Publications: Dr Oleksandra Prysyazhna

Yogendran V, Mele L, Prysyazhna O, Budhram-Mahadeo VS ( 2023 ) . Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways . Cell Death & Disease vol. 14 , ( 11 )

Caggiano MF, Charles R, Prysyazhna O, Eaton P ( 2023 ) . UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2 . Free Radical Biology and Medicine vol. 208 ,

Kanai M, Andrews SJ, Cordioli M, Stevens C, Neale BM, Daly M, Ganna A, Chwialkowska K et al. ( 2023 ) . A second update on mapping the human genetic architecture of COVID-19 . Nature vol. 621 , ( 7977 ) e7 - e26 .

Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M et al. ( 2023 ) . Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (Nature, (2023), 617, 7962, (764-768), 10.1038/s41586-023-06034-3) . Nature vol. 619 , ( 7971 ) E61 - E61 .

Rudyk O, Prysyazhna O, Eaton P ( 2023 ) . BS17 Oxidation of protein kinase a regulatory subunit PKARIα alpha regulates vasodilation and blood pressure lowering . Conference: Basic Sciencea257 - a258 .

Clohisey S, Millar J, Shankar-Hari M, Aitkin E, Aravindan L, Armstrong R, Baillie JK, Biggs H et al. ( 2023 ) . GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 . Nature vol. 617 , ( 7962 ) 764 - 768 .

Baillie JK, Begg C, Clohisey Hendry S, Hinds C, Horby P, Knight J, Ling L, Maslove D et al. ( 2022 ) . Whole-genome sequencing reveals host factors underlying critical COVID-19 . Nature vol. 607 , ( 7917 ) 97 - 103 .

Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S et al. ( 2021 ) . Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity . Human Genetics vol. 141 , ( 1 ) 147 - 173 .

Niemi MEK, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Davis L, Lee S et al. ( 2021 ) . Mapping the human genetic architecture of COVID-19 . Nature vol. 600 , ( 7889 ) 472 - 477 .

Boguslavskyi A, Tokar S, Prysyazhna O, Rudyk O, Sanchez-Tatay D, Lemmey HAL, Dora KA, Garland CJ et al. ( 2020 ) . Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans . Circulation vol. 143 , ( 11 ) 1123 - 1138 .

Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N et al. ( 2020 ) . Genetic mechanisms of critical illness in COVID-19 . Nature vol. 591 , ( 7848 ) 92 - 98 .

Fernandez-Caggiano M, Kamynina A, Francois AA, Prysyazhna O, Eykyn TR, Krasemann S, Crespo-Leiro MG, Vieites MG et al. ( 2020 ) . Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy . Nature Metabolism vol. 2 , ( 11 ) 1223 - 1231 .

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Response by Prysyazhna et al to Letter Regarding Article, “Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase” . Circulation vol. 140 , ( 22 ) e810 - e811 .

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO et al. ( 2019 ) . Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling . Cardiovascular Research vol. 116 , ( 1 ) 51 - 62 .

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C et al. ( 2019 ) . Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension . Proceedings of the National Academy of Sciences of the United States of America vol. 116 , ( 26 ) 13016 - 13025 .

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al. ( 2019 ) . Blood Pressure-Lowering by the Antioxidant Resveratrol is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase . Circulation vol. 140 , ( 2 ) 126 - 137 .

Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y et al. ( 2019 ) . Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation . Nature vol. 566 , ( 7745 ) 548 - 552 .

Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J et al. ( 2018 ) . PKG1α oxidation negatively regulates food seeking behaviour and reward . Redox Biology vol. 21 ,

Smith J, Schroder E, Prysyazhna O, Cho H, Mayr M, Eaton P ( 2018 ) . 61 Sulforaphane-mediated inhibition of SHP2 as a potential pharmacotherapy for Noonan syndrome . Free Radical Biology and Medicine . vol. 128 ,

Kapil V ( 2017 ) . Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017 . BMC Pharmacol Toxicol vol. 18 , ( Suppl 1 ) 64 - 64 .

Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V et al. ( 2017 ) . Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity . Scientific Reports vol. 7 , ( 1 )

Burgoyne JR, Prysyazhna O, Richards DA, Eaton P ( 2017 ) . Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG I&agr; (Protein Kinase G I&agr;) . Hypertension vol. 70 , ( 3 ) 577 - 586 .

Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G et al. ( 2017 ) . Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure . Circulation vol. 135 , ( 22 ) 2163 - 2177 .

Goetz M, Donzelli S, Schmidt K, Wolters M, Stathopoulou K, Prysyazhna O, Scotcher J, Dees C et al. ( 2017 ) . Nitroxyl mediates vasodilation by inducing an activating intradisulfide bond in the high affinity cGMP-binding site of PKGIα . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 38 - 38 .

Rudyk O, Krasemann S, Hartmann K, Prysyazhna O, Zhang M, Weiss A, Zhao L, Schermuly R et al. ( 2017 ) . PKGIα oxidation during chronic hypoxia provides an adaptive vasodilatory mechanism that limits pulmonary hypertension . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 9 - 9 .

Schulz S, Prysyazhna O, Eaton P, Cuello F ( 2017 ) . Revealing transcriptomic changes in response to chronic angiotensin II infusion in atria versus ventricles of the mouse by nanostring analysis . JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY . vol. 109 , 25 - 26 .

Prysyazhna O, Scotcher J, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. ( 2016 ) . 348 Redox Control of Protein Kinase G Iα Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation . Free Radical Biology and Medicine . vol. 100 ,

Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al. ( 2016 ) . Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response . Nature Communications vol. 7 , 13187 - 13187 .

Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P ( 2016 ) . Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation . J Biol Chem vol. 291 , ( 33 ) 17427 - 17436 .

Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E et al. ( 2016 ) . Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S‑Guanylation . Biochemistry vol. 55 , ( 5 ) 751 - 761 .

Mistry RK, Murray TVA, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM et al. ( 2015 ) . Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling* . Journal of Biological Chemistry vol. 291 , ( 4 ) 1774 - 1788 .

Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, CalviñoSantos R, Aldama López G, Generosa Crespo-Leiro M, Eaton P, Doménech N ( 2015 ) . Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability* . Molecular & Cellular Proteomics vol. 15 , ( 1 ) 246 - 255 .

Rudyk O, Prysyazhna O, Zhao L, Eaton P ( 2015 ) . Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension . BMC Pharmacology and Toxicology vol. 16 , ( Suppl 1 )

Prysyazhna O, Burgoyne JR, Eaton P ( 2015 ) . Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation . BMC Pharmacology and Toxicology vol. 16 , ( Suppl 1 )

Burgoyne JR, Rudyk O, Cho H-J, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T et al. ( 2015 ) . Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice . Nature Communications vol. 6 , ( 1 )

Prysyazhna O, Eaton P ( 2015 ) . Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system . Frontiers in Pharmacology vol. 6 ,

Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P ( 2014 ) . Protein Kinase G I&agr; Oxidation Paradoxically Underlies Blood Pressure Lowering by the Reductant Hydrogen Sulfide . Hypertension vol. 64 , ( 6 ) 1344 - 1351 .

Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA et al. ( 2014 ) . Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase . Proceedings of the National Academy of Sciences of the United States of America vol. 111 , ( 22 ) 8167 - 8172 .

Burgoyne JR, Rudyk O, Prysyazhna O, Schröder K, Brandes RP, Shah AM, Eaton P ( 2013 ) . PSS132 Oxidation of Camp Dependent Protein Kinase Regulatory RIα Mediates Angiogenesis . Free Radical Biology and Medicine . vol. 65 ,

Charles RL, Rudyk O, Prysyazhna O, Yang J, Morisseau C, Hammock B, Freeman B, Eaton P ( 2013 ) . PSS135 Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy . Free Radical Biology and Medicine . vol. 65 ,

Prysyazhna O, Burgoyne JR, Eaton PP ( 2013 ) . PSS167 Cys42Ser PKG Iα Mutant Mice Are Protected from Doxorubicin-Induced Cardiomyopathy . Free Radical Biology and Medicine . vol. 65 , s80 - s81 .

