Publications: Dr James Ruffle

Topan R, Pandya S, Williams S, Ruffle JK, Zarate-Lopez N, Aziz Q, Fikree A ( 2024 ) . Comprehensive Assessment of Nutrition and Dietary Influences in Hypermobile Ehlers-Danlos Syndrome-A Cross-sectional Study . The American Journal of Gastroenterology

Giles D, Gray R, Foulon C, Pombo G, Xu T, Ruffle JK, Jäger HR, Cardoso J et al. ( 2023 ) . InterSynth: A Semi-Synthetic Framework for Benchmarking Prescriptive Inference from Observational Data . Machine Learning for Multimodal Healthcare Data , vol. 14315 , Springer Nature

Lee F, Ruffle J, Mohinta S, Kopanitsa V, Nachev P, Hyare H ( 2023 ) . AUTOMATED VASARI FEATURE SET REPORTING FOR GLIOMAS IS EffCIENT AND EFFECTIVE . Neuro-Oncology vol. 25 , ( Supplement_3 ) iii18 - iii19 .

Ruffle J, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al. ( 2023 ) . BRAIN TUMOUR GENETIC NETWORK SIGNATURES SUPERIORLY FORECAST SURVIVAL . Neuro-Oncology vol. 25 , ( Supplement_3 ) iii3 - iii3 .

Ruffle J, Mohinta S, Brandner S, Hyare H, Nachev P ( 2023 ) . DEMOGRAPHICS, GENETICS, AND EPIGENETICS INflUENCE THE LESION DISTRIBUTION OF GLIOMA . Neuro-Oncology vol. 25 , ( Supplement_3 ) iii4 - iii4 .

Tan L, Ruffle J, Rees J, Kosmin M, Nachev P, Hyare H ( 2023 ) . MATHEMATICAL MODELLING OF SURVIVAL IN LOW GRADE GLIOMAS AT MALIGNANT TRANSFORMATION . Neuro-Oncology vol. 25 , ( Supplement_3 ) iii19 - iii19 .

Ruffle JK, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al. ( 2023 ) . Brain tumour genetic network signatures of survival . Brain vol. 146 , ( 11 ) 4736 - 4754 .

Ruffle JK, Foulon C, Nachev P ( 2023 ) . The human cost of ethical artificial intelligence . Brain Structure and Function vol. 228 , ( 6 ) 1365 - 1369 .

Ruffle JK, Mohinta S, Gray R, Hyare H, Nachev P ( 2023 ) . Brain tumour segmentation with incomplete imaging data . Brain Communications vol. 5 , ( 2 )

Elmalem MS, Moody H, Ruffle JK, de Schotten MT, Haggard P, Diehl B, Nachev P, Jha A ( 2023 ) . A framework for focal and connectomic mapping of transiently disrupted brain function . Communications Biology vol. 6 , ( 1 )

Choudhary A, Fikree A, Ruffle J, Takahashi K, Palsson OS, Aziz I, Aziz Q ( 2023 ) . Disorders of gut-brain interaction in patients with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorders: Characterisation of co-morbidities and quality of life . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 35 ,

Topan R, Pandya S, Williams S, Ruffle J, Zarate-Lopez N, Aziz Q, Fikree A ( 2023 ) . Positive screen for Avoidant-Restrictive Food Intake Disorder (ARFID) increases odds of artificial nutrition by four-fold in Hypermobile Ehlers-Danlos Syndrome (hEDS) . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 35 ,

Cipolotti L, Ruffle JK, Mole J, Xu T, Hyare H, Shallice T, Chan E, Nachev P ( 2022 ) . Graph lesion-deficit mapping of fluid intelligence . Brain vol. 146 , ( 1 ) 167 - 181 .

Lim EA, Ruffle JK, Gnanadurai R, Lee H, Escobedo-Cousin M, Wall E, Cwynarski K, Heyderman RS et al. ( 2022 ) . Author Correction: Differentiating central nervous system infection from disease infiltration in hematological malignancy . Scientific Reports vol. 12 , ( 1 )

Ruffle J, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al. ( 2022 ) . CNSC-26. NETWORK SIGNATURES OF SURVIVAL IN BRAIN TUMOUR GENETICS . Neuro-Oncology vol. 24 , ( Supplement_7 ) vii27 - vii28 .

Ruffle J, Mohinta S, Brandner S, Hyare H, Nachev P ( 2022 ) . NIMG-35. THE DEEP TOPOLOGY OF GLIOMAS . Neuro-Oncology vol. 24 , ( Supplement_7 ) vii171 - vii171 .

