Publications:  Dr James Ruffle

Kanber B, Ruffle J, Cardoso J, Ourselin S, Ciccarelli O(2020). Neurosense: deep sensing of full or near-full coverage head/brain scans in human magnetic resonance imaging. Neuroinformatics vol. 18, (2) 333-336.

Farmer AD, Wood E, Ruffle JK(2020). An approach to the care of patients with irritable bowel syndrome. CMAJ vol. 192, (11) E275-E282.

Farmer AD, Ruffle JK(2019). Irritable bowel syndrome. Medicine (United Kingdom) vol. 47, (6) 350-353.

Ruffle J, Tinkler L, Emmett C, Aziz Q, Farmer A, Yiannakou Y (2019). MACHINE LEARNING CAN ACCURATELY CLASSIFY CHRONIC CONSTIPATION PATIENTS BY SYMPTOM BURDEN USING PAIN MEASURES ALONE. GUT. vol. 68, A218-A219.

Ruffle J, Tinkler L, Emmett C, Aziz Q, Farmer A, Yiannakou Y (2019). SYMPTOM BURDEN IN CHRONIC CONSTIPATION IS PREDICTED BY SENSORY DOMAINS, NOT STOOL FREQUENCY. GUT. vol. 68, A205-A205.

Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y (2019). MACHINE LEARNING WITH PAIN MEASURES ALONE CAN ACCURATELY CLASSIFY CHRONIC CONSTIPATION PATIENTS TO HIGH OR LOW TOTAL SYMPTOM BURDEN. GASTROENTEROLOGY. vol. 156, S590-S591.

Ruffle JK, Tinkler L, Emmett C, Aziz Q, Farmer AD, Yiannakou Y (2019). SENSORY DOMAINS, NOT STOOL FREQUENCY, PREDICT A HIGHER SYMPTOM BURDEN AND A REDUCTION IN QUALITY OF LIFE IN CHRONIC CONSTIPATION. GASTROENTEROLOGY. vol. 156, S590-S590.

Ruffle JK, Patel A, Giampietro V, Howard MA, Sanger GJ, Andrews PLR, Williams SCR, Aziz Q et al.(2019). Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning. Journal of Physiology vol. 597, (6) 1517-1529.

Farmer AD, Ruffle JK, Hobson AR(2019). Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation. Neurogastroenterology and Motility vol. 31, (2)

Farmer AD, Ruffle JK, Barber M(2018). Moving Neurogastroenterology and Motility into the social media age. Neurogastroenterology and Motility vol. 30, (11)

Ruffle JK, FARMER A, AZIZ Q(2018). Artificial Intelligence Assisted Gastroenterology – Promises and Pitfalls. American Journal of Gastroenterology

Albusoda A, Ruffle JK, Friis KA, Gysan MR, Drewes AM, Aziz Q, Farmer AD(2018). Systematic review with meta-analysis: conditioned pain modulation in patients with the irritable bowel syndrome. Alimentary Pharmacology and Therapeutics vol. 48, (8) 797-806.

Ruffle JK, AZIZ Q(2018). Abdominal pain presenting as a tight squeeze on a Tchaikovsky score. Gastroenterology

Ruffle JK, AZIZ Q, FARMER A, COEN S, Giampietro V, Williams SCR(2018). Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain. Scientific Reports vol. 8, Article 13410,

Ruffle J, Patel A, Giampietro V, Aziz Q, Farmer A (2018). A thalamic-cingulate-caudate functional network identifies nausea severity and predicts susceptibility using machine learning. NEUROGASTROENTEROLOGY AND MOTILITY. vol. 30,

Keszthelyi D, Aziz Q, Ruffle JK, O'Daly O, Sanders D, Krause K, Williams SCR, Howard MA(2018). Delineation between different components of chronic pain using dimension reduction – an ASL fMRI study in hand osteoarthritis. European Journal of Pain (United Kingdom) vol. 22, (7) 1245-1254.

Patel A, Ruffle J, Giampietro V, Aziz Q, Farmer A (2018). Nausea susceptibility is associated with subcortical brain morphology. NEUROGASTROENTEROLOGY AND MOTILITY. vol. 30,

Farmer A, Ruffle J, Holt CB (2018). Real world experience of naloxegol in treating opioid induced constipation. NEUROGASTROENTEROLOGY AND MOTILITY. vol. 30,

Albusoda A, Friss K, Gysan M, Ruffle J, Aziz Q, Farmer A (2018). CONDITIONED PAIN MODULATION IN FUNCTIONAL GASTROINTESTINAL DISORDERS: SYSTEMATIC REVIEW & META-ANALYSIS. GUT. vol. 67, A207-A207.

Ruffle J, Coen S, Giampietro V, Williams S, Aziz Q, Farmer A (2018). PAIN ENDOPHENOTYPES DISPLAY COMPLEX SUBCORTICAL BRAIN MORPHOLOGICAL DIFFERENCES INFLUENCED BY AUTONOMIC NEUROPHYSIOLOGY OR PERSONALITY TRAITS. GUT. vol. 67, A220-A221.

