Publications:  Dr Peter McCormick

Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA et al.(2020). Modulation of dopamine D<inf>1</inf> receptors via histamine H<inf>3</inf> receptors is a novel therapeutic target for Huntington's disease. eLife vol. 9,

Contino M, McCormick PJ(2020). Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain. Frontiers in Pharmacology vol. 11,

Lewis R, Li J, McCormick PJ, L-H Huang C, Jeevaratnam K(2020). Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review. IJC Heart and Vasculature vol. 26,

Botta J, Appelhans J, McCormick PJ(2020). Continuing challenges in targeting oligomeric GPCR-based drugs. vol. 169, 213-245.

Bridge T, Shaikh SA, Thomas P, Botta J, McCormick PJ, Sachdeva A(2019). Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody–Antigen Binding on Live Cells. Angewandte Chemie - International Edition vol. 58, (50) 17986-17993.

Botta J, Bibic L, Killoran P, McCormick PJ, Howell LA(2019). Design and development of stapled transmembrane peptides that disrupt the activity of G-protein coupled receptor oligomers. J Biol Chem

Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L et al.(2019). Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer. Proceedings of the National Academy of Sciences of the United States of America vol. 116, (9) 3863-3872.

Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L et al.(2019). Erratum: Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer (Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (3863–3872) DOI: 10.1073/pnas.1815034116). Proceedings of the National Academy of Sciences of the United States of America vol. 116, (13)

Aringhieri S, Carli M, Kolachalam S, Verdesca V, Cini E, Rossi M, McCormick PJ, Corsini GU et al.(2018). Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences. Pharmacology and Therapeutics vol. 192, 20-41.

Navarro G, Cordomí A, Brugarolas M, Moreno E, Aguinaga D, Pérez-Benito L, Ferre S, Cortés A et al.(2018). Cross-communication between G<inf>i</inf> and G<inf>s</inf> in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain. BMC Biology vol. 16, (1)

García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI et al.(2017). A Positive Allosteric Modulator of the Serotonin 5-HT<inf>2C</inf> Receptor for Obesity. Journal of Medicinal Chemistry vol. 60, (23) 9575-9584.

Sauvageau E, McCormick PJ, Lefrancois S(2017). In vivo monitoring of the recruitment and activation of AP-1 by Arf1. Scientific Reports vol. 7, (1)

Fahradpour M, Keov P, Tognola C, Perez-Santamarina E, McCormick PJ, Ghassempour A, Gruber CW(2017). Cyclotides isolated from an ipecac root extract antagonize the corticotropin releasing factor type 1 receptor. Frontiers in Pharmacology vol. 8, (SEP)

Rodríguez-Ruiz M, Moreno E, Moreno-Delgado D, Navarro G, Mallol J, Cortés A, Lluís C, Canela EI et al.(2017). Heteroreceptor Complexes Formed by Dopamine D<inf>1</inf>, Histamine H<inf>3</inf>, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease. Molecular Neurobiology vol. 54, (6) 4537-4550.

Botta J, Cordomi A, Bondar A, Lazar J, Pardo L, McCormick PJ (2017). PROBING THE MOLECULAR MECHANISM BEHIND THE COGNITIVE IMPAIRMENT INDUCED BY THC. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. vol. 121, 11-12.

González-Vera JA, Medina RA, Martín-Fontecha M, Gonzalez A, De La Fuente T, Vázquez-Villa H, García-Cárceles J, Botta J et al.(2017). A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding. Scientific Reports vol. 7,

HOWELL LA, Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Resel E, Puente N et al.(2017). Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. Neuropsychopharmacology (Nature)

McCormick PJ, Botta J(2017). Heteromers form novel signaling complexes. Receptors, vol. 33,

Hoffmann HM, Crouzin N, Moreno E, Raivio N, Fuentes S, McCormick PJ, Ortiz J, Vignes M(2017). Long-lasting impairment of mGluR<inf>5</inf>-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration. International Journal of Neuropsychopharmacology vol. 20, (1) 72-82.

Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M et al.(2016). The insulin-like growth factor I receptor regulates glucose transport by astrocytes. GLIA vol. 64, (11) 1962-1971.

Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ et al.(2016). Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure. Journal of Medicinal Chemistry vol. 59, (15) 7152-7166.

Navarro G, Aguinaga D, Angelats E, Medrano M, Moreno E, Mallol J, Cortés A, Canela EI et al.(2016). A significant role of the truncated ghrelin receptor GHS-R1b in ghrelin-induced signaling in neurons. Journal of Biological Chemistry vol. 291, (25) 13048-13062.

Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A et al.(2016). Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G<inf>i</inf> and G<inf>s</inf>. BMC Biology vol. 14, (1)

Scarselli M, Annibale P, McCormick PJ, Kolachalam S, Aringhieri S, Radenovic A, Corsini GU, Maggio R(2016). Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: Methods, dynamics and biological function. FEBS Journal vol. 283, (7) 1197-1217.

Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM et al.(2016). Adenosine deaminase regulates T<inf>reg</inf> expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1. Journal of Leukocyte Biology vol. 99, (2) 349-359.

Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S et al.(2015). Role of cannabinoid receptor CB<inf>2</inf> in HER2 pro-oncogenic signaling in breast cancer. Journal of the National Cancer Institute vol. 107, (6)

Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, De La Torre R, Gasperini P, Navarro G et al.(2015). Cognitive impairment induced by delta9- tetrahydrocannabinol occurs through heteromers between cannabinoid CB<inf>1</inf> and serotonin 5-HT<inf>2A</inf> receptors. PLoS Biology vol. 13, (7)

Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT et al.(2015). Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. PLoS Genetics vol. 11, (8)

Navarro G, Quiroz C, Moreno-Delgado D, Sierakowiak A, McDowell K, Moreno E, Rea W, Cai NS et al.(2015). Orexin–corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Journal of Neuroscience vol. 35, (17) 6639-6653.

Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy PP, Cortés A, Mallol J, Casadó V et al.(2014). Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers. Chemistry and Biology vol. 21, (11) 1546-1556.

Guitart X, Navarro G, Moreno E, Yano H, Cai NS, Sánchez-Soto M, Kumar-Barodia S, Naidu YT et al.(2014). Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: The dopamine D<inf>1</inf>-D<inf>3</inf>receptor heterotetramer. Molecular Pharmacology vol. 86, (4) 417-429.

Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR et al.(2014). Targeting CB<inf>2</inf>-GPR55 receptor heteromers modulates cancer cell signaling. Journal of Biological Chemistry vol. 289, (32) 21960-21972.

Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ et al.(2014). Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas. PLoS ONE vol. 9, (7)

Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE et al.(2014). L-DOPA-treatment in primates disrupts the expression of A<inf>2A</inf> adenosine-CB<inf>1</inf> cannabinoid-D<inf>2</inf> dopamine receptor heteromers in the caudate nucleus. Neuropharmacology vol. 79, 90-100.

Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodríguez-Ruiz M et al.(2014). Cocaine disrupts histamine H<inf>3</inf> receptor modulation of dopamine D<inf>1</inf> receptor signaling: σ<inf>1</inf>-D<inf>1</inf>-H<inf>3</inf> receptor complexes as key targets for reducing cocaine's effects. Journal of Neuroscience vol. 34, (10) 3545-3558.

Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G et al.(2014). L-DOPA disrupts adenosine A<inf>2A</inf>-cannabinoid CB<inf>1</inf>-dopamine D<inf>2</inf> receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies. Experimental Neurology vol. 253, 180-191.

Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C et al.(2013). A<inf>1</inf>R-A<inf>2A</inf>R heteromers coupled to G<inf>s</inf> and G<inf>i/0</inf> proteins modulate GABA transport into astrocytes. Purinergic Signalling vol. 9, (3) 433-449.

Gracia E, Moreno E, Cortés A, Lluís C, Mallol J, McCormick PJ, Canela EI, Casadó V(2013). Homodimerization of adenosine A<inf>1</inf> receptors in brain cortex explains the biphasic effects of caffeine. Neuropharmacology vol. 71, 56-69.

Navarro G, Moreno E, Bonaventura J, Brugarolas M, Farré D, Aguinaga D, Mallol J, Cortés A et al.(2013). Cocaine Inhibits Dopamine D<inf>2</inf> Receptor Signaling via Sigma-1-D<inf>2</inf> Receptor Heteromers. PLoS ONE vol. 8, (4)

Gracia E, Farré D, Cortés A, Ferrer-Costa C, Orozco M, Mallol J, Lluís C, Canela EI et al.(2013). The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors. FASEB Journal vol. 27, (3) 1048-1061.

Franco R, Martínez-Pinilla E, Ricobaraza A, McCormick PJ(2013). Challenges in the development of heteromer-GPCR-based drugs. Progress in Molecular Biology and Translational Science, vol. 117,

Navarro G, McCormick PJ, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI et al.(2013). Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology. Methods in Molecular Biology vol. 964, 95-105.

Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez-García M, Blanco J, Gatell JM, García F, Gallart T et al.(2012). Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals. PLoS ONE vol. 7, (12)

Luquin N, Sierra S, Rico AJ, Gómez-Bautista V, Roda E, Conte-Perales L, Franco R, McCormick P et al.(2012). Unmasking adenosine 2A receptors (A<inf>2A</inf>Rs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB). Neurobiology of Disease vol. 47, (3) 347-357.

Callén L, Moreno E, Barroso-Chinea P, Moreno-Delgado D, Cortés A, Mallol J, Casadó V, Lanciego JL et al.(2012). Cannabinoid receptors CB <inf>1</inf> and CB <inf>2</inf> form functional heteromers in brain. Journal of Biological Chemistry vol. 287, (25) 20851-20865.

