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Publications:  Dr Oleksandra Prysyazhna

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO et al.(2020). Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling. Cardiovascular Research vol. 116, (1) 51-62.
10.1093/cvr/cvz202
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.(2019). Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase". Circulation vol. 140, (22) E810-E811.
10.1161/CIRCULATIONAHA.119.043869
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.(2019). Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase. Circulation vol. 140, (2) 126-137.
10.1161/CIRCULATIONAHA.118.037398
Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y et al.(2019). Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation. Nature vol. 566, (7745) 548-552.
10.1038/s41586-019-0947-3
Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J et al.(2019). PKG1α oxidation negatively regulates food seeking behaviour and reward. Redox Biology vol. 21,
10.1016/j.redox.2018.101077
Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C et al.(2019). Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension. Proceedings of the National Academy of Sciences of the United States of America vol. 116, (26) 13016-13025.
10.1073/pnas.1904064116
Smith J, Schroder E, Prysyazhna O, Cho H, Mayr M, Eaton P (2018). Sulforaphane-mediated inhibition of SHP2 as a potential pharmacotherapy for Noonan syndrome. FREE RADICAL BIOLOGY AND MEDICINE. vol. 128, S42-S42.
10.1016/j.freeradbiomed.2018.10.063
Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V et al.(2017). Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity. Scientific Reports vol. 7, (1)
10.1038/s41598-017-09275-1
Burgoyne JR, Prysyazhna O, Richards DA, Eaton P(2017). Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG I (Protein Kinase G I). Hypertension vol. 70, (3) 577-586.
10.1161/HYPERTENSIONAHA.117.09670
Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G et al.(2017). Distinct regulatory effects of myeloid cell and endothelial cell NAPDH oxidase 2 on blood pressure. Circulation vol. 135, (22) 2163-2177.
10.1161/CIRCULATIONAHA.116.023877
Prysyazhna O, Scotcher J, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. (2016). Redox Control of Protein Kinase G I alpha Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation. FREE RADICAL BIOLOGY AND MEDICINE. vol. 100, S148-S148.
10.1016/j.freeradbiomed.2016.10.389
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al.(2016). Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. Nature Communications vol. 7, 13187-13187.
10.1038/ncomms13187
https://qmro.qmul.ac.uk/xmlui/handle/123456789/18949
Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P(2016). Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation. J Biol Chem vol. 291, (33) 17427-17436.
10.1074/jbc.M116.724070
Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E et al.(2016). Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation. Biochemistry vol. 55, (5) 751-761.
10.1021/acs.biochem.5b00774
Mistry RK, Murray TVA, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM et al.(2016). Transcriptional regulation of cystathionine-γ-lyase in endothelial cells by NADPH oxidase 4-dependent signaling. Journal of Biological Chemistry vol. 291, (4) 1774-1788.
10.1074/jbc.M115.685578
Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, Santos RC, López GA, Crespo-Leiro MG, Eaton P, Doménech N(2016). Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue viability. Molecular and Cellular Proteomics vol. 15, (1) 246-255.
10.1074/mcp.M115.051862
Burgoyne JR, Rudyk O, Cho HJ, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T et al.(2015). Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice. Nature Communications vol. 6,
10.1038/ncomms8920
Prysyazhna O, Eaton P(2015). Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system. Frontiers in Pharmacology vol. 6, (JUN)
10.3389/fphar.2015.00139
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al.(2014). Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America vol. 111, (22) 8167-8172.
10.1073/pnas.1402965111
Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P(2014). Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfde. Hypertension vol. 64, (6) 1344-1351.
10.1161/HYPERTENSIONAHA.114.04281
Prysyazhna O, Burgoyne JR, Eaton PP (2013). Cys42Ser PKG I alpha Mutant Mice Are Protected from Doxorubicin-Induced Cardiomyopathy. FREE RADICAL BIOLOGY AND MEDICINE. vol. 65, S80-S81.
10.1016/j.freeradbiomed.2013.10.586
Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P (2013). Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy. FREE RADICAL BIOLOGY AND MEDICINE. vol. 65, S69-S69.
10.1016/j.freeradbiomed.2013.10.554
Burgoyne JR, Rudyk O, Prysyazhna O, Schroeder K, Brandes RP, Shah AM, Eaton P (2013). Oxidation of Camp Dependent Protein Kinase Regulator RI alpha Mediates Angiogenesis. FREE RADICAL BIOLOGY AND MEDICINE. vol. 65, S68-S68.
10.1016/j.freeradbiomed.2013.10.551
Rudyk O, Prysyazhna O, Eaton P (2013). Redox-Dead Protein Kinase a RI alpha knock-in Mouse Is Not Hypertensive But Has Increased Vascular Reactivity to Oxidants. FREE RADICAL BIOLOGY AND MEDICINE. vol. 65, S82-S82.