Carruthers R, Straw I, Ruffle JK, Herron D, Nelson A, Bzdok D, Fernandez-Reyes D, Rees G et al. ( 2022 ) . Representational ethical model calibration . npj Digital Medicine vol. 5 , ( 1 )

Rajiah R, Takahashi K, Aziz Q, Ruffle JK ( 2022 ) . Brain effect of transcutaneous vagal nerve stimulation: A meta‐analysis of neuroimaging evidence . Neurogastroenterology & Motility

Ruffle J, Mohinta S, Gray R, Hyare H, Nachev P ( 2022 ) . Deep Learning for Tumour Segmentation with Missing Data . Neuro-Oncology vol. 24 , ( Supplement_4 ) iv16 - iv16 .

Ruffle J, Mohinta S, Gray R, Hyare H, Nachev P ( 2022 ) . Identifying Enhancing Tumour Without Contrast-Enhanced Imaging . Neuro-Oncology vol. 24 , ( Supplement_4 ) iv3 - iv3 .

Lim EA, Ruffle JK, Gnanadurai R, Lee H, Escobedo-Cousin M, Wall E, Cwynarski K, Heyderman RS et al. ( 2022 ) . Differentiating central nervous system infection from disease infiltration in hematological malignancy . Scientific Reports vol. 12 , ( 1 )

Topan R, Williams S, Pandya S, Ruffle JK, Zarate-Lopez N, Aziz Q, Fikree A ( 2022 ) . O57 Artificial nutrition use in hypermobile ehlers danlos syndrome: common with autonomic symptoms and disordered eating . Conference: Oral presentationsa32.2 - a3a33 .

Topan R, Pandya S, Williams S, Ruffle JK, Zarate-Lopez N, Aziz Q, Fikree A ( 2022 ) . P297 Altered diet in hypermobile ehlers danlos syndromeis predicted by upper gastrointestinal disorders and psychopathology . Conference: Poster presentationsa184.1 - a1a184 .

Takahashi K, Ruffle JK, Terai S, Satti H, Aziz Q ( 2022 ) . 537: CAN ARTIFICIAL INTELLIGENCE PREDICT THE DEVELOPMENT OF ABDOMINAL PAIN IN CHILDREN? . Gastroenterology vol. 162 , ( 7 ) s - 125 .

Nelson APK, Gray RJ, Ruffle JK, Watkins HC, Herron D, Sorros N, Mikhailov D, Cardoso MJ et al. ( 2022 ) . Deep forecasting of translational impact in medical research . Patterns vol. 3 , ( 5 )

Takahashi K, Ruffle JK, Terai S, Satti H, Aziz Q ( 2022 ) . CAN ARTIFICIAL INTELLIGENCE PREDICT THE DEVELOPMENT OF ABDOMINAL PAIN IN CHILDREN? . GASTROENTEROLOGY . vol. 162 , S125 - S125 .

Ruffle J, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H et al. ( 2022 ) . NETWORK SIGNATURES OF SURVIVAL IN BRAIN TUMOUR GENETICS . NEURO-ONCOLOGY . vol. 24 , 27 - 28 .

Ruffle J, Mohinta S, Brandner S, Hyare H, Nachev P ( 2022 ) . THE DEEP TOPOLOGY OF GLIOMAS . NEURO-ONCOLOGY . vol. 24 , 171 - 171 .

Ruffle JK, Hyare H, Howard MA, Farmer AD, Apkarian AV, Williams SCR, Aziz Q, Nachev P ( 2021 ) . The autonomic brain: multi-dimensional generative hierarchical modelling of the autonomic connectome . Cortex

Lim EA, Gnanadurai R, Ruffle JK, Lee H, Miller RF, Hyare H ( 2021 ) . Neuroimaging of CNS infection in haematological malignancy: important signs and common diagnostic pitfalls . Clinical Radiology vol. 76 , ( 6 ) 470.e1 - 470.e12 .

Ruffle J, Tinkler L, Emmett C, Ford A, Nachev P, Aziz Q, Farmer A, Yiannakou Y ( 2021 ) . P342 Constipation-predominant irritable bowel syndrome and functional constipation are not discrete disorders: a machine learning approach . Conference: Postersa218 - a218 .

