal of Inorganic Chemistry vol. 2012 , ( 12 ) 2115 - 2125 .

Schlueter J, Brand T, Henderson DJ, Boczonadi V, Humbert P, Chaudhry B, Sedmera D, Svatunkova J et al. ( 2012 ) . Poster session 1 . Cardiovascular Research vol. 93 , ( suppl_1 ) s9 - s45 .

Nanka O, Krejci E, Pesevski Z, Sedmera D, Smart N, Rossdeutsch A, Dube KN, Riegler J et al. ( 2012 ) . Poster session 3 . Cardiovascular Research vol. 93 , ( suppl_1 ) s92 - s127 .

Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S et al. ( 2012 ) . Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice . Journal of Visualized Experiments ( 59 )

Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S et al. ( 2012 ) . Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice . Journal of Visualized Experiments ( 59 )

Caro CG, Seneviratne A, Monaco C, Hou D, Singh J, Gilson P, Burke MG, Heraty KB et al. ( 2012 ) . Arterial stent-associated intimal hyperplasia and wall hypoxia . CARDIOVASCULAR RESEARCH . vol. 93 , S116 - S116 .

Falck-Hansen M, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R, Monaco C ( 2012 ) . Expression of the regulatory receptor CD200R on macrophages is regulated by polarization signals in atherosclerosis . CARDIOVASCULAR RESEARCH . vol. 93 , S19 - S19 .

Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Chan PH, Davies JE, Xu XY et al. ( 2012 ) . Kissing Balloon or Sequential Dilation of the Side Branch and Main Vessel for Provisional Stenting of Bifurcations Lessons From Micro-Computed Tomography and Computational Simulations . JACC Cardiovascular Interventions vol. 5 , ( 1 ) 47 - 56 .

Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Cross AJ, Krams R, Monaco C ( 2012 ) . Macrophage heterogeneity in shear stress modulated atherosclerotic plaque development . CARDIOVASCULAR RESEARCH . vol. 93 , S51 - S51 .

Segers D, Lipton JA, Leenen PJM, Cheng C, Tempel D, Pasterkamp G, Moll FL, de Crom R et al. ( 2011 ) . Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans . International Journal of Inflammation vol. 2011 ,

Foin N, Secco GG, Ghilencea L, Krams R, Di Mario C ( 2011 ) . Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting . EuroIntervention vol. 7 , ( 5 ) 597 - 604 .

Foin N, Viceconte N, Chan PH, Lindsay AC, Krams R, Di Mario C ( 2011 ) . Jailed side branches . Journal of Cardiovascular Medicine vol. 12 , ( 8 ) 581 - 582 .

De Crom R, Leenen P, Nicolay K, Krams R ( 2011 ) . Shear stress is a major determinant for getting a heart attack . Hart Bulletin vol. 42 , ( 3 ) 67 - 70 .

Foin N, Secco G, Ghilencea L, Krams R, Di Mario C ( 2011 ) . FINAL PROXIMAL POST-DILATATION IS NECESSARY AFTER KISSING BALLOON IN BIFURCATIONS STENTING . Journal of the American College of Cardiology . vol. 57 ,

Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA et al. ( 2011 ) . Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1 . Circulation Research vol. 108 , ( 8 ) 950 - 959 .

Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT et al. ( 2011 ) . Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1 . Circulation vol. 123 , ( 5 ) 524 - 532 .

Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H et al. ( 2011 ) . <SUP>18</SUP>FEDAA is a more specific probe than <SUP>18</SUP>FDG for imaging vascular inflammation . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38 , S210 - S210 .

Foin N, Secco G, Sen S, Davies JE, Krams R, Di Mario C ( 2011 ) . Bench Micro-CT study and OCT Experience of a Final Proximal Post-dilatation to Optimize Results in Bifurcation Stenting . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 58 , B87 - B87 .

Olivon VC, Segers D, de Oliveira AM, Demougeot C, Bertholet A, de Crom R, Krams R, Stergiopulos N et al. ( 2011 ) . Effects of arginase inhibition on shear stress-induced plaque size and composition . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 41 , 6 - 6 .

Pfenniger A, Sutter E, Cuhlmann S, Evans PC, Krams R, Kwak BR ( 2011 ) . Endothelial Cx37 expression is regulated by the shear stress responsive transcription factor KLF2 . EUROPEAN HEART JOURNAL . vol. 32 , 937 - 937 .

Falck-Hansen M, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R, Monaco C ( 2011 ) . Expression of the regulatory receptor CD200R on macrophages is regulated by polarization signals in atherosclerosis . IMMUNOLOGY . vol. 135 , 109 - 109 .

Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Davies JE, Xu XY, Krams R et al. ( 2011 ) . Sequential Side Branch and Main Vessel Dilatation instead of Kissing Balloon after Provisional Bifurcation Stenting: Lessons from Micro-CT and Computational Simulations . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 58 , B82 - B82 .

Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW et al. ( 2010 ) . Multi-scale interaction of particulate flow and the artery wall . Medical Engineering & Physics vol. 33 , ( 7 ) 840 - 848 .

van Bochove GS, Paulis LEM, Segers D, Mulder WJM, Krams R, Nicolay K, Strijkers GJ ( 2010 ) . Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque . Contrast Media & Molecular Imaging vol. 6 , ( 1 ) 35 - 45 .

Debernardi N, Roijers RB, Krams R, De Crom R, Mutsaers PHA, Van Der Vusse GJ ( 2010 ) . Microcalcifications in atherosclerotic lesion of apolipoprotein E‐deficient mouse . International Journal of Experimental Pathology vol. 91 , ( 6 ) 485 - 494 .

Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Le Anh Luong, Mason J, Haskard DO, Carlsen H et al. ( 2010 ) . YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF-κB transcription factors . Heart vol. 96 , ( 17 )

Plata AM, Sherwin SJ, Krams R ( 2010 ) . Endothelial Nitric Oxide Production and Transport in Flow Chambers: The Importance of Convection . Annals of Biomedical Engineering vol. 38 , ( 9 ) 2805 - 2816 .

Helderman F, Manoch IJ, Breeuwer M, Kose U, Boersma H, van Sambeek MRHM, Pattynama PMT, Schouten O et al. ( 2010 ) . Predicting Patient-Specific Expansion of Abdominal Aortic Aneurysms . European Journal of Vascular and Endovascular Surgery vol. 40 , ( 1 ) 47 - 53 .

van Bochove GS, Straathof R, Krams R, Nicolay K, Strijkers GJ ( 2010 ) . MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque . Magnetic Resonance Materials in Physics, Biology and Medicine vol. 23 , ( 2 ) 77 - 84 .

Friedman MH, Krams R, Chandran KB ( 2010 ) . Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid–Structure Interactions . Annals of Biomedical Engineering vol. 38 , ( 3 ) 1178 - 1187 .

Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A et al. ( 2010 ) . c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis . Arteriosclerosis Thrombosis and Vascular Biology vol. 30 , ( 3 ) 546 - 553 .

Zakkar M, Punjabi P, Anderson J, Smith P, Krams R, Haskard D, Evans P ( 2010 ) . Dexamethasone arterializes venous endothelial cells by inducing MAP Kinase phosphatase-1 (MKP-1). A novel anti-inflammatory treatment for vein grafts . BRITISH JOURNAL OF SURGERY . vol. 97 , S12 - S13 .

da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopuloss N ( 2010 ) . Ex Vivo and In Vivo Regulation of Arginase in Response to Wall Shear Stress . vol. 29 , 753 - 756 .

Friedman MH, Krams R, Chandran KB ( 2010 ) . Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid-Structure Interactions . ANNALS OF BIOMEDICAL ENGINEERING . vol. 38 , 1178 - 1187 .

Pfenniger A, Galan K, Wong C, Cuhlmann S, Evans PC, Krams R, Kwak BR ( 2010 ) . Shear Stress Modulates the Expression of the Vasoprotective Protein Cx37 in Endothelial Cells . CIRCULATION . vol. 122 ,

Krams R, Cuhlmann S, Foin N, Evans P ( 2010 ) . Shear stress, inflammation and Atherosclerosis . Artery Research vol. 4 , ( 2 ) 41 - 46 .

