Publications: Dr Diego Villar Lozano
Villar D, Frost S, Deloukas P, Tinker A(2020).
The contribution of non-coding regulatory elements to cardiovascular disease. Open biology
vol. 10,
(7)
Berthelot C, Villar D, Odom DT, Flicek P (2019).
The gene expression consequences of mammalian regulatory evolution. EUROPEAN JOURNAL OF HUMAN GENETICS.
vol. 27,
767-767.
Berthelot C, Villar D, Horvath JE, Odom DT, Flicek P(2018).
Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression. Nat Ecol Evol
vol. 2,
Article 1,
152-163.
Jasinska AJ, Zelaya I, Service SK, Peterson CB, Cantor RM, Choi OW, DeYoung J, Eskin E et al.(2017).
Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet
vol. 49,
Article 12,
1714-1721.
Naranjo JR, Zhang H, Villar D, Gonzalez P, Dopazo XM, Moron-Oset J, Higueras E, Oliveros JC et al.(2016).
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. J Clin Invest
vol. 126,
Article 2,
627-38.
Rudolph KL, Schmitt BM, Villar D, White RJ, Marioni JC, Kutter C, Odom DT(2016).
Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States. PLoS Genet
vol. 12,
Article 5,
e1006024-e1006024.
Rensch T, Villar D, Horvath J, Odom DT, Flicek P(2016).
Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data. Genome Biol
vol. 17,
Article 1,
139-139.
Villar D, Odom DT(2016).
Unwinding Limb Development. Cell
vol. 167,
Article 3,
598-600.
Villar D, Berthelot C, Aldridge S, Rayner TF, Lukk M, Pignatelli M, Park TJ, Deaville R et al.(2015).
Enhancer evolution across 20 mammalian species. Cell
vol. 160,
Article 3,
554-66.
Villar D, Odom DT(2015).
When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say?. Dev Cell
vol. 35,
Article 1,
3-4.
Villar D, Flicek P, Odom DT(2014).
Evolution of transcription factor binding in metazoans - mechanisms and functional implications. Nat Rev Genet
vol. 15,
Article 4,
221-33.
Gonzalez-Flores A, Aguilar-Quesada R, Siles E, Pozo S, Rodriguez-Lara MI, Lopez-Jimenez L, Lopez-Rodriguez M, Peralta-Leal A et al.(2014).
Interaction between PARP-1 and HIF-2alpha in the hypoxic response. Oncogene
vol. 33,
Article 7,
891-8.
Tiana M, Villar D, Perez-Guijarro E, Gomez-Maldonado L, Molto E, Fernandez-Minan A, Gomez-Skarmeta JL, Montoliu L et al.(2012).
A role for insulator elements in the regulation of gene expression response to hypoxia. Nucleic Acids Res
vol. 40,
Article 5,
1916-27.
Villar D, Ortiz-Barahona A, Gomez-Maldonado L, Pescador N, Sanchez-Cabo F, Hackl H, Rodriguez BA, Trajanoski Z et al.(2012).
Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions. PLoS One
vol. 7,
Article 9,
e45708-e45708.
Villar D, Odom DT(2012).
Generalizing complexity: a fruitful partnership of functional genomics and systems biology. Genome Med
vol. 4,
Article 2,
11-11.
Rivas M, Villar D, Gonzalez P, Dopazo XM, Mellstrom B, Naranjo JR(2011).
Building the DREAM interactome. Sci China Life Sci
vol. 54,
Article 8,
786-92.
Ortiz-Barahona A, Villar D, Pescador N, Amigo J, del Peso L(2010).
Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction. Nucleic Acids Res
vol. 38,
Article 7,
2332-45.
Pescador N, Villar D, Cifuentes D, Garcia-Rocha M, Ortiz-Barahona A, Vazquez S, Ordonez A, Cuevas Y et al.(2010).
Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. PLoS One
vol. 5,
Article 3,
e9644-e9644.
Villar D, Vara-Vega A, Landazuri MO, Del Peso L(2007).
Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains. Biochem J
vol. 408,
Article 2,
231-40.
Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landazuri MO, Del Peso L(2005).
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem J
vol. 390,
Article Pt 1,
189-97.