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Publications:  Dr Paul Pfeffer

Jolliffe DA, Stefanidis C, Wang Z, Kermani NZ, Dimitrov V, White JH, McDonough JE, Janssens W et al.(2020). Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med vol. 202, (3) 371-382.
10.1164/rccm.201909-1867OC
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64339
Wang E, Wechsler ME, Tran TN, Heaney LG, Jones RC, Menzies-Gow AN, Busby J, Jackson DJ et al.(2020). Characterization of Severe Asthma Worldwide: Data From the International Severe Asthma Registry. Chest vol. 157, (4) 790-804.
10.1016/j.chest.2019.10.053
Nixon R, Despiney R, Pfeffer P(2020). Case of paradoxical adverse response to mepolizumab with mepolizumab-induced alopecia in severe eosinophilic asthma. BMJ Case Reports vol. 13, (2)
10.1136/bcr-2019-233161
Glencross DA, Ho TR, Camiña N, Hawrylowicz CM, Pfeffer PE(2020). Air pollution and its effects on the immune system. Free Radical Biology and Medicine
10.1016/j.freeradbiomed.2020.01.179
van Bragt JJMH, Adcock IM, Bel EHD, Braunstahl GJ, ten Brinke A, Busby J, Canonica GW, Cao H et al.(2020). Characteristics and treatment regimens across ERS SHARP severe asthma registries. European Respiratory Journal vol. 55, (1)
10.1183/13993003.01163-2019
Wechsler M, Wang E, Canonica G, Heftier E, Jones R, Busby J, Heaney L, Pfeffer P et al. (2019). Epidemiology of lung function in a global severe asthma population. EUROPEAN RESPIRATORY JOURNAL. vol. 54,
10.1183/13993003.congress-2019.PA5023
Busby J, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqu S, Heaney LG, Chaudhuri R, Pfeffer PE (2019). Late Breaking Abstract - Characteristics of Patients Diagnosed with Severe Asthma at UK Specialist Centres: Variation by Ethnicity. EUROPEAN RESPIRATORY JOURNAL. vol. 54,
10.1183/13993003.congress-2019.PA2682
Busby J, Pfeffer PE, Jackson DJ, Mansur AH, Menzies-Gow A, Siddiqu S, Chaudhuri R, Heaney LG (2019). Late Breaking Abstract - Characteristics of T2-biomarker low severe asthma patients in the UK Severe Asthma Registry (UKSAR). EUROPEAN RESPIRATORY JOURNAL. vol. 54,
10.1183/13993003.congress-2019.PA2788
Agrawal SG, Pfeffer PE, Lewis White P(2019). 13th Annual Fungal Update Conference. Medical Mycology vol. 57, S257-S258.
10.1093/mmy/myz065
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58676
Dimeloe S, Rice LV, Chen H, Cheadle C, Raynes J, Pfeffer P, Lavender P, Richards DF et al.(2019). Vitamin D (1,25(OH) <inf>2</inf> D3) induces α-1-antitrypsin synthesis by CD4 <sup>+</sup> T cells, which is required for 1,25(OH) <inf>2</inf> D3-driven IL-10. Journal of Steroid Biochemistry and Molecular Biology vol. 189, 1-9.
10.1016/j.jsbmb.2019.01.014
Mann EH, Gabryšová L, Pfeffer PE, O¿Garra A, Hawrylowicz CM(2019). High-dose IL-2 skews a glucocorticoid-driven IL-17 <sup>+</sup> IL-10 <sup>+</sup> memory CD4 <sup>+</sup> T cell response towards a single IL-10–producing phenotype. Journal of Immunology vol. 202, (3) 684-693.
10.4049/jimmunol.1800697
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56008
Pfeffer PE, Mudway IS(2018). The impact of real-world particulate matter air pollution on the airways of susceptible individuals. American Journal of Respiratory and Critical Care Medicine vol. 198, (11) 1362-1363.
10.1164/rccm.201807-1206ED
Broadbent C, Pfeffer P, Steed L, Walker S (2018). Patient-reported side effects of oral corticosteroids. EUROPEAN RESPIRATORY JOURNAL. vol. 52,
10.1183/13993003.congress-2018.PA3144
Pfeffer PE, Lu H, Mann EH, Chen Y-H, Ho T-R, Cousins DJ, Corrigan C, Kelly FJ et al.(2018). Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter. PLoS One vol. 13, (8) e0200040-e0200040.
10.1371/journal.pone.0200040
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44904
Pfeffer PE, Donaldson GC, Mackay AJ, Wedzicha JA(2018). Increased COPD Exacerbations of Likely Viral Etiology Follow Elevated Ambient NOx. Am J Respir Crit Care Med
10.1164/rccm.201712-2506OC
https://qmro.qmul.ac.uk/xmlui/handle/123456789/44683
Pfeffer PE, Hawrylowicz CM(2018). Vitamin D in Asthma: Mechanisms of Action and Considerations for Clinical Trials. Chest vol. 153, (5) 1229-1239.