Poelma C, Mari JM, Foin N, Tang M-X, Krams R, Caro CG, Weinberg PD, Westerweel J ( 2011 ) . 3D Flow reconstruction using ultrasound PIV . Experiments in Fluids . vol. 50 , 777 - 785 .

Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I et al. ( 2009 ) . Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State . Arteriosclerosis Thrombosis and Vascular Biology vol. 29 , ( 11 ) 1851 - 1857 .

De Zeeuw S, Trines SAIP, Krams R, Verdouw PD, Duncker DJ ( 2009 ) . Cardiovascular profile of the calcium sensitizer EMD 57033 in open‐chest anaesthetized pigs with regionally stunned myocardium . British Journal of Pharmacology vol. 129 , ( 7 ) 1413 - 1422 .

Cheng C, Tempel D, van Haperen R, van Damme L, Algür M, Krams R, de Crom R ( 2009 ) . Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype . Atherosclerosis vol. 204 , ( 1 ) 26 - 33 .

Zakkar M, van der Heiden K, Chaudhury H, Krams R, Haskard DO, Mason JC, Evans PC ( 2009 ) . ACTIVATION OF NF-E2 RELATED FACTOR-2 (NRF2) PROTECTS ARTERIES FROM EXHIBITING A PRO-INFLAMMATORY STATE . HEART . vol. 95 ,

Chaudhury HA, Zakkar M, Boyle J, Dennis J, van der Heiden K, Luong L, Cuhlmann S, Mason JM et al. ( 2009 ) . ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES . HEART . vol. 95 ,

Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason JM, Haskard DO, Krams R et al. ( 2009 ) . HIGH SHEAR STRESS SUPPRESSES THE EXPRESSION AND ACTIVITY OF NF-KAPPAB TRANSCRIPTION FACTORS IN ARTERIAL ENDOTHELIUM . HEART . vol. 95 ,

Foin N, Plata-Garcia A, Cuhlmann S, Evans P, Caro C, Krams R ( 2009 ) . SHEAR STRESS AND MASS TRANSPORT AFFECTS NFκB DYNAMICS IN ENDOTHELIAL CELLS . JOURNAL OF PHYSIOLOGICAL SCIENCES vol. 59 , 324 - 324 .

Foin N, Plata-Garcia A, Cuhlmann S, Evans PC, Caro CG, Krams R ( 2009 ) . SHEAR STRESS AND NITRIC OXIDE TRANSPORT AFFECT NF-KB DYNAMICS IN ENDOTHELIAL CELLS . HEART . vol. 95 ,

Foin N, Plata-Garcia A, Qin Q, Cuhlmann S, Evans PC, Caro CG, Krams R ( 2009 ) . Shear Stress and Nitric Oxide Transport Affect NF-κB Dynamics In Endothelial Cells . ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY . vol. 29 , E78 - E78 .

Susa D, van de Engel S, van Damme LCA, Roest HP, Krams R, IJzermans JNM, de Bruin RWF ( 2008 ) . Donor pre-treatment with tacrolimus reduces transplant vasculopathy . Pharmacological Research vol. 59 , ( 4 ) 273 - 278 .

Segers D, Weinberg P, Krams R ( 2008 ) . Atherosclerosis: cell biology and lipoproteins - shear stress and inflammation in plaque formation: new evidence . Current Opinion in Lipidology vol. 19 , ( 6 ) 627 - 628 .

Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ et al. ( 2008 ) . Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach . Vascular Disease Prevention vol. 2 , ( 1 ) 227 - 235 .

Krams R, Breeuwer M, van de Vosse F ( 2008 ) . Personalised imaging and biomechanical modelling of large vessels . Medical & Biological Engineering & Computing vol. 46 , ( 11 ) 1057 - 1058 .

Segers D, Garcia-Garcia HM, Cheng C, de Crom R, Krams R, Wentzel JJ, van der Steen AFW, Serruys PW et al. ( 2008 ) . A primer on the immune system in the pathogenesis and treatment of atherosclerosis . EuroIntervention vol. 4 , ( 3 ) 378 - 390 .

Robbers‐Visser D, Helderman F, Strengers JL, van Osch‐Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R et al. ( 2008 ) . Pulmonary artery size and function after Fontan operation at a young age . Journal of Magnetic Resonance Imaging vol. 28 , ( 5 ) 1101 - 1107 .

Robbers-Visser D, Helderman F, Strengers JL, van Osch-Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R et al. ( 2008 ) . 1057 Pulmonary artery size and function after Fontan operation at young age: assessment with phase contrast magnetic resonance imaging . Journal of Cardiovascular Magnetic Resonance vol. 10 , ( Suppl 1 )

Breeuwer M, de Putter S, Kose U, Speelman L, Visser K, Gerritsen F, Hoogeveen R, Krams R et al. ( 2008 ) . Towards patient-specific risk assessment of abdominal aortic aneurysm . Medical & Biological Engineering & Computing vol. 46 , ( 11 ) 1085 - 1095 .

de Crom R, Cheng C, Helderman F, Krams R ( 2008 ) . Large variations in absolute wall shear stress levels within one species and between species . Atherosclerosis vol. 204 , ( 1 ) 16 - 17 .

Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R et al. ( 2008 ) . Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis . Circulation Research vol. 103 , ( 7 ) 726 - 732 .

Ridger V, Krams R, Carpi A, Evans PC ( 2008 ) . Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update . Biomedicine & Pharmacotherapy vol. 62 , ( 8 ) 536 - 540 .

Zakkar M, Chaudhury H, Krams R, Mason JC, Clark AR, Haskard DO, Evans PC ( 2008 ) . MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS . Atherosclerosis . vol. 199 ,

de Bruin RWF, Susa D, van den Engel S, van Damme LA, Roest HP, Krams R, Jzermans JNMI ( 2008 ) . DONOR PRE-TREATMENT WITH TACROLIMUS EDUCES TRANSPLANT VASCULOPATHY . Transplantation vol. 86 , ( 2S )

da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopulos N ( 2008 ) . REGULATION OF ARGINASE IN RESPONSE SHEAR STRESS: NEW POTENTIAL THERAPEUTIC TARGET ATHEROSCLEROSIS? . Journal of Biomechanics vol. 41 ,

Helderman F, Manoch IJ, Breeuwer M, Kose U, Schouten O, van Sambeek MRM, Poldermans D, Pattynama PTM et al. ( 2008 ) . A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness . Medical & Biological Engineering & Computing vol. 46 , ( 11 )

Foin N, Evans P, Krams R ( 2008 ) . Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque . Current Opinion in Lipidology vol. 19 , ( 1 ) 98 - 100 .

da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopulos N ( 2008 ) . Modulation of arginase in response to wall shear stress . Artery Research vol. 2 , ( 3 ) 105 - 106 .

da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopulos N ( 2008 ) . Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis? . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 38 , 36 - 36 .

Cheng C, Tempel D, Oostlander A, Helderman F, Gijsen F, Wentzel J, van Haperen R, Haitsma DB et al. ( 2007 ) . Rapamycin modulates the eNOS vs. shear stress relationship . Cardiovascular Research vol. 78 , ( 1 ) 123 - 129 .

Segers D, de Crom R, Leenen P, Pasterkamp G, Krams R ( 2007 ) . Abstract 879: The Chemokine CXCL10 Is Involved In The Development Of Atherosclerotic Plaque Vulnerability . Circulation vol. 116 , ( suppl_16 )

Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC, Krams R ( 2007 ) . Effect of shear stress on vascular inflammation and plaque development . Current Opinion in Lipidology vol. 18 , ( 5 ) 527 - 533 .

Goertz DE, Frijlink ME, Tempel D, Krams R, De Jong N, van der Steen AF ( 2007 ) . Subharmonic Contrast Intravascular Ultrasound . 2014 IEEE International Ultrasonics Symposium . Conference: 2007 IEEE Ultrasonics Symposium Proceedings1065 - 1068 .

Goertz DE, Frijlink ME, Tempel D, Bhagwandas V, Gisolf A, Krams R, de Jong N, van der Steen AFW ( 2007 ) . Subharmonic Contrast Intravascular Ultrasound for Vasa Vasorum Imaging . Ultrasound in Medicine & Biology vol. 33 , ( 12 ) 1859 - 1872 .

