Publications: Prof Kamil Kranc
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS et al.
(
2023
)
.
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
.
Nature Communications
vol.
14
,
(
1
)
Gorur V, Kranc KR, Ganuza M, Telfer P
(
2023
)
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Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders
.
Blood Reviews
Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K et al.
(
2022
)
.
MYC sensitises cells to apoptosis by driving energetic demand
.
Nature Communications
vol.
13
,
(
1
)
Sommerkamp P, Brown JA, Haltalli MLR, Mercier FE, Vu LP, Kranc KR
(
2022
)
.
m<sup>6</sup>A RNA modifications: Key regulators of normal and malignant hematopoiesis
.
Experimental Hematology
vol.
111
,
25
-
31
.
Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM et al.
(
2022
)
.
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
.
Nature Immunology
vol.
23
,
(
6
)
927
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939
.
Young C, Russell JR, Van De Lagemaat LN, Lawson H, Mapperley C, Kranc KR, Christophorou MA
(
2022
)
.
Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis
.
Biology Open
vol.
11
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(
6
)
Turner DJ, Saveliev A, Salerno F, Matheson LS, Screen M, Lawson H, Wotherspoon D, Kranc KR et al.
(
2022
)
.
A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells
.
eLife
vol.
11
,
Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM et al.
(
2022
)
.
Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (Nature Immunology, (2022), 23, 6, (927-939), 10.1038/s41590-022-01216-z)
.
Nature Immunology
Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C et al.
(
2021
)
.
CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation
.
Stem Cell Reports
vol.
16
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(
11
)
2784
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2797
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Adam J, Finch A, Sepulveda C, Ducker M, Torroba MB, Krell D, Kriaucionis S, Szele F et al.
(
2021
)
.
Elevated 2HG does not cause features of tumorigenesis
.
Neuro-Oncology
.
vol.
23
,
iv1
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iv1
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Codino A, Turowski T, van de Lagemaat LN, Ivanova I, Tavosanis A, Much C, Auchynnikava T, Vasiliauskaitė L et al.
(
2021
)
.
NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells
.
iScience
vol.
24
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(
7
)
Kranc KR
(
2021
)
.
The essential reading list for AML: the m<sup>6</sup>A transcripts
.
Blood
vol.
138
,
(
1
)
6
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7
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Lawson H, Sepulveda C, van de Lagemaat LN, Durko J, Barile M, Tavosanis A, Georges E, Shmakova A et al.
(
2021
)
.
JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells
.
Blood Advances
vol.
5
,
(
3
)
889
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899
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Mapperley C, Van De Lagemaat L, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J et al.
(
2020
)
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The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function
.
Journal of Experimental Medicine
vol.
218
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(
3
)
20200829
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20200829
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Baumeister J, Chatain N, Hubrich A, Maié T, Costa IG, Denecke B, Han L, Küstermann C et al.
(
2020
)
.
Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms
.
Leukemia
vol.
34
,
(
4
)
1062
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1074
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Luis TC, Lawson H, Kranc KR
(
2020
)
.
Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells
.
Cell Stem Cell
vol.
26
,
(
3
)
299
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301
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Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K et al.
(
2019
)
.
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction
.
Journal of Clinical Investigation
vol.
129
,
(
9
)
3640
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3656
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Menendez-Gonzalez JB, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas LA, Agirre-Lizaso A, Azevedo A et al.
(
2019
)
.
Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia
.
Stem Cell Reports
vol.
13
,
(
2
)
291
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306
.
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al.
(
2019
)
.
Targeting the RNA m<sup>6</sup>A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
.
Cell Stem Cell
vol.
25
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(
1
)
137
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148.e6
.
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.
(
2019
)
.
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR
.
Cell
vol.
177
,
(
5
)
1201
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1216.e19
.
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.
(
2019
)
.
Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018))
.
Cell
vol.
178
,
(
1
)
263
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263
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Van De Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D
(
2018
)
.
CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands 06 Biological Sciences 0601 Biochemistry and Cell Biology 06 Biological Sciences 0604 Genetics
.
Epigenetics and Chromatin
vol.