Rajiah R, Henderson M, Aziz Q, Yiannakou Y, Ruffle J ( 2021 ) . Network modelling in chronic constipation . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,

Rajiah R, Takahashi K, Aziz Q, Ruffle J ( 2021 ) . Transcutaneous vagal nerve stimulation as a potential treatment in functional gastrointestinal disorders: A meta-analysis of neuroimaging evidence . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,

Colecchia F, Ruffle JK, Pombo GC, Gray R, Hyare H, Nachev P ( 2020 ) . Knowledge-driven deep neural network models for brain tumour segmentation . Journal of Physics Conference Series . vol. 1662 ,

Ruffle JK, Tinkler L, Emmett C, Ford AC, Nachev P, Aziz Q, Farmer AD, Yiannakou Y ( 2020 ) . Constipation Predominant Irritable Bowel Syndrome and Functional Constipation Are Not Discrete Disorders: A Machine Learning Approach . The American Journal of Gastroenterology vol. 116 , ( 1 ) 142 - 151 .

Albu-Soda A, Aziz Q, FARMER A ( 2020 ) . Transcutaneous vagus nerve stimulation prevents the development of, and reverses, established oesophageal pain hypersensitivity . Alimentary Pharmacology and Therapeutics

Farmer AD, Wood E, Ruffle JK ( 2020 ) . An approach to the care of patients with irritable bowel syndrome . Canadian Medical Association Journal vol. 192 , ( 11 ) e275 - e282 .

Ruffle JK, Farmer AD, Aziz Q ( 2020 ) . Chapter 33 Artificial intelligence in gastroenterology . Precision Medicine for Investigators, Practitioners and Providers , Elsevier

Kanber B, Ruffle J, Cardoso J, Ourselin S, Ciccarelli O ( 2019 ) . Neurosense: deep sensing of full or near-full coverage head/brain scans in human magnetic resonance imaging . Neuroinformatics vol. 18 , ( 2 ) 333 - 336 .

Farmer AD, Ruffle JK ( 2019 ) . Irritable bowel syndrome . Medicine vol. 47 , ( 6 ) 350 - 353 .

Ruffle J, Tinkler L, Emmett C, Aziz Q, Farmer A, Yiannakou Y ( 2019 ) . OWE-14 Symptom burden in chronic constipation is predicted by sensory domains, not stool frequency . Gut . Conference: Neurogastroenterology vol. 68 ,

Ruffle J, Tinkler L, Emmett C, Aziz Q, Farmer A, Yiannakou Y ( 2019 ) . PWE-097 Machine learning can accurately classify chronic constipation patients by symptom burden using pain measures alone . Gut . Conference: Posters vol. 68 ,

Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y ( 2019 ) . Su1630 – Sensory Domains, Not Stool Frequency, Predict a Higher Symptom Burden and a Reduction in Quality of Life in Chronic Constipation . Gastroenterology vol. 156 , ( 6 ) s - 590 .

Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y ( 2019 ) . Su1631 – Machine Learning with Pain Measures Alone Can Accurately Classify Chronic Constipation Patients to High Or Low Total Symptom Burden . Gastroenterology vol. 156 , ( 6 )

Ruffle JK, Patel A, Giampietro V, Howard MA, Sanger GJ, Andrews PLR, Williams SCR, Aziz Q et al. ( 2019 ) . Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning . The Journal of Physiology vol. 597 , ( 6 ) 1517 - 1529 .

Ruffle JK, Farmer AD, Aziz Q ( 2019 ) . Artificial intelligence in gastroenterology . Precision Medicine for Investigators, Practitioners and Providers ,

Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y ( 2019 ) . MACHINE LEARNING WITH PAIN MEASURES ALONE CAN ACCURATELY CLASSIFY CHRONIC CONSTIPATION PATIENTS TO HIGH OR LOW TOTAL SYMPTOM BURDEN . GASTROENTEROLOGY . vol. 156 , S590 - S591 .

Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y ( 2019 ) . SENSORY DOMAINS, NOT STOOL FREQUENCY, PREDICT A HIGHER SYMPTOM BURDEN AND A REDUCTION IN QUALITY OF LIFE IN CHRONIC CONSTIPATION . GASTROENTEROLOGY . vol. 156 , S590 - S590 .

Farmer AD, Ruffle JK, Hobson AR ( 2018 ) . Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation . Neurogastroenterology & Motility vol. 31 , ( 2 )

Farmer AD, Ruffle JK, Barber M ( 2018 ) . Moving Neurogastroenterology and Motility into the social media age . Neurogastroenterology & Motility vol. 30 , ( 11 )

Ruffle JK, FARMER A, AZIZ Q ( 2018 ) . Artificial Intelligence Assisted Gastroenterology – Promises and Pitfalls . American Journal of Gastroenterology

Ruffle JK, AZIZ Q ( 2018 ) . Abdominal pain presenting as a tight squeeze on a Tchaikovsky score . Gastroenterology

Albusoda A, Ruffle JK, Friis KA, Gysan MR, Drewes AM, Aziz Q, Farmer AD ( 2018 ) . Systematic review with meta‐analysis: conditioned pain modulation in patients with the irritable bowel syndrome . Alimentary Pharmacology & Therapeutics vol. 48 , ( 8 ) 797 - 806 .

