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Publications:  Dr Diego Villar Lozano

Villar D, Frost S, Deloukas P, Tinker A(2020). The contribution of non-coding regulatory elements to cardiovascular disease. Open biology vol. 10, (7)
10.1098/rsob.200088
Berthelot C, Villar D, Odom DT, Flicek P (2019). The gene expression consequences of mammalian regulatory evolution. EUROPEAN JOURNAL OF HUMAN GENETICS. vol. 27, 767-767.
Berthelot C, Villar D, Horvath JE, Odom DT, Flicek P(2018). Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression. Nat Ecol Evol vol. 2, Article 1, 152-163.
10.1038/s41559-017-0377-2
Jasinska AJ, Zelaya I, Service SK, Peterson CB, Cantor RM, Choi OW, DeYoung J, Eskin E et al.(2017). Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet vol. 49, Article 12, 1714-1721.
10.1038/ng.3959
Naranjo JR, Zhang H, Villar D, Gonzalez P, Dopazo XM, Moron-Oset J, Higueras E, Oliveros JC et al.(2016). Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. J Clin Invest vol. 126, Article 2, 627-38.
10.1172/jci82670
Rudolph KL, Schmitt BM, Villar D, White RJ, Marioni JC, Kutter C, Odom DT(2016). Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States. PLoS Genet vol. 12, Article 5, e1006024-e1006024.
10.1371/journal.pgen.1006024
Rensch T, Villar D, Horvath J, Odom DT, Flicek P(2016). Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data. Genome Biol vol. 17, Article 1, 139-139.
10.1186/s13059-016-0996-y
Villar D, Odom DT(2016). Unwinding Limb Development. Cell vol. 167, Article 3, 598-600.
10.1016/j.cell.2016.10.007
Villar D, Berthelot C, Aldridge S, Rayner TF, Lukk M, Pignatelli M, Park TJ, Deaville R et al.(2015). Enhancer evolution across 20 mammalian species. Cell vol. 160, Article 3, 554-66.
10.1016/j.cell.2015.01.006
Villar D, Odom DT(2015). When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say?. Dev Cell vol. 35, Article 1, 3-4.
10.1016/j.devcel.2015.09.022
Villar D, Flicek P, Odom DT(2014). Evolution of transcription factor binding in metazoans - mechanisms and functional implications. Nat Rev Genet vol. 15, Article 4, 221-33.
10.1038/nrg3481
Gonzalez-Flores A, Aguilar-Quesada R, Siles E, Pozo S, Rodriguez-Lara MI, Lopez-Jimenez L, Lopez-Rodriguez M, Peralta-Leal A et al.(2014). Interaction between PARP-1 and HIF-2alpha in the hypoxic response. Oncogene vol. 33, Article 7, 891-8.
10.1038/onc.2013.9
Tiana M, Villar D, Perez-Guijarro E, Gomez-Maldonado L, Molto E, Fernandez-Minan A, Gomez-Skarmeta JL, Montoliu L et al.(2012). A role for insulator elements in the regulation of gene expression response to hypoxia. Nucleic Acids Res vol. 40, Article 5, 1916-27.
10.1093/nar/gkr842
Villar D, Ortiz-Barahona A, Gomez-Maldonado L, Pescador N, Sanchez-Cabo F, Hackl H, Rodriguez BA, Trajanoski Z et al.(2012). Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions. PLoS One vol. 7, Article 9, e45708-e45708.
10.1371/journal.pone.0045708
Villar D, Odom DT(2012). Generalizing complexity: a fruitful partnership of functional genomics and systems biology. Genome Med vol. 4, Article 2, 11-11.
10.1186/gm310
Rivas M, Villar D, Gonzalez P, Dopazo XM, Mellstrom B, Naranjo JR(2011). Building the DREAM interactome. Sci China Life Sci vol. 54, Article 8, 786-92.
10.1007/s11427-011-4196-4
Ortiz-Barahona A, Villar D, Pescador N, Amigo J, del Peso L(2010). Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction. Nucleic Acids Res vol. 38, Article 7, 2332-45.
10.1093/nar/gkp1205
Pescador N, Villar D, Cifuentes D, Garcia-Rocha M, Ortiz-Barahona A, Vazquez S, Ordonez A, Cuevas Y et al.(2010). Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. PLoS One vol. 5, Article 3, e9644-e9644.
10.1371/journal.pone.0009644
Villar D, Vara-Vega A, Landazuri MO, Del Peso L(2007). Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains. Biochem J vol. 408, Article 2, 231-40.
10.1042/bj20071052
Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landazuri MO, Del Peso L(2005). Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem J vol. 390, Article Pt 1, 189-97.
10.1042/bj20042121
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