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Publications:  Prof Philip Eaton

Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P(2020). Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth. Redox Biology vol. 29,
10.1016/j.redox.2019.101405
Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO et al.(2020). Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling. Cardiovascular Research vol. 116, (1) 51-62.
10.1093/cvr/cvz202
Abis G, Charles RL, Kopec J, Yue WW, Atkinson RA, Bui TTT, Lynham S, Popova S et al.(2019). 15-deoxy-Δ<sup>12,14</sup>-Prostaglandin J<inf>2</inf> inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism. Communications Biology vol. 2, (1)
10.1038/s42003-019-0426-2
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.(2019). Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase". Circulation vol. 140, (22) E810-E811.
10.1161/CIRCULATIONAHA.119.043869
Csato V, Kadir SZSA, Khavandi K, Bennett H, Sugden S, Gurney AM, Pritchard HT, Hill-Eubanks D et al.(2019). “A Step and a Ceiling”: mechanical properties of Ca<sup>2+</sup> spark vasoregulation in resistance arteries by pressure-induced oxidative activation of PKG. Physiological Reports vol. 7, (22)
10.14814/phy2.14260
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.(2019). Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase. Circulation vol. 140, (2) 126-137.
10.1161/CIRCULATIONAHA.118.037398
Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA et al.(2019). Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. Circulation Research vol. 124, (12) 1727-1746.
10.1161/CIRCRESAHA.118.314284
Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y et al.(2019). Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation. Nature vol. 566, (7745) 548-552.
10.1038/s41586-019-0947-3
Cuello F, Eaton P(2019). Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System.
Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J et al.(2019). PKG1α oxidation negatively regulates food seeking behaviour and reward. Redox Biology vol. 21,
10.1016/j.redox.2018.101077
Abis G, Charles RL, Eaton P, Conte MR(2019). Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain. Protein Expression and Purification vol. 153, 105-113.
10.1016/j.pep.2018.09.001
Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C et al.(2019). Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension. Proceedings of the National Academy of Sciences of the United States of America vol. 116, (26) 13016-13025.
10.1073/pnas.1904064116
Smith J, Schroder E, Prysyazhna O, Cho H, Mayr M, Eaton P (2018). Sulforaphane-mediated inhibition of SHP2 as a potential pharmacotherapy for Noonan syndrome. FREE RADICAL BIOLOGY AND MEDICINE. vol. 128, S42-S42.
10.1016/j.freeradbiomed.2018.10.063
Cuello F, Wittig I, Lorenz K, Eaton P(2018). Oxidation of cardiac myofilament proteins: Priming for dysfunction?. Molecular Aspects of Medicine vol. 63, 47-58.
10.1016/j.mam.2018.08.003
De Nicola GF, Bassi R, Nichols C, Fernandez-Caggiano M, Golforoush PA, Thapa D, Anderson R, Martin ED et al.(2018). The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules. JCI insight vol. 3, (16)
10.1172/jci.insight.121144
Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P(2018). Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. Molecular Cell vol. 69, (3) 438-450.e5.
10.1016/j.molcel.2017.12.019
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65636
Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V et al.(2017). Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity. Scientific Reports vol. 7, (1)
10.1038/s41598-017-09275-1
Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS(2017). Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3. Journal of Biological Chemistry vol. 292, (39) 16161-16173.
10.1074/jbc.M117.785410
Rudyk O, Eaton P(2017). Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity. Free Radical Biology and Medicine vol. 110, 390-398.
10.1016/j.freeradbiomed.2017.07.007
Burgoyne JR, Prysyazhna O, Richards DA, Eaton P(2017). Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG I (Protein Kinase G I). Hypertension vol. 70, (3) 577-586.
10.1161/HYPERTENSIONAHA.117.09670
Wolhuter K, Eaton P(2017). How widespread is stable protein S-nitrosylation as an end-effector of protein regulation?. Free Radical Biology and Medicine vol. 109, 156-166.
10.1016/j.freeradbiomed.2017.02.013
Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G et al.(2017). Distinct regulatory effects of myeloid cell and endothelial cell NAPDH oxidase 2 on blood pressure. Circulation vol. 135, (22) 2163-2177.
10.1161/CIRCULATIONAHA.116.023877
Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I(2017). Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. Redox Biology vol. 11, 176-191.
10.1016/j.redox.2016.12.004
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al.(2016). Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. Nature Communications vol. 7, 13187-13187.
