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Publications:  Prof Kamil Kranc

Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al.(2021). The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. The Journal of experimental medicine vol. 218, (3)
10.1084/jem.20200829
Baumeister J, Chatain N, Hubrich A, Maié T, Costa IG, Denecke B, Han L, Küstermann C et al.(2020). Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms. Leukemia vol. 34, (4) 1062-1074.
10.1038/s41375-019-0629-z
Luis TC, Lawson H, Kranc KR(2020). Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells. Cell Stem Cell vol. 26, (3) 299-301.
10.1016/j.stem.2020.02.009
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K et al.(2019). Systemic silencing of Phd2 causes reversible immune regulatory dysfunction. Journal of Clinical Investigation vol. 129, (9) 3640-3656.
10.1172/JCI124099
Menendez-Gonzalez JB, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas LA, Agirre-Lizaso A, Azevedo A et al.(2019). Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia. Stem Cell Reports vol. 13, (2) 291-306.
10.1016/j.stemcr.2019.07.005
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al.(2019). Targeting the RNA m<sup>6</sup>A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell vol. 25, (1) 137-148.e6.
10.1016/j.stem.2019.03.021
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.(2019). Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)). Cell vol. 178, (1)
10.1016/j.cell.2019.06.017
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.(2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell vol. 177, (5) 1201-1216.e19.
10.1016/j.cell.2019.03.018
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58280
Van De Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D(2018). CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands 06 Biological Sciences 0601 Biochemistry and Cell Biology 06 Biological Sciences 0604 Genetics. Epigenetics and Chromatin vol. 11, (1)
10.1186/s13072-018-0230-0
Guitart AV, Finch AJ, Kranc KR(2018). Ca<sup>2+</sup>tapulting HSCs into action. Journal of Experimental Medicine vol. 215, (8) 1971-1973.
10.1084/jem.20181097
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65483
Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A et al.(2018). hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood vol. 131, (14) 1532-1544.
10.1182/blood-2017-05-783845
O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DD, Carragher NO, Kranc KR(2018). Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions. Assay and Drug Development Technologies vol. 16, (1) 51-63.
10.1089/adt.2017.819
Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al.(2017). Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. The Journal of experimental medicine vol. 214, (3) 719-735.
10.1084/jem.20161087
https://qmro.qmul.ac.uk/xmlui/handle/123456789/59365
Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M et al.(2016). Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Genes and Development vol. 30, (19) 2173-2186.
10.1101/gad.284562.116
Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR et al.(2016). ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells. Autophagy vol. 12, (6) 936-948.
10.1080/15548627.2016.1162359
Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J et al.(2016). Adult hematopoietic stem cells lacking Hif-1α self-renew normally. Blood vol. 127, (23) 2841-2846.
10.1182/blood-2015-10-677138
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LEM, Kinstrie R, Guitart AV et al.(2016). CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood vol. 128, (3) 371-383.
10.1182/blood-2015-08-661785
Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J et al.(2015). Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. Journal of Experimental Medicine vol. 212, (13) 2223-2234.
10.1084/jem.20150452
Guitart AV, Vukovic M, Sepulveda C, Panagopoulou T, Allen L, Pollard P, Morton N, Finch A et al. (2015). Dual function of fumarate hydratase in haematopoietic stem cell fates. Experimental Hematology. vol. 43,
10.1016/j.exphem.2015.06.067
Kranc KR, Dzierzak E(2015). Relieving oxidative stress in immune cells. Journal of Experimental Medicine vol. 212, (8) 1140-1140.
10.1084/jem.2128insight1
Guitart AV, Vukovic M, Sas Z, Vila M, Sepulveda C, Panagopoulou T, Allen L, Pollard P et al. (2015). FUMARATE HYDRATASE IS AN ESSENTIAL REGULATOR OF EMBRYONIC AND ADULT HAEMATOPOIETIC STEM CELL. HAEMATOLOGICA. vol. 100, 123-123.
Vukovic M, Guitart AV, Kranc K (2015). HIF-2A IS A TUMOUR SUPPRESSOR IN AML. HAEMATOLOGICA. vol. 100, 10-10.
Sepulveda C, Guitart A, Vukovic M, Panagopoulou TI, Allen L, Lengelling A, Ratcliffe PJ, Kranc KR (2015). THE ROLE OF 2-OXOGLUTARATE DEPENDENT DIOXYGENASES IN NORMAL HAEMATOPOIESIS AND ACUTE MYELOID LEUKEMIA. HAEMATOLOGICA. vol. 100, 9-9.
Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Catarina Matias A, Luisa Escapa A, Subramani C, Wheadon H et al.(2015). Acute loss of Cited2 impairs nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells vol. 33, (3) 699-712.
10.1002/stem.1889
Yang M, Su H, Soga T, Kranc KR, Pollard PJ(2014). Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism. Hypoxia (Auckl) vol. 2, 127-142.
10.2147/HP.S47968
Sinclair A, Calaminus S, Pellicano F, Guitart A, Graham S, Poncz M, Graham G, Sansom O et al. (2013). CHEMOKINE SIGNALLING REGULATES HAEMOPOIETIC STEM CELL SURVIVAL. HAEMATOLOGICA. vol. 98, 391-392.
Guitart A, Pollard P, Holyoake T, Enver T, Ratcliffe P, Kranc K (2013). HIF-1ALPHA AND HIF-2APLPHA ARE NOT ESSENTIAL FOR STEADY-STATE HEMATOPOIETIC STEM CELL MAINTENANCE. HAEMATOLOGICA. vol. 98, 493-493.
Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K et al.(2013). Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. Blood vol. 122, (10) 1741-1745.
10.1182/blood-2013-02-484923
Calaminus SDJ, Guitart A, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM(2012). Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny. PLoS ONE vol. 7, (12)
10.1371/journal.pone.0051361
Sinclair A, Pellicano P, Graham SM, Kinstrie R, Kranc K, Graham G, Holyoake TL (2012). An investigation of the role of CXCL1-CXCR2 signalling in haemopoietic stem cell quiescence. BRITISH JOURNAL OF HAEMATOLOGY. vol. 157, 26-27.
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al.(2011). The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. Journal of Experimental Medicine vol. 208, (3) 455-467.
10.1084/jem.20101145
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al.(2011). The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. Journal of Cell Biology vol. 192, (5) i5-i5.
10.1083/jcb1925oia5
Pollard PJ, Kranc KR(2010). Hypoxia signaling in hematopoietic stem cells: A double-edged sword. Cell Stem Cell vol. 7, (3) 276-278.
10.1016/j.stem.2010.08.006
Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, Bouriez-Jones T, Sigvardsson M et al.(2009). Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells. Cell Stem Cell vol. 5, (6) 659-665.
10.1016/j.stem.2009.11.001
Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al.(2009). T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides (DOI:10.1016/j.immuni.2009.01.009). Immunity vol. 30, (4)
10.1016/j.immuni.2009.03.009
Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al.(2009). T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides. Immunity vol. 30, (3) 348-357.
10.1016/j.immuni.2009.01.009
Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI et al.(2006). Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature vol. 443, (7111) 574-577.
10.1038/nature05133
Clark JF, Pyne GJ, Tao LM, Claridge T, Harris D, Kranc K, Cadoux-Hudson T, Turnbull J et al. (2001). Oxidative degradation of bilirubin produces vasoactive compounds in subarachnoid hemorrhage patients with cerebral vasospasm. FASEB JOURNAL. vol. 15, A112-A112.
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