Publications:  Dr Michele Orini

Campos FO, Orini M, Taggart P, Hanson B, Lambiase PD, Porter B, Rinaldi CA, Gill J et al.(2019). Characterizing the clinical implementation of a novel activation-repolarization metric to identify targets for catheter ablation of ventricular tachycardias using computational models. Comput Biol Med vol. 108, 263-275.

van Duijvenboden S, Hanson B, Child N, Lambiase PD, Rinaldi CA, Jaswinder G, Taggart P, Orini M(2019). Pulse Arrival Time and Pulse Interval as Accurate Markers to Detect Mechanical Alternans. Ann Biomed Eng vol. 47, (5) 1291-1299.

Srinivasan NT, Orini M, Providencia R, Dhinoja MB, Lowe MD, Ahsan SY, Chow AW, Hunter RJ et al.(2019). Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation. Europace vol. 21, (4) 616-625.

Graham AJ, Orini M, Zacur E, Dhillon G, Daw H, Srinivasan NT, Lane JD, Cambridge A et al.(2019). Simultaneous Comparison of Electrocardiographic Imaging and Epicardial Contact Mapping in Structural Heart Disease. Circ Arrhythm Electrophysiol vol. 12, (4)

Honarbakhsh S, Schilling RJ, Orini M, Providencia R, Finlay M, Keating E, Lambiase PD, Chow A et al.(2019). Left atrial scarring and conduction velocity dynamics: Rate dependent conduction slowing predicts sites of localized reentrant atrial tachycardias. Int J Cardiol vol. 278, 114-119.

Orini M, Yanni J, Taggart P, Hanson B, Hayward M, Smith A, Zhang H, Colman M et al.(2019). Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart. Europace

Valderas Yamuza MT, Bolea J, Orini M, Laguna P, Orrite C, Vallverdu M, Bailon R(2019). Human emotion characterization by heart rate variability analysis guided by respiration. IEEE J Biomed Health Inform

Lázaro J, Gil E, Orini M, Laguna P, Bailón R(2019). Baroreflex Sensitivity Measured by Pulse Photoplethysmography. Front Neurosci vol. 13,

Honarbakhsh S, Schilling RJ, Orini M, Providencia R, Keating E, Finlay M, Sporton S, Chow A et al.(2019). Structural remodeling and conduction velocity dynamics in the human left atrium: Relationship with reentrant mechanisms sustaining atrial fibrillation. Heart Rhythm vol. 16, (1) 18-25.

Srinivasan NT, Orini M, Providencia R, Simon R, Lowe M, Segal OR, Chow AW, Schilling RJ et al.(2018). Differences in the upslope of the precordial body surface ECG T wave reflect right to left dispersion of repolarization in the intact human heart. Heart Rhythm

Besleaga T, Badiani S, Lloyd G, Toschi N, Canichella A, Demosthenous A, Lambiase PD, Orini M(2018). Non-Invasive Detection of Mechanical Alternans Utilizing Photoplethysmography. IEEE J Biomed Health Inform

Martin CA, Orini M, Srinivasan NT, Bhar-Amato J, Honarbakhsh S, Chow AW, Lowe MD, Ben-Simon R et al.(2018). Assessment of a conduction-repolarisation metric to predict Arrhythmogenesis in right ventricular disorders. Int J Cardiol vol. 271, 75-80.

Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M et al.(2018). Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1). Circ Arrhythm Electrophysiol vol. 11, (10) e006740-e006740.

Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA et al.(2018). Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome. Circ Arrhythm Electrophysiol vol. 11, (9) e006330-e006330.

Pueyo E, Orini M, Rodríguez JF, Taggart P(2018). Corrigendum to "Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans" [J. Mol. Cell. Cardiol. 97 (2016) 93-105]. J Mol Cell Cardiol vol. 121,

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al.(2018). Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biol vol. 19, (1)

Orini M, Pueyo E, Laguna P, Bailon R(2018). A Time-Varying Nonparametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability. IEEE Trans Biomed Eng vol. 65, (7) 1443-1451.

Orini M, Taggart P, Lambiase PD(2018). In vivo human sock-mapping validation of a simple model that explains unipolar electrogram morphology in relation to conduction-repolarization dynamics. J Cardiovasc Electrophysiol vol. 29, (7) 990-997.

Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al.(2018). Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system. Nat Commun vol. 9, (1)

Valenza G, Faes L, Citi L, Orini M, Barbieri R(2018). Instantaneous Transfer Entropy for the Study of Cardiovascular and Cardiorespiratory Nonstationary Dynamics. IEEE Trans Biomed Eng vol. 65, (5) 1077-1085.

Porter B, van Duijvenboden S, Bishop MJ, Orini M, Claridge S, Gould J, Sieniewicz BJ, Sidhu B et al.(2018). Beat-to-Beat Variability of Ventricular Action Potential Duration Oscillates at Low Frequency During Sympathetic Provocation in Humans. Front Physiol vol. 9,

Orini M, Tinker A, Munroe PB, Lambiase PD(2018). Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. PLoS One vol. 13, (2)

Bolea J, Pueyo E, Orini M, Bailón R(2018). Corrigendum: Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing. Front Physiol vol. 9,

Orini M, Nanda A, Yates M, Di Salvo C, Roberts N, Lambiase PD, Taggart P(2017). Mechano-electrical feedback in the clinical setting: Current perspectives. Prog Biophys Mol Biol vol. 130, (Pt B) 365-375.

Andrews CM, Srinivasan NT, Rosmini S, Bulluck H, Orini M, Jenkins S, Pantazis A, McKenna WJ et al.(2017). Response by Andrews et al to Letter Regarding Article, "Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging". Circ Arrhythm Electrophysiol vol. 10, (10)

Orini M, Tinker A, Munroe PB, Lambiase PD(2017). Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. PLoS One vol. 12, (9) e0183732-e0183732.

Orini M, Barbieri R, Nardelli M, Scilingo EP, Valenza G(2017). Introduction to complex cardiovascular physiology.

Orini M, Laguna P, Mainardi LT, Bailón R(2017). Time-frequency analysis of cardiovascular signals and their dynamic interactions. Complexity and Nonlinearity in Cardiovascular Signals,

Graham AJ, Orini M, Lambiase PD(2017). Limitations and Challenges in Mapping Ventricular Tachycardia: New Technologies and Future Directions. Arrhythm Electrophysiol Rev vol. 6, (3) 118-124.

Andrews CM, Srinivasan NT, Rosmini S, Bulluck H, Orini M, Jenkins S, Pantazis A, McKenna WJ et al.(2017). Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging. Circ Arrhythm Electrophysiol vol. 10, (7)

Ramirez J, Orini M, Tucker JD, Pueyo E, Laguna P(2017). Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-Waves. IEEE Trans Biomed Eng vol. 64, (7) 1619-1630.

Martin C, Orini M, Srinivasan N, Bhar-Amato J, Chow A, Lowe M, Simon R, Taggart P et al. (2017). GLOBAL HIGH DENSITY MAPPING OF RE-ENTRY VULNERABILITY INDEX AIDS RISK STRATIFICATION AND IDENTIFIES SITES OF ARRHYTHMIA INITIATION IN BRUGADA SYNDROME AND ARVC. HEART. vol. 103, A25-A26.

Ramírez J, Orini M, Mincholé A, Monasterio V, Cygankiewicz I, Bayés de Luna A, Martínez JP, Pueyo E et al.(2017). T-Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure. J Am Heart Assoc vol. 6, (5)

Orini M, Taggart P, Hayward M, Lambiase PD(2017). Spatiotemporal characterization of the transition from sinus rhythm to ventricular fibrillation during an acute ischemic event in the intact human heart by whole-heart sock-mapping. HeartRhythm Case Rep vol. 3, (5) 259-263.

Ramírez J, Orini M, Pueyo E, Laguna P (2017). Comparison of ECG T-wave Duration and morphology restitution markers for sudden cardiac death prediction in chronic heart Failure. Computing in Cardiology. vol. 44, 1-4.

Orini M, Taggart P, Hayward M, Lambiase PD (2017). Optimization of the global re-entry vulnerability index to minimise cycle length dependency and prediction of ventricular arrhythmias during human epicardial sock mapping. Computing in Cardiology. vol. 44, 1-4.

Van Duijvenboden S, Child N, Gill JS, Hanson B, Taggart P, Orini M (2017). Pulse arrival time accurately detects pacing-induced mechanical alternans. Computing in Cardiology. vol. 44, 1-4.