10.1038/ncomms13187
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18949
Khavandi K, Baylie RL, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD et al.(2016). Pressure-induced oxidative activation of PKG enables vasoregulation by Ca<sup>2+</sup> sparks and BK channels. Science Signaling vol. 9, (449)
10.1126/scisignal.aaf6625
Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P(2016). Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation. J Biol Chem vol. 291, (33) 17427-17436.
10.1074/jbc.M116.724070
Fernandez-Caggiano M, Schröder E, Cho HJ, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P(2016). Oxidant-induced interprotein disulfide formation in cardiac protein DJ-1 occurs via an interaction with peroxiredoxin 2. Journal of Biological Chemistry vol. 291, (19) 10399-10410.
10.1074/jbc.M115.699850
Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, Van Velden JD, Buck F et al.(2016). S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEB Journal vol. 30, (5) 1849-1864.
10.1096/fj.201500048
Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E et al.(2016). Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation. Biochemistry vol. 55, (5) 751-761.
10.1021/acs.biochem.5b00774
Mistry RK, Murray TVA, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM et al.(2016). Transcriptional regulation of cystathionine-γ-lyase in endothelial cells by NADPH oxidase 4-dependent signaling. Journal of Biological Chemistry vol. 291, (4) 1774-1788.
10.1074/jbc.M115.685578
Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, Santos RC, López GA, Crespo-Leiro MG, Eaton P, Doménech N(2016). Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue viability. Molecular and Cellular Proteomics vol. 15, (1) 246-255.
10.1074/mcp.M115.051862
Kohl T, Weninger G, Zalk R, Eaton P, Lehnart SE(2015). Intensity matters: Ryanodine receptor regulation during exercise. Proceedings of the National Academy of Sciences of the United States of America vol. 112, (50) 15271-15272.
10.1073/pnas.1521051112
Burgoyne JR, Rudyk O, Cho HJ, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T et al.(2015). Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice. Nature Communications vol. 6,
10.1038/ncomms8920
Eaton P (2015). Thiol redox sensing and signalling and the control of blood pressure. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 47, S6-S7.
10.1016/j.niox.2015.02.013
Cameron JM, Gabrielsen M, Chim YH, Munro J, McGhee EJ, Sumpton D, Eaton P, Anderson KI et al.(2015). Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology vol. 25, (11) 1520-1525.
10.1016/j.cub.2015.04.020
Nakamura T, Ranek MJ, Lee DI, Hahn VS, Kim C, Eaton P, Kass DA(2015). Prevention of PKG1a oxidation augments cardioprotection in the stressed heart. Journal of Clinical Investigation vol. 125, (6) 2468-2472.
10.1172/JCI80275
Prysyazhna O, Eaton P(2015). Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system. Frontiers in Pharmacology vol. 6, (JUN)
10.3389/fphar.2015.00139
Sawa T, Ahmed A, Ono K, Ida T, Fujii S, Eaton P, Akaike T (2014). Persistent activation of protein kinase G by a nitrated cyclic nucleotide via site specific S-guanylation and its implication for vascular hyporeactivity in endotoxin shock. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 42, 140-140.
10.1016/j.niox.2014.09.123
Lorenz JE, Kallenborn-Gerhardt W, Lu R, Syhr KMJ, Eaton P, Geisslinger G, Schmidtko A(2014). Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain after Peripheral Nerve Injury. Antioxidants and Redox Signaling vol. 21, (10) 1504-1515.
10.1089/ars.2013.5585
Islam T, Dantz C, Daniel H, Moellencamp J, El-Armouche A, Eaton P, Maier LS, Wagner S (2014). Disruption of oxidative PKA activation contributes to ventricular remodeling upon increased afterload. EUROPEAN HEART JOURNAL. vol. 35, 330-330.
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al.(2014). Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America vol. 111, (22) 8167-8172.
10.1073/pnas.1402965111
Charles R, Jayawardhana T, Eaton P(2014). Gel-based methods in redox proteomics. Biochimica et Biophysica Acta - General Subjects vol. 1840, (2) 830-837.
10.1016/j.bbagen.2013.04.021
Rudyk O, Eaton P(2014). Biochemical methods for monitoring protein thiol redox states in biological systems. Redox Biology vol. 2, (1) 803-813.
10.1016/j.redox.2014.06.005
Bassi R, Rudyk O, Burgoyne J, Eaton P, Marber MS (2014). CAN REDOX-SENSITIVE CYSTEINES IN P38A-MAPK MODULATE ACTIVATION DURING STRESS?. HEART. vol. 100, A2-A2.
