Publications: Prof Victoria Marta Sanz-Moreno
Barcelo J, Samain R, Sanz-Moreno V
(
2023
)
.
Preclinical to clinical utility of ROCK inhibitors in cancer
.
Trends in Cancer
vol.
9
,
(
3
)
250
-
263
.
George S, Martin JAJ, Graziani V, Sanz-Moreno V
(
2023
)
.
Amoeboid migration in health and disease: Immune responses versus cancer dissemination
.
Frontiers in Cell and Developmental Biology
vol.
10
,
Jung-Garcia Y, Maiques O, Monger J, Rodriguez-Hernandez I, Fanshawe B, Domart MC, Renshaw MJ, Marti RM et al.
(
2023
)
.
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion
.
Nature Cell Biology
vol.
25
,
(
1
)
108
-
119
.
Maiques O, Sanz-Moreno V
(
2022
)
.
Multiplex chromogenic immunohistochemistry to stain and analyze paraffin tissue sections from the mouse or human
.
STAR Protocols
vol.
3
,
(
4
)
George S, Georgouli M, Sanz-Moreno V
(
2022
)
.
Protocol to drive human monocyte-to-macrophage polarization in vitro using tumor conditioned media
.
STAR Protocols
vol.
3
,
(
4
)
Barcelo J, Sanz-Moreno V
(
2022
)
.
NECTIN1 is a melanoma metastasis suppressor gene
.
Nature Genetics
vol.
54
,
(
12
)
1776
-
1777
.
Perdrix Rosell A, Maiques O, Martin JAJ, Chakravarty P, Ombrato L, Sanz-Moreno V, Malanchi I
(
2022
)
.
Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth
.
Cancer Letters
vol.
544
,
Roy-Luzarraga M, Reynolds LE, de Luxán-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG et al.
(
2022
)
.
Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment
.
Cancer Research
vol.
82
,
(
10
)
1909
-
1925
.
Graziani V, Rodriguez-Hernandez I, Maiques O, Sanz-Moreno V
(
2022
)
.
The amoeboid state as part of the epithelial-to-mesenchymal transition programme
.
Trends in Cell Biology
vol.
32
,
(
3
)
228
-
242
.
Adams R, Osborn G, Mukhia B, Laddach R, Willsmore Z, Chenoweth A, Geh JLC, MacKenzie Ross AD et al.
(
2022
)
.
Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies
.
OncoImmunology
vol.
11
,
(
1
)
Maiques O, Sanz-Moreno V
(
2022
)
.
Location, location, location: Melanoma cells “living at the edge”
.
Experimental Dermatology
vol.
31
,
(
1
)
82
-
88
.
Crosas-Molist E, Samain R, Kohlhammer L, Orgaz JL, George SL, Maiques O, Barcelo J, Sanz-Moreno V
(
2022
)
.
RHO GTPase SIGNALING IN CANCER PROGRESSION AND DISSEMINATION
.
Physiological Reviews
vol.
102
,
(
1
)
455
-
510
.
de Winde CM, George SL, Crosas-Molist E, Hari-Gupta Y, Arp AB, Benjamin AC, Millward LJ, Makris S et al.
(
2021
)
.
Podoplanin drives dedifferentiation and amoeboid invasion of melanoma
.
iScience
vol.
24
,
(
9
)
Maiques O, Fanshawe B, Crosas-Molist E, Rodriguez-Hernandez I, Volpe A, Cantelli G, Boehme L, Orgaz JL et al.
(
2021
)
.
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
.
British Journal of Cancer
vol.
125
,
(
5
)
699
-
713
.
Candido JB, Maiques O, Boxberg M, Kast V, Peerani E, Tomás-bort E, Weichert W, Sananes A et al.
(
2021
)
.
Kallikrein-related peptidase 6 is associated with the tumour microenvironment of pancreatic ductal adenocarcinoma
.
Cancers
vol.