Van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, Pourquie MJBM, Alkemade FE et al. ( 2007 ) . Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis . Atherosclerosis vol. 196 , ( 2 ) 542 - 550 .

Kofflard MJ, Michels M, Krams R, Kliffen M, Geleijnse ML, Cate FJT, Serruys PW ( 2007 ) . Coronary flow reserve in hypertrophic cardiomyopathy: relation with microvascular dysfunction and pathophysiological characteristics . Netherlands Heart Journal vol. 15 , ( 6 ) 209 - 215 .

Jackson CL, Bennett MR, Biessen EAL, Johnson JL, Krams R ( 2007 ) . Assessment of Unstable Atherosclerosis in Mice . Arteriosclerosis Thrombosis and Vascular Biology vol. 27 , ( 4 ) 714 - 720 .

Cheng C, Tempel D, van Haperen R, de Boer HC, Segers D, Huisman M, van Zonneveld AJ, Leenen PJM et al. ( 2007 ) . Shear stress–induced changes in atherosclerotic plaque composition are modulated by chemokines . Journal of Clinical Investigation vol. 117 , ( 3 ) 616 - 626 .

Goertz DE, Frijlink ME, Krams R, de Jong N, van der Steen AFW ( 2007 ) . Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound . Netherlands Heart Journal vol. 15 , ( 2 ) 77 - 80 .

Segers D, Helderman F, Cheng C, van Damme LCA, Tempel D, Boersma E, Serruys PW, de Crom R et al. ( 2007 ) . Gelatinolytic Activity in Atherosclerotic Plaques Is Highly Localized and Is Associated With Both Macrophages and Smooth Muscle Cells In Vivo . Circulation vol. 115 , ( 5 ) 609 - 616 .

Susa D, van den Engel S, van Damme LA, Roest HP, Krams R, IJiermans JNM, De Bruin RWF ( 2007 ) . Donor pre-treatment with tacrolimus reduces transplant vasculopathy . TRANSPLANT INTERNATIONAL . vol. 20 , 141 - 141 .

Da Silva RF, Gambillara V, Krams R, Stergiopulos N ( 2007 ) . Modulation of arginases by different patterns of shear stress: new signaling pathway in atherogenesis? . Computer Methods in Biomechanics & Biomedical Engineering vol. 10 , ( sup1 ) 77 - 78 .

da Silva RF, Gambillara V, Cheng C, Segers D, de Crom R, Krams R, Stergiopulos N ( 2007 ) . P.096 Role of Arginase Pathway in Response to Shear Stress: New Potential Therapeutic Targets for Atherosclerosis? . Artery Research vol. 1 , ( 2 ) 74 - 75 .

Thury A, Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW, Slager CJ ( 2007 ) . The Influence of Shear Stress on Restenosis . Essentials of Restenosis , Springer Nature

Segers D, de Crom R, Leenen P, Pasterkamp G, Krams R ( 2007 ) . The chemokine CXCL10 is involved in the development of atherosclerotic plaque vulnerability . CIRCULATION . vol. 116 , 172 - 172 .

FAN D, SOEI LK, SASSEN LMA, KRAMS R, HENDRIK E, VERDOUW PD ( 2006 ) . On the Reversal of Myocardial Stunning: A Role for Ca2+‐Sensitizers . Annals of the New York Academy of Sciences vol. 723 , ( 1 ) 364 - 367 .

Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, van Tol A, Duncker DJ et al. ( 2006 ) . Large variations in absolute wall shear stress levels within one species and between species . Atherosclerosis vol. 195 , ( 2 ) 225 - 235 .

Cheng C, Tempel D, van der Baan A, Krams R, Daemen MJAP, van Haperen R, Grosveld F, de Crom R ( 2006 ) . Response to Letter Regarding Article, “Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress” . Circulation vol. 114 , ( 22 )

Frijlink ME, Goertz DE, Vos HJ, Tesselaar E, Blacquière G, Gisolf A, Krams R, van der Steen AFW ( 2006 ) . Harmonic intravascular ultrasound imaging with a dual-frequency catheter . Ultrasound in Medicine & Biology vol. 32 , ( 11 ) 1649 - 1654 .

Frijlink ME, Goertz DE, van Damme LCA, Krams R, van der Steen AFW ( 2006 ) . Intravascular ultrasound tissue harmonic imaging in vivo . IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control vol. 53 , ( 10 ) 1844 - 1852 .

Cheng C, Tempel D, van Damme L, van Haperen R, Krams R, de Crom R ( 2006 ) . Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype . Vascular Pharmacology vol. 45 , ( 3 ) e91 - e92 .

Cheng C, Tempel D, van Damme L, van Haperen R, Krams R, de Crom R ( 2006 ) . Patterns of fluid shear stress determine atherosclerotic lesion size and vulnerability . Vascular Pharmacology vol. 45 , ( 3 )

Goertz DE, Frijlink ME, Tempel D, van Damme LCA, Krams R, Schaar JA, Cate FJT, Serruys PW et al. ( 2006 ) . Contrast Harmonic Intravascular Ultrasound . Investigative Radiology vol. 41 , ( 8 ) 631 - 638 .

Krams R, Cheng C, Helderman F, Verheye S, van Damme LCA, Mousavi Gourabi B, Tempel D, Segers D et al. ( 2006 ) . Shear stress is associated with markers of plaque vulnerability and MMP-9 activity . EuroIntervention vol. 2 , ( 2 ) 250 - 256 .

Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R, de Crom R ( 2006 ) . Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress . Circulation vol. 113 , ( 23 ) 2744 - 2753 .

Nette RW, Ie EHY, Vletter WB, Krams R, Weimar W, Zietse R ( 2006 ) . Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients . Nephrology Dialysis Transplantation vol. 21 , ( 5 ) 1305 - 1311 .

Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R, de Crom R ( 2006 ) . Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress . CIRCULATION vol. 113 , ( 23 ) 2744 - 2753 .

Lipton J, Segers D, Cheng C, Duckers H, Krams R, Tempel D, Busser E, De Kleijn D et al. ( 2006 ) . High IP-10 levels identify plaques with a vulnerable phenotype . CIRCULATION . vol. 114 , 287 - 288 .

Helderman F, Schouten O, Manoch I, Buffart H, van der Steen AFW, Krams R ( 2006 ) . Numerical model for predicting dilatation of an Abdominal Aortic Aneurysm (AAA) . Journal of Biomechanics vol. 39 ,

Krams R ( 2006 ) . Shear stress and atherosclerosis . Journal of Biomechanics vol. 39 ,

Krams R, Schaar J, Helderman F, Cheng C, Gourabi BM, van Damme LCA, Segers D, Regar E et al. ( 2006 ) . Visualization of the Vulnerable Plaque . Cardiovascular Research , Springer Nature

Davies PF, Spaan JA, Krams R ( 2005 ) . Shear Stress Biology of the Endothelium . Annals of Biomedical Engineering vol. 33 , ( 12 ) 1714 - 1718 .

Krams R, Verheye S, van Damme LCA, Tempel D, Gourabi BM, Boersma E, Kockx MM, Knaapen MWM et al. ( 2005 ) . In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity . European Heart Journal vol. 26 , ( 20 ) 2200 - 2205 .

Ie EHY, Krams R, Vletter WB, Nette RW, Weimar W, Zietse R ( 2005 ) . Myocardial contractility does not determine the haemodynamic response during dialysis . Nephrology Dialysis Transplantation vol. 20 , ( 11 ) 2465 - 2471 .

Cheng C, van Haperen R, de Waard M, van Damme LCA, Tempel D, Hanemaaijer L, van Cappellen GWA, Bos J et al. ( 2005 ) . Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique . Blood vol. 106 , ( 12 ) 3691 - 3698 .

Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ et al. ( 2005 ) . Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach . Vascular Disease Prevention vol. 2 , ( 3 ) 227 - 235 .

