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Research

Publications: Mr Duco Koenis

Koenis DS, de Matteis R, Rajeeve V, Cutillas P, Dalli J ( 2023 ) . Efferocyte‐Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1‐Mediated Activation of Glycolysis . Advanced Science vol. 11 , ( 7 )
Ervik K, Reinertsen AF, Koenis DS, Dalli J, Hansen TV ( 2023 ) . Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5n‑3 DPA . Journal of Natural Products vol. 86 , ( 11 ) 2546 - 2553 .
Kurakula K, Sommer D, Sokolovic M, Moerland PD, Scheij S, van Loenen PB, Koenis DS, Zelcer N et al. ( 2023 ) . LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis . Molecular and Cellular Biology vol. 35 , ( 1 ) 52 - 62 .
Flak MB, Koenis DS, Gonzalez-Nunez M, Chopo-Pizarro A, Dalli J ( 2022 ) . Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation . Biochemical Pharmacology vol. 207 ,
Nelson JK, Thin MZ, Evan T, Howell S, Wu M, Almeida B, Legrave N, Koenis DS et al. ( 2022 ) . USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer . Nature Communications vol. 13 , ( 1 )
Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J et al. ( 2022 ) . MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis . EBioMedicine vol. 79 ,
Pistorius K, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M et al. ( 2022 ) . MCTR3 reprogramming arthritic monocytes to exert pro-resolving and tissue-protective functions in inflammatory arthritis . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 103 , A5 - A6 .
Beegun I, Koenis DS, Alusi G, Dalli J ( 2021 ) . Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis . Frontiers in Immunology vol. 12 ,
Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K et al. ( 2021 ) . Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19 . Circulation ResearchE54 - E71 .
Jagusch H, Werner M, Koenis D, Dalli J, Werz O, Pohnert G ( 2021 ) . 14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae . ACS Pharmacology & Translational Science vol. 4 , ( 3 ) 1188 - 1194 .
Marinković G, Koenis DS, de Camp L, Jablonowski R, Graber N, de Waard V, de Vries CJ, Goncalves I et al. ( 2020 ) . S100A9 Links Inflammation and Repair in Myocardial Infarction . Circulation Research vol. 127 , ( 5 ) 664 - 676 .
van der Stoel M, Schimmel L, Nawaz K, van Stalborch A-M, de Haan A, Klaus-Bergmann A, Valent ET, Koenis DS et al. ( 2020 ) . DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis . J Cell Sci
Flak MB, Koenis DS, Sobrino A, Smith J, Pistorius K, Palmas F, Dalli J ( 2019 ) . GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections . Journal of Clinical Investigation vol. 130 , ( 1 ) 359 - 373 .
Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Gogh IJE-V, Van den Bossche J et al. ( 2018 ) . Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism . Cell Reports vol. 24 , ( 8 ) 2127 - 2140.e7 .
Koenis DS, Medzikovic L, Vos M, Beldman TJ, van Loenen PB, van Tiel CM, Hamers AAJ, Otermin Rubio I et al. ( 2018 ) . Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans . Journal of Biological Chemistry vol. 293 , ( 39 ) 15070 - 15083 .
Medzikovic L, van Roomen C, Baartscheer A, van Loenen PB, de Vos J, Bakker ENTP, Koenis DS, Damanafshan A et al. ( 2018 ) . Nur77 protects against adverse cardiac remodelling by limiting Neuropeptide Y signalling in the sympathoadrenal-cardiac axis . Cardiovasc Res
Kurakula K, Koenis DS, Herzik MA, Liu Y, Craft JW, van Loenen PB, Vos M, Tran MK et al. ( 2018 ) . Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity . Haematologica vol. 103 , ( 6 ) 1073 - 1082 .
Cook ECL, Nelson JK, Sorrentino V, Koenis D, Moeton M, Scheij S, Ottenhoff R, Bleijlevens B et al. ( 2017 ) . Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene . PLOS ONE vol. 12 , ( 2 )
Nelson JK, Koenis DS, Scheij S, Cook ECL, Moeton M, Santos A, Lobaccaro J-MA, Baron S et al. ( 2017 ) . EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 3 ) 423 - 432 .
Hamers AAJ, Argmann C, Moerland PD, Koenis DS, Marinković G, Sokolović M, de Vos AF, de Vries CJM et al. ( 2016 ) . Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance . BMC Genomics vol. 17 , ( 1 )
Tran MK, Kurakula K, Koenis DS, de Vries CJM ( 2015 ) . Protein–protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease . Biochimica et Biophysica Acta vol. 1863 , ( 2 ) 219 - 228 .
Kurakula K, Koenis DS, van Tiel CM, de Vries CJM ( 2014 ) . NR4A nuclear receptors are orphans but not lonesome . Biochimica et Biophysica Acta vol. 1843 , ( 11 ) 2543 - 2555 .
van Tiel CM, Kurakula K, Koenis DS, van der Wal E, de Vries CJM ( 2012 ) . Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability . Biochimica et Biophysica Acta vol. 1823 , ( 10 ) 1894 - 1904 .