Publications:  Prof Kamil Kranc

Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al.(2021). The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. The Journal of experimental medicine vol. 218, (3)

Baumeister J, Chatain N, Hubrich A, Maié T, Costa IG, Denecke B, Han L, Küstermann C et al.(2020). Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms. Leukemia vol. 34, (4) 1062-1074.

Luis TC, Lawson H, Kranc KR(2020). Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells. Cell Stem Cell vol. 26, (3) 299-301.

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K et al.(2019). Systemic silencing of Phd2 causes reversible immune regulatory dysfunction. Journal of Clinical Investigation vol. 129, (9) 3640-3656.

Menendez-Gonzalez JB, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas LA, Agirre-Lizaso A, Azevedo A et al.(2019). Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia. Stem Cell Reports vol. 13, (2) 291-306.

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al.(2019). Targeting the RNA m⁶A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell vol. 25, (1) 137-148.e6.

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.(2019). Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)). Cell vol. 178, (1)

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.(2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell vol. 177, (5) 1201-1216.e19.

Van De Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D(2018). CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands 06 Biological Sciences 0601 Biochemistry and Cell Biology 06 Biological Sciences 0604 Genetics. Epigenetics and Chromatin vol. 11, (1)

Guitart AV, Finch AJ, Kranc KR(2018). Ca²⁺tapulting HSCs into action. Journal of Experimental Medicine vol. 215, (8) 1971-1973.

Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A et al.(2018). hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood vol. 131, (14) 1532-1544.

O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DD, Carragher NO, Kranc KR(2018). Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions. Assay and Drug Development Technologies vol. 16, (1) 51-63.

Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al.(2017). Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. The Journal of experimental medicine vol. 214, (3) 719-735.

Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M et al.(2016). Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Genes and Development vol. 30, (19) 2173-2186.

Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR et al.(2016). ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells. Autophagy vol. 12, (6) 936-948.

Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J et al.(2016). Adult hematopoietic stem cells lacking Hif-1α self-renew normally. Blood vol. 127, (23) 2841-2846.

Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LEM, Kinstrie R, Guitart AV et al.(2016). CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood vol. 128, (3) 371-383.

Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J et al.(2015). Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. Journal of Experimental Medicine vol. 212, (13) 2223-2234.

Guitart AV, Vukovic M, Sepulveda C, Panagopoulou T, Allen L, Pollard P, Morton N, Finch A et al. (2015). Dual function of fumarate hydratase in haematopoietic stem cell fates. Experimental Hematology. vol. 43,

Kranc KR, Dzierzak E(2015). Relieving oxidative stress in immune cells. Journal of Experimental Medicine vol. 212, (8) 1140-1140.

Guitart AV, Vukovic M, Sas Z, Vila M, Sepulveda C, Panagopoulou T, Allen L, Pollard P et al. (2015). FUMARATE HYDRATASE IS AN ESSENTIAL REGULATOR OF EMBRYONIC AND ADULT HAEMATOPOIETIC STEM CELL. HAEMATOLOGICA. vol. 100, 123-123.

Vukovic M, Guitart AV, Kranc K (2015). HIF-2A IS A TUMOUR SUPPRESSOR IN AML. HAEMATOLOGICA. vol. 100, 10-10.

Sepulveda C, Guitart A, Vukovic M, Panagopoulou TI, Allen L, Lengelling A, Ratcliffe PJ, Kranc KR (2015). THE ROLE OF 2-OXOGLUTARATE DEPENDENT DIOXYGENASES IN NORMAL HAEMATOPOIESIS AND ACUTE MYELOID LEUKEMIA. HAEMATOLOGICA. vol. 100, 9-9.

Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Catarina Matias A, Luisa Escapa A, Subramani C, Wheadon H et al.(2015). Acute loss of Cited2 impairs nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells vol. 33, (3) 699-712.

Yang M, Su H, Soga T, Kranc KR, Pollard PJ(2014). Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism. Hypoxia (Auckl) vol. 2, 127-142.

Sinclair A, Calaminus S, Pellicano F, Guitart A, Graham S, Poncz M, Graham G, Sansom O et al. (2013). CHEMOKINE SIGNALLING REGULATES HAEMOPOIETIC STEM CELL SURVIVAL. HAEMATOLOGICA. vol. 98, 391-392.

Guitart A, Pollard P, Holyoake T, Enver T, Ratcliffe P, Kranc K (2013). HIF-1ALPHA AND HIF-2APLPHA ARE NOT ESSENTIAL FOR STEADY-STATE HEMATOPOIETIC STEM CELL MAINTENANCE. HAEMATOLOGICA. vol. 98, 493-493.

Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K et al.(2013). Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. Blood vol. 122, (10) 1741-1745.

Calaminus SDJ, Guitart A, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM(2012). Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny. PLoS ONE vol. 7, (12)

Sinclair A, Pellicano P, Graham SM, Kinstrie R, Kranc K, Graham G, Holyoake TL (2012). An investigation of the role of CXCL1-CXCR2 signalling in haemopoietic stem cell quiescence. BRITISH JOURNAL OF HAEMATOLOGY. vol. 157, 26-27.

Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al.(2011). The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. Journal of Experimental Medicine vol. 208, (3) 455-467.

Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al.(2011). The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. Journal of Cell Biology vol. 192, (5) i5-i5.

Pollard PJ, Kranc KR(2010). Hypoxia signaling in hematopoietic stem cells: A double-edged sword. Cell Stem Cell vol. 7, (3) 276-278.

Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, Bouriez-Jones T, Sigvardsson M et al.(2009). Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells. Cell Stem Cell vol. 5, (6) 659-665.

Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al.(2009). T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides (DOI:10.1016/j.immuni.2009.01.009). Immunity vol. 30, (4)

Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al.(2009). T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides. Immunity vol. 30, (3) 348-357.

Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI et al.(2006). Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature vol. 443, (7111) 574-577.

Clark JF, Pyne GJ, Tao LM, Claridge T, Harris D, Kranc K, Cadoux-Hudson T, Turnbull J et al. (2001). Oxidative degradation of bilirubin produces vasoactive compounds in subarachnoid hemorrhage patients with cerebral vasospasm. FASEB JOURNAL. vol. 15, A112-A112.