11
,
(
1
)
Guitart AV, Finch AJ, Kranc KR
(
2018
)
.
Ca<sup>2+</sup>tapulting HSCs into action
.
Journal of Experimental Medicine
vol.
215
,
(
8
)
1971
-
1973
.
Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A et al.
(
2018
)
.
hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
.
Blood
vol.
131
,
(
14
)
1532
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1544
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O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DD, Carragher NO, Kranc KR
(
2018
)
.
Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions
.
Assay and Drug Development Technologies
vol.
16
,
(
1
)
51
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63
.
Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN et al.
(
2017
)
.
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
.
The Journal of experimental medicine
vol.
214
,
(
3
)
719
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735
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Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M et al.
(
2016
)
.
Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability
.
Genes and Development
vol.
30
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(
19
)
2173
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2186
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Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR et al.
(
2016
)
.
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells
.
Autophagy
vol.
12
,
(
6
)
936
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948
.
Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J et al.
(
2016
)
.
Adult hematopoietic stem cells lacking Hif-1α self-renew normally
.
Blood
vol.
127
,
(
23
)
2841
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2846
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Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LEM, Kinstrie R, Guitart AV et al.
(
2016
)
.
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells
.
Blood
vol.
128
,
(
3
)
371
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383
.
Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J et al.
(
2015
)
.
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
.
Journal of Experimental Medicine
vol.
212
,
(
13
)
2223
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2234
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Guitart AV, Vukovic M, Sepulveda C, Panagopoulou T, Allen L, Pollard P, Morton N, Finch A et al.
(
2015
)
.
Dual function of fumarate hydratase in haematopoietic stem cell fates
.
Experimental Hematology
.
vol.
43
,
Kranc KR, Dzierzak E
(
2015
)
.
Relieving oxidative stress in immune cells
.
Journal of Experimental Medicine
vol.
212
,
(
8
)
1140
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1140
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Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Catarina Matias A, Luisa Escapa A, Subramani C, Wheadon H et al.
(
2015
)
.
Acute loss of Cited2 impairs nanog expression and decreases self-renewal of mouse embryonic stem cells
.
Stem Cells
vol.
33
,
(
3
)
699
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712
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Guitart AV, Vukovic M, Sas Z, Vila M, Sepulveda C, Panagopoulou T, Allen L, Pollard P et al.
(
2015
)
.
FUMARATE HYDRATASE IS AN ESSENTIAL REGULATOR OF EMBRYONIC AND ADULT HAEMATOPOIETIC STEM CELL
.
HAEMATOLOGICA
.
vol.
100
,
123
-
123
.
Vukovic M, Guitart AV, Kranc K
(
2015
)
.
HIF-2A IS A TUMOUR SUPPRESSOR IN AML
.
HAEMATOLOGICA
.
vol.
100
,
10
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10
.
Sepulveda C, Guitart A, Vukovic M, Panagopoulou TI, Allen L, Lengelling A, Ratcliffe PJ, Kranc KR
(
2015
)
.
THE ROLE OF 2-OXOGLUTARATE DEPENDENT DIOXYGENASES IN NORMAL HAEMATOPOIESIS AND ACUTE MYELOID LEUKEMIA
.
HAEMATOLOGICA
.
vol.
100
,
9
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9
.
Gezer D, Vukovic M, Soga T, Pollard PJ, Kranc KR
(
2014
)
.
Concise review: Genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells
.
Stem Cells
vol.
32
,
(
6
)
1390
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1397
.
Yang M, Su H, Soga T, Kranc KR, Pollard PJ
(
2014
)
.
Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
.
Hypoxia (Auckl)
vol.
2
,
127
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142
.
Calaminus SDJ, Guitart AV, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM
(
2013
)
.
Correction: Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny (PLoS ONE 7, 12, (e51361) DOI:10.1371/journal.pone.0051361)
.
PLoS ONE
vol.
8
,
(
5
)
Sinclair A, Calaminus S, Pellicano F, Guitart A, Graham S, Poncz M, Graham G, Sansom O et al.
(
2013
)
.
CHEMOKINE SIGNALLING REGULATES HAEMOPOIETIC STEM CELL SURVIVAL
.