Krams R, Bambi G, Guidi F, Helderman F, van der Steen AFW, Tortoli P ( 2005 ) . Effect of vessel curvature on Doppler derived velocity profiles and fluid flow . Ultrasound in Medicine & Biology vol. 31 , ( 5 ) 663 - 671 .

Wentzel JJ, Krams R, Slager CJ ( 2005 ) . Letter Regarding Article by Korshunov and Berk, “Strain-Dependent Vascular Remodeling: The ‘Glagov Phenomenon’ Is Genetically Determined” . Circulation vol. 111 , ( 9 ) e119 - e119 .

Schaar* JA, de Korte* CL, Mastik F, van Damme LCA, Krams R, Serruys PW, van der Steen AFW ( 2005 ) . Three-Dimensional Palpography of Human Coronary Arteries . Herz vol. 30 , ( 2 ) 125 - 133 .

Cheng C, Tempel D, van Damme L, van Gaalen K, van Haperen R, Krams R, de Crom R ( 2005 ) . Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype in apoE KO mice . CIRCULATION . vol. 112 , U221 - U221 .

Susa D, de Engel SV, van Damme LCA, Roest HP, Krams R, Ijzermans JNM, de Bruin RWF ( 2005 ) . Donor pre-treatment with tacrolimus reduces matrix metallo proteinase activity and transplant arteriosclerosis . AMERICAN JOURNAL OF TRANSPLANTATION . vol. 5 , 442 - 443 .

Cheng C, Tempel D, van Damme L, van Haperen R, Krams R, de Crom R ( 2005 ) . Patterns of fluid shear stress determine Atherosclerotic lesion size and vulnerability . CIRCULATION . vol. 112 , U347 - U347 .

Cheng C, Tempel D, van Haperen R, de Crom R, Krams R ( 2005 ) . Vulnerable lesions induced by low shear stress are characterized by expression of specific inflammatory chemokines . CIRCULATION . vol. 112 , U136 - U136 .

Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, Serruys PW, De Feyter PJ, Slager CJ ( 2004 ) . Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries . Journal of Biomechanics vol. 38 , ( 7 ) 1551 - 1555 .

Krams R, Cate FJT, Carlier SG, van der Steen AFW, Serruys PW ( 2004 ) . Diastolic coronary vascular reserve: a new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy . Journal of the American College of Cardiology vol. 43 , ( 4 ) 670 - 677 .

Cheng C, van Haperen R, de Waard M, de Crom R, Krams R ( 2004 ) . In vivo induced changes in shear stress patterns affect the expression and the intracellular localization of endothelial nitric oxide synthase . EUROPEAN HEART JOURNAL . vol. 25 , 58 - 58 .

Cheng C, de Waard M, van Haperen R, Tempel D, van der Baan A, Krams R, de Crom R ( 2004 ) . In vivo induction of low shear stress and oscillatory shear stress causes atherosclerosis . CIRCULATION . vol. 110 , 39 - 39 .

Frijlink ME, Goertz DE, Van Damme LCA, Krams R, Van Der Steen AFW ( 2004 ) . Intravascular Ultrasound Tissue Harmonic Imaging In Vivo . Conference: IEEE Ultrasonics Symposium, 2004 vol. 2 , 1118 - 1121 .

Verheye S, De Meyer GRY, Krams R, Kockx MM, Van Damme LCA, Gourabi BM, Knaapen MWM, Van Langenhove G et al. ( 2004 ) . Intravascular thermography: Immediate functional and morphological vascular findings . European Heart Journal vol. 25 , ( 2 ) 158 - 165 .

van Ooijen PMA, Irwan R, Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R et al. ( 2004 ) . Multi-Dimensional Computed Coronary Visualization . Coronary Radiology , Springer Nature

Cheng C, de Crom R, van Haperen R, Helderman F, Gourabi BM, van Damme LCA, Kirschbaum SW, Slager CJ et al. ( 2004 ) . The role of shear stress in atherosclerosis . Cell Biochemistry and Biophysics vol. 41 , ( 2 ) 279 - 294 .

van Haperen R, Cheng C, Mees BME, van Deel E, de Waard M, van Damme LCA, van Gent T, van Aken T et al. ( 2003 ) . Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic Mice . American Journal Of Pathology vol. 163 , ( 4 ) 1677 - 1686 .

Diamantopoulos L, Liu X, De Scheerder I, Krams R, Li S, Van Cleemput J, Desmet W, Serruys PW ( 2003 ) . The effect of reduced blood-flow on the coronary wall temperatureAre significant lesions suitable for intravascular thermography? . European Heart Journal vol. 24 , ( 19 ) 1788 - 1795 .

de Feyter PJ, Serruys PW, Nieman K, Mollet N, Cademartiri F, van Geuns RJ, Slager C, van der Steen AFW et al. ( 2003 ) . Imaging of coronary atherosclerosis and identification of the vulnerable plaque . Netherlands Heart Journal vol. 11 , ( 9 ) 347 - 358 .

Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ, Slager CJ ( 2003 ) . Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling . Circulation vol. 108 , ( 1 ) 17 - 23 .

Carlier SG, van Damme LCA, Blommerde CP, Wentzel JJ, van Langehove G, Verheye S, Kockx MM, Knaapen MWM et al. ( 2003 ) . Augmentation of Wall Shear Stress Inhibits Neointimal Hyperplasia After Stent Implantation . Circulation vol. 107 , ( 21 ) 2741 - 2746 .

Wentzel JJ, Gijsen FJH, Stergiopulos N, Serruys PW, Slager CJ, Krams R ( 2003 ) . Shear stress, vascular remodeling and neointimal formation . Journal of Biomechanics vol. 36 , ( 5 ) 681 - 688 .

KRAMS R, SEGERS D, GOURABI BM, MAAT W, CHENG C, VAN PELT C, VAN DAMME LCA, DE FEYTER P et al. ( 2003 ) . Inflammation and Atherosclerosis: . Journal of Interventional Cardiology vol. 16 , ( 2 ) 107 - 113 .

KRAMS R ( 2003 ) . 929 Plaque temperature heterogeneity is associated with macrophage accumulation and metalloproteinase activity . European Heart Journal . vol. 24 ,

GOURABI B ( 2003 ) . P1760 Local macrophage accumulation in atherosclerotic rabbit aortas as determined by a novel three-dimensional histology technique . European Heart Journal . vol. 24 ,

KRAMS R ( 2003 ) . P2207 High shear stress is predictive for markers of plaque inflammation . European Heart Journal . vol. 24 ,

KRAMS R ( 2003 ) . P2242 Augmentation of wall shear stress inhibits neo intimal hyperplasia and inflammation after stent implantation . European Heart Journal . vol. 24 ,

Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW et al. ( 2003 ) . Coronary 3-D angiography, 3-D ultrasound and their fusion . Vascular Ultrasound , Springer Nature

Schaar JA, van der Steen AFW, Arampatzis CA, Krams R, Slager CJ, ten Have AG, van de Poll SW, Gijsen FJ et al. ( 2003 ) . Diagnosis of vulnerable plaques in the cardiac catheterization laboratory . Vascular Ultrasound , Springer Nature

Wentzel JJ, Cheng C, de Crom R, Stergiopulos N, Serruys PW, Slager CJ, Krams R ( 2003 ) . Shear stress and the IVUS derived vessel wall thickness . Vascular Ultrasound , Springer Nature

Krams R, van Damme L, Tempel D, Gourabi BM, van der Steen AF ( 2003 ) . Shear stress is associated with markers of plaque vulnerability . CIRCULATION . vol. 108 , 225 - 225 .

Cheng C, van Haperen R, de Waard M, de Crom R, Krams R ( 2003 ) . eNOS expression responds to changes in shear stress: Direct demonstration in a novel in vivo mouse model . CIRCULATION . vol. 108 , 151 - 151 .

Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Sianos G, Wentzel JJ et al. ( 2002 ) . High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization . American Heart Journal vol. 144 , ( 1 ) 136 - 143 .

Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW et al. ( 2002 ) . Focal In-Stent Restenosis Near Step-Up . Circulation vol. 105 , ( 23 ) 185e - 1187 .