Ramírez J, Orini M, Pueyo E, Laguna P (2017). Quantification of t-wave morphological variability using time-warping methods. IFMBE Proceedings. vol. 65, 478-481.

Ramírez J, Orini M, Mincholé A, Monasterio V, Cygankiewicz I, Bayés de Luna A, Martínez JP, Laguna P et al.(2017). Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model. PLoS One vol. 12, (10)

Ramírez J, Orini M, Pueyo E, Laguna P (2017). T-wave morphology restitution dependency with heart rate range and its association with sudden cardiac death in chronic heart failure. Computing in Cardiology. vol. 44, 1-4.

Cerruto G, Mainardi L, Koelsch S, Orini M (2017). The periodic repolarization dynamics index identifies changes in ventricular repolarization oscillations associated with music-induced emotions. Computing in Cardiology. vol. 44, 1-4.

Orini M, Van Duijvenboden S, Srinivasan N, Finlay M, Taggart P, Lambiase PD (2017). Theoretical assessment of a repolarization time marker based on the intracardiac bipolar electrogram. Computing in Cardiology. vol. 44, 1-4.

Srinivasan NT, Orini M, Simon RB, Providência R, Khan FZ, Segal OR, Babu GG, Bradley R et al.(2016). Ventricular stimulus site influences dynamic dispersion of repolarization in the intact human heart. Am J Physiol Heart Circ Physiol vol. 311, (3) H545-H554.

Orini M, Taggart P, Lambiase PD(2016). A multivariate time-frequency approach for tracking QT variability changes unrelated to heart rate variability. Conf Proc IEEE Eng Med Biol Soc vol. 2016, 924-927.

Santos D, Orini M, Zhou X, Bueno-Orovio A, Hanson B, Taggart P, Hayward M, Rodriguez B et al.(2016). Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart. Conf Proc IEEE Eng Med Biol Soc vol. 2016, 157-160.

Pueyo E, Orini M, Rodríguez JF, Taggart P(2016). Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans. J Mol Cell Cardiol vol. 97, 93-105.

Noriega M, Maranon EJ, Romero D, Orini M, Almeida R(2016). Respiratory rate estimation from multilead directions, based on ECG delineation. Conf Proc IEEE Eng Med Biol Soc vol. 2016, 3813-3816.

Ramirez J, Orini M, Derek Tucker J, Pueyo E, Laguna P (2016). An index for T-wave pointwise amplitude variability quantification. Computing in Cardiology. vol. 43, 49-52.

Zhou X, Bueno-Orovio A, Orini M, Hanson B, Hayward M, Taggart P, Lambiase PD, Burrage K et al.(2016). In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes. Circ Res vol. 118, (2) 266-278.

Bolea J, Pueyo E, Orini M, Bailón R(2016). Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing. Front Physiol vol. 7,

Orini M, Taggart P, Srinivasan N, Hayward M, Lambiase PD(2016). Interactions between Activation and Repolarization Restitution Properties in the Intact Human Heart: In-Vivo Whole-Heart Data and Mathematical Description. PLoS One vol. 11, (9)

van Duijvenboden S, Hanson B, Child N, Orini M, Rinaldi CA, Gill JS, Taggart P(2015). Effect of autonomic blocking agents on the respiratory-related oscillations of ventricular action potential duration in humans. Am J Physiol Heart Circ Physiol vol. 309, (12) H2108-H2117.

Orini M, Taggart P, Hayward M, Lambiase PD(2015). Analytical description of the slope of the APD-restitution curve to assess the interacting contribution of conduction and repolarization dynamics. Conf Proc IEEE Eng Med Biol Soc vol. 2015, 5672-5675.

Lambiase PD, Yanni J, Orini M, Hanson B, Hayward M, Smith A, Zhang H, Dobrzynski H et al. (2015). Molecular profiling of repolarization alternans recorded in the in-vivo human heart demonstrates changes in Ca2+handling proteins and repolarizing currents. EUROPEAN HEART JOURNAL. vol. 36, 31-32.

Orini M, Taggart P, Hayward M, Lambiase P(2015). On how 2∶1 conduction block can induce T-wave alternans in the unipolar intracavitary electrogram: Modelling in-vivo human recordings from an ischemic heart. Conf Proc IEEE Eng Med Biol Soc vol. 2015, 5676-5679.