10.1016/j.freeradbiomed.2013.10.590
Stubbert D, Prysyazhna O, Rudyk O, Burgoyne JR, Eaton P (2013). The Blood Pressure-Lowering Action of the Reductant Hydrogen Sulfide Is Paradoxically Mediated by the Oxidative Activation of Protein Kinase G I alpha. FREE RADICAL BIOLOGY AND MEDICINE. vol. 65, S84-S84.
10.1016/j.freeradbiomed.2013.10.595
Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P(2013). Protein kinase G oxidation is a major cause of injury during sepsis. Proceedings of the National Academy of Sciences of the United States of America vol. 110, (24) 9909-9913.
10.1073/pnas.1301026110
Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P(2012). CGMP-dependent activation of protein kinase g precludes disulfide activation: Implications for blood pressure control. Hypertension vol. 60, (5) 1301-1308.
10.1161/HYPERTENSIONAHA.112.198754
Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P (2012). Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption. FREE RADICAL BIOLOGY AND MEDICINE. vol. 53, S174-S174.
10.1016/j.freeradbiomed.2012.10.479
Prysyazhna O, Cuellou F, Eaton P (2012). Impaired Diastolic Relaxation in Cys42Ser PKGIalpha Mutant Mice. FREE RADICAL BIOLOGY AND MEDICINE. vol. 53, S172-S172.
10.1016/j.freeradbiomed.2012.10.474
Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P (2012). cGMP Impedes Disulfide Activation of Protein Kinase G: Implications in Blood Pressure Regulation. FREE RADICAL BIOLOGY AND MEDICINE. vol. 53, S156-S156.
10.1016/j.freeradbiomed.2012.10.425
Burgoyne JR, Prysyazhna O, Eaton P (2012). Dynamic interplay between classical and oxidative activation of PKG1 alpha - implications for blood pressure control. FREE RADICAL BIOLOGY AND MEDICINE. vol. 53, S129-S130.
10.1016/j.freeradbiomed.2012.08.271
Rudyk O, Prysyazhna O, Eaton P (2012). Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1 alpha knock-in mouse. FREE RADICAL BIOLOGY AND MEDICINE. vol. 53, S138-S138.
10.1016/j.freeradbiomed.2012.08.288
Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P(2012). Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse. Circulation vol. 126, (3) 287-295.
10.1161/CIRCULATIONAHA.112.101287
Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P (2012). Loss of nitroglycerin-induced blood pressure lowering in redox-dead Cys42Ser PKG1 alpha knock-in mouse. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. vol. 27, S13-S14.
10.1016/j.niox.2012.04.049
Prysyazhna O, Rudyk O, Eaton P(2012). Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nature Medicine vol. 18, (2) 286-290.
10.1038/nm.2603
Prysyazhna O, Rudyk O, Eaton P (2012). ATTENUATED EDHF-RESPONSE UNDERLIES HYPERTENSION IN REDOX-DEAD CYS42SER PKGI alpha KNOCK-IN MOUSE. JOURNAL OF VASCULAR RESEARCH. vol. 49, 39-39.
Prysyazhna O, Rudyk O, Eaton P (2011). Cys42Ser Substitution in Murine Protein Kinase G1alpha Eliminates Oxidant Sensing To Cause Hypertension. FREE RADICAL BIOLOGY AND MEDICINE. vol. 51, S49-S49.
10.1016/j.freeradbiomed.2011.10.124
Rudyk O, Prysyazhna O, Burgoyne J, Eaton P (2011). Oxidation-Induced Activation of PKG 1alpha Contributes To Nitroglycerin-Induced Vasorelaxation. FREE RADICAL BIOLOGY AND MEDICINE. vol. 51, S50-S50.
10.1016/j.freeradbiomed.2011.10.128
Korkach JP, Dudchenko NO, Kotsuruba AV, Prysyazhna OD, Sagach VF(2008). Role of non-haem iron in protecting effect of ecdysterone on development of streptozotocine-induced hyperglycaemia in rats. Ukrain'skyi Biokhimichnyi Zhurnal vol. 80, (1) 46-51.
Prysyazhna OD, Sagach VF (2007). UCP blockade decreases disturbances of contractive reactions of heart and vessels with type 1 experimental diabetes mellitus. DIABETOLOGIA. vol. 50, S91-S91.
Prysyazhna OD, Sagach VF (2006). Infringement of NO-dependent regulation of contractive reactions of heart and vessels at experimental diabetes mellitus. JOURNAL OF VASCULAR RESEARCH. vol. 43, 556-556.
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