Wentzel JJ, Janssen EH, Krams R, Schuurbiers JCH, van der Giessen WJ, Serruys PW, de Feyter PJ, Slager CJ ( 2002 ) . Determination of shear stress in patients confirms that lumen preservation in atherosclerosis is associated with shear stress regulation . Journal of the American College of Cardiology . vol. 39 ,

Trines SAIP, Smits CAG, van der Moer J, Slager CJ, Verdouw PD, Krams R ( 2002 ) . Calcium Sensitizer EMD 57033, But Not the β 1 -Adrenoreceptor Agonist Dobutamine, Increases Mechanical Efficiency in Stunned Myocardium . Journal of Cardiovascular Pharmacology vol. 39 , ( 1 ) 61 - 72 .

Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW et al. ( 2002 ) . Focal in-stent restenosis near step-up - Roles of low and oscillating shear stress? . CIRCULATION vol. 105 , ( 23 ) E185 - E187 .

Ie EHY, Krams R, Vletter WB, ten Cate FJ, Nette RW, Weimar W, Zietse R ( 2002 ) . Reduced end-systolic elastance indicating poor left ventricular contractility in hemodialysis patients . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 13 , 213A - 213A .

Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ, Slager CJ ( 2002 ) . The relationship between wall thickness and shear stress in coronary arteries of patients . EUROPEAN HEART JOURNAL . vol. 23 , 415 - 415 .

de Korte CL, Schaar JA, Mastik F, van Damme LCA, Krams R, Serruys PW, van der Steen AFW ( 2002 ) . Vulnerable plaque detection with 3-dimensional palpography . CIRCULATION . vol. 106 , 1 - 2 .

Thury A, Wentzel JJ, Schuurbiers JCH, Ligthart JMR, Krams R, de Feyter PJ, Serruys PW, Slager CJ ( 2001 ) . Prominent Role of Tensile Stress in Propagation of a Dissection After Coronary Stenting . Circulation vol. 104 , ( 11 ) e53 - e54 .

Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P, Westerhof N ( 2001 ) . Decrease in coronary vascular volume in systole augments cardiac contraction . AJP Heart and Circulatory Physiology vol. 281 , ( 2 ) h731 - h737 .

Wentzel JJ, Kloet J, Andhyiswara I, Oomen JAF, Schuurbiers JCH, de Smet BJGL, Post MJ, de Kleijn D et al. ( 2001 ) . Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty . Circulation vol. 104 , ( 1 ) 91 - 96 .

Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD, Krams R ( 2001 ) . Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency . Cardiovascular Research vol. 51 , ( 1 ) 122 - 130 .

Wentzel JJ, Krams R, Schuurbiers JCH, Oomen JA, Kloet J, van der Giessen WJ, Serruys PW, Slager CJ ( 2001 ) . Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries . Circulation vol. 103 , ( 13 ) 1740 - 1745 .

Carlier SG, van Damme LC, Blommerde CP, Van Langenhove G, Wentzel JJ, van der Giessen WJ, Verdouw PD, Krams R et al. ( 2001 ) . An increased wall shear stress inhibits neointimal hyperplasia after stent implantation: preliminary in vivo experience of the ARED flow divider in a rabbit model of restenosis . EUROPEAN HEART JOURNAL . vol. 22 , 278 - 278 .

Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P, Westerhof N ( 2001 ) . Decrease in coronary vascular volume in systole augments cardiac contraction . American Journal of Physiology - Heart and Circulatory Physiology vol. 281 , ( 2 50-2 )

Krams R, van Damme LCA, Wentzel JJ, De Crom R, Haperen R, Van Aken T ( 2001 ) . Functional assessment of eNOS transgenesis in mice aortas . EUROPEAN HEART JOURNAL . vol. 22 , 60 - 60 .

Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Wentzel JJ, Krams R et al. ( 2001 ) . High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 37 , 16A - 17A .

Thury A, Wentzel JJ, Janssen EH, Krams R, Oomen JA, Schuurbiers JCH, Ligthart JMR, Serruys PW et al. ( 2001 ) . Novel method for in vivo calculation of absolute sheer stress at any location of a stented human coronary artery . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 37 , 298A - 299A .

Wolters B, Slager C, Gijsen F, Wentzel J, Krams R, van FDV ( 2001 ) . On the Numerical Analysis of Coronary Artery Wall Shear Stress . Conference: Computers in Cardiology 2001. Vol.28 (Cat. No.01CH37287)169 - 172 .

Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD, Krams R ( 2001 ) . Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency . EUROPEAN HEART JOURNAL . vol. 22 , 516 - 516 .

Wentzel JJ, Whelan DM, van der Giessen WJ, van Beusekom HMM, Andhyiswara I, Serruys PW, Slager CJ, Krams R ( 2000 ) . Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution . Journal of Biomechanics vol. 33 , ( 10 ) 1287 - 1295 .

Trines SAIP, Slager CJ, Van der Moer J, Verdouw PD, Krams R ( 2000 ) . Efficiency of energy transfer, but not external work, is maximized in stunned myocardium . AJP Heart and Circulatory Physiology vol. 279 , ( 3 ) h1264 - h1273 .

de Zeeuw S, Trines SAIP, Krams R, Duncker DJ, Verdouw PD ( 2000 ) . In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca2+ in stunned myocardium . European Journal of Pharmacology vol. 403 , ( 1-2 ) 99 - 109 .

Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Kloet J, Krams R, von Birgelen C, van der Giessen WJ et al. ( 2000 ) . True 3-Dimensional Reconstruction of Coronary Arteries in Patients by Fusion of Angiography and IVUS (ANGUS) and Its Quantitative Validation . Circulation vol. 102 , ( 5 ) 511 - 516 .

Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN, Serruys PW ( 2000 ) . Helical Velocity Patterns in a Human Coronary Artery . Circulation vol. 102 , ( 3 ) e22 - e24 .

Bom N, de Korte CL, Wentzel JJ, Krams R, Carlier SG, van der Steen AWF, Slager CJ, Roelandt JRTC ( 2000 ) . Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging . Clinical Research in Cardiology vol. 89 , ( Suppl 2 ) s105 - s111 .

Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Sipkema P, Westerhof N ( 2000 ) . Coronary systolic flow impediment is functional in cardiac contraction . EUROPEAN HEART JOURNAL . vol. 21 , 667 - 667 .

Trines SAIP, Slager CJ, Van Der Moer J, Verdouw PD, Krams R ( 2000 ) . Efficiency of energy transfer, but not external work, is maximized in stunned myocardium . American Journal of Physiology - Heart and Circulatory Physiology vol. 279 , ( 3 48-3 )

Soei LK, de Zeeuw S, Krams R, Duncker DJ, Verdouw PD ( 1999 ) . Ca2+ sensitization and diastolic function of normal and stunned porcine myocardium . European Journal of Pharmacology vol. 386 , ( 1 ) 55 - 67 .

Krams R, Wentzel JJ, Cespedes I, Vinke R, Carlier S, van der Steen AFW, Lancee CT, Slager CJ ( 1999 ) . Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system . Ultrasound in Medicine & Biology vol. 25 , ( 5 ) 803 - 810 .

Trines SA, Van der Moer J, Krams R, Slager CJ, Van Meegen JR, Verdouw PD ( 1999 ) . External work recruitment can be restored in stunned myocardium without increasing oxygen consumption using EMD 57033, a calcium sensitizer . CIRCULATION . vol. 100 , 8 - 8 .

Wentzel JJ, Kloet J, Krams R, Serruys PW, Slager CJ ( 1999 ) . The relationship between neo intimal thickness and shear stress after wallstent implantation in human coronary arteries at 6 months follow up . CIRCULATION . vol. 100 , 727 - 727 .

Oomen JA, Trines SAIP, Vermeulen WB, Krams R, Schuurbiers JCH, Vletter WB, Roelandt JRTC, Slager CJ ( 1999 ) . Towards assessment of regional wall stress of the left ventricle using 3D ultrasound imaging . Computers in Cardiology 2000 Vol27 (Cat 00CH37163) . Conference: Computers in Cardiology 1999. Vol.26 (Cat. No.99CH37004)129 - 132 .