HAEMATOLOGICA
.
vol.
98
,
391
-
392
.
Guitart A, Pollard P, Holyoake T, Enver T, Ratcliffe P, Kranc K
(
2013
)
.
HIF-1ALPHA AND HIF-2APLPHA ARE NOT ESSENTIAL FOR STEADY-STATE HEMATOPOIETIC STEM CELL MAINTENANCE
.
HAEMATOLOGICA
.
vol.
98
,
493
-
493
.
Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K et al.
(
2013
)
.
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance
.
Blood
vol.
122
,
(
10
)
1741
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1745
.
Calaminus SDJ, Guitart A, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM
(
2012
)
.
Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny
.
PLoS ONE
vol.
7
,
(
12
)
Sinclair A, Pellicano P, Graham SM, Kinstrie R, Kranc K, Graham G, Holyoake TL
(
2012
)
.
An investigation of the role of CXCL1-CXCR2 signalling in haemopoietic stem cell quiescence
.
BRITISH JOURNAL OF HAEMATOLOGY
.
vol.
157
,
26
-
27
.
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al.
(
2011
)
.
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
.
Journal of Experimental Medicine
vol.
208
,
(
3
)
455
-
467
.
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J et al.
(
2011
)
.
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
.
Journal of Cell Biology
vol.
192
,
(
5
)
i5
-
i5
.
Pollard PJ, Kranc KR
(
2010
)
.
Hypoxia signaling in hematopoietic stem cells: A double-edged sword
.
Cell Stem Cell
vol.
7
,
(
3
)
276
-
278
.
Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, Bouriez-Jones T, Sigvardsson M et al.
(
2009
)
.
Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
.
Cell Stem Cell
vol.
5
,
(
6
)
659
-
665
.
Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al.
(
2009
)
.
T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides (DOI:10.1016/j.immuni.2009.01.009)
.
Immunity
vol.
30
,
(
4
)
Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G et al.
(
2009
)
.
T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides
.
Immunity
vol.
30
,
(
3
)
348
-
357
.
Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI et al.
(
2006
)
.
Functional epistasis on a common MHC haplotype associated with multiple sclerosis
.
Nature
vol.
443
,
(
7111
)
574
-
577
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Kranc KR, Taylor AM, Willcox N, Fugger L
(
2005
)
.
Control of autoimmunity by 'epitope theft'
.
Trends in Molecular Medicine
vol.
11
,
(
1
)
1
-
4
.
Kranc KR, Bamforth SD, Bragança J, Norbury C, Van Lohuizen M, Bhattacharya S
(
2003
)
.
Transcriptional Coactivator Cited2 Induces Bmi1 and Mel18 and Controls Fibroblast Proliferation via Ink4a/ARF
.
Molecular and Cellular Biology
vol.
23
,
(
21
)
7658
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7666
.
HURST HC, Murdoch JN, Eloranta JJ, Braganca J, Bhattacharya S, Henderson DJ, Kranc KR, Marques FIR et al.
(
2001
)
.
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator
.
Nature Genetics
vol.
29
,
(
4
)
469
-
474
.
Clark JF, Pyne GJ, Tao LM, Claridge T, Harris D, Kranc K, Cadoux-Hudson T, Turnbull J et al.
(
2001
)
.
Oxidative degradation of bilirubin produces vasoactive compounds in subarachnoid hemorrhage patients with cerebral vasospasm
.
FASEB JOURNAL
.
vol.
15
,
A112
-
A112
.
Kranc KR, Pyne GJ, Tao L, Claridge TDW, Harris DA, Cadoux-Hudson TAD, Turnbull JJ, Schofield CJ et al.
(
2000
)
.
Oxidative degradation of bilirubin produces vasoactive compounds
.
European Journal of Biochemistry
vol.
267
,
(
24
)
7094
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7101
.
Clark JF, Kranc KR
(
1999
)
.
The role of the mitochondrion in smooth muscle cell fate choices of proliferation versus apoptosis during vascular and cardiovascular diseases
.
Expert Opinion on Therapeutic Targets
vol.
3
,
(
4
)
513
-
525
.