Ruffle JK, AZIZ Q, FARMER A, COEN S, Giampietro V, Williams SCR ( 2018 ) . Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain . Scientific Reports vol. 8 , Article 13410 ,

Albusoda A, Friss K, Gysan M, Ruffle J, Aziz Q, Farmer A ( 2018 ) . OWE-026 Conditioned pain modulation in functional gastrointestinal disorders: systematic review & meta-analysis . Conference: Neurogastroenterology & motilitya207 - a207 .

Patel A, Ruffle J, Giampietro V, Aziz Q, Farmer A ( 2018 ) . PWE-144 Susceptibility to nausea is concurrently associated with subcortical morphology and autonomic tone . Gut . Conference: Neurogastroenterology & motility vol. 67 ,

Ruffle J, Coen S, Giampietro V, Williams S, Aziz Q, Farmer A ( 2018 ) . PWE-146 Pain endophenotypes display complex subcortical brain morphological differences influenced by autonomic neurophysiology or personality traits . Gut . Conference: Neurogastroenterology & motility vol. 67 ,

Ruffle JK, Coen SJ, Giampietro V, Williams SC, Aziz Q, Farmer AD ( 2018 ) . 745 - Visceral Pain Endophenotypes Associate to Intricate Subcortical Brain Morphological Differences Contingent on Differing Autonomic Physiology or Personality . Gastroenterology vol. 154 , ( 6 )

Ruffle JK, Aziz Q, Farmer AD ( 2018 ) . Pronociceptive effects mediated by adenosinergic A2A activity at the nucleus accumbens, but what about the autonomic nervous system? . Pain vol. 159 , ( 5 )

Keszthelyi D, Aziz Q, Ruffle JK, O'Daly O, Sanders D, Krause K, Williams SCR, Howard MA ( 2018 ) . Delineation between different components of chronic pain using dimension reduction – an ASL fMRI study in hand osteoarthritis . European Journal of Pain vol. 22 , ( 7 ) 1245 - 1254 .

Ruffle J, Patel A, Giampietro V, Aziz Q, Farmer A ( 2018 ) . A thalamic-cingulate-caudate functional network identifies nausea severity and predicts susceptibility using machine learning . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,

Farmer AD, Ruffle JK, Aziz Q ( 2018 ) . Brain Processing of Gastrointestinal Sensory Signaling . Physiology of the Gastrointestinal Tract, Sixth Edition , vol. 1 ,

Farmer AD, Ruffle JK, Aziz Q ( 2018 ) . Chapter 16 Brain Processing of Gastrointestinal Sensory Signaling . Physiology of the Gastrointestinal Tract , Elsevier

Patel A, Ruffle J, Giampietro V, Aziz Q, Farmer A ( 2018 ) . Nausea susceptibility is associated with subcortical brain morphology . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,

Farmer A, Ruffle J, Holt CB ( 2018 ) . Real world experience of naloxegol in treating opioid induced constipation . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 30 ,

Ruffle JK, Coen SJ, Giampietro V, Williams SC, Aziz Q, Farmer AD ( 2018 ) . VISCERAL PAIN ENDOPHENOTYPES ASSOCIATE TO INTRICATE SUBCORTICAL BRAIN MORPHOLOGICAL DIFFERENCES CONTINGENT ON DIFFERING AUTONOMIC PHYSIOLOGY OR PERSONALITY . GASTROENTEROLOGY . vol. 154 , S155 - S156 .

Mudawi T, Mahto A, Ruffle JK, Bubbear J ( 2017 ) . 23. Multi-site avascular necrosis of idiopathic aetiology . Rheumatology Advances in Practice vol. 1 , ( suppl_1 )

Ruffle J, Farmer A, Aziz Q ( 2017 ) . Morphology of Subcortical Brain Nuclei Is Associated With Autonomic Function in Healthy Humans . Human Brain Mapping

Ruffle JK, Aziz Q, Farmer AD ( 2017 ) . Neuroimaging of vagal nerve stimulation . Pain vol. 158 , ( 10 )

Ruffle J, Coen S, Giampietro V, Williams S, Farmer A, Aziz Q ( 2017 ) . OC-054 Pain endophenotypes can be accurately predicted by whole brain connectivity during painful oesophageal stimulation . Gut . vol. 66 ,

Ruffle J, Coen S, Giampietro V, Williams S, Farmer A, Aziz Q ( 2017 ) . PTH-117 Subcortical brain morphology differences in gastrointestinal disorders may be confounded by baseine autonomic function . Gut . vol. 66 ,

Ruffle JK, Frokjaer JB, Farmer AD ( 2017 ) . Neuroimaging of Visceral Pain . Neuroimaging of Pain , Springer Nature

Farmer A, Ruffle J ( 2017 ) . Irritable bowel syndrome: enigmatic for doctors, problematic for patients . Trends in Urology & Men's Health vol. 8 , ( 2 ) 13 - 16 .