10.1136/heartjnl-2013-305297.3
Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T et al.(2014). Meeting highlights from the 2013 European society of cardiology heart failure association winter meeting on translational heart failure research. European Journal of Heart Failure vol. 16, (1) 6-14.
10.1002/ejhf.10
Eaton P, Shah AM(2014). Preface for redox signalling in the cardiovascular system. Journal of Molecular and Cellular Cardiology vol. 73,
10.1016/j.yjmcc.2014.05.003
Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P(2014). Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfde. Hypertension vol. 64, (6) 1344-1351.
10.1161/HYPERTENSIONAHA.114.04281
Burgoyne JR, Oviosu O, Eaton P(2013). The PEG-switch assay: A fast semi-quantitative method to determine protein reversible cysteine oxidation. Journal of Pharmacological and Toxicological Methods vol. 68, (3) 297-301.
10.1016/j.vascn.2013.07.001
Burgoyne JR, Eaton P(2013). Approaches for monitoring PKG1α oxidative activation. Methods in Molecular Biology vol. 1020, 163-173.
10.1007/978-1-62703-459-3-10
Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P(2013). Protein kinase G oxidation is a major cause of injury during sepsis. Proceedings of the National Academy of Sciences of the United States of America vol. 110, (24) 9909-9913.
10.1073/pnas.1301026110
Burgoyne JR, Oka SI, Ale-Agha N, Eaton P(2013). Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system. Antioxidants and Redox Signaling vol. 18, (9) 1042-1052.
10.1089/ars.2012.4817
Burgoyne JR, Din HM, Eaton P, Shah AM(2013). Response to "Detailed aspects of redox signaling in cardiac physiology and pathology". Circulation research vol. 112, (1)
10.1161/CIRCRESAHA.111.300431
Burgoyne JR, Eaton P(2013). Detecting disulfide-bound complexes and the oxidative regulation of cyclic nucleotide-dependent protein kinases by H<inf>2</inf>O<inf>2</inf>. vol. 528, 111-128.
10.1016/B978-0-12-405881-1.00007-0
Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P(2012). CGMP-dependent activation of protein kinase g precludes disulfide activation: Implications for blood pressure control. Hypertension vol. 60, (5) 1301-1308.
10.1161/HYPERTENSIONAHA.112.198754
Burgoyne JR, Mongue-Din H, Eaton P, Shah AM(2012). Redox signaling in cardiac physiology and pathology. Circulation Research vol. 111, (8) 1091-1106.
10.1161/CIRCRESAHA.111.255216
Zhang M, Takimoto E, Lee DI, Santos CXC, Nakamura T, Hsu S, Jiang A, Nagayama T et al.(2012). Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling. Circulation vol. 126, (8) 942-951.
10.1161/CIRCULATIONAHA.112.090977
Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P(2012). Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse. Circulation vol. 126, (3) 287-295.
10.1161/CIRCULATIONAHA.112.101287
Shao D, Oka SI, Brady CD, Haendeler J, Eaton P, Sadoshima J(2012). Redox modification of cell signaling in the cardiovascular system. Journal of Molecular and Cellular Cardiology vol. 52, (3) 550-558.
10.1016/j.yjmcc.2011.09.009
Prysyazhna O, Rudyk O, Eaton P(2012). Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nature Medicine vol. 18, (2) 286-290.
10.1038/nm.2603
Burgoyne JR, Eaton P(2011). Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation. Biochemical Society Transactions vol. 39, (5) 1260-1267.
10.1042/BST0391260
Akaike T, Vliet AVD, Eaton P(2011). Frontiers in nitric oxide and redox signaling. Nitric Oxide - Biology and Chemistry vol. 25, (2) 57-58.
10.1016/j.niox.2011.05.002
Burgoyne JR, Rudyk O, Mayr M, Eaton P(2011). Nitrosative protein oxidation is modulated during early endotoxemia. Nitric Oxide - Biology and Chemistry vol. 25, (2) 118-124.
10.1016/j.niox.2010.11.005
Ray R, Murdoch CE, Wang M, Santos CX, Zhang M, Alom-Ruiz S, Anilkumar N, Ouattara A et al.(2011). Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31, (6) 1368-1376.
10.1161/ATVBAHA.110.219238
Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD et al.(2011). Redox regulation of soluble epoxide hydrolase by 15-Deoxy-Δ- Prostaglandin J<inf>2</inf> Controls coronary hypoxic vasodilation. Circulation Research vol. 108, (3) 324-334.
