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Publications:  Dr Christopher Harry Switzer

Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P(2020). Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth. Redox Biology vol. 29,
10.1016/j.redox.2019.101405
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.(2019). Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase". Circulation vol. 140, (22) E810-E811.
10.1161/CIRCULATIONAHA.119.043869
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P et al.(2019). Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase. Circulation vol. 140, (2) 126-137.
10.1161/CIRCULATIONAHA.118.037398
Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P(2018). Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. Molecular Cell vol. 69, (3) 438-450.e5.
10.1016/j.molcel.2017.12.019
https://qmro.qmul.ac.uk/xmlui/handle/123456789/65636
Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD et al.(2015). Signaling and stress: The redox landscape in NOS2 biology. Free Radical Biology and Medicine vol. 87, 204-225.
10.1016/j.freeradbiomed.2015.06.002
Cheng RYS, Basudhar D, Ridnour LA, Heinecke JL, Kesarwala AH, Glynn S, Switzer CH, Ambs S et al.(2014). Gene expression profiles of NO- and HNO-donor treated breast cancer cells: Insights into tumor response and resistance pathways. Nitric Oxide - Biology and Chemistry vol. 43, 17-28.
10.1016/j.niox.2014.08.003
Heinecke JL, Ridnour LA, Cheng RYS, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP et al.(2014). Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America vol. 111, (17) 6323-6328.
10.1073/pnas.1401799111
Heinrich TA, Da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM(2013). Biological nitric oxide signalling: Chemistry and terminology. British Journal of Pharmacology vol. 169, (7) 1417-1429.
10.1111/bph.12217
Ridnour LA, Cheng RYS, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G et al.(2013). Molecular pathways: Toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity. Clinical Cancer Research vol. 19, (6) 1340-1346.
10.1158/1078-0432.CCR-12-0408
Switzer CH, Miller TW, Farmer PJ, Fukuto JM(2013). Synthesis and characterization of lithium oxonitrate (LiNO). Journal of Inorganic Biochemistry vol. 118, 128-133.
10.1016/j.jinorgbio.2012.09.022
Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA (2012). S-nitrosation mediates multiple pathways, that lead to tumor progression in estrogen receptor - Negative breast cancer. Forum on Immunopathological Diseases and Therapeutics. vol. 3, 117-124.
10.1615/ForumImmunDisTher.2012006108
Switzer CH, Cheng RYS, Ridnour LA, Glynn SA, Ambs S, Wink DA(2012). Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer. Breast Cancer Research vol. 14, (5)
10.1186/bcr3319
Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH et al.(2012). Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation. PLoS ONE vol. 7, (9)
10.1371/journal.pone.0044081
Switzer CH, Glynn SA, Cheng RYS, Ridnour LA, Green JE, Ambs S, Wink DA(2012). S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer. Molecular Cancer Research vol. 10, (9) 1203-1215.
10.1158/1541-7786.MCR-12-0124
Switzer CH, Cheng RYS, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB et al.(2012). Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer. Cancer Research vol. 72, (9) 2394-2404.
10.1158/0008-5472.CAN-11-3115
Switzer CH, Glynn SA, Ridnour LA, Cheng RYS, Vitek MP, Ambs S, Wink DA(2011). Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. Trends in Pharmacological Sciences vol. 32, (11) 644-651.
10.1016/j.tips.2011.07.001
Switzer CH, Cheng RYS, Vitek TM, Christensen DJ, Wink DA, Vitek MP(2011). Targeting SET/I<inf>2</inf> PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. Oncogene vol. 30, (22) 2504-2513.
10.1038/onc.2010.622
Wink DA, Hines HB, Cheng RYS, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA(2011). Nitric oxide and redox mechanisms in the immune response. Journal of Leukocyte Biology vol. 89, (6) 873-891.
10.1189/jlb.1010550
Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA et al.(2011). The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxidants and Redox Signaling vol. 14, (9) 1659-1674.
10.1089/ars.2010.3841
Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH et al.(2010). Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. Journal of Clinical Investigation vol. 120, (11) 3843-3854.