Osterop APRM, Kofflard MJM, Sandkuijl LA, Cate FJT, Krams R, Schalekamp MADH, Danser AHJ ( 1998 ) . AT1 Receptor A/C1166 Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy . Hypertension vol. 32 , ( 5 ) 825 - 830 .

Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B et al. ( 1998 ) . Shear stress in atherosclerosis, and vascular remodelling . Seminars in interventional cardiology vol. 3 , ( 1 ) 39 - 44 .

van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Roelandt JRT, Bom N ( 1998 ) . Cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium . European Journal of Ultrasound vol. 7 ,

Krams R, Kofflard MJM, Duncker DJ, Von Birgelen C, Carlier S, Kliffen M, Cate FJT, Serruys PW ( 1998 ) . Decreased Coronary Flow Reserve in Hypertrophic Cardiomyopathy Is Related to Remodeling of the Coronary Microcirculation . Circulation vol. 97 , ( 3 ) 230 - 233 .

Osterop APRM, Kofflard MJM, Sandkuijl LA, Ten Cate FJ, Krams R, Schalekamp MADH, Danser AHJ ( 1998 ) . AT<inf>1</inf> receptor A/C¹¹⁶⁶ polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy . Hypertension vol. 32 , ( 5 ) 825 - 830 .

van der Steen AFW, Cespedes EI, de Korte CL, Carlier SG, Li W, Mastik F, Lancee CT, Borsbroom J et al. ( 1998 ) . Novel developments in intravascular imaging . 2014 IEEE International Ultrasonics Symposium . Conference: 1998 IEEE Ultrasonics Symposium. Proceedings (Cat. No. 98CH36102) vol. 2 ,

Stager CJ, Wentzel JJ, Schuurbiers JC, Oomen JA, Krams R, Achterberg H, Kloet J, deFeyter PJ ( 1998 ) . True 3-D reconstruction of coronary arteries in patients shows accurate correspondence between x-ray and IVUS derived dimensions . CIRCULATION . vol. 98 , 508 - 509 .

Dongsheng FA, Kie Soei LO, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams ROB ( 1997 ) . Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium . American Journal of Physiology - Heart and Circulatory Physiology vol. 42 , ( 5 )

Krams R, Wentzel JJ, Oomen J, Schuurbier J, Vinke R, Slager CJ ( 1997 ) . Evidence for a pivotal role of shear stress on the endothelium in human atherosclerosis . Endothelium: Journal of Endothelial Cell Research . vol. 5 ,

Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams R ( 1997 ) . Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium . American Journal of Physiology vol. 273 , ( 5 ) h2146 - h2154 .

Krams R, Wentzel JJ, Oomen JAF, Vinke R, Schuurbiers JCH, de Feyter PJ, Serruys PW, Slager CJ ( 1997 ) . Evaluation of Endothelial Shear Stress and 3D Geometry as Factors Determining the Development of Atherosclerosis and Remodeling in Human Coronary Arteries in Vivo . Arteriosclerosis Thrombosis and Vascular Biology vol. 17 , ( 10 ) 2061 - 2065 .

van Blankenstein JH, Slager CJ, Soei LK, Boersma H, Stijnen T, Schuurbiers JCH, Krams R, Lachmann B et al. ( 1997 ) . Cardiac depression after experimental air embolism in pigs: role of addition of a surface-active agent1 . Cardiovascular Research vol. 34 , ( 3 ) 473 - 482 .

Slager CJ, Wentzel JJ, Oomen JA, Schuurbiers JC, Krams R, von Birgelen C, Tjon A, Serruys PW et al. ( 1997 ) . True reconstruction of vessel geometry from combined X-ray angiographic and intracoronary ultrasound data . Seminars in interventional cardiology vol. 2 , ( 1 ) 43 - 47 .

Wentzel JJ, Krams R, Oomen JAF, Schuurbiers JCH, Vinke R, Bom N, Slager CJ ( 1997 ) . Applying computational fluid dynamics to a spatially correct 3D reconstruction of a coronary arterial segment in the individual patient . Conference: Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society vol. 3 ,

Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams R ( 1997 ) . Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium . American Journal of Physiology - Heart and Circulatory Physiology vol. 273 , ( 5 42-5 )

Wentzel JJ, Krams R, van der Steen AFW, Li W, Cespedes E, Bom N, Slager CJ ( 1997 ) . Disturbance of 3D velocity profiles induced by an IVUS catheter: evaluation with computational fluid dynamics . Computers in Cardiology 2000 Vol27 (Cat 00CH37163) . Conference: Computers in Cardiology 1997597 - 600 .

van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Verdouw PD, Roelandt JRTC, Bom N ( 1997 ) . Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium . Ultrasound in Medicine & Biology vol. 23 , ( 3 ) 405 - 414 .

deZeeuw S, Soei L, vanMeegen JR, Trines SA, Krams R, Duncker DJ, Verdouw PD ( 1997 ) . Recovery of systolic function of stunned myocardium by the Ca2+-sensitizer EMD 57033 is not accompanied by impairment of diastolic function . CIRCULATION . vol. 96 , 1109 - 1109 .

Wentzel JJ, Krams R, vanBeusekom HMN, Whelan DM, vanderGeissen WJ, Krabbendam SC, Andhyiswara I, Tjien ATJ et al. ( 1997 ) . Stent implantation causes alterations in 3D-geometry and 3D-shear stress distribution at the endothelium of coronary arteries . CIRCULATION . vol. 96 , 2349 - 2349 .

Soei LK, Krams R, Duncker DJ, Verdouw PD ( 1996 ) . The ca²⁺ sensmser emd 60263 only impairs diastolic function of stunned myocardium at high doses in anesthetized swine . FASEB Journal . vol. 10 ,

Bezstarosti K, Soei LK, Krams R, Cate FJT, Verdouw PD, Lamers JMJ ( 1996 ) . The effect of a thiadiazinone derived Ca2+ sensitizer on the responsiveness of Mg2+-ATPase to Ca2+ in myofibrils isolated from stunned and nonstunned porcine and human myocardium . Biochemical Pharmacology vol. 51 , ( 9 ) 1211 - 1220 .

Rijsterborgh H, van der Steen AFW, Krams R, Mastik F, Lancee CT, Verdouw PD, Roelandt JRTC, Bom N ( 1996 ) . The relationship between myocardial integrated backscatter, perfusion pressure and wall thickness during isovolumic contraction: An isolated pig heart study . Ultrasound in Medicine & Biology vol. 22 , ( 1 ) 43 - 52 .

Di Mario C, Gil R, Krams R, De Feyter PJ, Serruys W ( 1995 ) . New invasive techniques of assessment of the physiological significance of coronary stenoses in humans . European Heart Journal vol. 16 Suppl I , ( suppl I ) 104 - 114 .

Fan D ( 1995 ) . Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency . Cardiovascular Research vol. 29 , ( 3 ) 428 - 437 .

Slager CJ, Laban M, von Birgelen C, Krams R, Oomen JAF, Boer AD, Wenguang L, de Feyter PJ et al. ( 1995 ) . 734-6 ANGUS: A New Approach to Three-dimensional Reconstruction of Geometry and Orientation of Coronary Lumen and Plaque by Combined Use of Coronary Angiography and IVUS . Journal of the American College of Cardiology vol. 25 , ( 2 )

Laban M, Oomen JA, Slager CJ, Wentzel JJ, Krams R, Schuurbiers JCH, Beer AD, von Birgelen C et al. ( 1995 ) . ANGUS: a new approach to three-dimensional reconstruction of coronary vessels by combined use of angiography and intravascular ultrasound . Conference: Computers in Cardiology 1995325 - 328 .

VONBIRGELEN C, KRAMS R, GIL R, TENGATE FJ, DIMARIO C ( 1995 ) . HOW SHOULD WE EVALUATE THE VASODILATORY CAPACITY OF CORONARY RESISTANCE VESSELS IN PATIENTS WITH ASYMMETRIC HYPERTROPHIC CARDIOMYOPATHY . CIRCULATION . vol. 92 , 960 - 960 .