Patel A, Ruffle J, Giampietro V, Aziz Q, Farmer A (2018). SUSCEPTIBILITY TO NAUSEA IS CONCURRENTLY ASSOCIATED WITH SUBCORTICAL MORPHOLOGY AND AUTONOMIC TONE. GUT. vol. 67, A219-A220.

Ruffle JK, Aziz Q, Farmer AD(2018). Pronociceptive effects mediated by adenosinergic A2A activity at the nucleus accumbens, but what about the autonomic nervous system?. Pain vol. 159, (5)

Ruffle JK, Coen SJ, Giampietro V, Williams SC, Aziz Q, Farmer AD (2018). VISCERAL PAIN ENDOPHENOTYPES ASSOCIATE TO INTRICATE SUBCORTICAL BRAIN MORPHOLOGICAL DIFFERENCES CONTINGENT ON DIFFERING AUTONOMIC PHYSIOLOGY OR PERSONALITY. GASTROENTEROLOGY. vol. 154, S155-S156.

Farmer AD, Ruffle JK, Aziz Q(2018). Brain Processing of Gastrointestinal Sensory Signaling. Physiology of the Gastrointestinal Tract: Sixth Edition, vol. 1-2,

Ruffle J, Farmer A, Aziz Q(2017). Morphology of Subcortical Brain Nuclei Is Associated With Autonomic Function in Healthy Humans. Human Brain Mapping

Ruffle JK, Aziz Q, Farmer AD(2017). Neuroimaging of vagal nerve stimulation: are we missing a trick?. Pain vol. 158, (10)

Ruffle JK, Coen SJ, Giampietro V, Williams SCR, Farmer AD, Aziz Q (2017). PAIN ENDOPHENOTYPES CAN BE ACCURATELY PREDICTED BY WHOLE BRAIN CONNECTIVITY DURING PAINFUL OESOPHAGEAL STIMULATION. GUT. vol. 66, A28-A29.

Ruffle JK, Coen SJ, Giampietro V, Williams SCR, Farmer AD, Aziz Q (2017). SUBCORTICAL BRAIN MORPHOLOGY DIFFERENCES IN GASTROINTESTINAL DISORDERS MAY BE CONFOUNDED BY BASEINE AUTONOMIC FUNCTION. GUT. vol. 66, A264-A264.

Ruffle JK, Frokjaer JB, Farmer AD(2017). Neuroimaging of v1isceral pain. Neuroimaging of Pain,

Albusoda A, Ruffle J, Drewes A, Farmer A, Aziz Q (2017). Autonomic modulation via slow deep breathing and attention. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. vol. 47, 123-123.

Ruffle JK, Coen SJ, Giampietro V, Williams SC, Farmer AD, Aziz Q (2017). BRAIN MORPHOLOGICAL DIFFERENCES IN GASTROINTESTINAL DISORDERS MAY BE IN PART DUE TO ALTERATION IN RESTING AUTONOMIC FUNCTION. GASTROENTEROLOGY. vol. 152, S918-S919.

Albusoda A, Ruffle JK, Drewes A, Farmer AD, Aziz Q (2017). EFFECT OF SLOW DEEP BREATHING AND ATTENTION ON THE AUTONOMIC NERVOUS SYSTEM. GASTROENTEROLOGY. vol. 152, S88-S89.

Farmer AD, Ruffle JK, Aziz Q(2017). The role of esophageal hypersensitivity in functional esophageal disorders. Journal of Clinical Gastroenterology vol. 51, (2) 91-99.

Hoff DAL, Brock C, Farmer AD, Dickman R, Ruffle JK, Shaker A, Drewes AM(2016). Pharmacological and other treatment modalities for esophageal pain. Annals of the New York Academy of Sciences vol. 1380, (1) 58-66.

Ruffle JK, Bajgoric S, Samra K, Chandrapalan S, Aziz Q, Farmer AD(2015). Cannabinoid hyperemesis syndrome: An important differential diagnosis of persistent unexplained vomiting. European Journal of Gastroenterology and Hepatology vol. 27, (12) 1403-1408.

Ruffle JK, Farmer AD, Kano M, Giampietro V, Aziz Q, Coen SJ(2014). The influence of extraversion on brain activity at baseline and during the experience and expectation of visceral pain. PERSONALITY AND INDIVIDUAL DIFFERENCES vol. 74, 248-253.

Ruffle J, Coen S, Farmer A, Kano M, Giampietro V, Williams S, Aziz Q(2014). OC-066 Influence Of Extraversion On Brain Activity At Baseline, Pain Anticipation And Visceral Pain Processing. Gut vol. 63 Suppl 1, A32-A33.

Ruffle JK, Coen SJ, Farmer AD, Kano M, Gampietro V, Williams S, Aziz Q (2014). Influence of Extraversion on Brain Activity During Rest, Pain Anticipation and Visceral Pain Processing. GASTROENTEROLOGY. vol. 146, S847-S847.

Ruffle JK(2014). Molecular neurobiology of addiction: What's all the (Δ)FosB about?. American Journal of Drug and Alcohol Abuse vol. 40, (6) 428-437.