Van Duijvenboden S, Orini M, Child N, Gill JS, Taggart P, Hanson B (2015). Investigation of causal interactions between ventricular action potential duration, blood pressure and respiration. Computing in Cardiology. vol. 42, 621-624.

Orini M, Srinivasan N, Taggart P, Lambiase P (2015). Reliability of APD-restitution slope measurements: Quantification and methodological comparison. Computing in Cardiology. vol. 42, 545-548.

Orini M, Blasi C, Finlay M, Hanson B, Lambiase P, Sassi R, Mainardi LT (2015). Validation of the V-index as a metric of ventricular repolarization dispersion using intracardiac recordings. Computing in Cardiology. vol. 42, 673-676.

van Duijvenboden S, Orini M, Taggart P, Hanson B(2015). Accuracy of measurements derived from intracardiac unipolar electrograms: A simulation study. Conf Proc IEEE Eng Med Biol Soc vol. 2015, 76-79.

Valenza G, Faes L, Citi L, Orini M, Barbieri R(2015). Instantaneous transfer entropy for the study of cardio-respiratory dynamics. Conf Proc IEEE Eng Med Biol Soc vol. 2015, 7885-7888.

Taggart P, Orini M, Hanson B, Hayward M, Clayton R, Dobrzynski H, Yanni J, Boyett M et al.(2014). Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects. Prog Biophys Mol Biol vol. 115, (2-3) 252-260.

Orini M, Hanson B, Monasterio V, Martínez JP, Hayward M, Taggart P, Lambiase P(2014). Comparative evaluation of methodologies for T-wave alternans mapping in electrograms. IEEE Trans Biomed Eng vol. 61, (2) 308-316.

Valenza G, Orini M, Citi L, Minchole A, Pueyo E, Laguna P, Barbieri R (2014). Assessing instantaneous QT variability dynamics within a point-process nonlinear framework. 2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014. 67-68.

Valenza G, Orini M, Citi L, Minchole A, Pueyo E, Laguna P, Barbieri R(2014). Assessing real-time RR-QT frequency-domain measures of coupling and causality through inhomogeneous point-process bivariate models. Conf Proc IEEE Eng Med Biol Soc vol. 2014, 6475-6478.

Hanson B, Child N, Van Duijvenboden S, Orini M, Chen Z, Coronel R, Rinaldi CA, Gill JS et al.(2014). Oscillatory behavior of ventricular action potential duration in heart failure patients at respiratory rate and low frequency. Front Physiol vol. 5,

Widjaja D, Orini M, Vlemincx E, Van Huffel S (2013). Analysis of cardio-respiratory dynamics during mental stress using (partial) time-frequency spectra. Computing in Cardiology. vol. 40, 105-108.

Orini M, Citi L, Hanson BM, Taggart P, Lambiase PD (2013). Characterization of the causal interactions between depolarization and repolarization temporal changes in unipolar electrograms. Computing in Cardiology. vol. 40, 719-722.

Hernando D, Alcaine A, Pueyo E, Laguna P, Orini M, Arcentales A, Giraldo B, Voss A et al. (2013). Influence of respiration in the very low frequency modulation of QRS slopes and heart rate variability in cardiomyopathy patients. Computing in Cardiology. vol. 40, 117-120.

Zhou X, Bueno-Orovio A, Orini M, Hanson B, Hayward M, Taggart P, Lambiase PD, Burrage K et al. (2013). Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans. Computing in Cardiology. vol. 40, 855-858.

Widjaja D, Orini M, Vlemincx E, Van Huffel S(2013). Cardiorespiratory dynamic response to mental stress: a multivariate time-frequency analysis. Comput Math Methods Med vol. 2013,

Peláez-Coca MD, Orini M, Lázaro J, Bailón R, Gil E(2013). Cross time-frequency analysis for combining information of several sources: application to estimation of spontaneous respiratory rate from photoplethysmography. Comput Math Methods Med vol. 2013,

Orini M, Hanson B, Taggart P, Lambiase P(2013). Detection of transient, regional cardiac repolarization alternans by time-frequency analysis of synthetic electrograms. Conf Proc IEEE Eng Med Biol Soc vol. 2013, 3773-3776.