VONBIRGELEN C, KRAMS R, DIMARIO C, GIL R, KOFFLARD M, TENCATE FJ, REIMERS B, SLAGER CJ et al. ( 1995 ) . SYSTEMATIC STUDY OF FLOW VELOCITY PROFILES IN EPICARDIAL CORONARY-ARTERIES OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND SUBAORTIC OUTFLOW GRADIENT . CIRCULATION . vol. 92 , 1549 - 1549 .

Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ, Verdouw PD ( 1994 ) . Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship . American Journal of Physiology vol. 267 , ( 4 ) h1557 - h1564 .

Fan D, Soei LK, Sassen LM, Krams R, Verdouw PD ( 1994 ) . Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency . Cardiovascular Research vol. 28 , ( 9 ) 428 - 437 .

Di Mario C, Krams R, Gil R, Serruys PW ( 1994 ) . Slope of the instantaneous hyperemic diastolic coronary flow velocity-pressure relation. A new index for assessment of the physiological significance of coronary stenosis in humans . Circulation vol. 90 , ( 3 ) 1215 - 1224 .

Soei LK, Sassen LM, Fan DS, van Veen T, Krams R, Verdouw PD ( 1994 ) . Myofibrillar Ca2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium . Circulation vol. 90 , ( 2 ) 959 - 969 .

Fan D, Kie Soei L, Sassen LMA, Krams R, Hendrik E, Verdouw PD ( 1994 ) . On the Reversal of Myocardial Stunning: A Role for Ca2+-Sensitizers . Ann N Y Acad Sci vol. 723 , ( 1 ) 364 - 367 .

Fan D, Sassen LMA, Trines SAIP, Soei LK, Krams R, Verdouw PD ( 1994 ) . Increasing the Ca⁺⁺ sensitivity reverses the increased afterload dependency of external work and the efficiency of energy conversion of stunned myocardium . Applied Cardiopulmonary Pathophysiology vol. 5 , ( 2 ) 63 - 72 .

KRAMS R, JANSSEN M, VANDERLEE C, VANMEEGEN J, DEJONG JW, SLAGER CJ, VERDOUW PD ( 1994 ) . LOSS OF ELASTIC RECOIL IN POSTISCHEMIC MYOCARDIUM INDUCES RIGHTWARD SHIFT OF THE SYSTOLIC PRESSURE-VOLUME RELATIONSHIP . AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY vol. 267 , ( 4 ) H1557 - H1564 .

Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ, Verdouw PD ( 1994 ) . Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship . American Journal of Physiology - Heart and Circulatory Physiology vol. 267 , ( 4 36-4 )

FAN DS, KRAMS R, SOEI LK, SASSEN LMA, VERDOUW PD ( 1994 ) . REVERSAL OF INCREASED LOAD-DEPENDENCY OF EFFICIENCY OF ENERGY-CONVERSION IN STUNNED MYOCARDIUM BY INCREASING THE CA2+ SENSITIVITY . CIRCULATION . vol. 90 , 645 - 645 .

Di Mario C, Krams R, Gil R, Meneveau N, Serruys PW ( 1994 ) . The instantaneous hyperemic pressure-flow relationship in conscious humans . Progress in quantitative coronary arteriography , vol. 155 , Springer Nature

FAN DS, KRAMS R, SOEI LK, SASSEN LMA, VERDOUW PD ( 1994 ) . VARIABILITY IN OXYGEN-CONSUMPTION MEASUREMENTS DURING MYOCARDIAL STUNNING CAN BE EXPLAINED BY A PRONOUNCED AFTERLOAD DEPENDENCY OF SEGMENT LENGTH SHORTENING, EXTERNAL WORK AND MECHANICAL EFFICIENCY . CIRCULATION . vol. 90 , 645 - 645 .

Krams R, Soei LK, McFalls EO, Prins EAW, Sassen LM, Verdouw PD ( 1993 ) . End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation . American Journal of Physiology vol. 265 , ( 6 ) h2099 - h2109 .

Koning MMG, Krams R, Xiao CS, van Meegen JR, Bezstarosti K, Lamers JMJ, Verdouw PD ( 1993 ) . Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia . Cardiovascular Drugs and Therapy vol. 7 , ( 5 ) 801 - 807 .

Duncker DJ, Sassen LMA, Bartels GL, van Meegen JR, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ et al. ( 1993 ) . L-Propionylcarnitine Does Not Affect Myocardial Metabolic or Functional Response to Chronotropic and Inotropic Stimulation After Repetitive Ischemia in Anesthetized Pigs . Journal of Cardiovascular Pharmacology vol. 22 , ( 3 ) 488 - 498 .

Krams R, Duncker DJ, McFalls EO, Hogendoorn A, Verdouw PD ( 1993 ) . Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium . Cardiovascular Research vol. 27 , ( 5 ) 740 - 747 .

McFalls EO, Duncker DJ, Sassen LM, Krams R, Man in't Veld AJ, Ruffolo RR, Verdouw PD ( 1993 ) . Altered coronary flow reserve in the hypertrophied heart: implications for therapy . Journal of Human Hypertension vol. 7 Suppl 1 , s29 - s36 .

Bruining N, Krams R, Passchier H, Meij S, de Feijter P, Keane D ( 1993 ) . A modular hard and software system for the analysis of cardiac signals: application to real time pressure-volume loops . Conference: Proceedings of Computers in Cardiology Conference161 - 164 .

DIMARIO C, KRAMS R, BALK A, VERDOUW PD, ROELANDT J ( 1993 ) . CAN THE ZERO-FLOW PRESSURE BE EXTRAPOLATED FROM THE FLOW VELOCITY-PRESSURE RELATION DURING LONG DIASTOLIC PAUSES IN HUMANS . CIRCULATION . vol. 88 , 204 - 204 .

Krams R, Duncker DJ, McFalls EO, Hogendoorn A, Verdouw PD ( 1993 ) . Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium . Cardiovascular Research vol. 27 , ( 5 ) 740 - 747 .

KRAMS R, SOEI LK, MCFALLS EO, PRINS EAW, SASSEN LMA, VERDOUW PD ( 1993 ) . END-SYSTOLIC PRESSURE LENGTH RELATIONS OF STUNNED RIGHT-AND-LEFT-VENTRICLES AFTER INOTROPIC STIMULATION . AMERICAN JOURNAL OF PHYSIOLOGY vol. 265 , ( 6 ) H2099 - H2109 .

Krams R, Loe Kie Soei, McFalls EO, Prins EAW, Sassen LMA, Verdouw PD ( 1993 ) . End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation . American Journal of Physiology - Heart and Circulatory Physiology vol. 265 , ( 6 34-6 )

De Jong JW, Huizer T, Janssen M, Krams R, Tavenier M, Verdouw PD ( 1993 ) . High-energy phosphates and their catabolites . Ischemia-reperfusion in cardiac surgery , vol. 142 , Springer Nature

McFalls EO, Duncker DJ, Krams R, Sassen LM, Hoogendoorn A, Verdouw PD ( 1992 ) . Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium . American Journal of Physiology vol. 263 , ( 6 ) h1724 - h1731 .

Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ, Verdouw PD ( 1992 ) . L-propionylcarnitine and myocardial performance in stunned porcine myocardium . Molecular and Cellular Biochemistry vol. 116 , ( 1-2 ) 147 - 153 .

Duncker DJ, McFalls EO, Krams R, Verdouw PD ( 1992 ) . Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium . American Journal of Physiology vol. 262 , ( 6 ) h1744 - h1751 .

Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A, Kie Soei L ( 1992 ) . Amiodarone increases ATP and decreases NaK ATPase activity and protein content of cultured rat heart myocytes . Journal of Molecular and Cellular Cardiology vol. 24 ,

Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A, Soei LK ( 1992 ) . Inotropic stimulation restores efficiency of energy transfer from pressure-segment length area to external mechanical work in stunned porcine myocardium . Journal of Molecular and Cellular Cardiology vol. 24 ,

Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ, Verdouw PD ( 1992 ) . L-propionylcarnitine and myocardial performance in stunned porcine myocardium . Lipid Metabolism in the Healthy and Disease Heart , Springer Nature

DUNCKER DJ, MCFALLS EO, KRAMS R, VERDOUW PD ( 1992 ) . PRESSURE-MAXIMAL CORONARY FLOW RELATIONSHIP IN REGIONALLY STUNNED PORCINE MYOCARDIUM . AMERICAN JOURNAL OF PHYSIOLOGY vol. 262 , ( 6 ) H1744 - H1751 .