Rudyk O, Prysyazhna O, Eaton P ( 2013 ) . PSS171 Redox-Dead Protein Kinase a RIα knock-in Mouse Is Not Hypertensive But Has Increased Vascular Reactivity to Oxidants . Free Radical Biology and Medicine . vol. 65 ,

Stubbert D, Prysyazhna O, Rudyk O, Burgoyne JR, Eaton P ( 2013 ) . PSS176 The Blood Pressure-Lowering Action of the Reductant Hydrogen Sulfide Is Paradoxically Mediated by the Oxidative Activation of Protein Kinase G Iα . Free Radical Biology and Medicine . vol. 65 ,

Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar R, Eaton P ( 2013 ) . Protein kinase G oxidation contribute to hypotension and organ injury during sepsis . BMC Pharmacology and Toxicology vol. 14 , ( Suppl 1 )

Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P ( 2013 ) . Protein kinase G oxidation is a major cause of injury during sepsis . Proceedings of the National Academy of Sciences of the United States of America vol. 110 , ( 24 ) 9909 - 9913 .

Schroder E, Prysyazhna O, Charles R, Burgoyne J, Eaton P ( 2012 ) . Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption . Free Radical Biology and Medicine . vol. 53 ,

Prysyazhna O, Cuello F, Eaton P ( 2012 ) . Impaired Diastolic Relaxation in Cys42Ser PKGIalpha Mutant Mice . Free Radical Biology and Medicine . vol. 53 ,

Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . cGMP Impedes Disulfide Activation of Protein Kinase G: Implications in Blood Pressure Regulation . Free Radical Biology and Medicine . vol. 53 ,

Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation . Hypertension vol. 60 , ( 5 ) 1301 - 1308 .

Burgoyne⁎ JR, Prysyazhna O, Eaton P ( 2012 ) . Dynamic interplay between classical and oxidative activation of PKG1α - implications for blood pressure control . Free Radical Biology and Medicine . vol. 53 , s129 - s130 .

Rudyk⁎ O, Prysyazhna O, Eaton P ( 2012 ) . Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse . Free Radical Biology and Medicine . vol. 53 ,

Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P ( 2012 ) . Loss of nitroglycerin-induced blood pressure lowering in redox-dead Cys42Ser PKG1α knock-in mouse . Nitric Oxide . vol. 27 , s13 - s14 .

Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P ( 2012 ) . Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1&agr; Knock-In Mouse . Circulation vol. 126 , ( 3 ) 287 - 295 .

Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension . Nature Medicine vol. 18 , ( 2 ) 286 - 290 .

Prysyazhna O, Rudyk O, Eaton P ( 2012 ) . ATTENUATED EDHF-RESPONSE UNDERLIES HYPERTENSION IN REDOX-DEAD CYS42SER PKGIα KNOCK-IN MOUSE . JOURNAL OF VASCULAR RESEARCH . vol. 49 , 39 - 39 .

Prysyazhna O, Rudyk O, Eaton P ( 2011 ) . Cys42Ser Substitution in Murine Protein Kinase G1alpha Eliminates Oxidant Sensing To Cause Hypertension . Free Radical Biology and Medicine . vol. 51 ,

Rudyk O, Prysyazhna O, Burgoyne J, Eaton P ( 2011 ) . Oxidation-Induced Activation of PKG 1alpha Contributes To Nitroglycerin-Induced Vasorelaxation . Free Radical Biology and Medicine . vol. 51 ,

Prysyazhna O, Rudyk O, Eaton P ( 2011 ) . High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIα knock-in mouse . BMC Pharmacology vol. 11 , ( Suppl 1 )

Korkach IP, Dudchenko NO, Kotsiuruba AV, Prysiazhna OD, Sahach VF ( 2008 ) . [Role of non-haem iron in protecting effect of ecdysterone on development of streptozocin-induced hyperglycaemia in rats] . The Ukrainian Biochemical Journal vol. 80 , ( 1 ) 46 - 51 .

Sahach VF, Korkach IP, Kotsiuruba AV, Prysiazhna OD ( 2008 ) . [The inhibition of oxidative and nitrosative stresses by ecdysterone as the mechanisms of its cardio- and vasoprotective action in experimental diabetes type I] . Fiziolohichnyĭ Zhurnal vol. 54 , ( 5 ) 46 - 54 .