González S, Rangel-Barajas C, Peper M, Lorenzo R, Moreno E, Ciruela F, Borycz J, Ortiz J et al.(2012). Dopamine D <inf>4</inf> receptor, but not the ADHD-associated D <inf>4.7</inf> variant, forms functional heteromers with the dopamine D <inf>2S</inf> receptor in the brain. Molecular Psychiatry vol. 17, (6) 650-662.

Navarro G, Hradsky J, Lluís C, Casadó V, McCormick PJ, Kreutz MR, Mikhaylova M(2012). NCS-1 associates with adenosine A <inf>2A</inf> receptors and modulates receptor function. Frontiers in Molecular Neuroscience (APRIL)

Gasperini P, Espigol-Frigole G, McCormick PJ, Salvucci O, Maric D, Uldrick TS, Polizzotto MN, Yarchoan R et al.(2012). Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through notch-dependent signaling. Cancer Research vol. 72, (5) 1157-1169.

González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, Franco R, Mallol J, Cortés A, Casadó V et al.(2012). Circadian-related heteromerization of adrenergic and dopamine d<inf>4</inf> receptors modulates melatonin synthesis and release in the pineal gland. PLoS Biology vol. 10, (6)

Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C et al.(2011). Modulation of GABA transport by adenosine A <inf>1</inf>R-A <inf>2A</inf>R heteromers, which are coupled to both G <inf>s</inf>- and G <inf>i/o</inf>-Proteins. Journal of Neuroscience vol. 31, (44) 15629-15639.

Hradsky J, Raghuram V, Reddy PP, Navarro G, Hupe M, Casado V, McCormick PJ, Sharma Y et al.(2011). Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca ²⁺ sensor calneurons requires the TRC40/Asna1 protein chaperone. Journal of Biological Chemistry vol. 286, (42) 36762-36776.

Moreno E, Vaz SH, Cai NS, Ferrada C, Quiroz C, Barodia SK, Kabbani N, Canela EI et al.(2011). Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus. Journal of Neuroscience vol. 31, (20) 7412-7423.

Vendrell M, Molero A, González S, Pérez-Capote K, Lluis C, McCormick PJ, Franco R, Cortés A et al.(2011). Biotin ergopeptide probes for dopamine receptors. Journal of Medicinal Chemistry vol. 54, (4) 1080-1090.

Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M et al.(2011). Dopamine D<inf>1</inf>-histamine H<inf>3</inf> receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. Journal of Biological Chemistry vol. 286, (7) 5846-5854.

Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortésa A, Casadó V et al.(2010). Direct involvement of σ-1 receptors in the dopamine D<inf>1</inf> receptor-mediated effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America vol. 107, (43) 18676-18681.

De La Luz Sierra M, Sakakibara S, Gasperini P, Salvucci O, Jiang K, McCormick PJ, Segarra M, Stone J et al.(2010). The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1. Blood vol. 115, (19) 3970-3979.

McCormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G(2009). Impaired recruitment of GrK6 and β-arrestin2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. PLoS ONE vol. 4, (12)

McCormick PJ, Dumaresq-Doiron K, Pluviose AS, Pichette V, Tosato G, Lefrancois S(2008). Palmitoylation controls recycling in lysosomal sorting and trafficking. Traffic vol. 9, (11) 1984-1997.

Segarra M, Williams CK, De La Luz Sierra M, Bernardo M, McCormick PJ, Maric D, Regino C, Choyke P et al.(2008). DII4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth. Blood vol. 112, (5) 1904-1911.

Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB(2008). CD1a and MHC class I follow a similar endocytic recycling pathway. Traffic vol. 9, (9) 1446-1457.

Lefrançois S, McCormick PJ(2007). The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes. Traffic vol. 8, (10) 1440-1451.

Sierra MDLL, Gasperini P, McCormick PJ, Zhu J, Tosato G(2007). Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. Blood vol. 110, (7) 2276-2285.

Saurí A, McCormick PJ, Johnson AE, Mingarro I(2007). Sec61α and TRAM are Sequentially Adjacent to a Nascent Viral Membrane Protein during its ER Integration. Journal of Molecular Biology vol. 366, (2) 366-374.

Salvucci O, Sierra MDLL, Martina JA, McCormick PJ, Tosato G(2006). EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling. Blood vol. 108, (9) 2914-2922.

McCormick PJ, Martina JA, Bonifacino JS(2005). Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proceedings of the National Academy of Sciences of the United States of America vol. 102, (22) 7910-7915.

Woolhead CA, McCormick PJ, Johnson AE(2004). Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins. Cell vol. 116, (5) 725-736.

McCormick PJ, Miao Y, Shao Y, Lin J, Johnson AE(2003). Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins. Molecular Cell vol. 12, (2) 329-341.