Duncker DJ, McFalls EO, Krams R, Verdouw PD ( 1992 ) . Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium . American Journal of Physiology - Heart and Circulatory Physiology vol. 262 , ( 6 31-6 )

MCFALLS EO, DUNCKER DJ, KRAMS R, SASSEN LMA, HOOGENDOORN A, VERDOUW PD ( 1992 ) . RECRUITMENT OF MYOCARDIAL WORK AND METABOLISM IN REGIONALLY STUNNED PORCINE MYOCARDIUM . AMERICAN JOURNAL OF PHYSIOLOGY vol. 263 , ( 6 ) H1724 - H1731 .

MCFALLS EO, KRAMS R, DUNCKER DJ, SASSEN LMA, HOOGENDOORN A, VERDOUW PD ( 1992 ) . RECRUITMENT OF REGIONAL EXTERNAL WORK AND OXYGEN-CONSUMPTION IN STUNNED PORCINE MYOCARDIUM . CIRCULATION . vol. 86 , 613 - 613 .

McFalls EO, Duncker DJ, Krams R, Sassen LMA, Hoogendoorn A, Verdouw PD ( 1992 ) . Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium . American Journal of Physiology - Heart and Circulatory Physiology vol. 263 , ( 6 32-6 )

McFalls EO, Duncker DJ, Krams R, Ward H, Gornick C, Verdouw PD ( 1991 ) . Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine . Cardiovascular Research vol. 25 , ( 8 ) 659 - 665 .

Krams R, Duncker DJ, McFalls EO, Verdouw PD ( 1991 ) . Changes in oxygen-pressure volume area's (O2-PVA) studied after brief periods of ischemia . Journal of Molecular and Cellular Cardiology vol. 23 ,

Krams R, Duncker DJ, McFalls EO, Verdouw PD ( 1991 ) . Elastic recoil: A sensitive measure of loss of function during brief periods of ischemia and reperfusion . Journal of Molecular and Cellular Cardiology vol. 23 ,

Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD, Roelandt J ( 1991 ) . Does intravenous milrinone have a direct effect on diastolic function? . Am Heart J vol. 121 , ( 6 Pt 2 ) 1951 - 1955 .

Mcfalls EO, Duncker DJ, Krams R, Ward H, Gornick C, Verdouw PD ( 1991 ) . Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine . Cardiovascular Research vol. 25 , ( 8 ) 659 - 665 .

KRAMS R, MCFALLS E, VANDERGIESSEN WJ, SERRUYS PW, ROELANDT J ( 1991 ) . THE EFFECT OF MILRINONE ON DIASTOLIC FUNCTION - DIRECT OR INDIRECT EFFECT . ACUTE THERAPY OF HEART FAILURE . vol. 2 , 35 - 42 .

Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R, Yin FC ( 1990 ) . Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum . American Journal of Physiology vol. 259 , ( 6 ) h1869 - h1880 .

Westerhof N, Sipkema P, Krams R ( 1990 ) . Myocardial modulation of coronary circulation Reply) . American Journal of Physiology - Heart and Circulatory Physiology vol. 259 , ( 6 28-6 )

Krams R, Sipkema P, Westerhof N ( 1990 ) . Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure . American Journal of Physiology vol. 258 , ( 6 ) h1889 - h1898 .

KRAMS R, SIPKEMA P, WESTERHOF N ( 1990 ) . CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE . AMERICAN JOURNAL OF PHYSIOLOGY vol. 258 , ( 6 ) H1889 - H1898 .

Krams R, Sipkema P, Westerhof N ( 1990 ) . Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure . American Journal of Physiology - Heart and Circulatory Physiology vol. 258 , ( 6 27-6 )

RESAR J, LIVINGSTON JZ, HALPERIN HR, SIPKEMA P, KRAMS R, YIN FCP ( 1990 ) . EFFECT OF WALL STRETCH ON CORONARY HEMODYNAMICS IN ISOLATED CANINE INTERVENTRICULAR SEPTUM . AMERICAN JOURNAL OF PHYSIOLOGY vol. 259 , ( 6 ) H1869 - H1880 .

Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R, Yin FCP ( 1990 ) . Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum . American Journal of Physiology - Heart and Circulatory Physiology vol. 259 , ( 6 28-6 )

WESTERHOF N, SIPKEMA P, KRAMS R ( 1990 ) . MYOCARDIAL MODULATION OF CORONARY CIRCULATION - REPLY . AMERICAN JOURNAL OF PHYSIOLOGY vol. 259 , ( 6 ) H1936 - H1937 .

Krams R, Sipkema P, Zegers J, Westerhof N ( 1989 ) . Contractility is the main determinant of coronary systolic flow impediment . American Journal of Physiology - Heart and Circulatory Physiology vol. 257 , ( 6 )

Krams R, Sipkema P, Westerhof N ( 1989 ) . Varying elastance concept may explain coronary systolic flow impediment . American Journal of Physiology vol. 257 , ( 5 ) h1471 - h1479 .

Krams R, Sipkema P, Westerhof N ( 1989 ) . Varying elastance concept may explain coronary systolic flow impediment . Am J Physiol vol. 257 , ( 5 Pt 2 ) H1471 - H1479 .

Krams R, van Haelst ACTA, Sipkema P, Westerhof N ( 1989 ) . Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance? . Basic Research in Cardiology vol. 84 , ( 2 ) 149 - 159 .

Van Dijk LC, Krams R, Sipkema P, Westerhof N ( 1988 ) . Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion . American Journal of Physiology vol. 255 , ( 3 ) h476 - h482 .

Van Dijk LC, Krams R, Sipkema P, Westerhof N ( 1988 ) . Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion . American Journal of Physiology - Heart and Circulatory Physiology vol. 255 , ( 3 )

YIN F, SIPKEMA P, KRAMS R, STRUMPF R, RESAR J ( 1988 ) . EFFECTS OF STRETCH ON THE PRESSURE-FLOW RELATION OF THE ISOLATED ARRESTED DOG SEPTUM . FASEB JOURNAL . vol. 2 , A302 - A302 .

SIPKEMA P, KRAMS R, WESTERHOF N ( 1988 ) . SYSTOLIC CORONARY FLOW IMPEDIMENT EXPLAINED ON BASIS OF THE TIME-VARYING ELASTANCE CONCEPT . FASEB JOURNAL . vol. 2 , A929 - A929 .

Westerhof N, Krams R ( 1986 ) . Comments on "Pressure and tone dependence of coronary diastolic input impedance and capacitance" . American Journal of Physiology vol. 250 , ( 2 ) h330 - h331 .

Westerhof N, Krams R ( 1986 ) . Comments on "Pressure and tone dependence of coronary diastolic input impedance and capacitance" . Am J Physiol vol. 250 , ( 2 Pt 2 ) H330 - H331 .

Westerhof N, Krams R, Canty JM ( 1986 ) . Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance' . American Journal of Physiology - Heart and Circulatory Physiology vol. 250 , ( 2 (19/2) )

KRAMS R, SIPKEMA P, WESTERHOF N ( 1985 ) . DOES LEFT-VENTRICULAR PRESSURE INFLUENCE THE CORONARY PRESSURE-FLOW RELATION IN THE CAT . JOURNAL OF PHYSIOLOGY-LONDON . vol. 366 , P42 - P42 .

Sipkema P, Burattini R, van Haelst ACTA, Krams R, Westerhof N ( 1984 ) . EFFECTS OF CARDIAC CONTRACTION ON CORONARY FLOW . Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings .

Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P et al. ( 1984 ) . "Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog" . Circulation Research vol. 54 , ( 3 ) 348 - 348 .

Westerhof N, Krams R, Van Haelst ACTA, Sipkema P ( 1984 ) . Can left ventricular pressure explain coronary flow impediment? . Federation Proceedings . vol. 43 ,

BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P, WESTERHOF N ( 1982 ) . THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS . CIRCULATION RESEARCH vol. 51 , ( 6 ) 822 - 822 .