10.1016/j.chest.2017.09.005
Pfeffer PE(2018). Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma?. Expert Review of Clinical Immunology vol. 14, (4) 241-243.
10.1080/1744666X.2018.1440207
Pfeffer PE, Ho TR, Mann EH, Kelly FJ, Sehlstedt M, Pourazar J, Dove RE, Sandstrom T et al.(2018). Urban particulate matter stimulation of human dendritic cells enhances priming of naive CD8 T lymphocytes. Immunology vol. 153, (4) 502-512.
10.1111/imm.12852
https://qmro.qmul.ac.uk/xmlui/handle/123456789/49608
PETERSEN SE, AUNG N, FUNG K, ZEMRAK F, PAIVA J, Thomson R, SANGHVI M, LEE A et al.(2018). Variation in lung function and alterations in cardiac structure and function - analysis of the UK Biobank cardiovascular magnetic resonance imaging substudy. PLOS ONE vol. 13, (3)
10.1371/journal.pone.0194434
https://qmro.qmul.ac.uk/xmlui/handle/123456789/39226
Donaldson GC, Pfeffer PE, Mackay AJ, Wedzicha JA (2018). Ambient Particulate Matter and Oxides of Nitrogen Are Associated with an Increased Incidence of COPD Exacerbations with Symptoms of Infective Etiology. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 197,
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM(2018). Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids. Clinical and Experimental Allergy vol. 48, (1) 13-22.
10.1111/cea.13061
https://qmro.qmul.ac.uk/xmlui/handle/123456789/31212
Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, Weiss ST, Carey VJ et al.(2018). Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial. Journal of Allergy and Clinical Immunology vol. 141, (1) 269-278.e1.
10.1016/j.jaci.2017.02.039
https://qmro.qmul.ac.uk/xmlui/handle/123456789/55496
Mann EH, Pfeffer PE, Hawrylowicz CM(2017). Vitamin D and Adaptive Immunology in Health and Disease. Vitamin D: Fourth Edition, vol. 2,
Singer AM, Barrett J, Ali FR, Lambourne J, Pfeffer PE (2017). LATENT HELMINTH DISEASE AS A CAUSE OF EOSINOPHILIA IN RESPIRATORY PATIENTS. THORAX. vol. 72, A92-A93.
10.1136/thoraxjnl-2017-210983.162
Kumar A, Bicer EM, Pfeffer P, Monopoli MP, Dawson KA, Eriksson J, Edwards K, Lynham S et al.(2017). Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans. Nanomedicine: Nanotechnology, Biology, and Medicine vol. 13, (8) 2517-2521.
10.1016/j.nano.2017.06.008
Mann EH, Ho TR, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ, Hawrylowicz CM(2017). Vitamin D counteracts an IL-23-dependent IL-17A1IFN-g1 response driven by urban particulate matter. American Journal of Respiratory Cell and Molecular Biology vol. 57, (3) 355-366.
10.1165/rcmb.2016-0409OC
https://qmro.qmul.ac.uk/xmlui/handle/123456789/56771
Pfeffer PE, Hopkins S, Cropley I, Lowe DM, Lipman M(2017). An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation. Respiratory Research vol. 18, (1)
10.1186/s12931-017-0579-9
https://qmro.qmul.ac.uk/xmlui/handle/123456789/50663
Pfeffer PE, Corrigan CJ(2017). An imbalance between proteases and endogenous protease inhibitors in eosinophilic airway disease. American Journal of Respiratory and Critical Care Medicine vol. 195, (6) 707-708.
10.1164/rccm.201610-2020ED
Pfeffer P, Burman M, Milton V, Naidu V, Vaghela D, Kunst H (2016). Eosinophilia and predominant Th2 immune responses are rarely evident in disseminated tuberculosis. EUROPEAN RESPIRATORY JOURNAL. vol. 48,
10.1183/13993003.congress-2016.PA2704
Kumar A, Bicer EM, Morgan AB, Pfeffer PE, Monopoli M, Dawson KA, Eriksson J, Edwards K et al.(2016). Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid. Nanomedicine: Nanotechnology, Biology, and Medicine vol. 12, (4) 1033-1043.
10.1016/j.nano.2015.12.369
Matthews NC, Pfeffer PE, Mann EH, Kelly FJ, Corrigan CJ, Hawrylowicz CM, Lee TH(2016). Urban particulate matter-activated human dendritic cells induce the expansion of potent inflammatory Th1, Th2, and Th17 effector cells. American Journal of Respiratory Cell and Molecular Biology vol. 54, (2) 250-262.