13
,
(
16
)
Jung-Garcia Y, Maiques O, Rodriguez-Hernandez I, Fanshawe B, Domart M-C, Renshaw M, Marti R, Matias-Guiu X et al.
(
2021
)
.
LAP1 supports nuclear plasticity during constrained migration
.
Rosell AP, Maiques O, Chakravarty P, Ombrato L, Sanz-Moreno V, Malanchi I
(
2021
)
.
Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth
.
Rodriguez-Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix-Rosell A, Monger J, Fanshawe B, Bridgeman VL et al.
(
2020
)
.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
.
Nature Communications
vol.
11
,
(
1
)
McLeod R, Kumar R, Papadatos-Pastos D, Mateo J, Brown JS, Ingles Garces AH, Ruddle R, Decordova S et al.
(
2020
)
.
First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors
.
Clinical Cancer Research
vol.
26
,
(
18
)
4777
-
4784
.
Farrugia AJ, Rodríguez J, Orgaz JL, Lucas M, Sanz-Moreno V, Calvo F
(
2020
)
.
CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion
.
Journal of Cell Biology
vol.
219
,
(
9
)
Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O et al.
(
2020
)
.
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
.
Cell
vol.
181
,
(
6
)
1346
-
1363.e21
.
Orgaz JL, Sanz-Moreno V
(
2020
)
.
What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
.
Molecular and Cellular Oncology
vol.
7
,
(
3
)
Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y et al.
(
2020
)
.
Erratum: PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells (Cell Reports (2019) 29(11) (3385–3393.e6), (S2211124719314871), (10.1016/j.celrep.2019.11.016))
.
Cell Reports
vol.
31
,
(
3
)
Samain R, Sanz-Moreno V
(
2020
)
.
Cancer-associated fibroblasts: activin A adds another string to their bow
.
EMBO Molecular Medicine
vol.
12
,
(
4
)
Orgaz JL, Crosas-Molist E, Sadok A, Perdrix-Rosell A, Maiques O, Rodriguez-Hernandez I, Monger J, Mele S et al.
(
2020
)
.
Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
.
Cancer Cell
vol.
37
,
(
1
)
85
-
103.e9
.
Valcarcel-Jimenez L, Macchia A, Crosas-Molist E, Schaub-Clerigue A, Camacho L, Martín-Martín N, Cicogna P, Viera-Bardon C et al.
(
2019
)
.
PGC1a suppresses prostate cancer cell invasion through ERRA transcriptional control
.
Cancer Research
vol.
79
,
(
24
)
6153
-
6165
.
Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y et al.
(
2019
)
.
PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
.
Cell Reports
vol.
29
,
(
11
)
3385
-
3393.e6
.
Rosel D, Fernandes M, Sanz-Moreno V, Brábek J
(
2019
)
.
Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?
.
Trends in Cancer
vol.
5
,
(
12
)
755
-
756
.
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.
(
2019
)
.
Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease
.
Journal of Pathology
vol.
249
,
(
4
)
523
-
535
.
López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Malfettone A, Caja L, Serrano T, Ramos E et al.
(
2019
)
.
Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition
.
Cancer Letters
vol.
464
,
15
-
24
.
Farrugia A, Rodríguez J, Orgaz J, Lucas M, Sanz-Moreno V, Calvo F
(
2019
)
.
Cdc42EP5/BORG3 modulates SEPT9 to promote actomyosin function and melanoma invasion and metastasis
.
Rodrigo JP, Diaz RG, Villaronga MA, Prado FH, Menendez ST, Quer M, Vilaseca I, Canteli MS et al.
(
2019
)
.
PO-108 Clinical relevance of Cortactin and Focal Adhesion Kinase as predictors of laryngeal cancer risk
.
Radiotherapy and Oncology
vol.
132
,
Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Rodriguez-Hernandez I et al.
(
2019
)
.
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment
.
Cell
vol.
176
,
(
4
)
757
-
774.e23
.