Albusoda A, Ruffle JK, Drewes A, Farmer AD, Aziz Q ( 2017 ) . 367 Effect of Slow Deep Breathing and Attention on the Autonomic Nervous System . Gastroenterology . vol. 152 , s88 - s89 .

Ruffle JK, Coen SJ, Giampietro V, Williams SC, Farmer AD, Aziz Q ( 2017 ) . Tu1621 Brain Morphological Differences in Gastrointestinal Disorders May Be in Part Due to Alteration in Resting Autonomic Function . Gastroenterology . vol. 152 , s918 - s919 .

Farmer AD, Ruffle JK, Aziz Q ( 2017 ) . The Role of Esophageal Hypersensitivity in Functional Esophageal Disorders . Journal of Clinical Gastroenterology vol. 51 , ( 2 ) 91 - 99 .

Albusoda A, Ruffle J, Drewes A, Farmer A, Aziz Q ( 2017 ) . Autonomic modulation via slow deep breathing and attention . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 47 , 123 - 123 .

Hoff DAL, Brock C, Farmer AD, Dickman R, Ruffle JK, Shaker A, Drewes AM ( 2016 ) . Pharmacological and other treatment modalities for esophageal pain . Annals of the New York Academy of Sciences vol. 1380 , ( 1 ) 58 - 66 .

Ruffle JK, Bajgoric S, Samra K, Chandrapalan S, Aziz Q, Farmer AD ( 2015 ) . Cannabinoid hyperemesis syndrome . European Journal of Gastroenterology & Hepatology vol. 27 , ( 12 ) 1403 - 1408 .

Ruffle JK, Shah M, Monro J, Julu POO ( 2015 ) . Pattern Of Dysautonomia In Patients With Functional Gastrointestinal Disorders . Autonomic Neuroscience vol. 192 ,

Ruffle JK, Farmer AD, Kano M, Giampietro V, Aziz Q, Coen SJ ( 2014 ) . The influence of extraversion on brain activity at baseline and during the experience and expectation of visceral pain . PERSONALITY AND INDIVIDUAL DIFFERENCES vol. 74 , 248 - 253 .

Ruffle JK ( 2014 ) . Molecular neurobiology of addiction: what’s all the (Δ)FosB about? . The American Journal of Drug and Alcohol Abuse vol. 40 , ( 6 ) 428 - 437 .

Ruffle J, Coen S, Farmer A, Kano M, Giampietro V, Williams S, Aziz Q ( 2014 ) . OC-066 Influence Of Extraversion On Brain Activity At Baseline, Pain Anticipation And Visceral Pain Processing . Gut vol. 63 , ( Suppl 1 )

Ruffle JK, Coen SJ, Farmer AD, Kano M, Gampietro V, Williams S, Aziz Q ( 2014 ) . Tu1803 Influence of Extraversion on Brain Activity During Rest, Pain Anticipation and Visceral Pain Processing . Gastroenterology vol. 146 , ( 5 ) s - 847 .

Ruffle JK, Coen SJ, Farmer AD, Kano M, Gampietro V, Williams S, Aziz Q ( 2014 ) . Influence of Extraversion on Brain Activity During Rest, Pain Anticipation and Visceral Pain Processing . GASTROENTEROLOGY . vol. 146 , S847 - S847 .

Ng KS, Chua YC, Ban VF, Gresty M, Gampietro V, Coen SJ, Sanger GJ, Fitch KE et al. ( 2013 ) . Su2110 Brain Processing of Visual Motion Induced Nausea in Healthy Humans . Gastroenterology vol. 144 , ( 5 )

Ng KS, Chua YC, Ban VF, Gresty M, Coen SJ, Sanger GJ, Williams SC, Barker G et al. ( 2012 ) . 490 Studies of the Psychophysiological Markers and the Brain Processing of Nausea in Healthy Humans Using a Novel Virtual Reality Video . Gastroenterology vol. 142 , ( 5 ) s - 105 .