10.1161/CIRCRESAHA.110.235879
Maller C, Schröder E, Eaton P(2011). Glyceraldehyde 3-phosphate dehydrogenase is unlikely to mediate hydrogen peroxide signaling: Studies with a novel anti-dimedone sulfenic acid antibody. Antioxidants and Redox Signaling vol. 14, (1) 49-60.
10.1089/ars.2010.3149
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al.(2010). Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. American Journal of Physiology - Heart and Circulatory Physiology vol. 299, (3)
10.1152/ajpheart.00129.2010
Burgoyne JR, Eaton P(2010). Oxidant sensing by protein kinases A and G enables integration of cell redox state with phosphoregulation. Sensors vol. 10, (4) 2731-2751.
10.3390/s100402731
Burgoyne JR, Eaton P(2010). A rapid approach for the detection, quantification, and discovery of novel sulfenic acid or S-nitrosothiol modified proteins using a biotin-switch method. vol. 473,
Burgoyne JR, Eaton P(2009). Transnitrosylating nitric oxide species directly activate type I protein kinase A, providing a novel adenylate cyclase-independent cross-talk to β-adrenergic-like signaling. Journal of Biological Chemistry vol. 284, (43) 29260-29268.
10.1074/jbc.M109.046722
Burgoyne JR, Eaton P(2009). Beating the silent killer: A new way to relax. Biologist vol. 56, (1) 40-45.
Eaton P, Clements-Jewery H(2008). Peroxynitrite: In vivo cardioprotectant or arrhythmogen?. British Journal of Pharmacology vol. 155, (7) 972-973.
10.1038/bjp.2008.372
Schröder E, Brennan JP, Eaton P(2008). Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress. American Journal of Physiology - Heart and Circulatory Physiology vol. 295, (1)
10.1152/ajpheart.00017.2008
Charles RL, Eaton P(2008). Redox signalling in cardiovascular disease. Proteomics - Clinical Applications vol. 2, (6) 823-836.
10.1002/prca.200780104
Schröder E, Eaton P(2008). Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations. Current Opinion in Pharmacology vol. 8, (2) 153-159.
10.1016/j.coph.2007.12.012
Bell JR, Kennington E, Fuller W, Dighe K, Donoghue P, Clark JE, Jia LG, Tucker AL et al.(2008). Characterization of the phospholemman knockout mouse heart: Depressed left ventricular function with increased Na-K-ATPase activity. American Journal of Physiology - Heart and Circulatory Physiology vol. 294, (2)
10.1152/ajpheart.01332.2007
Bell JR, Eaton P, Shattock MJ(2008). Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart. Clinical and Experimental Pharmacology and Physiology vol. 35, (2) 126-134.
10.1111/j.1440-1681.2007.04794.x
Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P(2007). Cysteine redox sensor in PKGIα enables oxidant-induced activation. Science vol. 317, (5843) 1393-1397.
10.1126/science.1144318
Charles RL, Schröder E, May G, Free P, Gaffney PRJ, Wait R, Begum S, Heads RJ et al.(2007). Protein sulfenation as a redox sensor: Proteomics studies using a novel biotinylated dimedone analogue. Molecular and Cellular Proteomics vol. 6, (9) 1473-1484.
10.1074/mcp.M700065-MCP200
Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schröder E, Wait R, Begum S, Kentish JC et al.(2006). Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. Journal of Biological Chemistry vol. 281, (31) 21827-21836.
10.1074/jbc.M603952200
Brennan JP, Eaton P(2006). Oxidized Proteins in Cardiac Ischemia and Reperfusion. Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases,
Eaton P(2006). Protein thiol oxidation in health and disease: Techniques for measuring disulfides and related modifications in complex protein mixtures. Free Radical Biology and Medicine vol. 40, (11) 1889-1899.
10.1016/j.freeradbiomed.2005.12.037
Brennan JP, Miller JIA, Fuller W, Wait R, Begum S, Dunn MJ, Eaton P(2006). The utility of N,N-biotinyl glutathione disulfide in the study of protein S-glutathiolation. Molecular and Cellular Proteomics vol. 5, (2) 215-225.
10.1074/mcp.M500212-MCP200
Eaton P, Bell RM, Cave AC, Shattock MJ(2005). Ischemic preconditioning: A potential role for protein S-thiolation?. Antioxidants and Redox Signaling vol. 7, (7-8) 882-888.