10.1165/rcmb.2015-0084OC
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ et al.(2015). Distinct endotypes of steroid-resistant asthma characterized by IL-17A<sup>high</sup> and IFN-γ<sup>high</sup> immunophenotypes: Potential benefits of calcitriol. Journal of Allergy and Clinical Immunology vol. 136, (3) 628-637.e4.
10.1016/j.jaci.2015.01.026
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6997
Pfeffer PE, Chen YH, Woszczek G, Matthews NC, Chevretton E, Gupta A, Saglani S, Bush A et al.(2015). Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33. Journal of Allergy and Clinical Immunology vol. 135, (3) 824-827.e3.
10.1016/j.jaci.2014.09.044
https://qmro.qmul.ac.uk/xmlui/handle/123456789/43947
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM (2014). Calcitriol restores glucocorticoid responsiveness in steroid resistant asthmatics through reduction of IL-17A. IMMUNOLOGY. vol. 143, 50-50.
https://qmro.qmul.ac.uk/xmlui/handle/123456789/6668
Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen YH, Rice L, Hawrylowicz CM(2014). Vitamin D influences asthmatic pathology through its action on diverse immunological pathways. Annals of the American Thoracic Society vol. 11, S314-S321.
10.1513/AnnalsATS.201405-204AW
Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM(2014). Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Annals of the New York Academy of Sciences vol. 1317, (1) 57-69.
10.1111/nyas.12410
Tribuddharat S, Suwannasaen D, Sathitkarnmanee T, Ngamsangsirisup K, Hawrylowicz C, Pfeffer P, Hurst CP, Silarat S et al.(2014). Prognostic scoring models can be surrogates of plasma cytokine levels and predict a prolonged intensive care unit stay in cardiac surgery. Experimental and Clinical Cardiology vol. 20, (7) 329-357.
Matthews NC, Faith A, Pfeffer P, Lu H, Kelly FJ, Hawrylowicz CM, Lee TH(2014). Urban particulate matter suppresses priming of T helper type 1 cells by granulocyte/macrophage colony-stimulating factor-activated human dendritic cells. American journal of respiratory cell and molecular biology vol. 50, (2) 281-291.
10.1165/rcmb.2012-0465OC
José RJ, Pfeffer PE, McDonald I, Shaw S, Padate B, McNamara C, Kibbler C, Agarwal B(2012). Outcomes and patterns of infections in patients with underlying haematological malignancies admitted to intensive care. British Journal of Anaesthesia vol. 109, (2) 291-292.
10.1093/bja/aes242
Pfeffer PE, Pfeffer JM(2012). Psychiatric aspects. Sarcoidosis,
Pfeffer PE, Hawrylowicz CM(2012). Vitamin D and lung disease. Thorax vol. 67, (11) 1018-1020.
10.1136/thoraxjnl-2012-202139
Pfeffer PE, Nazareth D, Main N, Hardoon S, Choudhury AB(2011). Are weekend handovers of adequate quality for the on-call general medical team?. Clinical Medicine, Journal of the Royal College of Physicians of London vol. 11, (6) 536-540.
10.7861/clinmedicine.11-6-536
José R, McDonald I, Pfeffer P, Shaw S, Agarwal B(2011). Outcome of haematology patients admitted to intensive care in a tertiary centre: primary haematological diagnosis, recent chemotherapy and bone marrow transplantation are not associated with outcome. Critical care (London, England) vol. 15, (Suppl 1) P497-P497.
10.1186/cc9917
José R, McDonald I, Pfeffer P, Shaw S, Kibbler C, Agarwal B(2011). Patterns of infection and impact on outcome in haematology patients admitted to intensive care. Critical care (London, England) vol. 15, (Suppl 1) P496-P496.
10.1186/cc9916
Pfeffer PE, Sen A, Das S, Sheaff M, Sivaramakrishnan A, Simcock DE, Turner B(2010). Eosinophilia, meningitis and pulmonary nodules in a young woman. Thorax vol. 65, (12) 1066-1067.
10.1136/thx.2010.140350
Pfeffer PE, Sebire N, Lindsay I, McIndoe A, Lim A, Seckl M(2007). Fertility-sparing partial hysterectomy for placental-site trophoblastic tumour. Lancet Oncology vol. 8, (8) 744-746.
10.1016/S1470-2045(07)70243-7
Pfeffer PE, Pfeffer JM, Hodson ME(2003). The psychosocial and psychiatric side of cystic fibrosis in adolescents and adults. Journal of Cystic Fibrosis vol. 2, (2) 61-68.
10.1016/S1569-1993(03)00020-1
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