Maiques O, Georgouli M, Sanz-Moreno V
(
2019
)
.
Recent advances in tissue imaging for cancer research [version 1; peer review: 2 approved]
.
F1000Research
vol.
8
,
Muliaditan T, Caron J, Okesola M, Opzoomer JW, Kosti P, Georgouli M, Gordon P, Lall S et al.
(
2018
)
.
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
.
Nature Communications
vol.
9
,
(
1
)
Sanz-Moreno V, Balkwill FR
(
2018
)
.
Mets and NETs: The Awakening Force
.
Immunity
vol.
49
,
(
5
)
798
-
800
.
Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F, Murga C
(
2018
)
.
Erratum: Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK (Current Biology (2006) 16(20) (2042–2047) (S0960982206021518) (10.1016/j.cub.2006.08.083))
.
Current Biology
vol.
28
,
(
15
)
Villaronga MÁ, Hermida-Prado F, Granda-Díaz R, Menéndez ST, Álvarez-Teijeiro S, Quer M, Vilaseca I, Allonca E et al.
(
2018
)
.
Immunohistochemical expression of cortactin and focal adhesion kinase predicts recurrence risk and laryngeal cancer risk beyond histologic grading
.
Cancer Epidemiology Biomarkers and Prevention
vol.
27
,
(
7
)
805
-
813
.
Maiques O, Barceló C, Panosa A, Pijuan J, Orgaz JL, Rodriguez-Hernandez I, Matas-Nadal C, Tell G et al.
(
2018
)
.
T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1
.
Pigment Cell and Melanoma Research
vol.
31
,
(
4
)
484
-
495
.
O'Donnell MA
(
2018
)
.
Victoria Sanz-Moreno: Rho together for cancer research
.
J Cell Biol
vol.
217
,
(
6
)
1885
-
1886
.
(
2018
)
.
R10 (Quail)
.
Encyclopedia of Signaling Molecules
,
Orgaz JL, Sanz-Moreno V
(
2018
)
.
RhoA
.
Encyclopedia of Signaling Molecules
,
Wells C, Lam H, Sanz-Moreno V, Sabin V, Sarker D
(
2018
)
.
3D spheroid invasion drug screen platform for pancreatic ductal adenocarcinoma
.
Journal of Clinical Oncology
vol.
36
,
(
15_suppl
)
e24212
-
e24212
.
Krupina K, Kleiss C, Awal S, Rodriguez-Hernandez I, Sanz-Moreno V, Sumara I
(
2018
)
.
UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer
.
Molecular and Cellular Oncology
vol.
5
,
(
2
)
Villaronga MÁ, Teijeiro SÁ, Hermida-Prado F, Garzón-Arango M, Sanz-Moreno V, García-Pedrero JM
(
2018
)
.
Analysis of invasive activity of CAF spheroids into three dimensional (3D) collagen matrices
.
Methods in Molecular Biology
,
vol.
1731
,
Pandya P, Orgaz JL, Sanz-Moreno V
(
2017
)
.
Actomyosin contractility and collective migration: may the force be with you
.
Current Opinion in Cell Biology
vol.
48
,
87
-
96
.
Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G et al.
(
2017
)
.
Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
.
Nat Cell Biol
vol.
19
,
(
7
)
Gandalovičová A, Rosel D, Fernandes M, Veselý P, Heneberg P, Čermák V, Petruželka L, Kumar S et al.
(
2017
)
.
Migrastatics—Anti-metastatic and Anti-invasion Drugs: Promises and Challenges
.
Trends in Cancer
vol.
3
,
(
6
)
391
-
406
.
Crosas-Molist E, Bertran E, Rodriguez-Hernandez I, Herraiz C, Cantelli G, Fabra A, Sanz-Moreno V, Fabregat I
(
2017
)
.
The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination
.
Oncogene
vol.
36
,
(
21
)
3002
-
3014
.
Sanz-Moreno V
(
2017
)
.