Prysiazhna OD, Sahach VF ( 2008 ) . [The role of mitochondrial uncoupling proteins in the development of changes of endothelium-dependent reactions of the heart and vessels in experimental diabetes mellitus] . Fiziolohichnyĭ Zhurnal vol. 54 , ( 1 ) 10 - 16 .

Prysyazhna OD, Sagach VF ( 2007 ) . The role of oxidative stress in the development of myocardial diastolic dysfunction with diabetes mellitus . Journal of Molecular and Cellular Cardiology vol. 42 , ( 6 )

Prysyazhna OD, Sagach VF ( 2007 ) . UCP blockade decreases disturbances of contractive reactions of heart and vessels with type 1 experimental diabetes mellitus . DIABETOLOGIA . vol. 50 , S91 - S91 .

Prysiazhna OD, Kotsiuruba AV, Tkachenko MM, Sahach VV ( 2007 ) . [Effect of enalapril on endotheliun-dependent contractile reactions and oxygen cost of work of the smooth muscles in experimental diabetes mellitus] . Fiziolohichnyĭ Zhurnal vol. 53 , ( 1 ) 3 - 10 .

Korkach IP, Kotsiuruba AV, Prysiazhna OD, Mohyl'nyts'ka LD, Sahach VF ( 2007 ) . [NO-dependent mechanisms of ecdysterone protective action on the heart and vessels in streptozotocin-induced diabetes mellitus in rats] . Fiziolohichnyĭ Zhurnal vol. 53 , ( 3 ) 3 - 8 .

Prysiazhna OD, Kotsiuruba AV, Talanov SO, Sahach VF ( 2007 ) . [Normalizing effect of intermittent hypoxic training on the function of endothelium in experimental diabetes mellitus] . Fiziolohichnyĭ Zhurnal vol. 53 , ( 2 ) 3 - 7 .

Korkach IP, Rudyk OV, Kotsiuruba AV, Prysiazhna OD, Sahach VF ( 2007 ) . [The role of nitric oxide and superoxide synthesis in protective mechanism of ecdysterone in the heart mitochondria of rats with streptozotocin-induced diabetes] . Fiziolohichnyĭ Zhurnal vol. 53 , ( 5 ) 22 - 28 .

Sagach VF, Prysyazhna OD ( 2006 ) . Myocardial diastolic dysfunction at experimental diabetes mellitus—the role of nitric oxide . Journal of Molecular and Cellular Cardiology vol. 40 , ( 6 )

Prysyazhna OD, Sagach VF ( 2006 ) . Infringement of NO-dependent regulation of contractive reactions of heart and vessels at experimental diabetes mellitus . JOURNAL OF VASCULAR RESEARCH . vol. 43 , 556 - 556 .

Prysiazhna OD, Kotsiuruba AV, Tkachenko MM, Sahach VF ( 2006 ) . [Mechanisms of contractile reaction changes and efficiency of oxygen utilization by portal vein smooth muscles in experimental diabetes mellitus] . Fiziolohichnyĭ Zhurnal vol. 52 , ( 1 ) 8 - 16 .

Sahach VF, Prysiazhna OD, Tkachenko MN, Kotsiuruba AV ( 2005 ) . [Effect of L-arginine on the endothelium functional activity in experimental diabetes mellitus] . Fiziolohichnyĭ Zhurnal vol. 51 , ( 2 ) 3 - 7 .

Bondarenko OI, Prysiazhna OD, Sahach VF ( 2004 ) . Electrical responses of intact aortic endothelium in rats with experimental diabetes . Fiziolohichnyĭ Zhurnal vol. 50 , ( 6 ) 3 - 8 .

Prysyazhna OD, Sagach VF, Kotsyuruba AV, Tkachenko MN ( 2003 ) . Endothelium-Dependent Stretch-Induced Contractile Responses of Vascular Smooth Muscles in Experimental Diabetes Mellitus, and the Nitric Oxide System . Neurophysiology vol. 35 , ( 3-4 ) 339 - 339 .

Sahach VF, Tkachenko MM, Prysiazhna OD, Kotsiuruba AV, Mehed' OF ( 2003 ) . Changes in vasodilator responses of vascular smooth muscles and nitric oxide system in experimental diabetes mellitus . Fiziolohichnyĭ Zhurnal vol. 49 , ( 4 ) 24 - 32 .