10.1089/ars.2005.7.882
Eaton P, Shattock MJ(2005). Protein S-thiolation: Emphasis on cell signaling and gene expression. Antioxidants and Redox Signaling vol. 7, (7-8) 839-840.
10.1089/ars.2005.7.839
Silverman BDZ, Fuller W, Eaton P, Deng J, Moorman JR, Cheung JY, James AF, Shattock MJ(2005). Serine 68 phosphorylation of phospholemman: Acute isoform-specific activation of cardiac Na/K ATPase. Cardiovascular Research vol. 65, (1) 93-103.
10.1016/j.cardiores.2004.09.005
Saurin AT, Neubert H, Brennan JP, Eaton P(2004). Widespread sulfenic acid formation in tissues in response to hydrogen peroxide. Proceedings of the National Academy of Sciences of the United States of America vol. 101, (52) 17982-17987.
10.1073/pnas.0404762101
Brennan JP, Wait R, Begum S, Bell JR, Dunn MJ, Eaton P(2004). Detection and mapping of widespread intermolecular protein disulfide formation during cardiac oxidative stress using proteomics with diagonal electrophoresis. Journal of Biological Chemistry vol. 279, (40) 41352-41360.
10.1074/jbc.M403827200
Fuller W, Eaton P, Bell JR, Shattock MJ(2004). Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 18, (1) 197-199.
10.1096/fj.03-0213fje
Fuller W, Parmar V, Eaton P, Bell JR, Shattock MJ(2003). Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress. Cardiovascular Research vol. 57, (4) 1044-1051.
10.1016/S0008-6363(02)00810-6
LEUNG K, Shattock MJ, Pratt JR, Ward MA, Byers HL, Leeds N, McGregor E, Eaton P et al. (2003). Reversible cysteine-targeted oxidation of proteins during renal oxidative stress. J Am Soc Nephrol. vol. 3, S290-296.
10.1097/01.asn.0000078024.50060.c6
Eaton P, Wright N, Hearse DJ, Shattock MJ(2002). Glyceraldehyde phosphate dehydrogenase oxidation during cardiac ischemia and reperfusion. Journal of Molecular and Cellular Cardiology vol. 34, (11) 1549-1560.
10.1006/jmcc.2002.2108
Eaton P, Fuller W, Shattock MJ(2002). S-Thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation. Journal of Biological Chemistry vol. 277, (24) 21189-21196.
10.1074/jbc.M200591200
Eaton P, Byers HL, Leeds N, Ward MA, Shattock MJ(2002). Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion. Journal of Biological Chemistry vol. 277, (12) 9806-9811.
10.1074/jbc.M111454200
Eaton P, Shattock MJ (2002). Purification of proteins susceptible to oxidation at cysteine residues: Identification of malate dehydrogenase as a target for S-glutathiolation. Annals of the New York Academy of Sciences. vol. 973, 529-532.
10.1111/j.1749-6632.2002.tb04694.x
Eaton P, Hearse DJ, Shattock MJ(2001). Lipid hydroperoxide modification of proteins during myocardial ischaemia. Cardiovascular Research vol. 51, (2) 294-303.
10.1016/S0008-6363(01)00303-0
Fuller W, Eaton P, Medina RA, Bell J, Shattock MJ(2001). Differential centrifugation separates cardiac sarcolemmal and endosomal membranes from langendorff-perfused rat hearts. Analytical Biochemistry vol. 293, (2) 216-223.
10.1006/abio.2001.5127
Eaton P, Fuller W, Bell JR, Shattock MJ(2001). αB crystallin translocation and phosphorylation: Signal transduction pathways and preconditioning in the isolated rat heart. Journal of Molecular and Cellular Cardiology vol. 33, (9) 1659-1671.
10.1006/jmcc.2001.1418
Eaton P, Awad WI, Miller JI, Hearse DJ, Shattock MJ(2000). Ischemic preconditioning: A potential role for constitutive low molecular weight stress protein translocation and phosphorylation?. Journal of Molecular and Cellular Cardiology vol. 32, (6) 961-971.
10.1006/jmcc.2000.1136
Eaton P, Li JM, Hearse DJ, Shattock MJ(1999). Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. American Journal of Physiology - Heart and Circulatory Physiology vol. 276, (3 45-3)
10.1152/ajpheart.1999.276.3.h935
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