Cell scientist to watch - Victoria Sanz-Moreno
.
Journal of Cell Science
vol.
130
,
(
7
)
1199
-
1200
.
Talamillo A, Grande L, Ruiz-Ontañon P, Velasquez C, Mollinedo P, Torices S, Sanchez-Gomez P, Aznar A et al.
(
2017
)
.
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA
.
Oncogene
vol.
36
,
(
12
)
1733
-
1744
.
Josephs DH, Bax HJ, Dodev T, Georgouli M, Nakamura M, Pellizzari G, Saul L, Karagiannis P et al.
(
2017
)
.
Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNFa/MCP-1 signaling
.
Cancer Research
vol.
77
,
(
5
)
1127
-
1141
.
Cantelli G, Crosas-Molist E, Georgouli M, Sanz-Moreno V
(
2017
)
.
TGFΒ-induced transcription in cancer
.
Seminars in Cancer Biology
vol.
42
,
60
-
69
.
Pandya P, Orgaz JL, Sanz-Moreno V
(
2017
)
.
Modes of invasion during tumour dissemination
.
Molecular Oncology
vol.
11
,
(
1
)
5
-
27
.
Orgaz JL, Sanz-Moreno V
(
2016
)
.
RhoA
.
Encyclopedia of Signaling Molecules
,
Saul L, Ilieva KM, Bax HJ, Karagiannis P, Correa I, Rodriguez-Hernandez I, Josephs DH, Tosi I et al.
(
2016
)
.
Abstract A116: IgG antibody switching and clonal expansion in melanoma and normal skin microenvironments
.
Conference:
Cancer Immunology Research AACRa116
-
a116
.
Saul L, Ilieva KM, Bax HJ, Karagiannis P, Correa I, Rodriguez-Hernandez I, Josephs DH, Tosi I et al.
(
2016
)
.
IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin
.
Scientific Reports
vol.
6
,
Valcarcel L, Torrano V, Cortazar AR, Liu X, Urosevic J, Castillo M, Morciano G, Graupera M et al.
(
2016
)
.
756 Transcriptional regulation of prostate cancer metabolism
.
European Journal of Cancer
vol.
61
,
Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G et al.
(
2016
)
.
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
.
Nature Cell Biology
vol.
18
,
(
6
)
645
-
656
.
Herraiz C, Crosas-Molist E, Sanz-Moreno V
(
2016
)
.
Reactive oxygen species and tumor dissemination: Allies no longer
.
Molecular and Cellular Oncology
vol.
3
,
(
2
)
Herraiz C, Calvo F, Pandya P, Cantelli G, Rodriguez-Hernandez I, Orgaz JL, Kang N, Chu T et al.
(
2016
)
.
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance between DNA Damage and Tumor Dissemination
.
Journal of the National Cancer Institute
vol.
108
,
(
1
)
Rodriguez-Hernandez I, Cantelli G, Bruce F, Sanz-Moreno V
(
2016
)
.
Rho, ROCK and actomyosin contractility in metastasis as drug targets [version 1; referees: 2 approved]
.
F1000Research
vol.
5
,
Albrengues J, Bertero T, Grasset E, Bonan S, Maiel M, Bourget I, Philippe C, Herraiz Serrano C et al.
(
2015
)
.
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
.
Nature Communications
vol.
6
,
Cantelli G, Orgaz JL, Rodriguez-Hernandez I, Karagiannis P, Maiques O, Matias-Guiu X, Nestle FO, Marti RM et al.
(
2015
)
.
TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination
.
Current Biology
vol.
25
,
(
22
)
2899
-
2914
.
Masuzzo P, Martens L, Ampe C, Anderson KI, Barry J, De Wever O, Debeir O, Decaes-Tecker C et al.
(
2015
)
.
An open data ecosystem for cell migration research
.
Trends in Cell Biology
vol.
25
,
(
2
)
55
-
58
.
Orgaz JL, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A, Albrengues J, Nestle FO et al.