Orini M, Bailón R, Laguna P, Mainardi LT, Barbieri R(2012). A multivariate time-frequency method to characterize the influence of respiration over heart period and arterial pressure Advances in Nonstationary Electrophysiological Signal Analysis and Processing. Eurasip Journal on Advances in Signal Processing vol. 2012, (1)

Orini M, Valenza G, Citi L, Barbieri R (2012). Tetravariate point-process model for the continuous characterization of cardiovascular-respiratory dynamics during passive postural changes. Computing in Cardiology. vol. 39, 273-276.

Orini M, Laguna P, Mainardi LT, Bailón R(2012). Assessment of the dynamic interactions between heart rate and arterial pressure by the cross time-frequency analysis. Physiol Meas vol. 33, (3) 315-331.

Orini M, Bailón R, Mainardi LT, Laguna P, Flandrin P(2012). Characterization of dynamic interactions between cardiovascular signals by time-frequency coherence. IEEE Trans Biomed Eng vol. 59, (3) 663-673.

Orini M, Bailón R, Mainardi L, Laguna P(2012). Synthesis of HRV signals characterized by predetermined time-frequency structure by means of time-varying ARMA models. Biomedical Signal Processing and Control vol. 7, (2) 141-150.

Orini M, Citi L, Barbieri R(2012). Bivariate point process modeling and joint non-stationary analysis of pulse transit time and heart period. Conf Proc IEEE Eng Med Biol Soc vol. 2012, 2831-2834.

Orini M, Peláez-Coca MD, Bailón R, Gil E (2011). Estimation of spontaneous respiratory rate from photoplethysmography by cross time-frequency analysis. Computing in Cardiology. vol. 38, 661-664.

Bailón R, Laouini G, Grao C, Orini M, Laguna P, Meste O(2011). The integral pulse frequency modulation model with time-varying threshold: application to heart rate variability analysis during exercise stress testing. IEEE Trans Biomed Eng vol. 58, (3) 642-652.

Orini M, Bailón R, Mainardi LT, Laguna P(2011). Time-frequency phase differences and phase locking to characterize dynamic interactions between cardiovascular signals. Conf Proc IEEE Eng Med Biol Soc vol. 2011, 4689-4692.

Cirugeda E, Orini M, Laguna P, Bailón R (2010). Respiratory frequency estimation from heart rate variability signals in non-stationary Conditions based on the Wigner-Ville distribution. Computing in Cardiology. vol. 37, 717-720.

Bailón R, Mainardi L, Orini M, Sörnmo L, Laguna P(2010). Analysis of heart rate variability during exercise stress testing using respiratory information. Biomedical Signal Processing and Control vol. 5, (4) 299-310.

Gil E, Orini M, Bailón R, Vergara JM, Mainardi L, Laguna P(2010). Photoplethysmography pulse rate variability as a surrogate measurement of heart rate variability during non-stationary conditions. Physiol Meas vol. 31, (9) 1271-1290.

Orini M, Bailón R, Enk R, Koelsch S, Mainardi L, Laguna P(2010). A method for continuously assessing the autonomic response to music-induced emotions through HRV analysis. Med Biol Eng Comput vol. 48, (5) 423-433.

Orini M, Mainardi LT, Gil E, Laguna P, Bailon R(2010). Dynamic assessment of spontaneous baroreflex sensitivity by means of time-frequency analysis using either RR or pulse interval variability. Conf Proc IEEE Eng Med Biol Soc vol. 2010, 1630-1633.

Gil E, Orini M, Bailon R, Vergara JM, Mainardi L, Laguna P(2010). Time-varying spectral analysis for comparison of HRV and PPG variability during tilt table test. Conf Proc IEEE Eng Med Biol Soc vol. 2010, 3579-3582.

Orini M, Bailón R, Mainardi LT, Mincholé A, Laguna P (2009). Continuous quantification of spectral coherence using quadratic time-frequency distributions: Error analysis and application. Computers in Cardiology. vol. 36, 681-684.

Orini M, Giraldo BF, Bailón R, Vallverdu M, Mainardi L, Benito S, Díaz I, Caminal P(2008). Time-frequency analysis of cardiac and respiratory parameters for the prediction of ventilator weaning. Conf Proc IEEE Eng Med Biol Soc vol. 2008, 2793-2796.

Orini M, Bailón R, Laguna P, Mainardi LT (2007). Modeling and estimation of time-varying heart rate variability during stress test by parametric and non parametric analysis. Computers in Cardiology. vol. 34, 29-32.