10.1172/JCI42059
Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A et al.(2010). Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. Lung Cancer vol. 68, (2) 154-160.
10.1016/j.lungcan.2009.06.012
Thomas DD, Flores-Santana W, Switzer CH, Wink DA, Ridnour LA(2010). Determinants of Nitric Oxide Chemistry. Impact of Cell Signaling Processes. Nitric Oxide,
Cheng R, Glynn S, Flores-Santana W, Switzer C, Ridnour L, Wink DA(2010). Nitric oxide and redox inflammation in cancer. Advances in Molecular Toxicology vol. 4, (C) 157-182.
10.1016/S1872-0854(10)04005-1
Switzer CH, Ridnour LA, Cheng RYS, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD et al.(2009). Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity. Oncogene vol. 28, (43) 3837-3846.
10.1038/onc.2009.244
Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM et al.(2009). Comparing the chemical biology of NO and HNO. Archives of Pharmacal Research vol. 32, (8) 1139-1153.
10.1007/s12272-009-1805-x
Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM et al.(2009). The emergence of nitroxyl (HNO) as a pharmacological agent. Biochimica et Biophysica Acta - Bioenergetics vol. 1787, (7) 835-840.
10.1016/j.bbabio.2009.04.015
Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang J, Stuehr DJ, King SB et al.(2008). Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Radical Biology and Medicine vol. 45, (5) 578-584.
10.1016/j.freeradbiomed.2008.04.036
Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA(2008). Molecular mechanisms for discrete nitric oxide levels in cancer. Nitric Oxide - Biology and Chemistry vol. 19, (2) 73-76.
10.1016/j.niox.2008.04.006
Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C et al.(2008). The chemical biology of nitric oxide: Implications in cellular signaling. Free Radical Biology and Medicine vol. 45, (1) 18-31.
10.1016/j.freeradbiomed.2008.03.020
Isenberg JS, Jia Y, Fukuyama J, Switzer CH, Wink DA, Roberts DD(2007). Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. Journal of Biological Chemistry vol. 282, (21) 15404-15415.
10.1074/jbc.M701638200
Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB et al.(2006). The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: A new feature of nitrogen oxide signaling. Antioxidants and Redox Signaling vol. 8, (7-8) 1363-1371.
10.1089/ars.2006.8.1363
Fukuto JM, Switzer CH, Miranda KM, Wink DA(2005). Nitroxyl (HNO): Chemistry, biochemistry, and pharmacology.
Bartberger MD, Liu W, Ford E, Miranda KM, Switzer C, Fukuto JM, Farmer PJ, Wink DA et al.(2002). The reduction potential of nitric oxide (NO) and its importance to NO biochemistry. Proceedings of the National Academy of Sciences of the United States of America vol. 99, (17) 10958-10963.
10.1073/pnas.162095599
Shinyashiki M, Pan CJG, Switzer CH, Fukuto JM(2001). Mechanisms of nitrogen oxide-mediated disruption of metalloprotein function: An examination of the copper-responsive yeast transcription factor ace1. Chemical Research in Toxicology vol. 14, (12) 1584-1589.
10.1021/tx010102i
Chiang KT, Switzer CH, Akali KO, Fukuto JM(2000). The role of oxygen and reduced oxygen species in nitric oxide-mediated cytotoxicity: Studies in the yeast Saccharomyces cerevisiae model system. Toxicology and Applied Pharmacology vol. 167, (1) 30-36.
10.1006/taap.2000.8970
Chiang KT, Shinyashiki M, Switzer CH, Valentine JS, Gralla EB, Thiele DJ, Fukuto JM(2000). Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: Cytotoxic and cytoprotective actions of nitric oxide. Archives of Biochemistry and Biophysics vol. 377, (2) 296-303.
10.1006/abbi.2000.1785
Shinyashiki M, Chiang KT, Switzer CH, Gralla EB, Valentine JS, Thiele DJ, Fukuto JM(2000). The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism. Proceedings of the National Academy of Sciences of the United States of America vol. 97, (6) 2491-2496.
10.1073/pnas.050586597
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