(
2014
)
.
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration
.
Nature Communications
vol.
5
,
Orgaz JL, Herraiz C, Sanz-Moreno V
(
2014
)
.
Rho GTPases modulate malignant transformation of tumor cells
.
Small GTPases
vol.
5
,
(
MAY
)
Ruiz-Ontañon P, Orgaz JL, Aldaz B, Elosegui-Artola A, Martino J, Berciano MT, Montero JA, Grande L et al.
(
2013
)
.
Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue
.
Stem Cells
vol.
31
,
(
6
)
1075
-
1085
.
Orgaz JL, Sanz-Moreno V
(
2013
)
.
Emerging molecular targets in melanoma invasion and metastasis
.
Pigment Cell and Melanoma Research
vol.
26
,
(
1
)
39
-
57
.
Ramasamy K, Lekgetho H, Orgaz JL, Anwar A, Sanz-Moreno V, Kazmi MA, Schey S, Calle Y
(
2012
)
.
Beta7 Integrins Regulate Podia Formation in Multiple Myeloma (MM) Cells for the Interaction with the Cellular and Non-Cellular Bone Marrow (BM) Stroma
.
Blood
vol.
120
,
(
21
)
3979
-
3979
.
Ahn J, Sanz-Moreno V, Marshall CJ
(
2012
)
.
The metastasis gene NEDD9 product acts through integrin β3 and Src to promote mesenchymal motility and inhibit amoeboid motility
.
Journal of Cell Science
vol.
125
,
(
7
)
1814
-
1826
.
Sanz-Moreno V
(
2012
)
.
Tumour invasion: A new twist on Rac-driven mesenchymal migration
.
Current Biology
vol.
22
,
(
11
)
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P
(
2011
)
.
Erratum: RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation (Nature Cell Biology (2011) 13 (819-826))
.
Nature Cell Biology
vol.
13
,
(
8
)
Sanz-Moreno V, Gaggioli C, Yeo M, Albrengues J, Wallberg F, Viros A, Hooper S, Mitter R et al.
(
2011
)
.
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
.
Cancer Cell
vol.
20
,
(
2
)
229
-
245
.
Crespo P, Calvo F, Sanz-Moreno V
(
2011
)
.
Ras and Rho GTPases on the move: The RasGRF connection
.
BioArchitecture
vol.
1
,
(
4
)
200
-
204
.
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P
(
2011
)
.
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation
.
Nature Cell Biology
vol.
13
,
(
7
)
819
-
826
.
Sanz-Moreno V, Marshall CJ
(
2010
)
.
The plasticity of cytoskeletal dynamics underlying neoplastic cell migration
.
Current Opinion in Cell Biology
vol.
22
,
(
5
)
690
-
696
.
Sanz-Moreno V, Marshall CJ
(
2009
)
.
Rho-GTPase signaling drives melanoma cell plasticity
.
Cell Cycle
vol.
8
,
(
10
)
1484
-
1487
.
Casar B, Arozarena I, Sanz-Moreno V, Pinto A, Agudo-Ibáñez L, Marais R, Lewis RE, Berciano MT et al.
(
2009
)
.
Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins
.
Molecular and Cellular Biology
vol.
29
,
(
5
)
1338
-
1353
.
Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, Sahai E, Marshall CJ
(
2008
)
.
Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
.
Cell
vol.
135
,
(
3
)
510
-
523
.
Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ
(
2008
)
.
DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells
.
Current Biology
vol.
18
,
(
19
)
1456
-
1465
.
Sanz-Moreno V, Gadea G, Paterson H, Marshall CJ
(
2008
)
.
Rac activation and inactivation control plasticity of tumour cell movement
.
European Journal of Cancer Supplements
vol.
6
,
(
9
)
Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P
(
2007
)
.
Mxi2 promotes stimulus-independent ERK nuclear translocation
.
EMBO Journal
vol.
26
,
(
3
)
635
-
646
.
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